LOCUS       NG_008691              35072 bp    DNA     linear   PRI 16-AUG-2009
DEFINITION  Homo sapiens survival of motor neuron 1, telomeric (SMN1) on
            chromosome 5.
ACCESSION   NG_008691
VERSION     NG_008691.1  GI:209413713
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Johan den Dunnen. The reference sequence was
            derived from AC139834.2 and AC044797.5.
            
            Summary: This gene is part of a 500 kb inverted duplication on
            chromosome 5q13. This duplicated region contains at least four
            genes and repetitive elements which make it prone to rearrangements
            and deletions. The repetitiveness and complexity of the sequence
            have also caused difficulty in determining the organization of this
            genomic region. The telomeric and centromeric copies of this gene
            are nearly identical and encode the same protein. However,
            mutations in this gene, the telomeric copy, are associated with
            spinal muscular atrophy; mutations in the centromeric copy do not
            lead to disease. The centromeric copy may be a modifier of disease
            caused by mutation in the telomeric copy. The critical sequence
            difference between the two genes is a single nucleotide in exon 7,
            which is thought to be an exon splice enhancer. Note that the nine
            exons of both the telomeric and centromeric copies are designated
            historically as exon 1, 2a, 2b, and 3-8. It is thought that gene
            conversion events may involve the two genes, leading to varying
            copy numbers of each gene. The protein encoded by this gene
            localizes to both the cytoplasm and the nucleus. Within the
            nucleus, the protein localizes to subnuclear bodies called gems
            which are found near coiled bodies containing high concentrations
            of small ribonucleoproteins (snRNPs). This protein forms
            heteromeric complexes with proteins such as SIP1 and GEMIN4, and
            also interacts with several proteins known to be involved in the
            biogenesis of snRNPs, such as hnRNP U protein and the small
            nucleolar RNA binding protein. Two transcript variants encoding
            distinct isoforms have been described. [provided by RefSeq].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15907             AC139834.2         169551-185457
            15908-35072         AC044797.5         32834-51998
FEATURES             Location/Qualifiers
     source          1..35072
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13"
     STS             4635..4740
                     /standard_name="D5S1556"
                     /db_xref="UniSTS:150384"
     gene            5001..33072
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /note="survival of motor neuron 1, telomeric"
                     /db_xref="GeneID:6606"
                     /db_xref="HGNC:11117"
                     /db_xref="MIM:600354"
     mRNA            join(5001..5244,18899..18970,21449..21568,22418..22618,
                     22778..22930,24718..24813,26126..26236,32001..32054,
                     32499..33072)
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /product="survival of motor neuron 1, telomeric"
                     /transcript_id="NM_000344.3"
                     /db_xref="GI:196115055"
                     /db_xref="GeneID:6606"
                     /db_xref="HGNC:11117"
                     /db_xref="MIM:600354"
     exon            5001..5244
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /inference="alignment:Splign"
                     /number=1
     CDS             join(5164..5244,18899..18970,21449..21568,22418..22618,
                     22778..22930,24718..24813,26126..26236,32001..32051)
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /note="isoform d is encoded by transcript variant d"
                     /codon_start=1
                     /protein_id="NP_000335.1"
                     /db_xref="GI:4507091"
                     /db_xref="CCDS:CCDS34181.1"
                     /db_xref="GeneID:6606"
                     /db_xref="HGNC:11117"
                     /db_xref="MIM:600354"
     exon            18899..18970
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /inference="alignment:Splign"
                     /number=2
     exon            21449..21568
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /inference="alignment:Splign"
                     /number=3
     exon            22418..22618
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /inference="alignment:Splign"
                     /number=4
     STS             22452..22584
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /standard_name="SMN1"
                     /db_xref="UniSTS:253711"
     exon            22778..22930
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /inference="alignment:Splign"
                     /number=5
     exon            24718..24813
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /inference="alignment:Splign"
                     /number=6
     STS             25607..25729
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /standard_name="D5F151S1"
                     /db_xref="UniSTS:156650"
     exon            26126..26236
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /inference="alignment:Splign"
                     /number=7
     STS             31844..32045
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /standard_name="D5S2797"
                     /db_xref="UniSTS:474072"
     exon            32001..32054
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /inference="alignment:Splign"
                     /number=8
     exon            32499..33072
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /inference="alignment:Splign"
                     /number=9
     STS             32666..32854
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /standard_name="D5S2798"
                     /db_xref="UniSTS:474073"
     STS             32712..32974
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /standard_name="STS-U18423"
                     /db_xref="UniSTS:106"
     STS             32827..33008
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /standard_name="D5S2463"
                     /db_xref="UniSTS:61210"
     STS             32866..32988
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /standard_name="A006I11"
                     /db_xref="UniSTS:8893"
     STS             32866..32988
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /standard_name="G20836"
                     /db_xref="UniSTS:8892"
     STS             32895..33008
                     /gene="SMN1"
                     /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@;
                     SMN; SMNT; T-BCD541"
                     /standard_name="D5S1946"
                     /db_xref="UniSTS:61211"
ORIGIN      
        1 tctgattggt gagcgatggt ggtaggtaaa accagtctta gagtcatggc agttcatttt
       61 agcagctatt aggtaaaact ggtcttaggg atacagaagg ctggttcagc agttggactt
      121 gtggaaaatt taattcttga agcagatgct gtgtgccccg aatgcttctt ccccctggcc
      181 cttcaactct gatttagttg agtatttcaa gaatgaccca atttatgtaa tcaactttca
      241 caggtataca tgtcttaaac tttaaacaga tgttttgggt tttgttgttg ttgtttttga
      301 gacggagtct cactctgttg tccaagctgg agtgtagtgg tgtgatctcg gctcactgca
      361 acctccgcct ccagggtcaa gtgattctcc agcctcagcc tcctgaatag ctgggattac
      421 aggcgcccgc caccacgccc agctaatttt tgtattttta gtagagatgg ggtggggttt
      481 caccatgttg gccaggctgg tcttgaactc ctgacatcaa gtgttctgct cacctcagcc
      541 tctgaaagtg ctgggattac aggcgtgagc cactgcgccc ggcagtcttt ccttcttttt
      601 tttttttttt tttttttttt taatgacatg gggtcttact ttattactca ggctggtctc
      661 aaacttctgg cctcaaggga tcttcccacc ttggcctccc aaattgctgg gattacaggc
      721 ataagtcatc atgcctggct acaaacagat attttcaata agaggataaa agttcatttc
      781 cccatacttt gctaacatca aatgttatta attcctaata gttttgccaa actgagagga
      841 aaatggtatg ttagtttttc tgggttttct ttctttttaa ttttttttct tttttattca
      901 tcgcaacact attcacgatt tttttatttt ttattttatt tatttatttt tttttttttg
      961 agacaaggtc tccctatgtt gcccaggctg gtcttgtacc cctgggctca aaggatcctc
     1021 ctgcctcagc ctcccaaagt gctaggatta caggcatgag tcaccacgcc tggttcacaa
     1081 tttctttttg tttttaccaa aggcaggtat attcctgaaa ttttttgttt ttttgttttt
     1141 tttttgagat gaagtctcac cctgtcactc agactggagt gcactggcac gatctcagct
     1201 cactgcaacc tccgcttcct aggttcaagc gattctcctg cctcagtctt caaagtagct
     1261 aggattatag gcgccgcaac catgctcagc taatttttgt atttttagta gagacaggat
     1321 ttcaccatgt tggccagggt gatctcaaat cctgacctca agtgatccgc ctgcctcagc
     1381 ctcccaaagt gctgggatta ctggcatgag ccaccgtgcc aggccctgaa atgttatctt
     1441 agttattaat ttgcaattcc ttggctctag aggttgggca tcttctcaga tctctagtgg
     1501 acatttggat tttctttttg gtgaactgtc cagtttttct ctctgcttta caatctttat
     1561 tatatgcaat cttcacatgt aggtactacc atttttttag tttgtttttg aaacagcata
     1621 ttgctctgtt gcccaggctg gagcacggtg gcaaaaacat ggcttactgc agcctttgac
     1681 ctccttggct caagtactcc tcctgtctca gcctcctgag tagctggtac cacaagccca
     1741 taccaccatg cccagctaat ttatttttgt agagatgggg cctgaccatg ttacttgggc
     1801 tcaaatgatc ctctcccact cagcctccca aagtgctagg attacaggca tgagccacca
     1861 tacttggccc tttttttttt tttttttttt ttttttttga gacagagtct tgctctgtct
     1921 cacaggctgg tgtgcagtgg cacgatctca gctcattgca acctccacct cccagtttca
     1981 agtgattttt gtgcctcagc ctccctagta gctgagatta caggcatgca ccaccatgcc
     2041 tggctgactt tcatatcttt agtgttgcca tgttggctag gctggtctca aactcctgac
     2101 ctcatgtgat ccacctgcct cggactccca cagtgctggg attacaggtg ttagccacca
     2161 ccccgacatt atttgaaact tttattttat catgagagag ttccaggagt caactgaaga
     2221 cagatttttg gtatgaaaat tacatatgca aaaagactga ttccagtaca tgaaattaaa
     2281 ttcaacattt acattaaatg ccttcaaata tggtaaaatg gtttcttttg gcagtttacc
     2341 tcattatgtt ttgaatgatt tgtctatcat atgaaataac ttttataaat atagtaactc
     2401 aggcctgggc acagcggctc aagtgggagg actgcttaag caaccgagtt tgagaccagc
     2461 gtggacaaca tggggagacc ccttctctcc caaaaaatag ctgagcatgg cagcgcactg
     2521 ttaaaggaaa cagagtttct ttggtgggtg attaaaatgt tctggagtta gatagtggtg
     2581 atggttgcac aaccttgtga atatattaag gtttccgctc aatctaccat tcaattgtac
     2641 tctctaaaat gattaattct atagtatatc aattatatct ctaaataata aaaacaaaaa
     2701 gaaatggctg ggtgcggtgg ctcatgcctg taatcgcagc actttgggag gctgaggcgg
     2761 gcggatcaca aggtcaggag tttgagacca acctgaccaa catggcaaaa ccccgtctct
     2821 actaaaaata caaaaattag ctgggcgtgg tggcacacgc ctgtaatccc aggtactcgg
     2881 gaagctgaga caggagaatc acttgaaccc gggaggcaga ggttgcagtg agccactgca
     2941 ctccagtctg ggtggcagag cgagactccg tctcaaaaag aaaaaaatta aaaaacaaaa
     3001 agaaacctgg ttctatattt tgtttaaatt tattttttta accatcatgt aatatgtcca
     3061 cgtaatttgt ttaaattttg acatcaaatg caattgtgag aatttttatg attcagaaaa
     3121 atctaagcaa gctttataaa aacatacttt tttttttact tttttttttt tttctgagac
     3181 acagcctcac tctgtcgccc aggctggagt gcaggttttc atgtttatct gtgagatgta
     3241 cctttggcac attactttcc tgacatgaga tttaaaattt ttttttttat cttgtgacaa
     3301 tttaactttt ttgacacata aaaattgtac atatttattt gtttgagatg gagtcgcact
     3361 ctgtcactca ggctggagtg cagtggcgtg atcttggctc actgcaacct ccgcctcccg
     3421 agttcaagag attctcctgc ctcagcctcc caagcagctg tcattacagg cctgcaccac
     3481 cacacccggc tgatttttgt atttttagga gaaacagggt ttcaccatgt tggccaggct
     3541 ggtcttgaac tcctgacctc aagtgatcca cccaccttgg cctcccaaag tgctgggatt
     3601 ataggcatga gccaccgtac cagaccccta aaaattgtat atatttaagg tgtaccattt
     3661 gatgtttaga tatacattgt gaaatgatta cattccacat attacctcta cggagttacc
     3721 atttttgtac acttggtcaa catcatccca ttctcccctt cctccacaga tatttcttgt
     3781 atactatata gaagccaagg gtattttggg ggaagagctc aaagttcctt tcgtggagtt
     3841 aaaaatatat atatactatg tacatataag ccatttagca accctagatg cttaataaag
     3901 aatactggag gcccggtgtg gtggctcaca cctgtaatcc cagcactttg ggaggccgag
     3961 gcggtcggat tacgaggtca ggagttcaag accagcctgg ccaacatggt gaaaccccat
     4021 ctttactaaa aatacaaaaa ttagccgggt gtggtggtgg gcgcctgtaa tcccagctac
     4081 tcggggggct gaggcaggag aattgcttga acctgggagg cagaggttgc agtgagctga
     4141 gatcacgcca ctgcattcca gcctgggtga cagagcaata ctctgtcgca aaaaaaaaaa
     4201 agaatactgg aggctgggcg aggtggctca cacctgtaat cccagcattt tgggatgcca
     4261 gaggcgggcg gaatatcttg agctcaggag ttcgagacca gcctacacaa tatgctccaa
     4321 acgccgcctc tacaaaacat acagaaacta gccgggtgtg gtggcgtgcc cctgtggtcc
     4381 tagctacttg ggaggttgag gcgggaggat cgcttgagct cgggaggtcg aggctgcaat
     4441 gagccgagat ggtgccactg cactctgacg acagagcgag actccgtctc aaaacaaaca
     4501 acaaataagg ttgggggatc aaatatcttc tagtgtttaa ggatctgccg ccttccttcc
     4561 tgcccccatg tttgtctttc cttgtttgtc tttatataga tcaagcaggt tttaaattcc
     4621 tagtaggagc ttacatttac ttttccaagg gggaggggga ataaatatct acacacacac
     4681 acacacacac acacacacac acacacacac tggagttcga gacgaggcct aagcaacatg
     4741 ccgaaacccc gtctctacta aatacaaaaa atagctgagc gtggtggcgc acgcctatag
     4801 tcctagctac tggggaggct gaggtgggag gatcgcttga gcccaagaag tcgaggctgc
     4861 agtgagccga gatcgcgccg ctgcactcca gcctgagcga cagggcgagg ctctgtctca
     4921 aaacaaacaa acaaaaaaaa aaggaaagga aatataacac agtgaaatga aaggattgag
     4981 agaaatgaaa aatatacacg ccacaaatgt gggagggcga taaccactcg tagaaagcgt
     5041 gagaagttac tacaagcggt cctcccggcc accgtactgt tccgctccca gaagccccgg
     5101 gcggcggaag tcgtcactct taagaaggga cggggcccca cgctgcgcac ccgcgggttt
     5161 gctatggcga tgagcagcgg cggcagtggt ggcggcgtcc cggagcagga ggattccgtg
     5221 ctgttccggc gcggcacagg ccaggtgagg tcgcagccag tgcagtctcc ctattagcgc
     5281 tctcagcacc cttcttccgg cccaactctc cttccgcagc ctcgggacag catcaagtcg
     5341 atccgctcac tggagttgtg gtccgcgttt ttctacgtct tttcccactc cgttccctgc
     5401 gaaccacatc cgcaagctcc ttcctcgagc agtttgggct ccttgatagc gttgagtgga
     5461 ggccctgccg cgacttggca gtagcttatt ttgttcactc ctctctggct ggtgtggggg
     5521 aggtgggggc attaggccag ggtgaagcag gggaaccact taggagtctg ttaagatgat
     5581 ctgaacttca gaacaagatg ttattaacag agtgaaagta tttggattct gggtatattt
     5641 tgaaatcgga ggcaacaggt ttttcagata gattcgataa cggaggttat cctgaatagt
     5701 tgaaaagata aagttgcctt ttgctgaggt gggaaagaga agattgccag tagagcaggt
     5761 ttctcaggag ttcagtcttg ggcatagcat ggtaggggtg aatttggctg gagtgagttg
     5821 gagagtagga gaagagaaat ccaaggcaac atttgaccag cctgggcaac atagtgtgac
     5881 tccgagtctg caaaaattag acgggtgttg tggtgcgcgt ctgtggtctc agctacctgg
     5941 aaggttcagg ccttggaagg ctcagggagg tggaggctgc agtgatctgt gattgcgcct
     6001 ctgcactcca gcctgggcga cagagccaga ccctgtctta aaacaaaata aacggccggg
     6061 cgcggtggct caagcctgta atcccagcac tttgggaggc cgaggcggcc ggatcacaag
     6121 gtcaggagat cgagaccatc ctggctaaca cggtgaaacc ccgtctctac tacaaataca
     6181 aaaaattagc cgggcgtggt gacgggcgcc tgtagtccca gctactcggg aggctgaggc
     6241 aggagaatgt catgaagccg ggaggcggag cttgcagtga gccgagatcg cgccactgca
     6301 ctccagcctg ggcgatagag caagactccg tctcaaataa ataaataaat aaataaataa
     6361 ataataaaaa catcggtagg catatttcaa ggaattctat ttaaaaaaaa tttttttaga
     6421 gacaagttcg ctctctgtgg cccaggctgg agtacagtgg catgatccta gcccatggca
     6481 gcgttgatct cttggcctca agcgaccctc ctttggagtc gctgggccta aaggagtgag
     6541 ccaccacgaa attttattat aaatggaggg tagagaaatt gggcaataaa tggaggggga
     6601 agtgagttaa gaggaatttt aattatgtgt gtgtggtttt aaaagagggg ggtcttgctc
     6661 tgttgcccag gctgctgggg tgccagtggc gcaatcatga atcactacag ccttggactc
     6721 ctggcctcaa gctatcctcc cacctctgcc tcccaaagta ctgggattac tagtgtgagc
     6781 cactgcacta agataggagc aacatgtttc agcatgtttg tgggttgata ggaaagatga
     6841 gaatgggaaa gttgatgtcg gaaagaagac aatggctaga gcaatgtcct agagtaggta
     6901 agaagggatg gatttggcct ttgttggaaa cattagcggt tcttttggtg acagctatat
     6961 agttaacaca tctatgatac gtgaatgggc agataggatg gcaggagatt ttgaaagttc
     7021 tcttgattct tactgttctc ttagtgaaag aagcaaggtt atcagctaga agctgggatg
     7081 ggagaggaaa gagaagatgg gaagtagata gttctttaga agagtgggca agggttggac
     7141 tagggaagtt tagtggaaat attgctaggc aacataaaga gcctacttga gattcgtggt
     7201 catgagttga aggagaccag acagcaagat tgtgtatgag ggcacccaca gagtaaatgg
     7261 agagttgaaa ttaatgcagt tgtgatttta ccacgtggat atgaagaagt gagggggaga
     7321 agtacaaagg agttctctta atgattgacc atggaattta agctggctaa gaaaggaagt
     7381 gagaggccgg gcgcggtggc tcacgcctgt aatcccagca ctttgggaga ctgaggtggg
     7441 tggattacct gaggtcagga gtttgagacc aacctggccg atatggcgaa accccatctc
     7501 taataaaaat acagaaaaat tagccgggaa tggtggcagg tgcctgtaat cccagctact
     7561 caagaggctg tggcaggagt atcccttgga cccaggaggt ggaggttgca gtgagccgag
     7621 atcacgccac tgtactccag cctggacgat atagtgagac ttcacctcaa aaaaaaaaaa
     7681 aaaagaaagg aagtgaggat tttaagaccc tgagagacag tttaaaaagt gggaggatcg
     7741 gccgggcgct gtggctgaca cctgtaatcc cagcactttg ggaggccgag ttgggcagat
     7801 cacaaggtca ggagttcgag accagcctgg ccaatatggt gaaaccttgt ctctactaaa
     7861 aatacaaaaa ttagccgggc atggtgtcac gtgtctataa tcccagctac tcgggaggct
     7921 gaggcagaaa aattgcttga acctgggagg cagaggttgc agacagctga gatcactcca
     7981 ttgcactcca gcctgggcaa caagagcaaa actttgtctt taaaaaaaaa aaaaaaaaaa
     8041 gaatacaaaa attagccggg cgtggtggcg cgtgcctata atcccagcta cttgggaggc
     8101 tgaggcagga gaatcagttg aacacgggag gcgaggtttg cagtgagccg agattgcgcc
     8161 actgcactcc agcctgggcg acagagcagg actcctcttg gaaaaaaaaa attagctggg
     8221 catggtggca ggtgcctgta gtctcagcta ctagggaggc tgaggcagga aaatcacttg
     8281 aacccgggat gtggagtttg cagtgacccg agatcgtgcc actgtactcc atcctgggcg
     8341 acaaaatgag actctgcctc aaaaaaaaaa aaaaaaaaaa aaaaagtggg aggatcaatg
     8401 tactgccagt cctaatgaag tggaatgatt gtccccatca aatcactagt aggagtaagt
     8461 tgcagagcct agaaggtgat ggttaagaga gtgggattct tgaaactgca tttatggaga
     8521 ggttgtggtt attggttata ataaataaat acagttgaag tgagtgagta gctgagattt
     8581 ggggatgtat cagttcattc ttacactgct acaaagacat acctgagacc aggtatttat
     8641 aaagataaga ggtttaatca gctcacagtt ctgctgcctg tacaggcttc tcttgtggag
     8701 gcctaaggaa acttacagtc atggtggaag gtgaagggga aacaagcaca gtcttcacat
     8761 ggccagcagg agagagagag aagggggaag tgctacatac tttaaaacaa ccagatcttg
     8821 tgagaacgct tatcaggaaa cagcacttgg ggatggtgct aaatcattag aaatcacccc
     8881 catgatccag tcgcctccta ccatgcccac ctccaacact ggggatcaca attcagcatg
     8941 agatttgggt aggaacacag agctgcacca catcagagga tgtacaagat tgtggtggag
     9001 aggagtttag agacctgcaa atatagggta attgaaggga tcatctacat ggatatttaa
     9061 atcaccaaaa attatgacag gagtagtgtt ggagagagaa ctgcgatgta aacattaagg
     9121 aatgaggaag agtgactcgg taggctgtag gtgactgcaa taggaaacga taatagactg
     9181 tgagtctggt gacaagattt tccttctttc tttttttccc cccccccgag acagggcctc
     9241 tttttgttgc ccaggtggga gtgcagtggc gcgatcacgg ctcactacaa cctcctccca
     9301 agctcaaggg attctcccac ttcagcctct caagtagctg gaactacagg tgctgaccac
     9361 catgcctggc tactttttgt caggattttc aaggctggga attttgagag gggaatggag
     9421 gagaataatc tgaaagtgca agtaaggagc agggaagatt tcttttttct tttttttttt
     9481 tttttttgag tcggagtctg gctcagtcgc ccaggctgga gtgcagtggc gagatctccg
     9541 ctcactgcaa gctccgcctc ccgtgttcac gccattctcc tccttcagcc tcccgagtag
     9601 ctgggactac aggcgcccgc caccacgccc agctaattgt ttttttgtat ttttagtaga
     9661 gacggggttt caccgtgtta gccaggatgg tctcaatctc ctgactttgt gatccgccca
     9721 ccccggcctc ccaaagcgct tgggattaca ggcgtgagcc accgcgccag ccagagcagg
     9781 gaagatttct tccccacatc tccagtaggt acagtgatat gaagtgtgtg gaggagaaaa
     9841 gaggaaacat ctatcatttg agatggctgc gaaaggaaaa ggcatcctca gggagctaga
     9901 ttttacttag agcaagaaat gaagggatga ttcagaggtt aaaagagtgg attttatgaa
     9961 ttactcaagg gagcacagtg gaagtttcag gaagtggtag gagaaggtag aagatggcag
    10021 ggtgttggga ataatttgag aaatctgagc tactggaaat gactgagaat cagatataaa
    10081 ggcagtcctg gtggtccgtt ctggctgccg ttgctgtgta acgaatctgc caaaacttag
    10141 tggcttgaaa caacaaagaa cattttatta tctctcattg tttctgtggg ttaggaattt
    10201 gtgagagccg tgctgggcag ttttcgtgcg gctgtctcgt ggttgcacct acatagttgc
    10261 tagagctaca gtagctgggg actgagcagc tagggattgg caggctatct ctttttttca
    10321 tgtagtctca tgaagatttc tttatgtggt ttcaatgtgt gggctggttt ggatttcctt
    10381 atagcatggt ggcctcagtt ggattgctgt tttgtgatcc ttttcatccc tccttgtcct
    10441 gtccccagac aaccactgat ctactttctg tcaccataga ttagcctgca tttttaagaa
    10501 tttttataaa cgtggaatga tagagtacct tttttgtcac gtttctttta tttatcatag
    10561 ctattttgat tttcatccat tttattgctg agtagtatcc cattgcatgt atatactata
    10621 ctgtattcat tcgcttgctt gtgaacattt gggctttttc cagtttggga ctgttaacaa
    10681 gtagagccac tatgaatatt agtgtataag acttcatata gccaaggctg gcagatcgct
    10741 tgagcccagg agtttgagac cagcctggga aacatggtga aacctctatt tttattttaa
    10801 aatcaaaaat taaaaatttt ctataaaaaa ttttaaagaa gactttgtat agacatacgc
    10861 tttcattttt cttgagtgaa tacttaggtc tcagggtaga tgtattttaa gtctttaagg
    10921 agctgtcaaa ctcttcctca aagtggtggt tgtaccatgt tactttttaa tataacagag
    10981 attaattgag caaagaaaaa ttcaaaagtt ggacagcccc cacaactaaa taggttcaga
    11041 acagctcccc cattttgcat tttgaccagc aatgtatgaa agttccattt gctcagtgtc
    11101 cctgcaaaca cctggtatgg tcagtctttt taattttagg cattataata gatatagtgg
    11161 cttcttgtga ttttaattag catttcctaa tgaccagtgc tgctgttgat catttcatga
    11221 gtgtatttgc catccgtata tcttttttgg tgaagtgtct attcaaatca tttgggtttt
    11281 tttttttttt gttttttttt tttggagaca gtgtctcact ctgtcaccca ggctgttgtg
    11341 cagtggtgca atcacacagc ctactgcagc ctccacctcc tgcgctcagt cttcttgtct
    11401 cagccttctg agtagctgaa attacgagca cacgccacaa tgcctggcta attttttaaa
    11461 attttgtaga aacaaggtct cattatgttg cctgggcttg tcgtgaactc ctgggctcaa
    11521 gcaatcttcc tgcctcagcc tcccaaagat tgggattgca agtatgagcc actgcacccg
    11581 gccaacttac ccatctttta attgaatttt tttgttgttg aggtttgaga gttcttcatg
    11641 tttgctgggt acaatatctt tatcagatag gtaacttgca tgtattttct cccggtttac
    11701 actttggttt ttcattttgt taacaacgtc tttttaagaa cagaaaatct taattttgct
    11761 gaaatctaat ttttcagttt tttctttgat ggttttgaga gaggaggtaa aaaaagacta
    11821 ggtaagccga tagttagaca gagtcctcgg tagaacttcc cttctaacaa aaagcagccc
    11881 aagaaatcac ttctcttcta acaaggagca gcctggaaga tcgggctgta aacatgtata
    11941 aggaagcagc tctggcacag agggggagct tcctgggtaa tcagcaagct tcacatacgt
    12001 aaggtgggta tgtgaagtaa acacagtatg tgaagtaaac acagtggacc ttagtacata
    12061 ctcagataag gaagctggaa gcttgcatgt tgtgagttgt tggggttgcc tgcagctgca
    12121 cggagagaaa ggggtacctg gggccaggca tgtccaccat ggtggctcca cctcccctta
    12181 tttagcacat gcacaatagg aaagagataa gcaatgtgga gtagctcagg ccaaggacct
    12241 gcctgcataa taaaaggttg gggtggggga tgccagagat tcacgctctg tgcagatggc
    12301 aacacctggt cctaactggt tttttgctcc ctatgtgtag ataagctacc cccttcccat
    12361 tagctcattt ataaaaatgc ttgcatttca ctgtggaatg ggaactcttt tcaggacctc
    12421 tctctgcagg agagagctag tctctttctt ttgcctatta aacttctgct ctagcctcac
    12481 acccttggtg tgtcagcgtc cttgatttcc tcagcgtgag accaagaacc tcgggtgcca
    12541 ccccaggcaa caaggccatt tcagtttgtt cttttgttat aggcaatcca tgatcacaga
    12601 tttttctctc tttttttttt ttacacagtt tagagtttta gttttacact taggtctgta
    12661 atccattttg tattaattct tatatgtggc tcagtgtagg tggaaatttg gtttgttttt
    12721 gcataaggat ttccaatagt tttaccacca tttcttgaaa ctactatgct ttctctatta
    12781 aaccacattt gtaactttag ttaaaatcag tcacatatat cacagggcta tttctgactc
    12841 tcaattctgt tacattgtct attagtgtat attgatgtca gtactacact tttaattact
    12901 attgcttcag ggtatgtctt gtaaaccaaa aataaaatta taggcccccc ccgcccctgc
    12961 acaaccaact gaatggaccc atcctctcag ccaagggcat tccaaaatta acctgaaaaa
    13021 ctagttcaag ccatgatggg aagggggagt tggacatgtc tcatcacacc ctactacctt
    13081 ttggaattac tgatagaaca gactcttaaa gtctgaaaag aaacatttac aacctaccct
    13141 ctctgaagcc tgctacctgg gagcttcatc tgcatgataa aaccttggtc tccacaaccc
    13201 cttatggtaa cccaaacatt cctttctgtt gataataact ctttcaacta gttgccaatt
    13261 agaaaatctt taaatcttcc tatgacctag aaacctccct acccccactt tgagttgtcc
    13321 tgcctttcct gacagaactc atgtacatct tacatatatt gattgatgcc tcatgtctcc
    13381 ctaaaatgta taaaacaaag ctgtacccca ccaccttggg gacatgtcat caggacctcc
    13441 tgtggctgtg tcataggagc gtctttaact ttggcaaaat aaactttcta aattgattga
    13501 aacctgtctt agctacttct ggtttacagt cttaaagtta gataatgtaa attgtccagc
    13561 tttggtttat ttttgtcctt agtagttcca tataaatttt agaatcagct tttcaattta
    13621 atacactact ttcctcttag atccacaatt aaatatattt gatgctaaca attctgtttt
    13681 atgtttttcg tttttttttt ttgagacaag agtttcgctc ttgttgccca ggctggagtg
    13741 cagtggcgcg atcttggctc accacaacct ccacctccca ggttcaagca attcttctgc
    13801 ctcagcctcc cgagtagctg ggattacagg catgcgccac cacgcccggc taattttgta
    13861 tttttagtag agacggggtt tcaccatgtt gatcaggctg gtcttgaact cctgacctca
    13921 ggtgatccac ccacctcggc ctcccaaagt gttgggatta caggcgtgaa ccaccatgcc
    13981 tggccagttc tgttattttt aaaacccaag tttccctggt catatcttgg ttggatgaag
    14041 cgtattttca atagattacc ctggaaaggc tagtgagtac ggtattcttc tacattttag
    14101 acttttctta gtcttgctac ttcaaggaca gctaggctgc atataaaatt cttggctcat
    14161 actttttccc cataaatttc tatgagaaag tctaatgata actgattttc tttattttgt
    14221 aacttagtct ttttgcttag aggctctctg aggatgggag ggggttcttc ctcccatccc
    14281 taggaatttt tctttttttt aaattcctaa tcactagacc accaggaaga ttgtttgttt
    14341 tgttttgttt ttattcttca gggaccccat ttatacatac gttaaataaa tactgtttgc
    14401 caatgtatca accattttgc ttcttattta tttttgttcc tttggttctt tttcatggct
    14461 ttgctttggt gctccttaga ttttcagtca gatgtatttg tccttgggta ccttgtaatc
    14521 agtattacct tttcttctgt cgctttgttt tctgttcgtt ttgaaattac ttgtttcctg
    14581 gtctggcaat aacagttgag atatgaggag tttgagctgc catctgtcta tgtatcttgc
    14641 tttaagactg cactcttcta ttgatatcac tggccttgat tttgtgattt ctttatttct
    14701 tcaggaccac ccttcatttt ctactgtttg cttccttttt ttttgagatg gagtctcact
    14761 ctgtcactca ggctggagtg cagtgatctt ggctcattgc aacctctgcc tcccgggttc
    14821 cagcaattct cctgcctcag cctcccaagt atctgggact acaggtgtgc accaccatgc
    14881 ccggctaagt tttgtatttt taatagagac ggggttttgc cacattggca ggctggtctc
    14941 aaactcctga tgtcaagtga tccacccacc ccacccacct ctgcatccca aagtgctggg
    15001 attacaggaa tgagctgccg tgcccagcct cccccctacc cccctttttt tctttcgaga
    15061 cagagattat aggtgtgagc cactggaccc agcctgtttt tattcctttt accaaatctc
    15121 caaggaatat cttcccttcc aagtgcgaat gtaaccttaa gtcagttaac ctctttgtga
    15181 ttacttttct tatctgcaaa gtgacttaat gatcttaagt actttttttt tttgagacag
    15241 ggtctcactg tcaccctggc tggagtgcag tggcacgatc tctgatctcc actcactgca
    15301 atctcctctt ccctggttca agcggccctc ccaccttagc cttctgggta gctgggacta
    15361 cagatgtgaa ccaccacgcc cagctaattt ttgtactttt tgtagagatg gggttttgcc
    15421 atgttgccca ggctgggatt attaagtact ttttatcata cagcaagatt gacattttat
    15481 attggaatac atttgtctct atataacgga gattaacagg aaaatgacaa gcctgggtgc
    15541 ggtggctcat gcctgtaatc ccagcacttt gggaggctga ggtgggagga tcacttgagg
    15601 tcaggagttc gagaccagtt ttgccaagat gatgaaagcc catgtctact aaaaatacaa
    15661 aaattagccc agcttgatgg tgggcgccta taatcccagc tatttgagag actgaggcag
    15721 gagaatcact tgaacctggg cggcagaggt tgcagtgagc cgagatcatg ccactgcact
    15781 ccagcctggg tggcatagcg agactcttgt ctcaagagaa aacaaaacaa aacaaaaaaa
    15841 aaacaggaaa atgacaaaaa gtaatattac aactcagtga attttataac aaactttttt
    15901 ggaattcatt gactaatact ataccaaatc caaaatactc tctagtatac caaatccaac
    15961 tctaccctat agtataaatt ggattctatt tggacttgtc tcactaatcc ctcatacagt
    16021 gtgttttatt ttttattgaa gtaaaaaaat ttgtcatttt aaccattttt aagtatatag
    16081 ttcagtaata ttaagtatgt tcatgttgtt gcgcaataga tcttcggaag tttttcgtct
    16141 tgcaacctga aactctaccc attagcaaat tcccatttct ccttacactt agcccttggt
    16201 aatcatcatt cttttttttt tttttttgag atggagtttt actcttgttg cccaggctgg
    16261 agtgcaatgg tgcaatctcg actcaccaca acctccgcct cccaggttca agcaattcta
    16321 cctcagcctc ccgagtagct gggattacag tcatgcacca ccacgcccgg ctaattttgt
    16381 atttttagta gagaaggggt ttctccatgt tgaggctggt ctcgaactcc tgacctcagg
    16441 tgatctgccc acctcggcct cccaaagtgc tgggattaca ggcgtgagcc actgcgcctg
    16501 gcccattctt tctaattcta taaatttgac tacttagtta ccttacataa ataaattctt
    16561 atagttagtg ttatttttgc ttccatgcct tttttgttgt tgttcatgct cttacttgga
    16621 atgcgttcta ttttgtctac ctatgcacat cctgttgggt tttttttttt tttgggggtt
    16681 ttttttgttt ttttttgttt ttttttccca gacaaggtct caatttgtta cccaggctgg
    16741 agtgcagcgg cgccatctcc actcactgca tcctcaactt cctgggccca ggtgatcctc
    16801 tcgcctcagc ccctgcaggt agctgggact ataggcatgt gccaccatgc ccagctaaat
    16861 ttggtttttt tgtttgtttg tttttgagac agagtctcac tctgtcaccc aggctggagt
    16921 gcagtggcac aatctcagct cactgcaatc tctgccgccc gggttcaagt gattctcctg
    16981 cctcagcctc ccaagcagct gggattacag gtgactgcca ccacgccagc taagttttgt
    17041 agttttagta gagatggggt ttcaccttgt tggccatgct ggtctcgaac tcctgacctc
    17101 gtgatctgcc tgcttctgcc tcccaaagtg ctggaattac aggcatgagc caccacgccc
    17161 ggccagaatt tttgtatttt tagtagacac aaggttctta ccctgttgcc taggctggtc
    17221 tggaagtcct ggactcaagc aattcacctg ccttggcctc ccaaaatgct gggattacaa
    17281 gccaccatgc ccggcctaaa tcctgttgtt ttgttttgtt ttattttgtt ttgttttgtt
    17341 ttgtttgttt tttgagacag agtctcgcta tgtctctcag gctgtagtgc agtggcgcga
    17401 tcttggctca ctgccacctc tgcctcccag gttcaagtga ttctcctgcc tcagcctccc
    17461 aagtagctgg gattacaggc atgtgctact atgtccggct aatttttgta tttttagtag
    17521 agacagggtt tcaccatgtt ggccaggctg gtctcgaact cctgacctcg tgatccaccc
    17581 acctcggcca cccaaagtgc tgggattaca ggcgtgagtg gtttttattt cttaggccgg
    17641 tttcctccat atgatcttgc agtagacatt aatttctttc ctttttaatt aaaatactgt
    17701 ttgtatttca cattttgatg tttgttaaga tttgttttat attgtttttt gttttgtctt
    17761 gtgtgatagt cttaaatccc tagttagata ataactggag agtaccatgt ttctatatat
    17821 ctctcagtga cttgcacagt gctagcagat agtgctaaaa aattatttat tattattatt
    17881 attttgttat tgttgttgtt gttgttagac agggtcttcc tctgtcaccc aggctagagg
    17941 gcaatgggat gatcatagct tactgcagcc tccaacaact gggctcatgt aattctcctg
    18001 cctcagcttc ccaagtagct gggattacag gcatgagcca ccatgtctgg acaaaaatat
    18061 ttccaggtgc agtggctcat gcctgtaatt cccacacttg ggaggccgag cgaggctgga
    18121 ggatcacttg agcctaggag ttcaagacca gcttggctaa gatggcgaga ccccgtccct
    18181 acaaaaaatt ttaaaaacta gccaggcatg gtggcatgca cctatattcc caactactca
    18241 gtgggctgag gtgggagggt catttgaaca caggaatttg aggggagaaa aaaagaagag
    18301 agaaagagaa gtgaaggaag gaagaaagga aggagggagg gagagaagaa agaaacgaaa
    18361 gaaaggaaaa gaaaaggaag gaaagaaaat tggtaccagg aaagcaggaa agggaaatgg
    18421 aagtaaaaaa ataataataa taataaaatg aaaattggtt agtcactatt aacaatttgt
    18481 atccttataa tctggaaaca ttataatttc aaaagaaaaa atattctttg gatcataggt
    18541 tctgaggtca gaacagcatt cccgtagtct agatgaagtc aagttttatc tgatcttaat
    18601 tgaaataaat atagctggcc ttgaacaaat ctactcatgg tatgtggata ggaattaaat
    18661 tgtaggggca ttcacttgat ggcattcatt cttagaacat ttacctatgt ctagcttttg
    18721 gagtaaagtc acataacctc taaccaggta agtttcctgt ggctttattt aggattttaa
    18781 atactcattt tcagtgtaat tttgttatgt gtggattaag atgactcttg gtactaacat
    18841 acattttctg attaaaccta tctgaacatg agttgttttt atttcttacc ctttccagag
    18901 cgatgattct gacatttggg atgatacagc actgataaaa gcatatgata aagctgtggc
    18961 ttcatttaag gtatgaaatg cttgcttagt cgttttctta ttttctcgtt attcatttgg
    19021 aaaggaattg ataacatacg ataaagtgtt aaagtacatg ttattcagtt ttcattttga
    19081 agattagatg gtagtatgag ttagttaaat caggtgatat cctcctttag aagttgatag
    19141 cctatatatg tcatcctttg tggaggcaat ttaaataaaa tttaaaacat ttattcctgg
    19201 ctgggtatgg tggctcactc ctgtaatccc agcactttga gaggctgagg cgggtggatc
    19261 acctgaggtc aggagtttga gaccagcctg gccaacatgg tgaaaccccg tctttactaa
    19321 aaatacaaaa attagccaag catggtggca cgtgcctgta atcccagctg cttgggacac
    19381 tgaggcagga gaattgcttg aacctggggg gcagaggttg caatgattgc accactgcac
    19441 tccagcctgg gcgatagagt gagactccat ctcagaaaac gaacaaacaa tgtattcctt
    19501 ttagtatttt tacattgtat caaactatgg aagtcctcta attgagatta ataagaaaaa
    19561 gacaatctga attataattt taaacattta acaagcatgt agtaaaataa tgatgaagat
    19621 aaatagcatt agtacagcaa ttaatatttg tagcatgctg acagtgctct gtgtgcgttt
    19681 catatattaa attactctaa tcatcccaaa tcctgtaagt tgggtatcaa ttcaagtgtt
    19741 cctattgggt aggaatatac agttctttta ggaaatgtag tatggttctg tgtctcaaac
    19801 aggacactta cacagttggc caacatcatc accttctcca ttctctgaga tgtttagtct
    19861 tactgagcac taaatatggg tcatcaatag tccagactac cttgagcaaa caatagtcca
    19921 gactaccttg agcaaacaga gcatatactc atacagtgta taaagagcac caagcataca
    19981 gatttcatgt ctttctcata gttactcttg taacatgagc taaagatcag acctctatgt
    20041 cacctttgta actgatttct agattttttt ttttttttga gatggggtct tgccctgtca
    20101 cccaggctgg agtgtagtgg cgtgatcatg cctcattgga gccttcaact catgagctca
    20161 aacaatcctc ctacctcagc ttcctgagta gttgggacca caggtgtgtg ccaccacacc
    20221 cagctcattt ttgtattctt tgtagagatg cagtctcacc ctgttgccca cgctggcctg
    20281 gaactcctga gctcaaaaga tccctccgcc ttgaccttcc aaagtgctgg gattacaagc
    20341 atgaaccact gcacccggcc tagattttta aatgtgcttt ccagtataca ctgaaactag
    20401 aagtcgacta aagaattacc aagagaattc tataaaatag agattgaaat ggggctcgat
    20461 gtgggatggg ttggtgatat tgcagggaga agtaatctga gtaaaggagg aaaagaactg
    20521 atttgggaaa acgatagttt tagtagtgag tttgagtatg aattaagttg agattgaatt
    20581 tgaattaagt tgaggttgaa tatgaattaa gttgaggttg agtttgaggt atgaattaag
    20641 atgtgaaatt gatcattgga aatgttagat tgagaaaagt cacagctgga ttaatagctt
    20701 cagaagtgtg tttgcagaca gttgcaacta aagtaataag aatagatggc cttggccggg
    20761 cgcggtggct cacgcctgta atcccagtac tttgggaggc tgaggcgagc aaatcacgag
    20821 gtcaggagtt caagaccagc ctggcccaca tggtgaaacc ccgtctttat taaaaataca
    20881 aaaattagct gtgcacagtg gtgcacgcct gtaatcccag ctactcggga ggctgagaca
    20941 ggagaatcgc ttgaacctgg gaggtggagg ttgcagtgag ctgagatcag tgtgactgca
    21001 ctccagcccg gtgacagagt gagactctgt gtaaaaaaat aaaataaata aaataatggc
    21061 cgtaagcaag taaagaagga tggccagctc ttattgggaa tgcctaaatc taaggcttga
    21121 tcagaagtaa tgaaaccgtt ggggccctac attgctatga catccaaagg gccatgaata
    21181 tcaggaagaa agataattaa cagggtctaa tgttacagag aggttgagag caaggagatt
    21241 tgattaaaag ggtctttaga gctgatgtca ggtgtatgat gcctttaaga gcagttttta
    21301 tagtgcaggg ggtggtcaaa agagaaaata ggtgctttct gaggtgacgg agccttgaga
    21361 ctagcttata gtagtaactg ggttatgtcg tgacttttat tctgtgcacc accctgtaac
    21421 atgtacattt ttattcctat tttcgtagca tgctctaaag aatggtgaca tttgtgaaac
    21481 ttcgggtaaa ccaaaaacca cacctaaaag aaaacctgct aagaagaata aaagccaaaa
    21541 gaagaatact gcagcttcct tacaacaggt tattttaaaa tgttgagatt taacttcaaa
    21601 ggatgtctca ttagtcctta tttaatagtg taaaatgtct ttaacttaag tgattagtac
    21661 agtgtttcta ttgacatata cttatacaac ttcaaaaaca actattaaat tttctgttat
    21721 ttaggaacat gcatattagt catgaaagta taaagaatta gatgggaatg ataaatgcta
    21781 aaatcaggac atgtgttcca tttgtgaatg gaaggcaggg agaaggtgcc gtttggaagg
    21841 agtacccaag agccgtaagc tgaattggca gtgttttaca tcttaagctg agagatagat
    21901 ttttttttcc cctttttctt taaaaactct aaaactgtta attccaagga acccagaagt
    21961 ctaggtagat tatttctgct agttaaaagc agtagtcctg aaagctgaat attttggtgt
    22021 cttttgagcc aactttagtt tcatcattac caagggggaa gagagctaac agttgatgag
    22081 cacttgctct aggccagtcc agagtgctgg gcaccatacg cattttatct ccctcccgct
    22141 attcacaaca aatatgggag gtagtttata ttatagccat ctaataagat ggggaaacta
    22201 agactcaaag agattcagaa acttgtccat gattataaat gtaagagagt tggaattcag
    22261 atttatgtat ttagacccca agcctttctc attacatcat tttgccttcc aaatctctac
    22321 cctctatcct tcacctcccc actgatcaaa acgagatgat agtttgccct cttcaaaaga
    22381 aatgtgtgca tgtatatatc tttgatttct tttgtagtgg aaagttgggg acaaatgttc
    22441 tgccatttgg tcagaagacg gttgcattta cccagctacc attgcttcaa ttgattttaa
    22501 gagagaaacc tgtgttgtgg tttacactgg atatggaaat agagaggagc aaaatctgtc
    22561 cgatctactt tccccaatct gtgaagtagc taataatata gaacaaaatg ctcaagaggt
    22621 aaggatacaa aaaaaaaaaa attcaatttc tggaagcaga gactagatga gaaactgtta
    22681 aacagtatac acagttgtca gtttgatcca ccgaggcatt aattttttct taatcacacc
    22741 cttataacaa aaacctgcat attttttctt tttaaagaat gaaaatgaaa gccaagtttc
    22801 aacagatgaa agtgagaact ccaggtctcc tggaaataaa tcagataaca tcaagcccaa
    22861 atctgctcca tggaactctt ttctccctcc accacccccc atgccagggc caagactggg
    22921 accaggaaag gtaaaccttc tatgaaagtt ttccagaaaa tagttaatgt cgggacattt
    22981 aacctctctg ttaactaatt tgtagctctc ccatgaaact tttgtagctt aaatacacaa
    23041 gaattttttg aaaaggaaat aagataatga tgcaaaatag ttaatttttt aaaaaaatgt
    23101 tagacactgc agtggatgca acaaaatact ttatatgaaa gatttatcca gttaactttt
    23161 gtggagtatt aggtattaga ctaataatta gcacacttac ttaagttaga aagtataata
    23221 atgcgccgga cgcggtagct cacgcctgta atcccagcac tttgggaggc caaggtgggc
    23281 ggatcacaag gtcaggagat cgagaccatc ctggctaaca cggtgaaacc ccatctctac
    23341 tgaaaataca aaaaaatttg ccgggcgtga tggcgggcac ctgtagtccc agctactcgg
    23401 gaggctgagg caggaggatg gtgtgaaccc cggaggcaga gcttgcagtg agtcaagatc
    23461 gtgccactgc actccaacct gggcgacaga atgagactcc atctcaaaca aaaaaacaaa
    23521 acaaaacaaa aaaaagtgta ataataattt atcattagct ggatgatatg ctgttgtttc
    23581 ccatgtcacc tgtataagat atgtaaaata agaacacatt atttacatct aatatagata
    23641 aaatcctgag gcgctctcag attgttttgt agagttcaaa tgtaaatatt gttttcattt
    23701 atggtccttt tggttataag taacagaaat caactctaaa aagattttta ttataggtta
    23761 gattatgtca tggaacctta aggcttgtcc ctttctagtt cttttgtgta aagcggtgat
    23821 ttcttccatg gagggaatgg tatttaggca attttttttt tttttcgaga tggagtcttg
    23881 ctctgtcgct caggctggag tgcagtggca ccatttcagc tcactgcaac ttccacctcc
    23941 tgggttcaag tgattctcct gcttcagcct cccaagtagc tgagattaca ggcacccgcc
    24001 accacacccg gcttattttg tatttttagt agagatgggg tttcaccatg ttggccaggc
    24061 tggtcttgaa ctcctgacct caagtgatct ccccaccttg gccttccaaa gtgctaggat
    24121 tacaggcgcc tagcctaggc agtcattttc aaaaaacaag catgactcac caaaagtttt
    24181 aagattttct gtgataatgt tcttattgag gcttacatta tattacagtt tcttgaatct
    24241 aaaatgatgt accctcttag gatatataca tcatgcttca ttggtctcag ggggctgatt
    24301 tttataagga gagatttgct agttttcaca atatgtcctc taagttggca tgtatagcta
    24361 aacaggcttt cataaaaata tacaatttag ttaatgaaat ttgggatata gtcttttatg
    24421 attgaaataa ttttgctaaa tagactgtct ctgatttatt aggtaatcac cactcttatt
    24481 ttgttttact tccttaatgt ctacatagaa aggaaatgag aaaaatccag aggttgtcat
    24541 ttgacttatg agtctgtttg acttcaggat ttggtacatg aaatttcact taatcttttt
    24601 gatatgtata aaacaaatat tctgggtaat tatttttatc cttttggttt tgagtccttt
    24661 ttattcctat catattgaaa ttggtaagtt aattttcctt tgaaatattc cttatagcca
    24721 ggtctaaaat tcaatggccc accaccgcca ccgccaccac caccacccca cttactatca
    24781 tgctggctgc ctccatttcc ttctggacca ccagtaagta aaaaagagta taggttagat
    24841 tttgctttca catacaattt gataattagc agaatagagg attgtaaaat gtcattgtag
    24901 aacatccctt gggccagatt ctaatgggta gaaatttgaa ctaaacctct gggttttgtt
    24961 tgtttttaat gcctttctgt tacccagatg cagtgctctt gtagtcccaa gtctaagctc
    25021 taggttgcct tctttcctgg cagaagttgg tgtctatgcc ataaggaggt agttcctgtt
    25081 agaagggatt taattatacc ttatataagg aattagtgtt tgcccttcta ggtatagttg
    25141 gatgttagct tctgatgtaa actggatttc tttttctttc tctctctttt tttttttttg
    25201 ttttggaggc agagttttgc ccttgtaccc caggctggag tgcagtggtg tgatctcagc
    25261 tcacagcaac ctccgcctcc tgggttcaag caattctgcc tcggcctccc aagtagctgg
    25321 gattacaggc gactgccacc acacccggct aatttttgtt ttattagtag agatggggtt
    25381 tcaccatgtt ggccagactg atcttgaact cctgacctca ggtgatccac ccgccttggc
    25441 ctcccaaagc gctgggatta caggcgtgag ctgccgcacc cagctgtaaa ctggatttct
    25501 aatggtagat ttttaggtat taacaataga taaaaagata ctttttggca tactgtgtat
    25561 tgggatgggg ttagaacagg tgttctaccc aagacattta cttaaaatcg ccctcgaaat
    25621 gctatgtgag ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt attaaggaaa agcatgaaag
    25681 tatttatgct tgattttttt tttttactca tagcttcata gtggaacaga tacatagtct
    25741 aaatcaaaat gtttaaactt tttatgtcac ttgctgtctt ttcgtcctcg ttaaatttaa
    25801 ttttgttggt cttttgttgt tattggttgg ttttctccaa atgctagcta tgttaagaaa
    25861 tttaaggcca ggtacagtgg ctcatgcctg taatcccggc attttagaag gctgaggcag
    25921 gaggatcact tgagctcagg agtttgagac cagtctgggc aacatagcaa gacctcgtct
    25981 ttgtttaggg gaaaaaaaag aaatttaagt aggagattat ataagcaaaa atacaattaa
    26041 tttccagcat tcactatata atataaatct ccagacttta cttttttgtt tactggatat
    26101 aaacaatatc tttttctgtc tccagataat tcccccacca cctcccatat gtccagattc
    26161 tcttgatgat gctgatgctt tgggaagtat gttaatttca tggtacatga gtggctatca
    26221 tactggctat tatatggtaa gtaatcactc agcatctttt cctgacaatt tttttgtagt
    26281 tatgtgactt tgttttgtaa atttataaaa tactacttgc ttctctcttt atattactaa
    26341 aaaataaaaa taaaaaaata caactgtctg aggcttaaat tactcttgca ttgtccctaa
    26401 gtataatttt agttaatttt aaaaagcttt catgctattg ttagattatt ttgattatac
    26461 acttttgaat tgaaattata ctttttctaa ataatgtttt aatctctgat ttgaaattga
    26521 ttgtagggaa tggaaaagat gggataattt ttcataaatg aaaaatgaaa ttcttttttt
    26581 tttttttttt tttttgagac ggagtcttgc tctgttgccc aggctggagt gcaatggcgt
    26641 gatcttggct cacagcaagc tctgccttct ggattcacgc cattctcctg cctcagcctc
    26701 agaggtagct gggactacag gtgcctgcca ccacgcctgt ctaatttttt gtattttttt
    26761 gtaaagacag ggtttcactg tgttagccag gatggtctca atctcctgac cccgtgatcc
    26821 acccgcctcg gccttccaag agaaatgaaa tttttttaat gcacaaagat ctggggtaat
    26881 gtgtaccaca ttgaaccttg gggagtatgg cttcaaactt gtcactttat acgttagtct
    26941 cctacggaca tgttctattg tattttagtc agaacattta aaattatttt attttatttt
    27001 attttttttt tttttttgag acggagtctc gctctgtcac ccaggctgga gtacagtggc
    27061 gcagtctcgg ctcactgcaa gctccgcctc ccgggttcac gccattctcc tgcctcagcc
    27121 tctccgagta gctgggacta caggcgcccg ccaccacgcc cggctaattt ttttttattt
    27181 ttagtagaga cggggtttca ccgtggtctc aatctcctga cctcgtgatc cacccgcctc
    27241 ggcctcccaa agtgctggga ttacaagcgt gagccaccgc gcccggccta aaattatttt
    27301 taaaagtaag ctcttgtgcc ctgctaaaat tatgatgtga tattgtaggc acttgtattt
    27361 ttagtaaatt aatatagaag aaacaactga cttaaaggtg tatgttttta aatgtatcat
    27421 ctgtgtgtgc ccccattaat attcttattt aaaagttaag gccagacatg gtggcttaca
    27481 actgtaatcc caacagtttg tgaggccgag gcaggcagat cacttgaggt caggagtttg
    27541 agaccagcct ggccaacatg atgaaacctt gtctctacta aaaataccaa aaaaaattta
    27601 gccaggcatg gtggcacatg cctgtaatcc gagctacttg ggaggctgtg gcaggaaaat
    27661 tgctttaatc tgggaggcag aggttgcagt gagttgagat tgtgccactg cactccaccc
    27721 ttggtgacag agtgagattc catctcaaaa aaagaaaaag gcctggcacg gtggctcaca
    27781 cctataatcc cagtactttg ggaggtagag gcaggtggat cacttgaggt taggagttca
    27841 ggaccagcct ggccaacatg gtgactactc catttctact aaatacacaa aacttagccc
    27901 agtggcgggc agttgtaatc ccagctactt gagaggttga ggcaggagaa tcacttgaac
    27961 ctgggaggca gaggttgcag tgagccgaga tcacaccgct gcactctagc ctggccaaca
    28021 gagtgagaat ttgcggaggg aaaaaaaagt cacgcttcag ttgttgtagt ataaccttgg
    28081 tatattgtat gtatcatgaa ttcctcattt taatgaccaa aaagtaataa atcaacagct
    28141 tgtaatttgt tttgagatca gttatctgac tgtaacactg taggcttttg tgttttttaa
    28201 attatgaaat atttgaaaaa aatacataat gtatatataa agtattggta taatttatgt
    28261 tctaaataac tttcttgaga aataattcac atggtgtgca gtttaccttt gaaagtatac
    28321 aagttggctg ggcacaatgg ctcacgcctg taatcccagc actttgggag gccaaggcag
    28381 gtggatcacg aggtcaggag atcgagacca tcctggctaa catggtgaaa ccccgtctct
    28441 actaaaagta caaaaacaaa ttagccgggc atgttggcgg gcaccttttg tcccagctgc
    28501 tcgggaggct gaggcaggag agtggcgtga acccaggagg tggagcttgc agtgagccga
    28561 gattgtgcca gtgcactcca gcctgggcga cagagcgaga ctctgtctca aaaaataaaa
    28621 taaaaaagaa agtatacaag tcagtggttt tggttttcag ttatgcaacc atcactacaa
    28681 tttaagaaca ttttcatcac cccaaaaaga aaccctgtta ccttcatttt ccccagccct
    28741 aggcagtcag tacactttct gtctctatga atttgtctat tttagatatt atatataaac
    28801 ggaattatac gatatgtggt cttttgtgtc tggcttcttt cacttagcat gctattttca
    28861 agattcatcc atgctgtaga atgcaccagt actgcattcc ttcttattgc tgaatattct
    28921 gttgtttggt tatatcacat tttatccatt catcagttca tggacattta ggttgttttt
    28981 atttttgggc tataatgaat aatgttgcta tgaacattcg tttgtgttct ttttgttttt
    29041 ttggtttttt gggttttttt tgttttgttt ttgtttttga gacagtcttg ctctgtctcc
    29101 taagctggag tgcagtggca tgatcttggc ttactgcaag ctctgcctcc cgggttcaca
    29161 ccattctcct gcctcagccc gacaagtagc tgggactaca ggcgtgtgcc accatgcacg
    29221 gctaattttt tgtattttta gtagagatgg ggtttcaccg tgttagccag gatggtctcg
    29281 atctcctgac ctcgtgatct gcctgcctag gcctcccaaa gtgctgggat tacaggcgtg
    29341 agccactgca cctggcctta agtgttttta atacgtcatt gccttaagct aacaattctt
    29401 aacctttgtt ctactgaagc cacgtggttg agataggctc tgagtctagc ttttaacctc
    29461 tatctttttg tcttagaaat ctaagcagaa tgcaaatgac taagaataat gttgttgaaa
    29521 taacataaaa taggttataa ctttgatact cattagtaac aaatctttca atacatctta
    29581 cggtctgtta ggtgtagatt agtaatgaag tgggaagcca ctgcaagcta gtatacatgt
    29641 agggaaagat agaaagcatt gaagccagaa gagagacaga ggacatttgg gctagatctg
    29701 acaagaaaaa caaatgtttt agtattaatt tttgacttta aatttttttt ttatttagtg
    29761 aatactggtg tttaatggtc tcattttaat aagtatgaca caggtagttt aaggtcatat
    29821 attttatttg atgaaaataa ggtataggcc gggcacggtg gctcacacct gtaatcccag
    29881 cactttggga ggccgaggca ggcggatcac ctgaggtcgg gagttagaga ctagcctcaa
    29941 catggagaaa ccccgtctct actaaaaaaa atacaaaatt aggcgggcgt ggtggtgcat
    30001 gcctgtaatc ccagctactc aggaggctga ggcaggagaa ttgcttgaac ctgggaggtg
    30061 gaggttgcgg tgagccgaga tcacctcatt gcactccagc ctgggcaata agagcaaaac
    30121 tccatctcaa aaaaaaaaaa ataaggtata agcgggctca ggaacatcat tggacatact
    30181 gaaagaagaa aaatcagctg ggcgcagtgg ctcacgccgg taatcccaac actttgggag
    30241 gccaaggcgg gtgaatcacc tgaagtcggg agttccagat cagcctgacc aacatggaga
    30301 aaccctgtct ctactaaaaa tacaaaacta gccgggcatg gtggcgcatg cctgtaatcc
    30361 cagctacttg ggaggctgag gcaggagagt tgcttgaact gagaaggcgg aggttgcggt
    30421 gagccaagat tgcaccattg cactccagcc tgggcaacaa gagcgaaact ccgtctcaaa
    30481 aaaaaaagga agaaaaatat ttttttaaat taattagttt atttattttt taagatggag
    30541 ttttgccctg tcgcccaggc tggggtgcaa tggtgcaatc tcggctcact gcaacctccg
    30601 cctcctgggt tcaagtgatt ctcctgcctc agcttcccga gtagctgtga ttacagccat
    30661 atgccaccac gcccagccag ttttgtgttt tgttttgttt tttgtttttt ttttttgaga
    30721 gggtgtcttg ctctgtcccc caagctggag tgcagcggcg cgatcttggc tcactgcaag
    30781 ctctgcctcc caggttcaca ccattctctt gcctcagcct cccgagtagc tgggactaca
    30841 ggtgcccgcc accacacccg gctaattttt ttgtgttttt agtagagatg gggtttcact
    30901 gtgttagcca ggatggtctc gatctcctga ccttttgatc cacccgcctc agcctcccca
    30961 agtgctggga ttataggcgt gagccactgt gcccggccta gtcttgtatt tttagtagag
    31021 tcggggtttc tccatgttgg tcaggctgtt ctccaaatcc gacctcaggt gatccgcccg
    31081 ccttggcctc caaaagtgca aggcattaca ggcatgagcc actgtgaccg gcaatgtttt
    31141 taaatttttt aaatttaaat tttatttttt agagaccagg tctcactcta ttgctcaggc
    31201 tggagtgcaa gggcacattc acagctcact gcagccttga cctccagggc tcaagcagtc
    31261 ctctcacctc agtttcccga gtagctggga ctacagtgat aatgccactg cacctggcta
    31321 atttttattt ttatttattt attttttttt gagacagagt cttgctctgt cacccaggct
    31381 ggagtgcagt ggtgtaaatc tcagctcact gcagcctccg cctcctgggt tcaagtgatt
    31441 ctcctgcctc agcctcccaa gtagctggga ttagaggtcc ccaccaccat gcctggctaa
    31501 ttttttgtac tttcagtaga aatggggttt tgccatgttg gccaggctgt tctcgaactc
    31561 ctgagctcag gtgatccaac tgtctcggcc tcccaaagtg ctgggattac aggcgtgagc
    31621 cactgtgcct agcctgagcc accacgccgg cctaattttt aaattttttg tagagacagg
    31681 gtctcattat gttgcccagg gtggtgtcaa gctccaggtc tcaagtgatc cccctacctc
    31741 cgcctcccaa agttgtggga ttgtaggcat gagccactgc aagaaaacct taactgcagc
    31801 ctaataattg ttttctttgg gataactttt aaagtacatt aaaagactat caacttaatt
    31861 tctgatcata ttttgttgaa taaaataagt aaaatgtctt gtgaaacaaa atgcttttta
    31921 acatccatat aaagctatct atatatagct atctatgtct atatagctat tttttttaac
    31981 ttcctttatt ttccttacag ggtttcagac aaaatcaaaa agaaggaagg tgctcacatt
    32041 ccttaaatta aggagtaagt ctgccagcat tatgaaagtg aatcttactt ttgtaaaact
    32101 ttatggtttg tggaaaacaa atgtttttga acatttaaaa agttcagatg ttaaaaagtt
    32161 gaaaggttaa tgtaaaacaa tcaatattaa agaattttga tgccaaaact attagataaa
    32221 aggttaatct acatccctac tagaattctc atacttaact ggttggttat gtggaagaaa
    32281 catactttca caataaagag ctttaggata tgatgccatt ttatatcact agtaggcaga
    32341 ccagcagact tttttttatt gtgatatggg ataacctagg catactgcac tgtacactct
    32401 gacatatgaa gtgctctagt caagtttaac tggtgtccac agaggacatg gtttaactgg
    32461 aattcgtcaa gcctctggtt ctaatttctc atttgcagga aatgctggca tagagcagca
    32521 ctaaatgaca ccactaaaga aacgatcaga cagatctgga atgtgaagcg ttatagaaga
    32581 taactggcct catttcttca aaatatcaag tgttgggaaa gaaaaaagga agtggaatgg
    32641 gtaactcttc ttgattaaaa gttatgtaat aaccaaatgc aatgtgaaat attttactgg
    32701 actctatttt gaaaaaccat ctgtaaaaga ctggggtggg ggtgggaggc cagcacggtg
    32761 gtgaggcagt tgagaaaatt tgaatgtgga ttagattttg aatgatattg gataattatt
    32821 ggtaatttta tgagctgtga gaagggtgtt gtagtttata aaagactgtc ttaatttgca
    32881 tacttaagca tttaggaatg aagtgttaga gtgtcttaaa atgtttcaaa tggtttaaca
    32941 aaatgtatgt gaggcgtatg tggcaaaatg ttacagaatc taactggtgg acatggctgt
    33001 tcattgtact gtttttttct atcttctata tgtttaaaag tatataataa aaatatttaa
    33061 ttttttttta aattagctgt atctgtgatt gtatttcttt tttgcatatt attttgccct
    33121 ttggcccata ttttgatatg gatgccacca tagcattttg tgtatgtgca tgtgtattcc
    33181 cacttaatgt cacatttttc atgtctttac atattcttat ttttgtttgt ttttgagaca
    33241 gagtctcgct ctgctgccca cgctggagtg cagtggtgca atctcagctc actgcaacct
    33301 gtgctatccg ggttcaagcg gttctcgtgc ctcagccacg tgagtagttg ggattacagg
    33361 catgtggcac catgccccac taagttttgt atttttagta gagatggagt ttcaccatgt
    33421 tggccaggct ggtctcaaac tcctgccctc aagtgattcg accaccctgg cctcccaaag
    33481 tgctgggatt acagccgtga gccaccgcac acggcctctc tatttatttc tatacatagc
    33541 ttttcacatt atattatgtt tatatattgt ttatatctgt atttcctctt tcattagaga
    33601 aaaggtagta catcttattc ttcatggtgt ctacaatatc tggcagtttt tggaagtcaa
    33661 gcgtgagctt agagcataga ctggtgggat tgtcaaagaa gagggcaact ggaagagaac
    33721 tgtcagttat ttttggatca gtctttaatt catcatgacg ggttaggcat tagttgtatt
    33781 tcttgctaat tttgaagaag acttattaac aaatcctaca ttaggtaaat ggttttgaaa
    33841 gttgagttaa tcataatggt gtttgaccta ggactatttt taggccctat ttatcttaat
    33901 atcgaataat gaagcagctt cccccttaga tatagacaga aaacatcaaa gccaccacac
    33961 tacctggctg gatttatcct agtaataaaa tcaaaactga gctagttctc tggctttcat
    34021 tgtaataatt gtccttgtgg ttgtaaggaa tctagatgaa aattacatgg tctgttctac
    34081 agccacagct gtacctacat tcagaagaca gacaaaagtt gctgtgtttg aagagatcct
    34141 tcattaaggg atcagacaga gattactttg agacatattc taagtttaac ttttctgcag
    34201 ggttgccatt aacagaaata aactacagag ttaatttctt tttgtttttg atacagtcta
    34261 actctcaccc aagctggagt gcagtggcgc aatttcagct cactgcaacc tctgcctccc
    34321 aggttcaagc aattctcctg cctcagcctc ccgagcagct gggactacag gcatgtgcca
    34381 ctatgcctgg ctaatttttg tatttttagt agtagagacg tggtttcgcc acgttggcca
    34441 ggctggtctg gaactcctga ccccaggtaa tccacctgcc tcggcctccc aaagtgctgg
    34501 gattacaagc ttgagccact acgcctgacc cagagttaac tttttaaaaa agtttttatg
    34561 aacttaagtc ttgtgatgtt tgaaataatg gattcaattt agacatcaaa ttccagaagt
    34621 tactaagagc agctgggcgc ggcagctcac acctgtaatc ccagcacttt gggaggccga
    34681 ggcgggtgga tcacctgaga tcaggagttc cagaccagcc tggccaacat agtaaaaccc
    34741 tgtctctact aaaaatacaa aaattagccc ggcatggtgg cacgcgcctg tagtcccagc
    34801 tacttgggag gctgaggcag gagaattgct tgaacccggg aggtggaggt tgtggtgagc
    34861 cgagattgtg ccactgtact caagcctggg ctaaaaagcg agactccgtc tcaaaaaaaa
    34921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aacaaaacac gttactaaga
    34981 gcaactctgg gccaggcacg gtggcttaca cctgtaatcc cagcattttg ggaggacgag
    35041 acaggcggat cacttgagcc caggagttca ag
//

