LOCUS       NG_009490              14258 bp    DNA     linear   PRI 13-MAR-2011
DEFINITION  Homo sapiens transthyretin (TTR), RefSeqGene on chromosome 18.
ACCESSION   NG_009490
VERSION     NG_009490.1  GI:222144284
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079096.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes transthyretin, one of the three
            prealbumins including alpha-1-antitrypsin, transthyretin and
            orosomucoid. Transthyretin is a carrier protein; it transports
            thyroid hormones in the plasma and cerebrospinal fluid, and also
            transports retinol (vitamin A) in the plasma. The protein consists
            of a tetramer of identical subunits. More than 80 different
            mutations in this gene have been reported; most mutations are
            related to amyloid deposition, affecting predominantly peripheral
            nerve and/or the heart, and a small portion of the gene mutations
            is non-amyloidogenic. The diseases caused by mutations include
            amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia,
            amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal
            amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel
            syndrome, etc. [provided by RefSeq].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14258             AC079096.4         93646-107903
FEATURES             Location/Qualifiers
     source          1..14258
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1"
     gene            5001..12258
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /note="transthyretin"
                     /db_xref="GeneID:7276"
                     /db_xref="HGNC:12405"
                     /db_xref="MIM:176300"
     mRNA            join(5001..5205,6130..6260,8354..8489,11802..12258)
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /product="transthyretin"
                     /transcript_id="NM_000371.3"
                     /db_xref="GI:221136767"
                     /db_xref="GeneID:7276"
                     /db_xref="HGNC:12405"
                     /db_xref="MIM:176300"
     exon            5001..5205
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     STS             5020..5385
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:176279"
                     /db_xref="UniSTS:154781"
     CDS             join(5137..5205,6130..6260,8354..8489,11802..11909)
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /note="prealbumin, amyloidosis type I; thyroxine-binding
                     prealbumin; ATTR"
                     /codon_start=1
                     /product="transthyretin precursor"
                     /protein_id="NP_000362.1"
                     /db_xref="GI:4507725"
                     /db_xref="CCDS:CCDS11899.1"
                     /db_xref="GeneID:7276"
                     /db_xref="HGNC:12405"
                     /db_xref="MIM:176300"
     STS             5915..6329
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:181629"
                     /db_xref="UniSTS:155316"
     STS             5995..6457
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:176280"
                     /db_xref="UniSTS:154782"
     STS             6097..6292
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:186556"
                     /db_xref="UniSTS:155492"
     exon            6130..6260
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     STS             6449..7680
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:192401"
                     /db_xref="UniSTS:155715"
     STS             6631..6831
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="RH75505"
                     /db_xref="UniSTS:89012"
     STS             6661..7313
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:217063"
                     /db_xref="UniSTS:156226"
     STS             8145..8509
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:176281"
                     /db_xref="UniSTS:154783"
     STS             8313..8499
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:568915"
                     /db_xref="UniSTS:157763"
     STS             8313..8425
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:568923"
                     /db_xref="UniSTS:157764"
     STS             8313..8377
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:568908"
                     /db_xref="UniSTS:157762"
     exon            8354..8489
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     STS             9698..10614
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:192403"
                     /db_xref="UniSTS:155716"
     STS             9732..9881
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="G29143"
                     /db_xref="UniSTS:5979"
     STS             11370..11574
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="RH76196"
                     /db_xref="UniSTS:92670"
     STS             11729..11984
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:186202"
                     /db_xref="UniSTS:155479"
     STS             11729..11911
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:186319"
                     /db_xref="UniSTS:155484"
     STS             11752..11954
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:186206"
                     /db_xref="UniSTS:155481"
     STS             11799..12056
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:177915"
                     /db_xref="UniSTS:154981"
     exon            11802..12258
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     STS             11802..12026
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="GDB:196602"
                     /db_xref="UniSTS:155873"
     STS             11900..12031
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="RH11645"
                     /db_xref="UniSTS:68166"
     STS             11929..12028
                     /gene="TTR"
                     /gene_synonym="HsT2651; PALB; TBPA"
                     /standard_name="D18S1032"
                     /db_xref="UniSTS:9413"
ORIGIN      
        1 ttatgtgttt attcaacaat ggcggaggag aggcatgcca gataaggcag acacgggcat
       61 tccaaacaca agaaaggtat gtgctgcaga gaagtcagat aactttccta ggctctcctg
      121 cagtccggat gaaatactct caaaaaatta gcccgggccc tttgctccaa tttttcgctt
      181 acctagcaac catctaacta ttaattaaat tggtattatg gttttaacat gaatctttta
      241 tgatttgctt accattaatc aaacccccga ggcttattca cctcaagggg agctgacaaa
      301 gttgaattat tcaacctgca aagatccagg gcccccaaat actgtcattt ccactctccc
      361 ctaaccccca ccatgaggcc cagtctcagc actcggccag cctatgccca actcggggta
      421 atcagcttag acatattaat attagtgggc atttcagtat caacagatca ctgtctagca
      481 gctgacaggc accctcagaa aataaaccaa gaagaaaggg tttatctata atatcaaaat
      541 ttttcataga taaacctgcc cattataagg aagagggcag aagaacccta aactaagagc
      601 caggcaactt gttcattaat cacagcatat tccatagaag gaggagaaat gttgtcatca
      661 aattcatctt tttcacctca attaaacatc tatgctacag ctccacagtc agattgagag
      721 gaaaaacagt acgtagctaa gaaaagacat agacttgtaa ctgaaatgct tcactggtgc
      781 tccttttgtt ttaaggcatt ggatcttcat agctactgat cgtgcccaag cacacagtat
      841 ctgcagcaac cacttaggcc tccaggaatg tggtgaccat tgaccctaat tcattcccct
      901 tcatggatcc tatgtaacca tcctccaaaa agagctttcg caaactcaaa taaacacagg
      961 aaaggaagac cttcttatct ttgagagtat atgtttagcc ctataaccct ctcttatcat
     1021 aaattgcttc ttaggcaaga aacactggat ttttcttgta tttgtcattg ccattggttc
     1081 catacaagca ttcatttaac aaataataca ttccatctcc gttttttgct ttttccttca
     1141 tgcttcggcc ttggttttct ctcacctaaa acactacaag cttcttctcc cagagctctc
     1201 actttgactc cagactacct acatttaatc tttaattctc taccaaaatt ttctcttatc
     1261 tttatatctt tttaatttta attttatttt ttgtggatac atagtaggtg tatatattta
     1321 tggggtacat gcaatgtttt aatacaggca tgcaatgtga aataaggaca tcatggagaa
     1381 tggggtatcc atctcctcaa gcatttatct tttcagttac aaacaatcca attacactct
     1441 ttattttaaa atatacaatt attaattata gtcactctgt tgtgctatca aatagtagat
     1501 cttattcttt ctattttttg taccctctcg tctttttata ttaaaaaata atctttatct
     1561 ctgtaagctt catcagtgat tttccaatga aatttaggat cttctctata ccctgaattg
     1621 ccttactttc tccccacttc cttgtcttat tcaaatgcag atttcattaa tgatttccag
     1681 atcaatgata gttcagaaag caagcaagtc aaagtgacca agggcatggc ctgaaaactg
     1741 ttctaagaga ggaatttaca gaacaactat taaatgatgt caataggatt gtattagtcc
     1801 gttttcatac ggctataaag aactgcctga gactgggtaa tttataaagg aaagaggttt
     1861 aattgactca cagttcagca caactgggca ggcctcagga aacttacaat catggtagaa
     1921 ggtgaagggg aagcaaagca ccttcctcac aaggcgtcag gaagaagtgc caagcaaagg
     1981 gggaaaagcc ccttgtaaaa ctaccagaac ctgtgagaac tcaatcacta tcacaagaac
     2041 agcatgaggg aaccgcccct cgtgattcaa ttacctccac ctggtctctc ccttgacaca
     2101 tggggattat gggtgttaca attcaagatg agatttgggt ggggacacaa agcctaacca
     2161 tatcaaggat caagtggtgg gttgaaacta acaggatgag atatatcaga tacaaacaca
     2221 gggtcccata tttgggttaa aattcataaa tgatcaaagc acaggatgac agataatata
     2281 ggtcatttta gattattgtg gccaacagat cacagtgggt agtgttatga cgaagggagg
     2341 gtcacagtta ctacagttac agatggattc tgggtacaac atttgcacta aagtgccttt
     2401 gccaagggag gcaacagtct cgacatcctg tggcctgatc tacttcaggg actgtgtctt
     2461 gttcagagca tcacatttga agagaacttt gaccaagggg aatatgccag aaaaggaagt
     2521 tcgggatgct gaggatctta ggaactatgt ctaaacaaga ttcattcaca gaagtgggaa
     2581 tgtctatttg gcaaaaagaa aatactactt acatggctgt tggaagacca gcaatcacaa
     2641 actcagtttt tcaaaaggct gggcagaaac acagatgaaa gaaacaggcc atgtttaaga
     2701 aaagataaaa gctcacgcat gatatgccac tagagaatca cctagcctca gtgttggcgg
     2761 ggaggcctgg ggagtcttga tgtctgagag tgacattctg atgatcactg tcatgtgtaa
     2821 atgttggcct aaagctgcca atatttttga tttaagagaa gcaagaaatg caaattttta
     2881 tgcagcatgt ctcaattttt aattttggca actattacaa aatgtttaaa gagactctgt
     2941 gcagcccaaa tataacatat ctatgggctg atggcagccc agcgttgcca gttcacaggg
     3001 tctacaagag atgattctta gtttcaacag ggtgcagtgc tgaaacgcgt gcacagtaga
     3061 ttttgcttcg gttatgaaag aacttccaaa tatttatgat tcatagccag agaaaaggct
     3121 ctctatccag gttctgaaca ataggaaatc atcaagagga tattggatga caatatatga
     3181 aagatgttat ttgagaaagg attctctcct gaggcataga tgttgaacca aattctatta
     3241 gttatgcttt tacagcaaga tagtggttta cagcttacaa aaggcttgta catcctctca
     3301 tattaaaagt tattagaaca gtcctttgaa gtagaaaagt aggcatttct attttacaaa
     3361 cgagttggcc gagtatctga gatagtagat aactcataga aggtcatccg ggaaacgggg
     3421 cagcagaact gggatcgaat gactctggtc atccaactcc aaatgcaaaa gtctttctgc
     3481 tgctgcttcc tagttaaact ctaagggtct aagactccat tcctagttat ggtctcaact
     3541 acatttgctc attgctgtga ggggtcaacc cacctcccgg agtcctctcc tgcacattct
     3601 catgttcctg aaaggctttt ctgtcccttc cactactccc tgtaagctcc tgtgcttcac
     3661 aatttcttgt tgaatttttt ctaatctgac tctatcagtt atgggaatgt tccctcaatt
     3721 cttagtgctc caaaccggac ttgctcttgg cttgtatttg tccaaaatat ttgtcttctc
     3781 tatgttttct acatgtttgt cttataagga caaaaacctg ccttagttta tccatgaaca
     3841 aagccacgca tgctagtgga cacacacaca catgcgcgtg cgcgcgcaca cacacacaca
     3901 cacacataca cacagagact ttgtatgtga gtaatgaatc atcaaatcat cataatttct
     3961 ggacttgtat taataagtcg gccaggagga aaagaatctg ctgtcaatca tggcttctgg
     4021 ttctcacagt catctctact ttcttccagc aagtttggtt ctgtcaaaaa ccagctgtca
     4081 gccttgttcc tgcatgccca atgcagaaga gtcagtaaag aagatttggt tctctgtatt
     4141 tcaggggcat caatgccagg ttgaaatatg ccattctggc ccagctcagt ggctcacacg
     4201 tgtaatccca gcactttgga aggccaaagc gggtggattg cttgagctca ggagttcgag
     4261 accagcctgg gcaagaggct gaggtgggag gatgacctga gcccgggagg tcaaggctgc
     4321 agcgagctgt gatcgtgcca ctgcactcga gccagggcgt tggagtgaga ccctgtcaaa
     4381 aaaaaaaaaa aaaaggaagg aaaaaaggaa ggaaggaagg gagggaggga agatgccatt
     4441 cttagattga agtggacttt atctgggcag aacacacaca cacatacaca catgcacaca
     4501 cacattgtgg agaaattgct gactaagcaa agcttccaaa tgacttagtt tggctaaaat
     4561 gtaggctttt aaaaatgtga gcactgccaa gggtttttcc ttgttgaccc atggatccat
     4621 caagtgcaaa cattttctaa tgcactatat ttaagcctgt gcagctagat gtcattcaac
     4681 atgaaataca ttattacaac ttgcatctgt ctaaaatctt gcatctaaaa tgagagacaa
     4741 aaaatctata aaaatggaaa acatgcatag aaatatgtga gggaggaaaa aattaccccc
     4801 aagaatgtta gtgcacgcag tcacacaggg agaagactat ttttgttttg ttttgattgt
     4861 tttgttttgt tttggttgtt ttgttttggt gacctaactg gtcaaatgac ctattaagaa
     4921 tatttcatag aacgaatgtt ccgatgctct aatctctcta gacaaggttc atatttgtat
     4981 gggttactta ttctctcttt gttgactaag tcaataatca gaatcagcag gtttgcagtc
     5041 agattggcag ggataagcag cctagctcag gagaagtgag tataaaagcc ccaggctggg
     5101 agcagccatc acagaagtcc actcattctt ggcaggatgg cttctcatcg tctgctcctc
     5161 ctctgccttg ctggactggt atttgtgtct gaggctggcc ctacggtgag tgtttctgtg
     5221 acatcccatt cctacattta agattcacgc taaatgaagt agaagtgact ccttccagct
     5281 ttgccaacca gcttttatta ctagggcaag ggtacccagc atctattttt aatataatta
     5341 attcaaactt caaaaagaat gaagttccac tgagcttact gagctgggac ttgaactctg
     5401 agcattctac ctcattgctt tggtgcatta ggtttgtaat atctggtacc tctgtttcct
     5461 cagatagatg atagaaataa agatatgata ttaaggaagc tgttaatact gaattttcag
     5521 aaaagtatcc ctccataaaa tgtatttggg ggacaaactg caggagatta tattctggcc
     5581 ctatagttat tcaaaacgta tttattgatt aatctttaaa aggcttagtg aacaatattc
     5641 tagtcagata tctaattctt aaatcctcta gaagaattaa ctaatactat aaaatgggtc
     5701 tggatgtagt tctgacatta ttttataaca actggtaaga gggagtgact atagcaacaa
     5761 ctaaaatgat ctcaggaaaa cctgtttggc cctatgtatg gtacattaca tcttttcagt
     5821 aattccactc aaatggagac ttttaacaaa gcaactgttc tcaggggacc tattttctcc
     5881 cttaaaattc attatacaca tccctggttg atagcagtgt gtctggaggc agaaaccatt
     5941 cttgctttgg aaacaattac gtctgtgtta tactgagtag ggaagctcat taattgtcga
     6001 cacttacgtt cctgataatg ggatcagtgt gtaattcttg tttcgctcca gatttctaat
     6061 accacaaaga ataaatcctt tcactctgat caattttgtt aacttctcac gtgtcttctc
     6121 tacacccagg gcaccggtga atccaagtgt cctctgatgg tcaaagttct agatgctgtc
     6181 cgaggcagtc ctgccatcaa tgtggccgtg catgtgttca gaaaggctgc tgatgacacc
     6241 tgggagccat ttgcctctgg gtaagttgcc aaagaaccct cccacaggac ttggttttat
     6301 cttcccgttt gcccctcact tggtagagag aggctcacat catctgctaa agaatttaca
     6361 agtagattga aaaacgtagg cagaggtcaa gtatgccctc tgaaggatgc cctctttttg
     6421 ttttgcttag ctaggaagtg accaggaacc tgagcatcat ttaggggcag acagtagaga
     6481 aaagaaggaa tcagaactcc tctcctctag ctgtggtttg caaccctttt gggtcacaga
     6541 acactttatg taggtgatga aaagtaaaca ttctatgccc agaaaaaatg cacagataca
     6601 cacacataca aaatcatata tgtgatttta ggagtttcac agattccctg gtgtccctgg
     6661 gtaacaccaa agctaagtgt ccttgtctta gaattttagg aaaaggtata atgtgtatta
     6721 acccattaac aaaaggaaag gaattcagaa atattattaa ccaggcatct gtctgtagtt
     6781 aatatggatc acccaaaacc caaggctttt gcctaatgaa cactttgggg cacctactgt
     6841 gtgcaaggct gggggctgtc aagctcagtt aaaaaaaaaa agatagaaga gatggatcca
     6901 tgaggcaaag tacagcccca ggctaatccc acgatcaccc gacttcatgt ccaagagtgg
     6961 cttctcacct tcattagcca gttcacaatt ttcatggagt ttttctacct gcactagcaa
     7021 aaacttcaag gaaaatacat attaataaat ctaagcaaag tgaccagaag acagagcaat
     7081 caggagaccc tttgcatcca gcagaagagg aactgctaag tatttacatc tccacagaga
     7141 agaatttctg ttgggtttta attgaacccc aagaaccaca tgattcttca accattattg
     7201 ggaagatcat tttcttaggt ctggttttaa ctggcttttt atttgggaat tcatttatgt
     7261 ttatataaaa tgccaagcat aacatgaaaa gtggttacag gactattcta agggagagac
     7321 agaatggaca ccaaaaatat tccaatgttc ttgtgaatct tttccttgca ccaggacaaa
     7381 aaaaaaaaga agtgaaaaga agaaaggagg aggggcataa tcagagtcag taaagacaac
     7441 tgctattttt atctatcgta gctgttgcag tcaaatggga agcaatttcc aacattcaac
     7501 tatggagctg gtacttacat ggaaatagaa gttgcctagt gtttgttgct ggcaaagagt
     7561 tatcagagag gttaaatata taaaagggaa aagagtcaga tacaggttct tcttcctact
     7621 ttaggttttc cactgtgtgt gcaaatgata ctccctggtg gtgtgcagat gcctcaaagc
     7681 tatcctcaca ccacaaggga gaggagcgag atcctgctgt cctggagaag tgcagagtta
     7741 gaacagctgt ggccacttgc atccaatcat caatcttgaa tcacagggac tctttcttaa
     7801 gtaaacatta tacctggccg ggcacggtgg ctcacgcctg taatcccagc actttgggat
     7861 gccaaagtgg gcatatcatc tgaggtcagg agttcaagac cagcctggcc aacatggcaa
     7921 aactccgtct ttatgaaaaa tacaaaaatt agccaggcat ggtggcaggc gcctgtaatc
     7981 ccagctaatt gggaggctga ggctggagaa tcccttgaat ctaggaggca gaggttgcag
     8041 tgagctgaga tcgtgccatt gcactccagc ctgggtgaca agagtaaaac tctgtctcaa
     8101 aaaaaaaaaa ttatacctac attctcttct tatcagagaa aaaaatctac agtgagcttt
     8161 tcaaaaagtt tttacaaact ttttgccatt taatttcagt taggagtttt ccctacttct
     8221 gacttagttg aggggaaatg ttcataacat gtttataaca tgtttatgtg tgttagttgg
     8281 tgggggtgta ttactttgcc atgccatttg tttcctccat gcgtaactta atccagactt
     8341 tcacacctta taggaaaacc agtgagtctg gagagctgca tgggctcaca actgaggagg
     8401 aatttgtaga agggatatac aaagtggaaa tagacaccaa atcttactgg aaggcacttg
     8461 gcatctcccc attccatgag catgcagagg tgagtataca gaccttcgag ggttgttttg
     8521 gttttggttt ttgcttttgg cattccagga aatgcacagt tttactcagt gtaccacaga
     8581 aatgtcctaa ggaaggtgat gaatgaccaa aggttccctt tcctattata caagaaaaaa
     8641 ttcacaacac tctgagaagc aaatttcttt ttgactttga tgaaaatcca cttagtaaca
     8701 tgacttgaac ttacatgaaa ctactcatag tctattcatt ccactttata tgaatattga
     8761 tgtatctgct gttgaaataa tagtttatga ggcagccctc cagaccccac gtagagtgta
     8821 tgtaacaaga gatgcaccat tttatttctc gaaaacccgt aacattcttc attccaaaac
     8881 acatctggct tctcggaggt ctggacaagt gattcttggc aacacatacc tatagagaca
     8941 ataaaatcaa agtaataatg gcaacacaat agataacatt taccaagcat acaccatgtg
     9001 gcagacacaa ttataagtgt tttccatatt taacctactt aatcctcagg aataagccac
     9061 tgaggtcagt cctattatta tccccatctt atagatgaag aaaatgaggc accaggaagt
     9121 caaataactt gtcaaaggtc acaagactag gaaatacaca agtagaaatg tttacaatta
     9181 aggcccaggc tgggtttgcc ctcagttctg ctatgcctcg cattatgccc caggaaactt
     9241 tttcccttgt gaaagccaag cttaaaaaaa gaaaagccac atttgtaacg tgctctgttc
     9301 ccctgcctat ggtgaggatc ttcaaacagt tatacatgga cccagtcccc ctgccttctc
     9361 cttaatttct taagtcattt gaaacagatg gctgtcatgg aaatagaatc cagacatgtt
     9421 ggtcagagtt aaagatcaac taattccatc aaaaatagct cggcatgaaa gggaactatt
     9481 ctctggctta gtcatggatg agactttcaa ttgctataaa gtggttcctt tattagacaa
     9541 tgttaccagg gaaacaacag gggtttgttt gacttctggg gcccacaagt caacaagaga
     9601 gccccatcta ccaaggagca tgtccctgac tacccctcag ccagcagcaa gacatggacc
     9661 ccagtcaggg caggagcagg gtttcggcgg cgcccagcac aagacattgc ccctagagtc
     9721 tcagccccta ccctcgagta atagatctgc ctacctgaga ctgttgtttg cccaagagct
     9781 gggtctcagc ctgatgggaa ccatataaaa aggttcactg acatactgcc cacatgttgt
     9841 tctctttcat tagatcttag cttccttgtc tgctcttcat tcttgcagta ttcattcaac
     9901 aaacattaaa aaaaaaaaaa agcattctat gtgtggaaca ctctgctaga tgctgtggat
     9961 ttagaaatga aaatacatcc cgacccttgg aatggaaggg aaaggactga agtaagacag
    10021 attaagcagg accgtcagcc cagcttgaag cccagataaa tacggagaac aagagagagc
    10081 gagtagtgag agatgagtcc caatgcctca ctttggtgac gggtgcgtgg tgggcttcat
    10141 gcagcttctt ctgataaatg cctccttcag aactggtcaa ctctaccttg gccagtgacc
    10201 caggtggtca tagtagattt accaagggaa aatggaaact tttattagga gctcttaggc
    10261 ctcttcactt catggatttt tttttccttt ttttttgaga tggagttttg ccctgtcacc
    10321 caggctggaa tgcagtggtg caatctcagc tcactgcaac ctccgcctcc caggttcaag
    10381 caattctcct gcctcagcct cccgagtagc tgggactaca ggtgtgcgcc accacaccag
    10441 gctaattttt gtattttttg taaagacagg ttttcaccac gttggccagg ctggtctgaa
    10501 ctccagacct caggtgattc acctgtctca gcctcccaaa gtgctgggat tacaggtgtg
    10561 agccaccgtg cccggctact tcatggattt ttgattacag attatgcctc ttacaatttt
    10621 taagaagaat caagtgggct gaaggtcaat gtcaccataa gacaaaagac atttttatta
    10681 gttgattcta gggaattggc cttaagggga gccctttctt cctaagagat tcttaggtga
    10741 ttctcacttc ctcttgcccc agtattattt ttgtttttgg tatggctcac tcagatcctt
    10801 ttttcctcct atccctaagt aatccgggtt tctttttccc atatttagaa caaaatgtat
    10861 ttatgcagag tgtgtccaaa cctcaaccca aggcctgtat acaaaataaa tcaaattaaa
    10921 cacatcttta ctgtcttcta cctctttcct gacctcaata tatcccaact tgcctcactc
    10981 tgagaaccaa ggctgtccca gcacctgagt cgcagatatt ctactgattt gacagaactg
    11041 tgtgactatc tggaacagca ttttgatcca caatttgccc agttacaaag cttaaatgag
    11101 ctctagtgca tgcatatata tttcaaaatt ccaccatgat cttccacact ctgtattgta
    11161 aatagagccc tgtaatgctt ttacttcgta tttcattgct tgttatacat aaaaatatac
    11221 ttttcttctt catgttagaa aatgcaaaga ataggagggt gggggaatct ctgggcttgg
    11281 agacaggaga cttgccttcc tactatggtt ccatcagaat gtagactggg acaatacaat
    11341 aattcaagtc tggtttgctc atctgtaaat tgggaagaat gtttccagct ccagaatgct
    11401 aaatctctaa gtctgtggtt ggcagccact attgcagcag ctcttcaatg actcaatgca
    11461 gttttgcatt ctccctacct tttttttcta aaaccaataa aatagataca gcctttaggc
    11521 tttctgggat ttcccttagt caagctaggg tcatcctgac tttcggcgtg aatttgcaaa
    11581 acaagacctg actctgtact cctgctctaa ggactgtgca tggttccaaa ggcttagctt
    11641 gccagcatat ttgagctttt tccttctgtt caaactgttc caaaatataa aagaataaaa
    11701 ttaattaagt tggcactgga cttccggtgg tcagtcatgt gtgtcatctg tcacgttttt
    11761 cgggctctgg tggaaatgga tctgtctgtc ttctctcata ggtggtattc acagccaacg
    11821 actccggccc ccgccgctac accattgccg ccctgctgag cccctactcc tattccacca
    11881 cggctgtcgt caccaatccc aaggaatgag ggacttctcc tccagtggac ctgaaggacg
    11941 agggatggga tttcatgtaa ccaagagtat tccattttta ctaaagcagt gttttcacct
    12001 catatgctat gttagaagtc caggcagaga caataaaaca ttcctgtgaa aggcactttt
    12061 cattccactt taacttgatt ttttaaattc ccttattgtc ccttccaaaa aaaagagaat
    12121 caaaatttta caaagaatca aaggaattct agaaagtatc tgggcagaac gctaggagag
    12181 atccaaattt ccattgtctt gcaagcaaag cacgtattaa atatgatctg cagccattaa
    12241 aaagacacat tctgtaaatg agagagcctt attttcctgt aaccttcagc aaatagcaaa
    12301 agacacattc caagggccca cttctttact gtgggcattt cttttttttt ctttttttct
    12361 tttttccttt tttgagacaa agtctcactc tgttgcccag gctagaatgc agtggtgtaa
    12421 tctcagctca ctgcaacctc tgcttcctgg gttcaagcga ttctcctgcc tcagcctccc
    12481 aagtaactgg gattacaggc gcatgccacc acgcctagct catttttgta tttttagtag
    12541 agatgggatt ttgccatgtt ggctaggctg gtctacgaac tcctgacctc aggtgatcca
    12601 cctgcctcag cctcccaaag tgctgggatt acaggcatga gccactacac ccggccccta
    12661 ctctgggcat ttctttgatt aaagagaagg ggagctccaa caagatacac ctgcagcaac
    12721 tcaggccgtc tgatcagttc aggccagatc tacactgcaa ccagccaggt caggggaaaa
    12781 ccaaagaacc ccacacaccc aatttactta ggctgatcca aaatccatgt atggagaact
    12841 cacatgcacc aggcactatt ttaggtgaac tgaatataaa gaataggacc cagtacctgc
    12901 atttacttaa agaactcaca atcttttgag aacataactg tttcatcatg gtttggcagg
    12961 aggctatggt acaaggcaca gcaagggtaa gaaggaggaa gaaaccaaca ccctacagaa
    13021 atcagggaat gactctgaat aggtgtcact taatctgagt gttggtaatt tgtcagatag
    13081 acaagggaaa aggtattcta ggtagagaga atacagtttg caaggcccag ccaagtgaaa
    13141 caatttgata agttgagaga gcagacgacg attcagaatg ttgaagggca aaggtattga
    13201 ggtgggatgg gttatgctgc tatcacaaat aaccccaaat ctcgggggct taacaaagta
    13261 aaagtttagt ctcagttgtg ccaggtccaa tgtagaactc tttgctctag agactcttta
    13321 gggtggcttt ccttctaatg gtgactgttt gagacagttt gatttagtct tgtggcttca
    13381 aggtcactct ggtgatattt agccagcaga ctgagggaac atagtatggt attagacccc
    13441 tctgtgctga agtgtcacac atgagtccca ttgacttctc actggccaga gctagttaca
    13501 tgcccccatc tagatgtgct gagaaatgtg gcccctggct gggagccatt tcccagaaca
    13561 actaactcta tgctctggaa gaggagcact aatctgagtt ggccaacaac catctctacc
    13621 acagtagggt tgggactggt ggggcatgag gctggagtga aggttggttt tatctgccac
    13681 gcgttacagc tgtgaatttg tcttgaaagc aacatgggtc cattgaaggg aaccttgaca
    13741 tcagtcatgt ggctgggaca agaatagtta ccacttgccc gtaatctcca accaggattc
    13801 tccaggagaa cctgagttag acacatggct taggcctaaa cctacctgag tggtctttct
    13861 attttcctcc aaattcaaat ctcaaatctt gctaccctct aactggctat gttgagagag
    13921 gaaaaaactt gaagagaatg cagtgtagct ttggagtttt tcacatgcac ttttcccaag
    13981 atacatagca aaatcaatgt ctccaattct attaatgttg ttagcaagtc cttgttccat
    14041 gcatattggt taatccatag caaattgcca tttttataga ctaaatggtc aaatattggc
    14101 aatttcataa ggttcagtct attacctacc atgattgtat tggtcactaa cctgcctatt
    14161 tttagaatgc tacatattca tttggctgtt gttaaatagc tatggatttt tataatcaaa
    14221 acaggttgaa aatatgaatc agtttaaaac cacataca
//

