LOCUS       NG_011621               9678 bp    DNA     linear   PRI 23-MAY-2010
DEFINITION  Homo sapiens troponin I type 2 (skeletal, fast) (TNNI2), RefSeqGene
            on chromosome 11.
ACCESSION   NG_011621
VERSION     NG_011621.1  GI:225543376
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Johan den Dunnen. The reference sequence was
            derived from AC051649.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a fast-twitch skeletal muscle protein, a
            member of the troponin I gene family, and a component of the
            troponin complex including troponin T, troponin C and troponin I
            subunits. The troponin complex, along with tropomyosin, is
            responsible for the calcium-dependent regulation of striated muscle
            contraction. Mouse studies show that this component is also present
            in vascular smooth muscle and may play a role in regulation of
            smooth muscle function. In addition to muscle tissues, this protein
            is found in corneal epithelium, cartilage where it is an inhibitor
            of angiogenesis to inhibit tumor growth and metastasis, and mammary
            gland where it functions as a co-activator of estrogen
            receptor-related receptor alpha. This protein also suppresses tumor
            growth in human ovarian carcinoma. Mutations in this gene cause
            myopathy and distal arthrogryposis type 2B. Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9678              AC051649.21        154337-164014       c
FEATURES             Location/Qualifiers
     source          1..9678
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     STS             67..1630
                     /standard_name="stSG548512"
                     /db_xref="UniSTS:461627"
     STS             106..372
                     /standard_name="REN115906"
                     /db_xref="UniSTS:440701"
     STS             405..647
                     /standard_name="REN115907"
                     /db_xref="UniSTS:440702"
     gene            442..3518
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /note="synaptotagmin VIII"
                     /db_xref="GeneID:90019"
                     /db_xref="HGNC:19264"
                     /db_xref="MIM:607719"
     mRNA            join(442..599,1092..1197,1294..1457,1884..1982,2124..2282,
                     2423..2590,2754..2859,2955..3088,3190..3518)
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /product="synaptotagmin VIII"
                     /transcript_id="NM_138567.3"
                     /db_xref="GI:94536845"
                     /db_xref="GeneID:90019"
                     /db_xref="HGNC:19264"
                     /db_xref="MIM:607719"
     CDS             join(570..599,1092..1197,1294..1457,1884..1982,2124..2282,
                     2423..2590,2754..2859,2955..3088,3190..3429)
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /exception="mismatches in translation"
                     /note="synaptotagmin 8; sytVIII; synaptotagmin-8"
                     /codon_start=1
                     /product="synaptotagmin-8"
                     /protein_id="NP_612634.3"
                     /db_xref="GI:94536846"
                     /db_xref="CCDS:CCDS7726.2"
                     /db_xref="GeneID:90019"
                     /db_xref="HGNC:19264"
                     /db_xref="MIM:607719"
     STS             707..942
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115908"
                     /db_xref="UniSTS:440703"
     STS             731..1409
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="ECD07572"
                     /db_xref="UniSTS:288623"
     STS             920..1179
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115909"
                     /db_xref="UniSTS:440704"
     STS             1155..1413
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115910"
                     /db_xref="UniSTS:440705"
     STS             1395..1619
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115911"
                     /db_xref="UniSTS:440706"
     STS             1496..2241
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="ECD05108"
                     /db_xref="UniSTS:286174"
     STS             1600..1851
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115912"
                     /db_xref="UniSTS:440707"
     STS             1611..3158
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="stSG548513"
                     /db_xref="UniSTS:461628"
     STS             1963..2235
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115913"
                     /db_xref="UniSTS:440708"
     STS             2211..2480
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115914"
                     /db_xref="UniSTS:440709"
     STS             2455..3184
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="ECD05694"
                     /db_xref="UniSTS:286756"
     STS             2541..2790
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115915"
                     /db_xref="UniSTS:440710"
     STS             2766..3006
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115916"
                     /db_xref="UniSTS:440711"
     STS             2992..3255
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115917"
                     /db_xref="UniSTS:440712"
     STS             3139..4733
                     /standard_name="stSG548514"
                     /db_xref="UniSTS:461629"
     STS             3236..3510
                     /gene="SYT8"
                     /gene_synonym="DKFZp434K0322"
                     /standard_name="REN115918"
                     /db_xref="UniSTS:440713"
     STS             3421..4175
                     /standard_name="ECD04778"
                     /db_xref="UniSTS:285849"
     STS             3494..3762
                     /standard_name="REN115919"
                     /db_xref="UniSTS:440714"
     STS             3789..4019
                     /standard_name="REN115920"
                     /db_xref="UniSTS:440715"
     STS             4006..4234
                     /standard_name="REN115921"
                     /db_xref="UniSTS:440716"
     STS             4215..5041
                     /standard_name="ECD02555"
                     /db_xref="UniSTS:283650"
     STS             4255..4525
                     /standard_name="REN115922"
                     /db_xref="UniSTS:440717"
     STS             4510..4751
                     /standard_name="REN115923"
                     /db_xref="UniSTS:440718"
     STS             4762..5034
                     /standard_name="REN115924"
                     /db_xref="UniSTS:440719"
     gene            5001..7678
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /note="troponin I type 2 (skeletal, fast)"
                     /db_xref="GeneID:7136"
                     /db_xref="HGNC:11946"
                     /db_xref="MIM:191043"
     mRNA            join(5001..5031,5673..5702,5847..5853,6401..6442,
                     6526..6654,6817..6906,7029..7205,7454..7678)
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /product="troponin I type 2 (skeletal, fast)"
                     /transcript_id="NM_003282.3"
                     /db_xref="GI:224967058"
                     /db_xref="GeneID:7136"
                     /db_xref="HGNC:11946"
                     /db_xref="MIM:191043"
     exon            5001..5031
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     STS             5014..5238
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="REN115925"
                     /db_xref="UniSTS:440720"
     STS             5199..6014
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="ECD02854"
                     /db_xref="UniSTS:283947"
     STS             5217..5481
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="REN115926"
                     /db_xref="UniSTS:440721"
     STS             5457..5714
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="REN115927"
                     /db_xref="UniSTS:440722"
     exon            5487..5525
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            5673..5702
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     CDS             join(5695..5702,5847..5853,6401..6442,6526..6654,
                     6817..6906,7029..7205,7454..7549)
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /note="isoform 1 is encoded by transcript variant 1;
                     troponin I, fast-twitch skeletal muscle isoform; troponin
                     I, skeletal, fast; troponin I fast twitch 2; troponin I,
                     fast-twitch isoform; fast-twitch skeletal muscle troponin
                     I; troponin I, fast skeletal muscle"
                     /codon_start=1
                     /product="troponin I, fast skeletal muscle isoform 1"
                     /protein_id="NP_003273.1"
                     /db_xref="GI:4507621"
                     /db_xref="CCDS:CCDS31333.1"
                     /db_xref="GeneID:7136"
                     /db_xref="HGNC:11946"
                     /db_xref="MIM:191043"
     STS             5789..6014
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="REN115928"
                     /db_xref="UniSTS:440723"
     exon            5847..5853
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     STS             6000..6225
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="REN115929"
                     /db_xref="UniSTS:440724"
     STS             6067..6896
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="ECD02458"
                     /db_xref="UniSTS:283556"
     exon            6200..6236
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     STS             6206..6457
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="REN115930"
                     /db_xref="UniSTS:440725"
     exon            6401..6442
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     STS             6433..6659
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="REN115931"
                     /db_xref="UniSTS:440726"
     exon            6526..6654
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /inference="alignment:Splign:1.39.8"
                     /number=7
     STS             6809..7052
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="REN115932"
                     /db_xref="UniSTS:440727"
     exon            6817..6906
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /inference="alignment:Splign:1.39.8"
                     /number=8
     STS             6819..7136
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="PMC15822P2"
                     /db_xref="UniSTS:271435"
     STS             7025..7661
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="ECD09150"
                     /db_xref="UniSTS:290195"
     exon            7029..7205
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /inference="alignment:Splign:1.39.8"
                     /number=9
     STS             7144..7380
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="REN115933"
                     /db_xref="UniSTS:440728"
     STS             7370..7613
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /standard_name="REN115934"
                     /db_xref="UniSTS:440729"
     exon            7454..7678
                     /gene="TNNI2"
                     /gene_synonym="AMCD2B; DA2B; FSSV; fsTnI"
                     /inference="alignment:Splign:1.39.8"
                     /number=10
     STS             7474..8920
                     /standard_name="stSG548517"
                     /db_xref="UniSTS:461630"
     STS             7590..7819
                     /standard_name="REN115935"
                     /db_xref="UniSTS:440730"
     STS             7799..8032
                     /standard_name="REN115936"
                     /db_xref="UniSTS:440731"
     STS             8009..8260
                     /standard_name="REN115937"
                     /db_xref="UniSTS:440732"
     STS             8147..8778
                     /standard_name="ECD09358"
                     /db_xref="UniSTS:290402"
     STS             8238..8480
                     /standard_name="REN115938"
                     /db_xref="UniSTS:440733"
     STS             8460..8713
                     /standard_name="REN115939"
                     /db_xref="UniSTS:440734"
     STS             8760..8988
                     /standard_name="REN115940"
                     /db_xref="UniSTS:440735"
     STS             8887..9453
                     /standard_name="ECD11644"
                     /db_xref="UniSTS:292680"
     STS             8965..9205
                     /standard_name="REN115941"
                     /db_xref="UniSTS:440736"
     STS             9183..9452
                     /standard_name="REN115942"
                     /db_xref="UniSTS:440737"
ORIGIN      
        1 gacttggaca tggcaagagg ggtcccaggc tcttgtgggc aaagcagggg aggcgccaat
       61 gtggaggaac agagtctcct ggctggctgc tgctctctgg agcgggtgga gtcagggaag
      121 agctgagctg gggagtcacc ctgggcctgg ggtcaccgta ggccccatgt agcaccctgg
      181 ttcccctgcc tgtaggtgac aggagccagc ccagccaggt gtgctccctc cccaggccct
      241 aggcaggcgg gtacaggggc cagcagctgc gcccgcccca ccttccttcc cacccacatg
      301 ccgaagggtg gccaggcagg caggtggacg agtccaggca gcggctgagt cagtgtgtgt
      361 ggaatgttct ggccgctccc agctgcaccc tgcccctacc tgccaccacc tcaccttcat
      421 cctcaggcgc tgcggccctg agcccctgcc aggaatgcac ctttagccca ggcctgctca
      481 gtgagctccg ccgacagcca gccctgctcc tcccgccatg accctgcaga cccctctggg
      541 cttccaagtt cctgggggct gcagtgaaca tgctccacct gcatggctgg caaaccatgg
      601 tgggccccag ctgtggtgcg tgctggggta gaggcaagga agtgatggga ccgcagagat
      661 gagaccccca gggatgagat gggaccccca ggcagggccc agggtccagg gcccaggaga
      721 gagaagcagg gagggagaga gcttcctggt ggaggacgca tcctacagtg ggggcaaggg
      781 tgctctgagg tccggtgaag gcagggacta ggctgcccag gccctgcctg cttggctggg
      841 gctgggggct gctgggaggt ggctgggagg ctgggcctgg gcagctaagc tggagctttg
      901 gccagggtcc agagcctccc tcccttcagc ttcctgctgc acagaaccct cgcccctggc
      961 caccccgtgc tgcctccttg ccctggcaga cccagcactg gctgctgcta gtcagatggg
     1021 gtagcgggca ggggccggag gggccaccct cccagctgac ccagcctcct gggccgcttc
     1081 ttccaaacca gcagggtaga aagatggggc acccaccagt ctctcccagt gccccggccc
     1141 cagctggcac cacagctata cctgggctta ttccagacct tgtcgccggg accccctgtg
     1201 agttgtggga ttcccaagag gggtgtgggg ataacccagc caagtggggg ctgcagctgt
     1261 ccacagatgc actcagcctg gcctctaccc cagggccccg ctgggctctc attgccggcg
     1321 cccttgccgc gggcgtcctc ctcgtctcct gcctcctctg tgctgcctgc tgctgctgcc
     1381 gccgccacag gaagaagccc agggacaagg agtccgtggg tctgggcagt gcccgcggca
     1441 ccaccaccac ccacctggtg aggagcggct ccttgctcac tcagtccaga gagggcttga
     1501 aatccaggct ccagagccca gggcagcgag gcgagttcag ccccagggat ggtttaaccc
     1561 ccacagaggc agggcgttga ggaccttcct ggcagggaaa gtgggtgaac agaggtgaga
     1621 aggaggccat gcaacagggg ctgccccatg ggcccgaggg agccacagcg ggttcttgag
     1681 gaaggcaggg ggtaccccag atgccacgtt ttgggtgggt ttggccggtc tcacagagcg
     1741 aagccgacga tttgtgcctg ttgggtggcc tggcctggag gcggggggtc ttgacccatg
     1801 tcatgcaagg gctgcccggg agcccagggc tctgatgagg catgatgtca gcaccacctg
     1861 ccccttgtcc caactcactc caggtgcaac ctgatgtgga tggcctggag tccagcccgg
     1921 gggatgctca gcaatggggg tgcctgcagc tctccctgga gttcgacttt ggaagccagg
     1981 aggtgaaggg ccccgctgcg caggaccagc ggttctgcga gtttccggaa agggtgacgg
     2041 gggaagggca gaccccatgc cctgggtggt ggggagctga cagggcaggg gcccttggct
     2101 gagcccaccc cgctggctcc cagatcaggg tgggcctgag gcaggcagcc gacctgaggc
     2161 ctgggggcac cgtggacccc tatgcccggg tcagcgtctc cacccaggcc ggacacagac
     2221 atgagacaaa agtgcaccga ggcacgctct gccccgtgtt tgacgagacc tgctgcttcc
     2281 acgtgagtca gggatggtcg gctgggtggg cctggacggc tggatgggcc tgggctgggt
     2341 gggcctgggc agctgggtgg gcctgggcag ctgggtgggc ctgagctagg gcagcagggc
     2401 ctggctcacg ccgctgcctc agatcccgca ggcggagctg ccaggggcca ccctgcaggt
     2461 gcagcttttc aacttcaagc gcttctcggg gcatgagccc ctgggtgagc tccgtctgcc
     2521 actgggcacc gtggatctgc agcatgttct ggagcactgg tacctgctgg gcccgccggc
     2581 tgccactcag gtgaggtgct ggtcaccagg ccacagccca aggcagagct ggcagggacc
     2641 ctgccctatg ggccatcgga aagacaggcc tgatgggcag cattttcggg ggtctgagcc
     2701 ccaactcggc cagaatcacc ctcccgggct gaagcccctc ttgctgccca cagcccgagc
     2761 aggtcgggga gctgtgcttc tctctccggt acgtgcccag ctcaggccgg ctgaccgtgg
     2821 tggtgctgga ggctcgaggc ctgcgtccag gacttgcagg tgagggtcac acctgcccac
     2881 gttgttgtac agaggggggg cccgtgctca gccccgagcc ctgggatgcc ccttcggcaa
     2941 ccttgccctc ccagagccct acgtgaaggt ccagctcatg ctgaaccaga ggaagtggaa
     3001 gaagagaaag acagccacca aaaagggcac ggcggccccc tacttcaatg aggccttcac
     3061 cttcctggtg cccttcagcc aggtccaggt gggccaccgg gaggcagggg cagagcgaga
     3121 cccagtgcca gaccacgatg actgtggtct ttctccccca actccaacct ctggcctgtc
     3181 tctgcacaga atgtggacct ggtgctggct gtctgggacc gcagcctgcc gctccgaact
     3241 gagcccgtag gcaaggtgca cctgggtgcc cgggcctcgg ggcagcccct gcagcactgg
     3301 gcagacatgc tggcccacgc ccggcggccc attgcccagc ggcaccccct gcggccagcc
     3361 agggaggtgg accgcatgct ggccctgcag ccccgccttc gcctgcgcct gcccttgccc
     3421 cactcctgaa tgcaccacat gcctctgtct ccccgctgag cccaggcact tgcccaggcc
     3481 gccctgcagg accactgcaa taaacgcctt ctcctgccac tgtgtgtccg gctggagcct
     3541 ggaggggatg cagaaatagg gcccgggccc gctcaccagg gtcccctgac aaggacgggg
     3601 gaggggctcc tctccagact cagccaggcc ctgaggcctc tgaccggtcc ctgcttgacc
     3661 ctcgggtagg ggtggggaac ctccccgggg agcacagatc tcccctctcc gggccgcctg
     3721 ggaagaccgg ggaggtgggg gccagagagt cgggaccaca tgggatgggg cgggctagag
     3781 ccagccctgt agggacagag tgggcaatgg tgtctggggg ctggtgagca tggagggagg
     3841 acccccaaca cctcagagac ctgtgctgca gggccttccc tgcatgagca gcagggggca
     3901 gcagatgcct tcggaagccg ctggggcctt taggggctca gtcctggccg gatgcccctc
     3961 ccagtcccca cacatctggg ctgccttagc ggctggggcc tccacgctgc tgtctcctct
     4021 gatcctcccc acggggctgc gaagccggca gggctggggc caagagcccc cactccgaga
     4081 gggtgccaag tcacggtcca ggggacctct gcagggcggg ggcctggggg ctgggggggc
     4141 gatggcctcg ggcctgggtg aaaagggcaa tgccaggcct gcccgggcag ccaggagggc
     4201 cccaagcccc cacgggtgtg agaggctccc aatgcaggtg gcgccattct ccttaggttg
     4261 aaggatgtgt tccaagtcgc ccggcaaggg gactgcagca gggcgttctg ggcaggcggg
     4321 aggggcccag aggcacgtgc ggcgtgcccc tcactcctgg tcctgctccc caggcaggaa
     4381 gatagcatca cgcagggagg gggcagcccc cagccctcgg ccactgtggc agggcccaga
     4441 aggccacatc tggaggtcca ggcctcaccc cagaagccag gcttgcagaa gggggtcagg
     4501 cctgggctga agtgggaaac ccattgcagg ggctgagccg gggagctggc cccgcaggga
     4561 gaggctgtgg ctgtcgccag caagcagcca ggttggtgga ctggacgctg acctcgggtg
     4621 agatgggctg aggcgaggtg tggatactcg cagctacccc tcagctgacc cgagctgtgt
     4681 gcccggctga ggccacaggc aaagccaggg acactgtcct caggctcctt acgagaacga
     4741 cagaggcatc tccagcgcgt caccgagccc taaatagagt agcccagcca cggcaccccc
     4801 caccaagact tcttggactg ggcggcagca cgcggccagg ccaggcggcc ggacaggtgg
     4861 ggaggtctct gtggctctcc acgcccccat tggtctgagg aggactctat gccctttctg
     4921 agcaggggcc cagcctgggg gaggccattt atacccctcc ccctgggccc accagcccaa
     4981 ctcgccgctg ccggcctgac ctcgctccca gccctgctgc ccagattcta ggtgaggccc
     5041 agcccggccc gccgaggccg ggggacaggg cgtggctcga gctggtttga gggaggactt
     5101 cctggggcgg gggtctgggg gcctggggga tgccaccagc agcccccttt ggggcctgca
     5161 cgggtccggg agtgagaagg agaggctttg gggaggcagc tgtagcgaga ggcaggtatt
     5221 agacactccc tgaccaccag gcttcacctc tggggaccct ggaaggagag tttaggggtc
     5281 aagaagcccc agaacctgag cccccaggcc aaactgagga gggatttctt ccatgcactt
     5341 aggcccaaag ccaaagagag agggttaaaa ataacagcgt cactcaggcg gccacctgcg
     5401 ctggcccatc ccaccctccc tcggggacag ctgcagctcc tcaggctatg cctgggacat
     5461 tttgggaaca ctttctcctc ttacttctca ccctggggaa ttccaagaca ttgtccttga
     5521 aggaggtgag agtaggggga ggaggtgaga gtagggggtg ggcgggaggg ggctgtcatc
     5581 aggagccctg aacccctcac cacctacctg atgggcacag gcatcacggt ggcaagggcc
     5641 tggccaacac ctctgtcttc ctctccccac aggctccaag ctcaggacct caggatggga
     5701 gagtaagtgg tacccctgta cccccataca gtgaccctgc ccacctcctg ccctgtccac
     5761 cccatcacac actccgaccc cgccagccat ggccctaacc tctgtcttct ctccccgtcc
     5821 tgcctgcgtc ctccctccct ggacagtgag gaggtaagta gttgctgggg gctcaaaaca
     5881 tgacgaggag ggggctcccc caactcagca taggtcatag gtcacagcct caaggcccta
     5941 aggcccagag aagatggcct ggccctcccc gctggcaaaa gtgccccacc cacccaccaa
     6001 gacgctgctg aaagagagga agtggctgcc ccaagccttc tggggcaggg gaagtgtggc
     6061 tgtggcctgg tcacagggga atcacttctt ctttctgatt cctgcacttc ccgcccccac
     6121 ctcaccggcc gacctgcccc caactggccc tcctctcccc cagcctctgg cctcccagca
     6181 ccatgtgcca cctggcaaag tgtcacacac cacacagcac catgtcccag tgcaaggtct
     6241 ggggccaggg aggcccagcc tgcccatcat ggcctcagga gcccccaggc tctgctggtc
     6301 ccggagccgg agcccctgac ctggccaggg agcgtggaag ggggtggggg tgctccaggc
     6361 ctggaggccc tgactcgacc ccctgtcccc tgccctgcag aagcggaaca gggccatcac
     6421 ggcccgcagg cagcacctga aggtaggtgt gggctcccgg gggggtggcc caggtgggtc
     6481 tgcaggggag ctggctgcag cccctcaccg cctgccccac cgcagagtgt gatgctgcag
     6541 atagcggcca cggagctgga gaaggaggag agccgccgtg aggcagagaa gcagaactac
     6601 ctggcggagc actgcccgcc gctgcatatc ccgggctcca tgtctgaagt gcaggtacca
     6661 gcccctcccc ggccaccccg cctccccagc agcaggcctg cctgctaact cagtttcccc
     6721 acttgtcaag agggccagtg gggtggtcag ggcaggggca ggtgaccgtg gctgccaagt
     6781 gtcaggacgg ccgcccgccc ccacacccac ccctaggagc tctgcaaaca gctgcacgcc
     6841 aagatcgatg cggctgaaga ggagaagtac gacatggagg tgagggtgca gaagaccagc
     6901 aaggaggtga gtggtggcgg cgggccggcg gcaggcgggt aggcggtggc ccagcgggca
     6961 ggcggggcgg gccggggagg ccgagaccac cgggacctcg ggctcccacc cggctcccct
     7021 gcccacagct ggaggacatg aaccagaagc tatttgatct gcggggcaag ttcaagcggc
     7081 ccccactgcg gagggtgcgc atgtcggccg atgccatgct caaggccctg ctgggctcga
     7141 agcacaaggt gtgcatggac ctgagggcca acctgaagca ggtcaagaag gaggacacag
     7201 agaaggtgcg tgccacgggg ggagcaccac cacacctacc ctgccgggga agcacctccc
     7261 acacctgccc cgcctgggga ccacctccca cacctgccct gccgggggcc ctgtaccact
     7321 gcccctccag ggtgccatgc aggggacact ccactgccca atgcagaggg taaactgagg
     7381 ctgaaggtgg tgtggaccag ggtgcgtgca taagtgggtg agcctgagct ctctcctgcc
     7441 ctctcctcca caggagcggg acctgcgaga cgtgggtgac tggaggaaga acatcgagga
     7501 gaagtctggc atggagggcc ggaagaagat gtttgagtcc gagtcctagg ccactcgctg
     7561 cccctacgcc tgccccggtg cccggctccc agcagaacat actagggaga tgcacccaga
     7621 gcctgccagg gagggctggc ctcaccacca ccgtcaataa aggatttgaa tccccatggc
     7681 tggtctggtc tggctctccc cagcctcttg ggccatgctc tgggcccccg catcggtggc
     7741 ctgcagtgtg gtcagtggcc agcggggaaa gcctgggagg aggccacacg gggcctggga
     7801 tttcaggttg ggagggaagc tgcttccagc aaggaggtga gcctgggaag gcccctacag
     7861 gggaatccac cccaggctgc acggggctgt ttggtgaggg ccctgatagt gccccaggcg
     7921 ttcctggggc tcggcctggg cacatccaac atgcagggct ggggatggag gctgtgggac
     7981 cgagccaggt ctgggtggga gttcctgaga taagtgggtc tcacatttgc acagccacgc
     8041 aaaggccctc ccggggctcc agagagatcc acacatgtga cacacgtgtg gcccccgcag
     8101 tgctgggggc agccccctat gcctcccaag ctgcccctcc tcagggagct catctgaggc
     8161 aggaagccaa gggccacatt agaccccagg ctgctgtcca cgcgtgccca cccccagatc
     8221 ctcctgctca tccccctccc acatcacttt gggacagacc cccagccccg gggcctccct
     8281 gcttttccta tctgccccct gccctgagca ctgaggctgg gcacggggag cgtggagggg
     8341 cgagcctgca cggtgggcca tgaccaggcc aaattggcag tctccgggct ggggaccagc
     8401 atggtgctgg gggttggcca gcctggtctc tggtccttac tgccaccctg aaaggcaggc
     8461 tgtgtcactc ctcaccatgc caggggacca agagacctgt gcccatcagg caggggctag
     8521 gcctggccct gacctggctc cagtgtggct cccaagtctc gtttccactc agccccaaga
     8581 cccagcccca tctggccacc aaggacaagg cagctgacag gttctgacaa ggccggtgac
     8641 agcaaggcca cgttatcagc cctgctcttt gaaggctgac agagcaggca cgccaaggtc
     8701 cctgtgctca gatctgcgct ggggaggctg ccagcctgcg ctgtgccctt gcccccggga
     8761 ggtcccatcg attgatctgc cggaggtgga cgtgcagcgg cagttccgcc tcgggctgcc
     8821 ttgagggact gacgtcagtg ggctcccggg acggccttgg ctgtgtgcag tcccctgctt
     8881 cccgggtacc ctacagccct ggcactcagc tctgaccttt tctgtagctg gagccccacg
     8941 ccagtccgaa ccccccaccc gggccttctc ctttagcctt ctgtagggga aggcaccgag
     9001 cagggcagct tggggccaag ggggcactgc ctggtgggtg cagctgtggc agaggtgcat
     9061 ggcaccccat gccagaatga tgggaccagg caaggcccag ggtgtaggag gccatgaggc
     9121 acagaagtga ggcccgagac ctggcctgtc ggggggaagc tgcccaagcc caagcctcag
     9181 ctgagacctg agggaggaca agtgtggagg cagagggtgc tgcaggctgg agcacgtccc
     9241 atgcagagcc aggcaggcaa caggcagagc gagggacagg cggcggtggg gcctggccat
     9301 ggaccccttg caggggacat ggcacctttc cagagcctgt gcctactggg aaagggggcg
     9361 ggacccaatc ccacagggcg tcaggggggt gtggcagagg agttggggca ggcgcatcac
     9421 acctggctgc caaccacaag attcaacttg gccggggcag acacgctgtg tgggaaaatt
     9481 atctttttta tttcaaagca aggaaatgtt gaacacaaac acgaaattcc aaagagtgac
     9541 cctctggggt gagtggggtg ggggcagagc aggggcagaa tggagacagg acccctacgc
     9601 tgatgcaggt ttgggggatg ttttaattct tgggctggat agtagatgca cgggtgtttg
     9661 ttaaatttcc aatagatg
//

