Leiden Muscular Dystrophy pages©

Sequences / markers in and around the dystrophin gene

(last modified April 6, 2006)


Introduction

This page lists the order of markers in and around the DMD gene. The markers are provided in relation to the DMD gene's transcriptional orientation, i.e. from centromere to telomere. In addition, links are provided to the sequences as present in GenBank (NCBI). On specific issues, more detailed data can be found at;


Tabular listing

Exon DXS nr. Probe name GenBank Map position Reference
DXS1258
DXS1268
DXS84 754
Dp427l promoter / exon 1 D32048
SfiI-A
5'DYS-III AF209165 11.8 kb 5' Dp427b exon 1 Feener (1991)
5'DYS-I AF209163 3.5 kb 5' Dp427b exon 1 Feener (1991)
DXS1242 5'DYS-II / sWXD2450 AF209164 1.2 kb 5' Dp427b exon 1 Feener (1991)
Dp427c promoter/exon 1 L01538, M59228, X15148 Kunkel, Boyce
intron 1b
5'DYS-IV AF209166 4.3 kb 3' Dp427b exon 1 Feener (1991)
SfiI-B 89 kb 5' of Dp427m exon 1
(c.-8043(AC)16_30) 5'DYS MSB / sWXD2452 8 kb 5' of Dp427m exon 1 Oudet (1991)
Dp427m promoter/exon 1 AF213401 (primer 1F/1R X65341 / X65342), AF054599 (L1-insert), M32058 40 kb 3' Dp427b + 97 kb 5' Dp427m Beggs, Abbs
intron 1 DXS142 pERT84-1 L37425 13 kb 3' of Dp427m exon 1 Roberts, Koenig
DXS1243
(c.31+15515(AC)8_24)
5'-5n1 / 5'DYS MSA X75920 15.4 kb 3' Dp427m exon 1 King (1995), Oudet (1991)
Dp427p promoter/exon 1 S81419, S64152 82 kb 3' of Dp427m exon 1 Gorecki
intron 1 5'-5n3 X75801 (NOTE: not contiguous sequence - 3' segment maps downstream) 36 kb 3' exon 2
(5' part in intron 1)
King (1994), King (1995)
exon 'X' L06900 50 kb 3' of Dp427p exon 1 Roberts
exon 2 AF213402 (Leiden unp.)
intron 2 5'-5n3 X75801 (NOTE: not contiguous sequence - 5' segment maps upstream) King (1994), King (1995)
DXS272 J47 Smith
exon 3 AF213403 (primer 3F/3R X65343 / X65344) Beggs, Abbs
intron 3
exon 4 AF213404 Chamberlain, Abbs
intron 4 5'-5n4 X77678 8.4 kb 5' exon 5 King (1995)
exon 5 AF213405 (Leiden unp.)
intron 5 HH1
exon 6 AF213406, (primer 6F/6R X65345 / X65346) Beggs, Abbs
intron 6
exon 7 AF213407 (Leiden unp.)
intron 7

(detailed description)
t(X;21) intron 7 A05312, L08092, M18024 McNaughton
DMDSTR07A 22 kb 3' exon 7 DB: Leiden
DMDSTR07B 23 kb 3' exon 7 DB: Leiden
XJ5.1 30 kb 3' of exon 7 McNaughton
DXS230 XJ1.2 / HIP25 45 kb 3' of exon 7 McNaughton
DXS206 XJ1.1 55 kb 3' of exon 7 McNaughton
XJ2.3 60 kb 3' of exon 7 McNaughton
XJ8.1 100 kb 3' of exon 7
XJ10.2 110 kb 3' of exon 7
DXS164
(in GDB)
pERT87-42 23 kb 5' exon 8 Monaco, Smith
pERT87-37 20 kb 5' exon 8 Monaco
pERT87-32 17 kb 5' exon 8 Monaco
exon 8 AF213408, M23261, X06293, Y00494 Chamberlain, Abbs
intron 8   McNaughton
exon 9 AF213409
intron 9
exon 10 AF213410
intron 10
exon 11 AF213411
intron 11
DXS164
(in GDB)
pERT87-28 Y13187 14 kb 3' exon 11 Monaco
SfiI-C 20 kb 3' exon 11 (Leiden unp.)
pERT87-23 21 kb 3' exon 11 Monaco
exon 12 AF213412, I07692 Chamberlain
intron 12 DXS164
(in GDB)
pERT87-12 14 kb 3' exon 12 Monaco
exon 13 AF213413, X64610 / X64612 (JBir-junction), (primer 13F/13R X65347 / X65348) Beggs, Abbs
intron 13 DXS164
(in GDB)
pERT87-1 5 kb 3' exon 13 Monaco
pERT87-16 6 kb 3' exon 13 Monaco
pERT87-14 18 kb 3' exon 13 Monaco
pERT87-8 L05531 19 kb 3' exon 13 Roberts, Monaco
exon 14 AF213414
intron 14
exon 15 AF213414
intron 15 DXS164
(in GDB)
pERT87-4 M36671 1 kb 3' exon 15 Monaco
exon 16 AF213415 Kunkel
intron 16 S90704, S90696, X64608, X64611
exon 17 AF213416, L05532, X13045, X63691 Chamberlain
intron 17
DXS164
(in GDB)
pERT87-15 L05532, X13045, X63691 1 kb 3' exon 17 Roberts, Monaco
pERT87-13 8 kb 3' exon 17 Monaco
pERT87-22 10 kb 5' exon 18 Monaco
exon 18 AF213417 (Leiden unp.)
intron 18 DXS164
(in GDB)
pERT87-27 10 kb 3' exon 18 Monaco
exon 19 DXS164
(in GDB)
pERT87-25 M36673, M55699 Chamberlain, Abbs
intron 19 DXS164
(in GDB)
pERT87-25 3 kb 3' exon 19 Monaco
exon 20 AF213418 (Leiden unp.)
intron 20 DXS164
(in GDB)
pERT87-30 7 kb 3' exon 20 Monaco
pERT87-41 AL031542 20 kb 3' exon 20 Monaco
exon 21 AF213419 (Leiden unp.)
intron 21
exon 22 AF213420 (Leiden unp.)
intron 22
exon 23 L05636, L11637 (Leiden unp.)
intron 23
exon 24 L05637, L11638
intron 24
exon 25 L05638, L11639
intron 25   5'-7n4 X77677 1.5 kb 5' exon 26 King (1995)
intron 25-40 DXS271 SK1 (Leiden unp.)
exon 26        L05639, S43366, S71486 (Leiden unp.)
intron 26
exon 27 AF213421AB006975, L05650
intron 27 AL031542
exon 28 L05640
intron 28
exon 29 L05641 (Leiden unp.)
intron 29 SfiI-D 5 kb 3' exon 29
Dp260 promoter/exon 1 L05642, U27203 directly 5'  exon 30
exon 30 L05642
intron 30
exon 31 AF213422
intron 31
exon 32 AF213423, L41643
intron 32
exon 33 AF213424
intron 33
exon 34 L05643
intron 34
exon 35 AF213425
intron 35          
exon 36 AF213426, X64608
intron 36
exon 37 AF213427
intron 37
exon 38 L05644
intron 38
exon 39 L05645
intron 39
exon 40 AF213428, L05646 (Leiden unp.)
intron 40
exon 41 AF213429 Kunkel
intron 41 SfiI-E 5 kb 5' of exon 42
exon 42 AF213430 Kunkel
intron 42 SfiI-E' (Leiden unp.)
exon 43 AF213431, L41634, (primer 43F/43R X65349 / X65350) Beggs, Abbs
intron 43 DXS270 JBir X64612 (JBir junction), X64609, X64611, M87299, AF213432 just 3' of exon 43 Koenig
exon 44 JdD44, S61546, U94396, X13046 Chamberlain
intron 44 DXS1238 STR-44 AF209157, M81257 13.8 kb 3' exon 44 Clemens (1991)
IVS44SK12 50 kb 3' exon 44 Kochling (1995)
IVS44SK21 X77644 50 kb 3' exon 44 Kochling (1995)
Dp140 promoter/exon 1 Dp140 promoter/exon 1 (IVS44SK12, IVS44SK21), U90310, L35854 50 kb 3' exon 44 Lidov
intron 44 DXS1219 AFM297yd1 Z24187 Dib (1996)
M65036, M65035
DXS269
(in GDB)
M86524 (P20-CA) 5-10 kb 5' of P20b (den Dunnen, unpl.)
P20a 40-45 kb 5' of exon 45 (den Dunnen, unpl.)
P20 (deletion junction
of P20a / P20b)
AF209182 (den Dunnen, unpl.)
Z11838 / Z22650 (P20-Alu RFLP / Alu insert) directly upstream of P20b (in 3'-5' orientation) Blonden
P20b AF209189 ~8 kb 5' of exon 45 (den Dunnen, unpl.)
exon 45 X13048, X15495 Chamberlain
intron 45 DXS1237
(in GDB)
STR-45.1 AF209158 1.2 kb 3' exon 45 Clemens
STR-45.2 AF209159 .. kb 3' exon 45 (Chamberlain, unpl.)
exon 46 I07712 Beggs
intron 46
exon 47 AF213433, L41635, (primer 47F/47R X65351 / X65352) Beggs, Abbs
intron 47
exon 48 X13047, X54820, L41635 Chamberlain, Abbs
intron 48 SfiI-F 2.8 kb 3' exon 48
DXS997
(in GDB)
AFM217xa5 Z16983 , M65036 3.6 kb 3' exon 48 Dib (1996)
STR-48 AF209160 29 kb 3' exon 48
exon 49 AF213434, (primer 49F/49R X65359 / X65360) Beggs
intron 49 DXS1236 STR-49 AF209161 intron 49 Clemens
exon 50 AF213435 (primer 50F/50R X65353 / X65354) Beggs, Abbs
intron 50 DXS1235

DXS1067
STR-50 AF209162, Z23710 5.5 kb 5' exon 51 Clemens, Dib (1996)
AFM234vg7
DXS239 GMGX11
exon 51 AF213436, X51934, M65035, X16089
intron 51 DXS1036
(in GDB)
AFM072h3 Z23325, M62511 Dib (1996)
exon 52 AF213437, (primer 52F/52R X65355 / X65356)
intron 52
exon 53   AF213438
intron 53
exon 54 AF213439
intron 54 SfiI-G
exon 55 AF213440, L37431 Nobile, (Leiden unp.)
intron 55
Dp116 promoter/exon 1 S62618
exon 56 L05647
intron 56
exon 57 L04186
intron 57
exon 58 L05648
intron 58
exon 59 L05649
intron 59 DXS1241 DMD1-2c X55151 Powell, (den Dunnen, unpl.)
exon 60 Z11860, M86884, (primer 60F/60R X65357 / X65358)
intron 60 DXS268 J66 VNTR Z11861 just 3' of exon 66 van Ommen
SfiI-H, SfiI-I
exon 61 M86885
intron 61 SfiI-I'
exon 62 M86886
intron 62
Dp71/40 promoter/exon 1 S42212 8 kb 5' exon 63
exon 63 M86887
intron 63 STR62/63 Taylor et al. (unpublished)
DXS1214
(in GDB)
AFM283wg9 Z24023 Dib (1996)
M62510, M62512, M62513
exon 64 AF213441, M86888
intron 64 STRHI (Cockburn, unpl.)
exon 65 M86889
intron 65            
exon 66 M86890
intron 66
exon 67 M86891
intron 67
exon 68 M86892
intron 68
exon 69 M86893
intron 69
exon 70 AF213442, M86894, X15149
intron 70 
exon 71 M86895
intron 71
exon 72 M86896
intron 72  
exon 73   M86897
intron 73  
exon 74 M86898
intron 74
exon 75 AF213443, M86899
intron 75
exon 76 M86900
intron 76
exon 77 M86901
intron 77
exon 78 M86902
intron 78 AF213444
exon 79 M86903, M86904, M18533
DXS1234 3'DYS MSC exon 79 (11,550) Oudet (1990), Beggs (1990)
MP1S exon 79 (12,000) Roberts (1989)
DXS503 MP1P exon 79 (12,100) Abbs (1990), Roberts (1989)
MP1Q exon 79 (12,620) Abbs (1990), Roberts (1989)
DXS726 FT-1 9.5 kb 3' exon 79 Worley (1992)
3'-19n8 X75580 200 kb 3' 
of exon 79
King (1994), King (1995)
DXS992 AFM184xg5 Z16803 > 200 kb 3' 
of exon 79
(den Dunnen, unp.)
DXS985 AFM112xf2 Z16589 >200 kb 3' 
of exon 79
Dib (1996)
GKD
DXS1065, DXS1202
DXS1028, DXS1061
AHC
DXS319 QST59 Worley
DXS727 YHX39R Worley
DXS28 C7
DXS67 B24
DXS68 L1-4
DXS41 99.6
DXS43 D2

Legend:
Exon: dystrophin gene (DMD) exon / intron number; links provided refer to a local copy of the respective segment of the "DMD gene Genomic Reference Sequence". DXS nr.: DXS number of probe, with link to UniSTS database at NCBIor the Genome DataBase (GDB). Probe name: lab or alternative name of the marker / probe. GenBank: accession number with link to the sequence(s) in GenBank; DMD:.... = link to a local copy of those GenBank sequences submitted by us (see GenBank submissions from the Leiden Muscular Dystrophy pages). When more than one accession number is given, the sequences overlap. Map position: location of the sequence in relation to the DMD gene Genomic Reference Sequence. Reference: publication describing the marker / probe. No reference usually means "Leiden, unpublished" (Leiden unp.).



| Top of page |
| LMDp homepage | Remarks / information | Copyright©, liability |