Leiden Muscular Dystrophy pages©

Titin (TTN) gene table

(last modified February 10, 2006)

ExonSize
(in bp)		Size intron
(in bp)		5'cDNA positionSplice afterRemarks
11202556  5' UTR
21042210  13 bp 5' UTR, (Z1a domain) Ig1a
32041455  (Z1b domain) Ig1b
4288484  (Z2 domain) Ig2
58693  unique
62454234  unique
7331370  Ig3
8153857  Zr1 (Z-repeat 1)
91381206  Zr2
101261232  Zr3
11138592  Zr4
12138480  Zr5
131383218  Zr6
14294105  Zr7, unique
151231268  unique
16282284  unique
1766655  unique
18259203  Ig-repeat
1964111  unique
20216948  Ig-repeat
21143915  Ig-repeat
22206537  unique
23234110  unique, Ig-repeat
24245898  Ig-repeat, unique
25272119  unique, Ig-repeat
26165102  Ig-repeat, unique
2716999  unique, Ig-repeat
281694153  Ig-repeat/unique (4), Ig-repeat
29282447  Ig-repeat
3026796  Ig-repeat
31273112  Ig-repeat
3226492  Ig-repeat
332611637  Ig-repeat
34261535  Ig-repeat
3526491  Ig-repeat
36261120  Ig-repeat
37261745  Ig-repeat
38261517  Ig-repeat
3914289  Ig-repeat
401661146  Ig-repeat
412321569  Ig-repeat
42285224  Ig-repeat
431265004  Ig-repeat
441891067  Ig-repeat
45375744  Ig-repeat
465763041  only one of these 2 is spliced; Ig16 splices to N2BNovex 1; Ig16
47571083  Novex 2; Ig17
4863983720   Novex-3 titin isoform, alternative 3' end; Ig18-Ig23; contains putative obscurin binding site
492781780   heart-specific N2B exon; Ig24-Ig26
502792007  end titin isoforms novex-1/2; Ig-repeat
51564522  Ig-repeat
52282100  Ig-repeat
53279435  Ig-repeat
5427996  Ig-repeat
55279117  Ig-repeat
56288115  Ig-repeat
5727992  Ig-repeat
5828294  Ig-repeat
59279109  Ig-repeat
60279101  Ig-repeat
61279132  Ig-repeat
62288133  Ig-repeat
63279147  Ig-repeat
6428297  Ig-repeat
65279118  Ig-repeat
66279112  Ig-repeat
67279102  Ig-repeat
68288246  Ig-repeat
69279213  Ig-repeat
702821043  Ig-repeat
71279118  Ig-repeat
72282829  Ig-repeat
73279116  Ig-repeat
74288159  Ig-repeat
7527993  Ig-repeat
76279108  Ig-repeat
77279112  Ig-repeat
78288124  Ig-repeat
79288644  Ig-repeat
80282257  Ig-repeat
81279120  Ig-repeat
82282150  Ig-repeat
83279102  Ig-repeat
84288190  Ig-repeat
8527994  Ig-repeat
86279100  Ig-repeat
87279132  Ig-repeat
88288140  Ig-repeat
892881320  Ig-repeat
90282228  Ig-repeat
91279412  Ig-repeat
92282116  Ig-repeat
93279524  Ig-repeat
94288109  Ig-repeat
95279103  Ig-repeat
9627992  Ig-repeat
97279594  Ig-repeat
98288139  Ig-repeat
99288778  Ig-repeat
1002911752  Ig-repeat
101288571  Ig-79
10293122  unique
1032861096  Ig-repeat
104184207  unique
1059099  unique
106268102  Ig-repeat
1072611483  Ig-repeat
108210208  Ig-83
10978101  Ig-repeat
11027452  unique
11160324  unique
112842205  PEVK
113721674  PEVK
11448851  PEVK
115405454  PEVK
11663441  PEVK
11778152  PEVK
11878590  PEVK
11987232  PEVK
120811028  PEVK
12184397  PEVK
122841629  PEVK
12342448  putative PEVK exon
12484217  PEVK
12581141  PEVK
12684153  PEVK
12784274  PEVK
128102452  PEVK
1291142512  PEVK
13081187  PEVK
13178263  PEVK
13284156  PEVK
13384252  PEVK
13484247  PEVK
13584707  PEVK
13681307  PEVK
137207958  PEVK
13878210  PEVK
13975204  PEVK
14093747  PEVK
14178198  PEVK
142162211  PEVK
14384182  PEVK
14478508  PEVK
14584249  PEVK
14684205  PEVK
14784207  PEVK
1482971625  PEVK
14975166  PEVK
15084557  putative PEVK exon
15175629  PEVK
15296603  PEVK
15378929  PEVK
15469153  PEVK
15575139  PEVK
156297800  PEVK
15781794  PEVK
15878542  PEVK
15984144  putative PEVK exon
160751651  putative PEVK exon
16184112  putative start fetal titin isoform
16284122  PEVK
16384334  PEVK
164781036  PEVK
16584247  putative PEVK exon
16684450  PEVK
16775114  PEVK
16884116  PEVK
16978361  PEVK
17084112  PEVK; alternatively spliced 45 nucleotides upstream in intron 169
17184108  PEVK
17284110  PEVK
1738483  repeat-Arepeat-A
17484210  PEVK
17590153  PEVK
17684112  PEVK
17784114  PEVK
17881115  putative PEVK exon
17981113  putative PEVK exon
18081105  PEVK
181842503  putative PEVK exon
1828483  putative PEVK exonrepeat-B
18384210  putative PEVK exon
18490153  PEVK
18584112  putative PEVK exon
18684114  (PEVK 86) putative PEVK exon
18781115  putative PEVK exon
18881113  putative PEVK exon
18981105  putative PEVK exon
190842502  putative PEVK exon
1918483  PEVKrepeat-C
19284210  PEVK
19390153  putative PEVK exon
19484112  putative PEVK exon
19584114  putative PEVK exon
19681115  putative PEVK exon
19781113  putative PEVK exon
19881111  putative PEVK exon
19978113  putative PEVK exon 
20084304  PEVK
20184111  putative PEVK exon
20284110  putative PEVK exon
2038484  PEVK
20484128  PEVK
20584134  PEVK
20684129  PEVK
20784132  PEVK
20878408  PEVK
20984479  PEVK
210108269  PEVK
21178185  PEVK
21278222  putative PEVK exon
213841783  putative PEVK exon
21484236  putative PEVK exon
21581504  putative PEVK exon
21675454  putative PEVK exon
2171111303  PEVK
218692230  PEVK
21981921  PEVK
22075610  PEVK
22190430  PEVK
22263259  PEVK
223902279  PEVK
22451569  PEVK
225402156  PEVK, Ig-repeat
226279247  Ig-repeat
227276135  Ig-repeat
228140315  Ig-repeat
22912793  Ig-repeat
230264282  Ig-repeat
231267140  Ig-repeat
23226486  Ig-repeat
233140142  Ig-repeat
234127125  Ig-repeat
235267112  Ig-repeat
236267846  Ig-repeat
23726790  Ig-repeat
238140436  Ig-repeat
239127797  Ig-repeat
2401433904  Ig-repeat
241124541  Ig-repeat
2422671697  Ig-repeat
24398661  Ig-repeat
24416998  Ig-repeat
245267106  Ig-repeat
246267108  Ig-repeat
24727989  Ig-repeat
248409104  Ig-repeat
249125100  Ig-repeat
250267767  Ig-repeat
25127092  Ig105
252303107  Fn-III
253303266  Fn-III
25418890  Fn-III
255115106  Fn-III
25628598  Ig-repeat
257152690  Fn-III
258148156  Fn-III
259178338  Fn-III
26012293  Fn-III
261288117  Fn-III
262297114  Fn-III
263187474  Fn-III
26411688  Fn-III
265300196  Fn-III
266300114  Fn-III
267106102  Fn-III
26819780  Fn-III
269306100  Ig-repeat
270279603  Fn-III
271300103  Fn-III
272303113  Ig-repeat
273363299  Fn-III
274303128  Fn-III
27530096  Fn-III
27629799  
27728586  Ig-repeat
2782941307  Fn-III
279300118  Fn-III
28030988  Ig-repeat
281191402  Fn-III
2824301285  Fn-III
283309131  Fn-III
28414987  Ig-repeat
2853394  Ig-repeat
28613093  Ig-repeat
28730093  Fn-III
2883191003  Fn-III
289296108  Ig-repeat
29030083  Fn-III
29131593  Fn-III
292149447  Fn-III
29315188  Fn-III
2942821728  Ig-repeat
295303860  Fn-III
296303101  Fn-III
29728293  Ig-repeat
29830092  Fn-III
29930389  Fn-III
300309114  Fn-III
301282101  Ig-repeat
30230085  Fn-III
30329494  Fn-III
3042967318  Ig-repeat, Fn-III (3), Ig-repeat, Fn-III (2), Ig-repeat, Fn-III (2)
30532198  Fn-III
30628598  Ig-repeat
307300310  Fn-III
3083031157  (A45) Fn-III
309276103  Ig-repeat
31030090  Fn-III
311303369  Fn-III
312300379  Fn-III
313288347  Ig-repeat
31429787  Fn-III
315303101  Fn-III
316306889  Fn-III
31728892  Ig-repeat
31829190  Fn-III
319288167  Fn-III
32058890  Ig-repeat, Fn-III
321105425  Fn-III
32219889  Fn-III
32329791  Fn-III
32458891  Ig-repeat, Fn-III
325303112  Fn-III
32617106673  42 Fn-III, 16 Ig-repeat
327297105  Fn-III
32858892  Ig-repeat, Fn-III
329303108  Fn-III
3302971695  Fn-III
331288112  Ig-repeat
332300236  Fn-III
333303106  Fn-III
334306105  Fn-III
3351767369  2 Ig-repeat, 4 Fn-III
336294693  Fn-III
337288116  Ig-repeat
33830096  Fn-III
3392067101  2 Ig-repeat, 5 Fn-III
34030397  Fn-III
34130697  Fn-III
34229195  (A149) Ig-repeat
343297126  
344306881  
34530685  Fn-III
346282171  Ig-repeat
347594119  Fn-III
34828898  Ig-repeat
349300679  Fn-III
350303911  Fn-III
351303101  Fn-III
352585130  Ig-repeat, Fn-III
353306106  Fn-III
354300622  Fn-III
35557698  Ig-repeat
356306362  (A166) Fn-III
357594132  Fn-III, Ig-repeat
3585609124  (Mex1) Ig-repeat, Fn-III, kinase domain, M1-M3, unique, myomesin binding site/M4, M5-M7a
359157740  (Mex2) M7b
360692100  (Mex3) unique, M8
361154525  (Mex4) M9a
362303138  (Mex5) unique; CAPN3 binding site
3631371-  (Mex6) M9b-M10, 3' UTR

Legend:
Exon: numbering of exons is as determined by Bang et al. (2001). Exon size: size of exon indicated in base pairs. Intron size: size of intron indicated in base pairs. 5' cDNA position: first base of the exon (according to coding DNA Reference Sequence). Splice after: splicing occurs in between of two coding triplets (0), after the first (1) or the second (2) base of a triplet. Remarks: 5' UTR = 5' untranslated region, 3' UTR = 3' untranslated region, protein domains (Fn-III, Ig-repeat, M-repeat, PEVK).

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