LOCUS NG_009490 14258 bp DNA linear PRI 13-MAR-2011 DEFINITION Homo sapiens transthyretin (TTR), RefSeqGene on chromosome 18. ACCESSION NG_009490 VERSION NG_009490.1 GI:222144284 KEYWORDS RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079096.4. This sequence is a reference standard in the RefSeqGene project. Summary: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-14258 AC079096.4 93646-107903 FEATURES Location/Qualifiers source 1..14258 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="18" /map="18q12.1" gene 5001..12258 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /note="transthyretin" /db_xref="GeneID:7276" /db_xref="HGNC:12405" /db_xref="MIM:176300" mRNA join(5001..5205,6130..6260,8354..8489,11802..12258) /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /product="transthyretin" /transcript_id="NM_000371.3" /db_xref="GI:221136767" /db_xref="GeneID:7276" /db_xref="HGNC:12405" /db_xref="MIM:176300" exon 5001..5205 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /inference="alignment:Splign:1.39.8" /number=1 STS 5020..5385 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:176279" /db_xref="UniSTS:154781" CDS join(5137..5205,6130..6260,8354..8489,11802..11909) /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /note="prealbumin, amyloidosis type I; thyroxine-binding prealbumin; ATTR" /codon_start=1 /product="transthyretin precursor" /protein_id="NP_000362.1" /db_xref="GI:4507725" /db_xref="CCDS:CCDS11899.1" /db_xref="GeneID:7276" /db_xref="HGNC:12405" /db_xref="MIM:176300" STS 5915..6329 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:181629" /db_xref="UniSTS:155316" STS 5995..6457 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:176280" /db_xref="UniSTS:154782" STS 6097..6292 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:186556" /db_xref="UniSTS:155492" exon 6130..6260 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /inference="alignment:Splign:1.39.8" /number=2 STS 6449..7680 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:192401" /db_xref="UniSTS:155715" STS 6631..6831 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="RH75505" /db_xref="UniSTS:89012" STS 6661..7313 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:217063" /db_xref="UniSTS:156226" STS 8145..8509 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:176281" /db_xref="UniSTS:154783" STS 8313..8499 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:568915" /db_xref="UniSTS:157763" STS 8313..8425 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:568923" /db_xref="UniSTS:157764" STS 8313..8377 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:568908" /db_xref="UniSTS:157762" exon 8354..8489 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /inference="alignment:Splign:1.39.8" /number=3 STS 9698..10614 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:192403" /db_xref="UniSTS:155716" STS 9732..9881 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="G29143" /db_xref="UniSTS:5979" STS 11370..11574 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="RH76196" /db_xref="UniSTS:92670" STS 11729..11984 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:186202" /db_xref="UniSTS:155479" STS 11729..11911 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:186319" /db_xref="UniSTS:155484" STS 11752..11954 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:186206" /db_xref="UniSTS:155481" STS 11799..12056 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:177915" /db_xref="UniSTS:154981" exon 11802..12258 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /inference="alignment:Splign:1.39.8" /number=4 STS 11802..12026 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="GDB:196602" /db_xref="UniSTS:155873" STS 11900..12031 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="RH11645" /db_xref="UniSTS:68166" STS 11929..12028 /gene="TTR" /gene_synonym="HsT2651; PALB; TBPA" /standard_name="D18S1032" /db_xref="UniSTS:9413" ORIGIN 1 ttatgtgttt attcaacaat ggcggaggag aggcatgcca gataaggcag acacgggcat 61 tccaaacaca agaaaggtat gtgctgcaga gaagtcagat aactttccta ggctctcctg 121 cagtccggat gaaatactct caaaaaatta gcccgggccc tttgctccaa tttttcgctt 181 acctagcaac catctaacta ttaattaaat tggtattatg gttttaacat gaatctttta 241 tgatttgctt accattaatc aaacccccga ggcttattca cctcaagggg agctgacaaa 301 gttgaattat tcaacctgca aagatccagg gcccccaaat actgtcattt ccactctccc 361 ctaaccccca ccatgaggcc cagtctcagc actcggccag cctatgccca actcggggta 421 atcagcttag acatattaat attagtgggc atttcagtat caacagatca ctgtctagca 481 gctgacaggc accctcagaa aataaaccaa gaagaaaggg tttatctata atatcaaaat 541 ttttcataga taaacctgcc cattataagg aagagggcag aagaacccta aactaagagc 601 caggcaactt gttcattaat cacagcatat tccatagaag gaggagaaat gttgtcatca 661 aattcatctt tttcacctca attaaacatc tatgctacag ctccacagtc agattgagag 721 gaaaaacagt acgtagctaa gaaaagacat agacttgtaa ctgaaatgct tcactggtgc 781 tccttttgtt ttaaggcatt ggatcttcat agctactgat cgtgcccaag cacacagtat 841 ctgcagcaac cacttaggcc tccaggaatg tggtgaccat tgaccctaat tcattcccct 901 tcatggatcc tatgtaacca tcctccaaaa agagctttcg caaactcaaa taaacacagg 961 aaaggaagac cttcttatct ttgagagtat atgtttagcc ctataaccct ctcttatcat 1021 aaattgcttc ttaggcaaga aacactggat ttttcttgta tttgtcattg ccattggttc 1081 catacaagca ttcatttaac aaataataca ttccatctcc gttttttgct ttttccttca 1141 tgcttcggcc ttggttttct ctcacctaaa acactacaag cttcttctcc cagagctctc 1201 actttgactc cagactacct acatttaatc tttaattctc taccaaaatt ttctcttatc 1261 tttatatctt tttaatttta attttatttt ttgtggatac atagtaggtg tatatattta 1321 tggggtacat gcaatgtttt aatacaggca tgcaatgtga aataaggaca tcatggagaa 1381 tggggtatcc atctcctcaa gcatttatct tttcagttac aaacaatcca attacactct 1441 ttattttaaa atatacaatt attaattata gtcactctgt tgtgctatca aatagtagat 1501 cttattcttt ctattttttg taccctctcg tctttttata ttaaaaaata atctttatct 1561 ctgtaagctt catcagtgat tttccaatga aatttaggat cttctctata ccctgaattg 1621 ccttactttc tccccacttc cttgtcttat tcaaatgcag atttcattaa tgatttccag 1681 atcaatgata gttcagaaag caagcaagtc aaagtgacca agggcatggc ctgaaaactg 1741 ttctaagaga ggaatttaca gaacaactat taaatgatgt caataggatt gtattagtcc 1801 gttttcatac ggctataaag aactgcctga gactgggtaa tttataaagg aaagaggttt 1861 aattgactca cagttcagca caactgggca ggcctcagga aacttacaat catggtagaa 1921 ggtgaagggg aagcaaagca ccttcctcac aaggcgtcag gaagaagtgc caagcaaagg 1981 gggaaaagcc ccttgtaaaa ctaccagaac ctgtgagaac tcaatcacta tcacaagaac 2041 agcatgaggg aaccgcccct cgtgattcaa ttacctccac ctggtctctc ccttgacaca 2101 tggggattat gggtgttaca attcaagatg agatttgggt ggggacacaa agcctaacca 2161 tatcaaggat caagtggtgg gttgaaacta acaggatgag atatatcaga tacaaacaca 2221 gggtcccata tttgggttaa aattcataaa tgatcaaagc acaggatgac agataatata 2281 ggtcatttta gattattgtg gccaacagat cacagtgggt agtgttatga cgaagggagg 2341 gtcacagtta ctacagttac agatggattc tgggtacaac atttgcacta aagtgccttt 2401 gccaagggag gcaacagtct cgacatcctg tggcctgatc tacttcaggg actgtgtctt 2461 gttcagagca tcacatttga agagaacttt gaccaagggg aatatgccag aaaaggaagt 2521 tcgggatgct gaggatctta ggaactatgt ctaaacaaga ttcattcaca gaagtgggaa 2581 tgtctatttg gcaaaaagaa aatactactt acatggctgt tggaagacca gcaatcacaa 2641 actcagtttt tcaaaaggct gggcagaaac acagatgaaa gaaacaggcc atgtttaaga 2701 aaagataaaa gctcacgcat gatatgccac tagagaatca cctagcctca gtgttggcgg 2761 ggaggcctgg ggagtcttga tgtctgagag tgacattctg atgatcactg tcatgtgtaa 2821 atgttggcct aaagctgcca atatttttga tttaagagaa gcaagaaatg caaattttta 2881 tgcagcatgt ctcaattttt aattttggca actattacaa aatgtttaaa gagactctgt 2941 gcagcccaaa tataacatat ctatgggctg atggcagccc agcgttgcca gttcacaggg 3001 tctacaagag atgattctta gtttcaacag ggtgcagtgc tgaaacgcgt gcacagtaga 3061 ttttgcttcg gttatgaaag aacttccaaa tatttatgat tcatagccag agaaaaggct 3121 ctctatccag gttctgaaca ataggaaatc atcaagagga tattggatga caatatatga 3181 aagatgttat ttgagaaagg attctctcct gaggcataga tgttgaacca aattctatta 3241 gttatgcttt tacagcaaga tagtggttta cagcttacaa aaggcttgta catcctctca 3301 tattaaaagt tattagaaca gtcctttgaa gtagaaaagt aggcatttct attttacaaa 3361 cgagttggcc gagtatctga gatagtagat aactcataga aggtcatccg ggaaacgggg 3421 cagcagaact gggatcgaat gactctggtc atccaactcc aaatgcaaaa gtctttctgc 3481 tgctgcttcc tagttaaact ctaagggtct aagactccat tcctagttat ggtctcaact 3541 acatttgctc attgctgtga ggggtcaacc cacctcccgg agtcctctcc tgcacattct 3601 catgttcctg aaaggctttt ctgtcccttc cactactccc tgtaagctcc tgtgcttcac 3661 aatttcttgt tgaatttttt ctaatctgac tctatcagtt atgggaatgt tccctcaatt 3721 cttagtgctc caaaccggac ttgctcttgg cttgtatttg tccaaaatat ttgtcttctc 3781 tatgttttct acatgtttgt cttataagga caaaaacctg ccttagttta tccatgaaca 3841 aagccacgca tgctagtgga cacacacaca catgcgcgtg cgcgcgcaca cacacacaca 3901 cacacataca cacagagact ttgtatgtga gtaatgaatc atcaaatcat cataatttct 3961 ggacttgtat taataagtcg gccaggagga aaagaatctg ctgtcaatca tggcttctgg 4021 ttctcacagt catctctact ttcttccagc aagtttggtt ctgtcaaaaa ccagctgtca 4081 gccttgttcc tgcatgccca atgcagaaga gtcagtaaag aagatttggt tctctgtatt 4141 tcaggggcat caatgccagg ttgaaatatg ccattctggc ccagctcagt ggctcacacg 4201 tgtaatccca gcactttgga aggccaaagc gggtggattg cttgagctca ggagttcgag 4261 accagcctgg gcaagaggct gaggtgggag gatgacctga gcccgggagg tcaaggctgc 4321 agcgagctgt gatcgtgcca ctgcactcga gccagggcgt tggagtgaga ccctgtcaaa 4381 aaaaaaaaaa aaaaggaagg aaaaaaggaa ggaaggaagg gagggaggga agatgccatt 4441 cttagattga agtggacttt atctgggcag aacacacaca cacatacaca catgcacaca 4501 cacattgtgg agaaattgct gactaagcaa agcttccaaa tgacttagtt tggctaaaat 4561 gtaggctttt aaaaatgtga gcactgccaa gggtttttcc ttgttgaccc atggatccat 4621 caagtgcaaa cattttctaa tgcactatat ttaagcctgt gcagctagat gtcattcaac 4681 atgaaataca ttattacaac ttgcatctgt ctaaaatctt gcatctaaaa tgagagacaa 4741 aaaatctata aaaatggaaa acatgcatag aaatatgtga gggaggaaaa aattaccccc 4801 aagaatgtta gtgcacgcag tcacacaggg agaagactat ttttgttttg ttttgattgt 4861 tttgttttgt tttggttgtt ttgttttggt gacctaactg gtcaaatgac ctattaagaa 4921 tatttcatag aacgaatgtt ccgatgctct aatctctcta gacaaggttc atatttgtat 4981 gggttactta ttctctcttt gttgactaag tcaataatca gaatcagcag gtttgcagtc 5041 agattggcag ggataagcag cctagctcag gagaagtgag tataaaagcc ccaggctggg 5101 agcagccatc acagaagtcc actcattctt ggcaggatgg cttctcatcg tctgctcctc 5161 ctctgccttg ctggactggt atttgtgtct gaggctggcc ctacggtgag tgtttctgtg 5221 acatcccatt cctacattta agattcacgc taaatgaagt agaagtgact ccttccagct 5281 ttgccaacca gcttttatta ctagggcaag ggtacccagc atctattttt aatataatta 5341 attcaaactt caaaaagaat gaagttccac tgagcttact gagctgggac ttgaactctg 5401 agcattctac ctcattgctt tggtgcatta ggtttgtaat atctggtacc tctgtttcct 5461 cagatagatg atagaaataa agatatgata ttaaggaagc tgttaatact gaattttcag 5521 aaaagtatcc ctccataaaa tgtatttggg ggacaaactg caggagatta tattctggcc 5581 ctatagttat tcaaaacgta tttattgatt aatctttaaa aggcttagtg aacaatattc 5641 tagtcagata tctaattctt aaatcctcta gaagaattaa ctaatactat aaaatgggtc 5701 tggatgtagt tctgacatta ttttataaca actggtaaga gggagtgact atagcaacaa 5761 ctaaaatgat ctcaggaaaa cctgtttggc cctatgtatg gtacattaca tcttttcagt 5821 aattccactc aaatggagac ttttaacaaa gcaactgttc tcaggggacc tattttctcc 5881 cttaaaattc attatacaca tccctggttg atagcagtgt gtctggaggc agaaaccatt 5941 cttgctttgg aaacaattac gtctgtgtta tactgagtag ggaagctcat taattgtcga 6001 cacttacgtt cctgataatg ggatcagtgt gtaattcttg tttcgctcca gatttctaat 6061 accacaaaga ataaatcctt tcactctgat caattttgtt aacttctcac gtgtcttctc 6121 tacacccagg gcaccggtga atccaagtgt cctctgatgg tcaaagttct agatgctgtc 6181 cgaggcagtc ctgccatcaa tgtggccgtg catgtgttca gaaaggctgc tgatgacacc 6241 tgggagccat ttgcctctgg gtaagttgcc aaagaaccct cccacaggac ttggttttat 6301 cttcccgttt gcccctcact tggtagagag aggctcacat catctgctaa agaatttaca 6361 agtagattga aaaacgtagg cagaggtcaa gtatgccctc tgaaggatgc cctctttttg 6421 ttttgcttag ctaggaagtg accaggaacc tgagcatcat ttaggggcag acagtagaga 6481 aaagaaggaa tcagaactcc tctcctctag ctgtggtttg caaccctttt gggtcacaga 6541 acactttatg taggtgatga aaagtaaaca ttctatgccc agaaaaaatg cacagataca 6601 cacacataca aaatcatata tgtgatttta ggagtttcac agattccctg gtgtccctgg 6661 gtaacaccaa agctaagtgt ccttgtctta gaattttagg aaaaggtata atgtgtatta 6721 acccattaac aaaaggaaag gaattcagaa atattattaa ccaggcatct gtctgtagtt 6781 aatatggatc acccaaaacc caaggctttt gcctaatgaa cactttgggg cacctactgt 6841 gtgcaaggct gggggctgtc aagctcagtt aaaaaaaaaa agatagaaga gatggatcca 6901 tgaggcaaag tacagcccca ggctaatccc acgatcaccc gacttcatgt ccaagagtgg 6961 cttctcacct tcattagcca gttcacaatt ttcatggagt ttttctacct gcactagcaa 7021 aaacttcaag gaaaatacat attaataaat ctaagcaaag tgaccagaag acagagcaat 7081 caggagaccc tttgcatcca gcagaagagg aactgctaag tatttacatc tccacagaga 7141 agaatttctg ttgggtttta attgaacccc aagaaccaca tgattcttca accattattg 7201 ggaagatcat tttcttaggt ctggttttaa ctggcttttt atttgggaat tcatttatgt 7261 ttatataaaa tgccaagcat aacatgaaaa gtggttacag gactattcta agggagagac 7321 agaatggaca ccaaaaatat tccaatgttc ttgtgaatct tttccttgca ccaggacaaa 7381 aaaaaaaaga agtgaaaaga agaaaggagg aggggcataa tcagagtcag taaagacaac 7441 tgctattttt atctatcgta gctgttgcag tcaaatggga agcaatttcc aacattcaac 7501 tatggagctg gtacttacat ggaaatagaa gttgcctagt gtttgttgct ggcaaagagt 7561 tatcagagag gttaaatata taaaagggaa aagagtcaga tacaggttct tcttcctact 7621 ttaggttttc cactgtgtgt gcaaatgata ctccctggtg gtgtgcagat gcctcaaagc 7681 tatcctcaca ccacaaggga gaggagcgag atcctgctgt cctggagaag tgcagagtta 7741 gaacagctgt ggccacttgc atccaatcat caatcttgaa tcacagggac tctttcttaa 7801 gtaaacatta tacctggccg ggcacggtgg ctcacgcctg taatcccagc actttgggat 7861 gccaaagtgg gcatatcatc tgaggtcagg agttcaagac cagcctggcc aacatggcaa 7921 aactccgtct ttatgaaaaa tacaaaaatt agccaggcat ggtggcaggc gcctgtaatc 7981 ccagctaatt gggaggctga ggctggagaa tcccttgaat ctaggaggca gaggttgcag 8041 tgagctgaga tcgtgccatt gcactccagc ctgggtgaca agagtaaaac tctgtctcaa 8101 aaaaaaaaaa ttatacctac attctcttct tatcagagaa aaaaatctac agtgagcttt 8161 tcaaaaagtt tttacaaact ttttgccatt taatttcagt taggagtttt ccctacttct 8221 gacttagttg aggggaaatg ttcataacat gtttataaca tgtttatgtg tgttagttgg 8281 tgggggtgta ttactttgcc atgccatttg tttcctccat gcgtaactta atccagactt 8341 tcacacctta taggaaaacc agtgagtctg gagagctgca tgggctcaca actgaggagg 8401 aatttgtaga agggatatac aaagtggaaa tagacaccaa atcttactgg aaggcacttg 8461 gcatctcccc attccatgag catgcagagg tgagtataca gaccttcgag ggttgttttg 8521 gttttggttt ttgcttttgg cattccagga aatgcacagt tttactcagt gtaccacaga 8581 aatgtcctaa ggaaggtgat gaatgaccaa aggttccctt tcctattata caagaaaaaa 8641 ttcacaacac tctgagaagc aaatttcttt ttgactttga tgaaaatcca cttagtaaca 8701 tgacttgaac ttacatgaaa ctactcatag tctattcatt ccactttata tgaatattga 8761 tgtatctgct gttgaaataa tagtttatga ggcagccctc cagaccccac gtagagtgta 8821 tgtaacaaga gatgcaccat tttatttctc gaaaacccgt aacattcttc attccaaaac 8881 acatctggct tctcggaggt ctggacaagt gattcttggc aacacatacc tatagagaca 8941 ataaaatcaa agtaataatg gcaacacaat agataacatt taccaagcat acaccatgtg 9001 gcagacacaa ttataagtgt tttccatatt taacctactt aatcctcagg aataagccac 9061 tgaggtcagt cctattatta tccccatctt atagatgaag aaaatgaggc accaggaagt 9121 caaataactt gtcaaaggtc acaagactag gaaatacaca agtagaaatg tttacaatta 9181 aggcccaggc tgggtttgcc ctcagttctg ctatgcctcg cattatgccc caggaaactt 9241 tttcccttgt gaaagccaag cttaaaaaaa gaaaagccac atttgtaacg tgctctgttc 9301 ccctgcctat ggtgaggatc ttcaaacagt tatacatgga cccagtcccc ctgccttctc 9361 cttaatttct taagtcattt gaaacagatg gctgtcatgg aaatagaatc cagacatgtt 9421 ggtcagagtt aaagatcaac taattccatc aaaaatagct cggcatgaaa gggaactatt 9481 ctctggctta gtcatggatg agactttcaa ttgctataaa gtggttcctt tattagacaa 9541 tgttaccagg gaaacaacag gggtttgttt gacttctggg gcccacaagt caacaagaga 9601 gccccatcta ccaaggagca tgtccctgac tacccctcag ccagcagcaa gacatggacc 9661 ccagtcaggg caggagcagg gtttcggcgg cgcccagcac aagacattgc ccctagagtc 9721 tcagccccta ccctcgagta atagatctgc ctacctgaga ctgttgtttg cccaagagct 9781 gggtctcagc ctgatgggaa ccatataaaa aggttcactg acatactgcc cacatgttgt 9841 tctctttcat tagatcttag cttccttgtc tgctcttcat tcttgcagta ttcattcaac 9901 aaacattaaa aaaaaaaaaa agcattctat gtgtggaaca ctctgctaga tgctgtggat 9961 ttagaaatga aaatacatcc cgacccttgg aatggaaggg aaaggactga agtaagacag 10021 attaagcagg accgtcagcc cagcttgaag cccagataaa tacggagaac aagagagagc 10081 gagtagtgag agatgagtcc caatgcctca ctttggtgac gggtgcgtgg tgggcttcat 10141 gcagcttctt ctgataaatg cctccttcag aactggtcaa ctctaccttg gccagtgacc 10201 caggtggtca tagtagattt accaagggaa aatggaaact tttattagga gctcttaggc 10261 ctcttcactt catggatttt tttttccttt ttttttgaga tggagttttg ccctgtcacc 10321 caggctggaa tgcagtggtg caatctcagc tcactgcaac ctccgcctcc caggttcaag 10381 caattctcct gcctcagcct cccgagtagc tgggactaca ggtgtgcgcc accacaccag 10441 gctaattttt gtattttttg taaagacagg ttttcaccac gttggccagg ctggtctgaa 10501 ctccagacct caggtgattc acctgtctca gcctcccaaa gtgctgggat tacaggtgtg 10561 agccaccgtg cccggctact tcatggattt ttgattacag attatgcctc ttacaatttt 10621 taagaagaat caagtgggct gaaggtcaat gtcaccataa gacaaaagac atttttatta 10681 gttgattcta gggaattggc cttaagggga gccctttctt cctaagagat tcttaggtga 10741 ttctcacttc ctcttgcccc agtattattt ttgtttttgg tatggctcac tcagatcctt 10801 ttttcctcct atccctaagt aatccgggtt tctttttccc atatttagaa caaaatgtat 10861 ttatgcagag tgtgtccaaa cctcaaccca aggcctgtat acaaaataaa tcaaattaaa 10921 cacatcttta ctgtcttcta cctctttcct gacctcaata tatcccaact tgcctcactc 10981 tgagaaccaa ggctgtccca gcacctgagt cgcagatatt ctactgattt gacagaactg 11041 tgtgactatc tggaacagca ttttgatcca caatttgccc agttacaaag cttaaatgag 11101 ctctagtgca tgcatatata tttcaaaatt ccaccatgat cttccacact ctgtattgta 11161 aatagagccc tgtaatgctt ttacttcgta tttcattgct tgttatacat aaaaatatac 11221 ttttcttctt catgttagaa aatgcaaaga ataggagggt gggggaatct ctgggcttgg 11281 agacaggaga cttgccttcc tactatggtt ccatcagaat gtagactggg acaatacaat 11341 aattcaagtc tggtttgctc atctgtaaat tgggaagaat gtttccagct ccagaatgct 11401 aaatctctaa gtctgtggtt ggcagccact attgcagcag ctcttcaatg actcaatgca 11461 gttttgcatt ctccctacct tttttttcta aaaccaataa aatagataca gcctttaggc 11521 tttctgggat ttcccttagt caagctaggg tcatcctgac tttcggcgtg aatttgcaaa 11581 acaagacctg actctgtact cctgctctaa ggactgtgca tggttccaaa ggcttagctt 11641 gccagcatat ttgagctttt tccttctgtt caaactgttc caaaatataa aagaataaaa 11701 ttaattaagt tggcactgga cttccggtgg tcagtcatgt gtgtcatctg tcacgttttt 11761 cgggctctgg tggaaatgga tctgtctgtc ttctctcata ggtggtattc acagccaacg 11821 actccggccc ccgccgctac accattgccg ccctgctgag cccctactcc tattccacca 11881 cggctgtcgt caccaatccc aaggaatgag ggacttctcc tccagtggac ctgaaggacg 11941 agggatggga tttcatgtaa ccaagagtat tccattttta ctaaagcagt gttttcacct 12001 catatgctat gttagaagtc caggcagaga caataaaaca ttcctgtgaa aggcactttt 12061 cattccactt taacttgatt ttttaaattc ccttattgtc ccttccaaaa aaaagagaat 12121 caaaatttta caaagaatca aaggaattct agaaagtatc tgggcagaac gctaggagag 12181 atccaaattt ccattgtctt gcaagcaaag cacgtattaa atatgatctg cagccattaa 12241 aaagacacat tctgtaaatg agagagcctt attttcctgt aaccttcagc aaatagcaaa 12301 agacacattc caagggccca cttctttact gtgggcattt cttttttttt ctttttttct 12361 tttttccttt tttgagacaa agtctcactc tgttgcccag gctagaatgc agtggtgtaa 12421 tctcagctca ctgcaacctc tgcttcctgg gttcaagcga ttctcctgcc tcagcctccc 12481 aagtaactgg gattacaggc gcatgccacc acgcctagct catttttgta tttttagtag 12541 agatgggatt ttgccatgtt ggctaggctg gtctacgaac tcctgacctc aggtgatcca 12601 cctgcctcag cctcccaaag tgctgggatt acaggcatga gccactacac ccggccccta 12661 ctctgggcat ttctttgatt aaagagaagg ggagctccaa caagatacac ctgcagcaac 12721 tcaggccgtc tgatcagttc aggccagatc tacactgcaa ccagccaggt caggggaaaa 12781 ccaaagaacc ccacacaccc aatttactta ggctgatcca aaatccatgt atggagaact 12841 cacatgcacc aggcactatt ttaggtgaac tgaatataaa gaataggacc cagtacctgc 12901 atttacttaa agaactcaca atcttttgag aacataactg tttcatcatg gtttggcagg 12961 aggctatggt acaaggcaca gcaagggtaa gaaggaggaa gaaaccaaca ccctacagaa 13021 atcagggaat gactctgaat aggtgtcact taatctgagt gttggtaatt tgtcagatag 13081 acaagggaaa aggtattcta ggtagagaga atacagtttg caaggcccag ccaagtgaaa 13141 caatttgata agttgagaga gcagacgacg attcagaatg ttgaagggca aaggtattga 13201 ggtgggatgg gttatgctgc tatcacaaat aaccccaaat ctcgggggct taacaaagta 13261 aaagtttagt ctcagttgtg ccaggtccaa tgtagaactc tttgctctag agactcttta 13321 gggtggcttt ccttctaatg gtgactgttt gagacagttt gatttagtct tgtggcttca 13381 aggtcactct ggtgatattt agccagcaga ctgagggaac atagtatggt attagacccc 13441 tctgtgctga agtgtcacac atgagtccca ttgacttctc actggccaga gctagttaca 13501 tgcccccatc tagatgtgct gagaaatgtg gcccctggct gggagccatt tcccagaaca 13561 actaactcta tgctctggaa gaggagcact aatctgagtt ggccaacaac catctctacc 13621 acagtagggt tgggactggt ggggcatgag gctggagtga aggttggttt tatctgccac 13681 gcgttacagc tgtgaatttg tcttgaaagc aacatgggtc cattgaaggg aaccttgaca 13741 tcagtcatgt ggctgggaca agaatagtta ccacttgccc gtaatctcca accaggattc 13801 tccaggagaa cctgagttag acacatggct taggcctaaa cctacctgag tggtctttct 13861 attttcctcc aaattcaaat ctcaaatctt gctaccctct aactggctat gttgagagag 13921 gaaaaaactt gaagagaatg cagtgtagct ttggagtttt tcacatgcac ttttcccaag 13981 atacatagca aaatcaatgt ctccaattct attaatgttg ttagcaagtc cttgttccat 14041 gcatattggt taatccatag caaattgcca tttttataga ctaaatggtc aaatattggc 14101 aatttcataa ggttcagtct attacctacc atgattgtat tggtcactaa cctgcctatt 14161 tttagaatgc tacatattca tttggctgtt gttaaatagc tatggatttt tataatcaaa 14221 acaggttgaa aatatgaatc agtttaaaac cacataca //