LOCUS       NG_008376               8953 bp    DNA     linear   PRI 03-JUL-2014
DEFINITION  Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6
            (CYP2D6), RefSeqGene on chromosome 22.
ACCESSION   NG_008376
VERSION     NG_008376.3  GI:507834151
KEYWORDS    RefSeq; RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8953)
  AUTHORS   Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM and Nebert
            DW.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Sarah Sim, Johan den Dunnen. The reference
            sequence was derived from AY545216.1.
            This sequence is a reference standard in the RefSeqGene project.
            On May 30, 2013 this sequence version replaced gi:392583869.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum and is known to
            metabolize as many as 25% of commonly prescribed drugs. Its
            substrates include antidepressants, antipsychotics, analgesics and
            antitussives, beta adrenergic blocking agents, antiarrythmics and
            antiemetics. The gene is highly polymorphic in the human
            population; certain alleles result in the poor metabolizer
            phenotype, characterized by a decreased ability to metabolize the
            enzyme's substrates. Some individuals with the poor metabolizer
            phenotype have no functional protein since they carry 2 null
            alleles whereas in other individuals the gene is absent. This gene
            can vary in copy number and individuals with the ultrarapid
            metabolizer phenotype can have 3 or more active copies of the gene.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2014].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8953              AY545216.1         1-8953
FEATURES             Location/Qualifiers
     source          1..8953
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            4111..8493
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /note="cytochrome P450, family 2, subfamily D, polypeptide
                     6"
                     /db_xref="GeneID:1565"
                     /db_xref="HGNC:HGNC:2625"
                     /db_xref="MIM:124030"
     mRNA            join(4111..4380,5083..5254,5807..5959,6048..6208,
                     6642..6818,7009..7150,7358..7545,8000..8141,8240..8493)
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /product="cytochrome P450, family 2, subfamily D,
                     polypeptide 6, transcript variant 1"
                     /transcript_id="NM_000106.5"
                     /db_xref="GI:392513720"
                     /db_xref="GeneID:1565"
                     /db_xref="HGNC:HGNC:2625"
                     /db_xref="MIM:124030"
     exon            4111..4380
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(4201..4380,5083..5254,5807..5959,6048..6208,
                     6642..6818,7009..7150,7358..7545,8000..8141,8240..8418)
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /EC_number="1.14.14.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     debrisoquine 4-hydroxylase; microsomal monooxygenase;
                     xenobiotic monooxygenase; flavoprotein-linked
                     monooxygenase; cytochrome P450, subfamily IID
                     (debrisoquine, sparteine, etc., -metabolizing),
                     polypeptide 6; cytochrome P450, family 2, subfamily D,
                     polypeptide 7 pseudogene 2; cytochrome P450, family 2,
                     subfamily D, polypeptide 8 pseudogene 2; cytochrome P450,
                     subfamily II (debrisoquine, sparteine, etc.,
                     -metabolising), polypeptide 7 pseudogene 2; cytochrome
                     P450, subfamily IID (debrisoquine, sparteine, etc.,
                     -metabolising), polypeptide 8 pseudogene 2; cytochrome
                     P450, subfamily IID (debrisoquine, sparteine, etc.,
                     -metabolizing)-like 1; cytochrome P450 2D6; cytochrome
                     P450-DB1"
                     /codon_start=1
                     /product="cytochrome P450 2D6 isoform 1"
                     /protein_id="NP_000097.3"
                     /db_xref="GI:392513721"
                     /db_xref="CCDS:CCDS46721.1"
                     /db_xref="GeneID:1565"
                     /db_xref="HGNC:HGNC:2625"
                     /db_xref="MIM:124030"
                     /translation="MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLG
                     NLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRP
                     PVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACL
                     CAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESG
                     FLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFL
                     AEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQE
                     IDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKG
                     TTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLAR
                     MELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR"
     exon            5083..5254
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            5807..5959
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     exon            6048..6208
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     exon            6642..6818
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     exon            7009..7150
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     exon            7358..7545
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=7
     exon            8000..8141
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=8
     exon            8240..8493
                     /gene="CYP2D6"
                     /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2;
                     CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=9
ORIGIN      
        1 attacagcct tctgagtcac tgacactaca ggtgtgagcc accatgtcca gcttgtagtg
       61 gttttgaaca gctcttgccc cttcttggga atctaggtgc cctgcacgtg ggtaaggctg
      121 tctgcagctg tgcccatatt caggaaggcc ggcaaggccc tgagccctca cacgtgactg
      181 acctgaggtg ctgtgcagac agcaggtgac ggctaaggga aagttgagca ctgcctagcc
      241 gagcactgaa gccacgcccg gcacacagag agagacccac tcggcaaaga cttcgcttcc
      301 aggcacctaa ggaactctct gaccagtcat tagctgacca ctgccgtaac tgaagagcgg
      361 cttcagtggc cacagctcgc agggaatgga gacattaatg cttagtcaga attagttcag
      421 aaaagtcacc cagcaaagaa acagctccaa caggcaacaa caacaacaca tccttggcag
      481 ggaagagaat ctgacttccg gagttgccac attatcgccc gtgaaatgtc caggttttaa
      541 caaattatga gacatggaaa ggaaaccgaa aggacgaccc agacacggga aaagtcacca
      601 atgggaccag cccgatgctg caattgctag acaaagacgt tcagtcagct catttaaata
      661 tgttcaaaga cctaaaacat gctgcatctg aggctgcacc ggctggaacc tgctgatctc
      721 ggaagctaag catggtcagg cctggctagt acttcaaagg gagaaaccac gtgtaggcct
      781 ggtgcagtgg ctcacaccta taatcctagc actctgggaa gctgaggccc gtggattgct
      841 tgagcccagg agtttgagag cagcttggga aatgtggtga gacccccatc tctacaaaaa
      901 aatttaaaaa attagctggc tgcctatggt cccagcctct caggatgctg aggtaggagg
      961 atcacttcag cccaggaagt tgaggctgca gtgagccatg actgcatcac tgcactccag
     1021 cttgggcgac agagagaccc tctcccaaga aaaagaaaag aaccatgtca aaagaactaa
     1081 cgaaagtgtg ggaacaatgt ctcaccaatt agagaatatc aataatggga tgaaccttat
     1141 aaaaaggggc tgggcatggt ggctcatgcc tataatccca gcactttggg aggctgaggc
     1201 gggcatatca tgaggtcaag agattgagac cagcctggcc aacatggtga aaccccgtct
     1261 ctacttaaaa tacaaaaatt agccgggcgt ggtggcacgt gcctgtaatc ccagctactc
     1321 gggaggctga ggcaggagaa tcgcttgaac ccgagaggca gagattgcag tgagccgaga
     1381 ttgcaccact gcactacagc ctgggtgaca gagcgatact ccaaaaaaca aaacaaaaca
     1441 aaaaacaaaa aaaaagttta aaaaggaacc aaataaaaat tctggagttg tagggtaaaa
     1501 taaatgaaaa ttcatcccag gggcccaaga gcagattgga acaattggaa gaaagagcct
     1561 gtgactatgg agagaggcca cctgaggtag taccctctga ggaacaggaa caagcatgaa
     1621 gagcaatgca cagagatcca gagacctgga gacgccgtca agctttccga catacacgca
     1681 atgggagtcc caggaaagaa gacagggaga aaggagtaaa ggaatagttg aagaattaat
     1741 ggctgaaaaa cctcccaaat ctgatgaaaa atattaatct gtacatccaa aaagctcatc
     1801 aaactccaag tagggtaaac tcaaagagat cttcagccat acgcatcatc ataatcactg
     1861 tcaaaagaca gatttttctt tttttagaat tttaaatgta ccttttaatt tgctcctggg
     1921 gcaaagagcc aggactggta ctagagcagt gtctgggatg agaagaattt aataaaatgg
     1981 gattaggtcc aatggttggg ttaggggagg caacctgctc gggaggatca gcctcaacct
     2041 atccatgcag cagggcctcc acctgtccct ctccgtagtc ccacacctgg aacccagagc
     2101 catctgcctc ttcccagatc atggccgaca gcactccacc agactgcggc tggagcaggc
     2161 acaggattca cttattgagg gctgtggcct ggcacagatc atagcctata cccagggaca
     2221 gttgtgtcac ttctgccacc accacatccg ccttctgcag ccacatcaag taccactcat
     2281 ggatgagccc gtcaccccca gcggacttat caaccccgcg tccagctcca cagccgccac
     2341 gtgctcggtg agcactggct ccaagcatgg cagctgccat acaatccacc tgtagagggc
     2401 ccggtcctcc tgtcctcagt ggatgatccc gtagaagtcc agagctcggc agctgccctc
     2461 ccacaaaaga caggattttg aaagcagcaa gagagaagag acgtatcagg tagtcacagt
     2521 ggctcaggcc tgtaatccca gcactttggg aggcccaggt gggaggatcg cttcacccca
     2581 ggaattcaag accagcctgg acaacttgga agaacccggt ctctacaaaa aatacaaaat
     2641 tagctgggat tgggtgcggt ggctcatgcc tataatccca gcactttggg agcctgaggt
     2701 gggtggatca cctgaagtca ggagttcaag actagcctgg ccaacatggt gaaaccctat
     2761 ctctactgaa aatacaaaaa gctagacgtg gtggcacaca cctgtaatcc cagctactta
     2821 ggaggctgag gcaggagaat tgcttgaagc ctagaggtga aggttgtagt gagccgagat
     2881 tgcatcattg cacaatggag gggagccacc agcctgggca acaagaggaa atctccgtct
     2941 ccaaaaaaaa aaaaaaaaaa aaaagaatta ggctgggtgg tgcctgtagt cccagctact
     3001 tgggaggcag ggggtccact tgatgtcgag actgcagtga gccatgatcc tgccactgca
     3061 ctccggcctg ggcaacagag tgagaccctg tctaaagaaa aaaaaaataa agcaacatat
     3121 cctgaacaaa ggatcctcca taacgttccc accagatttc taatcagaaa catggaggcc
     3181 agaaagcagt ggaggaggac gaccctcagg cagcccggga ggatgttgtc acaggctggg
     3241 gcaagggcct tccggctacc aactgggagc tctgggaaca gccctgttgc aaacaagaag
     3301 ccatagcccg gccagagccc aggaatgtgg gctgggctgg gagcagcctc tggacaggag
     3361 tggtcccatc caggaaacct ccggcatggc tgggaagtgg ggtacttggt gccgggtctg
     3421 tatgtgtgtg tgactggtgt gtgtgagaga gaatgtgtgc cctaagtgtc agtgtgagtc
     3481 tgtgtatgtg tgaatattgt ctttgtgtgg gtgattttct gcgtgtgtaa tcgtgtccct
     3541 gcaagtgtga acaagtggac aagtgtctgg gagtggacaa gagatctgtg caccatcagg
     3601 tgtgtgcata gcgtctgtgc atgtcaagag tgcaaggtga agtgaaggga ccaggcccat
     3661 gatgccactc atcatcagga gctctaaggc cccaggtaag tgccagtgac agataagggt
     3721 gctgaaggtc actctggagt gggcaggtgg gggtagggaa agggcaaggc catgttctgg
     3781 aggaggggtt gtgactacat tagggtgtat gagcctagct gggaggtgga tggccgggtc
     3841 cactgaaacc ctggttatcc cagaaggctt tgcaggcttc aggagcttgg agtggggaga
     3901 gggggtgact tctccgacca ggcccctcca ccggcctacc ctgggtaagg gcctggagca
     3961 ggaagcaggg gcaagaacct ctggagcagc ccatacccgc cctggcctga ctctgccact
     4021 ggcagcacag tcaacacagc aggttcactc acagcagagg gcaaaggcca tcatcagctc
     4081 cctttataag ggaagggtca cgcgctcggt gtgctgagag tgtcctgcct ggtcctctgt
     4141 gcctggtggg gtgggggtgc caggtgtgtc cagaggagcc catttggtag tgaggcaggt
     4201 atggggctag aagcactggt gcccctggcc gtgatagtgg ccatcttcct gctcctggtg
     4261 gacctgatgc accggcgcca acgctgggct gcacgctacc caccaggccc cctgccactg
     4321 cccgggctgg gcaacctgct gcatgtggac ttccagaaca caccatactg cttcgaccag
     4381 gtgagggagg aggtcctgga gggcggcaga ggtgctgagg ctcccctacc agaagcaaac
     4441 atggatggtg ggtgaaacca caggctggac cagaagccag gctgagaagg ggaagcaggt
     4501 ttgggggacg tcctggagaa gggcatttat acatggcatg aaggactgga ttttccaaag
     4561 gccaaggaag agtagggcaa gggcctggag gtggagctgg acttggcagt gggcatgcaa
     4621 gcccattggg caacatatgt tatggagtac aaagtccctt ctgctgacac cagaaggaaa
     4681 ggccttggga atggaagatg agttagtcct gagtgccgtt taaatcacga aatcgaggat
     4741 gaagggggtg cagtgacccg gttcaaacct tttgcactgt gggtcctcgg gcctcactgc
     4801 tcaccggcat ggaccatcat ctgggaatgg gatgctaact ggggcctctc ggcaattttg
     4861 gtgactcttg caaggtcata cctgggtgac gcatccaaac tgagttcctc catcacagaa
     4921 ggtgtgaccc ccacccccgc cccacgatca ggaggctggg tctcctcctt ccacctgctc
     4981 actcctggta gccccggggg tcgtccaagg ttcaaatagg actaggacct gtagtctggg
     5041 gtgatcctgg cttgacaaga ggccctgacc ctccctctgc agttgcggcg ccgcttcggg
     5101 gacgtgttca gcctgcagct ggcctggacg ccggtggtcg tgctcaatgg gctggcggcc
     5161 gtgcgcgagg cgctggtgac ccacggcgag gacaccgccg accgcccgcc tgtgcccatc
     5221 acccagatcc tgggtttcgg gccgcgttcc caaggcaagc agcggtgggg acagagacag
     5281 atttccgtgg gacccgggtg ggtgatgacc gtagtccgag ctgggcagag agggcgcggg
     5341 gtcgtggaca tgaaacaggc cagcgagtgg ggacagcggg ccaagaaacc acctgcacta
     5401 gggaggtgtg agcatgggga cgagggcggg gcttgtgacg agtgggcggg gccactgccg
     5461 agacctggca ggagcccaat gggtgaggct ggcgcatttc ccagctggaa tccggtgtcg
     5521 aagtgggggg cggggaccgc acctgtgctg taagctcagt gtgggtggcg cggggcccgc
     5581 ggggtcttcc ctgagtgcaa aggcggtcag ggtgggcaga gacgaggtgg ggcaaagccc
     5641 tgccccagcc aagggagcaa ggtggatgca caaagagtgg gccctgtgac cagctggaca
     5701 gagccaggga ctgcgggaga ccagggggag catagggttg gagtgggtgg tggatggtgg
     5761 ggctaatgcc ttcatggcca cgcgcacgtg cccgtcccac ccccaggggt gttcctggcg
     5821 cgctatgggc ccgcgtggcg cgagcagagg cgcttctccg tgtccacctt gcgcaacttg
     5881 ggcctgggca agaagtcgct ggagcagtgg gtgaccgagg aggccgcctg cctttgtgcc
     5941 gccttcgcca accactccgg tgggtgatgg gcagaagggc acaaagcggg aactgggaag
     6001 gcgggggacg gggaaggcga ccccttaccc gcatctccca cccccaggac gcccctttcg
     6061 ccccaacggt ctcttggaca aagccgtgag caacgtgatc gcctccctca cctgcgggcg
     6121 ccgcttcgag tacgacgacc ctcgcttcct caggctgctg gacctagctc aggagggact
     6181 gaaggaggag tcgggctttc tgcgcgaggt gcggagcgag agaccgagga gtctctgcag
     6241 ggcgagctcc cgagaggtgc cggggctgga ctggggcctc ggaagagcag gatttgcata
     6301 gatgggtttg ggaaaggaca ttccaggaga ccccactgta agaagggcct ggaggaggag
     6361 gggacatctc agacatggtc gtgggagagg tgtgcccggg tcagggggca ccaggagagg
     6421 ccaaggactc tgtacctcct atccacgtca gagatttcga ttttaggttt ctcctctggg
     6481 caaggagaga gggtggaggc tggcacttgg ggagggactt ggtgaggtca gtggtaagga
     6541 caggcaggcc ctgggtctac ctggagatgg ctggggcctg agacttgtcc aggtgaacgc
     6601 agagcacagg agggattgag accccgttct gtctggtgta ggtgctgaat gctgtccccg
     6661 tcctcctgca tatcccagcg ctggctggca aggtcctacg cttccaaaag gctttcctga
     6721 cccagctgga tgagctgcta actgagcaca ggatgacctg ggacccagcc cagccccccc
     6781 gagacctgac tgaggccttc ctggcagaga tggagaaggt gagagtggct gccacggtgg
     6841 ggggcaaggg tggtgggttg agcgtcccag gaggaatgag gggaggctgg gcaaaaggtt
     6901 ggaccagtgc atcacccggc gagccgcatc tgggctgaca ggtgcagaat tggaggtcat
     6961 ttgggggcta ccccgttctg tcccgagtat gctctcggcc ctgctcaggc caaggggaac
     7021 cctgagagca gcttcaatga tgagaacctg cgcatagtgg tggctgacct gttctctgcc
     7081 gggatggtga ccacctcgac cacgctggcc tggggcctcc tgctcatgat cctacatccg
     7141 gatgtgcagc gtgagcccat ctgggaaaca gtgcaggggc cgagggagga agggtacagg
     7201 cgggggccca tgaactttgc tgggacaccc ggggctccaa gcacaggctt gaccaggatc
     7261 ctgtaagcct gacctcctcc aacataggag gcaagaagga gtgtcagggc cggaccccct
     7321 gggtgctgac ccattgtggg gacgcatgtc tgtccaggcc gtgtccaaca ggagatcgac
     7381 gacgtgatag ggcaggtgcg gcgaccagag atgggtgacc aggctcacat gccctacacc
     7441 actgccgtga ttcatgaggt gcagcgcttt ggggacatcg tccccctggg tgtgacccat
     7501 atgacatccc gtgacatcga agtacagggc ttccgcatcc ctaaggtagg cctggcgccc
     7561 tcctcacccc agctcagcac cagcacctgg tgatagcccc agcatggcta ctgccaggtg
     7621 ggcccactct aggaaccctg gccacctagt cctcaatgcc accacactga ctgtccccac
     7681 ttgggtgggg ggtccagagt ataggcaggg ctggcctgtc catccagagc ccccgtctag
     7741 tggggagaca aaccaggacc tgccagaatg ttggaggacc caacgcctgc agggagaggg
     7801 ggcagtgtgg gtgcctctga gaggtgtgac tgcgccctgc tgtggggtcg gagagggtac
     7861 tgtggagctt ctcgggcgca ggactagttg acagagtcca gctgtgtgcc aggcagtgtg
     7921 tgtcccccgt gtgtttggtg gcaggggtcc cagcatccta gagtccagtc cccactctca
     7981 ccctgcatct cctgcccagg gaacgacact catcaccaac ctgtcatcgg tgctgaagga
     8041 tgaggccgtc tgggagaagc ccttccgctt ccaccccgaa cacttcctgg atgcccaggg
     8101 ccactttgtg aagccggagg ccttcctgcc tttctcagca ggtgcctgtg gggagcccgg
     8161 ctccctgtcc ccttccgtgg agtcttgcag gggtatcacc caggagccag gctcactgac
     8221 gcccctcccc tccccacagg ccgccgtgca tgcctcgggg agcccctggc ccgcatggag
     8281 ctcttcctct tcttcacctc cctgctgcag cacttcagct tctcggtgcc cactggacag
     8341 ccccggccca gccaccatgg tgtctttgct ttcctggtga gcccatcccc ctatgagctt
     8401 tgtgctgtgc cccgctagaa tggggtacct agtccccagc ctgctcccta gccagaggct
     8461 ctaatgtaca ataaagcaat gtggtagttc caactcgggt cccctgctca cgccctcgtt
     8521 gggatcatcc tcctcagggc aaccccaccc ctgcctcatt cctgcttacc ccaccgcctg
     8581 gccgcatttg agacaggggt acgttgaggc tgagcagatg tcagttaccc ttgcccataa
     8641 tcccatgtcc cccactgacc caactctgac tgcccagatt ggtgacaagg actacattgt
     8701 cctggcatgt ggggaagggg ccagaatggg ctgactagag gtgtcagtca gccctggatg
     8761 tggtggagag ggcaggactc agcctggagg cccatatttc aggcctaact cagcccaccc
     8821 cacatcaggg acagcagtcc tgccagcacc atcacaacag tcacctccct tcatatatga
     8881 caccccaaaa cggaagacaa atcatggcgt cagggagcta tatgccaggg ctacctacct
     8941 cccagggctc agt
//

