LOCUS NG_008691 35072 bp DNA linear PRI 16-AUG-2009 DEFINITION Homo sapiens survival of motor neuron 1, telomeric (SMN1) on chromosome 5. ACCESSION NG_008691 VERSION NG_008691.1 GI:209413713 KEYWORDS RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Johan den Dunnen. The reference sequence was derived from AC139834.2 and AC044797.5. Summary: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants encoding distinct isoforms have been described. [provided by RefSeq]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-15907 AC139834.2 169551-185457 15908-35072 AC044797.5 32834-51998 FEATURES Location/Qualifiers source 1..35072 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="5" /map="5q13" STS 4635..4740 /standard_name="D5S1556" /db_xref="UniSTS:150384" gene 5001..33072 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /note="survival of motor neuron 1, telomeric" /db_xref="GeneID:6606" /db_xref="HGNC:11117" /db_xref="MIM:600354" mRNA join(5001..5244,18899..18970,21449..21568,22418..22618, 22778..22930,24718..24813,26126..26236,32001..32054, 32499..33072) /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /product="survival of motor neuron 1, telomeric" /transcript_id="NM_000344.3" /db_xref="GI:196115055" /db_xref="GeneID:6606" /db_xref="HGNC:11117" /db_xref="MIM:600354" exon 5001..5244 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /inference="alignment:Splign" /number=1 CDS join(5164..5244,18899..18970,21449..21568,22418..22618, 22778..22930,24718..24813,26126..26236,32001..32051) /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /note="isoform d is encoded by transcript variant d" /codon_start=1 /protein_id="NP_000335.1" /db_xref="GI:4507091" /db_xref="CCDS:CCDS34181.1" /db_xref="GeneID:6606" /db_xref="HGNC:11117" /db_xref="MIM:600354" exon 18899..18970 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /inference="alignment:Splign" /number=2 exon 21449..21568 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /inference="alignment:Splign" /number=3 exon 22418..22618 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /inference="alignment:Splign" /number=4 STS 22452..22584 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /standard_name="SMN1" /db_xref="UniSTS:253711" exon 22778..22930 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /inference="alignment:Splign" /number=5 exon 24718..24813 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /inference="alignment:Splign" /number=6 STS 25607..25729 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /standard_name="D5F151S1" /db_xref="UniSTS:156650" exon 26126..26236 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /inference="alignment:Splign" /number=7 STS 31844..32045 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /standard_name="D5S2797" /db_xref="UniSTS:474072" exon 32001..32054 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /inference="alignment:Splign" /number=8 exon 32499..33072 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /inference="alignment:Splign" /number=9 STS 32666..32854 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /standard_name="D5S2798" /db_xref="UniSTS:474073" STS 32712..32974 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /standard_name="STS-U18423" /db_xref="UniSTS:106" STS 32827..33008 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /standard_name="D5S2463" /db_xref="UniSTS:61210" STS 32866..32988 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /standard_name="A006I11" /db_xref="UniSTS:8893" STS 32866..32988 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /standard_name="G20836" /db_xref="UniSTS:8892" STS 32895..33008 /gene="SMN1" /gene_synonym="BCD541; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541" /standard_name="D5S1946" /db_xref="UniSTS:61211" ORIGIN 1 tctgattggt gagcgatggt ggtaggtaaa accagtctta gagtcatggc agttcatttt 61 agcagctatt aggtaaaact ggtcttaggg atacagaagg ctggttcagc agttggactt 121 gtggaaaatt taattcttga agcagatgct gtgtgccccg aatgcttctt ccccctggcc 181 cttcaactct gatttagttg agtatttcaa gaatgaccca atttatgtaa tcaactttca 241 caggtataca tgtcttaaac tttaaacaga tgttttgggt tttgttgttg ttgtttttga 301 gacggagtct cactctgttg tccaagctgg agtgtagtgg tgtgatctcg gctcactgca 361 acctccgcct ccagggtcaa gtgattctcc agcctcagcc tcctgaatag ctgggattac 421 aggcgcccgc caccacgccc agctaatttt tgtattttta gtagagatgg ggtggggttt 481 caccatgttg gccaggctgg tcttgaactc ctgacatcaa gtgttctgct cacctcagcc 541 tctgaaagtg ctgggattac aggcgtgagc cactgcgccc ggcagtcttt ccttcttttt 601 tttttttttt tttttttttt taatgacatg gggtcttact ttattactca ggctggtctc 661 aaacttctgg cctcaaggga tcttcccacc ttggcctccc aaattgctgg gattacaggc 721 ataagtcatc atgcctggct acaaacagat attttcaata agaggataaa agttcatttc 781 cccatacttt gctaacatca aatgttatta attcctaata gttttgccaa actgagagga 841 aaatggtatg ttagtttttc tgggttttct ttctttttaa ttttttttct tttttattca 901 tcgcaacact attcacgatt tttttatttt ttattttatt tatttatttt tttttttttg 961 agacaaggtc tccctatgtt gcccaggctg gtcttgtacc cctgggctca aaggatcctc 1021 ctgcctcagc ctcccaaagt gctaggatta caggcatgag tcaccacgcc tggttcacaa 1081 tttctttttg tttttaccaa aggcaggtat attcctgaaa ttttttgttt ttttgttttt 1141 tttttgagat gaagtctcac cctgtcactc agactggagt gcactggcac gatctcagct 1201 cactgcaacc tccgcttcct aggttcaagc gattctcctg cctcagtctt caaagtagct 1261 aggattatag gcgccgcaac catgctcagc taatttttgt atttttagta gagacaggat 1321 ttcaccatgt tggccagggt gatctcaaat cctgacctca agtgatccgc ctgcctcagc 1381 ctcccaaagt gctgggatta ctggcatgag ccaccgtgcc aggccctgaa atgttatctt 1441 agttattaat ttgcaattcc ttggctctag aggttgggca tcttctcaga tctctagtgg 1501 acatttggat tttctttttg gtgaactgtc cagtttttct ctctgcttta caatctttat 1561 tatatgcaat cttcacatgt aggtactacc atttttttag tttgtttttg aaacagcata 1621 ttgctctgtt gcccaggctg gagcacggtg gcaaaaacat ggcttactgc agcctttgac 1681 ctccttggct caagtactcc tcctgtctca gcctcctgag tagctggtac cacaagccca 1741 taccaccatg cccagctaat ttatttttgt agagatgggg cctgaccatg ttacttgggc 1801 tcaaatgatc ctctcccact cagcctccca aagtgctagg attacaggca tgagccacca 1861 tacttggccc tttttttttt tttttttttt ttttttttga gacagagtct tgctctgtct 1921 cacaggctgg tgtgcagtgg cacgatctca gctcattgca acctccacct cccagtttca 1981 agtgattttt gtgcctcagc ctccctagta gctgagatta caggcatgca ccaccatgcc 2041 tggctgactt tcatatcttt agtgttgcca tgttggctag gctggtctca aactcctgac 2101 ctcatgtgat ccacctgcct cggactccca cagtgctggg attacaggtg ttagccacca 2161 ccccgacatt atttgaaact tttattttat catgagagag ttccaggagt caactgaaga 2221 cagatttttg gtatgaaaat tacatatgca aaaagactga ttccagtaca tgaaattaaa 2281 ttcaacattt acattaaatg ccttcaaata tggtaaaatg gtttcttttg gcagtttacc 2341 tcattatgtt ttgaatgatt tgtctatcat atgaaataac ttttataaat atagtaactc 2401 aggcctgggc acagcggctc aagtgggagg actgcttaag caaccgagtt tgagaccagc 2461 gtggacaaca tggggagacc ccttctctcc caaaaaatag ctgagcatgg cagcgcactg 2521 ttaaaggaaa cagagtttct ttggtgggtg attaaaatgt tctggagtta gatagtggtg 2581 atggttgcac aaccttgtga atatattaag gtttccgctc aatctaccat tcaattgtac 2641 tctctaaaat gattaattct atagtatatc aattatatct ctaaataata aaaacaaaaa 2701 gaaatggctg ggtgcggtgg ctcatgcctg taatcgcagc actttgggag gctgaggcgg 2761 gcggatcaca aggtcaggag tttgagacca acctgaccaa catggcaaaa ccccgtctct 2821 actaaaaata caaaaattag ctgggcgtgg tggcacacgc ctgtaatccc aggtactcgg 2881 gaagctgaga caggagaatc acttgaaccc gggaggcaga ggttgcagtg agccactgca 2941 ctccagtctg ggtggcagag cgagactccg tctcaaaaag aaaaaaatta aaaaacaaaa 3001 agaaacctgg ttctatattt tgtttaaatt tattttttta accatcatgt aatatgtcca 3061 cgtaatttgt ttaaattttg acatcaaatg caattgtgag aatttttatg attcagaaaa 3121 atctaagcaa gctttataaa aacatacttt tttttttact tttttttttt tttctgagac 3181 acagcctcac tctgtcgccc aggctggagt gcaggttttc atgtttatct gtgagatgta 3241 cctttggcac attactttcc tgacatgaga tttaaaattt ttttttttat cttgtgacaa 3301 tttaactttt ttgacacata aaaattgtac atatttattt gtttgagatg gagtcgcact 3361 ctgtcactca ggctggagtg cagtggcgtg atcttggctc actgcaacct ccgcctcccg 3421 agttcaagag attctcctgc ctcagcctcc caagcagctg tcattacagg cctgcaccac 3481 cacacccggc tgatttttgt atttttagga gaaacagggt ttcaccatgt tggccaggct 3541 ggtcttgaac tcctgacctc aagtgatcca cccaccttgg cctcccaaag tgctgggatt 3601 ataggcatga gccaccgtac cagaccccta aaaattgtat atatttaagg tgtaccattt 3661 gatgtttaga tatacattgt gaaatgatta cattccacat attacctcta cggagttacc 3721 atttttgtac acttggtcaa catcatccca ttctcccctt cctccacaga tatttcttgt 3781 atactatata gaagccaagg gtattttggg ggaagagctc aaagttcctt tcgtggagtt 3841 aaaaatatat atatactatg tacatataag ccatttagca accctagatg cttaataaag 3901 aatactggag gcccggtgtg gtggctcaca cctgtaatcc cagcactttg ggaggccgag 3961 gcggtcggat tacgaggtca ggagttcaag accagcctgg ccaacatggt gaaaccccat 4021 ctttactaaa aatacaaaaa ttagccgggt gtggtggtgg gcgcctgtaa tcccagctac 4081 tcggggggct gaggcaggag aattgcttga acctgggagg cagaggttgc agtgagctga 4141 gatcacgcca ctgcattcca gcctgggtga cagagcaata ctctgtcgca aaaaaaaaaa 4201 agaatactgg aggctgggcg aggtggctca cacctgtaat cccagcattt tgggatgcca 4261 gaggcgggcg gaatatcttg agctcaggag ttcgagacca gcctacacaa tatgctccaa 4321 acgccgcctc tacaaaacat acagaaacta gccgggtgtg gtggcgtgcc cctgtggtcc 4381 tagctacttg ggaggttgag gcgggaggat cgcttgagct cgggaggtcg aggctgcaat 4441 gagccgagat ggtgccactg cactctgacg acagagcgag actccgtctc aaaacaaaca 4501 acaaataagg ttgggggatc aaatatcttc tagtgtttaa ggatctgccg ccttccttcc 4561 tgcccccatg tttgtctttc cttgtttgtc tttatataga tcaagcaggt tttaaattcc 4621 tagtaggagc ttacatttac ttttccaagg gggaggggga ataaatatct acacacacac 4681 acacacacac acacacacac acacacacac tggagttcga gacgaggcct aagcaacatg 4741 ccgaaacccc gtctctacta aatacaaaaa atagctgagc gtggtggcgc acgcctatag 4801 tcctagctac tggggaggct gaggtgggag gatcgcttga gcccaagaag tcgaggctgc 4861 agtgagccga gatcgcgccg ctgcactcca gcctgagcga cagggcgagg ctctgtctca 4921 aaacaaacaa acaaaaaaaa aaggaaagga aatataacac agtgaaatga aaggattgag 4981 agaaatgaaa aatatacacg ccacaaatgt gggagggcga taaccactcg tagaaagcgt 5041 gagaagttac tacaagcggt cctcccggcc accgtactgt tccgctccca gaagccccgg 5101 gcggcggaag tcgtcactct taagaaggga cggggcccca cgctgcgcac ccgcgggttt 5161 gctatggcga tgagcagcgg cggcagtggt ggcggcgtcc cggagcagga ggattccgtg 5221 ctgttccggc gcggcacagg ccaggtgagg tcgcagccag tgcagtctcc ctattagcgc 5281 tctcagcacc cttcttccgg cccaactctc cttccgcagc ctcgggacag catcaagtcg 5341 atccgctcac tggagttgtg gtccgcgttt ttctacgtct tttcccactc cgttccctgc 5401 gaaccacatc cgcaagctcc ttcctcgagc agtttgggct ccttgatagc gttgagtgga 5461 ggccctgccg cgacttggca gtagcttatt ttgttcactc ctctctggct ggtgtggggg 5521 aggtgggggc attaggccag ggtgaagcag gggaaccact taggagtctg ttaagatgat 5581 ctgaacttca gaacaagatg ttattaacag agtgaaagta tttggattct gggtatattt 5641 tgaaatcgga ggcaacaggt ttttcagata gattcgataa cggaggttat cctgaatagt 5701 tgaaaagata aagttgcctt ttgctgaggt gggaaagaga agattgccag tagagcaggt 5761 ttctcaggag ttcagtcttg ggcatagcat ggtaggggtg aatttggctg gagtgagttg 5821 gagagtagga gaagagaaat ccaaggcaac atttgaccag cctgggcaac atagtgtgac 5881 tccgagtctg caaaaattag acgggtgttg tggtgcgcgt ctgtggtctc agctacctgg 5941 aaggttcagg ccttggaagg ctcagggagg tggaggctgc agtgatctgt gattgcgcct 6001 ctgcactcca gcctgggcga cagagccaga ccctgtctta aaacaaaata aacggccggg 6061 cgcggtggct caagcctgta atcccagcac tttgggaggc cgaggcggcc ggatcacaag 6121 gtcaggagat cgagaccatc ctggctaaca cggtgaaacc ccgtctctac tacaaataca 6181 aaaaattagc cgggcgtggt gacgggcgcc tgtagtccca gctactcggg aggctgaggc 6241 aggagaatgt catgaagccg ggaggcggag cttgcagtga gccgagatcg cgccactgca 6301 ctccagcctg ggcgatagag caagactccg tctcaaataa ataaataaat aaataaataa 6361 ataataaaaa catcggtagg catatttcaa ggaattctat ttaaaaaaaa tttttttaga 6421 gacaagttcg ctctctgtgg cccaggctgg agtacagtgg catgatccta gcccatggca 6481 gcgttgatct cttggcctca agcgaccctc ctttggagtc gctgggccta aaggagtgag 6541 ccaccacgaa attttattat aaatggaggg tagagaaatt gggcaataaa tggaggggga 6601 agtgagttaa gaggaatttt aattatgtgt gtgtggtttt aaaagagggg ggtcttgctc 6661 tgttgcccag gctgctgggg tgccagtggc gcaatcatga atcactacag ccttggactc 6721 ctggcctcaa gctatcctcc cacctctgcc tcccaaagta ctgggattac tagtgtgagc 6781 cactgcacta agataggagc aacatgtttc agcatgtttg tgggttgata ggaaagatga 6841 gaatgggaaa gttgatgtcg gaaagaagac aatggctaga gcaatgtcct agagtaggta 6901 agaagggatg gatttggcct ttgttggaaa cattagcggt tcttttggtg acagctatat 6961 agttaacaca tctatgatac gtgaatgggc agataggatg gcaggagatt ttgaaagttc 7021 tcttgattct tactgttctc ttagtgaaag aagcaaggtt atcagctaga agctgggatg 7081 ggagaggaaa gagaagatgg gaagtagata gttctttaga agagtgggca agggttggac 7141 tagggaagtt tagtggaaat attgctaggc aacataaaga gcctacttga gattcgtggt 7201 catgagttga aggagaccag acagcaagat tgtgtatgag ggcacccaca gagtaaatgg 7261 agagttgaaa ttaatgcagt tgtgatttta ccacgtggat atgaagaagt gagggggaga 7321 agtacaaagg agttctctta atgattgacc atggaattta agctggctaa gaaaggaagt 7381 gagaggccgg gcgcggtggc tcacgcctgt aatcccagca ctttgggaga ctgaggtggg 7441 tggattacct gaggtcagga gtttgagacc aacctggccg atatggcgaa accccatctc 7501 taataaaaat acagaaaaat tagccgggaa tggtggcagg tgcctgtaat cccagctact 7561 caagaggctg tggcaggagt atcccttgga cccaggaggt ggaggttgca gtgagccgag 7621 atcacgccac tgtactccag cctggacgat atagtgagac ttcacctcaa aaaaaaaaaa 7681 aaaagaaagg aagtgaggat tttaagaccc tgagagacag tttaaaaagt gggaggatcg 7741 gccgggcgct gtggctgaca cctgtaatcc cagcactttg ggaggccgag ttgggcagat 7801 cacaaggtca ggagttcgag accagcctgg ccaatatggt gaaaccttgt ctctactaaa 7861 aatacaaaaa ttagccgggc atggtgtcac gtgtctataa tcccagctac tcgggaggct 7921 gaggcagaaa aattgcttga acctgggagg cagaggttgc agacagctga gatcactcca 7981 ttgcactcca gcctgggcaa caagagcaaa actttgtctt taaaaaaaaa aaaaaaaaaa 8041 gaatacaaaa attagccggg cgtggtggcg cgtgcctata atcccagcta cttgggaggc 8101 tgaggcagga gaatcagttg aacacgggag gcgaggtttg cagtgagccg agattgcgcc 8161 actgcactcc agcctgggcg acagagcagg actcctcttg gaaaaaaaaa attagctggg 8221 catggtggca ggtgcctgta gtctcagcta ctagggaggc tgaggcagga aaatcacttg 8281 aacccgggat gtggagtttg cagtgacccg agatcgtgcc actgtactcc atcctgggcg 8341 acaaaatgag actctgcctc aaaaaaaaaa aaaaaaaaaa aaaaagtggg aggatcaatg 8401 tactgccagt cctaatgaag tggaatgatt gtccccatca aatcactagt aggagtaagt 8461 tgcagagcct agaaggtgat ggttaagaga gtgggattct tgaaactgca tttatggaga 8521 ggttgtggtt attggttata ataaataaat acagttgaag tgagtgagta gctgagattt 8581 ggggatgtat cagttcattc ttacactgct acaaagacat acctgagacc aggtatttat 8641 aaagataaga ggtttaatca gctcacagtt ctgctgcctg tacaggcttc tcttgtggag 8701 gcctaaggaa acttacagtc atggtggaag gtgaagggga aacaagcaca gtcttcacat 8761 ggccagcagg agagagagag aagggggaag tgctacatac tttaaaacaa ccagatcttg 8821 tgagaacgct tatcaggaaa cagcacttgg ggatggtgct aaatcattag aaatcacccc 8881 catgatccag tcgcctccta ccatgcccac ctccaacact ggggatcaca attcagcatg 8941 agatttgggt aggaacacag agctgcacca catcagagga tgtacaagat tgtggtggag 9001 aggagtttag agacctgcaa atatagggta attgaaggga tcatctacat ggatatttaa 9061 atcaccaaaa attatgacag gagtagtgtt ggagagagaa ctgcgatgta aacattaagg 9121 aatgaggaag agtgactcgg taggctgtag gtgactgcaa taggaaacga taatagactg 9181 tgagtctggt gacaagattt tccttctttc tttttttccc cccccccgag acagggcctc 9241 tttttgttgc ccaggtggga gtgcagtggc gcgatcacgg ctcactacaa cctcctccca 9301 agctcaaggg attctcccac ttcagcctct caagtagctg gaactacagg tgctgaccac 9361 catgcctggc tactttttgt caggattttc aaggctggga attttgagag gggaatggag 9421 gagaataatc tgaaagtgca agtaaggagc agggaagatt tcttttttct tttttttttt 9481 tttttttgag tcggagtctg gctcagtcgc ccaggctgga gtgcagtggc gagatctccg 9541 ctcactgcaa gctccgcctc ccgtgttcac gccattctcc tccttcagcc tcccgagtag 9601 ctgggactac aggcgcccgc caccacgccc agctaattgt ttttttgtat ttttagtaga 9661 gacggggttt caccgtgtta gccaggatgg tctcaatctc ctgactttgt gatccgccca 9721 ccccggcctc ccaaagcgct tgggattaca ggcgtgagcc accgcgccag ccagagcagg 9781 gaagatttct tccccacatc tccagtaggt acagtgatat gaagtgtgtg gaggagaaaa 9841 gaggaaacat ctatcatttg agatggctgc gaaaggaaaa ggcatcctca gggagctaga 9901 ttttacttag agcaagaaat gaagggatga ttcagaggtt aaaagagtgg attttatgaa 9961 ttactcaagg gagcacagtg gaagtttcag gaagtggtag gagaaggtag aagatggcag 10021 ggtgttggga ataatttgag aaatctgagc tactggaaat gactgagaat cagatataaa 10081 ggcagtcctg gtggtccgtt ctggctgccg ttgctgtgta acgaatctgc caaaacttag 10141 tggcttgaaa caacaaagaa cattttatta tctctcattg tttctgtggg ttaggaattt 10201 gtgagagccg tgctgggcag ttttcgtgcg gctgtctcgt ggttgcacct acatagttgc 10261 tagagctaca gtagctgggg actgagcagc tagggattgg caggctatct ctttttttca 10321 tgtagtctca tgaagatttc tttatgtggt ttcaatgtgt gggctggttt ggatttcctt 10381 atagcatggt ggcctcagtt ggattgctgt tttgtgatcc ttttcatccc tccttgtcct 10441 gtccccagac aaccactgat ctactttctg tcaccataga ttagcctgca tttttaagaa 10501 tttttataaa cgtggaatga tagagtacct tttttgtcac gtttctttta tttatcatag 10561 ctattttgat tttcatccat tttattgctg agtagtatcc cattgcatgt atatactata 10621 ctgtattcat tcgcttgctt gtgaacattt gggctttttc cagtttggga ctgttaacaa 10681 gtagagccac tatgaatatt agtgtataag acttcatata gccaaggctg gcagatcgct 10741 tgagcccagg agtttgagac cagcctggga aacatggtga aacctctatt tttattttaa 10801 aatcaaaaat taaaaatttt ctataaaaaa ttttaaagaa gactttgtat agacatacgc 10861 tttcattttt cttgagtgaa tacttaggtc tcagggtaga tgtattttaa gtctttaagg 10921 agctgtcaaa ctcttcctca aagtggtggt tgtaccatgt tactttttaa tataacagag 10981 attaattgag caaagaaaaa ttcaaaagtt ggacagcccc cacaactaaa taggttcaga 11041 acagctcccc cattttgcat tttgaccagc aatgtatgaa agttccattt gctcagtgtc 11101 cctgcaaaca cctggtatgg tcagtctttt taattttagg cattataata gatatagtgg 11161 cttcttgtga ttttaattag catttcctaa tgaccagtgc tgctgttgat catttcatga 11221 gtgtatttgc catccgtata tcttttttgg tgaagtgtct attcaaatca tttgggtttt 11281 tttttttttt gttttttttt tttggagaca gtgtctcact ctgtcaccca ggctgttgtg 11341 cagtggtgca atcacacagc ctactgcagc ctccacctcc tgcgctcagt cttcttgtct 11401 cagccttctg agtagctgaa attacgagca cacgccacaa tgcctggcta attttttaaa 11461 attttgtaga aacaaggtct cattatgttg cctgggcttg tcgtgaactc ctgggctcaa 11521 gcaatcttcc tgcctcagcc tcccaaagat tgggattgca agtatgagcc actgcacccg 11581 gccaacttac ccatctttta attgaatttt tttgttgttg aggtttgaga gttcttcatg 11641 tttgctgggt acaatatctt tatcagatag gtaacttgca tgtattttct cccggtttac 11701 actttggttt ttcattttgt taacaacgtc tttttaagaa cagaaaatct taattttgct 11761 gaaatctaat ttttcagttt tttctttgat ggttttgaga gaggaggtaa aaaaagacta 11821 ggtaagccga tagttagaca gagtcctcgg tagaacttcc cttctaacaa aaagcagccc 11881 aagaaatcac ttctcttcta acaaggagca gcctggaaga tcgggctgta aacatgtata 11941 aggaagcagc tctggcacag agggggagct tcctgggtaa tcagcaagct tcacatacgt 12001 aaggtgggta tgtgaagtaa acacagtatg tgaagtaaac acagtggacc ttagtacata 12061 ctcagataag gaagctggaa gcttgcatgt tgtgagttgt tggggttgcc tgcagctgca 12121 cggagagaaa ggggtacctg gggccaggca tgtccaccat ggtggctcca cctcccctta 12181 tttagcacat gcacaatagg aaagagataa gcaatgtgga gtagctcagg ccaaggacct 12241 gcctgcataa taaaaggttg gggtggggga tgccagagat tcacgctctg tgcagatggc 12301 aacacctggt cctaactggt tttttgctcc ctatgtgtag ataagctacc cccttcccat 12361 tagctcattt ataaaaatgc ttgcatttca ctgtggaatg ggaactcttt tcaggacctc 12421 tctctgcagg agagagctag tctctttctt ttgcctatta aacttctgct ctagcctcac 12481 acccttggtg tgtcagcgtc cttgatttcc tcagcgtgag accaagaacc tcgggtgcca 12541 ccccaggcaa caaggccatt tcagtttgtt cttttgttat aggcaatcca tgatcacaga 12601 tttttctctc tttttttttt ttacacagtt tagagtttta gttttacact taggtctgta 12661 atccattttg tattaattct tatatgtggc tcagtgtagg tggaaatttg gtttgttttt 12721 gcataaggat ttccaatagt tttaccacca tttcttgaaa ctactatgct ttctctatta 12781 aaccacattt gtaactttag ttaaaatcag tcacatatat cacagggcta tttctgactc 12841 tcaattctgt tacattgtct attagtgtat attgatgtca gtactacact tttaattact 12901 attgcttcag ggtatgtctt gtaaaccaaa aataaaatta taggcccccc ccgcccctgc 12961 acaaccaact gaatggaccc atcctctcag ccaagggcat tccaaaatta acctgaaaaa 13021 ctagttcaag ccatgatggg aagggggagt tggacatgtc tcatcacacc ctactacctt 13081 ttggaattac tgatagaaca gactcttaaa gtctgaaaag aaacatttac aacctaccct 13141 ctctgaagcc tgctacctgg gagcttcatc tgcatgataa aaccttggtc tccacaaccc 13201 cttatggtaa cccaaacatt cctttctgtt gataataact ctttcaacta gttgccaatt 13261 agaaaatctt taaatcttcc tatgacctag aaacctccct acccccactt tgagttgtcc 13321 tgcctttcct gacagaactc atgtacatct tacatatatt gattgatgcc tcatgtctcc 13381 ctaaaatgta taaaacaaag ctgtacccca ccaccttggg gacatgtcat caggacctcc 13441 tgtggctgtg tcataggagc gtctttaact ttggcaaaat aaactttcta aattgattga 13501 aacctgtctt agctacttct ggtttacagt cttaaagtta gataatgtaa attgtccagc 13561 tttggtttat ttttgtcctt agtagttcca tataaatttt agaatcagct tttcaattta 13621 atacactact ttcctcttag atccacaatt aaatatattt gatgctaaca attctgtttt 13681 atgtttttcg tttttttttt ttgagacaag agtttcgctc ttgttgccca ggctggagtg 13741 cagtggcgcg atcttggctc accacaacct ccacctccca ggttcaagca attcttctgc 13801 ctcagcctcc cgagtagctg ggattacagg catgcgccac cacgcccggc taattttgta 13861 tttttagtag agacggggtt tcaccatgtt gatcaggctg gtcttgaact cctgacctca 13921 ggtgatccac ccacctcggc ctcccaaagt gttgggatta caggcgtgaa ccaccatgcc 13981 tggccagttc tgttattttt aaaacccaag tttccctggt catatcttgg ttggatgaag 14041 cgtattttca atagattacc ctggaaaggc tagtgagtac ggtattcttc tacattttag 14101 acttttctta gtcttgctac ttcaaggaca gctaggctgc atataaaatt cttggctcat 14161 actttttccc cataaatttc tatgagaaag tctaatgata actgattttc tttattttgt 14221 aacttagtct ttttgcttag aggctctctg aggatgggag ggggttcttc ctcccatccc 14281 taggaatttt tctttttttt aaattcctaa tcactagacc accaggaaga ttgtttgttt 14341 tgttttgttt ttattcttca gggaccccat ttatacatac gttaaataaa tactgtttgc 14401 caatgtatca accattttgc ttcttattta tttttgttcc tttggttctt tttcatggct 14461 ttgctttggt gctccttaga ttttcagtca gatgtatttg tccttgggta ccttgtaatc 14521 agtattacct tttcttctgt cgctttgttt tctgttcgtt ttgaaattac ttgtttcctg 14581 gtctggcaat aacagttgag atatgaggag tttgagctgc catctgtcta tgtatcttgc 14641 tttaagactg cactcttcta ttgatatcac tggccttgat tttgtgattt ctttatttct 14701 tcaggaccac ccttcatttt ctactgtttg cttccttttt ttttgagatg gagtctcact 14761 ctgtcactca ggctggagtg cagtgatctt ggctcattgc aacctctgcc tcccgggttc 14821 cagcaattct cctgcctcag cctcccaagt atctgggact acaggtgtgc accaccatgc 14881 ccggctaagt tttgtatttt taatagagac ggggttttgc cacattggca ggctggtctc 14941 aaactcctga tgtcaagtga tccacccacc ccacccacct ctgcatccca aagtgctggg 15001 attacaggaa tgagctgccg tgcccagcct cccccctacc cccctttttt tctttcgaga 15061 cagagattat aggtgtgagc cactggaccc agcctgtttt tattcctttt accaaatctc 15121 caaggaatat cttcccttcc aagtgcgaat gtaaccttaa gtcagttaac ctctttgtga 15181 ttacttttct tatctgcaaa gtgacttaat gatcttaagt actttttttt tttgagacag 15241 ggtctcactg tcaccctggc tggagtgcag tggcacgatc tctgatctcc actcactgca 15301 atctcctctt ccctggttca agcggccctc ccaccttagc cttctgggta gctgggacta 15361 cagatgtgaa ccaccacgcc cagctaattt ttgtactttt tgtagagatg gggttttgcc 15421 atgttgccca ggctgggatt attaagtact ttttatcata cagcaagatt gacattttat 15481 attggaatac atttgtctct atataacgga gattaacagg aaaatgacaa gcctgggtgc 15541 ggtggctcat gcctgtaatc ccagcacttt gggaggctga ggtgggagga tcacttgagg 15601 tcaggagttc gagaccagtt ttgccaagat gatgaaagcc catgtctact aaaaatacaa 15661 aaattagccc agcttgatgg tgggcgccta taatcccagc tatttgagag actgaggcag 15721 gagaatcact tgaacctggg cggcagaggt tgcagtgagc cgagatcatg ccactgcact 15781 ccagcctggg tggcatagcg agactcttgt ctcaagagaa aacaaaacaa aacaaaaaaa 15841 aaacaggaaa atgacaaaaa gtaatattac aactcagtga attttataac aaactttttt 15901 ggaattcatt gactaatact ataccaaatc caaaatactc tctagtatac caaatccaac 15961 tctaccctat agtataaatt ggattctatt tggacttgtc tcactaatcc ctcatacagt 16021 gtgttttatt ttttattgaa gtaaaaaaat ttgtcatttt aaccattttt aagtatatag 16081 ttcagtaata ttaagtatgt tcatgttgtt gcgcaataga tcttcggaag tttttcgtct 16141 tgcaacctga aactctaccc attagcaaat tcccatttct ccttacactt agcccttggt 16201 aatcatcatt cttttttttt tttttttgag atggagtttt actcttgttg cccaggctgg 16261 agtgcaatgg tgcaatctcg actcaccaca acctccgcct cccaggttca agcaattcta 16321 cctcagcctc ccgagtagct gggattacag tcatgcacca ccacgcccgg ctaattttgt 16381 atttttagta gagaaggggt ttctccatgt tgaggctggt ctcgaactcc tgacctcagg 16441 tgatctgccc acctcggcct cccaaagtgc tgggattaca ggcgtgagcc actgcgcctg 16501 gcccattctt tctaattcta taaatttgac tacttagtta ccttacataa ataaattctt 16561 atagttagtg ttatttttgc ttccatgcct tttttgttgt tgttcatgct cttacttgga 16621 atgcgttcta ttttgtctac ctatgcacat cctgttgggt tttttttttt tttgggggtt 16681 ttttttgttt ttttttgttt ttttttccca gacaaggtct caatttgtta cccaggctgg 16741 agtgcagcgg cgccatctcc actcactgca tcctcaactt cctgggccca ggtgatcctc 16801 tcgcctcagc ccctgcaggt agctgggact ataggcatgt gccaccatgc ccagctaaat 16861 ttggtttttt tgtttgtttg tttttgagac agagtctcac tctgtcaccc aggctggagt 16921 gcagtggcac aatctcagct cactgcaatc tctgccgccc gggttcaagt gattctcctg 16981 cctcagcctc ccaagcagct gggattacag gtgactgcca ccacgccagc taagttttgt 17041 agttttagta gagatggggt ttcaccttgt tggccatgct ggtctcgaac tcctgacctc 17101 gtgatctgcc tgcttctgcc tcccaaagtg ctggaattac aggcatgagc caccacgccc 17161 ggccagaatt tttgtatttt tagtagacac aaggttctta ccctgttgcc taggctggtc 17221 tggaagtcct ggactcaagc aattcacctg ccttggcctc ccaaaatgct gggattacaa 17281 gccaccatgc ccggcctaaa tcctgttgtt ttgttttgtt ttattttgtt ttgttttgtt 17341 ttgtttgttt tttgagacag agtctcgcta tgtctctcag gctgtagtgc agtggcgcga 17401 tcttggctca ctgccacctc tgcctcccag gttcaagtga ttctcctgcc tcagcctccc 17461 aagtagctgg gattacaggc atgtgctact atgtccggct aatttttgta tttttagtag 17521 agacagggtt tcaccatgtt ggccaggctg gtctcgaact cctgacctcg tgatccaccc 17581 acctcggcca cccaaagtgc tgggattaca ggcgtgagtg gtttttattt cttaggccgg 17641 tttcctccat atgatcttgc agtagacatt aatttctttc ctttttaatt aaaatactgt 17701 ttgtatttca cattttgatg tttgttaaga tttgttttat attgtttttt gttttgtctt 17761 gtgtgatagt cttaaatccc tagttagata ataactggag agtaccatgt ttctatatat 17821 ctctcagtga cttgcacagt gctagcagat agtgctaaaa aattatttat tattattatt 17881 attttgttat tgttgttgtt gttgttagac agggtcttcc tctgtcaccc aggctagagg 17941 gcaatgggat gatcatagct tactgcagcc tccaacaact gggctcatgt aattctcctg 18001 cctcagcttc ccaagtagct gggattacag gcatgagcca ccatgtctgg acaaaaatat 18061 ttccaggtgc agtggctcat gcctgtaatt cccacacttg ggaggccgag cgaggctgga 18121 ggatcacttg agcctaggag ttcaagacca gcttggctaa gatggcgaga ccccgtccct 18181 acaaaaaatt ttaaaaacta gccaggcatg gtggcatgca cctatattcc caactactca 18241 gtgggctgag gtgggagggt catttgaaca caggaatttg aggggagaaa aaaagaagag 18301 agaaagagaa gtgaaggaag gaagaaagga aggagggagg gagagaagaa agaaacgaaa 18361 gaaaggaaaa gaaaaggaag gaaagaaaat tggtaccagg aaagcaggaa agggaaatgg 18421 aagtaaaaaa ataataataa taataaaatg aaaattggtt agtcactatt aacaatttgt 18481 atccttataa tctggaaaca ttataatttc aaaagaaaaa atattctttg gatcataggt 18541 tctgaggtca gaacagcatt cccgtagtct agatgaagtc aagttttatc tgatcttaat 18601 tgaaataaat atagctggcc ttgaacaaat ctactcatgg tatgtggata ggaattaaat 18661 tgtaggggca ttcacttgat ggcattcatt cttagaacat ttacctatgt ctagcttttg 18721 gagtaaagtc acataacctc taaccaggta agtttcctgt ggctttattt aggattttaa 18781 atactcattt tcagtgtaat tttgttatgt gtggattaag atgactcttg gtactaacat 18841 acattttctg attaaaccta tctgaacatg agttgttttt atttcttacc ctttccagag 18901 cgatgattct gacatttggg atgatacagc actgataaaa gcatatgata aagctgtggc 18961 ttcatttaag gtatgaaatg cttgcttagt cgttttctta ttttctcgtt attcatttgg 19021 aaaggaattg ataacatacg ataaagtgtt aaagtacatg ttattcagtt ttcattttga 19081 agattagatg gtagtatgag ttagttaaat caggtgatat cctcctttag aagttgatag 19141 cctatatatg tcatcctttg tggaggcaat ttaaataaaa tttaaaacat ttattcctgg 19201 ctgggtatgg tggctcactc ctgtaatccc agcactttga gaggctgagg cgggtggatc 19261 acctgaggtc aggagtttga gaccagcctg gccaacatgg tgaaaccccg tctttactaa 19321 aaatacaaaa attagccaag catggtggca cgtgcctgta atcccagctg cttgggacac 19381 tgaggcagga gaattgcttg aacctggggg gcagaggttg caatgattgc accactgcac 19441 tccagcctgg gcgatagagt gagactccat ctcagaaaac gaacaaacaa tgtattcctt 19501 ttagtatttt tacattgtat caaactatgg aagtcctcta attgagatta ataagaaaaa 19561 gacaatctga attataattt taaacattta acaagcatgt agtaaaataa tgatgaagat 19621 aaatagcatt agtacagcaa ttaatatttg tagcatgctg acagtgctct gtgtgcgttt 19681 catatattaa attactctaa tcatcccaaa tcctgtaagt tgggtatcaa ttcaagtgtt 19741 cctattgggt aggaatatac agttctttta ggaaatgtag tatggttctg tgtctcaaac 19801 aggacactta cacagttggc caacatcatc accttctcca ttctctgaga tgtttagtct 19861 tactgagcac taaatatggg tcatcaatag tccagactac cttgagcaaa caatagtcca 19921 gactaccttg agcaaacaga gcatatactc atacagtgta taaagagcac caagcataca 19981 gatttcatgt ctttctcata gttactcttg taacatgagc taaagatcag acctctatgt 20041 cacctttgta actgatttct agattttttt ttttttttga gatggggtct tgccctgtca 20101 cccaggctgg agtgtagtgg cgtgatcatg cctcattgga gccttcaact catgagctca 20161 aacaatcctc ctacctcagc ttcctgagta gttgggacca caggtgtgtg ccaccacacc 20221 cagctcattt ttgtattctt tgtagagatg cagtctcacc ctgttgccca cgctggcctg 20281 gaactcctga gctcaaaaga tccctccgcc ttgaccttcc aaagtgctgg gattacaagc 20341 atgaaccact gcacccggcc tagattttta aatgtgcttt ccagtataca ctgaaactag 20401 aagtcgacta aagaattacc aagagaattc tataaaatag agattgaaat ggggctcgat 20461 gtgggatggg ttggtgatat tgcagggaga agtaatctga gtaaaggagg aaaagaactg 20521 atttgggaaa acgatagttt tagtagtgag tttgagtatg aattaagttg agattgaatt 20581 tgaattaagt tgaggttgaa tatgaattaa gttgaggttg agtttgaggt atgaattaag 20641 atgtgaaatt gatcattgga aatgttagat tgagaaaagt cacagctgga ttaatagctt 20701 cagaagtgtg tttgcagaca gttgcaacta aagtaataag aatagatggc cttggccggg 20761 cgcggtggct cacgcctgta atcccagtac tttgggaggc tgaggcgagc aaatcacgag 20821 gtcaggagtt caagaccagc ctggcccaca tggtgaaacc ccgtctttat taaaaataca 20881 aaaattagct gtgcacagtg gtgcacgcct gtaatcccag ctactcggga ggctgagaca 20941 ggagaatcgc ttgaacctgg gaggtggagg ttgcagtgag ctgagatcag tgtgactgca 21001 ctccagcccg gtgacagagt gagactctgt gtaaaaaaat aaaataaata aaataatggc 21061 cgtaagcaag taaagaagga tggccagctc ttattgggaa tgcctaaatc taaggcttga 21121 tcagaagtaa tgaaaccgtt ggggccctac attgctatga catccaaagg gccatgaata 21181 tcaggaagaa agataattaa cagggtctaa tgttacagag aggttgagag caaggagatt 21241 tgattaaaag ggtctttaga gctgatgtca ggtgtatgat gcctttaaga gcagttttta 21301 tagtgcaggg ggtggtcaaa agagaaaata ggtgctttct gaggtgacgg agccttgaga 21361 ctagcttata gtagtaactg ggttatgtcg tgacttttat tctgtgcacc accctgtaac 21421 atgtacattt ttattcctat tttcgtagca tgctctaaag aatggtgaca tttgtgaaac 21481 ttcgggtaaa ccaaaaacca cacctaaaag aaaacctgct aagaagaata aaagccaaaa 21541 gaagaatact gcagcttcct tacaacaggt tattttaaaa tgttgagatt taacttcaaa 21601 ggatgtctca ttagtcctta tttaatagtg taaaatgtct ttaacttaag tgattagtac 21661 agtgtttcta ttgacatata cttatacaac ttcaaaaaca actattaaat tttctgttat 21721 ttaggaacat gcatattagt catgaaagta taaagaatta gatgggaatg ataaatgcta 21781 aaatcaggac atgtgttcca tttgtgaatg gaaggcaggg agaaggtgcc gtttggaagg 21841 agtacccaag agccgtaagc tgaattggca gtgttttaca tcttaagctg agagatagat 21901 ttttttttcc cctttttctt taaaaactct aaaactgtta attccaagga acccagaagt 21961 ctaggtagat tatttctgct agttaaaagc agtagtcctg aaagctgaat attttggtgt 22021 cttttgagcc aactttagtt tcatcattac caagggggaa gagagctaac agttgatgag 22081 cacttgctct aggccagtcc agagtgctgg gcaccatacg cattttatct ccctcccgct 22141 attcacaaca aatatgggag gtagtttata ttatagccat ctaataagat ggggaaacta 22201 agactcaaag agattcagaa acttgtccat gattataaat gtaagagagt tggaattcag 22261 atttatgtat ttagacccca agcctttctc attacatcat tttgccttcc aaatctctac 22321 cctctatcct tcacctcccc actgatcaaa acgagatgat agtttgccct cttcaaaaga 22381 aatgtgtgca tgtatatatc tttgatttct tttgtagtgg aaagttgggg acaaatgttc 22441 tgccatttgg tcagaagacg gttgcattta cccagctacc attgcttcaa ttgattttaa 22501 gagagaaacc tgtgttgtgg tttacactgg atatggaaat agagaggagc aaaatctgtc 22561 cgatctactt tccccaatct gtgaagtagc taataatata gaacaaaatg ctcaagaggt 22621 aaggatacaa aaaaaaaaaa attcaatttc tggaagcaga gactagatga gaaactgtta 22681 aacagtatac acagttgtca gtttgatcca ccgaggcatt aattttttct taatcacacc 22741 cttataacaa aaacctgcat attttttctt tttaaagaat gaaaatgaaa gccaagtttc 22801 aacagatgaa agtgagaact ccaggtctcc tggaaataaa tcagataaca tcaagcccaa 22861 atctgctcca tggaactctt ttctccctcc accacccccc atgccagggc caagactggg 22921 accaggaaag gtaaaccttc tatgaaagtt ttccagaaaa tagttaatgt cgggacattt 22981 aacctctctg ttaactaatt tgtagctctc ccatgaaact tttgtagctt aaatacacaa 23041 gaattttttg aaaaggaaat aagataatga tgcaaaatag ttaatttttt aaaaaaatgt 23101 tagacactgc agtggatgca acaaaatact ttatatgaaa gatttatcca gttaactttt 23161 gtggagtatt aggtattaga ctaataatta gcacacttac ttaagttaga aagtataata 23221 atgcgccgga cgcggtagct cacgcctgta atcccagcac tttgggaggc caaggtgggc 23281 ggatcacaag gtcaggagat cgagaccatc ctggctaaca cggtgaaacc ccatctctac 23341 tgaaaataca aaaaaatttg ccgggcgtga tggcgggcac ctgtagtccc agctactcgg 23401 gaggctgagg caggaggatg gtgtgaaccc cggaggcaga gcttgcagtg agtcaagatc 23461 gtgccactgc actccaacct gggcgacaga atgagactcc atctcaaaca aaaaaacaaa 23521 acaaaacaaa aaaaagtgta ataataattt atcattagct ggatgatatg ctgttgtttc 23581 ccatgtcacc tgtataagat atgtaaaata agaacacatt atttacatct aatatagata 23641 aaatcctgag gcgctctcag attgttttgt agagttcaaa tgtaaatatt gttttcattt 23701 atggtccttt tggttataag taacagaaat caactctaaa aagattttta ttataggtta 23761 gattatgtca tggaacctta aggcttgtcc ctttctagtt cttttgtgta aagcggtgat 23821 ttcttccatg gagggaatgg tatttaggca attttttttt tttttcgaga tggagtcttg 23881 ctctgtcgct caggctggag tgcagtggca ccatttcagc tcactgcaac ttccacctcc 23941 tgggttcaag tgattctcct gcttcagcct cccaagtagc tgagattaca ggcacccgcc 24001 accacacccg gcttattttg tatttttagt agagatgggg tttcaccatg ttggccaggc 24061 tggtcttgaa ctcctgacct caagtgatct ccccaccttg gccttccaaa gtgctaggat 24121 tacaggcgcc tagcctaggc agtcattttc aaaaaacaag catgactcac caaaagtttt 24181 aagattttct gtgataatgt tcttattgag gcttacatta tattacagtt tcttgaatct 24241 aaaatgatgt accctcttag gatatataca tcatgcttca ttggtctcag ggggctgatt 24301 tttataagga gagatttgct agttttcaca atatgtcctc taagttggca tgtatagcta 24361 aacaggcttt cataaaaata tacaatttag ttaatgaaat ttgggatata gtcttttatg 24421 attgaaataa ttttgctaaa tagactgtct ctgatttatt aggtaatcac cactcttatt 24481 ttgttttact tccttaatgt ctacatagaa aggaaatgag aaaaatccag aggttgtcat 24541 ttgacttatg agtctgtttg acttcaggat ttggtacatg aaatttcact taatcttttt 24601 gatatgtata aaacaaatat tctgggtaat tatttttatc cttttggttt tgagtccttt 24661 ttattcctat catattgaaa ttggtaagtt aattttcctt tgaaatattc cttatagcca 24721 ggtctaaaat tcaatggccc accaccgcca ccgccaccac caccacccca cttactatca 24781 tgctggctgc ctccatttcc ttctggacca ccagtaagta aaaaagagta taggttagat 24841 tttgctttca catacaattt gataattagc agaatagagg attgtaaaat gtcattgtag 24901 aacatccctt gggccagatt ctaatgggta gaaatttgaa ctaaacctct gggttttgtt 24961 tgtttttaat gcctttctgt tacccagatg cagtgctctt gtagtcccaa gtctaagctc 25021 taggttgcct tctttcctgg cagaagttgg tgtctatgcc ataaggaggt agttcctgtt 25081 agaagggatt taattatacc ttatataagg aattagtgtt tgcccttcta ggtatagttg 25141 gatgttagct tctgatgtaa actggatttc tttttctttc tctctctttt tttttttttg 25201 ttttggaggc agagttttgc ccttgtaccc caggctggag tgcagtggtg tgatctcagc 25261 tcacagcaac ctccgcctcc tgggttcaag caattctgcc tcggcctccc aagtagctgg 25321 gattacaggc gactgccacc acacccggct aatttttgtt ttattagtag agatggggtt 25381 tcaccatgtt ggccagactg atcttgaact cctgacctca ggtgatccac ccgccttggc 25441 ctcccaaagc gctgggatta caggcgtgag ctgccgcacc cagctgtaaa ctggatttct 25501 aatggtagat ttttaggtat taacaataga taaaaagata ctttttggca tactgtgtat 25561 tgggatgggg ttagaacagg tgttctaccc aagacattta cttaaaatcg ccctcgaaat 25621 gctatgtgag ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt attaaggaaa agcatgaaag 25681 tatttatgct tgattttttt tttttactca tagcttcata gtggaacaga tacatagtct 25741 aaatcaaaat gtttaaactt tttatgtcac ttgctgtctt ttcgtcctcg ttaaatttaa 25801 ttttgttggt cttttgttgt tattggttgg ttttctccaa atgctagcta tgttaagaaa 25861 tttaaggcca ggtacagtgg ctcatgcctg taatcccggc attttagaag gctgaggcag 25921 gaggatcact tgagctcagg agtttgagac cagtctgggc aacatagcaa gacctcgtct 25981 ttgtttaggg gaaaaaaaag aaatttaagt aggagattat ataagcaaaa atacaattaa 26041 tttccagcat tcactatata atataaatct ccagacttta cttttttgtt tactggatat 26101 aaacaatatc tttttctgtc tccagataat tcccccacca cctcccatat gtccagattc 26161 tcttgatgat gctgatgctt tgggaagtat gttaatttca tggtacatga gtggctatca 26221 tactggctat tatatggtaa gtaatcactc agcatctttt cctgacaatt tttttgtagt 26281 tatgtgactt tgttttgtaa atttataaaa tactacttgc ttctctcttt atattactaa 26341 aaaataaaaa taaaaaaata caactgtctg aggcttaaat tactcttgca ttgtccctaa 26401 gtataatttt agttaatttt aaaaagcttt catgctattg ttagattatt ttgattatac 26461 acttttgaat tgaaattata ctttttctaa ataatgtttt aatctctgat ttgaaattga 26521 ttgtagggaa tggaaaagat gggataattt ttcataaatg aaaaatgaaa ttcttttttt 26581 tttttttttt tttttgagac ggagtcttgc tctgttgccc aggctggagt gcaatggcgt 26641 gatcttggct cacagcaagc tctgccttct ggattcacgc cattctcctg cctcagcctc 26701 agaggtagct gggactacag gtgcctgcca ccacgcctgt ctaatttttt gtattttttt 26761 gtaaagacag ggtttcactg tgttagccag gatggtctca atctcctgac cccgtgatcc 26821 acccgcctcg gccttccaag agaaatgaaa tttttttaat gcacaaagat ctggggtaat 26881 gtgtaccaca ttgaaccttg gggagtatgg cttcaaactt gtcactttat acgttagtct 26941 cctacggaca tgttctattg tattttagtc agaacattta aaattatttt attttatttt 27001 attttttttt tttttttgag acggagtctc gctctgtcac ccaggctgga gtacagtggc 27061 gcagtctcgg ctcactgcaa gctccgcctc ccgggttcac gccattctcc tgcctcagcc 27121 tctccgagta gctgggacta caggcgcccg ccaccacgcc cggctaattt ttttttattt 27181 ttagtagaga cggggtttca ccgtggtctc aatctcctga cctcgtgatc cacccgcctc 27241 ggcctcccaa agtgctggga ttacaagcgt gagccaccgc gcccggccta aaattatttt 27301 taaaagtaag ctcttgtgcc ctgctaaaat tatgatgtga tattgtaggc acttgtattt 27361 ttagtaaatt aatatagaag aaacaactga cttaaaggtg tatgttttta aatgtatcat 27421 ctgtgtgtgc ccccattaat attcttattt aaaagttaag gccagacatg gtggcttaca 27481 actgtaatcc caacagtttg tgaggccgag gcaggcagat cacttgaggt caggagtttg 27541 agaccagcct ggccaacatg atgaaacctt gtctctacta aaaataccaa aaaaaattta 27601 gccaggcatg gtggcacatg cctgtaatcc gagctacttg ggaggctgtg gcaggaaaat 27661 tgctttaatc tgggaggcag aggttgcagt gagttgagat tgtgccactg cactccaccc 27721 ttggtgacag agtgagattc catctcaaaa aaagaaaaag gcctggcacg gtggctcaca 27781 cctataatcc cagtactttg ggaggtagag gcaggtggat cacttgaggt taggagttca 27841 ggaccagcct ggccaacatg gtgactactc catttctact aaatacacaa aacttagccc 27901 agtggcgggc agttgtaatc ccagctactt gagaggttga ggcaggagaa tcacttgaac 27961 ctgggaggca gaggttgcag tgagccgaga tcacaccgct gcactctagc ctggccaaca 28021 gagtgagaat ttgcggaggg aaaaaaaagt cacgcttcag ttgttgtagt ataaccttgg 28081 tatattgtat gtatcatgaa ttcctcattt taatgaccaa aaagtaataa atcaacagct 28141 tgtaatttgt tttgagatca gttatctgac tgtaacactg taggcttttg tgttttttaa 28201 attatgaaat atttgaaaaa aatacataat gtatatataa agtattggta taatttatgt 28261 tctaaataac tttcttgaga aataattcac atggtgtgca gtttaccttt gaaagtatac 28321 aagttggctg ggcacaatgg ctcacgcctg taatcccagc actttgggag gccaaggcag 28381 gtggatcacg aggtcaggag atcgagacca tcctggctaa catggtgaaa ccccgtctct 28441 actaaaagta caaaaacaaa ttagccgggc atgttggcgg gcaccttttg tcccagctgc 28501 tcgggaggct gaggcaggag agtggcgtga acccaggagg tggagcttgc agtgagccga 28561 gattgtgcca gtgcactcca gcctgggcga cagagcgaga ctctgtctca aaaaataaaa 28621 taaaaaagaa agtatacaag tcagtggttt tggttttcag ttatgcaacc atcactacaa 28681 tttaagaaca ttttcatcac cccaaaaaga aaccctgtta ccttcatttt ccccagccct 28741 aggcagtcag tacactttct gtctctatga atttgtctat tttagatatt atatataaac 28801 ggaattatac gatatgtggt cttttgtgtc tggcttcttt cacttagcat gctattttca 28861 agattcatcc atgctgtaga atgcaccagt actgcattcc ttcttattgc tgaatattct 28921 gttgtttggt tatatcacat tttatccatt catcagttca tggacattta ggttgttttt 28981 atttttgggc tataatgaat aatgttgcta tgaacattcg tttgtgttct ttttgttttt 29041 ttggtttttt gggttttttt tgttttgttt ttgtttttga gacagtcttg ctctgtctcc 29101 taagctggag tgcagtggca tgatcttggc ttactgcaag ctctgcctcc cgggttcaca 29161 ccattctcct gcctcagccc gacaagtagc tgggactaca ggcgtgtgcc accatgcacg 29221 gctaattttt tgtattttta gtagagatgg ggtttcaccg tgttagccag gatggtctcg 29281 atctcctgac ctcgtgatct gcctgcctag gcctcccaaa gtgctgggat tacaggcgtg 29341 agccactgca cctggcctta agtgttttta atacgtcatt gccttaagct aacaattctt 29401 aacctttgtt ctactgaagc cacgtggttg agataggctc tgagtctagc ttttaacctc 29461 tatctttttg tcttagaaat ctaagcagaa tgcaaatgac taagaataat gttgttgaaa 29521 taacataaaa taggttataa ctttgatact cattagtaac aaatctttca atacatctta 29581 cggtctgtta ggtgtagatt agtaatgaag tgggaagcca ctgcaagcta gtatacatgt 29641 agggaaagat agaaagcatt gaagccagaa gagagacaga ggacatttgg gctagatctg 29701 acaagaaaaa caaatgtttt agtattaatt tttgacttta aatttttttt ttatttagtg 29761 aatactggtg tttaatggtc tcattttaat aagtatgaca caggtagttt aaggtcatat 29821 attttatttg atgaaaataa ggtataggcc gggcacggtg gctcacacct gtaatcccag 29881 cactttggga ggccgaggca ggcggatcac ctgaggtcgg gagttagaga ctagcctcaa 29941 catggagaaa ccccgtctct actaaaaaaa atacaaaatt aggcgggcgt ggtggtgcat 30001 gcctgtaatc ccagctactc aggaggctga ggcaggagaa ttgcttgaac ctgggaggtg 30061 gaggttgcgg tgagccgaga tcacctcatt gcactccagc ctgggcaata agagcaaaac 30121 tccatctcaa aaaaaaaaaa ataaggtata agcgggctca ggaacatcat tggacatact 30181 gaaagaagaa aaatcagctg ggcgcagtgg ctcacgccgg taatcccaac actttgggag 30241 gccaaggcgg gtgaatcacc tgaagtcggg agttccagat cagcctgacc aacatggaga 30301 aaccctgtct ctactaaaaa tacaaaacta gccgggcatg gtggcgcatg cctgtaatcc 30361 cagctacttg ggaggctgag gcaggagagt tgcttgaact gagaaggcgg aggttgcggt 30421 gagccaagat tgcaccattg cactccagcc tgggcaacaa gagcgaaact ccgtctcaaa 30481 aaaaaaagga agaaaaatat ttttttaaat taattagttt atttattttt taagatggag 30541 ttttgccctg tcgcccaggc tggggtgcaa tggtgcaatc tcggctcact gcaacctccg 30601 cctcctgggt tcaagtgatt ctcctgcctc agcttcccga gtagctgtga ttacagccat 30661 atgccaccac gcccagccag ttttgtgttt tgttttgttt tttgtttttt ttttttgaga 30721 gggtgtcttg ctctgtcccc caagctggag tgcagcggcg cgatcttggc tcactgcaag 30781 ctctgcctcc caggttcaca ccattctctt gcctcagcct cccgagtagc tgggactaca 30841 ggtgcccgcc accacacccg gctaattttt ttgtgttttt agtagagatg gggtttcact 30901 gtgttagcca ggatggtctc gatctcctga ccttttgatc cacccgcctc agcctcccca 30961 agtgctggga ttataggcgt gagccactgt gcccggccta gtcttgtatt tttagtagag 31021 tcggggtttc tccatgttgg tcaggctgtt ctccaaatcc gacctcaggt gatccgcccg 31081 ccttggcctc caaaagtgca aggcattaca ggcatgagcc actgtgaccg gcaatgtttt 31141 taaatttttt aaatttaaat tttatttttt agagaccagg tctcactcta ttgctcaggc 31201 tggagtgcaa gggcacattc acagctcact gcagccttga cctccagggc tcaagcagtc 31261 ctctcacctc agtttcccga gtagctggga ctacagtgat aatgccactg cacctggcta 31321 atttttattt ttatttattt attttttttt gagacagagt cttgctctgt cacccaggct 31381 ggagtgcagt ggtgtaaatc tcagctcact gcagcctccg cctcctgggt tcaagtgatt 31441 ctcctgcctc agcctcccaa gtagctggga ttagaggtcc ccaccaccat gcctggctaa 31501 ttttttgtac tttcagtaga aatggggttt tgccatgttg gccaggctgt tctcgaactc 31561 ctgagctcag gtgatccaac tgtctcggcc tcccaaagtg ctgggattac aggcgtgagc 31621 cactgtgcct agcctgagcc accacgccgg cctaattttt aaattttttg tagagacagg 31681 gtctcattat gttgcccagg gtggtgtcaa gctccaggtc tcaagtgatc cccctacctc 31741 cgcctcccaa agttgtggga ttgtaggcat gagccactgc aagaaaacct taactgcagc 31801 ctaataattg ttttctttgg gataactttt aaagtacatt aaaagactat caacttaatt 31861 tctgatcata ttttgttgaa taaaataagt aaaatgtctt gtgaaacaaa atgcttttta 31921 acatccatat aaagctatct atatatagct atctatgtct atatagctat tttttttaac 31981 ttcctttatt ttccttacag ggtttcagac aaaatcaaaa agaaggaagg tgctcacatt 32041 ccttaaatta aggagtaagt ctgccagcat tatgaaagtg aatcttactt ttgtaaaact 32101 ttatggtttg tggaaaacaa atgtttttga acatttaaaa agttcagatg ttaaaaagtt 32161 gaaaggttaa tgtaaaacaa tcaatattaa agaattttga tgccaaaact attagataaa 32221 aggttaatct acatccctac tagaattctc atacttaact ggttggttat gtggaagaaa 32281 catactttca caataaagag ctttaggata tgatgccatt ttatatcact agtaggcaga 32341 ccagcagact tttttttatt gtgatatggg ataacctagg catactgcac tgtacactct 32401 gacatatgaa gtgctctagt caagtttaac tggtgtccac agaggacatg gtttaactgg 32461 aattcgtcaa gcctctggtt ctaatttctc atttgcagga aatgctggca tagagcagca 32521 ctaaatgaca ccactaaaga aacgatcaga cagatctgga atgtgaagcg ttatagaaga 32581 taactggcct catttcttca aaatatcaag tgttgggaaa gaaaaaagga agtggaatgg 32641 gtaactcttc ttgattaaaa gttatgtaat aaccaaatgc aatgtgaaat attttactgg 32701 actctatttt gaaaaaccat ctgtaaaaga ctggggtggg ggtgggaggc cagcacggtg 32761 gtgaggcagt tgagaaaatt tgaatgtgga ttagattttg aatgatattg gataattatt 32821 ggtaatttta tgagctgtga gaagggtgtt gtagtttata aaagactgtc ttaatttgca 32881 tacttaagca tttaggaatg aagtgttaga gtgtcttaaa atgtttcaaa tggtttaaca 32941 aaatgtatgt gaggcgtatg tggcaaaatg ttacagaatc taactggtgg acatggctgt 33001 tcattgtact gtttttttct atcttctata tgtttaaaag tatataataa aaatatttaa 33061 ttttttttta aattagctgt atctgtgatt gtatttcttt tttgcatatt attttgccct 33121 ttggcccata ttttgatatg gatgccacca tagcattttg tgtatgtgca tgtgtattcc 33181 cacttaatgt cacatttttc atgtctttac atattcttat ttttgtttgt ttttgagaca 33241 gagtctcgct ctgctgccca cgctggagtg cagtggtgca atctcagctc actgcaacct 33301 gtgctatccg ggttcaagcg gttctcgtgc ctcagccacg tgagtagttg ggattacagg 33361 catgtggcac catgccccac taagttttgt atttttagta gagatggagt ttcaccatgt 33421 tggccaggct ggtctcaaac tcctgccctc aagtgattcg accaccctgg cctcccaaag 33481 tgctgggatt acagccgtga gccaccgcac acggcctctc tatttatttc tatacatagc 33541 ttttcacatt atattatgtt tatatattgt ttatatctgt atttcctctt tcattagaga 33601 aaaggtagta catcttattc ttcatggtgt ctacaatatc tggcagtttt tggaagtcaa 33661 gcgtgagctt agagcataga ctggtgggat tgtcaaagaa gagggcaact ggaagagaac 33721 tgtcagttat ttttggatca gtctttaatt catcatgacg ggttaggcat tagttgtatt 33781 tcttgctaat tttgaagaag acttattaac aaatcctaca ttaggtaaat ggttttgaaa 33841 gttgagttaa tcataatggt gtttgaccta ggactatttt taggccctat ttatcttaat 33901 atcgaataat gaagcagctt cccccttaga tatagacaga aaacatcaaa gccaccacac 33961 tacctggctg gatttatcct agtaataaaa tcaaaactga gctagttctc tggctttcat 34021 tgtaataatt gtccttgtgg ttgtaaggaa tctagatgaa aattacatgg tctgttctac 34081 agccacagct gtacctacat tcagaagaca gacaaaagtt gctgtgtttg aagagatcct 34141 tcattaaggg atcagacaga gattactttg agacatattc taagtttaac ttttctgcag 34201 ggttgccatt aacagaaata aactacagag ttaatttctt tttgtttttg atacagtcta 34261 actctcaccc aagctggagt gcagtggcgc aatttcagct cactgcaacc tctgcctccc 34321 aggttcaagc aattctcctg cctcagcctc ccgagcagct gggactacag gcatgtgcca 34381 ctatgcctgg ctaatttttg tatttttagt agtagagacg tggtttcgcc acgttggcca 34441 ggctggtctg gaactcctga ccccaggtaa tccacctgcc tcggcctccc aaagtgctgg 34501 gattacaagc ttgagccact acgcctgacc cagagttaac tttttaaaaa agtttttatg 34561 aacttaagtc ttgtgatgtt tgaaataatg gattcaattt agacatcaaa ttccagaagt 34621 tactaagagc agctgggcgc ggcagctcac acctgtaatc ccagcacttt gggaggccga 34681 ggcgggtgga tcacctgaga tcaggagttc cagaccagcc tggccaacat agtaaaaccc 34741 tgtctctact aaaaatacaa aaattagccc ggcatggtgg cacgcgcctg tagtcccagc 34801 tacttgggag gctgaggcag gagaattgct tgaacccggg aggtggaggt tgtggtgagc 34861 cgagattgtg ccactgtact caagcctggg ctaaaaagcg agactccgtc tcaaaaaaaa 34921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aacaaaacac gttactaaga 34981 gcaactctgg gccaggcacg gtggcttaca cctgtaatcc cagcattttg ggaggacgag 35041 acaggcggat cacttgagcc caggagttca ag //