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Zebra fish DMD sequences

(last modified on October 29, 2001)

Content

• consensus 3' DMD cDNA sequence
• consensus C-terminal DMD Dp427 protein sequence

3' DMD cDNA

Consensus sequence derived from AF339031 and several zebra fish EST's, a.o. BE557463, BE605910, BG738484; compared to AF339031 it does contain exon 73 (bold italics) and 6 additional nucleotides between exon 75 and 76 (underlined italics).

CCGTTTCTGTCGACATTGGGAAGATTCTCATGCCAAGCTGACGGCCAGAGTTCTTACACTGCAGAACATG
TATAAGGACTCCAGCGATTGGTTGGAGGCCAGAAAAAGGGTGGAGCCTCTCATTAAGAAAGCCAATGAAA
AACTCGAGAGCTGGAAGAAAGTTTCGCACAGCGTTGAAGATTTAAAAGGCCAAAATGCAGATGTCAAGCA
ACTTTCTAAGGATCTACAGCAGTGGCAGACTCAGATGAATGTCACTAATGAGCTGGCAAACAAACTACTG
ACTCTTTATGCAGACGACGACACAAGCAAAGTGAAACAAATGACCGAGAGCATGAATCTGGCTTGGGCCA
ACATCAAAAAGCGTGCAGGGGACAAGGAGGCAGATCTGGAAGCTGGACTTCGGCAGTTGCAGCATTACTA
CTTGGACCTGGAGAAATTCCTTAATTGGCTAACGGAGGCAGAAACCACAGCCAATGTCTTACAAGATGCC
ACCTTTAAGGAGGGACTTCTGGAAAATCCTGCCACAGTTCGACATTTACTCGAGCAATGGCAGGATCTCC
AGGCAGAGATTGATGCTCACCGGGAGACGTACCATTCATTAGATGAAAACGGACATCGTATTGTGTCGTC
TCTGGAGGGAACGGACAATGCTGTGGTGCTACAAAAACGGCTTGATGACATGGGGCAGCGCTGGCATGAG
TTGTGCAACAAAGTTATGAGTATAAGGCCCTATCTAGATGCCGGCGTTGATCAGTGGAAACACTTGCACA
TGTCCTTACAAGAGCTGCTCAACTGGCTGCAGCTGAAGAGGGAAGAGCTGGAGAAGCAGAAGCCAGTAGG
GGGCGACGTGCCGACCGTTCACCAACAACTCCTCACGCACAAGGCTTTCAGAAGAGAGCTGGGTGCCAAA
GAACCTGTAATCAATGGAACTCTCGACAATGCGAAAACCTTCCTTGCTGAGATGCCTCGTGAGGGCCTGA
AACAGAGACCTGGACAAAAAGATGTAAGTCCTGAGGAGCGGGTTCAAAACGTGGGCCGCATATTGCGTAA
AGAAGTGGAGGATGTAACGGTGCGATGGAAGAATCTGGGTGCAGCTTCTGTGGACTGGCAGCAACAGCTG
GAACTGGCCTTGGAGAGGCTGATGGAGCTCCAGGACGCCCAGGATCAGCTGGACTACAAGCTACGACAGG
CTGAGAGCGTGAAGAATTCTTGGAAGCCTGTTGGGGAGCTGCTTGTAGACGATTTGCAAAACCACATAGA
CAGAGTGAAGGCATTTCAGGAAGAGATAGCTCCCATTCAGGATAACGTAAATCATGTTAACCAGCTGGCC
TCCACATTTAGACCGTCTGACATTCAGCTTTCTCCAGACAACCTGAGCAGAATCGATGACCTCAACATGA
GATGGAGGCTTCTGCAGATCTCCATTGAGGAGCATCTGAGTCAGCTGACCACAGCCTTTAAGGACTTGGG
ACCCTCTCAGAATTTCCTTCATGCGTCTGTTGAAAGCCCTCTCGAACGCTCTATTTCACCCAACAATGTC
CCCTACTATATCAATCACCAGACCCAAACAACATGTTGGGACCACCCAAAGATGGCAGAACTCTACCAGT
CATTAGCGGATCTCAACAACGTGCGGTTCTCGGCATACAGGACGGCAATGAAGCTCAGACGAATGCAGAA
AGCCCTCTGTTTGGATCTTCTGAGCATGCCTGCAGCCTGTGAAGCCTTTGAGCAGCACAATCTCAAACAG
AACGAGCAGTTCATGGACATCGTGCAGGTGATCAACTGTCTGACCAGCATCTACGACCGTCTGGAGCAGC
AGCACAGCAGCCTGGTCAACGTGCCTCTCTGTGTGGACATGTGTCTCAACTGGCTGCTCAACGTTTACGA
TACAGGACGAGCTGGGAAGATTCGTACCCTATCCTTCAAAACAGGAATAATCTCTTTGTGCAAAGCTCAC
CTTGAAGATAAGTACAGATTTTTATTTCGAGAGGTGGCCAGTGCCACAGGCTTCTGTGACCAGCGGCGCC
TCGGCCTCCTCCTGCATGATGCCATTCAGATCCCCAGGCAGCTGGGTGAAGTGGCGTCTTTCGGAGGGAG
CAATATTGAGCCCAGTGTGCGCAGCTGCTTTCAGTTCGCCAATAACAAACCGGAGTTAGAGGCTTCAGTC
TTCCTGGACTGGATGCGTTTAGAACCTCAGTCGATGGTTTGGCTTCCTGTCCTTCACCGTGTAGCGGCCG
CTGAGACAGCAAAGCACCAGGCTAAATGCAACATTTGTAAGGAATGTCCTATTATTGGCTTCAGGTACCG
AAGTTTAAAGCACTTTAACTATGATATCTGCCAAAGCTGCTTCTTTTCTGGCAGAGTGGCCAAAGGTCAC
AAGATGCAGTACCCTATGGTTGAATATTGCACACCGACGACGTCAGGAGAGGATGTGAGAGACTTTGCCA
AGGTGTTAAAGAACAAGTTCAGGACAAAGCGCTATTTTGCCAAGCACCCTCGCATGGGTTACCTTCCCGT
CCAGACCATCCTTGAAGGAGACAACATGGAGACTCCTGTTACACTGATCAACTTCTGGCCTGTTGACCAT
CCGCCTGCATCTTCCCCTCAACTCTCCCATGACGACACCCACTCTCGCATCGAGCATTACGCTAGCAGgc
tagctgaaatggagaaccgaaatggctcgtatgtgaatgacaatgtatcgcccaatgaaagcatGGATGA
TGAGCATCTGCTGATCCAGCACTACTGCCAGAGTCTGAATCAAGGCTCTCCTCTCAGCCAGCCGCAGAGC
CCCGCTCAGATCCTCATCTCAATGGAGACTGAAGAGAAGGGAGAGCTGGAGAGAGTGCTCAATGATCTGG
AGCAGGAAAACAGGAAGCTGCAAGCGGAGTACGATCGTCTGAAAAAGGCACACGATCACAAGGGTCTGTC
ACCGTTGCCTTCACCTCCACAGATGCTTCCGGTGTCGCCTCAAAGTCCACGCGACGCAGAACTAATCGCA
GAAGCCAAACTACTGCGGCAACACAAGGGACGATTGGAGGCAAGAATGCAAATCCTGGAGGATCACAACA
AGCAGCTGGAATCGCAGCTTACACGCCTAAGACAGTTACTCGAGCAGccacagACTGAGTCCAAGGTGAA
TGGCACTGCCCTGTCCTCACCCTCCACTGCCTCTCCGAGATCTGACACCAGCCTGGCCTCACTGCGTGTG
GCCGCAAGCCAAACCACAGAGACCATGGGTGATGATGAGCTGTCCAGTCCCACCCAGGATGCAAGCACTG
GATTAGAAGACGTCATCGAGCAGCTCAACAACTCCTTCCCTCACAGCCAAGGAGGCGGACGGCTAAATCC
ATGAGAGGTCCCAATGTGGGAAGTCTTTTCCACATGGTTGATAACATTGGACATGCCATGGAGTCGCTGG
TTCATGTAATAACAGAGGAGCAGGATTTAGACTGAAGACGTCTTCTCCTCGTTGCATGCTTTTGTAGTGT
CAACAACTGGACCGGATATGTTTACAATGGGGAATATCAATAAAAATCTATTTTTCTGAAGGAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAA

C-terminal DMD Dp427 protein sequence

Consensus protein sequence derived from the above cDNA sequence

RFCRHWEDSHAKLTARVLTLQNMYKDSSDWLEARKRVEPLIKKANEKLESWKKVSHSVEDLKGQNADVKQ
LSKDLQQWQTQMNVTNELANKLLTLYADDDTSKVKQMTESMNLAWANIKKRAGDKEADLEAGLRQLQHYY
LDLEKFLNWLTEAETTANVLQDATFKEGLLENPATVRHLLEQWQDLQAEIDAHRETYHSLDENGHRIVSS
LEGTDNAVVLQKRLDDMGQRWHELCNKVMSIRPYLDAGVDQWKHLHMSLQELLNWLQLKREELEKQKPVG
GDVPTVHQQLLTHKAFRRELGAKEPVINGTLDNAKTFLAEMPREGLKQRPGQKDVSPEERVQNVGRILRK
EVEDVTVRWKNLGAASVDWQQQLELALERLMELQDAQDQLDYKLRQAESVKNSWKPVGELLVDDLQNHID
RVKAFQEEIAPIQDNVNHVNQLASTFRPSDIQLSPDNLSRIDDLNMRWRLLQISIEEHLSQLTTAFKDLG
PSQNFLHASVESPLERSISPNNVPYYINHQTQTTCWDHPKMAELYQSLADLNNVRFSAYRTAMKLRRMQK
ALCLDLLSMPAACEAFEQHNLKQNEQFMDIVQVINCLTSIYDRLEQQHSSLVNVPLCVDMCLNWLLNVYD
TGRAGKIRTLSFKTGIISLCKAHLEDKYRFLFREVASATGFCDQRRLGLLLHDAIQIPRQLGEVASFGGS
NIEPSVRSCFQFANNKPELEASVFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYR
SLKHFNYDICQSCFFSGRVAKGHKMQYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV
QTILEGDNMETPVTLINFWPVDHPPASSPQLSHDDTHSRIEHYASRLAEMENRNGSYVNDNVSPNESMDD
EHLLIQHYCQSLNQGSPLSQPQSPAQILISMETEEKGELERVLNDLEQENRKLQAEYDRLKKAHDHKGLS
PLPSPPQMLPVSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLTRLRQLLEQPQTESKVN
GTALSSPSTASPRSDTSLASLRVAASQTTETMGDDELSSPTQDASTGLEDVIEQLNNSFPHSQGGGRLNP
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