Leiden Muscular Dystrophy pages^©

Sarcoglycan homologies

(last modified on November 30, 2002)

Contents

• SGCA / SGCE
• SGCB / SGCG / SGCD / SGCE
• alignments

SGCA / SGCE

• fruit fly [Drosophila melanogaster] - DmSCG-alpha/epsilon AF277391, protein AAG17400
• Caenorhabditis elegans - protein AAC64620 / genomic AF077544

SGCB / SGCG / SGCD / SGCZ

The human SGCD1 protein show a 95% amino acid identity with the hamster sequence, a weak homology with the N-terminus of beta-sarcoglycan and C. elegans clone F07H5.2. A weak homology was noted between the Cysteine-containing region of these sarcoglycans and the a so called "EGF-like cysteine containing repeat" of proteins like the LDL-receptor, laminin-A1 and fibrillin (McNally, consensus xCxCPxG[x]_5-15C).

Fruitfly (D. melanogaster) and C. elegans both contain one gene which shows a strong similarity equally related to SGCG, SGCD and SGCZ.

• similar sequences
  • fruit fly [Drosophila melanogaster] - DmSCG-beta AAG17401
  • Caenorhabditis elegans - gi:3875574
  • fruit fly [Drosophila melanogaster] - DmSCG-gamma/delta AAG17402
  • Caenorhabditis elegans - gi:3811364
  • fruit fly [Drosophila melanogaster] - DmSCG-beta AF277392

Legend: similarities of the human and mouse proteins with other sarcoglycan proteins (% identity / % similarity. For SGCD isoform-1 was taken. 

Alignment of sarcoglycan protein sequences

Not available yet

| Top of page | LMDp home page | dystrophin-associated glycoprotein complex |
| SGC-homepage | SGC-alpha, SGC-beta, SGC-gamma, SGC-delta, SGC-epsilon, SGC-zeta |
| Remarks / information | Disclaimer |