LOCUS       NG_008239              12976 bp    DNA     linear   PRI 29-DEC-2010
DEFINITION  Homo sapiens poly(A) binding protein, nuclear 1 (PABPN1),
            RefSeqGene on chromosome 14.
ACCESSION   NG_008239
VERSION     NG_008239.1  GI:194294503
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12976)
  AUTHORS   Calado,A., Kutay,U., Kuhn,U., Wahle,E. and Carmo-Fonseca,M.
  TITLE     Deciphering the cellular pathway for transport of poly(A)-binding
            protein II
  JOURNAL   RNA 6 (2), 245-256 (2000)
   PUBMED   10688363
REFERENCE   2  (bases 1 to 12976)
  AUTHORS   Brais,B., Bouchard,J.P., Xie,Y.G., Rochefort,D.L., Chretien,N.,
            Tome,F.M., Lafreniere,R.G., Rommens,J.M., Uyama,E., Nohira,O.,
            Blumen,S., Korczyn,A.D., Heutink,P., Mathieu,J., Duranceau,A.,
            Codere,F., Fardeau,M. and Rouleau,G.A.
  TITLE     Short GCG expansions in the PABP2 gene cause oculopharyngeal
            muscular dystrophy
  JOURNAL   Nat. Genet. 18 (2), 164-167 (1998)
   PUBMED   9462747
  REMARK    Erratum:[Nat Genet 1998 Aug;19(4):404. Korcyn AD [corrected to
            Korczyn AD]]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049829.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes an abundant nuclear protein that binds
            with high affinity to nascent poly(A) tails. The protein is
            required for progressive and efficient polymerization of poly(A)
            tails at the 3' ends of eukaryotic transcripts and controls the
            size of the poly(A) tail to about 250 nt. At steady-state, this
            protein is localized in the nucleus whereas a different poly(A)
            binding protein is localized in the cytoplasm. This gene contains a
            GCG trinucleotide repeat at the 5' end of the coding region, and
            expansion of this repeat from the normal 6 copies to 8-13 copies
            leads to autosomal dominant oculopharyngeal muscular dystrophy
            (OPMD) disease. Related pseudogenes have been identified on
            chromosomes 19 and X. Read-through transcription also exists
            between this gene and the neighboring upstream BCL2-like 2 (BCL2L2)
            gene. [provided by RefSeq].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12976             AL049829.4         97246-110221
FEATURES             Location/Qualifiers
     source          1..12976
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2-q13"
     gene            5001..10998
                     /gene="PABPN1"
                     /gene_synonym="OPMD; PAB2; PABII; PABP-2; PABP2"
                     /note="poly(A) binding protein, nuclear 1"
                     /db_xref="GeneID:8106"
                     /db_xref="HGNC:8565"
                     /db_xref="MIM:602279"
     mRNA            join(5001..6633,6994..7108,7812..7879,8190..8296,
                     8778..8865,8951..9102,10060..10998)
                     /gene="PABPN1"
                     /gene_synonym="OPMD; PAB2; PABII; PABP-2; PABP2"
                     /product="poly(A) binding protein, nuclear 1"
                     /transcript_id="NM_004643.3"
                     /db_xref="GI:315434252"
                     /db_xref="GeneID:8106"
                     /db_xref="HGNC:8565"
                     /db_xref="MIM:602279"
     exon            5001..6633
                     /gene="PABPN1"
                     /gene_synonym="OPMD; PAB2; PABII; PABP-2; PABP2"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(6283..6633,6994..7108,7812..7879,8190..8296,
                     8778..8865,8951..9102,10060..10099)
                     /gene="PABPN1"
                     /gene_synonym="OPMD; PAB2; PABII; PABP-2; PABP2"
                     /note="poly(A) binding protein 2; poly(A) binding protein
                     II; polyadenylate-binding protein 2"
                     /codon_start=1
                     /product="polyadenylate-binding protein 2"
                     /protein_id="NP_004634.1"
                     /db_xref="GI:4758876"
                     /db_xref="CCDS:CCDS9592.1"
                     /db_xref="GeneID:8106"
                     /db_xref="HGNC:8565"
                     /db_xref="MIM:602279"
     gene            6994..10998
                     /gene="BCL2L2-PABPN1"
                     /note="BCL2L2-PABPN1 read-through transcript"
                     /db_xref="GeneID:100529063"
     mRNA            join(6994..7108,7812..7879,8190..8296,8778..8865,
                     8951..9102,10060..10998)
                     /gene="BCL2L2-PABPN1"
                     /product="BCL2L2-PABPN1 read-through transcript"
                     /transcript_id="NM_001199864.1"
                     /db_xref="GI:315434254"
                     /db_xref="GeneID:100529063"
     CDS             join(<6994..7108,7812..7879,8190..8296,8778..8865,
                     8951..9102,10060..10099)
                     /gene="BCL2L2-PABPN1"
                     /exception="unclassified translation discrepancy"
                     /codon_start=1
                     /product="BCL2L2-PABPN1 protein"
                     /protein_id="NP_001186793.1"
                     /db_xref="GI:315434255"
                     /db_xref="GeneID:100529063"
     exon            6994..7108
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            7812..7879
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     exon            8190..8296
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     exon            8778..8865
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     exon            8951..9102
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     STS             9909..10062
                     /gene="BCL2L2-PABPN1"
                     /standard_name="PABPN"
                     /db_xref="UniSTS:266224"
     exon            10060..10998
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:1.39.8"
                     /number=7
     STS             10258..10727
                     /gene="BCL2L2-PABPN1"
                     /standard_name="MARC_26170-26171:1030649367:1"
                     /db_xref="UniSTS:268968"
     STS             10513..10706
                     /gene="BCL2L2-PABPN1"
                     /standard_name="RH65111"
                     /db_xref="UniSTS:92478"
ORIGIN      
        1 gagggtcctt cacatttaaa tggctacccc acttccatgc aaaggcaaac ttagggagcc
       61 aaggtaagca ggaccagacc acattagaag attattgagg tctgctccaa gacagaggtc
      121 agtaaaggag aaagactcca tggttctaca tcagcactgt ccaatagaaa tataatgcaa
      181 gccacatgta gttttacatt ttctagtaac ctcatttaaa atgcaaaaag aaattattaa
      241 accaatttta atattttatt tagcccagta tataaaaata ttatcatttc aacatggaat
      301 taatattaaa cagttattaa tgaattatgt cacattctgt ttttcatact aagtcttcaa
      361 aattcagtgt gtattcaaca cttagcacat ctcaagttgg actactcatg tttcaagtgg
      421 tcagtagcca tgtgtgacta gtggctatca tattaaagtg tagctctaga tcataggtca
      481 ttattatagt ctgtaaaaat ttcaaagtag ttccagatca tagagcatta ttgtagtctg
      541 taaaaatttc aagaaaggag ataaaaatag ggatgaaact accaagacgt caaatattta
      601 tgtcgtttgg ggagaaaact tttctgggaa gaactatgaa tgccctcacc catttttact
      661 acttaattct ccttttctta actccactga gccattccct tcttcttctt cttttttttt
      721 tttttttttg agatcgccca ggctggagtg cagtggcgcg atctcggctc actgcaacct
      781 ctgcatcccg ggttcaattg attctcctgc ctcagcctcc cgagtagctg ggactacagg
      841 cgcaggtcac cacgcccagc taatttttgt atttttagtt gagacggggt ttcaccatgt
      901 tggccaggat ggtcttgatc tcctgacctc gtgatccacc cacctcggtc tcccaaagtg
      961 ctggaattac aggcgtgagc cactgcgccc ggccgattcc cttttattaa tacattttcc
     1021 cgtcttctgg ggcacagtat cattggagtt tcactttttc caaaactcca tggtcctttg
     1081 tttataggtt attacttaga gagaattata atgggtgaat ctcacaccat tacataccaa
     1141 atttcaaaaa attcattctc agaggaaaac ttatctcttt gatattctct atgcatcaac
     1201 aacaggcagg ataataaata cgagtattca ttcatttatt tttttacttt tttaaaaaaa
     1261 taagattatt cattactgaa gatgactcat tcagttatca tttactgagc acagagtgat
     1321 aggcaaaggg aacacaaata taagatggtt ccctgtcttt tacagtttat agactaatag
     1381 ggaaggatct tacaagtcac cattcaaaaa gctttttttt ttttttgaga cagtctcact
     1441 ctgctgccca gactggagtg cagtggcacg atctcggctc actgcaacct ccgcctcacg
     1501 ggttcaagtc attctcgtgc ctcagcctgc tgagtagctg ggattacagg cgcacgccac
     1561 catgcccagc taatttttgt atttttagta gagacggggt ttcgccatgt tggccaggct
     1621 ggtctcgaac tcctgacctc aggtgattta ccctcctcgg cctcccaaag tgctgggatt
     1681 acaggcatga gtcatcgcac ctgtccctca aatagccttt taaatatgtt tgcttttttc
     1741 tttttttgag acagggtcct actctgttgc tgaggctgga gtattgtggc atgatcatag
     1801 ctcactgcag cctggaaccc ctgggttcaa gtgatccttc tgtctcagcg tctggattag
     1861 ctgggactat gccaccacac tcagctaatg tgtttgtttc tttcataagg taattatgcc
     1921 tagtagaaga agtttgaaag ttggagtgat tttttaaaaa taaatatgta atgggctgga
     1981 catggtgtct catgcctgta atcccaacac tttgggaggc tgagttgggc agatggcttg
     2041 agccccagga gtttgagaca agcctaagca acatagtgag accttgtctc cacaaaaata
     2101 gaaaaaatta gctgggcata gtggtgcaca cctgtagtcc cagccacttc ggaagctgag
     2161 gagggaggat tgcttgagcc aggagtttga gggtgtggtc ggctgtgatc atgccactgt
     2221 attccagcct gggcgacaac gaccctgtct caaacaacaa aggcagcaaa ataaacaagt
     2281 aaataaataa ataatgattg tggaaaattt gtagaacata gaaaattata aagaaaatga
     2341 atcataatgc tgtcacccag agacaattac tattttggta tacttctttc tagtatttgt
     2401 ttgtctgctt ttatgatcat gcaattttgt atacgcaatt ctgcttacca ttatattgca
     2461 agcatttttt cttgatgtta aaatgtttca aagtcataat gactatatac aattacttct
     2521 acttgtgtac agtaatttta atgcccactt ggtcctttat ctgtattttt tcactttgat
     2581 aaaaatactt attctggctg ggcattgtgg ctcacgcctg taattccagc actttgggag
     2641 gctgaggcgg gctgatcacc tgagttcagg agttcgagac caccgtgggc aatatggtaa
     2701 aaccccatct ctactaaaat acaaaaaatt agctgggctt ggtggtggtg cgcctgtagt
     2761 accagatact taggaggctg aggcacaaga atcgcttgag ccctggaggt ggaggttgca
     2821 gtgagctgag attacgccac tgcactccag cttggttggg ctatggagtg agactctgtc
     2881 tcaaaaaaaa caaaacaaaa acaaacaaac aaaaaatatt tattcacaaa ttggattaca
     2941 tttttagaag agataagaaa taggattact gggttaagaa tctcaacttt tttttttttt
     3001 ttttggagag agtctccctc tgtcacccag gctggaatat agtgtcgcga tcttggctca
     3061 ctgcaacctc cacctcccag gttcaagcct ttctcctgcc tcagcctcct gactagctgg
     3121 gattacaggc gcccaccacc acacccagtt aatttttgta cttttagtag agacagggtt
     3181 tcaccatttt ggccaggctg gtctcgaact cctgacctta ggtgatccac ctgccttggc
     3241 ctcccaaagt gctgggatta caggccgtga gccacctcac ctggctcttt tttttttttt
     3301 ttttttgaga cagggtctca ctctgttgcc agtctgaagt gcacgtagca ccaattatgg
     3361 ttcactgtag cctcagcctc ccaagtagct gggcagggac tacaggcaca cgccactttg
     3421 cccagctaat ttttgtattt ttagtggaga atgggttttg ccatattgcc caggctggtt
     3481 ttgaactcct ggactcaagc aatctggctc ccaaagtgtt gtgagccact ccgcctggcc
     3541 ttaagaatct caccatttta aaagcttttg atatatactg ccaaagaata gaaagattgt
     3601 actggttctt gctccttttt tcctcccatg cctaagtttt taaaaaaaat cagatatagt
     3661 tgtaattata tattatgtac aattttacat tcttctttgg cttaacaaaa ttattttcgc
     3721 atgtttgtca tactatgtaa cccttttaag agatgcataa taattttttt tggatataat
     3781 tatagtttgc ttaaactttt gtttattgtt ggaatttagt cttgccattt ttcacacata
     3841 atttttatgt attaaagcag gccttatagt agtagtgatc tgagctttga aagctggctt
     3901 tgaattccct gcacattatt atatatatta cataatatat attatgtata atatatatat
     3961 aatttttatt ttttcctttg agacagagtc ttgctgttgc ccaggcgatt ctcctgcctc
     4021 agcctcccga gcagctgggt ttacaggcat gtaccaccat gcccagctaa tttttgtatt
     4081 tttagtagag atggggtttc gccatgttgg ccaggctggt ctgaaactcc tgggctcagg
     4141 tgatcctccc gccacagcct cccaaagagc tgggataaca ggtgtgagcc accacgccca
     4201 gccagccctg cacacttcta attagtccaa tgacttaggc aagtttcttc atttcattaa
     4261 gcctttttct ttttccctaa aaaaggttat ggttttggaa atactttccc cgtggggttg
     4321 ttgtgagagt ccagtgaaat aataaggagt ggtgcttatt acaaaatcaa acgctcaaca
     4381 aaaataggat tcaaagccat ttttaaaaat cacatttcct tttgttggct tgattaaatt
     4441 gggtaccaat aagattaaca aatcttgatt aggttaagat tagtataaaa gacctttctt
     4501 ccagggtatt caatcattta gagcttgtct tcggtgctca actttagtta tcccagatca
     4561 ctgaagctga gatggctgat gaagtaattt gcagtgaaat tttaagcgac tgtgactctg
     4621 ctgcaagttc cccagatctt gaggtaagga attgtgagaa aaagtggggg tgaggggaat
     4681 agtggggtat aatgagtcac ttgatttttt ggtttgctaa tgaggatctt ctcttgtcca
     4741 aatccctcgg ccaaccatgt ttgtttaact ttttggttgg gctatatgta tctttcgaac
     4801 tgtaggttag tgtgcccaca aaaatttctc ttgcaaacgt acactgccat tcctttcttt
     4861 ttaataaatg tgtaggactg ctaccaaaat atggcagtcc tgccttccag ggctaggtct
     4921 cattggtact tggggtgcag gggtgtagtg ggaacctgcc aggagaaatt cctctgggat
     4981 cttgggggct tgagggctta aatgaagggt ggcacccaaa tccccaatca atgcctgttc
     5041 aatcaacaaa catctaacag gacattatgt ggtaggcata ttgccaggcc gtggagatgc
     5101 gaatataaat aggaaccggc ccctcatctg caggcgctca caacctagtt aggaaacagt
     5161 aaaacaatta agcgcgccgt ggagataggc ccacttgtcc tgggaaatga ggggaagctg
     5221 gggtttgcag tggtttgatt gaagggggac tacatgttag aggcacagac tgggtgcagg
     5281 tacacccaaa ggaacgagaa gagtggaagg aaacaacatc cacaaagtaa ccacatgctg
     5341 gcgtatcgaa ggccgtgatt tacggttttg agactttacc tcgccagcaa aggggggcca
     5401 gtctgttagc ggtgcagatt ggaggggtga cattggaagc tgtccaggaa aaagaaaatg
     5461 gaactgggga gcagaaggcc tacgcaagag ggcgggacag acaggacttg tgactagtag
     5521 ctctggactg aggaatcctc cctgctttct ggtgcgggag agctagtgga tgatggtgcc
     5581 aataacctgg atggggaaag taagctccct cctggaatgc ttcattcaca acctccattt
     5641 tcagcaacat cccatctact ggtgcttcct ggtcgagata caagtttcct gaaactgctg
     5701 ctctgttttg ggcctcaccc ggccaacagc tcactagctg gcaagcagta gtatcaagat
     5761 ggcggccccc taggactggc tagtcatgtg acctcgggtt tcccaagttt gaagcccggc
     5821 agtcctttcg ggggcaaggt tcacctgtca cgaaacgagt gtcacccctt cgactctcgc
     5881 aagccaatcg gcatctgaga ctgggccact gcggtgaggc gatcggaaga ttggtccttt
     5941 ccagtcgcct agctagggcc aatcacggag cgtcccatac ttcgcgggcc cgcccgtagg
     6001 ccggggagaa gcaggaatat cgtcacagcg tggcggtatt attacctaag gactcgatag
     6061 gaggtgggac gcgtgttgat tgacaggcag atttccccta ccgggatttg agaatttggc
     6121 gcagtgcccc gccttagagg tggggcctta tttgattgcc aagtaatatt ccccaatgga
     6181 gtactagctc atggtgacgg gcaggcagct tgactaatga gtcctcggcg tggccggcgc
     6241 agctctccaa tcgccgggcg gcgggcccca gtctgagcgg cgatggcggc ggcggcggcg
     6301 gcggcagcag cagcgggggc tgcgggcggt cggggctccg ggccggggcg gcggcgccat
     6361 cttgtgcccg gggccggtgg ggaggccggg gagggggccc cggggggcgc aggggactac
     6421 gggaacggcc tggagtctga ggaactggag cctgaggagc tgctgctgga gcccgagccg
     6481 gagcccgagc ccgaagagga gccgccccgg ccccgcgccc ccccgggagc tccgggccct
     6541 gggcctggtt cgggagcccc cggcagccaa gaggaggagg aggagccggg actggtcgag
     6601 ggtgacccgg gggacggcgc cattgaggac ccggtgaggg aaggagggcg agcgagcagg
     6661 ccggcggctg gccggccggg tcactggagg cccagagctc gggcgagcgg gtggcaggcg
     6721 gggggtgggg ttgggcgggg aataacgtgg ctggggccgg gtcgggccgg ggatgggtca
     6781 gcgatcacta caaggggccc gactggcttg attcgggcgt cacggttgcc tagtgttgtt
     6841 ctagagaggg tagcttttct tttatcacga ccctcgcatg gggcgaggga aatggccgag
     6901 catggctgag gccgcgctct ggccgagagc agggcacagc ccctgcgttg gttcctctta
     6961 agctgtcctc cataccctcc ccacttatat taggagctgg aagctatcaa agctcgagtc
     7021 agggagatgg aggaagaagc tgagaagcta aaggagctac agaacgaggt agagaagcag
     7081 atgaatatga gtccacctcc aggcaatggt gagtaactgg cggttgcacg cggagcccgg
     7141 gttctcgggt tggaagggtt gtggggagga tggggaatgt ggggttagat actcggcacc
     7201 ctggagctgc ttgtctgagc tattatgact gtgccgcggt catagtccgt tgtgtgttcc
     7261 tctgaccttt gtgaggcaga acgtatattt tggtggtggt agccttgtgc ctccctttgt
     7321 gcctgttata attgtgttgc tctttgttct tagtctacgt ctatctttct ttgtagaggt
     7381 tgcgtgctcg catttgacct tcaaatctaa tagtttttcc tccaattgga gacgctttag
     7441 gattctaaga gaaagcaagc tgcaaggggt ttccccttta atctagaaat gtggagtctc
     7501 agcccactta attttgctca ctcttaaaag catttcaacc aaagccattc attagggatt
     7561 tgatttggag gcaggaggga ttcctatact gttttaagtg tgtattaatt ctttcaattt
     7621 attgaatatt tagtgagtac ctgctatgca ctaggcacta ttctcggttg tgggtacagc
     7681 agggaacagc acagaccaaa atctttgcct tcactgagct tatgggatag tgctggtggt
     7741 ggaagtgcaa catattggtc aagtagaaaa caagtgtgtg gtttttgtaa aaaattattt
     7801 tttcctgata gctggcccgg tgatcatgtc cattgaggag aagatggagg ctgatgcccg
     7861 ttccatctat gttggcaatg tacgtactgg ggctctgact ggggttgggg gcaagttctt
     7921 cttttgggga attatttaat agtcctgaaa ggaacatctc cgggatagat gtggttttgg
     7981 gtgtggaggg agtgtgggaa ggaggttaaa ggtaatggaa tgatcagtaa tcagcaaagg
     8041 ctctgggttt ggaaggaaaa gagattaatt cctcaaatta ccagatttca tgtgctttgg
     8101 tgtatgatgg cccagaccaa aggctcggga gggttccttt tgagacagga atttgcctgg
     8161 tgcctgtgaa atttttctcc tctcatcagg tggactatgg tgcaacagca gaagagctgg
     8221 aagctcactt tcatggctgt ggttcagtca accgtgttac catactgtgt gacaaattta
     8281 gtggccatcc caaagggtaa gtaaagggga gtaagttgag ataatttaaa ttacagtgta
     8341 caaatagata aattatgttt tatattgagc agtaagttat ttggtgttaa cacaggtgat
     8401 ctgtgtcatt taagatcatg gcattaatgt tgatatatca ggagttgcac ctaaatgtct
     8461 tcagaggcca gataacaaaa atgaaggcta gatgtgggtg ggattacgaa ctagaagggg
     8521 aggggcagct tctacttggc ctattatggc catatggaaa ttcaggccct gtgtgtctta
     8581 tttttacaaa tttcaaagag tagctggaaa ttttaaaatt taaatgattt cgaatgattg
     8641 aaattttcca tttagaagaa ttttgacaaa taaaaaatat aactgcattg tagcccaaaa
     8701 cgaagcatgc ctgcaggttg aatttgacct gtgaggtatt tgtaacctca gagagataca
     8761 atgacaattc ttttcaggtt tgcgtatata gagttctcag acaaagagtc agtgaggact
     8821 tccttggcct tagatgagtc cctatttaga ggaaggcaaa tcaaggtaag cctatgtcca
     8881 ttgctgttct agttgtgtat aaactctcca ggttgccttt aaggctatca tttgttcatc
     8941 tctgactcag gtgatcccaa aacgaaccaa cagaccaggc atcagcacaa cagaccgggg
     9001 ttttccacga gcccgctacc gcgcccggac caccaactac aacagctccc gctctcgatt
     9061 ctacagtggt tttaacagca ggccccgggg tcgcgtctac aggtcaggat agatgggctg
     9121 ctcctctttc ccccgcctcc cgtgagcccc gtatgcttcc tcctctctgg tctgaggaac
     9181 ctccctcccc ccacccctcc ccgtggtctt caggaacttt gtctcctgcc tgtgcaggtt
     9241 gaggaaggta gttgcaggcc aggccagaag gccagcctca tcatcttttc tgcagtagaa
     9301 attggtgata agggctgcat ccctcccttg gttcaaagag gcttccaccc ccagcctttt
     9361 ttttcttggg agttggtggc atttgaaggt gtttgcggac aaaactggga ggaacagggc
     9421 ctccaggcag tgaaagcact gcttggacat ttgttacttt tttcggagtt agggagggat
     9481 tgaagactga acctcccttg gaagaatacc agaggctagc tagttgatcc tccccaacag
     9541 ccttgtggga ggattttgag atacttattc tttatttgag ccagtcttgc aaggttaact
     9601 tctcactggg cctagtgtgg tgcccaggtt tttgccttgc ttcacttctg tctctacatt
     9661 taaatagacg ggttaggcat ataaaccttg gcttttcata agctctacct gcctatcccc
     9721 aggagttagg gaggatctat ttgtgatggc ctagggttta agagctgtgg aggactgaaa
     9781 actggataaa aagggggtcc ttttccttgc ccctgtctct cactcagatg cgcttctttt
     9841 tcgccactgt ttggcagttt tctgttaagc ccccctcccc ctgccccagt tctccaggtg
     9901 cgttactatt tctgggatca tggggtcagt tttaggacac ttgaacactt cttttccccc
     9961 cttcccttca cagtaactgg ggcaggggcc tacggggagg ggcttgtact gaactatcta
    10021 gtgatcacgt taacacctaa ctctccttct ttcttccagg ggccgggcta gagcgacatc
    10081 atggtattcc ccttactaaa aaaagtgtgt attaggagga gagagaggaa aaaaagagga
    10141 aagaaggaaa aaaaaaagaa ttaaaaaaaa aaaaaagaaa aacagaagat gaccttgatg
    10201 gaaaaaaaat attttttaaa aaaaagatat actgtggaag gggggagaat cccataacta
    10261 actgctgagg agggacctgc tttggggagt aggggaaggc ccagggagtg gggcaggggg
    10321 ctgcttattc actctgggga ttcgccatgg acacgtctca actgcgcaag ctgctgccca
    10381 tgtttccctg ccccacttca cccccttggg ggctgctcaa gggtaggtgg gcgtgggtgg
    10441 taggaggttt ttttttttac ccagggctct ggaaggacac caaactgttc tgcttgttac
    10501 cttccctccg tcttctcctc gcctttcaca gtcccctcct gcctgctcct gtccagccag
    10561 gtctaccacc caccccaccc ctcttctccg gctccctgcc cctccagatt gcctggtgat
    10621 ctattttgtt tccttttgtg tttctttttc tgttttgagt gtctttcttt gcaggtttct
    10681 gtagccggaa gatctccgtt ccgctcccag cggctccagt gtaaattccc cttccccctg
    10741 gggaaatgca ctaccttgtt ttggggggtt taggggtgtt tttgtttttc agttgttttg
    10801 tttttttgtt tttttttttt ttcctttgcc ttttttccct tttatttgga gggaatggga
    10861 ggaagtggga acagggaggt gggaggtgga ttttgtttat ttttttagct catttccagg
    10921 ggtgggaatt tttttttaat atgtgtcatg aataaagttg tttttgaaaa taaaaattgt
    10981 ttggcctttt gggtgtaagg attatttatc ttcctattct ctcttagatc gcagatggct
    11041 attaattctg ccttgtggta gaagtactgg tgttgtggaa gggaggttgc cacttgtgaa
    11101 ttaaggagta ggaattacat tacaactagc aggaacatta tgtgtttagt tgagaatgat
    11161 aggttttctg gataacatgt aaccctgatt ggcatttgag agagaaataa gcctgggaaa
    11221 gtaaaagaat agctgaattg ggccgggcat ggtggctcac tgctacaatc ccaggacttt
    11281 gggaggctga ggtgggcaga tcacgaggtc aggagatcaa gaccatcttg gctaacatgg
    11341 cgaaacccca cctctactaa aaatacagaa aattagcctg acgaggtggc gggtgcctgt
    11401 ggtcccagct actcgggagg ctgagccagg agaatggcgt gaacccagga ggtggagctt
    11461 gcagtgagcc aagttcacac cactgcactc cagcctgggt gacagagtga aactgtctca
    11521 aaataaaaaa aggaatagcc gaattactga cctaatggcg cttttgtgtg ctcctgatac
    11581 agcttacgtg caaatgaact atccatgcct gcagccctag agctttggat tggggtctgg
    11641 gtaaccttgt ctttggggtc tcgctatgtt gaccaagcaa tcttcccatc ttagcctccc
    11701 aaagtattgg gattacaagt gtgaaccact gcacccagct accttttcta cctcaaggtg
    11761 ggcccaagaa atgcagaaga caaaatacac ttagctaaga gacaatcgga aagcttgttt
    11821 ttccaaccat gcagtaacca tttaatgtgt ccagctaact tatattaatt ggatcattta
    11881 tttttttgag atggtcttgc tttgtcaccc aggctggagt gcagtggctc actgcagcct
    11941 caacctcccg ggctcaagtg atcctcccac ctcagtgtcc tacatagctg tgactatagg
    12001 tgcctgcctt cacacttggc taattttttg tagagacagt tttgctgtgt tgcccaggct
    12061 gtcccaaact cctgagctca agcagtcctc ctggcttggc cttcctatag gcgtgagcca
    12121 cagctcctgg ccaggattag tttattagga cttcacaact ggctttcact gttttcatat
    12181 ctaaattttg tcttgggcat cctaatttct ccatttttta ttccagtgtc agattggtct
    12241 taaaacttga acactacatc actagccagg ttgaaccttc agacttcatt acctatagaa
    12301 tttcttagta tttcaacctt actatttttt catttacttc tcaggatgtt ttgttcacaa
    12361 ttgcctctga cctggatgct cttcaaaaat catatgttaa agaaatggct ctgtggccgg
    12421 gcgcagtggc tcacacctgc agtctcagca ctttgggagg cagaggtggg cggatcactt
    12481 gaggtcagga gtttgagacc agcctggcca acatggtgaa atcccgtctc tactaaaaat
    12541 acaaaaatta gccaggtgtg gtggcatgca cctgtagtcc cagctactct ggaggctaag
    12601 gcaggagaat cgtttgaaca taggaggtgg agattgaggt gagctgagac tcagccactg
    12661 cacttccagc ctgggtgaca gagcgagact ctgtctcaaa acaaacaaaa caaaaaactc
    12721 tgttatatct gaagccttaa cccacctctc aaattgcagt attttctaaa atctcatgtc
    12781 agtgttatcc accacatatt ttaggatttg gtcatttatt ctactttctg ttatgggtta
    12841 ggcatttgag gtctatcttt tctcctaact agattcacct aaaatagtgc cgtgatctct
    12901 gtggcttctg cagaggctga ttagtgaggg tctggatagt gttcaatata aactttttac
    12961 tggaagaatg aaacag
//

