(last modified April 2, 2006)
Submitted to GenBank
LOCUS Dp427p 14000 bp mRNA PRI 02-APR-2006
DEFINITION Human dystrophin cDNA isoform Dp427p1 (Purkinje cells).
ACCESSION Dp427p
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 329)
AUTHORS Gorecki,D.C., Monaco,A.P., Derry,J.M., Walker,A.P., Barnard,E.A.
and Barnard,P.J.
TITLE Expression of four alternative dystrophin transcripts in brain
regions regulated by different promoters
JOURNAL Hum. Mol. Genet. 1 (7), 505-510 (1992)
MEDLINE 93338441
REFERENCE 2 (bases 2 to 294)
AUTHORS Holder,E., Maeda,M. and Bies,R.D.
TITLE Expression and regulation of the dystrophin Purkinje promoter in
human skeletal muscle, heart, and brain
JOURNAL Hum. Genet. 97 (2), 232-239 (1996)
MEDLINE 96163501
REFERENCE 3 (bases 1 to 14000)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
COMMENT Constructed consensus sequence of S64152, S81419 and M18533.
FEATURES Location/Qualifiers
source 1..14000
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp21.2"
5'UTR <1..263
misc_feature 264..284
/note="Region: dystrophin Dp427p unique N-terminus"
CDS 264..11309
/codon_start=1
/product="dystrophin Dp427p1"
/translation="MSEVSSDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGR
RLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKL
TLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWS
DGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTY
PDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITV
SLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESE
VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRV
GNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN
QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTH
MVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCL
FSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLL
STLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT
TVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS
PEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK
QASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTP
SEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF
KQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIME
QRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSS
QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR
LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKE
ALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQ
QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWA
CWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR
ILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI
QESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV
LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVV
QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELG
AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG
KATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLN
LLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPK
VDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNS
DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE
IKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP
EPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK
FAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA
PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEAL
SQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW
EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE
VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ
VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALP
EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET
EIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD
LAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD
WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS
NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQAR
AKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRK
VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQ
DATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL
LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA
PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE
LPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL
KLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLG
IQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERA
ISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLD
LLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLL
HDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLP
VLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHY
PMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTL
INFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHL
LIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLK
QQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQL
ESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEED
LLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"
misc_feature 285..971
/note="Region: Actin binding domain"
misc_feature 1008..9371
/note="Region: central rod domain"
misc_feature 1008..1232
/note="Region: hinge region 1"
misc_feature 1260..1592
/note="Region: repeat region 1"
misc_feature 1593..1919
/note="Region: repeat region 2"
misc_feature 1920..2252
/note="Region: repeat region 3"
misc_feature 2253..2402
/note="Region: hinge region 2"
misc_feature 2403..2735
/note="Region: repeat region 4"
misc_feature 2736..3053
/note="Region: repeat region 5"
misc_feature 3054..3386
/note="Region: repeat region 6"
misc_feature 3387..3713
/note="Region: repeat region 7"
misc_feature 3714..4040
/note="Region: repeat region 8"
misc_feature 4041..4352
/note="Region: repeat region 9"
misc_feature 4353..4640
/note="Region: repeat region 10"
misc_feature 4632..4955
/note="Region: repeat region 11"
misc_feature 4956..5279
/note="Region: repeat region 12"
misc_feature 5280..5585
/note="Region: repeat region 13"
misc_feature 5586..5873
/note="Region: repeat region 14"
misc_feature 5874..6170
/note="Region: repeat region 15"
misc_feature 6225..6554
/note="Region: repeat region 16"
misc_feature 6555..6875
/note="Region: repeat region 17"
misc_feature 6876..7205
/note="Region: repeat region 18"
misc_feature 7206..7520
/note="Region: repeat region 19"
misc_feature 7521..7661
/note="Region: hinge region 3"
misc_feature 7662..7982
/note="Region: repeat region 20"
misc_feature 7983..8309
/note="Region: repeat region 21"
misc_feature 8310..8657
/note="Region: repeat region 22"
misc_feature 8658..9044
/note="Region: repeat region 23"
misc_feature 9045..9371
/note="Region: repeat region 24"
misc_feature 9291..9587
/note="Region: hinge region 4"
misc_feature 9417..9527
/note="Region: WW-domain"
misc_feature 9489..10475
/note="dystroglycan binding site"
misc_feature 9549..10151
/note="Region: Cysteine-rich domain"
misc_feature 9639..9722
/note="Region: EF-hand 1"
misc_feature 9783..9869
/note="Region: EF-hand 2"
misc_feature 10149..11306
/note="Region: Carboxy-terminal region"
misc_feature 10170..10313
/note="Region: ZZ-domain"
misc_feature 10581..10733
/note="alpha1-syntrophin binding site"
misc_feature 10734..10856
/note="beta1-syntrophin binding site"
misc_feature 10734..10856
/note="Region: beta1-syntrophin binding site"
misc_feature 10923..11030
/note="Region: (Leu)6-heptad repeat"
3'UTR 11310..14000
polyA_signal 13978..13983
polyA_site 14000
BASE COUNT 4612 a 2798 c 3140 g 3450 t
ORIGIN
1 atgctgtctg tgaagctgaa tctgtgagaa cacctcacta ttcacggcaa ccggagtgga
61 agaaacaggt gcaaaaagat tgtgtgtttg tctgcttttg tgaggctggt cagagattct
121 gtgcctgctt tatctgtgct tggctatgac tctacctcca ggtttaccat accccataga
181 atgtgtaaga gaaaagtacc aacagggaaa tcagcaaaaa gctttcctat gaaggtgtgt
241 agccagcctc cgcagaattt gaaatgtctg aggtctcatc tgatgaaaga gaagatgttc
301 aaaagaaaac attcacaaaa tgggtaaatg cacaattttc taagtttggg aagcagcata
361 ttgagaacct cttcagtgac ctacaggatg ggaggcgcct cctagacctc ctcgaaggcc
421 tgacagggca aaaactgcca aaagaaaaag gatccacaag agttcatgcc ctgaacaatg
481 tcaacaaggc actgcgggtt ttgcagaaca ataatgttga tttagtgaat attggaagta
541 ctgacatcgt agatggaaat cataaactga ctcttggttt gatttggaat ataatcctcc
601 actggcaggt caaaaatgta atgaaaaata tcatggctgg attgcaacaa accaacagtg
661 aaaagattct cctgagctgg gtccgacaat caactcgtaa ttatccacag gttaatgtaa
721 tcaacttcac caccagctgg tctgatggcc tggctttgaa tgctctcatc catagtcata
781 ggccagacct atttgactgg aatagtgtgg tttgccagca gtcagccaca caacgactgg
841 aacatgcatt caacatcgcc agatatcaat taggcataga gaaactactc gatcctgaag
901 atgttgatac cacctatcca gataagaagt ccatcttaat gtacatcaca tcactcttcc
961 aagttttgcc tcaacaagtg agcattgaag ccatccagga agtggaaatg ttgccaaggc
1021 cacctaaagt gactaaagaa gaacattttc agttacatca tcaaatgcac tattctcaac
1081 agatcacggt cagtctagca cagggatatg agagaacttc ttcccctaag cctcgattca
1141 agagctatgc ctacacacag gctgcttatg tcaccacctc tgaccctaca cggagcccat
1201 ttccttcaca gcatttggaa gctcctgaag acaagtcatt tggcagttca ttgatggaga
1261 gtgaagtaaa cctggaccgt tatcaaacag ctttagaaga agtattatcg tggcttcttt
1321 ctgctgagga cacattgcaa gcacaaggag agatttctaa tgatgtggaa gtggtgaaag
1381 accagtttca tactcatgag gggtacatga tggatttgac agcccatcag ggccgggttg
1441 gtaatattct acaattggga agtaagctga ttggaacagg aaaattatca gaagatgaag
1501 aaactgaagt acaagagcag atgaatctcc taaattcaag atgggaatgc ctcagggtag
1561 ctagcatgga aaaacaaagc aatttacata gagttttaat ggatctccag aatcagaaac
1621 tgaaagagtt gaatgactgg ctaacaaaaa cagaagaaag aacaaggaaa atggaggaag
1681 agcctcttgg acctgatctt gaagacctaa aacgccaagt acaacaacat aaggtgcttc
1741 aagaagatct agaacaagaa caagtcaggg tcaattctct cactcacatg gtggtggtag
1801 ttgatgaatc tagtggagat cacgcaactg ctgctttgga agaacaactt aaggtattgg
1861 gagatcgatg ggcaaacatc tgtagatgga cagaagaccg ctgggttctt ttacaagaca
1921 tccttctcaa atggcaacgt cttactgaag aacagtgcct ttttagtgca tggctttcag
1981 aaaaagaaga tgcagtgaac aagattcaca caactggctt taaagatcaa aatgaaatgt
2041 tatcaagtct tcaaaaactg gccgttttaa aagcggatct agaaaagaaa aagcaatcca
2101 tgggcaaact gtattcactc aaacaagatc ttctttcaac actgaagaat aagtcagtga
2161 cccagaagac ggaagcatgg ctggataact ttgcccggtg ttgggataat ttagtccaaa
2221 aacttgaaaa gagtacagca cagatttcac aggctgtcac caccactcag ccatcactaa
2281 cacagacaac tgtaatggaa acagtaacta cggtgaccac aagggaacag atcctggtaa
2341 agcatgctca agaggaactt ccaccaccac ctccccaaaa gaagaggcag attactgtgg
2401 attctgaaat taggaaaagg ttggatgttg atataactga acttcacagc tggattactc
2461 gctcagaagc tgtgttgcag agtcctgaat ttgcaatctt tcggaaggaa ggcaacttct
2521 cagacttaaa agaaaaagtc aatgccatag agcgagaaaa agctgagaag ttcagaaaac
2581 tgcaagatgc cagcagatca gctcaggccc tggtggaaca gatggtgaat gagggtgtta
2641 atgcagatag catcaaacaa gcctcagaac aactgaacag ccggtggatc gaattctgcc
2701 agttgctaag tgagagactt aactggctgg agtatcagaa caacatcatc gctttctata
2761 atcagctaca acaattggag cagatgacaa ctactgctga aaactggttg aaaatccaac
2821 ccaccacccc atcagagcca acagcaatta aaagtcagtt aaaaatttgt aaggatgaag
2881 tcaaccggct atcaggtctt caacctcaaa ttgaacgatt aaaaattcaa agcatagccc
2941 tgaaagagaa aggacaagga cccatgttcc tggatgcaga ctttgtggcc tttacaaatc
3001 attttaagca agtcttttct gatgtgcagg ccagagagaa agagctacag acaatttttg
3061 acactttgcc accaatgcgc tatcaggaga ccatgagtgc catcaggaca tgggtccagc
3121 agtcagaaac caaactctcc atacctcaac ttagtgtcac cgactatgaa atcatggagc
3181 agagactcgg ggaattgcag gctttacaaa gttctctgca agagcaacaa agtggcctat
3241 actatctcag caccactgtg aaagagatgt cgaagaaagc gccctctgaa attagccgga
3301 aatatcaatc agaatttgaa gaaattgagg gacgctggaa gaagctctcc tcccagctgg
3361 ttgagcattg tcaaaagcta gaggagcaaa tgaataaact ccgaaaaatt cagaatcaca
3421 tacaaaccct gaagaaatgg atggctgaag ttgatgtttt tctgaaggag gaatggcctg
3481 cccttgggga ttcagaaatt ctaaaaaagc agctgaaaca gtgcagactt ttagtcagtg
3541 atattcagac aattcagccc agtctaaaca gtgtcaatga aggtgggcag aagataaaga
3601 atgaagcaga gccagagttt gcttcgagac ttgagacaga actcaaagaa cttaacactc
3661 agtgggatca catgtgccaa caggtctatg ccagaaagga ggccttgaag ggaggtttgg
3721 agaaaactgt aagcctccag aaagatctat cagagatgca cgaatggatg acacaagctg
3781 aagaagagta tcttgagaga gattttgaat ataaaactcc agatgaatta cagaaagcag
3841 ttgaagagat gaagagagct aaagaagagg cccaacaaaa agaagcgaaa gtgaaactcc
3901 ttactgagtc tgtaaatagt gtcatagctc aagctccacc tgtagcacaa gaggccttaa
3961 aaaaggaact tgaaactcta accaccaact accagtggct ctgcactagg ctgaatggga
4021 aatgcaagac tttggaagaa gtttgggcat gttggcatga gttattgtca tacttggaga
4081 aagcaaacaa gtggctaaat gaagtagaat ttaaacttaa aaccactgaa aacattcctg
4141 gcggagctga ggaaatctct gaggtgctag attcacttga aaatttgatg cgacattcag
4201 aggataaccc aaatcagatt cgcatattgg cacagaccct aacagatggc ggagtcatgg
4261 atgagctaat caatgaggaa cttgagacat ttaattctcg ttggagggaa ctacatgaag
4321 aggctgtaag gaggcaaaag ttgcttgaac agagcatcca gtctgcccag gagactgaaa
4381 aatccttaca cttaatccag gagtccctca cattcattga caagcagttg gcagcttata
4441 ttgcagacaa ggtggacgca gctcaaatgc ctcaggaagc ccagaaaatc caatctgatt
4501 tgacaagtca tgagatcagt ttagaagaaa tgaagaaaca taatcagggg aaggaggctg
4561 cccaaagagt cctgtctcag attgatgttg cacagaaaaa attacaagat gtctccatga
4621 agtttcgatt attccagaaa ccagccaatt ttgagcagcg tctacaagaa agtaagatga
4681 ttttagatga agtgaagatg cacttgcctg cattggaaac aaagagtgtg gaacaggaag
4741 tagtacagtc acagctaaat cattgtgtga acttgtataa aagtctgagt gaagtgaagt
4801 ctgaagtgga aatggtgata aagactggac gtcagattgt acagaaaaag cagacggaaa
4861 atcccaaaga acttgatgaa agagtaacag ctttgaaatt gcattataat gagctgggag
4921 caaaggtaac agaaagaaag caacagttgg agaaatgctt gaaattgtcc cgtaagatgc
4981 gaaaggaaat gaatgtcttg acagaatggc tggcagctac agatatggaa ttgacaaaga
5041 gatcagcagt tgaaggaatg cctagtaatt tggattctga agttgcctgg ggaaaggcta
5101 ctcaaaaaga gattgagaaa cagaaggtgc acctgaagag tatcacagag gtaggagagg
5161 ccttgaaaac agttttgggc aagaaggaga cgttggtgga agataaactc agtcttctga
5221 atagtaactg gatagctgtc acctcccgag cagaagagtg gttaaatctt ttgttggaat
5281 accagaaaca catggaaact tttgaccaga atgtggacca catcacaaag tggatcattc
5341 aggctgacac acttttggat gaatcagaga aaaagaaacc ccagcaaaaa gaagacgtgc
5401 ttaagcgttt aaaggcagaa ctgaatgaca tacgcccaaa ggtggactct acacgtgacc
5461 aagcagcaaa cttgatggca aaccgcggtg accactgcag gaaattagta gagccccaaa
5521 tctcagagct caaccatcga tttgcagcca tttcacacag aattaagact ggaaaggcct
5581 ccattccttt gaaggaattg gagcagttta actcagatat acaaaaattg cttgaaccac
5641 tggaggctga aattcagcag ggggtgaatc tgaaagagga agacttcaat aaagatatga
5701 atgaagacaa tgagggtact gtaaaagaat tgttgcaaag aggagacaac ttacaacaaa
5761 gaatcacaga tgagagaaag cgagaggaaa taaagataaa acagcagctg ttacagacaa
5821 aacataatgc tctcaaggat ttgaggtctc aaagaagaaa aaaggctcta gaaatttctc
5881 atcagtggta tcagtacaag aggcaggctg atgatctcct gaaatgcttg gatgacattg
5941 aaaaaaaatt agccagccta cctgagccca gagatgaaag gaaaataaag gaaattgatc
6001 gggaattgca gaagaagaaa gaggagctga atgcagtgcg taggcaagct gagggcttgt
6061 ctgaggatgg ggccgcaatg gcagtggagc caactcagat ccagctcagc aagcgctggc
6121 gggaaattga gagcaaattt gctcagtttc gaagactcaa ctttgcacaa attcacactg
6181 tccgtgaaga aacgatgatg gtgatgactg aagacatgcc tttggaaatt tcttatgtgc
6241 cttctactta tttgactgaa atcactcatg tctcacaagc cctattagaa gtggaacaac
6301 ttctcaatgc tcctgacctc tgtgctaagg actttgaaga tctctttaag caagaggagt
6361 ctctgaagaa tataaaagat agtctacaac aaagctcagg tcggattgac attattcata
6421 gcaagaagac agcagcattg caaagtgcaa cgcctgtgga aagggtgaag ctacaggaag
6481 ctctctccca gcttgatttc caatgggaaa aagttaacaa aatgtacaag gaccgacaag
6541 ggcgatttga cagatctgtt gagaaatggc ggcgttttca ttatgatata aagatattta
6601 atcagtggct aacagaagct gaacagtttc tcagaaagac acaaattcct gagaattggg
6661 aacatgctaa atacaaatgg tatcttaagg aactccagga tggcattggg cagcggcaaa
6721 ctgttgtcag aacattgaat gcaactgggg aagaaataat tcagcaatcc tcaaaaacag
6781 atgccagtat tctacaggaa aaattgggaa gcctgaatct gcggtggcag gaggtctgca
6841 aacagctgtc agacagaaaa aagaggctag aagaacaaaa gaatatcttg tcagaatttc
6901 aaagagattt aaatgaattt gttttatggt tggaggaagc agataacatt gctagtatcc
6961 cacttgaacc tggaaaagag cagcaactaa aagaaaagct tgagcaagtc aagttactgg
7021 tggaagagtt gcccctgcgc cagggaattc tcaaacaatt aaatgaaact ggaggacccg
7081 tgcttgtaag tgctcccata agcccagaag agcaagataa acttgaaaat aagctcaagc
7141 agacaaatct ccagtggata aaggtttcca gagctttacc tgagaaacaa ggagaaattg
7201 aagctcaaat aaaagacctt gggcagcttg aaaaaaagct tgaagacctt gaagagcagt
7261 taaatcatct gctgctgtgg ttatctccta ttaggaatca gttggaaatt tataaccaac
7321 caaaccaaga aggaccattt gacgttcagg aaactgaaat agcagttcaa gctaaacaac
7381 cggatgtgga agagattttg tctaaagggc agcatttgta caaggaaaaa ccagccactc
7441 agccagtgaa gaggaagtta gaagatctga gctctgagtg gaaggcggta aaccgtttac
7501 ttcaagagct gagggcaaag cagcctgacc tagctcctgg actgaccact attggagcct
7561 ctcctactca gactgttact ctggtgacac aacctgtggt tactaaggaa actgccatct
7621 ccaaactaga aatgccatct tccttgatgt tggaggtacc tgctctggca gatttcaacc
7681 gggcttggac agaacttacc gactggcttt ctctgcttga tcaagttata aaatcacaga
7741 gggtgatggt gggtgacctt gaggatatca acgagatgat catcaagcag aaggcaacaa
7801 tgcaggattt ggaacagagg cgtccccagt tggaagaact cattaccgct gcccaaaatt
7861 tgaaaaacaa gaccagcaat caagaggcta gaacaatcat tacggatcga attgaaagaa
7921 ttcagaatca gtgggatgaa gtacaagaac accttcagaa ccggaggcaa cagttgaatg
7981 aaatgttaaa ggattcaaca caatggctgg aagctaagga agaagctgag caggtcttag
8041 gacaggccag agccaagctt gagtcatgga aggagggtcc ctatacagta gatgcaatcc
8101 aaaagaaaat cacagaaacc aagcagttgg ccaaagacct ccgccagtgg cagacaaatg
8161 tagatgtggc aaatgacttg gccctgaaac ttctccggga ttattctgca gatgatacca
8221 gaaaagtcca catgataaca gagaatatca atgcctcttg gagaagcatt cataaaaggg
8281 tgagtgagcg agaggctgct ttggaagaaa ctcatagatt actgcaacag ttccccctgg
8341 acctggaaaa gtttcttgcc tggcttacag aagctgaaac aactgccaat gtcctacagg
8401 atgctacccg taaggaaagg ctcctagaag actccaaggg agtaaaagag ctgatgaaac
8461 aatggcaaga cctccaaggt gaaattgaag ctcacacaga tgtttatcac aacctggatg
8521 aaaacagcca aaaaatcctg agatccctgg aaggttccga tgatgcagtc ctgttacaaa
8581 gacgtttgga taacatgaac ttcaagtgga gtgaacttcg gaaaaagtct ctcaacatta
8641 ggtcccattt ggaagccagt tctgaccagt ggaagcgtct gcacctttct ctgcaggaac
8701 ttctggtgtg gctacagctg aaagatgatg aattaagccg gcaggcacct attggaggcg
8761 actttccagc agttcagaag cagaacgatg tacatagggc cttcaagagg gaattgaaaa
8821 ctaaagaacc tgtaatcatg agtactcttg agactgtacg aatatttctg acagagcagc
8881 ctttggaagg actagagaaa ctctaccagg agcccagaga gctgcctcct gaggagagag
8941 cccagaatgt cactcggctt ctacgaaagc aggctgagga ggtcaatact gagtgggaaa
9001 aattgaacct gcactccgct gactggcaga gaaaaataga tgagaccctt gaaagactcc
9061 aggaacttca agaggccacg gatgagctgg acctcaagct gcgccaagct gaggtgatca
9121 agggatcctg gcagcccgtg ggcgatctcc tcattgactc tctccaagat cacctcgaga
9181 aagtcaaggc acttcgagga gaaattgcgc ctctgaaaga gaacgtgagc cacgtcaatg
9241 accttgctcg ccagcttacc actttgggca ttcagctctc accgtataac ctcagcactc
9301 tggaagacct gaacaccaga tggaagcttc tgcaggtggc cgtcgaggac cgagtcaggc
9361 agctgcatga agcccacagg gactttggtc cagcatctca gcactttctt tccacgtctg
9421 tccagggtcc ctgggagaga gccatctcgc caaacaaagt gccctactat atcaaccacg
9481 agactcaaac aacttgctgg gaccatccca aaatgacaga gctctaccag tctttagctg
9541 acctgaataa tgtcagattc tcagcttata ggactgccat gaaactccga agactgcaga
9601 aggccctttg cttggatctc ttgagcctgt cagctgcatg tgatgccttg gaccagcaca
9661 acctcaagca aaatgaccag cccatggata tcctgcagat tattaattgt ttgaccacta
9721 tttatgaccg cctggagcaa gagcacaaca atttggtcaa cgtccctctc tgcgtggata
9781 tgtgtctgaa ctggctgctg aatgtttatg atacgggacg aacagggagg atccgtgtcc
9841 tgtcttttaa aactggcatc atttccctgt gtaaagcaca tttggaagac aagtacagat
9901 accttttcaa gcaagtggca agttcaacag gattttgtga ccagcgcagg ctgggcctcc
9961 ttctgcatga ttctatccaa attccaagac agttgggtga agttgcatcc tttgggggca
10021 gtaacattga gccaagtgtc cggagctgct tccaatttgc taataataag ccagagatcg
10081 aagcggccct cttcctagac tggatgagac tggaacccca gtccatggtg tggctgcccg
10141 tcctgcacag agtggctgct gcagaaactg ccaagcatca ggccaaatgt aacatctgca
10201 aagagtgtcc aatcattgga ttcaggtaca ggagtctaaa gcactttaat tatgacatct
10261 gccaaagctg ctttttttct ggtcgagttg caaaaggcca taaaatgcac tatcccatgg
10321 tggaatattg cactccgact acatcaggag aagatgttcg agactttgcc aaggtactaa
10381 aaaacaaatt tcgaaccaaa aggtattttg cgaagcatcc ccgaatgggc tacctgccag
10441 tgcagactgt cttagagggg gacaacatgg aaactcccgt tactctgatc aacttctggc
10501 cagtagattc tgcgcctgcc tcgtcccctc agctttcaca cgatgatact cattcacgca
10561 ttgaacatta tgctagcagg ctagcagaaa tggaaaacag caatggatct tatctaaatg
10621 atagcatctc tcctaatgag agcatagatg atgaacattt gttaatccag cattactgcc
10681 aaagtttgaa ccaggactcc cccctgagcc agcctcgtag tcctgcccag atcttgattt
10741 ccttagagag tgaggaaaga ggggagctag agagaatcct agcagatctt gaggaagaaa
10801 acaggaatct gcaagcagaa tatgaccgtc taaagcagca gcacgaacat aaaggcctgt
10861 ccccactgcc gtcccctcct gaaatgatgc ccacctctcc ccagagtccc cgggatgctg
10921 agctcattgc tgaggccaag ctactgcgtc aacacaaagg ccgcctggaa gccaggatgc
10981 aaatcctgga agaccacaat aaacagctgg agtcacagtt acacaggcta aggcagctgc
11041 tggagcaacc ccaggcagag gccaaagtga atggcacaac ggtgtcctct ccttctacct
11101 ctctacagag gtccgacagc agtcagccta tgctgctccg agtggttggc agtcaaactt
11161 cggactccat gggtgaggaa gatcttctca gtcctcccca ggacacaagc acagggttag
11221 aggaggtgat ggagcaactc aacaactcct tccctagttc aagaggaaga aatacccctg
11281 gaaagccaat gagagaggac acaatgtagg aagtcttttc cacatggcag atgatttggg
11341 cagagcgatg gagtccttag tatcagtcat gacagatgaa gaaggagcag aataaatgtt
11401 ttacaactcc tgattcccgc atggttttta taatattcat acaacaaaga ggattagaca
11461 gtaagagttt acaagaaata aatctatatt tttgtgaagg gtagtggtat tatactgtag
11521 atttcagtag tttctaagtc tgttattgtt ttgttaacaa tggcaggttt tacacgtcta
11581 tgcaattgta caaaaaagtt ataagaaaac tacatgtaaa atcttgatag ctaaataact
11641 tgccatttct ttatatggaa cgcattttgg gttgtttaaa aatttataac agttataaag
11701 aaagattgta aactaaagtg tgctttataa aaaaaagttg tttataaaaa cccctaaaaa
11761 caaaacaaac acacacacac acacatacac acacacacac aaaactttga ggcagcgcat
11821 tgttttgcat ccttttggcg tgatatccat atgaaattca tggctttttc tttttttgca
11881 tattaaagat aagacttcct ctaccaccac accaaatgac tactacacac tgctcatttg
11941 agaactgtca gctgagtggg gcaggcttga gttttcattt catatatcta tatgtctata
12001 agtatataaa tactatagtt atatagataa agagatacga atttctatag actgactttt
12061 tccatttttt aaatgttcat gtcacatcct aatagaaaga aattacttct agtcagtcat
12121 ccaggcttac ctgcttggtc tagaatggat ttttcccgga gccggaagcc aggaggaaac
12181 tacaccacac taaaacattg tctacagctc cagatgtttc tcattttaaa caactttcca
12241 ctgacaacga aagtaaagta aagtattgga tttttttaaa gggaacatgt gaatgaatac
12301 acaggactta ttatatcaga gtgagtaatc ggttggttgg ttgattgatt gattgattga
12361 tacattcagc ttcctgctgc tagcaatgcc acgatttaga tttaatgatg cttcagtgga
12421 aatcaatcag aaggtattct gaccttgtga acatcagaag gtatttttta actcccaagc
12481 agtagcagga cgatgatagg gctggagggc tatggattcc cagcccatcc ctgtgaagga
12541 gtaggccact ctttaagtga aggattggat gattgttcat aatacataaa gttctctgta
12601 attacaacta aattattatg ccctcttctc acagtcaaaa ggaactgggt ggtttggttt
12661 ttgttgcttt tttagattta ttgtcccatg tgggatgagt ttttaaatgc cacaagacat
12721 aatttaaaat aaataaactt tgggaaaagg tgtaagacag tagccccatc acatttgtga
12781 tactgacagg tatcaaccca gaagcccatg aactgtgttt ccatcctttg catttctctg
12841 cgagtagttc cacacaggtt tgtaagtaag taagaaagaa ggcaaattga ttcaaatgtt
12901 acaaaaaaac ccttcttggt ggattagaca ggttaaatat ataaacaaac aaacaaaaat
12961 tgctcaaaaa agaggagaaa agctcaagag gaaaagctaa ggactggtag gaaaaagctt
13021 tactctttca tgccatttta tttctttttg atttttaaat cattcattca atagatacca
13081 ccgtgtgacc tataattttg caaatctgtt acctctgaca tcaagtgtaa ttagcttttg
13141 gagagtgggc tgacatcaag tgtaattagc ttttggagag tgggttttgt ccattattaa
13201 taattaatta attaacatca aacacggctt ctcatgctat ttctacctca ctttggtttt
13261 ggggtgttcc tgataattgt gcacacctga gttcacagct tcaccacttg tccattgcgt
13321 tattttcttt ttcctttata attctttctt tttccttcat aattttcaaa agaaaaccca
13381 aagctctaag gtaacaaatt accaaattac atgaagattt ggtttttgtc ttgcattttt
13441 ttcctttatg tgacgctgga ccttttcttt acccaaggat ttttaaaact cagatttaaa
13501 acaaggggtt actttacatc ctactaagaa gtttaagtaa gtaagtttca ttctaaaatc
13561 agaggtaaat agagtgcata aataattttg ttttaatctt tttgtttttc ttttagacac
13621 attagctctg gagtgagtct gtcataatat ttgaacaaaa attgagagct ttattgctgc
13681 attttaagca taattaattt ggacattatt tcgtgttgtg ttctttataa ccaccgagta
13741 ttaaactgta aatcataatg taactgaagc ataaacatca catggcatgt tttgtcattg
13801 ttttcaggta ctgagttctt acttgagtat cataatatat tgtgttttaa caccaacact
13861 gtaacattta cgaattattt ttttaaactt cagttttact gcattttcac aacatatcag
13921 acttcaccaa atatatgcct tactattgta ttatagtact gctttactgt gtatctcaat
13981 aaagcacgca gttatgttac
LOCUS Dp427p2 14083 bp mRNA PRI 02-APR-2006
DEFINITION Human dystrophin cDNA isoform Dp427p2 (Purkinje cells).
ACCESSION Dp427p2
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 283 to 14083)
AUTHORS Koenig,M., Monaco,A.P. and Kunkel,L.M.
TITLE The complete sequence of dystrophin predicts a rod-shaped
cytoskeletal protein
JOURNAL Cell 53, 219-228 (1988)
REFERENCE 2 (bases 1 to 412)
AUTHORS Gorecki,D.C., Monaco,A.P., Derry,J.M., Walker,A.P., Barnard,E.A.
and Barnard,P.J.
TITLE Expression of four alternative dystrophin transcripts in brain
regions regulated by different promoters
JOURNAL Hum. Mol. Genet. 1 (7), 505-510 (1992)
MEDLINE 93338441
REFERENCE 3 (bases 2 to 377)
AUTHORS Holder,E., Maeda,M. and Bies,R.D.
TITLE Expression and regulation of the dystrophin Purkinje promoter in
human skeletal muscle, heart, and brain
JOURNAL Hum. Genet. 97 (2), 232-239 (1996)
MEDLINE 96163501
REFERENCE 4 (bases 1 to 14083)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
COMMENT Constructed consensus sequence of S64152, S81419 and M18533.
Transcript has unknown coding capacity.
FEATURES Location/Qualifiers
source 1..14083
/organism="Homo sapiens"
/db_xref="taxon:9606"
polyA_signal 14061..14066
polyA_site 14083
BASE COUNT 4645 a 2814 c 3158 g 3466 t
ORIGIN
1 atgctgtctg tgaagctgaa tctgtgagaa cacctcacta ttcacggcaa ccggagtgga
61 agaaacaggt gcaaaaagat tgtgtgtttg tctgcttttg tgaggctggt cagagattct
121 gtgcctgctt tatctgtgct tggctatgac tctacctcca ggtttaccat accccataga
181 atgtgtaaga gaaaagtacc aacagggaaa tcagcaaaaa gctttcctat gaaggtgtgt
241 agccagcctc cgcagaattt gaaatgtctg aggtctcatc t ggtgagta aaagctgcag
301 ataaatgcaaca gccattcaga agaatgataa attccacaag cattcagaag caggcttccc
361 taaagatgaa agagaagatg ttcaaaagaa aacattcaca aaatgggtaa atgcacaatt
421 ttctaagttt gggaagcagc atattgagaa cctcttcagt gacctacagg atgggaggcg
481 cctcctagac ctcctcgaag gcctgacagg gcaaaaactg ccaaaagaaa aaggatccac
541 aagagttcat gccctgaaca atgtcaacaa ggcactgcgg gttttgcaga acaataatgt
601 tgatttagtg aatattggaa gtactgacat cgtagatgga aatcataaac tgactcttgg
661 tttgatttgg aatataatcc tccactggca ggtcaaaaat gtaatgaaaa atatcatggc
721 tggattgcaa caaaccaaca gtgaaaagat tctcctgagc tgggtccgac aatcaactcg
781 taattatcca caggttaatg taatcaactt caccaccagc tggtctgatg gcctggcttt
841 gaatgctctc atccatagtc ataggccaga cctatttgac tggaatagtg tggtttgcca
901 gcagtcagcc acacaacgac tggaacatgc attcaacatc gccagatatc aattaggcat
961 agagaaacta ctcgatcctg aagatgttga taccacctat ccagataaga agtccatctt
1021 aatgtacatc acatcactct tccaagtttt gcctcaacaa gtgagcattg aagccatcca
1081 ggaagtggaa atgttgccaa ggccacctaa agtgactaaa gaagaacatt ttcagttaca
1141 tcatcaaatg cactattctc aacagatcac ggtcagtcta gcacagggat atgagagaac
1201 ttcttcccct aagcctcgat tcaagagcta tgcctacaca caggctgctt atgtcaccac
1261 ctctgaccct acacggagcc catttccttc acagcatttg gaagctcctg aagacaagtc
1321 atttggcagt tcattgatgg agagtgaagt aaacctggac cgttatcaaa cagctttaga
1381 agaagtatta tcgtggcttc tttctgctga ggacacattg caagcacaag gagagatttc
1441 taatgatgtg gaagtggtga aagaccagtt tcatactcat gaggggtaca tgatggattt
1501 gacagcccat cagggccggg ttggtaatat tctacaattg ggaagtaagc tgattggaac
1561 aggaaaatta tcagaagatg aagaaactga agtacaagag cagatgaatc tcctaaattc
1621 aagatgggaa tgcctcaggg tagctagcat ggaaaaacaa agcaatttac atagagtttt
1681 aatggatctc cagaatcaga aactgaaaga gttgaatgac tggctaacaa aaacagaaga
1741 aagaacaagg aaaatggagg aagagcctct tggacctgat cttgaagacc taaaacgcca
1801 agtacaacaa cataaggtgc ttcaagaaga tctagaacaa gaacaagtca gggtcaattc
1861 tctcactcac atggtggtgg tagttgatga atctagtgga gatcacgcaa ctgctgcttt
1921 ggaagaacaa cttaaggtat tgggagatcg atgggcaaac atctgtagat ggacagaaga
1981 ccgctgggtt cttttacaag acatccttct caaatggcaa cgtcttactg aagaacagtg
2041 cctttttagt gcatggcttt cagaaaaaga agatgcagtg aacaagattc acacaactgg
2101 ctttaaagat caaaatgaaa tgttatcaag tcttcaaaaa ctggccgttt taaaagcgga
2161 tctagaaaag aaaaagcaat ccatgggcaa actgtattca ctcaaacaag atcttctttc
2221 aacactgaag aataagtcag tgacccagaa gacggaagca tggctggata actttgcccg
2281 gtgttgggat aatttagtcc aaaaacttga aaagagtaca gcacagattt cacaggctgt
2341 caccaccact cagccatcac taacacagac aactgtaatg gaaacagtaa ctacggtgac
2401 cacaagggaa cagatcctgg taaagcatgc tcaagaggaa cttccaccac cacctcccca
2461 aaagaagagg cagattactg tggattctga aattaggaaa aggttggatg ttgatataac
2521 tgaacttcac agctggatta ctcgctcaga agctgtgttg cagagtcctg aatttgcaat
2581 ctttcggaag gaaggcaact tctcagactt aaaagaaaaa gtcaatgcca tagagcgaga
2641 aaaagctgag aagttcagaa aactgcaaga tgccagcaga tcagctcagg ccctggtgga
2701 acagatggtg aatgagggtg ttaatgcaga tagcatcaaa caagcctcag aacaactgaa
2761 cagccggtgg atcgaattct gccagttgct aagtgagaga cttaactggc tggagtatca
2821 gaacaacatc atcgctttct ataatcagct acaacaattg gagcagatga caactactgc
2881 tgaaaactgg ttgaaaatcc aacccaccac cccatcagag ccaacagcaa ttaaaagtca
2941 gttaaaaatt tgtaaggatg aagtcaaccg gctatcaggt cttcaacctc aaattgaacg
3001 attaaaaatt caaagcatag ccctgaaaga gaaaggacaa ggacccatgt tcctggatgc
3061 agactttgtg gcctttacaa atcattttaa gcaagtcttt tctgatgtgc aggccagaga
3121 gaaagagcta cagacaattt ttgacacttt gccaccaatg cgctatcagg agaccatgag
3181 tgccatcagg acatgggtcc agcagtcaga aaccaaactc tccatacctc aacttagtgt
3241 caccgactat gaaatcatgg agcagagact cggggaattg caggctttac aaagttctct
3301 gcaagagcaa caaagtggcc tatactatct cagcaccact gtgaaagaga tgtcgaagaa
3361 agcgccctct gaaattagcc ggaaatatca atcagaattt gaagaaattg agggacgctg
3421 gaagaagctc tcctcccagc tggttgagca ttgtcaaaag ctagaggagc aaatgaataa
3481 actccgaaaa attcagaatc acatacaaac cctgaagaaa tggatggctg aagttgatgt
3541 ttttctgaag gaggaatggc ctgcccttgg ggattcagaa attctaaaaa agcagctgaa
3601 acagtgcaga cttttagtca gtgatattca gacaattcag cccagtctaa acagtgtcaa
3661 tgaaggtggg cagaagataa agaatgaagc agagccagag tttgcttcga gacttgagac
3721 agaactcaaa gaacttaaca ctcagtggga tcacatgtgc caacaggtct atgccagaaa
3781 ggaggccttg aagggaggtt tggagaaaac tgtaagcctc cagaaagatc tatcagagat
3841 gcacgaatgg atgacacaag ctgaagaaga gtatcttgag agagattttg aatataaaac
3901 tccagatgaa ttacagaaag cagttgaaga gatgaagaga gctaaagaag aggcccaaca
3961 aaaagaagcg aaagtgaaac tccttactga gtctgtaaat agtgtcatag ctcaagctcc
4021 acctgtagca caagaggcct taaaaaagga acttgaaact ctaaccacca actaccagtg
4081 gctctgcact aggctgaatg ggaaatgcaa gactttggaa gaagtttggg catgttggca
4141 tgagttattg tcatacttgg agaaagcaaa caagtggcta aatgaagtag aatttaaact
4201 taaaaccact gaaaacattc ctggcggagc tgaggaaatc tctgaggtgc tagattcact
4261 tgaaaatttg atgcgacatt cagaggataa cccaaatcag attcgcatat tggcacagac
4321 cctaacagat ggcggagtca tggatgagct aatcaatgag gaacttgaga catttaattc
4381 tcgttggagg gaactacatg aagaggctgt aaggaggcaa aagttgcttg aacagagcat
4441 ccagtctgcc caggagactg aaaaatcctt acacttaatc caggagtccc tcacattcat
4501 tgacaagcag ttggcagctt atattgcaga caaggtggac gcagctcaaa tgcctcagga
4561 agcccagaaa atccaatctg atttgacaag tcatgagatc agtttagaag aaatgaagaa
4621 acataatcag gggaaggagg ctgcccaaag agtcctgtct cagattgatg ttgcacagaa
4681 aaaattacaa gatgtctcca tgaagtttcg attattccag aaaccagcca attttgagca
4741 gcgtctacaa gaaagtaaga tgattttaga tgaagtgaag atgcacttgc ctgcattgga
4801 aacaaagagt gtggaacagg aagtagtaca gtcacagcta aatcattgtg tgaacttgta
4861 taaaagtctg agtgaagtga agtctgaagt ggaaatggtg ataaagactg gacgtcagat
4921 tgtacagaaa aagcagacgg aaaatcccaa agaacttgat gaaagagtaa cagctttgaa
4981 attgcattat aatgagctgg gagcaaaggt aacagaaaga aagcaacagt tggagaaatg
5041 cttgaaattg tcccgtaaga tgcgaaagga aatgaatgtc ttgacagaat ggctggcagc
5101 tacagatatg gaattgacaa agagatcagc agttgaagga atgcctagta atttggattc
5161 tgaagttgcc tggggaaagg ctactcaaaa agagattgag aaacagaagg tgcacctgaa
5221 gagtatcaca gaggtaggag aggccttgaa aacagttttg ggcaagaagg agacgttggt
5281 ggaagataaa ctcagtcttc tgaatagtaa ctggatagct gtcacctccc gagcagaaga
5341 gtggttaaat cttttgttgg aataccagaa acacatggaa acttttgacc agaatgtgga
5401 ccacatcaca aagtggatca ttcaggctga cacacttttg gatgaatcag agaaaaagaa
5461 accccagcaa aaagaagacg tgcttaagcg tttaaaggca gaactgaatg acatacgccc
5521 aaaggtggac tctacacgtg accaagcagc aaacttgatg gcaaaccgcg gtgaccactg
5581 caggaaatta gtagagcccc aaatctcaga gctcaaccat cgatttgcag ccatttcaca
5641 cagaattaag actggaaagg cctccattcc tttgaaggaa ttggagcagt ttaactcaga
5701 tatacaaaaa ttgcttgaac cactggaggc tgaaattcag cagggggtga atctgaaaga
5761 ggaagacttc aataaagata tgaatgaaga caatgagggt actgtaaaag aattgttgca
5821 aagaggagac aacttacaac aaagaatcac agatgagaga aagcgagagg aaataaagat
5881 aaaacagcag ctgttacaga caaaacataa tgctctcaag gatttgaggt ctcaaagaag
5941 aaaaaaggct ctagaaattt ctcatcagtg gtatcagtac aagaggcagg ctgatgatct
6001 cctgaaatgc ttggatgaca ttgaaaaaaa attagccagc ctacctgagc ccagagatga
6061 aaggaaaata aaggaaattg atcgggaatt gcagaagaag aaagaggagc tgaatgcagt
6121 gcgtaggcaa gctgagggct tgtctgagga tggggccgca atggcagtgg agccaactca
6181 gatccagctc agcaagcgct ggcgggaaat tgagagcaaa tttgctcagt ttcgaagact
6241 caactttgca caaattcaca ctgtccgtga agaaacgatg atggtgatga ctgaagacat
6301 gcctttggaa atttcttatg tgccttctac ttatttgact gaaatcactc atgtctcaca
6361 agccctatta gaagtggaac aacttctcaa tgctcctgac ctctgtgcta aggactttga
6421 agatctcttt aagcaagagg agtctctgaa gaatataaaa gatagtctac aacaaagctc
6481 aggtcggatt gacattattc atagcaagaa gacagcagca ttgcaaagtg caacgcctgt
6541 ggaaagggtg aagctacagg aagctctctc ccagcttgat ttccaatggg aaaaagttaa
6601 caaaatgtac aaggaccgac aagggcgatt tgacagatct gttgagaaat ggcggcgttt
6661 tcattatgat ataaagatat ttaatcagtg gctaacagaa gctgaacagt ttctcagaaa
6721 gacacaaatt cctgagaatt gggaacatgc taaatacaaa tggtatctta aggaactcca
6781 ggatggcatt gggcagcggc aaactgttgt cagaacattg aatgcaactg gggaagaaat
6841 aattcagcaa tcctcaaaaa cagatgccag tattctacag gaaaaattgg gaagcctgaa
6901 tctgcggtgg caggaggtct gcaaacagct gtcagacaga aaaaagaggc tagaagaaca
6961 aaagaatatc ttgtcagaat ttcaaagaga tttaaatgaa tttgttttat ggttggagga
7021 agcagataac attgctagta tcccacttga acctggaaaa gagcagcaac taaaagaaaa
7081 gcttgagcaa gtcaagttac tggtggaaga gttgcccctg cgccagggaa ttctcaaaca
7141 attaaatgaa actggaggac ccgtgcttgt aagtgctccc ataagcccag aagagcaaga
7201 taaacttgaa aataagctca agcagacaaa tctccagtgg ataaaggttt ccagagcttt
7261 acctgagaaa caaggagaaa ttgaagctca aataaaagac cttgggcagc ttgaaaaaaa
7321 gcttgaagac cttgaagagc agttaaatca tctgctgctg tggttatctc ctattaggaa
7381 tcagttggaa atttataacc aaccaaacca agaaggacca tttgacgttc aggaaactga
7441 aatagcagtt caagctaaac aaccggatgt ggaagagatt ttgtctaaag ggcagcattt
7501 gtacaaggaa aaaccagcca ctcagccagt gaagaggaag ttagaagatc tgagctctga
7561 gtggaaggcg gtaaaccgtt tacttcaaga gctgagggca aagcagcctg acctagctcc
7621 tggactgacc actattggag cctctcctac tcagactgtt actctggtga cacaacctgt
7681 ggttactaag gaaactgcca tctccaaact agaaatgcca tcttccttga tgttggaggt
7741 acctgctctg gcagatttca accgggcttg gacagaactt accgactggc tttctctgct
7801 tgatcaagtt ataaaatcac agagggtgat ggtgggtgac cttgaggata tcaacgagat
7861 gatcatcaag cagaaggcaa caatgcagga tttggaacag aggcgtcccc agttggaaga
7921 actcattacc gctgcccaaa atttgaaaaa caagaccagc aatcaagagg ctagaacaat
7981 cattacggat cgaattgaaa gaattcagaa tcagtgggat gaagtacaag aacaccttca
8041 gaaccggagg caacagttga atgaaatgtt aaaggattca acacaatggc tggaagctaa
8101 ggaagaagct gagcaggtct taggacaggc cagagccaag cttgagtcat ggaaggaggg
8161 tccctataca gtagatgcaa tccaaaagaa aatcacagaa accaagcagt tggccaaaga
8221 cctccgccag tggcagacaa atgtagatgt ggcaaatgac ttggccctga aacttctccg
8281 ggattattct gcagatgata ccagaaaagt ccacatgata acagagaata tcaatgcctc
8341 ttggagaagc attcataaaa gggtgagtga gcgagaggct gctttggaag aaactcatag
8401 attactgcaa cagttccccc tggacctgga aaagtttctt gcctggctta cagaagctga
8461 aacaactgcc aatgtcctac aggatgctac ccgtaaggaa aggctcctag aagactccaa
8521 gggagtaaaa gagctgatga aacaatggca agacctccaa ggtgaaattg aagctcacac
8581 agatgtttat cacaacctgg atgaaaacag ccaaaaaatc ctgagatccc tggaaggttc
8641 cgatgatgca gtcctgttac aaagacgttt ggataacatg aacttcaagt ggagtgaact
8701 tcggaaaaag tctctcaaca ttaggtccca tttggaagcc agttctgacc agtggaagcg
8761 tctgcacctt tctctgcagg aacttctggt gtggctacag ctgaaagatg atgaattaag
8821 ccggcaggca cctattggag gcgactttcc agcagttcag aagcagaacg atgtacatag
8881 ggccttcaag agggaattga aaactaaaga acctgtaatc atgagtactc ttgagactgt
8941 acgaatattt ctgacagagc agcctttgga aggactagag aaactctacc aggagcccag
9001 agagctgcct cctgaggaga gagcccagaa tgtcactcgg cttctacgaa agcaggctga
9061 ggaggtcaat actgagtggg aaaaattgaa cctgcactcc gctgactggc agagaaaaat
9121 agatgagacc cttgaaagac tccaggaact tcaagaggcc acggatgagc tggacctcaa
9181 gctgcgccaa gctgaggtga tcaagggatc ctggcagccc gtgggcgatc tcctcattga
9241 ctctctccaa gatcacctcg agaaagtcaa ggcacttcga ggagaaattg cgcctctgaa
9301 agagaacgtg agccacgtca atgaccttgc tcgccagctt accactttgg gcattcagct
9361 ctcaccgtat aacctcagca ctctggaaga cctgaacacc agatggaagc ttctgcaggt
9421 ggccgtcgag gaccgagtca ggcagctgca tgaagcccac agggactttg gtccagcatc
9481 tcagcacttt ctttccacgt ctgtccaggg tccctgggag agagccatct cgccaaacaa
9541 agtgccctac tatatcaacc acgagactca aacaacttgc tgggaccatc ccaaaatgac
9601 agagctctac cagtctttag ctgacctgaa taatgtcaga ttctcagctt ataggactgc
9661 catgaaactc cgaagactgc agaaggccct ttgcttggat ctcttgagcc tgtcagctgc
9721 atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac cagcccatgg atatcctgca
9781 gattattaat tgtttgacca ctatttatga ccgcctggag caagagcaca acaatttggt
9841 caacgtccct ctctgcgtgg atatgtgtct gaactggctg ctgaatgttt atgatacggg
9901 acgaacaggg aggatccgtg tcctgtcttt taaaactggc atcatttccc tgtgtaaagc
9961 acatttggaa gacaagtaca gatacctttt caagcaagtg gcaagttcaa caggattttg
10021 tgaccagcgc aggctgggcc tccttctgca tgattctatc caaattccaa gacagttggg
10081 tgaagttgca tcctttgggg gcagtaacat tgagccaagt gtccggagct gcttccaatt
10141 tgctaataat aagccagaga tcgaagcggc cctcttccta gactggatga gactggaacc
10201 ccagtccatg gtgtggctgc ccgtcctgca cagagtggct gctgcagaaa ctgccaagca
10261 tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt ggattcaggt acaggagtct
10321 aaagcacttt aattatgaca tctgccaaag ctgctttttt tctggtcgag ttgcaaaagg
10381 ccataaaatg cactatccca tggtggaata ttgcactccg actacatcag gagaagatgt
10441 tcgagacttt gccaaggtac taaaaaacaa atttcgaacc aaaaggtatt ttgcgaagca
10501 tccccgaatg ggctacctgc cagtgcagac tgtcttagag ggggacaaca tggaaactcc
10561 cgttactctg atcaacttct ggccagtaga ttctgcgcct gcctcgtccc ctcagctttc
10621 acacgatgat actcattcac gcattgaaca ttatgctagc aggctagcag aaatggaaaa
10681 cagcaatgga tcttatctaa atgatagcat ctctcctaat gagagcatag atgatgaaca
10741 tttgttaatc cagcattact gccaaagttt gaaccaggac tcccccctga gccagcctcg
10801 tagtcctgcc cagatcttga tttccttaga gagtgaggaa agaggggagc tagagagaat
10861 cctagcagat cttgaggaag aaaacaggaa tctgcaagca gaatatgacc gtctaaagca
10921 gcagcacgaa cataaaggcc tgtccccact gccgtcccct cctgaaatga tgcccacctc
10981 tccccagagt ccccgggatg ctgagctcat tgctgaggcc aagctactgc gtcaacacaa
11041 aggccgcctg gaagccagga tgcaaatcct ggaagaccac aataaacagc tggagtcaca
11101 gttacacagg ctaaggcagc tgctggagca accccaggca gaggccaaag tgaatggcac
11161 aacggtgtcc tctccttcta cctctctaca gaggtccgac agcagtcagc ctatgctgct
11221 ccgagtggtt ggcagtcaaa cttcggactc catgggtgag gaagatcttc tcagtcctcc
11281 ccaggacaca agcacagggt tagaggaggt gatggagcaa ctcaacaact ccttccctag
11341 ttcaagagga agaaataccc ctggaaagcc aatgagagag gacacaatgt aggaagtctt
11401 ttccacatgg cagatgattt gggcagagcg atggagtcct tagtatcagt catgacagat
11461 gaagaaggag cagaataaat gttttacaac tcctgattcc cgcatggttt ttataatatt
11521 catacaacaa agaggattag acagtaagag tttacaagaa ataaatctat atttttgtga
11581 agggtagtgg tattatactg tagatttcag tagtttctaa gtctgttatt gttttgttaa
11641 caatggcagg ttttacacgt ctatgcaatt gtacaaaaaa gttataagaa aactacatgt
11701 aaaatcttga tagctaaata acttgccatt tctttatatg gaacgcattt tgggttgttt
11761 aaaaatttat aacagttata aagaaagatt gtaaactaaa gtgtgcttta taaaaaaaag
11821 ttgtttataa aaacccctaa aaacaaaaca aacacacaca cacacacata cacacacaca
11881 cacaaaactt tgaggcagcg cattgttttg catccttttg gcgtgatatc catatgaaat
11941 tcatggcttt ttcttttttt gcatattaaa gataagactt cctctaccac cacaccaaat
12001 gactactaca cactgctcat ttgagaactg tcagctgagt ggggcaggct tgagttttca
12061 tttcatatat ctatatgtct ataagtatat aaatactata gttatataga taaagagata
12121 cgaatttcta tagactgact ttttccattt tttaaatgtt catgtcacat cctaatagaa
12181 agaaattact tctagtcagt catccaggct tacctgcttg gtctagaatg gatttttccc
12241 ggagccggaa gccaggagga aactacacca cactaaaaca ttgtctacag ctccagatgt
12301 ttctcatttt aaacaacttt ccactgacaa cgaaagtaaa gtaaagtatt ggattttttt
12361 aaagggaaca tgtgaatgaa tacacaggac ttattatatc agagtgagta atcggttggt
12421 tggttgattg attgattgat tgatacattc agcttcctgc tgctagcaat gccacgattt
12481 agatttaatg atgcttcagt ggaaatcaat cagaaggtat tctgaccttg tgaacatcag
12541 aaggtatttt ttaactccca agcagtagca ggacgatgat agggctggag ggctatggat
12601 tcccagccca tccctgtgaa ggagtaggcc actctttaag tgaaggattg gatgattgtt
12661 cataatacat aaagttctct gtaattacaa ctaaattatt atgccctctt ctcacagtca
12721 aaaggaactg ggtggtttgg tttttgttgc ttttttagat ttattgtccc atgtgggatg
12781 agtttttaaa tgccacaaga cataatttaa aataaataaa ctttgggaaa aggtgtaaga
12841 cagtagcccc atcacatttg tgatactgac aggtatcaac ccagaagccc atgaactgtg
12901 tttccatcct ttgcatttct ctgcgagtag ttccacacag gtttgtaagt aagtaagaaa
12961 gaaggcaaat tgattcaaat gttacaaaaa aacccttctt ggtggattag acaggttaaa
13021 tatataaaca aacaaacaaa aattgctcaa aaaagaggag aaaagctcaa gaggaaaagc
13081 taaggactgg taggaaaaag ctttactctt tcatgccatt ttatttcttt ttgattttta
13141 aatcattcat tcaatagata ccaccgtgtg acctataatt ttgcaaatct gttacctctg
13201 acatcaagtg taattagctt ttggagagtg ggctgacatc aagtgtaatt agcttttgga
13261 gagtgggttt tgtccattat taataattaa ttaattaaca tcaaacacgg cttctcatgc
13321 tatttctacc tcactttggt tttggggtgt tcctgataat tgtgcacacc tgagttcaca
13381 gcttcaccac ttgtccattg cgttattttc tttttccttt ataattcttt ctttttcctt
13441 cataattttc aaaagaaaac ccaaagctct aaggtaacaa attaccaaat tacatgaaga
13501 tttggttttt gtcttgcatt tttttccttt atgtgacgct ggaccttttc tttacccaag
13561 gatttttaaa actcagattt aaaacaaggg gttactttac atcctactaa gaagtttaag
13621 taagtaagtt tcattctaaa atcagaggta aatagagtgc ataaataatt ttgttttaat
13681 ctttttgttt ttcttttaga cacattagct ctggagtgag tctgtcataa tatttgaaca
13741 aaaattgaga gctttattgc tgcattttaa gcataattaa tttggacatt atttcgtgtt
13801 gtgttcttta taaccaccga gtattaaact gtaaatcata atgtaactga agcataaaca
13861 tcacatggca tgttttgtca ttgttttcag gtactgagtt cttacttgag tatcataata
13921 tattgtgttt taacaccaac actgtaacat ttacgaatta tttttttaaa cttcagtttt
13981 actgcatttt cacaacatat cagacttcac caaatatatg ccttactatt gtattatagt
14041 actgctttac tgtgtatctc aataaagcac gcagttatgt tac
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