(last modified April 2, 2006)
Submitted to GenBank
LOCUS Dp260 9773 bp mRNA PRI 20-JAN-1998
DEFINITION Human dystrophin cDNA isoform Dp260-1 (retina).
ACCESSION Dp260
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 96 to 9773)
AUTHORS D'Souza,V.N., Thi Man,N., Morris,G.E., Karges,W., Pillers,D.-A.M.
and Ray,P.N.
TITLE A novel dystrophin isoform is required for normal retinal
electrophysiology
JOURNAL Hum. Mol. Genet. 4, 837-842 (1995)
REFERENCE 2 (bases 1 to 95)
AUTHORS White,R.A.
TITLE Identification of cDNAs encoding two human retinal dystrophin
isoforms: alternative splicing of a complex novel first exon
JOURNAL Unpublished (1995)
REFERENCE 3 (bases 1 to 9773)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
COMMENT Constructed consensus sequence of GenBank U27203 and M18533.
FEATURES Location/Qualifiers
source 1..9773
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp21.2"
5'UTR 1..47
misc_feature 48..95
/note="Region: dystrophin Dp260-1 unique N-terminus"
CDS 48..7082
/codon_start=1
/product="dystrophin Dp260-1"
/translation="MTEIILLIFFPAYFLNAVRRQKLLEQSIQSAQETEKSLHLIQES
LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ
IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ
LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKV
TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKAT
QKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLL
EYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS
TRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQ
KLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKI
KQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR
DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQ
FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL
CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL
DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA
KYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK
QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKL
LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ
GEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA
VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAP
GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS
LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE
ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKL
ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM
ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQR
RLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIG
GDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP
EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR
QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL
SPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISP
NKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLS
LSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL
NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDS
IQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLH
RVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMV
EYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINF
WPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQ
HYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQH
EHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQ
LHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS
PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"
misc_feature <96..5144
/note="Region: central rod domain"
misc_feature <96..125
/note="Region: repeat region 9"
misc_feature 126..413
/note="Region: repeat region 10"
misc_feature 405..728
/note="Region: repeat region 11"
misc_feature 729..1052
/note="Region: repeat region 12"
misc_feature 1053..1358
/note="Region: repeat region 13"
misc_feature 1359..1646
/note="Region: repeat region 14"
misc_feature 1647..1943
/note="Region: repeat region 15"
misc_feature 1998..2327
/note="Region: repeat region 16"
misc_feature 2328..2648
/note="Region: repeat region 17"
misc_feature 2649..2978
/note="Region: repeat region 18"
misc_feature 2979..3293
/note="Region: repeat region 19"
misc_feature 3294..3434
/note="Region: hinge region 3"
misc_feature 3435..3755
/note="Region: repeat region 20"
misc_feature 3756..4082
/note="Region: repeat region 21"
misc_feature 4083..4430
/note="Region: repeat region 22"
misc_feature 4431..4817
/note="Region: repeat region 23"
misc_feature 4818..5144
/note="Region: repeat region 24"
misc_feature 5064..5360
/note="Region: hinge region 4"
misc_feature 5190..5300
/note="Region: WW-domain"
misc_feature 5262..6248
/note="dystroglycan binding site"
misc_feature 5322..5924
/note="Region: Cysteine-rich domain"
misc_feature 5412..5495
/note="Region: EF-hand 1"
misc_feature 5556..5642
/note="Region: EF-hand 2"
misc_feature 5922..7079
/note="Region: Carboxy-terminal region"
misc_feature 5943..6086
/note="Region: ZZ-domain"
misc_feature 6354..6506
/note="alpha1-syntrophin binding site"
misc_feature 6507..6629
/note="beta1-syntrophin binding site"
misc_feature 6507..6629
/note="Region: beta1-syntrophin binding site"
misc_feature 6696..6803
/note="Region: (Leu)6-heptad repeat"
3'UTR 7083..9773
polyA_signal 9751..9756
polyA_site 9773
BASE COUNT 3163 a 1950 c 2176 g 2484 t
ORIGIN
1 ......gaga tcaggaggaa cattcgacct gagaaagaca gattgcaatg actgagatga
61 ttttgctaat tttttttcca gcctatttcc ttaatgctgt aaggaggcaa aagttgcttg
121 aacagagcat ccagtctgcc caggagactg aaaaatcctt acacttaatc caggagtccc
181 tcacattcat tgacaagcag ttggcagctt atattgcaga caaggtggac gcagctcaaa
241 tgcctcagga agcccagaaa atccaatctg atttgacaag tcatgagatc agtttagaag
301 aaatgaagaa acataatcag gggaaggagg ctgcccaaag agtcctgtct cagattgatg
361 ttgcacagaa aaaattacaa gatgtctcca tgaagtttcg attattccag aaaccagcca
421 attttgagca gcgtctacaa gaaagtaaga tgattttaga tgaagtgaag atgcacttgc
481 ctgcattgga aacaaagagt gtggaacagg aagtagtaca gtcacagcta aatcattgtg
541 tgaacttgta taaaagtctg agtgaagtga agtctgaagt ggaaatggtg ataaagactg
601 gacgtcagat tgtacagaaa aagcagacgg aaaatcccaa agaacttgat gaaagagtaa
661 cagctttgaa attgcattat aatgagctgg gagcaaaggt aacagaaaga aagcaacagt
721 tggagaaatg cttgaaattg tcccgtaaga tgcgaaagga aatgaatgtc ttgacagaat
781 ggctggcagc tacagatatg gaattgacaa agagatcagc agttgaagga atgcctagta
841 atttggattc tgaagttgcc tggggaaagg ctactcaaaa agagattgag aaacagaagg
901 tgcacctgaa gagtatcaca gaggtaggag aggccttgaa aacagttttg ggcaagaagg
961 agacgttggt ggaagataaa ctcagtcttc tgaatagtaa ctggatagct gtcacctccc
1021 gagcagaaga gtggttaaat cttttgttgg aataccagaa acacatggaa acttttgacc
1081 agaatgtgga ccacatcaca aagtggatca ttcaggctga cacacttttg gatgaatcag
1141 agaaaaagaa accccagcaa aaagaagacg tgcttaagcg tttaaaggca gaactgaatg
1201 acatacgccc aaaggtggac tctacacgtg accaagcagc aaacttgatg gcaaaccgcg
1261 gtgaccactg caggaaatta gtagagcccc aaatctcaga gctcaaccat cgatttgcag
1321 ccatttcaca cagaattaag actggaaagg cctccattcc tttgaaggaa ttggagcagt
1381 ttaactcaga tatacaaaaa ttgcttgaac cactggaggc tgaaattcag cagggggtga
1441 atctgaaaga ggaagacttc aataaagata tgaatgaaga caatgagggt actgtaaaag
1501 aattgttgca aagaggagac aacttacaac aaagaatcac agatgagaga aagcgagagg
1561 aaataaagat aaaacagcag ctgttacaga caaaacataa tgctctcaag gatttgaggt
1621 ctcaaagaag aaaaaaggct ctagaaattt ctcatcagtg gtatcagtac aagaggcagg
1681 ctgatgatct cctgaaatgc ttggatgaca ttgaaaaaaa attagccagc ctacctgagc
1741 ccagagatga aaggaaaata aaggaaattg atcgggaatt gcagaagaag aaagaggagc
1801 tgaatgcagt gcgtaggcaa gctgagggct tgtctgagga tggggccgca atggcagtgg
1861 agccaactca gatccagctc agcaagcgct ggcgggaaat tgagagcaaa tttgctcagt
1921 ttcgaagact caactttgca caaattcaca ctgtccgtga agaaacgatg atggtgatga
1981 ctgaagacat gcctttggaa atttcttatg tgccttctac ttatttgact gaaatcactc
2041 atgtctcaca agccctatta gaagtggaac aacttctcaa tgctcctgac ctctgtgcta
2101 aggactttga agatctcttt aagcaagagg agtctctgaa gaatataaaa gatagtctac
2161 aacaaagctc aggtcggatt gacattattc atagcaagaa gacagcagca ttgcaaagtg
2221 caacgcctgt ggaaagggtg aagctacagg aagctctctc ccagcttgat ttccaatggg
2281 aaaaagttaa caaaatgtac aaggaccgac aagggcgatt tgacagatct gttgagaaat
2341 ggcggcgttt tcattatgat ataaagatat ttaatcagtg gctaacagaa gctgaacagt
2401 ttctcagaaa gacacaaatt cctgagaatt gggaacatgc taaatacaaa tggtatctta
2461 aggaactcca ggatggcatt gggcagcggc aaactgttgt cagaacattg aatgcaactg
2521 gggaagaaat aattcagcaa tcctcaaaaa cagatgccag tattctacag gaaaaattgg
2581 gaagcctgaa tctgcggtgg caggaggtct gcaaacagct gtcagacaga aaaaagaggc
2641 tagaagaaca aaagaatatc ttgtcagaat ttcaaagaga tttaaatgaa tttgttttat
2701 ggttggagga agcagataac attgctagta tcccacttga acctggaaaa gagcagcaac
2761 taaaagaaaa gcttgagcaa gtcaagttac tggtggaaga gttgcccctg cgccagggaa
2821 ttctcaaaca attaaatgaa actggaggac ccgtgcttgt aagtgctccc ataagcccag
2881 aagagcaaga taaacttgaa aataagctca agcagacaaa tctccagtgg ataaaggttt
2941 ccagagcttt acctgagaaa caaggagaaa ttgaagctca aataaaagac cttgggcagc
3001 ttgaaaaaaa gcttgaagac cttgaagagc agttaaatca tctgctgctg tggttatctc
3061 ctattaggaa tcagttggaa atttataacc aaccaaacca agaaggacca tttgacgttc
3121 aggaaactga aatagcagtt caagctaaac aaccggatgt ggaagagatt ttgtctaaag
3181 ggcagcattt gtacaaggaa aaaccagcca ctcagccagt gaagaggaag ttagaagatc
3241 tgagctctga gtggaaggcg gtaaaccgtt tacttcaaga gctgagggca aagcagcctg
3301 acctagctcc tggactgacc actattggag cctctcctac tcagactgtt actctggtga
3361 cacaacctgt ggttactaag gaaactgcca tctccaaact agaaatgcca tcttccttga
3421 tgttggaggt acctgctctg gcagatttca accgggcttg gacagaactt accgactggc
3481 tttctctgct tgatcaagtt ataaaatcac agagggtgat ggtgggtgac cttgaggata
3541 tcaacgagat gatcatcaag cagaaggcaa caatgcagga tttggaacag aggcgtcccc
3601 agttggaaga actcattacc gctgcccaaa atttgaaaaa caagaccagc aatcaagagg
3661 ctagaacaat cattacggat cgaattgaaa gaattcagaa tcagtgggat gaagtacaag
3721 aacaccttca gaaccggagg caacagttga atgaaatgtt aaaggattca acacaatggc
3781 tggaagctaa ggaagaagct gagcaggtct taggacaggc cagagccaag cttgagtcat
3841 ggaaggaggg tccctataca gtagatgcaa tccaaaagaa aatcacagaa accaagcagt
3901 tggccaaaga cctccgccag tggcagacaa atgtagatgt ggcaaatgac ttggccctga
3961 aacttctccg ggattattct gcagatgata ccagaaaagt ccacatgata acagagaata
4021 tcaatgcctc ttggagaagc attcataaaa gggtgagtga gcgagaggct gctttggaag
4081 aaactcatag attactgcaa cagttccccc tggacctgga aaagtttctt gcctggctta
4141 cagaagctga aacaactgcc aatgtcctac aggatgctac ccgtaaggaa aggctcctag
4201 aagactccaa gggagtaaaa gagctgatga aacaatggca agacctccaa ggtgaaattg
4261 aagctcacac agatgtttat cacaacctgg atgaaaacag ccaaaaaatc ctgagatccc
4321 tggaaggttc cgatgatgca gtcctgttac aaagacgttt ggataacatg aacttcaagt
4381 ggagtgaact tcggaaaaag tctctcaaca ttaggtccca tttggaagcc agttctgacc
4441 agtggaagcg tctgcacctt tctctgcagg aacttctggt gtggctacag ctgaaagatg
4501 atgaattaag ccggcaggca cctattggag gcgactttcc agcagttcag aagcagaacg
4561 atgtacatag ggccttcaag agggaattga aaactaaaga acctgtaatc atgagtactc
4621 ttgagactgt acgaatattt ctgacagagc agcctttgga aggactagag aaactctacc
4681 aggagcccag agagctgcct cctgaggaga gagcccagaa tgtcactcgg cttctacgaa
4741 agcaggctga ggaggtcaat actgagtggg aaaaattgaa cctgcactcc gctgactggc
4801 agagaaaaat agatgagacc cttgaaagac tccaggaact tcaagaggcc acggatgagc
4861 tggacctcaa gctgcgccaa gctgaggtga tcaagggatc ctggcagccc gtgggcgatc
4921 tcctcattga ctctctccaa gatcacctcg agaaagtcaa ggcacttcga ggagaaattg
4981 cgcctctgaa agagaacgtg agccacgtca atgaccttgc tcgccagctt accactttgg
5041 gcattcagct ctcaccgtat aacctcagca ctctggaaga cctgaacacc agatggaagc
5101 ttctgcaggt ggccgtcgag gaccgagtca ggcagctgca tgaagcccac agggactttg
5161 gtccagcatc tcagcacttt ctttccacgt ctgtccaggg tccctgggag agagccatct
5221 cgccaaacaa agtgccctac tatatcaacc acgagactca aacaacttgc tgggaccatc
5281 ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga ttctcagctt
5341 ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat ctcttgagcc
5401 tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac cagcccatgg
5461 atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag caagagcaca
5521 acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg ctgaatgttt
5581 atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc atcatttccc
5641 tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg gcaagttcaa
5701 caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc caaattccaa
5761 gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt gtccggagct
5821 gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta gactggatga
5881 gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct gctgcagaaa
5941 ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt ggattcaggt
6001 acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt tctggtcgag
6061 ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg actacatcag
6121 gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc aaaaggtatt
6181 ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag ggggacaaca
6241 tggaaactcc cgttactctg atcaacttct ggccagtaga ttctgcgcct gcctcgtccc
6301 ctcagctttc acacgatgat actcattcac gcattgaaca ttatgctagc aggctagcag
6361 aaatggaaaa cagcaatgga tcttatctaa atgatagcat ctctcctaat gagagcatag
6421 atgatgaaca tttgttaatc cagcattact gccaaagttt gaaccaggac tcccccctga
6481 gccagcctcg tagtcctgcc cagatcttga tttccttaga gagtgaggaa agaggggagc
6541 tagagagaat cctagcagat cttgaggaag aaaacaggaa tctgcaagca gaatatgacc
6601 gtctaaagca gcagcacgaa cataaaggcc tgtccccact gccgtcccct cctgaaatga
6661 tgcccacctc tccccagagt ccccgggatg ctgagctcat tgctgaggcc aagctactgc
6721 gtcaacacaa aggccgcctg gaagccagga tgcaaatcct ggaagaccac aataaacagc
6781 tggagtcaca gttacacagg ctaaggcagc tgctggagca accccaggca gaggccaaag
6841 tgaatggcac aacggtgtcc tctccttcta cctctctaca gaggtccgac agcagtcagc
6901 ctatgctgct ccgagtggtt ggcagtcaaa cttcggactc catgggtgag gaagatcttc
6961 tcagtcctcc ccaggacaca agcacagggt tagaggaggt gatggagcaa ctcaacaact
7021 ccttccctag ttcaagagga agaaataccc ctggaaagcc aatgagagag gacacaatgt
7081 aggaagtctt ttccacatgg cagatgattt gggcagagcg atggagtcct tagtatcagt
7141 catgacagat gaagaaggag cagaataaat gttttacaac tcctgattcc cgcatggttt
7201 ttataatatt catacaacaa agaggattag acagtaagag tttacaagaa ataaatctat
7261 atttttgtga agggtagtgg tattatactg tagatttcag tagtttctaa gtctgttatt
7321 gttttgttaa caatggcagg ttttacacgt ctatgcaatt gtacaaaaaa gttataagaa
7381 aactacatgt aaaatcttga tagctaaata acttgccatt tctttatatg gaacgcattt
7441 tgggttgttt aaaaatttat aacagttata aagaaagatt gtaaactaaa gtgtgcttta
7501 taaaaaaaag ttgtttataa aaacccctaa aaacaaaaca aacacacaca cacacacata
7561 cacacacaca cacaaaactt tgaggcagcg cattgttttg catccttttg gcgtgatatc
7621 catatgaaat tcatggcttt ttcttttttt gcatattaaa gataagactt cctctaccac
7681 cacaccaaat gactactaca cactgctcat ttgagaactg tcagctgagt ggggcaggct
7741 tgagttttca tttcatatat ctatatgtct ataagtatat aaatactata gttatataga
7801 taaagagata cgaatttcta tagactgact ttttccattt tttaaatgtt catgtcacat
7861 cctaatagaa agaaattact tctagtcagt catccaggct tacctgcttg gtctagaatg
7921 gatttttccc ggagccggaa gccaggagga aactacacca cactaaaaca ttgtctacag
7981 ctccagatgt ttctcatttt aaacaacttt ccactgacaa cgaaagtaaa gtaaagtatt
8041 ggattttttt aaagggaaca tgtgaatgaa tacacaggac ttattatatc agagtgagta
8101 atcggttggt tggttgattg attgattgat tgatacattc agcttcctgc tgctagcaat
8161 gccacgattt agatttaatg atgcttcagt ggaaatcaat cagaaggtat tctgaccttg
8221 tgaacatcag aaggtatttt ttaactccca agcagtagca ggacgatgat agggctggag
8281 ggctatggat tcccagccca tccctgtgaa ggagtaggcc actctttaag tgaaggattg
8341 gatgattgtt cataatacat aaagttctct gtaattacaa ctaaattatt atgccctctt
8401 ctcacagtca aaaggaactg ggtggtttgg tttttgttgc ttttttagat ttattgtccc
8461 atgtgggatg agtttttaaa tgccacaaga cataatttaa aataaataaa ctttgggaaa
8521 aggtgtaaga cagtagcccc atcacatttg tgatactgac aggtatcaac ccagaagccc
8581 atgaactgtg tttccatcct ttgcatttct ctgcgagtag ttccacacag gtttgtaagt
8641 aagtaagaaa gaaggcaaat tgattcaaat gttacaaaaa aacccttctt ggtggattag
8701 acaggttaaa tatataaaca aacaaacaaa aattgctcaa aaaagaggag aaaagctcaa
8761 gaggaaaagc taaggactgg taggaaaaag ctttactctt tcatgccatt ttatttcttt
8821 ttgattttta aatcattcat tcaatagata ccaccgtgtg acctataatt ttgcaaatct
8881 gttacctctg acatcaagtg taattagctt ttggagagtg ggctgacatc aagtgtaatt
8941 agcttttgga gagtgggttt tgtccattat taataattaa ttaattaaca tcaaacacgg
9001 cttctcatgc tatttctacc tcactttggt tttggggtgt tcctgataat tgtgcacacc
9061 tgagttcaca gcttcaccac ttgtccattg cgttattttc tttttccttt ataattcttt
9121 ctttttcctt cataattttc aaaagaaaac ccaaagctct aaggtaacaa attaccaaat
9181 tacatgaaga tttggttttt gtcttgcatt tttttccttt atgtgacgct ggaccttttc
9241 tttacccaag gatttttaaa actcagattt aaaacaaggg gttactttac atcctactaa
9301 gaagtttaag taagtaagtt tcattctaaa atcagaggta aatagagtgc ataaataatt
9361 ttgttttaat ctttttgttt ttcttttaga cacattagct ctggagtgag tctgtcataa
9421 tatttgaaca aaaattgaga gctttattgc tgcattttaa gcataattaa tttggacatt
9481 atttcgtgtt gtgttcttta taaccaccga gtattaaact gtaaatcata atgtaactga
9541 agcataaaca tcacatggca tgttttgtca ttgttttcag gtactgagtt cttacttgag
9601 tatcataata tattgtgttt taacaccaac actgtaacat ttacgaatta tttttttaaa
9661 cttcagtttt actgcatttt cacaacatat cagacttcac caaatatatg ccttactatt
9721 gtattatagt actgctttac tgtgtatctc aataaagcac gcagttatgt tac
LOCUS Dp260-2 9916 bp mRNA PRI 20-JAN-1998
DEFINITION Human dystrophin cDNA isoform Dp260-2 (retina).
ACCESSION Dp260-2
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 239 to 9916)
AUTHORS D'Souza,V.N., Thi Man,N., Morris,G.E., Karges,W., Pillers,D.-A.M.
and Ray,P.N.
TITLE A novel dystrophin isoform is required for normal retinal
electrophysiology
JOURNAL Hum. Mol. Genet. 4, 837-842 (1995)
REFERENCE 2 (bases 1 to 238)
AUTHORS White,R.A.
TITLE Identification of cDNAs encoding two human retinal dystrophin
isoforms: alternative splicing of a complex novel first exon
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 9916)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
COMMENT Constructed consensus sequence of GenBank U27203 and M18533.
FEATURES Location/Qualifiers
source 1..9916
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp21.2"
5'UTR 1..199
CDS 200..7225
/codon_start=1
/product="Dystrophin Dp260-2"
/translation="MSARKLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTF
IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV
AQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH
CVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER
KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKE
IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ
KHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRD
QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLL
EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQ
LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER
KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRR
LNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK
DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ
WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK
WYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLS
DRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVE
ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEI
EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA
KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLT
TIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART
IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW
KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE
NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE
RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD
NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF
PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEER
AQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE
VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY
NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKV
PYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSA
ACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVY
DTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQI
PRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVA
AAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPV
DSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYC
QSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHK
GLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHR
LRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQ
DTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"
misc_feature 200..238
/note="Region: dystrophin Dp260-2 unique N-terminus"
misc_feature <239..5287
/note="Region: central rod domain"
misc_feature <239..268
/note="Region: repeat region 9"
misc_feature 269..556
/note="Region: repeat region 10"
misc_feature 548..871
/note="Region: repeat region 11"
misc_feature 872..1195
/note="Region: repeat region 12"
misc_feature 1196..1501
/note="Region: repeat region 13"
misc_feature 1502..1789
/note="Region: repeat region 14"
misc_feature 1790..2086
/note="Region: repeat region 15"
misc_feature 2141..2470
/note="Region: repeat region 16"
misc_feature 2471..2791
/note="Region: repeat region 17"
misc_feature 2792..3121
/note="Region: repeat region 18"
misc_feature 3122..3436
/note="Region: repeat region 19"
misc_feature 3437..3577
/note="Region: hinge region 3"
misc_feature 3578..3898
/note="Region: repeat region 20"
misc_feature 3899..4225
/note="Region: repeat region 21"
misc_feature 4226..4573
/note="Region: repeat region 22"
misc_feature 4574..4960
/note="Region: repeat region 23"
misc_feature 4961..5287
/note="Region: repeat region 24"
misc_feature 5207..5503
/note="Region: hinge region 4"
misc_feature 5333..5443
/note="Region: WW-domain"
misc_feature 5405..6391
/note="dystroglycan binding site"
misc_feature 5465..6067
/note="Region: Cysteine-rich domain"
misc_feature 5555..5638
/note="Region: EF-hand 1"
misc_feature 5699..5785
/note="Region: EF-hand 2"
misc_feature 6065..7222
/note="Region: Carboxy-terminal region"
misc_feature 6086..6229
/note="Region: ZZ-domain"
misc_feature 6497..6649
/note="alpha1-syntrophin binding site"
misc_feature 6650..6772
/note="beta1-syntrophin binding site"
misc_feature 6650..6772
/note="Region: beta1-syntrophin binding site"
misc_feature 6839..6946
/note="Region: (Leu)6-heptad repeat"
3'UTR 7226..9916
polyA_signal 9894..9899
polyA_site 9916
BASE COUNT 3199 a 1975 c 2202 g 2540 t
ORIGIN
1 ......gaga tcaggaggaa cattcgacct gagaaagaca gattgcaatg actgagatta
61 ttttgctaat tttttttcca gcctatttcc ttaatgtacg tgatattgtg attgattttc
121 atgcagagat ccctgatcct atagttttgt ttgctattta tttttctcct tcacattttt
181 tttctatcaa cagagctgaa tgagtgccag gaagctgcga aatctgtctt acaaaaaggc
241 tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga ctgaaaaatc
301 cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag cttatattgc
361 agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat ctgatttgac
421 aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg aggctgccca
481 aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct ccatgaagtt
541 tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta agatgatttt
601 agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac aggaagtagt
661 acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag tgaagtctga
721 agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga cggaaaatcc
781 caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc tgggagcaaa
841 ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta agatgcgaaa
901 ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga caaagagatc
961 agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa aggctactca
1021 aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag gagaggcctt
1081 gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc ttctgaatag
1141 taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt tggaatacca
1201 gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga tcattcaggc
1261 tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag acgtgcttaa
1321 gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac gtgaccaagc
1381 agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc cccaaatctc
1441 agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa aggcctccat
1501 tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg aaccactgga
1561 ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag atatgaatga
1621 agacaatgag ggtactgtaa aagaattgtt gcaaagagga gacaacttac aacaaagaat
1681 cacagatgag agaaagcgag aggaaataaa gataaaacag cagctgttac agacaaaaca
1741 taatgctctc aaggatttga ggtctcaaag aagaaaaaag gctctagaaa tttctcatca
1801 gtggtatcag tacaagaggc aggctgatga tctcctgaaa tgcttggatg acattgaaaa
1861 aaaattagcc agcctacctg agcccagaga tgaaaggaaa ataaaggaaa ttgatcggga
1921 attgcagaag aagaaagagg agctgaatgc agtgcgtagg caagctgagg gcttgtctga
1981 ggatggggcc gcaatggcag tggagccaac tcagatccag ctcagcaagc gctggcggga
2041 aattgagagc aaatttgctc agtttcgaag actcaacttt gcacaaattc acactgtccg
2101 tgaagaaacg atgatggtga tgactgaaga catgcctttg gaaatttctt atgtgccttc
2161 tacttatttg actgaaatca ctcatgtctc acaagcccta ttagaagtgg aacaacttct
2221 caatgctcct gacctctgtg ctaaggactt tgaagatctc tttaagcaag aggagtctct
2281 gaagaatata aaagatagtc tacaacaaag ctcaggtcgg attgacatta ttcatagcaa
2341 gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg gtgaagctac aggaagctct
2401 ctcccagctt gatttccaat gggaaaaagt taacaaaatg tacaaggacc gacaagggcg
2461 atttgacaga tctgttgaga aatggcggcg ttttcattat gatataaaga tatttaatca
2521 gtggctaaca gaagctgaac agtttctcag aaagacacaa attcctgaga attgggaaca
2581 tgctaaatac aaatggtatc ttaaggaact ccaggatggc attgggcagc ggcaaactgt
2641 tgtcagaaca ttgaatgcaa ctggggaaga aataattcag caatcctcaa aaacagatgc
2701 cagtattcta caggaaaaat tgggaagcct gaatctgcgg tggcaggagg tctgcaaaca
2761 gctgtcagac agaaaaaaga ggctagaaga acaaaagaat atcttgtcag aatttcaaag
2821 agatttaaat gaatttgttt tatggttgga ggaagcagat aacattgcta gtatcccact
2881 tgaacctgga aaagagcagc aactaaaaga aaagcttgag caagtcaagt tactggtgga
2941 agagttgccc ctgcgccagg gaattctcaa acaattaaat gaaactggag gacccgtgct
3001 tgtaagtgct cccataagcc cagaagagca agataaactt gaaaataagc tcaagcagac
3061 aaatctccag tggataaagg tttccagagc tttacctgag aaacaaggag aaattgaagc
3121 tcaaataaaa gaccttgggc agcttgaaaa aaagcttgaa gaccttgaag agcagttaaa
3181 tcatctgctg ctgtggttat ctcctattag gaatcagttg gaaatttata accaaccaaa
3241 ccaagaagga ccatttgacg ttcaggaaac tgaaatagca gttcaagcta aacaaccgga
3301 tgtggaagag attttgtcta aagggcagca tttgtacaag gaaaaaccag ccactcagcc
3361 agtgaagagg aagttagaag atctgagctc tgagtggaag gcggtaaacc gtttacttca
3421 agagctgagg gcaaagcagc ctgacctagc tcctggactg accactattg gagcctctcc
3481 tactcagact gttactctgg tgacacaacc tgtggttact aaggaaactg ccatctccaa
3541 actagaaatg ccatcttcct tgatgttgga ggtacctgct ctggcagatt tcaaccgggc
3601 ttggacagaa cttaccgact ggctttctct gcttgatcaa gttataaaat cacagagggt
3661 gatggtgggt gaccttgagg atatcaacga gatgatcatc aagcagaagg caacaatgca
3721 ggatttggaa cagaggcgtc cccagttgga agaactcatt accgctgccc aaaatttgaa
3781 aaacaagacc agcaatcaag aggctagaac aatcattacg gatcgaattg aaagaattca
3841 gaatcagtgg gatgaagtac aagaacacct tcagaaccgg aggcaacagt tgaatgaaat
3901 gttaaaggat tcaacacaat ggctggaagc taaggaagaa gctgagcagg tcttaggaca
3961 ggccagagcc aagcttgagt catggaagga gggtccctat acagtagatg caatccaaaa
4021 gaaaatcaca gaaaccaagc agttggccaa agacctccgc cagtggcaga caaatgtaga
4081 tgtggcaaat gacttggccc tgaaacttct ccgggattat tctgcagatg ataccagaaa
4141 agtccacatg ataacagaga atatcaatgc ctcttggaga agcattcata aaagggtgag
4201 tgagcgagag gctgctttgg aagaaactca tagattactg caacagttcc ccctggacct
4261 ggaaaagttt cttgcctggc ttacagaagc tgaaacaact gccaatgtcc tacaggatgc
4321 tacccgtaag gaaaggctcc tagaagactc caagggagta aaagagctga tgaaacaatg
4381 gcaagacctc caaggtgaaa ttgaagctca cacagatgtt tatcacaacc tggatgaaaa
4441 cagccaaaaa atcctgagat ccctggaagg ttccgatgat gcagtcctgt tacaaagacg
4501 tttggataac atgaacttca agtggagtga acttcggaaa aagtctctca acattaggtc
4561 ccatttggaa gccagttctg accagtggaa gcgtctgcac ctttctctgc aggaacttct
4621 ggtgtggcta cagctgaaag atgatgaatt aagccggcag gcacctattg gaggcgactt
4681 tccagcagtt cagaagcaga acgatgtaca tagggccttc aagagggaat tgaaaactaa
4741 agaacctgta atcatgagta ctcttgagac tgtacgaata tttctgacag agcagccttt
4801 ggaaggacta gagaaactct accaggagcc cagagagctg cctcctgagg agagagccca
4861 gaatgtcact cggcttctac gaaagcaggc tgaggaggtc aatactgagt gggaaaaatt
4921 gaacctgcac tccgctgact ggcagagaaa aatagatgag acccttgaaa gactccagga
4981 acttcaagag gccacggatg agctggacct caagctgcgc caagctgagg tgatcaaggg
5041 atcctggcag cccgtgggcg atctcctcat tgactctctc caagatcacc tcgagaaagt
5101 caaggcactt cgaggagaaa ttgcgcctct gaaagagaac gtgagccacg tcaatgacct
5161 tgctcgccag cttaccactt tgggcattca gctctcaccg tataacctca gcactctgga
5221 agacctgaac accagatgga agcttctgca ggtggccgtc gaggaccgag tcaggcagct
5281 gcatgaagcc cacagggact ttggtccagc atctcagcac tttctttcca cgtctgtcca
5341 gggtccctgg gagagagcca tctcgccaaa caaagtgccc tactatatca accacgagac
5401 tcaaacaact tgctgggacc atcccaaaat gacagagctc taccagtctt tagctgacct
5461 gaataatgtc agattctcag cttataggac tgccatgaaa ctccgaagac tgcagaaggc
5521 cctttgcttg gatctcttga gcctgtcagc tgcatgtgat gccttggacc agcacaacct
5581 caagcaaaat gaccagccca tggatatcct gcagattatt aattgtttga ccactattta
5641 tgaccgcctg gagcaagagc acaacaattt ggtcaacgtc cctctctgcg tggatatgtg
5701 tctgaactgg ctgctgaatg tttatgatac gggacgaaca gggaggatcc gtgtcctgtc
5761 ttttaaaact ggcatcattt ccctgtgtaa agcacatttg gaagacaagt acagatacct
5821 tttcaagcaa gtggcaagtt caacaggatt ttgtgaccag cgcaggctgg gcctccttct
5881 gcatgattct atccaaattc caagacagtt gggtgaagtt gcatcctttg ggggcagtaa
5941 cattgagcca agtgtccgga gctgcttcca atttgctaat aataagccag agatcgaagc
6001 ggccctcttc ctagactgga tgagactgga accccagtcc atggtgtggc tgcccgtcct
6061 gcacagagtg gctgctgcag aaactgccaa gcatcaggcc aaatgtaaca tctgcaaaga
6121 gtgtccaatc attggattca ggtacaggag tctaaagcac tttaattatg acatctgcca
6181 aagctgcttt ttttctggtc gagttgcaaa aggccataaa atgcactatc ccatggtgga
6241 atattgcact ccgactacat caggagaaga tgttcgagac tttgccaagg tactaaaaaa
6301 caaatttcga accaaaaggt attttgcgaa gcatccccga atgggctacc tgccagtgca
6361 gactgtctta gagggggaca acatggaaac tcccgttact ctgatcaact tctggccagt
6421 agattctgcg cctgcctcgt cccctcagct ttcacacgat gatactcatt cacgcattga
6481 acattatgct agcaggctag cagaaatgga aaacagcaat ggatcttatc taaatgatag
6541 catctctcct aatgagagca tagatgatga acatttgtta atccagcatt actgccaaag
6601 tttgaaccag gactcccccc tgagccagcc tcgtagtcct gcccagatct tgatttcctt
6661 agagagtgag gaaagagggg agctagagag aatcctagca gatcttgagg aagaaaacag
6721 gaatctgcaa gcagaatatg accgtctaaa gcagcagcac gaacataaag gcctgtcccc
6781 actgccgtcc cctcctgaaa tgatgcccac ctctccccag agtccccggg atgctgagct
6841 cattgctgag gccaagctac tgcgtcaaca caaaggccgc ctggaagcca ggatgcaaat
6901 cctggaagac cacaataaac agctggagtc acagttacac aggctaaggc agctgctgga
6961 gcaaccccag gcagaggcca aagtgaatgg cacaacggtg tcctctcctt ctacctctct
7021 acagaggtcc gacagcagtc agcctatgct gctccgagtg gttggcagtc aaacttcgga
7081 ctccatgggt gaggaagatc ttctcagtcc tccccaggac acaagcacag ggttagagga
7141 ggtgatggag caactcaaca actccttccc tagttcaaga ggaagaaata cccctggaaa
7201 gccaatgaga gaggacacaa tgtaggaagt cttttccaca tggcagatga tttgggcaga
7261 gcgatggagt ccttagtatc agtcatgaca gatgaagaag gagcagaata aatgttttac
7321 aactcctgat tcccgcatgg tttttataat attcatacaa caaagaggat tagacagtaa
7381 gagtttacaa gaaataaatc tatatttttg tgaagggtag tggtattata ctgtagattt
7441 cagtagtttc taagtctgtt attgttttgt taacaatggc aggttttaca cgtctatgca
7501 attgtacaaa aaagttataa gaaaactaca tgtaaaatct tgatagctaa ataacttgcc
7561 atttctttat atggaacgca ttttgggttg tttaaaaatt tataacagtt ataaagaaag
7621 attgtaaact aaagtgtgct ttataaaaaa aagttgttta taaaaacccc taaaaacaaa
7681 acaaacacac acacacacac atacacacac acacacaaaa ctttgaggca gcgcattgtt
7741 ttgcatcctt ttggcgtgat atccatatga aattcatggc tttttctttt tttgcatatt
7801 aaagataaga cttcctctac caccacacca aatgactact acacactgct catttgagaa
7861 ctgtcagctg agtggggcag gcttgagttt tcatttcata tatctatatg tctataagta
7921 tataaatact atagttatat agataaagag atacgaattt ctatagactg actttttcca
7981 ttttttaaat gttcatgtca catcctaata gaaagaaatt acttctagtc agtcatccag
8041 gcttacctgc ttggtctaga atggattttt cccggagccg gaagccagga ggaaactaca
8101 ccacactaaa acattgtcta cagctccaga tgtttctcat tttaaacaac tttccactga
8161 caacgaaagt aaagtaaagt attggatttt tttaaaggga acatgtgaat gaatacacag
8221 gacttattat atcagagtga gtaatcggtt ggttggttga ttgattgatt gattgataca
8281 ttcagcttcc tgctgctagc aatgccacga tttagattta atgatgcttc agtggaaatc
8341 aatcagaagg tattctgacc ttgtgaacat cagaaggtat tttttaactc ccaagcagta
8401 gcaggacgat gatagggctg gagggctatg gattcccagc ccatccctgt gaaggagtag
8461 gccactcttt aagtgaagga ttggatgatt gttcataata cataaagttc tctgtaatta
8521 caactaaatt attatgccct cttctcacag tcaaaaggaa ctgggtggtt tggtttttgt
8581 tgctttttta gatttattgt cccatgtggg atgagttttt aaatgccaca agacataatt
8641 taaaataaat aaactttggg aaaaggtgta agacagtagc cccatcacat ttgtgatact
8701 gacaggtatc aacccagaag cccatgaact gtgtttccat cctttgcatt tctctgcgag
8761 tagttccaca caggtttgta agtaagtaag aaagaaggca aattgattca aatgttacaa
8821 aaaaaccctt cttggtggat tagacaggtt aaatatataa acaaacaaac aaaaattgct
8881 caaaaaagag gagaaaagct caagaggaaa agctaaggac tggtaggaaa aagctttact
8941 ctttcatgcc attttatttc tttttgattt ttaaatcatt cattcaatag ataccaccgt
9001 gtgacctata attttgcaaa tctgttacct ctgacatcaa gtgtaattag cttttggaga
9061 gtgggctgac atcaagtgta attagctttt ggagagtggg ttttgtccat tattaataat
9121 taattaatta acatcaaaca cggcttctca tgctatttct acctcacttt ggttttgggg
9181 tgttcctgat aattgtgcac acctgagttc acagcttcac cacttgtcca ttgcgttatt
9241 ttctttttcc tttataattc tttctttttc cttcataatt ttcaaaagaa aacccaaagc
9301 tctaaggtaa caaattacca aattacatga agatttggtt tttgtcttgc atttttttcc
9361 tttatgtgac gctggacctt ttctttaccc aaggattttt aaaactcaga tttaaaacaa
9421 ggggttactt tacatcctac taagaagttt aagtaagtaa gtttcattct aaaatcagag
9481 gtaaatagag tgcataaata attttgtttt aatctttttg tttttctttt agacacatta
9541 gctctggagt gagtctgtca taatatttga acaaaaattg agagctttat tgctgcattt
9601 taagcataat taatttggac attatttcgt gttgtgttct ttataaccac cgagtattaa
9661 actgtaaatc ataatgtaac tgaagcataa acatcacatg gcatgttttg tcattgtttt
9721 caggtactga gttcttactt gagtatcata atatattgtg ttttaacacc aacactgtaa
9781 catttacgaa ttattttttt aaacttcagt tttactgcat tttcacaaca tatcagactt
9841 caccaaatat atgccttact attgtattat agtactgctt tactgtgtat ctcaataaag
9901 cacgcagtta tgttac
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