LOCUS       HSLGMD2C1     400 bp    DNA             PRI       02-NOV-1996
DEFINITION  Human gamma-sarcoglycan (LGMD 2c) gene, exon 1.
ACCESSION   U63388
NID         g1655861
KEYWORDS    .
SEGMENT     1 of 8
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 400)
  AUTHORS   McNally,E.M., Passos-Bueno,M.R., Bonnemann,C.G., Vainzof,M., de Sa
            Moreira,E., Lidov,H.G.W., Othmane,K.B., Denton,P.H., Vance,J.M.,
            Zatz,M. and Kunkel,L.M.
  TITLE     Mild and severe muscular dystrophy caused by a single
            gamma-sarcoglycan mutation
  JOURNAL   Am. J. Hum. Genet. 59 (5), 1040-1047 (1996)
  MEDLINE   97055886
REFERENCE   2  (bases 1 to 400)
  AUTHORS   McNally,Elizabeth.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUL-1996) Genetics, Children's Hospital, 300 Longwood
            Avenue, Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Homo sapiens"
                     /chromosome="13"
                     /map="13q12"
     exon            253..376
                     /gene="LGMD 2c"
                     /number=1
     5'UTR           253..376
                     /gene="LGMD 2c"
BASE COUNT       93 a     63 c    102 g    142 t
ORIGIN      
        1 ctatcatgct ttagggttta aatgttggaa agttggtttt gtaagaagaa gagtttggtt
       61 tcttgtttgc ttgtttgttt tggtttgttt ttggcatgcg aagagctgtg tcctggaatt
      121 ggtgcccccc aaattttaag tgtggtatga actgtttatg tcactgagta aaattagaca
      181 cgtctgttgc taatgtgagg ggatgaaaca tgagacaggg cgaaactcgt gagagccctt
      241 tctccaggga cagttgctga agcttcatcc tttgctctca ttctgtaagt catagaaaag
      301 tttgaaacat tctgtctgtg gtagagctcg ggccagctgt agttcattcg ccagtgtgct
      361 tttcttaata tctaaggtaa gtgctcagtt ttaacttaga 
//
LOCUS       HSLGMD2C2     256 bp    DNA             PRI       02-NOV-1996
DEFINITION  Human gamma-sarcoglycan (LGMD 2c) gene, exon 2.
ACCESSION   U63389
NID         g1655862
KEYWORDS    .
SEGMENT     2 of 8
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 256)
  AUTHORS   McNally,E.M., Passos-Bueno,M.R., Bonnemann,C.G., Vainzof,M., de Sa
            Moreira,E., Lidov,H.G.W., Othmane,K.B., Denton,P.H., Vance,J.M.,
            Zatz,M. and Kunkel,L.M.
  TITLE     Mild and severe muscular dystrophy caused by a single
            gamma-sarcoglycan mutation
  JOURNAL   Am. J. Hum. Genet. 59 (5), 1040-1047 (1996)
  MEDLINE   97055886
REFERENCE   2  (bases 1 to 256)
  AUTHORS   McNally,Elizabeth.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUL-1996) Genetics, Children's Hospital, 300 Longwood
            Avenue, Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..256
                     /organism="Homo sapiens"
                     /chromosome="13"
                     /map="13q12"
     exon            33..227
                     /gene="LGMD 2c"
                     /number=2
BASE COUNT       62 a     54 c     55 g     85 t
ORIGIN      
        1 ctctctcctc tcgtgaacac actccgtggc agatggtgcg tgagcagtac actacagcca
       61 cagaaggcat ctgcatagag aggccagaga atcagtatgt ctacaaaatt ggcatttatg
      121 gctggagaaa gcgctgtctc tacttgtttg ttcttctttt actcatcatc ctcgttgtga
      181 atttagctct tacaatttgg attcttaaag tgatgtggtt ttctccagta agtatcatta
      241 ttttctggta agcatg
//
LOCUS       HSLGMD2C3     166 bp    DNA             PRI       02-NOV-1996
DEFINITION  Human gamma-sarcoglycan (LGMD 2c) gene, exon 3.
ACCESSION   U63390
NID         g1655863
KEYWORDS    .
SEGMENT     3 of 8
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 166)
  AUTHORS   McNally,E.M., Passos-Bueno,M.R., Bonnemann,C.G., Vainzof,M., de Sa
            Moreira,E., Lidov,H.G.W., Othmane,K.B., Denton,P.H., Vance,J.M.,
            Zatz,M. and Kunkel,L.M.
  TITLE     Mild and severe muscular dystrophy caused by a single
            gamma-sarcoglycan mutation
  JOURNAL   Am. J. Hum. Genet. 59 (5), 1040-1047 (1996)
  MEDLINE   97055886
REFERENCE   2  (bases 1 to 166)
  AUTHORS   McNally,Elizabeth.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUL-1996) Genetics, Children's Hospital, 300 Longwood
            Avenue, Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..166
                     /organism="Homo sapiens"
                     /chromosome="13"
                     /map="13q12"
     exon            31..132
                     /gene="LGMD 2c"
                     /number=3
BASE COUNT       51 a     25 c     36 g     54 t
ORIGIN      
        1 tacgcattgt ctcttttttt tttttaacag gcaggaatgg gccacttgtg tgtaacaaaa
       61 gatggactgc gcttggaagg ggaatcagaa tttttattcc cattgtatgc caaagaaata
      121 cactccagag tggtaagaaa atgttaagac aaataatttg tgcttt
//
LOCUS       HSLGMD2C4     150 bp    DNA             PRI       02-NOV-1996
DEFINITION  Human gamma-sarcoglycan (LGMD 2c) gene, exon 4.
ACCESSION   U63391
NID         g1655864
KEYWORDS    .
SEGMENT     4 of 8
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 150)
  AUTHORS   McNally,E.M., Passos-Bueno,M.R., Bonnemann,C.G., Vainzof,M., de Sa
            Moreira,E., Lidov,H.G.W., Othmane,K.B., Denton,P.H., Vance,J.M.,
            Zatz,M. and Kunkel,L.M.
  TITLE     Mild and severe muscular dystrophy caused by a single
            gamma-sarcoglycan mutation
  JOURNAL   Am. J. Hum. Genet. 59 (5), 1040-1047 (1996)
  MEDLINE   97055886
REFERENCE   2  (bases 1 to 150)
  AUTHORS   McNally,Elizabeth.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUL-1996) Genetics, Children's Hospital, 300 Longwood
            Avenue, Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..150
                     /organism="Homo sapiens"
                     /chromosome="13"
                     /map="13q12"
     exon            39..126
                     /gene="LGMD 2c"
                     /number=4
BASE COUNT       42 a     35 c     32 g     41 t
ORIGIN      
        1 cagcacctat tttgcaaatt ttataaatct ctttctagga ctcatctctg cttctacaat
       61 caacccagaa tgtgactgta aatgcgcgca actcagaagg ggaggtcaca ggcaggttaa
      121 aagtcggtga gtccagcttc atcatggtgc 
//
LOCUS       HSLGMD2C5     229 bp    DNA             PRI       02-NOV-1996
DEFINITION  Human gamma-sarcoglycan (LGMD 2c) gene, exon 5.
ACCESSION   U63392
NID         g1655865
KEYWORDS    .
SEGMENT     5 of 8
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 229)
  AUTHORS   McNally,E.M., Passos-Bueno,M.R., Bonnemann,C.G., Vainzof,M., de Sa
            Moreira,E., Lidov,H.G.W., Othmane,K.B., Denton,P.H., Vance,J.M.,
            Zatz,M. and Kunkel,L.M.
  TITLE     Mild and severe muscular dystrophy caused by a single
            gamma-sarcoglycan mutation
  JOURNAL   Am. J. Hum. Genet. 59 (5), 1040-1047 (1996)
  MEDLINE   97055886
REFERENCE   2  (bases 1 to 229)
  AUTHORS   McNally,Elizabeth.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUL-1996) Genetics, Children's Hospital, 300 Longwood
            Avenue, Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..229
                     /organism="Homo sapiens"
                     /chromosome="13"
                     /map="13q12"
     exon            82..201
                     /gene="LGMD 2c"
                     /number=5
BASE COUNT       79 a     38 c     50 g     62 t
ORIGIN      
        1 gttgacgtgg catgtgtaaa aatagagatt tggacactgc ttgtagtgaa cagtttataa
       61 taaactgttt taattcttca ggtcccaaaa tggtagaagt ccagaatcaa cagtttcaga
      121 tcaactccaa cgacggcaag ccactattta ctgtagatga gaaggaagtt gtggttggta
      181 cagataaact tcgagtaact ggtatgtact aactcgagaa aaacacaac
//
LOCUS       HSLGMD2C6     198 bp    DNA             PRI       02-NOV-1996
DEFINITION  Human gamma-sarcoglycan (LGMD 2c) gene, exon 6.
ACCESSION   U63393
NID         g1655866
KEYWORDS    .
SEGMENT     6 of 8
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 198)
  AUTHORS   McNally,E.M., Passos-Bueno,M.R., Bonnemann,C.G., Vainzof,M., de Sa
            Moreira,E., Lidov,H.G.W., Othmane,K.B., Denton,P.H., Vance,J.M.,
            Zatz,M. and Kunkel,L.M.
  TITLE     Mild and severe muscular dystrophy caused by a single
            gamma-sarcoglycan mutation
  JOURNAL   Am. J. Hum. Genet. 59 (5), 1040-1047 (1996)
  MEDLINE   97055886
REFERENCE   2  (bases 1 to 198)
  AUTHORS   McNally,Elizabeth.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUL-1996) Genetics, Children's Hospital, 300 Longwood
            Avenue, Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Homo sapiens"
                     /chromosome="13"
                     /map="13q12"
     exon            53..125
                     /gene="LGMD 2c"
                     /number=6
BASE COUNT       48 a     38 c     43 g     69 t
ORIGIN      
        1 tggtgtcact tattttactt ctgctcctga tacatctttg ttttttgttt agggcctgaa
       61 ggggctcttt ttgaacattc agtggagaca ccccttgtca gagccgaccc gtttcaagac
      121 cttaggtaag aatttttgtt caaatattaa caacctctcc tgtagaagac aagagggtat
      181 gtgctggaat aatgttag
//
LOCUS       HSLGMD2C7     181 bp    DNA             PRI       02-NOV-1996
DEFINITION  Human gamma-sarcoglycan (LGMD 2c) gene, exon 7.
ACCESSION   U63394
NID         g1655867
KEYWORDS    .
SEGMENT     7 of 8
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 181)
  AUTHORS   McNally,E.M., Passos-Bueno,M.R., Bonnemann,C.G., Vainzof,M., de Sa
            Moreira,E., Lidov,H.G.W., Othmane,K.B., Denton,P.H., Vance,J.M.,
            Zatz,M. and Kunkel,L.M.
  TITLE     Mild and severe muscular dystrophy caused by a single
            gamma-sarcoglycan mutation
  JOURNAL   Am. J. Hum. Genet. 59 (5), 1040-1047 (1996)
  MEDLINE   97055886
REFERENCE   2  (bases 1 to 181)
  AUTHORS   McNally,Elizabeth.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUL-1996) Genetics, Children's Hospital, 300 Longwood
            Avenue, Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..181
                     /organism="Homo sapiens"
                     /chromosome="13"
                     /map="13q12"
     exon            27..150
                     /gene="LGMD 2c"
                     /number=7
BASE COUNT       42 a     41 c     40 g     58 t
ORIGIN      
        1 ttttgtgctt cttttcctca tctcagatta gaatccccca ctcggagtct aagcatggat
       61 gccccaaggg gtgtgcatat tcaagctcac gctgggaaaa ttgaggcgct ttctcaaatg
      121 gatattcttt ttcatagtag tgatggaatg gtgagttcat tcacagatca gcctcctact
      181 g
//
LOCUS       HSLGMD2C8     319 bp    DNA             PRI       02-NOV-1996
DEFINITION  Human gamma-sarcoglycan (LGMD 2c) gene, exon 8 and complete cds.
ACCESSION   U63395
NID         g1655868
KEYWORDS    .
SEGMENT     8 of 8
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   McNally,E.M., Passos-Bueno,M.R., Bonnemann,C.G., Vainzof,M., de Sa
            Moreira,E., Lidov,H.G.W., Othmane,K.B., Denton,P.H., Vance,J.M.,
            Zatz,M. and Kunkel,L.M.
  TITLE     Mild and severe muscular dystrophy caused by a single
            gamma-sarcoglycan mutation
  JOURNAL   Am. J. Hum. Genet. 59 (5), 1040-1047 (1996)
  MEDLINE   97055886
REFERENCE   2  (bases 1 to 319)
  AUTHORS   McNally,Elizabeth.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUL-1996) Genetics, Children's Hospital, 300 Longwood
            Avenue, Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Homo sapiens"
                     /chromosome="13"
                     /map="13q12"
     mRNA            join(U63388:253..376,U63389:33..227,U63390:31..132,
                     U63391:39..126,U63392:82..201,U63393:53..125,
                     U63394:27..150,36..>319)
                     /gene="LGMD 2c"
     CDS             join(U63389:33..227,U63390:31..132,U63391:39..126,
                     U63392:82..201,U63393:53..125,U63394:27..150,36..209)
                     /gene="LGMD 2c"
                     /codon_start=1
                     /translation="MVREQYTTATEGICIERPENQYVYKIGIYGWRKRCLYLFVLLLL
                     IILVVNLALTIWILKVMWFSPAGMGHLCVTKDGLRLEGESEFLFPLYAKEIHSRVDSS
                     LLLQSTQNVTVNARNSEGEVTGRLKVGPKMVEVQNQQFQINSNDGKPLFTVDEKEVVV
                     GTDKLRVTGPEGALFEHSVETPLVRADPFQDLRLESPTRSLSMDAPRGVHIQAHAGKI
                     EALSQMDILFHSSDGMLVLDAETVCLPKLVQGTWGPSGSSQSLYEICVCPDGKLYLSV
                     AGVSTTCQEHSHICL"
     exon            36..>319
                     /gene="LGMD 2c"
                     /number=8
     3'UTR           210..>319
                     /gene="LGMD 2c"
BASE COUNT       61 a     96 c     93 g     69 t
ORIGIN      
        1 ccttaactct tcgtctccca tcttctccca accagctcgt gcttgatgct gaaactgtgt
       61 gcttacccaa gctggtgcag gggacgtggg gtccctctgg cagctcacag agcctctacg
      121 aaatctgtgt gtgtccagat gggaagctgt acctgtctgt ggccggtgtg agcaccacgt
      181 gccaggagca cagccacatc tgcctctgag ctgcctgcgt cctctcggtg agctgtgcag
      241 tgccggcccc agatcctcac acccagggag caggtgcaca tcgtgaaaga ctgaggcagc
      301 gtggatggga agtaaacgc
//


