LOCUS NG_027758 7784 bp DNA linear PRI 02-APR-2012 DEFINITION Homo sapiens heat shock 27kDa protein 3 (HSPB3), RefSeqGene on chromosome 5. ACCESSION NG_027758 VERSION NG_027758.1 GI:307611937 KEYWORDS RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7784) AUTHORS Sugiyama,Y., Suzuki,A., Kishikawa,M., Akutsu,R., Hirose,T., Waye,M.M., Tsui,S.K., Yoshida,S. and Ohno,S. TITLE Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation JOURNAL J. Biol. Chem. 275 (2), 1095-1104 (2000) PUBMED 10625651 REFERENCE 2 (bases 1 to 7784) AUTHORS Boelens,W.C., Van Boekel,M.A. and De Jong,W.W. TITLE HspB3, the most deviating of the six known human small heat shock proteins JOURNAL Biochim. Biophys. Acta 1388 (2), 513-516 (1998) PUBMED 9858786 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092366.3. This sequence is a reference standard in the RefSeqGene project. Summary: This gene encodes a muscle-specific small heat shock protein. A mutation in this gene is the cause of autosomal dominant distal hereditary motor neuropathy type 2C.[provided by RefSeq, Sep 2010]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-7784 AC092366.3 139358-147141 FEATURES Location/Qualifiers source 1..7784 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="5" /map="5q11.2" gene 5001..5784 /gene="HSPB3" /gene_synonym="DHMN2C; HMN2C; HSPL27" /note="heat shock 27kDa protein 3" /db_xref="GeneID:8988" /db_xref="HGNC:5248" /db_xref="MIM:604624" mRNA 5001..5784 /gene="HSPB3" /gene_synonym="DHMN2C; HMN2C; HSPL27" /product="heat shock 27kDa protein 3" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_006308.2" /exception="annotated by transcript or proteomic data" /transcript_id="NM_006308.2" /db_xref="GI:306966173" /db_xref="GeneID:8988" /db_xref="HGNC:5248" /db_xref="MIM:604624" exon 5001..5784 /gene="HSPB3" /gene_synonym="DHMN2C; HMN2C; HSPL27" /inference="alignment:Splign:1.39.8" /number=1 STS 5082..5740 /gene="HSPB3" /gene_synonym="DHMN2C; HMN2C; HSPL27" /db_xref="UniSTS:486904" STS 5087..5890 /standard_name="HSPB3_202" /db_xref="UniSTS:280770" STS 5146..5693 /gene="HSPB3" /gene_synonym="DHMN2C; HMN2C; HSPL27" /db_xref="UniSTS:494604" STS 5153..5689 /gene="HSPB3" /gene_synonym="DHMN2C; HMN2C; HSPL27" /db_xref="UniSTS:482422" CDS 5190..5642 /gene="HSPB3" /gene_synonym="DHMN2C; HMN2C; HSPL27" /note="protein 3; HSP 17; heat shock 17 kDa protein" /codon_start=1 /product="heat shock protein beta-3" /protein_id="NP_006299.1" /db_xref="GI:5453688" /db_xref="CCDS:CCDS3961.1" /db_xref="GeneID:8988" /db_xref="HGNC:5248" /db_xref="MIM:604624" STS 5550..5671 /gene="HSPB3" /gene_synonym="DHMN2C; HMN2C; HSPL27" /standard_name="RH65243" /db_xref="UniSTS:85914" ORIGIN 1 aacctttcca cctggaaaga gactgcacct cccagggctg gccaatcctt agagacagca 61 aagggctcag ctgggagtgt gcctttgata cgcaaactgc ccaacccaga gccatctctc 121 ctctatgtgg cccctgcact ccaggacaca acattcctct gccttagtca accaaaggcc 181 aggtaccggg caattggaga catcctgtag cttagggcct gctgaaatta ttcaaactag 241 ccagttctaa actgttcatc ctgccctgcc tttccctgtg gaaaccccaa taatggctgt 301 ggctaaatct tccacttgct cctgtcttct gcctcctgac tgcttatgtc ttcctctcac 361 cctccatagc cagttgtctc taggacctgt gagtataaca tactttgttt tcccgagact 421 ctctcctgta tctcctcttg tgaccacacc gccctgatca tggcgtaaaa gaatacaaaa 481 aaaggtaaaa tagggttcta tgggctgggc acagtggctc acgcctgtaa tcccagcact 541 atgggaggcc gaggtgggca gatcacgagg tcaggagatc gagaccatcc tggctaacat 601 agtgaaatcc cgtctctacc aaaaaataca aaaaattagc cgggcatggt ggcgggcgcc 661 tgtcatccca gctattcggg aggctgaggc aggagaatgg tgtgaaccca ggaggtggag 721 cttgcagtga gccgagattg cgccactgca ctccagcctg ggcaacagag tgagactctg 781 tctcaaaaaa aaaaaaaaaa aaaattgggt tctatgatgg ataacaagag tactttccct 841 agatagttgg aaaagacttg gctgaagaag taacacgtga cctggagcct gaatgatgag 901 aaagaggcaa ctttaagaca acttgaaagt caagttttca gaacaaaagg gactccaagt 961 acaagaagcc tgaggaagaa ccaagcttag agtgttcaag ggacagacag gaggccagtg 1021 tggttgaagc aggggcacca ccattttacc tgtggtcacc agcatgcata aaatgtacaa 1081 cacgaagact gaaccctagt gtgaggtgga ggggagcagg gcagaggggc cagattatag 1141 gttctcaaag gccatggtaa gaattttata tttcattctg gttgtgatga gaaacttctg 1201 acttcaagtt tgaagcaagg gagtgacatc atctatgtga tgctctagaa caactgctct 1261 agttacaagg cgaaggatgg acaggagggc aggagaagga agcctgacag attctccaaa 1321 aggacaaaaa gtcaacgtag ctgatgatca tgatgagggc agtcacgctt agggctggag 1381 tcaaagggca gttttgggaa aattttggga aaatggcaga agtagaagtc ttgaatatcg 1441 catcagaaat gtgatgctca tttttatttt tttcttttct tttagatgga gtcttgctct 1501 gttgcccagg ctggagagca gtggcacgat gttggttcac tgcaacctcc gcctcccatg 1561 ttcaagtgat tctcctgcct cagcctcctg agtagctggg attacaggtg tccaccacca 1621 tgccctgcta atttttgtat ttttagtaga gacggggttt caccatgttg gtcaggctgg 1681 tcttgaactc ctgacccgcc tcggcctccc aaagtgctgg aattgctcat ttttaatctc 1741 agcagctcat tcacagatca tacatggaaa cttatcactc acacctaagc cttctttgcc 1801 tgtcttagag atccctggtg caagaaactg taagattatt tgacacattt tctctgtctc 1861 accctaacag cctctttcta gtatttgttt taaaaaactt attttttttt tttttgagaa 1921 gttttttaga gcaagggttt ggggagacag agggatgaat aagtggagcc cagagggttt 1981 ttagggcagt aaaactactc tacatgatac tgtaatggtg gatacatgtc accaccatgc 2041 ataaaatgta caacaccaag actgaaccct agggtgaaat atggactcag gctgataatg 2101 atgtgtcagt gtaggtttat cagttgtaac aaatgtacca ctttgaggct gggagcggtg 2161 gctcatgcct gtaatcccag tactttggga gtccaaggtg ggcagatcac ctgaggtcag 2221 gagttcaaga ccagcctggc caacattgtg aaacctcgtc tctactaaaa ctacaaaaat 2281 tagctgggca tggtggcggg tgcctataat cccagctact tgggaggctg aggcaggaga 2341 atcgcttgaa ccttggaggt tgaggttgcg gtgagctgag atggtgccac tgcactccag 2401 cctggtccac agagcgagac tccatctcaa aaaaaaaaaa aagtaccact ttgggggtgg 2461 tgttgataat gggggaggct gtacatgtgt aggggtagga ggcatgtagg aaatgtctgt 2521 agctttccct cagttttgct gtaaatctta ctagtgtttg aatgccaaat ccttaagatc 2581 atatctattt cttgtcactg gcagtgagtt ctgttcttga ctttccacta agagcagtac 2641 tgatgacaac atcccgcagt attttatgag ccggagaaca ttaacatatc taaaagagta 2701 cattttcctc tggagggcca ccagcctgta aactgcaggt caaaaagctg agtgtgaaca 2761 gcattgttag gacatgtttc taagtgtatg ccaatatgtc cacagaggtt tttttagact 2821 tataaagcga gctaaagaag acttttgttc cattttctga tttttaattt atatagacat 2881 tttttcattt gaagaaagtg catatatttt taaaggaaag gtactcttaa gtctatccat 2941 ttaagaaaat attaatctcc atggagaaga aattttccat attttaaaat ttattgtgtg 3001 taggtatatt ccatatacac tctataaata aaaagcacac tggctgggcg cagtggctca 3061 tatctataat cccaatgctt tgggaggctg aggcgggcag atcacctgag gtcaggagtt 3121 tgagaccagc ctggccaaca ttgtgaaacc ctgtctctac taaagataca aaaattatct 3181 gggtgtgatg gcagacgcct atagtcccag ctactcagga ggctgaggca ggagaatcac 3241 ttgaacctag gaggtggagg ttgcagtgag ccaagatggc actactgcac tccagcctgg 3301 gcaacagagc gacactccat ctcaaaaaaa taaataaata aataaaataa aaagcacaca 3361 ctatcacaaa gaagatggtg gcaaaaataa taataaaaat agtaagtaaa taaatagcac 3421 agaagtattt acagtaaaaa attaggtctc cttccagccc ccacctgcca atcactctca 3481 ggaggcaccc actgtcttca gctacaaagc tttcagagag attttattaa tataagcaaa 3541 tacatacttt ttaaaaaagt ataaataagg cctggtgcag tggctcacgt ctgtaattcc 3601 agcactttgg gaggatgagg tggaaggatc tcttcaggcc aggagttaga gaccagcctg 3661 ggcaacataa caagaccccc atctctaaaa aaacaatcaa aaaaactaac tgggcatggt 3721 ggcatggttc tatagtccca gctactcagg aagctgagag tgagggattt cttgattcca 3781 ggacttcgag gctgtcaccc actccagctt gggtgacaga gcaagactct gtctcaaaaa 3841 aaaaaaaagt ataaacacta gcatatcata tattgccctg gacttttctt tttgatttaa 3901 catatcttgg agattcttcc atagctgtgg ataaggagtt gcctcattct ttttcagggt 3961 aagtttagta taaagggtga tatagtgggg aaattatatt taatttattt ttgccaactc 4021 agtagcagag ctgtgacaag attaatcctt agatttttgg aggttcatat caaatcattc 4081 aaagctttga catttttctc ttctttgtgg ctctattttc atcactaaaa ttccccatcc 4141 tatgcccctg cagcccccat ctgacgtttg tcacttctct agcttagtca tctgatctaa 4201 ttttgatgag tcagatgtaa ataaacccag ataatgtgtc ttttagccca aaagactaaa 4261 agataaaata aaaggaaatg cataggacac agggcagttt gttgaatggc tgagatttga 4321 atatgtgtgt attaattctt tctgaattac agctagattc tgccctcccc agctttgtat 4381 ctggagacga gggaaaatgt gatcccagtt catattatga gtgaacatct ctgactgttc 4441 taagaagtcc tattccctta gattactgaa gttcacaggg agaaagcacc cacccagata 4501 tttttggttt ttgtttgttt gtttgtttgt tgagatggag tctcactcta ttgcccaggc 4561 tagagtgcaa cggtatggtc ttggctcgct gaaacctttg cctcctggtt caagcgattc 4621 tcctacctca acctcccaag tagctaagat ttcagacata agccaccatg cccagctaat 4681 ttttgtgttt ttagtacaga cagggtttca ccacattgtt caggctgggc ttgaactcct 4741 gacctcaggc gatccacccg cctcagcctc ccgaagtgct gggattacag gcatgagcca 4801 ccgcacctgg cctcacccag atatttttca aataccattt tcgattccca ctctctttct 4861 tgaagtaagc aaggcagaca catttgccaa ggataactga gaatgtaagg gcaatccatg 4921 actgggcagc ttgtgcaggc tgtgtgctaa atgcactggg aaacatgccc tataaatagc 4981 cgttcattgt cagcatgtgt gaaaagacaa gagagcattc cgtgctatga ttcaggccta 5041 attaagtgat tgcgtctggg cacggctata aaccactagc tgcttcaact ggtaatccag 5101 tcagtaggca actgcagggg ctcgccactg actgaaggca gtggaaggtt ggcagaagga 5161 ggctgttcaa ggctgttttt gccttcacta tggcaaaaat cattttgagg cacctcatag 5221 agattccagt gcgttaccag gaagagtttg aagctcgagg tctagaagac tgcaggctgg 5281 atcatgcttt atatgcactg cctgggccaa ccatcgtgga cctgaggaaa accagggcag 5341 cgcagtctcc tccagtggac tcagcggcag agacgccacc ccgagaaggc aaatcccact 5401 ttcagatcct gctggacgtg gtccagttcc tccctgaaga catcatcatt cagaccttcg 5461 aaggctggct gctgataaaa gcacaacacg gaaccagaat ggatgagcac ggttttatct 5521 caagaagctt cacccgacag tacaaactac cagatggtgt ggaaatcaaa gatttgtctg 5581 cagtcctctg tcatgatgga attttggtgg tggaagtaaa ggatccagtt gggactaagt 5641 gacatcgtat cggttcctgt tcagatgaca tggggaagat gatggttcag ccactggtac 5701 tacgagaatg tttgtattac ccacatttga aatgatttgc tatgattttt atgaagatta 5761 aaaatatata cacagttcct ggtatgttga ggttgtcttt attattctta ctcagaaagg 5821 aaaatttgta aatatgtttg tgtggctcaa actgatacta ttcttacaac tgaaacattg 5881 aaaatacaga aggctgtatt tggatattag agaggactcc gaattgtttc ttattattcc 5941 aacaatgcca gctgcatttg taatcactga tggcaaaaga gctataccca tttaaggaat 6001 tcctatccat tttatgaaaa tcttttattt tgccaaaaag agttgtgatt cccttcactc 6061 gataagcttt tctttttaat gtattttaat taaaatgagg ttttataaat atggagtgca 6121 aaaattaaaa tacagtattt ggaaattggg tctgatatct atttatgatt tagtatagtt 6181 gttactgcct taaaggtcaa tgggaatttt cagatataaa tcttattttt aaaaagttca 6241 aatatgtacc tcattcatct ttttaaagat atactgaatc ctatctgaag tgttttgact 6301 ttttaaagat agtataagtt ctatggacac gtacaaaatg ttcatgagat atgtatttac 6361 atatcctctt gtaaattaat atgaagctta aggacaccac ttttaaaagt ttgattgctg 6421 aattcagtga gttttaatct gtgcttttta gatgctccat aaacttagat ggcaaaatgt 6481 aacacatctg ctatctctgc ataatcctta gctttaaata gcctggcagc caatggaagt 6541 tcaacacctg agcttacact gcgtgtctga gtttacacag cacatctgat gattggtgct 6601 tattatattc tcccaaacta ctgccttggc tcaaggtgga gacattggta gaggttaagg 6661 actagtgcct tcaacagctg ctctgggaca ttccaaaggt ttgctatctc attctgtata 6721 cattaagtat ttcttcagag gcagtggctg cctgcctttt accccgcact gaatgtgagc 6781 tgacaagcag cccaaggaca gtgctaagaa tagacatgga atgcagggtg tggaaaacac 6841 cagggcaaat gcagattgct gacagtatcc cagtactccc ccacgttgtt ttactgtagc 6901 tcaagttaaa atgtaaaaga catgaagcaa tagaaaaacg aatcaaacag ttctaaaagt 6961 tattttgaaa acaaatgtaa tctgagaaga atgtttactg tctaattaaa ttgaaaagat 7021 tttgcagtta tatgcatatc tgaggtttat gcctatacat ggaggtttgt gtgtccaact 7081 cagatatgaa aaattttgtt tgaccaagtg aatatcacag atcagcttgg ctgcataaca 7141 aagttaatag cagtcgttga gattccagat ctactaatat gatcagaact gggataccat 7201 ttgtctggat tatcattctt tcccagtgat tggcagaata gtgtgaaaag aaactaatgt 7261 ggtgagaaac aaaaaaaccc tctctttcgg ccttgatctt actctagatg agatcctcct 7321 cccgggaaaa ttcaggaggt gaaattccta ccatgaggag ccactgatag aaaatattct 7381 ctttaaaaat aaaattaaag taaacacatg tctaatgagc tcttgttttt acaagataaa 7441 ttttaaagtc ttatagataa gatatagata agttttaaag ataaatttta aagtcttata 7501 gccatttttt tgatttggga aatataccaa acactataaa taataaaaat catctatggt 7561 tcttctgcta ccatgaggca gctattttaa atatcttgtt caacaacagg actacataaa 7621 tacatgtatc acttttcaca aaattaggat tatatctgta tggagtttga tatcctgatt 7681 gtactggcta ctgtctgttg ccctccccac tcccaccaag tcaaaccatt ctctgccctt 7741 ctcagcccca ctctgagccc aagcaggctg accctgatgg gcca //