Agrin (AGRN) - coding DNA reference sequence

(used for mutation description)

(last modified January 16, 2010)


This file was created to facilitate the description of sequence variants in the AGRN gene based on a coding DNA reference sequence following the HGVS recommendations. The sequence was taken from NG_016346.1, covering AGRN transcript NM_198576.2.

Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           cccgtccccggcgcggcccgcgcgctcctccgccgcctctcgcctgcgcc       c.-1

          .         .         .         .         .         .       g.5110
 ATGGCCGGCCGGTCCCACCCGGGCCCGCTGCGGCCGCTGCTGCCGCTCCTTGTGGTGGCC       c.60
 M  A  G  R  S  H  P  G  P  L  R  P  L  L  P  L  L  V  V  A         p.20

          .         .         .         .         .         .       g.5170
 GCGTGCGTCCTGCCCGGAGCCGGCGGGACATGCCCGGAGCGCGCGCTGGAGCGGCGCGAG       c.120
 A  C  V  L  P  G  A  G  G  T  C  P  E  R  A  L  E  R  R  E         p.40

          .         .         .         .         .         .       g.5230
 GAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAGGAGATCCTCAACGTGGACCCGGTG       c.180
 E  E  A  N  V  V  L  T  G  T  V  E  E  I  L  N  V  D  P  V         p.60

          .         .  | 02      .         .         .         .    g.7117
 CAGCACACGTACTCCTGCAAG | GTTCGGGTCTGGCGGTACTTGAAGGGCAAAGACCTGGTG    c.240
 Q  H  T  Y  S  C  K   | V  R  V  W  R  Y  L  K  G  K  D  L  V      p.80

          .         .         .         .         .         .       g.7177
 GCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTGGAGACCCC       c.300
 A  R  E  S  L  L  D  G  G  N  K  V  V  I  S  G  F  G  D  P         p.100

          .         .         .         .         .         .       g.7237
 CTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCA       c.360
 L  I  C  D  N  Q  V  S  T  G  D  T  R  I  F  F  V  N  P  A         p.120

          .         .         .         .         .         .       g.7297
 CCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGG       c.420
 P  P  Y  L  W  P  A  H  K  N  E  L  M  L  N  S  S  L  M  R         p.140

          .         .         .         .    | 03    .         .    g.20171
 ATCACCCTGCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAG | ATAAACCCGGGACCCAC    c.480
 I  T  L  R  N  L  E  E  V  E  F  C  V  E  D |   K  P  G  T  H      p.160

          .         .         .  | 04      .         .         .    g.25571
 TTCACTCCAGTGCCTCCGACGCCTCCTGATG | CGTGCCGGGGAATGCTGTGCGGCTTCGGC    c.540
 F  T  P  V  P  P  T  P  P  D  A |   C  R  G  M  L  C  G  F  G      p.180

          .         .         .         .         .         .       g.25631
 GCCGTGTGCGAGCCCAACGCGGAGGGGCCGGGCCGGGCGTCCTGCGTCTGCAAGAAGAGC       c.600
 A  V  C  E  P  N  A  E  G  P  G  R  A  S  C  V  C  K  K  S         p.200

          .         .         .         .         .         .       g.25691
 CCGTGCCCCAGCGTGGTGGCGCCTGTGTGTGGGTCGGACGCCTCCACCTACAGCAACGAA       c.660
 P  C  P  S  V  V  A  P  V  C  G  S  D  A  S  T  Y  S  N  E         p.220

          .         .         .         .         .         .       g.25751
 TGCGAGCTGCAGCGGGCGCAGTGCAGCCAGCAGCGCCGCATCCGCCTGCTCAGCCGCGGG       c.720
 C  E  L  Q  R  A  Q  C  S  Q  Q  R  R  I  R  L  L  S  R  G         p.240

         | 05.         .         .         .         .         .    g.26103
 CCGTGCG | GCTCGCGGGACCCCTGCTCCAACGTGACCTGCAGCTTCGGCAGCACCTGTGCG    c.780
 P  C  G |   S  R  D  P  C  S  N  V  T  C  S  F  G  S  T  C  A      p.260

          .         .         .         .         .         .       g.26163
 CGCTCGGCCGACGGGCTGACGGCCTCGTGCCTGTGCCCCGCGACCTGCCGTGGCGCCCCC       c.840
 R  S  A  D  G  L  T  A  S  C  L  C  P  A  T  C  R  G  A  P         p.280

          .         .         .         .         .         .       g.26223
 GAGGGGACCGTCTGCGGCAGCGACGGCGCCGACTACCCCGGCGAGTGCCAGCTCCTGCGC       c.900
 E  G  T  V  C  G  S  D  G  A  D  Y  P  G  E  C  Q  L  L  R         p.300

          .         .         .         .         .   | 06     .    g.26363
 CGCGCCTGCGCCCGCCAGGAGAATGTCTTCAAGAAGTTCGACGGCCCTTGTG | ACCCCTGT    c.960
 R  A  C  A  R  Q  E  N  V  F  K  K  F  D  G  P  C  D |   P  C      p.320

          .         .         .         .         .         .       g.26423
 CAGGGCGCCCTCCCTGACCCGAGCCGCAGCTGCCGTGTGAACCCGCGCACGCGGCGCCCT       c.1020
 Q  G  A  L  P  D  P  S  R  S  C  R  V  N  P  R  T  R  R  P         p.340

          .         .         .         .         .         .       g.26483
 GAGATGCTCCTACGGCCCGAGAGCTGCCCTGCCCGGCAGGCGCCAGTGTGTGGGGACGAC       c.1080
 E  M  L  L  R  P  E  S  C  P  A  R  Q  A  P  V  C  G  D  D         p.360

          .         .         .         .         .         .       g.26543
 GGAGTCACCTACGAAAACGACTGTGTCATGGGCCGATCGGGGGCCGCCCGGGGTCTCCTC       c.1140
 G  V  T  Y  E  N  D  C  V  M  G  R  S  G  A  A  R  G  L  L         p.380

          .         .         .        | 07.         .         .    g.26856
 CTGCAGAAAGTGCGCTCCGGCCAGTGCCAGGGTCGAG | ACCAGTGCCCGGAGCCCTGCCGG    c.1200
 L  Q  K  V  R  S  G  Q  C  Q  G  R  D |   Q  C  P  E  P  C  R      p.400

          .         .         .         .         .         .       g.26916
 TTCAATGCCGTGTGCCTGTCCCGCCGTGGCCGTCCCCGCTGCTCCTGCGACCGCGTCACC       c.1260
 F  N  A  V  C  L  S  R  R  G  R  P  R  C  S  C  D  R  V  T         p.420

          .         .         .         .         .         .       g.26976
 TGTGACGGGGCCTACAGGCCCGTGTGTGCCCAGGACGGGCGCACGTATGACAGTGATTGC       c.1320
 C  D  G  A  Y  R  P  V  C  A  Q  D  G  R  T  Y  D  S  D  C         p.440

          .         .         .         .         .         .       g.27036
 TGGCGGCAGCAGGCTGAGTGCCGGCAGCAGCGTGCCATCCCCAGCAAGCACCAGGGCCCG       c.1380
 W  R  Q  Q  A  E  C  R  Q  Q  R  A  I  P  S  K  H  Q  G  P         p.460

      | 08   .         .         .         .         .         .    g.28172
 TGTG | ACCAGGCCCCGTCCCCATGCCTCGGGGTGCAGTGTGCATTTGGGGCGACGTGTGCT    c.1440
 C  D |   Q  A  P  S  P  C  L  G  V  Q  C  A  F  G  A  T  C  A      p.480

          .         .         .         .         .         .       g.28232
 GTGAAGAACGGGCAGGCAGCGTGTGAATGCCTGCAGGCGTGCTCGAGCCTCTACGATCCT       c.1500
 V  K  N  G  Q  A  A  C  E  C  L  Q  A  C  S  S  L  Y  D  P         p.500

          .         .         .         .         .         .       g.28292
 GTGTGCGGCAGCGACGGCGTCACATACGGCAGCGCGTGCGAGCTGGAGGCCACGGCCTGT       c.1560
 V  C  G  S  D  G  V  T  Y  G  S  A  C  E  L  E  A  T  A  C         p.520

          .         .         .         .    | 09    .         .    g.28432
 ACCCTCGGGCGGGAGATCCAGGTGGCGCGCAAAGGACCCTGTG | ACCGCTGCGGGCAGTGC    c.1620
 T  L  G  R  E  I  Q  V  A  R  K  G  P  C  D |   R  C  G  Q  C      p.540

          .         .         .         .         .         .       g.28492
 CGCTTTGGAGCCCTGTGCGAGGCCGAGACCGGGCGCTGCGTGTGCCCCTCTGAATGCGTG       c.1680
 R  F  G  A  L  C  E  A  E  T  G  R  C  V  C  P  S  E  C  V         p.560

          .         .         .         .         .         .       g.28552
 GCTTTGGCCCAGCCCGTGTGTGGCTCCGACGGGCACACGTACCCCAGCGAGTGCATGCTG       c.1740
 A  L  A  Q  P  V  C  G  S  D  G  H  T  Y  P  S  E  C  M  L         p.580

          .         .         .         .         .         | 10    g.28702
 CACGTGCACGCCTGCACACACCAGATCAGCCTGCACGTGGCCTCAGCTGGACCCTGTG | AG    c.1800
 H  V  H  A  C  T  H  Q  I  S  L  H  V  A  S  A  G  P  C  E |       p.600

          .         .         .         .         .         .       g.28762
 ACCTGTGGAGATGCCGTGTGTGCTTTTGGGGCTGTGTGCTCCGCAGGGCAGTGTGTGTGT       c.1860
 T  C  G  D  A  V  C  A  F  G  A  V  C  S  A  G  Q  C  V  C         p.620

          .         .         .         .         .         .       g.28822
 CCCCGGTGTGAGCACCCCCCGCCCGGCCCCGTGTGTGGCAGCGACGGTGTCACCTACGGC       c.1920
 P  R  C  E  H  P  P  P  G  P  V  C  G  S  D  G  V  T  Y  G         p.640

          .         .         .         .         .         .       g.28882
 AGTGCCTGCGAGCTACGGGAAGCCGCCTGCCTCCAGCAGACACAGATCGAGGAGGCCCGG       c.1980
 S  A  C  E  L  R  E  A  A  C  L  Q  Q  T  Q  I  E  E  A  R         p.660

          .          | 11        .         .         .         .    g.29027
 GCAGGGCCGTGCGAGCAGG | CCGAGTGCGGTTCCGGAGGCTCTGGCTCTGGGGAGGACGGT    c.2040
 A  G  P  C  E  Q  A |   E  C  G  S  G  G  S  G  S  G  E  D  G      p.680

          .         .         .         .         .         .       g.29087
 GACTGTGAGCAGGAGCTGTGCCGGCAGCGCGGTGGCATCTGGGACGAGGACTCGGAGGAC       c.2100
 D  C  E  Q  E  L  C  R  Q  R  G  G  I  W  D  E  D  S  E  D         p.700

          .         .         .         .         | 12         .    g.29223
 GGGCCGTGTGTCTGTGACTTCAGCTGCCAGAGTGTCCCAGGCAGCCCG | GTGTGCGGCTCA    c.2160
 G  P  C  V  C  D  F  S  C  Q  S  V  P  G  S  P   | V  C  G  S      p.720

          .         .         .         .         .         .       g.29283
 GATGGGGTCACCTACAGCACCGAGTGTGAGCTGAAGAAGGCCAGGTGTGAGTCACAGCGA       c.2220
 D  G  V  T  Y  S  T  E  C  E  L  K  K  A  R  C  E  S  Q  R         p.740

          .         .         .     | 13   .         .         .    g.30064
 GGGCTCTACGTAGCGGCCCAGGGAGCCTGCCGAG | GCCCCACCTTCGCCCCGCTGCCGCCT    c.2280
 G  L  Y  V  A  A  Q  G  A  C  R  G |   P  T  F  A  P  L  P  P      p.760

          .         .         .         .         .         .       g.30124
 GTGGCCCCCTTACACTGTGCCCAGACGCCCTACGGCTGCTGCCAGGACAATATCACCGCA       c.2340
 V  A  P  L  H  C  A  Q  T  P  Y  G  C  C  Q  D  N  I  T  A         p.780

          .         .         .  | 14      .         .         .    g.30265
 GCCCGGGGCGTGGGCCTGGCTGGCTGCCCCA | GTGCCTGCCAGTGCAACCCCCATGGCTCT    c.2400
 A  R  G  V  G  L  A  G  C  P  S |   A  C  Q  C  N  P  H  G  S      p.800

          .         .         .         .         .         .       g.30325
 TACGGCGGCACCTGTGACCCAGCCACAGGCCAGTGCTCCTGCCGCCCAGGTGTGGGGGGC       c.2460
 Y  G  G  T  C  D  P  A  T  G  Q  C  S  C  R  P  G  V  G  G         p.820

          .         .         .         .         .         .       g.30385
 CTCAGGTGTGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGAGGCATCGTCACCGATGGC       c.2520
 L  R  C  D  R  C  E  P  G  F  W  N  F  R  G  I  V  T  D  G         p.840

          .       | 15 .         .         .         .         .    g.30654
 CGGAGTGGCTGTACAC | CCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGATGACTGTGAG    c.2580
 R  S  G  C  T  P |   C  S  C  D  P  Q  G  A  V  R  D  D  C  E      p.860

          .         .         .         .         .         .       g.30714
 CAGATGACGGGGCTGTGCTCGTGTAAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGTGT       c.2640
 Q  M  T  G  L  C  S  C  K  P  G  V  A  G  P  K  C  G  Q  C         p.880

          .         .         .         . | 16       .         .    g.30861
 CCAGACGGCCGTGCCCTGGGCCCCGCGGGCTGTGAAGCTG | ACGCTTCTGCGCCTGCGACC    c.2700
 P  D  G  R  A  L  G  P  A  G  C  E  A  D |   A  S  A  P  A  T      p.900

          .         .         .         .         .         .       g.30921
 TGTGCGGAGATGCGCTGTGAGTTCGGTGCGCGGTGCGTGGAGGAGTCTGGCTCAGCCCAC       c.2760
 C  A  E  M  R  C  E  F  G  A  R  C  V  E  E  S  G  S  A  H         p.920

          .         .         .         .      | 17  .         .    g.31052
 TGTGTCTGCCCGATGCTCACCTGTCCAGAGGCCAACGCTACCAAG | GTCTGTGGGTCAGAT    c.2820
 C  V  C  P  M  L  T  C  P  E  A  N  A  T  K   | V  C  G  S  D      p.940

          .         .         .         .         .         .       g.31112
 GGAGTCACATACGGCAACGAGTGTCAGCTGAAGACCATCGCCTGCCGCCAGGGCCTGCAA       c.2880
 G  V  T  Y  G  N  E  C  Q  L  K  T  I  A  C  R  Q  G  L  Q         p.960

          .         .         .  | 18      .         .         .    g.31303
 ATCTCTATCCAGAGCCTGGGCCCGTGCCAGG | AGGCTGTTGCTCCCAGCACTCACCCGACA    c.2940
 I  S  I  Q  S  L  G  P  C  Q  E |   A  V  A  P  S  T  H  P  T      p.980

          .         .         .         .         .         .       g.31363
 TCTGCCTCCGTGACTGTGACCACCCCAGGGCTCCTCCTGAGCCAGGCACTGCCGGCCCCC       c.3000
 S  A  S  V  T  V  T  T  P  G  L  L  L  S  Q  A  L  P  A  P         p.1000

          .         .         .         .         .         .       g.31423
 CCCGGCGCCCTCCCCCTGGCTCCCAGCAGTACCGCACACAGCCAGACCACCCCTCCGCCC       c.3060
 P  G  A  L  P  L  A  P  S  S  T  A  H  S  Q  T  T  P  P  P         p.1020

          .         .         .         .         .         .       g.31483
 TCATCACGACCTCGGACCACTGCCAGCGTCCCCAGGACCACCGTGTGGCCCGTGCTGACG       c.3120
 S  S  R  P  R  T  T  A  S  V  P  R  T  T  V  W  P  V  L  T         p.1040

          .         .         .         .         .         .       g.31543
 GTGCCCCCCACGGCACCCTCCCCTGCACCCAGCCTGGTGGCGTCCGCCTTTGGTGAATCT       c.3180
 V  P  P  T  A  P  S  P  A  P  S  L  V  A  S  A  F  G  E  S         p.1060

          .         .         .         .         .         .       g.31603
 GGCAGCACTGATGGAAGCAGCGATGAGGAACTGAGCGGGGACCAGGAGGCCAGTGGGGGT       c.3240
 G  S  T  D  G  S  S  D  E  E  L  S  G  D  Q  E  A  S  G  G         p.1080

          . | 19       .         .         .         .         .    g.31747
 GGCTCTGGGG | GGCTCGAGCCCTTGGAGGGCAGCAGCGTGGCCACCCCTGGGCCACCTGTC    c.3300
 G  S  G  G |   L  E  P  L  E  G  S  S  V  A  T  P  G  P  P  V      p.1100

          .         .         .         .         .         .       g.31807
 GAGAGGGCTTCCTGCTACAACTCCGCGTTGGGCTGCTGCTCTGATGGGAAGACGCCCTCG       c.3360
 E  R  A  S  C  Y  N  S  A  L  G  C  C  S  D  G  K  T  P  S         p.1120

          .         .         | 20         .         .         .    g.32236
 CTGGACGCAGAGGGCTCCAACTGCCCCG | CCACCAAGGTGTTCCAGGGCGTCCTGGAGCTG    c.3420
 L  D  A  E  G  S  N  C  P  A |   T  K  V  F  Q  G  V  L  E  L      p.1140

          .         .         .         .         .         .       g.32296
 GAGGGCGTCGAGGGCCAGGAGCTGTTCTACACGCCCGAGATGGCTGACCCCAAGTCAGAA       c.3480
 E  G  V  E  G  Q  E  L  F  Y  T  P  E  M  A  D  P  K  S  E         p.1160

          .         .         .       | 21 .         .         .    g.32474
 CTGTTCGGGGAGACAGCCAGGAGCATTGAGAGCACC | CTGGACGACCTCTTCCGGAATTCA    c.3540
 L  F  G  E  T  A  R  S  I  E  S  T   | L  D  D  L  F  R  N  S      p.1180

          .         .         .         .         .         .       g.32534
 GACGTCAAGAAGGATTTTCGGAGTGTCCGCTTGCGGGACCTGGGGCCCGGCAAATCCGTC       c.3600
 D  V  K  K  D  F  R  S  V  R  L  R  D  L  G  P  G  K  S  V         p.1200

          .         .         .  | 22      .         .         .    g.32682
 CGCGCCATTGTGGATGTGCACTTTGACCCCA | CCACAGCCTTCAGGGCACCCGACGTGGCC    c.3660
 R  A  I  V  D  V  H  F  D  P  T |   T  A  F  R  A  P  D  V  A      p.1220

          .         .         .         .         .         .       g.32742
 CGGGCCCTGCTCCGGCAGATCCAGGTGTCCAGGCGCCGGTCCTTGGGGGTGAGGCGGCCG       c.3720
 R  A  L  L  R  Q  I  Q  V  S  R  R  R  S  L  G  V  R  R  P         p.1240

          .         .         .  | 23      .         .         .    g.32918
 CTGCAGGAGCACGTGCGATTTATGGACTTTG | ACTGGTTTCCTGCGTTTATCACGGGGGCC    c.3780
 L  Q  E  H  V  R  F  M  D  F  D |   W  F  P  A  F  I  T  G  A      p.1260

          .         .         .         .         .         .       g.32978
 ACGTCAGGAGCCATTGCTGCGGGAGCCACGGCCAGAGCCACCACTGCATCGCGCCTGCCG       c.3840
 T  S  G  A  I  A  A  G  A  T  A  R  A  T  T  A  S  R  L  P         p.1280

          .         .         .         .         .         .       g.33038
 TCCTCTGCTGTGACCCCTCGGGCCCCGCACCCCAGTCACACAAGCCAGCCCGTTGCCAAG       c.3900
 S  S  A  V  T  P  R  A  P  H  P  S  H  T  S  Q  P  V  A  K         p.1300

          .         .         .         .         .         .       g.33098
 ACCACGGCAGCCCCCACCACACGTCGGCCCCCCACCACTGCCCCCAGCCGTGTGCCCGGA       c.3960
 T  T  A  A  P  T  T  R  R  P  P  T  T  A  P  S  R  V  P  G         p.1320

          .         .         .         .         .         .       g.33158
 CGTCGGCCCCCGGCCCCCCAGCAGCCTCCAAAGCCCTGTGACTCACAGCCCTGCTTCCAC       c.4020
 R  R  P  P  A  P  Q  Q  P  P  K  P  C  D  S  Q  P  C  F  H         p.1340

          .         .         .         .         .         .       g.33218
 GGGGGGACCTGCCAGGACTGGGCATTGGGCGGGGGCTTCACCTGCAGCTGCCCGGCAGGC       c.4080
 G  G  T  C  Q  D  W  A  L  G  G  G  F  T  C  S  C  P  A  G         p.1360

          .         .      | 24  .         .         .         .    g.33779
 AGGGGAGGCGCCGTCTGTGAGAAGG | TGCTTGGCGCCCCTGTGCCGGCCTTCGAGGGCCGC    c.4140
 R  G  G  A  V  C  E  K  V |   L  G  A  P  V  P  A  F  E  G  R      p.1380

          .         .         .         .         .         .       g.33839
 TCCTTCCTGGCCTTCCCCACTCTCCGCGCCTACCACACGCTGCGCCTGGCACTGGAATTC       c.4200
 S  F  L  A  F  P  T  L  R  A  Y  H  T  L  R  L  A  L  E  F         p.1400

          .         .         .         .         .         .       g.33899
 CGGGCGCTGGAGCCTCAGGGGCTGCTGCTGTACAATGGCAACGCCCGGGGCAAGGACTTC       c.4260
 R  A  L  E  P  Q  G  L  L  L  Y  N  G  N  A  R  G  K  D  F         p.1420

          .         .         .         | 25         .         .    g.34135
 CTGGCATTGGCGCTGCTAGATGGCCGCGTGCAGCTCAG | GTTTGACACAGGTTCGGGGCCG    c.4320
 L  A  L  A  L  L  D  G  R  V  Q  L  R  |  F  D  T  G  S  G  P      p.1440

          .         .         .         .         .         .       g.34195
 GCGGTGCTGACCAGTGCCGTGCCGGTAGAGCCGGGCCAGTGGCACCGCCTGGAGCTGTCC       c.4380
 A  V  L  T  S  A  V  P  V  E  P  G  Q  W  H  R  L  E  L  S         p.1460

          .         .         .         .         .         .       g.34255
 CGGCACTGGCGCCGGGGCACCCTCTCGGTGGATGGTGAGACCCCTGTTCTGGGCGAGAGT       c.4440
 R  H  W  R  R  G  T  L  S  V  D  G  E  T  P  V  L  G  E  S         p.1480

          .         .         .         .         .         .       g.34315
 CCCAGTGGCACCGACGGCCTCAACCTGGACACAGACCTCTTTGTGGGCGGCGTACCCGAG       c.4500
 P  S  G  T  D  G  L  N  L  D  T  D  L  F  V  G  G  V  P  E         p.1500

          .     | 26   .         .         .         .         .    g.34489
 GACCAGGCTGCCGT | GGCGCTGGAGCGGACCTTCGTGGGCGCCGGCCTGAGGGGGTGCATC    c.4560
 D  Q  A  A  V  |  A  L  E  R  T  F  V  G  A  G  L  R  G  C  I      p.1520

          .         .         .         .         .         .       g.34549
 CGTTTGCTGGACGTCAACAACCAGCGCCTGGAGCTTGGCATTGGGCCGGGGGCTGCCACC       c.4620
 R  L  L  D  V  N  N  Q  R  L  E  L  G  I  G  P  G  A  A  T         p.1540

          .         .         .         .         .         .       g.34609
 CGAGGCTCTGGCGTGGGCGAGTGCGGGGACCACCCCTGCCTGCCCAACCCCTGCCATGGC       c.4680
 R  G  S  G  V  G  E  C  G  D  H  P  C  L  P  N  P  C  H  G         p.1560

          .         .         .         .         .         .       g.34669
 GGGGCCCCATGCCAGAACCTGGAGGCTGGAAGGTTCCATTGCCAGTGCCCGCCCGGCCGC       c.4740
 G  A  P  C  Q  N  L  E  A  G  R  F  H  C  Q  C  P  P  G  R         p.1580

      | 27   .         .         .         .         .         .    g.34836
 GTCG | GACCAACCTGTGCCGATGAGAAGAGCCCCTGCCAGCCCAACCCCTGCCATGGGGCG    c.4800
 V  G |   P  T  C  A  D  E  K  S  P  C  Q  P  N  P  C  H  G  A      p.1600

          .         .         .         .         .         .       g.34896
 GCGCCCTGCCGTGTGCTGCCCGAGGGTGGTGCTCAGTGCGAGTGCCCCCTGGGGCGTGAG       c.4860
 A  P  C  R  V  L  P  E  G  G  A  Q  C  E  C  P  L  G  R  E         p.1620

          .          | 28        .         .         .         .    g.35151
 GGCACCTTCTGCCAGACAG | CCTCGGGGCAGGACGGCTCTGGGCCCTTCCTGGCTGACTTC    c.4920
 G  T  F  C  Q  T  A |   S  G  Q  D  G  S  G  P  F  L  A  D  F      p.1640

          .         .         .         .         .       | 29 .    g.35308
 AACGGCTTCTCCCACCTGGAGCTGAGAGGCCTGCACACCTTTGCACGGGACCTGGG | GGAG    c.4980
 N  G  F  S  H  L  E  L  R  G  L  H  T  F  A  R  D  L  G  |  E      p.1660

          .         .         .         .         .         .       g.35368
 AAGATGGCGCTGGAGGTCGTGTTCCTGGCACGAGGCCCCAGCGGCCTCCTGCTCTACAAC       c.5040
 K  M  A  L  E  V  V  F  L  A  R  G  P  S  G  L  L  L  Y  N         p.1680

          .         .         .         .         .         .       g.35428
 GGGCAGAAGACGGACGGCAAGGGGGACTTCGTGTCGCTGGCACTGCGGGACCGCCGCCTG       c.5100
 G  Q  K  T  D  G  K  G  D  F  V  S  L  A  L  R  D  R  R  L         p.1700

          .         .         .         .  | 30      .         .    g.35622
 GAGTTCCGCTACGACCTGGGCAAGGGGGCAGCGGTCATCAG | GAGCAGGGAGCCAGTCACC    c.5160
 E  F  R  Y  D  L  G  K  G  A  A  V  I  R  |  S  R  E  P  V  T      p.1720

          .         .         .         .         .         .       g.35682
 CTGGGAGCCTGGACCAGGGTCTCACTGGAGCGAAACGGCCGCAAGGGTGCCCTGCGTGTG       c.5220
 L  G  A  W  T  R  V  S  L  E  R  N  G  R  K  G  A  L  R  V         p.1740

          .         .         .    | 31    .         .         .    g.36157
 GGCGACGGCCCCCGTGTGTTGGGGGAGTCCCCG | GTTCCGCACACCGTCCTCAACCTGAAG    c.5280
 G  D  G  P  R  V  L  G  E  S  P   | V  P  H  T  V  L  N  L  K      p.1760

          .         .         .         .         .         .       g.36217
 GAGCCGCTCTACGTAGGGGGCGCTCCCGACTTCAGCAAGCTGGCCCGTGCTGCTGCCGTG       c.5340
 E  P  L  Y  V  G  G  A  P  D  F  S  K  L  A  R  A  A  A  V         p.1780

          .         .         . | 32       .         .         .    g.36360
 TCCTCTGGCTTCGACGGTGCCATCCAGCTG | GTCTCCCTCGGAGGCCGCCAGCTGCTGACC    c.5400
 S  S  G  F  D  G  A  I  Q  L   | V  S  L  G  G  R  Q  L  L  T      p.1800

          .         .         .         .         .         .       g.36420
 CCGGAGCACGTGCTGCGGCAGGTGGACGTCACGTCCTTTGCAGGTCACCCCTGCACCCGG       c.5460
 P  E  H  V  L  R  Q  V  D  V  T  S  F  A  G  H  P  C  T  R         p.1820

          .         .         .         .         .         .       g.36480
 GCCTCAGGCCACCCCTGCCTCAATGGGGCCTCCTGCGTCCCGAGGGAGGCTGCCTATGTG       c.5520
 A  S  G  H  P  C  L  N  G  A  S  C  V  P  R  E  A  A  Y  V         p.1840

          .         .         .         .    | 33    .         .    g.36622
 TGCCTGTGTCCCGGGGGATTCTCAGGACCGCACTGCGAGAAGG | GGCTGGTGGAGAAGTCA    c.5580
 C  L  C  P  G  G  F  S  G  P  H  C  E  K  G |   L  V  E  K  S      p.1860

          .         .         .         .         .         .       g.36682
 GCGGGGGACGTGGATACCTTGGCCTTTGACGGGCGGACCTTTGTCGAGTACCTCAACGCT       c.5640
 A  G  D  V  D  T  L  A  F  D  G  R  T  F  V  E  Y  L  N  A         p.1880

          .  | 34      .         .         .         .         .    g.38679
 GTGACCGAGAG | CGAGAAGGCACTGCAGAGCAACCACTTTGAACTGAGCCTGCGCACTGAG    c.5700
 V  T  E  S  |  E  K  A  L  Q  S  N  H  F  E  L  S  L  R  T  E      p.1900

          .         .         .         .         .         .       g.38739
 GCCACGCAGGGGCTGGTGCTCTGGAGTGGCAAGGCCACGGAGCGGGCAGACTATGTGGCA       c.5760
 A  T  Q  G  L  V  L  W  S  G  K  A  T  E  R  A  D  Y  V  A         p.1920

          .         .         .         .         .         .       g.38799
 CTGGCCATTGTGGACGGGCACCTGCAACTGAGCTACAACCTGGGCTCCCAGCCCGTGGTG       c.5820
 L  A  I  V  D  G  H  L  Q  L  S  Y  N  L  G  S  Q  P  V  V         p.1940

          .         .         .         .         .       | 35 .    g.39329
 CTGCGTTCCACCGTGCCCGTCAACACCAACCGCTGGTTGCGGGTCGTGGCACATAG | GGAG    c.5880
 L  R  S  T  V  P  V  N  T  N  R  W  L  R  V  V  A  H  R  |  E      p.1960

          .         .         .         .         .         .       g.39389
 CAGAGGGAAGGTTCCCTGCAGGTGGGCAATGAGGCCCCTGTGACCGGCTCCTCCCCGCTG       c.5940
 Q  R  E  G  S  L  Q  V  G  N  E  A  P  V  T  G  S  S  P  L         p.1980

          .         .         .         . | 36       .         .    g.39721
 GGCGCCACGCAGCTGGACACTGATGGAGCCCTGTGGCTTG | GGGGCCTGCCGGAGCTGCCC    c.6000
 G  A  T  Q  L  D  T  D  G  A  L  W  L  G |   G  L  P  E  L  P      p.2000

          .         .         .         .         .         .       g.39781
 GTGGGCCCAGCACTGCCCAAGGCCTACGGCACAGGCTTTGTGGGCTGCTTGCGGGACGTG       c.6060
 V  G  P  A  L  P  K  A  Y  G  T  G  F  V  G  C  L  R  D  V         p.2020

          .         .         .         .         .         .       g.39841
 GTGGTGGGCCGGCACCCGCTGCACCTGCTGGAGGACGCCGTCACCAAGCCAGAGCTGCGG       c.6120
 V  V  G  R  H  P  L  H  L  L  E  D  A  V  T  K  P  E  L  R         p.2040

          .                                                         g.39859
 CCCTGCCCCACCCCATGA                                                 c.6138
 P  C  P  T  P  X                                                   p.2045

          .         .         .         .         .         .       g.39919
 gctggcaccagagccccgcgcccgctgtaattattttctatttttgtaaacttgttgctt       c.*60

          .         .         .         .         .         .       g.39979
 tttgatatgattttcttgcctgagtgttggccggagggactgctggcccggcctcccttc       c.*120

          .         .         .         .         .         .       g.40039
 cgtccaggcagccgtgctgcagacagacctagtgccgagggatggacaggcgaggtggca       c.*180

          .         .         .         .         .         .       g.40099
 gcgtggagggctcggcgtggatggcagcctcaggacacacacccctgcctcaaggtgctg       c.*240

          .         .         .         .         .         .       g.40159
 agcccccgccttgcactgcgcctgccccacggtgtccccgccgggaagcagccccggctc       c.*300

          .         .         .         .         .         .       g.40219
 ctgaatcaccctcgctccgtcaggcgggactcgtgtcccagagaggaaggggctgctgag       c.*360

          .         .         .         .         .         .       g.40279
 gtctgatggggcccttcctccgggtgaccccacagggcctttccaagcccccatttgagc       c.*420

          .         .         .         .         .         .       g.40339
 tgctccttcctgtgtgtgctctgggccctgcctcggcctcctgcgccaatactgtgactt       c.*480

          .         .         .         .         .         .       g.40399
 ccaaacaatgttactgctgggcacagctctgcgttgctcccgtgctgcctgcgccagccc       c.*540

          .         .         .         .         .         .       g.40459
 caggctgctgaggagcagaggccagaccagggccgatctgggtgtcctgaccctcagctg       c.*600

          .         .         .         .         .         .       g.40519
 gccctgcccagccaccctggacgtgaccgtatccctctgccacaccccaggccctgcgag       c.*660

          .         .         .         .         .         .       g.40579
 gggctatcgagaggagctcactgtgggatggggttgacctctgccgcctgcctgggtatc       c.*720

          .         .         .         .         .         .       g.40639
 tgggcctggccatggctgtgttcttcatgtgttgattttatttgacccctggagtggtgg       c.*780

          .         .         .         .         .         .       g.40699
 gtctcatctttcccatctcgcctgagagcggctgagggctgcctcactgcaaatcctccc       c.*840

          .         .         .         .         .         .       g.40759
 cacagcgtcagtgaaagtcgtccttgtctcagaatgaccaggggccagccagtgtctgac       c.*900

          .         .         .         .         .         .       g.40819
 caaggtcaaggggcaggtgcagaggtggcagggatggctccgaagccagaaatgccttaa       c.*960

          .         .         .         .         .         .       g.40879
 actgcaacgtcccgtcccttccccacccccatcccatccccacccccagccccagcccag       c.*1020

          .         .         .         .         .         .       g.40939
 tcctcctaggagcaggacccgatgaagcgggcggcggtggggctgggtgccgtgttacta       c.*1080

          .         .         .         .         .                 g.40990
 actctagtatgtttctgtgtcaatcgctgtgaaataaagtctgaaaacttt                c.*1131

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Agrin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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