LOCUS       NG_008055              12238 bp    DNA     linear   PRI 25-MAR-2012
DEFINITION  Homo sapiens myelin protein zero (MPZ), RefSeqGene on chromosome 1.
ACCESSION   NG_008055
VERSION     NG_008055.1  GI:190570180
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12238)
  AUTHORS   Luo,X., Sharma,D., Inouye,H., Lee,D., Avila,R.L., Salmona,M. and
            Kirschner,D.A.
  TITLE     Cytoplasmic domain of human myelin protein zero likely folded as
            beta-structure in compact myelin
  JOURNAL   Biophys. J. 92 (5), 1585-1597 (2007)
   PUBMED   17142269
REFERENCE   2  (bases 1 to 12238)
  AUTHORS   Pham-Dinh,D., Fourbil,Y., Blanquet,F., Mattei,M.G., Roeckel,N.,
            Latour,P., Chazot,G., Vandenberghe,A. and Dautigny,A.
  TITLE     The major peripheral myelin protein zero gene: structure and
            localization in the cluster of Fc gamma receptor genes on human
            chromosome 1q21.3-q23
  JOURNAL   Hum. Mol. Genet. 2 (12), 2051-2054 (1993)
   PUBMED   7509228
REFERENCE   3  (bases 1 to 12238)
  AUTHORS   Hayasaka,K., Himoro,M., Sato,W., Takada,G., Uyemura,K., Shimizu,N.,
            Bird,T.D., Conneally,P.M. and Chance,P.F.
  TITLE     Charcot-Marie-Tooth neuropathy type 1B is associated with mutations
            of the myelin P0 gene
  JOURNAL   Nat. Genet. 5 (1), 31-34 (1993)
   PUBMED   7693129
REFERENCE   4  (bases 1 to 12238)
  AUTHORS   Hayasaka,K., Himoro,M., Wang,Y., Takata,M., Minoshima,S.,
            Shimizu,N., Miura,M., Uyemura,K. and Takada,G.
  TITLE     Structure and chromosomal localization of the gene encoding the
            human myelin protein zero (MPZ)
  JOURNAL   Genomics 17 (3), 755-758 (1993)
   PUBMED   7503936
REFERENCE   5  (bases 1 to 12238)
  AUTHORS   Hayasaka,K., Nanao,K., Tahara,M., Sato,W., Takada,G., Miura,M. and
            Uyemura,K.
  TITLE     Isolation and sequence determination of cDNA encoding the major
            structural protein of human peripheral myelin
  JOURNAL   Biochem. Biophys. Res. Commun. 180 (2), 515-518 (1991)
   PUBMED   1719967
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Valerie Delague. The reference sequence was
            derived from AL592295.25.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a major structural protein of peripheral
            myelin. Mutations in this gene result in the autosomal dominant
            form of Charcot-Marie-Tooth disease type 1 and other
            polyneuropathies. [provided by RefSeq, Apr 2010].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12238             AL592295.25        26403-38640         c
FEATURES             Location/Qualifiers
     source          1..12238
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            complement(<1..597)
                     /gene="SDHC"
                     /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3"
                     /note="succinate dehydrogenase complex, subunit C,
                     integral membrane protein, 15kDa"
                     /db_xref="GeneID:6391"
                     /db_xref="HGNC:10682"
                     /db_xref="MIM:602413"
     mRNA            complement(<548..597)
                     /gene="SDHC"
                     /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3"
                     /product="succinate dehydrogenase complex, subunit C,
                     integral membrane protein, 15kDa, transcript variant 1"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_003001.3"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_003001.3"
                     /db_xref="GI:78711818"
                     /db_xref="GeneID:6391"
                     /db_xref="HGNC:10682"
                     /db_xref="MIM:602413"
     mRNA            complement(<548..597)
                     /gene="SDHC"
                     /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3"
                     /product="succinate dehydrogenase complex, subunit C,
                     integral membrane protein, 15kDa, transcript variant 2"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_001035511.1"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_001035511.1"
                     /db_xref="GI:78711819"
                     /db_xref="GeneID:6391"
                     /db_xref="HGNC:10682"
                     /db_xref="MIM:602413"
     mRNA            complement(<548..597)
                     /gene="SDHC"
                     /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3"
                     /product="succinate dehydrogenase complex, subunit C,
                     integral membrane protein, 15kDa, transcript variant 3"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_001035512.1"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_001035512.1"
                     /db_xref="GI:78711821"
                     /db_xref="GeneID:6391"
                     /db_xref="HGNC:10682"
                     /db_xref="MIM:602413"
     mRNA            complement(<548..597)
                     /gene="SDHC"
                     /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3"
                     /product="succinate dehydrogenase complex, subunit C,
                     integral membrane protein, 15kDa, transcript variant 4"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_001035513.1"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_001035513.1"
                     /db_xref="GI:78711823"
                     /db_xref="GeneID:6391"
                     /db_xref="HGNC:10682"
                     /db_xref="MIM:602413"
     CDS             complement(<548..567)
                     /gene="SDHC"
                     /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_002992.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; succinate-ubiquinone oxidoreducatase cytochrome
                     B large subunit; integral membrane protein CII-3;
                     cytochrome B large subunit of complex II; succinate
                     dehydrogenase cytochrome b560 subunit, mitochondrial;
                     integral membrane protein CII-3b; QPs-1; succinate
                     dehydrogenase complex subunit C; succinate-ubiquinone
                     oxidoreductase cytochrome B large subunit"
                     /codon_start=1
                     /product="succinate dehydrogenase cytochrome b560 subunit,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_002992.1"
                     /db_xref="GI:4506863"
                     /db_xref="CCDS:CCDS1230.1"
                     /db_xref="GeneID:6391"
                     /db_xref="HGNC:10682"
                     /db_xref="MIM:602413"
     CDS             complement(<548..567)
                     /gene="SDHC"
                     /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_001030588.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; succinate-ubiquinone oxidoreducatase cytochrome
                     B large subunit; integral membrane protein CII-3;
                     cytochrome B large subunit of complex II; succinate
                     dehydrogenase cytochrome b560 subunit, mitochondrial;
                     integral membrane protein CII-3b; QPs-1; succinate
                     dehydrogenase complex subunit C; succinate-ubiquinone
                     oxidoreductase cytochrome B large subunit"
                     /codon_start=1
                     /product="succinate dehydrogenase cytochrome b560 subunit,
                     mitochondrial isoform 2 precursor"
                     /protein_id="NP_001030588.1"
                     /db_xref="GI:78711820"
                     /db_xref="CCDS:CCDS41431.1"
                     /db_xref="GeneID:6391"
                     /db_xref="HGNC:10682"
                     /db_xref="MIM:602413"
     CDS             complement(<548..567)
                     /gene="SDHC"
                     /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_001030589.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; succinate-ubiquinone oxidoreducatase cytochrome
                     B large subunit; integral membrane protein CII-3;
                     cytochrome B large subunit of complex II; succinate
                     dehydrogenase cytochrome b560 subunit, mitochondrial;
                     integral membrane protein CII-3b; QPs-1; succinate
                     dehydrogenase complex subunit C; succinate-ubiquinone
                     oxidoreductase cytochrome B large subunit"
                     /codon_start=1
                     /product="succinate dehydrogenase cytochrome b560 subunit,
                     mitochondrial isoform 3 precursor"
                     /protein_id="NP_001030589.1"
                     /db_xref="GI:78711822"
                     /db_xref="CCDS:CCDS44263.1"
                     /db_xref="GeneID:6391"
                     /db_xref="HGNC:10682"
                     /db_xref="MIM:602413"
     CDS             complement(<548..567)
                     /gene="SDHC"
                     /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_001030590.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; succinate-ubiquinone oxidoreducatase cytochrome
                     B large subunit; integral membrane protein CII-3;
                     cytochrome B large subunit of complex II; succinate
                     dehydrogenase cytochrome b560 subunit, mitochondrial;
                     integral membrane protein CII-3b; QPs-1; succinate
                     dehydrogenase complex subunit C; succinate-ubiquinone
                     oxidoreductase cytochrome B large subunit"
                     /codon_start=1
                     /product="succinate dehydrogenase cytochrome b560 subunit,
                     mitochondrial isoform 4 precursor"
                     /protein_id="NP_001030590.1"
                     /db_xref="GI:78711824"
                     /db_xref="CCDS:CCDS41432.1"
                     /db_xref="GeneID:6391"
                     /db_xref="HGNC:10682"
                     /db_xref="MIM:602413"
     STS             852..993
                     /standard_name="AL033654"
                     /db_xref="UniSTS:93489"
     STS             4998..5170
                     /standard_name="GDB:567202"
                     /db_xref="UniSTS:157711"
     gene            5001..10238
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /note="myelin protein zero"
                     /db_xref="GeneID:4359"
                     /db_xref="HGNC:7225"
                     /db_xref="MIM:159440"
     mRNA            join(5001..5134,7549..7715,8052..8265,8509..8644,
                     8805..8865,8996..10238)
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /product="myelin protein zero"
                     /transcript_id="NM_000530.6"
                     /db_xref="GI:295391070"
                     /db_xref="GeneID:4359"
                     /db_xref="HGNC:7225"
                     /db_xref="MIM:159440"
     exon            5001..5134
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(5068..5134,7549..7715,8052..8265,8509..8644,
                     8805..8865,8996..9097)
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /note="Charcot-Marie-Tooth neuropathy 1B; myelin protein
                     P0; myelin peripheral protein"
                     /codon_start=1
                     /product="myelin protein P0 precursor"
                     /protein_id="NP_000521.2"
                     /db_xref="GI:295391071"
                     /db_xref="CCDS:CCDS1229.2"
                     /db_xref="GeneID:4359"
                     /db_xref="HGNC:7225"
                     /db_xref="MIM:159440"
     STS             7488..7796
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /standard_name="GDB:567206"
                     /db_xref="UniSTS:157712"
     exon            7549..7715
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     STS             7565..8077
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /standard_name="GDB:453314"
                     /db_xref="UniSTS:157411"
     STS             7668..7841
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /standard_name="AL009353"
                     /db_xref="UniSTS:81171"
     exon            8052..8265
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     STS             8057..9065
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /standard_name="GDB:453316"
                     /db_xref="UniSTS:157412"
     STS             8412..8721
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /standard_name="GDB:567212"
                     /db_xref="UniSTS:157713"
     exon            8509..8644
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     STS             8733..8979
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /standard_name="GDB:567216"
                     /db_xref="UniSTS:157714"
     exon            8805..8865
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     STS             8959..9181
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /standard_name="GDB:567273"
                     /db_xref="UniSTS:157716"
     exon            8996..10238
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     STS             9336..9584
                     /gene="MPZ"
                     /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E;
                     CMTDI3; DSS; HMSNIB; MPP; P0"
                     /standard_name="G15925"
                     /db_xref="UniSTS:37164"
     STS             9405..10268
                     /standard_name="MPZ_930"
                     /db_xref="UniSTS:462348"
ORIGIN      
        1 agcagaggtc cgccctgggt gctaatgcta atcgccaccc cagtagggat ccaccctttg
       61 ccagcagccc gctgggaacc cagacagcgc ccactcacgg tgggagcagc tagtgtctga
      121 aggcattcga agcaaaggca aaatacacga agatctctct ctccgaagct aaatgtctaa
      181 atacgctctc gaaatcgtag gacccatggg tggctgacct tgaagttatt ttctcagagc
      241 tcggctctgg gtgcaggccc gagagcaatt tgcgttagaa gtactagagg aggtggggaa
      301 aacagaaggg gcgagagccg agggcccctc gatacgaagt cagtgacccc gaagccctac
      361 ggagcgcacc ggagcggctg ggggggacgg gaaaaggggt ctctaggatc cccgagcgct
      421 tggcctccac acccatgggt cctttccctg cccaggcaca ggataaacag ttatcagcaa
      481 aacgtgaggg gccagttcag atctccggag ggccgcaggc accaactccc agtcccactg
      541 aagtcacctc agcaacagcg cagccatctt gggttccggt ctggacggaa gtgacgccag
      601 gcggccccgc cacccgaggg cggaggcgcg ccggctgggg gtcggggttg ggggtgtcat
      661 gtgacgagag tctctttaaa aggctctgga gcttctccgc tcagctctgc ctagctggtt
      721 tgctggttgt tttctggttt tttagtctcc tcctccgcct cctgcagccg acttctaccg
      781 gaatttgcca ggatttcggc agaaacgccg ctggctcaaa atctgcagtc tacgttccac
      841 ctgcgtacat attcattttg tatcgcactc ccaaacagca aacggcggac ttgtttagat
      901 tcttccttaa ggacttcgca gtctgttgcg ttccccctgc ctcccaggtc ggcctaaaaa
      961 cgtggtggtt ggccggttga gaccccgaag agaaaagata ctttgggttc cctccctttc
     1021 taatacgaag ctttaaccag acagatacat aaattgtgac ctaagttggg gagtgtgtag
     1081 aggggcctcg agaagacctt gcggaccacc attcccgaaa acgaggagcc tcatctaacc
     1141 acctcgatta gaccccacaa ttcctgggtt tgagctgcca catggaccag gcgcccacta
     1201 gccgaggaca atgctccctt gttcgttgtt tcagcgctat gtgggtgaca cccacagcta
     1261 gaagaacccg gagtgagggg aagaacacgc tttgatttat atatgtgtat atatatatat
     1321 acagttttag ggaacccaag cacaggaatc aactgccgag cactcaagac tgaagaaaga
     1381 agaagagcaa atgataaagg aagggaacag agcacaaaag ttcttgactc ttgtggggag
     1441 tagggtggag aggagtaaaa gggacaggct agagcaactc ctatttctac aaaaaaaata
     1501 ctcaattata ttaatattca gatcttatgt atatttagca tccctgcact tcaggattta
     1561 aatagcacaa attcacttat ttctgcatca gatgaataat actactttgc atttctataa
     1621 tgcttgacaa agcacattcg tacactttag gattgaaaga ggctctctaa tccaatctac
     1681 tatctatgca gggatctcct ctgcaacacc cataacagct gatcttcaag actctacccc
     1741 cccatattca atgatgggta cctcaaacaa caagttttat ttaatgaaca acttattcgt
     1801 tagttattat atttaaatac agttttgtgc tatcgaaatt ccagtcattg acttggctct
     1861 ctggagcttc acgttaacaa acccaaggaa tgcctttttc actcagatct tttttggttt
     1921 ttctttttct ttttcttttt cttttatttt gagacgtagt ctcactctgt cgcccaggtt
     1981 ggagtgcagt ggcgctatct cagctcactg cagcctctgc ctcccaggtt caagcgattc
     2041 tcctgcctca gcctcccccc aagtagctgg gattacaggc ctgcaccacc atgcccggct
     2101 aattttctgt atttttagta gagatggaat ttcaccatgt tggctaggct ggtctagaac
     2161 tcctgacctc aagtgatcca ccggcctcgg cctcccaaag tcctgggatt ataggtgcga
     2221 gctaccactc ccagcccact cagctcttta aatattaata atttcattta gcatgtagtt
     2281 atggactttt tgtcagtccg tgaaaagttc tgtaggggat tcaaagatac agatgtttgt
     2341 actgtcccca agaaggttat agccttagca ggatcaataa agacatgcaa caaagaaagt
     2401 agcaacaacc cattgaagag ggtgttgata aaaggggtgg ttagataaag aggaaatgat
     2461 tgcttacagt tgggaggtgg agttaggtgg aaattttgga ggggagagtt ttgggggttt
     2521 tttttttttt gtactttgaa ttgctgtttt atagaaatgt tgactacaac atcctgtaaa
     2581 catttgtcaa tgatgatggt tttgcctatg gacttcataa gcaatcccat atttagaatt
     2641 ccacaaccca aatctaatac taatgaccat acccaccagg gctgtggtct aatgagatgc
     2701 caggaaggta ccaggacact gtccttcacc tgggtgagcc tgcagtggtc tcatagcagg
     2761 aataacaatg accaccccac ttacattaac ttctagaggt caggcacggt gactcacacc
     2821 tgtaatccca gtacttaggg aagccaaggc agaaggatca cttgagtata ggagttcaag
     2881 atcaacctga gcaacacagt gagatcctca tctctacaaa aaattgaaaa attagctggg
     2941 tatggtggtg gctgcctgtg gctcagctaa tctggaggct gaagtgggag gatcgcttga
     3001 gcctgggagg ttgaggctgc agtgagctat cattgcacca ctgcactaca gcctgggcca
     3061 cagagcaaga ccttatctct gaaaaaaaaa aaaaaaaaat tttaaactag cccagcatgc
     3121 tggcatgcgc ctgtagttcc cagctacttg gaaagctgag gtaggacaat tgcttgagcc
     3181 tcagaggtca aggctgcagt gagccatgat catgccactg cattccagcc tgggcaacag
     3241 agcgagactg cctcaacaaa caaaaaaacc tcagctctgg ttatgtagac atccccatgg
     3301 ctaactccac cccaacacct tcaggttctc atgatgtacc aaattgaatt caccttcttt
     3361 cacctgtcat ttaaggcctt tcacaaactg gtttcgactt tcctgtccag tctcatttct
     3421 gactatgcca cttcaagttt ccccaaatca agtcaaagtg gatggcacaa gatcggccct
     3481 gaatatatcc aacacttcag aaacctacat ctcatataca tacacacaca cacacacaca
     3541 cacacacaca cacacacaca cacacacaca cacattctgt ctctccgtct cacctctttg
     3601 tccttgcttt tgctgttcta tcttctggta accctcccta tctccctttc caaaatgaca
     3661 gtcatccttc aaggctgatt catatctaac attgcctcct agacacaact attcttccct
     3721 ctgaactatt tatttgtttg attatttatt tatttattta tttttgagac agagtttcat
     3781 tctgtagccc agggtggaaa gcagtggcac aatcatagct cgctgcagcc ttgatttccc
     3841 aggttcaagc gatcttcctg cctcagcctc ccaagtagct gggactacaa gcatgtgata
     3901 acatgcccag ctgatttttt aaaaaatttt ggtagaggcg aggtcttgct atgttgccca
     3961 gacaggtctc aaactcctaa actcaagcaa tcctcctgca taagcctacc aaagtgctga
     4021 gattacaggt gtcagccact atgcctggca taaacttcat ttattaaagt ttattttgtc
     4081 tttaatctct catataactt agtcttcctg atattgcagc tgtgtgtgcc cctcttttgt
     4141 actcccagca ttttgttcat tactaaagga agtgtcatgg cttattatac ttgattgttg
     4201 atgggtttgt cctctgatct tcccatctcc acctccccaa accaaatttt caactccttg
     4261 ctggaaggac ttaattttta ttcctctctc tattacctgc attctcatac tttacatatt
     4321 gctggcactt aatacaattt tgtagccttg aaataaattg aaatggactt aaacagcagc
     4381 atgaagcact gaaggacttc ttgacaaacg gaaaggtcag gggcttcttg cctggaaata
     4441 gtccagtgga gaaaaacttc tgtctgggaa gaatcgcaca ggatgaaggg aggtgcgggg
     4501 aaaaaaactc ccataggact tggtcatctc aagaagtctg taatgcagcc cacattagag
     4561 gagataacag gggatatcct attttcagag ttctctgggg gaaacctccc tctagttcct
     4621 agggctgtga ggcagcctct ctcaggcaag gaggctgagg agaaatccct ttttatggcc
     4681 tttaaattga ggttccatat ctatccctca gagaagtgtg tctgtgtccc tgtttttgtc
     4741 cctctccctc accacccccc acaacattcc agcctggggc agggggaggc cagtggacac
     4801 aaagccctct gtgtatgggg tggtatgtgt ccccccaccc ctccacccag actatacaat
     4861 gccccttctg ctccctgcac tctgcccccc tccccaccac ctctcaactg cacatgccag
     4921 gctgcaattg gttactggct gaggacagcc ccctcatgct ggggccctag gggattttaa
     4981 gcaggttcca ggaacccccc gttcagttcc tggtccccca ctttctcaac cccacagatg
     5041 ctccgggccc ctgcccctgc cccagctatg gctcctgggg ctccctcatc cagccccagc
     5101 cctatcctgg ctgtgctgct cttctcttct ttgggtaagt ggagccactc tactctggga
     5161 gtcttgggac tcaggtgtct ctcagcaatc cccacagcct ttgctgcact ccccactgca
     5221 accaaagaaa gaacaagcag gagcaggaag gtgacattat attcagaaag aaaaaatatg
     5281 cggctgggca tggtggctca tgcctgtaat cccagcactt tgggaggcca aggtgggata
     5341 attatttgag ccccaggagt tggagaccag cctggacaac ataaccagac tccatctgta
     5401 aaattcaaaa aaaaaaaaaa tatatatata tatatatgaa aagaaaaaaa tatgcattta
     5461 gagggaggaa gtagaggttt tattttaaaa gaaagggtaa aagagagtgt agcaagcttc
     5521 cctgagtggt ggccatggct ggacccaggt tggaaatagt agcatgcccc cagagccatg
     5581 ctaacagcct ggtgggaagc agtgttagat tacataaaga aataggctca aacacctggg
     5641 tttggttccc actcgtcccc tagcagtgca ggaggtgcct taaccttagt ttcccagaag
     5701 gaaaaagaga gtgcgatcta agtaaggagc ccaggtttgt ggtctcagct cctcagattt
     5761 tttgtctctc tatggctcct cacctgttgt gtgggtgaat ggagtgaggt tctatgagat
     5821 tctgggatct tatccctcta aagctgtctt ccttcataag ctgaccagcc ctttccttgc
     5881 cccctggcag atgttgggtg agtaagaggt caaagcagga ttattggaat ggccccttcc
     5941 cttctctgaa ctgccctgaa tcctagtgca atgagtgagc cataggcaag tgggggtggt
     6001 ggggaggaca tcaagggaaa gggggctggc cagaatgccc agggttctct gctgtcagct
     6061 gcttgagccc tagactcttc tgggttgtac tgggctattt gggggtaccc tgagaaaatg
     6121 ttaaagatag agagttggag aagggcatag tgagggaaat agggggaagg aatcttgatg
     6181 tataaggaag agggagagtt gtgtctcaac acttgttcca ctcatagaac cattgagcac
     6241 agctgagaag ggcaatggtt gatattgtaa caggaggaat agaagttaga gccagtgaat
     6301 tatctccctt gttaaacaag ggggattccc aagaaggttc taaggtggaa gttccagaag
     6361 gtaagtacat ggtattgcat gctgaggtga gagattcagg acagttgggg tgggagtagg
     6421 ggtggcatga gccccccagc gttggtcaga caatggaact ttgtttggtt gccacctccc
     6481 cctcctgtag aacaaaaagg tctacagttg cccctccctg gggccagccc acacacatag
     6541 tctctctgga atgaccttcc ttgtgtgggt aagtcttggg gatggcactg ggccacagtg
     6601 gccaagagga aggtgaggac agttgaacca tagagggctc acatgtaggg tcatctgagc
     6661 tgtaggcttg gggtgttgct ctgcacccag ctgagagggg tatgaggccc ttcccttcct
     6721 gactctccag tcaagagcaa gctgtatggc aaccagggat tcagcaatga ggacagttgt
     6781 gccagggaag aagacttata ttttctagtt atcttcattt ttttctgcaa gaaatctgag
     6841 tttgctgtat tgtgaaatcc aatgcagctg ttaaaataag attgatatct atgaatcaac
     6901 agggaaagct cctccagata cgtaagttct taagcaaaaa gacactagaa tacaatgcaa
     6961 tatgtatgtg gaaaaaaaaa ctccacaaaa ctatttgttg taagtatgtg tatatcttga
     7021 gtttattgag tttatactga gtttgattca tattaaatgg ataacttgtt acatcttgga
     7081 agggaataca ggaaaggaat ttgttgggct aagtgtcaaa ggagactttt gttttatttc
     7141 tattgcttga atagtttata agaagagtac aatatgtatt acctgtataa tttataataa
     7201 attttaaaaa tttagaacac tgcatctaaa ggatagctta aaagttagat actgacccaa
     7261 aggagaagtg agacttaaag acagaaccca atctctggaa gtcctcaaga gaattctgtt
     7321 actgctgatt tcatcttctc tacagacatg ctaaagagct tgacagacac agcatttatg
     7381 ctcatctgtt cagttagtcc ccagagactt ggggctcaga atttgttgtt tcttttccaa
     7441 attggcctct gacctgtgac tcagcacttg atttcctact gatctcactt cctctgtatc
     7501 ccttactggg cccataggtg catctgattc cccactttgt gcttgcagtg ctgtccccgg
     7561 cccaggccat cgtggtttac accgacaggg aggtccatgg tgctgtgggc tcccgggtga
     7621 ccctgcactg ctccttctgg tccagtgagt gggtctcaga tgacatctcc ttcacctggc
     7681 gctaccagcc cgaagggggc agagatgcca tttcggtgag tgcctggggg aatcctgggg
     7741 ttggataaca gaaagtgctt caaagaacaa caaaaaagat aacttgggct aaggaggggg
     7801 aaatcctttt tgagccataa ccccaacttt ggcaaggtaa atgacagtct ttgtcaccct
     7861 gactacattg tcctcccttc tccagcacta ccctttccag cccaagatcc cttaccctga
     7921 ggctggagcg aagctttttt tttttttttt ttttttttgc ttttttcttt ctgtaacaaa
     7981 ttatggagct aagctttgac agctgtgttc tcattagggt cctctcacat gcttcccctc
     8041 attcctcata gatcttccac tatgccaagg gacaacccta cattgacgag gtggggacct
     8101 tcaaagagcg catccagtgg gtaggggacc ctcgctggaa ggatggctcc attgtcatac
     8161 acaacctaga ctacagtgac aatggcacgt tcacttgtga cgtcaaaaac cctccagaca
     8221 tagtgggcaa gacctctcag gtcacgctgt atgtctttga aaaaggtgtg agaagggatg
     8281 gggacaaggg tatgggaagc agtttgggag gggatcaggg aggactgata ggttggggga
     8341 agaggcaaaa agcccggcct aaggaccttt attcaggctc tgggagcgtg ggcagaaggc
     8401 agttttagct gggagtccta catcctcaat gcagggcata cactcggact aggaaccaca
     8461 gatacagggc cctgctcatt ctcccacttc ttttcccacc cctcctagtg ccaactaggt
     8521 acggggtcgt tctgggagct gtgatcgggg gtgtcctcgg ggtggtgctg ttgctgctgc
     8581 tgcttttcta cgtggttcgg tactgctggc tacgcaggca ggcggccctg cagaggaggc
     8641 tcaggtaagg ggcggagcct agctcccctc cccctctccc cactatcccc catctgggcg
     8701 gagactactc cagtgggtgg gagggccaag gggaagagga agctgtgtcc gcggtgcaag
     8761 gggttccggc gaggccaaac gtacagcagt ctctcttctt gcagtgctat ggagaagggg
     8821 aaattgcaca agccaggaaa ggacgcgtcg aagcgcgggc ggcaggttag cgggacttgg
     8881 ggcctagaca agatgggaag gagaaccctg ggagccgccg ggcagcagtg aggggtggga
     8941 tgggaacagt caagccccag tcgctcggtg actgatgtgt gcgcccctcc cccagacgcc
     9001 agtgctgtat gcaatgctgg accacagcag aagcaccaaa gctgtcagtg agaagaaggc
     9061 caaggggctg ggggagtctc gcaaggataa gaaatagcgg ttagcgggcc gggcggggga
     9121 tcgggggtta ggggtggagt ccgccaaagg cccaaaggtg atggtcatcg agatggagct
     9181 acgaaaggat gagcagagcc cggagctccg gcctgctgtc aagtccccca gcagaaccag
     9241 cctcaaaaac gccctcaaga acatgatggg cctgaactcg gacaagtgat cgccaccccc
     9301 ccaccccagg ccctgccaga gcagggggac ctaggctcct cttacccccg tctaggtgct
     9361 ttccctcttt gctcccccgc cctgccctgc cctcacctcc ctttgagatg taagtttcat
     9421 tccagaattc attccccagg caattgtatt ctcccccacc ttcacccctg gctttctggg
     9481 agcccaggag ctaatcctac ccctcacctg ccccgggggc tgtgtgtttg gtgcctgtcc
     9541 acctgagcac tgagaagaaa gggactttga taccctctgc ctcaagtcca ggccacctgg
     9601 cattcccatc tcctgcatcc cccagcctgt ccccctggct gtttcctctc ccgtccctcc
     9661 ctcccctcta ccaggtggcc cagctccata ctctgtcccc ccagctaata cccagagcac
     9721 ccagatcaga ctctccttca gggtttattt aggttattat tttttatttt ttaatccatt
     9781 ctttgtttgt ttacctgtgc tcatcctctg cccttacacc catgactgag gaccaatgac
     9841 gtcatgtggc ttttgcaatt cacgcccccc ttaagtcctt aatgaagagc cagcccaagt
     9901 agaggggccc ctgatcctca cacttcagta tagcattggt tccccctgac cactttggag
     9961 cactgttctg ggactccagg tcttgaggag agagacagag agagagaatg gatcctcata
    10021 ggtcagggag tgggggaggg ggcaaatgag ccttaagaaa tggtttttaa acaaccaaac
    10081 aaaaagcagg aaaaacaaat gggaaatggg ggggcggggg ggaggaagag gctgcactgc
    10141 agccacaggg gattcttagg atttttctac attctgtata tttcttctca aacctccaaa
    10201 tgtccttaaa tgtttaataa acactgacat ttccagaagc tgctgccttg tctagaattt
    10261 cctagtcctc ctgggaataa ttcctgcccc ttatcccatc cccaaccttc catacttggc
    10321 ttcagttgtt tagtttgttt ttttggggtg ggcttatata gtatactaga aagaactctg
    10381 aaatagcctc acaagacaca ttcatacctt cagcaaataa tcagtgagat tatactacgt
    10441 tgtaaactct gccagtctct gcttttacat gagttaaaac gcagaatctg tcttcaccaa
    10501 gatctgaatt ttaaaacatc ccagccactc tctagctgtg tgatccccag gacagttacc
    10561 tgactttggt aagcttgttt atgtacttgt aaacaactga gataatgata tctgccctgc
    10621 ttaattccta gggattttat aataatcaaa tgagatcctg tgtatggaaa actttgtaaa
    10681 ctgtaagttg atatacaact aaatattaag gtgttcaata tttgtttcta gtgcttgcct
    10741 aaggtagtac actttacaaa ttagcacaaa tcccattcac ctctctaaac aatcactgct
    10801 ttgttttgtt ggtacatgat tttacttctg tttacctatt aataggtata ctattaatac
    10861 ctcattagct agtttgttgg tatgttgatt taggtatacc attaatatcc tggtatcctg
    10921 aactgattgt ggaaaaacat atacgtatca ttttcccctg gggattactg atggcacaaa
    10981 aaaacccaaa gtgcccacaa gtaatttctt ccccttgtta agaagctaaa gatatgatta
    11041 acaccagctt taccaaaacc cagagtgctt ccatttgttt gaggggtgtc ttcaatgtct
    11101 tttaaaaaaa atcaatctgc cttcatttaa atataaaagc taatagagta tatatagcct
    11161 tttgttgggg ggaagtggga gaggaaactt agtcacaacc cagtaataaa gttgggaata
    11221 tcttaagccc aagattcctt attagttaag atgctaaact gtccattatt cattagatag
    11281 ttgcagctgg gttccctgct taaacttccc agactgtcag gagagtcaaa tgaggttgga
    11341 tgtggtggct catgcctgta atgccagcac tttgggaggc cgaggtgggc agatcacttc
    11401 aggctaggag gttgaggcca gcctgaccaa catggctaaa cactgtctcc actaaaaata
    11461 caaaaattag ccgagcatgg tggtgaacgc cttctaaccc tggctacttg ggcagctggg
    11521 gcacgagaat tgcttgaacc gcggaggcgg aggttgcagt gagccgagat catgccgctg
    11581 cactctagcc tgggcaacac agcgagacta tgtctcataa aaataaaaaa gaaagagaga
    11641 gagagagagt caaatgaaat attatgctac ttatgagata gagtatagct caaagcttct
    11701 catttaatta cacttttgtt ctaaaattta tcagccacct gcattttgct agctcagttt
    11761 atccaattat tttaatattt cttattccat caagaatcct ggtaccctgg gacaacattt
    11821 tgcaatctct tgcattaggc attttcacaa gcattgcaca cttaatgtgg gtttttccag
    11881 gactgtgccc attttccaca atccccaaca aagtaagcca catcccccct ttctttcctc
    11941 tgcagtaaag cattaaataa agtctagaat aatgattcag ataaagggaa atgacattgt
    12001 tatatgggaa actttgaatc ccatctaatt attactttga aataaatcgt tcacaatcct
    12061 cagtgcgttg ttaataatag caataatttt gcccaggcat gtgagcactt tgagaataat
    12121 ttaaagcctt tttcagtgtt aaccataaaa agaaaaagat tataacccaa tttatgaata
    12181 cgcagacaaa gagtctaaat aaaatatttg caaaagagaa ttccacaatg agttaata
//

