LOCUS       NG_027758               7784 bp    DNA     linear   PRI 02-APR-2012
DEFINITION  Homo sapiens heat shock 27kDa protein 3 (HSPB3), RefSeqGene on
            chromosome 5.
ACCESSION   NG_027758
VERSION     NG_027758.1  GI:307611937
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7784)
  AUTHORS   Sugiyama,Y., Suzuki,A., Kishikawa,M., Akutsu,R., Hirose,T.,
            Waye,M.M., Tsui,S.K., Yoshida,S. and Ohno,S.
  TITLE     Muscle develops a specific form of small heat shock protein complex
            composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation
  JOURNAL   J. Biol. Chem. 275 (2), 1095-1104 (2000)
   PUBMED   10625651
REFERENCE   2  (bases 1 to 7784)
  AUTHORS   Boelens,W.C., Van Boekel,M.A. and De Jong,W.W.
  TITLE     HspB3, the most deviating of the six known human small heat shock
            proteins
  JOURNAL   Biochim. Biophys. Acta 1388 (2), 513-516 (1998)
   PUBMED   9858786
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092366.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a muscle-specific small heat shock
            protein. A mutation in this gene is the cause of autosomal dominant
            distal hereditary motor neuropathy type 2C.[provided by RefSeq, Sep
            2010].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7784              AC092366.3         139358-147141
FEATURES             Location/Qualifiers
     source          1..7784
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            5001..5784
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HSPL27"
                     /note="heat shock 27kDa protein 3"
                     /db_xref="GeneID:8988"
                     /db_xref="HGNC:5248"
                     /db_xref="MIM:604624"
     mRNA            5001..5784
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HSPL27"
                     /product="heat shock 27kDa protein 3"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_006308.2"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_006308.2"
                     /db_xref="GI:306966173"
                     /db_xref="GeneID:8988"
                     /db_xref="HGNC:5248"
                     /db_xref="MIM:604624"
     exon            5001..5784
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HSPL27"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     STS             5082..5740
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HSPL27"
                     /db_xref="UniSTS:486904"
     STS             5087..5890
                     /standard_name="HSPB3_202"
                     /db_xref="UniSTS:280770"
     STS             5146..5693
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HSPL27"
                     /db_xref="UniSTS:494604"
     STS             5153..5689
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HSPL27"
                     /db_xref="UniSTS:482422"
     CDS             5190..5642
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HSPL27"
                     /note="protein 3; HSP 17; heat shock 17 kDa protein"
                     /codon_start=1
                     /product="heat shock protein beta-3"
                     /protein_id="NP_006299.1"
                     /db_xref="GI:5453688"
                     /db_xref="CCDS:CCDS3961.1"
                     /db_xref="GeneID:8988"
                     /db_xref="HGNC:5248"
                     /db_xref="MIM:604624"
     STS             5550..5671
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HSPL27"
                     /standard_name="RH65243"
                     /db_xref="UniSTS:85914"
ORIGIN      
        1 aacctttcca cctggaaaga gactgcacct cccagggctg gccaatcctt agagacagca
       61 aagggctcag ctgggagtgt gcctttgata cgcaaactgc ccaacccaga gccatctctc
      121 ctctatgtgg cccctgcact ccaggacaca acattcctct gccttagtca accaaaggcc
      181 aggtaccggg caattggaga catcctgtag cttagggcct gctgaaatta ttcaaactag
      241 ccagttctaa actgttcatc ctgccctgcc tttccctgtg gaaaccccaa taatggctgt
      301 ggctaaatct tccacttgct cctgtcttct gcctcctgac tgcttatgtc ttcctctcac
      361 cctccatagc cagttgtctc taggacctgt gagtataaca tactttgttt tcccgagact
      421 ctctcctgta tctcctcttg tgaccacacc gccctgatca tggcgtaaaa gaatacaaaa
      481 aaaggtaaaa tagggttcta tgggctgggc acagtggctc acgcctgtaa tcccagcact
      541 atgggaggcc gaggtgggca gatcacgagg tcaggagatc gagaccatcc tggctaacat
      601 agtgaaatcc cgtctctacc aaaaaataca aaaaattagc cgggcatggt ggcgggcgcc
      661 tgtcatccca gctattcggg aggctgaggc aggagaatgg tgtgaaccca ggaggtggag
      721 cttgcagtga gccgagattg cgccactgca ctccagcctg ggcaacagag tgagactctg
      781 tctcaaaaaa aaaaaaaaaa aaaattgggt tctatgatgg ataacaagag tactttccct
      841 agatagttgg aaaagacttg gctgaagaag taacacgtga cctggagcct gaatgatgag
      901 aaagaggcaa ctttaagaca acttgaaagt caagttttca gaacaaaagg gactccaagt
      961 acaagaagcc tgaggaagaa ccaagcttag agtgttcaag ggacagacag gaggccagtg
     1021 tggttgaagc aggggcacca ccattttacc tgtggtcacc agcatgcata aaatgtacaa
     1081 cacgaagact gaaccctagt gtgaggtgga ggggagcagg gcagaggggc cagattatag
     1141 gttctcaaag gccatggtaa gaattttata tttcattctg gttgtgatga gaaacttctg
     1201 acttcaagtt tgaagcaagg gagtgacatc atctatgtga tgctctagaa caactgctct
     1261 agttacaagg cgaaggatgg acaggagggc aggagaagga agcctgacag attctccaaa
     1321 aggacaaaaa gtcaacgtag ctgatgatca tgatgagggc agtcacgctt agggctggag
     1381 tcaaagggca gttttgggaa aattttggga aaatggcaga agtagaagtc ttgaatatcg
     1441 catcagaaat gtgatgctca tttttatttt tttcttttct tttagatgga gtcttgctct
     1501 gttgcccagg ctggagagca gtggcacgat gttggttcac tgcaacctcc gcctcccatg
     1561 ttcaagtgat tctcctgcct cagcctcctg agtagctggg attacaggtg tccaccacca
     1621 tgccctgcta atttttgtat ttttagtaga gacggggttt caccatgttg gtcaggctgg
     1681 tcttgaactc ctgacccgcc tcggcctccc aaagtgctgg aattgctcat ttttaatctc
     1741 agcagctcat tcacagatca tacatggaaa cttatcactc acacctaagc cttctttgcc
     1801 tgtcttagag atccctggtg caagaaactg taagattatt tgacacattt tctctgtctc
     1861 accctaacag cctctttcta gtatttgttt taaaaaactt attttttttt tttttgagaa
     1921 gttttttaga gcaagggttt ggggagacag agggatgaat aagtggagcc cagagggttt
     1981 ttagggcagt aaaactactc tacatgatac tgtaatggtg gatacatgtc accaccatgc
     2041 ataaaatgta caacaccaag actgaaccct agggtgaaat atggactcag gctgataatg
     2101 atgtgtcagt gtaggtttat cagttgtaac aaatgtacca ctttgaggct gggagcggtg
     2161 gctcatgcct gtaatcccag tactttggga gtccaaggtg ggcagatcac ctgaggtcag
     2221 gagttcaaga ccagcctggc caacattgtg aaacctcgtc tctactaaaa ctacaaaaat
     2281 tagctgggca tggtggcggg tgcctataat cccagctact tgggaggctg aggcaggaga
     2341 atcgcttgaa ccttggaggt tgaggttgcg gtgagctgag atggtgccac tgcactccag
     2401 cctggtccac agagcgagac tccatctcaa aaaaaaaaaa aagtaccact ttgggggtgg
     2461 tgttgataat gggggaggct gtacatgtgt aggggtagga ggcatgtagg aaatgtctgt
     2521 agctttccct cagttttgct gtaaatctta ctagtgtttg aatgccaaat ccttaagatc
     2581 atatctattt cttgtcactg gcagtgagtt ctgttcttga ctttccacta agagcagtac
     2641 tgatgacaac atcccgcagt attttatgag ccggagaaca ttaacatatc taaaagagta
     2701 cattttcctc tggagggcca ccagcctgta aactgcaggt caaaaagctg agtgtgaaca
     2761 gcattgttag gacatgtttc taagtgtatg ccaatatgtc cacagaggtt tttttagact
     2821 tataaagcga gctaaagaag acttttgttc cattttctga tttttaattt atatagacat
     2881 tttttcattt gaagaaagtg catatatttt taaaggaaag gtactcttaa gtctatccat
     2941 ttaagaaaat attaatctcc atggagaaga aattttccat attttaaaat ttattgtgtg
     3001 taggtatatt ccatatacac tctataaata aaaagcacac tggctgggcg cagtggctca
     3061 tatctataat cccaatgctt tgggaggctg aggcgggcag atcacctgag gtcaggagtt
     3121 tgagaccagc ctggccaaca ttgtgaaacc ctgtctctac taaagataca aaaattatct
     3181 gggtgtgatg gcagacgcct atagtcccag ctactcagga ggctgaggca ggagaatcac
     3241 ttgaacctag gaggtggagg ttgcagtgag ccaagatggc actactgcac tccagcctgg
     3301 gcaacagagc gacactccat ctcaaaaaaa taaataaata aataaaataa aaagcacaca
     3361 ctatcacaaa gaagatggtg gcaaaaataa taataaaaat agtaagtaaa taaatagcac
     3421 agaagtattt acagtaaaaa attaggtctc cttccagccc ccacctgcca atcactctca
     3481 ggaggcaccc actgtcttca gctacaaagc tttcagagag attttattaa tataagcaaa
     3541 tacatacttt ttaaaaaagt ataaataagg cctggtgcag tggctcacgt ctgtaattcc
     3601 agcactttgg gaggatgagg tggaaggatc tcttcaggcc aggagttaga gaccagcctg
     3661 ggcaacataa caagaccccc atctctaaaa aaacaatcaa aaaaactaac tgggcatggt
     3721 ggcatggttc tatagtccca gctactcagg aagctgagag tgagggattt cttgattcca
     3781 ggacttcgag gctgtcaccc actccagctt gggtgacaga gcaagactct gtctcaaaaa
     3841 aaaaaaaagt ataaacacta gcatatcata tattgccctg gacttttctt tttgatttaa
     3901 catatcttgg agattcttcc atagctgtgg ataaggagtt gcctcattct ttttcagggt
     3961 aagtttagta taaagggtga tatagtgggg aaattatatt taatttattt ttgccaactc
     4021 agtagcagag ctgtgacaag attaatcctt agatttttgg aggttcatat caaatcattc
     4081 aaagctttga catttttctc ttctttgtgg ctctattttc atcactaaaa ttccccatcc
     4141 tatgcccctg cagcccccat ctgacgtttg tcacttctct agcttagtca tctgatctaa
     4201 ttttgatgag tcagatgtaa ataaacccag ataatgtgtc ttttagccca aaagactaaa
     4261 agataaaata aaaggaaatg cataggacac agggcagttt gttgaatggc tgagatttga
     4321 atatgtgtgt attaattctt tctgaattac agctagattc tgccctcccc agctttgtat
     4381 ctggagacga gggaaaatgt gatcccagtt catattatga gtgaacatct ctgactgttc
     4441 taagaagtcc tattccctta gattactgaa gttcacaggg agaaagcacc cacccagata
     4501 tttttggttt ttgtttgttt gtttgtttgt tgagatggag tctcactcta ttgcccaggc
     4561 tagagtgcaa cggtatggtc ttggctcgct gaaacctttg cctcctggtt caagcgattc
     4621 tcctacctca acctcccaag tagctaagat ttcagacata agccaccatg cccagctaat
     4681 ttttgtgttt ttagtacaga cagggtttca ccacattgtt caggctgggc ttgaactcct
     4741 gacctcaggc gatccacccg cctcagcctc ccgaagtgct gggattacag gcatgagcca
     4801 ccgcacctgg cctcacccag atatttttca aataccattt tcgattccca ctctctttct
     4861 tgaagtaagc aaggcagaca catttgccaa ggataactga gaatgtaagg gcaatccatg
     4921 actgggcagc ttgtgcaggc tgtgtgctaa atgcactggg aaacatgccc tataaatagc
     4981 cgttcattgt cagcatgtgt gaaaagacaa gagagcattc cgtgctatga ttcaggccta
     5041 attaagtgat tgcgtctggg cacggctata aaccactagc tgcttcaact ggtaatccag
     5101 tcagtaggca actgcagggg ctcgccactg actgaaggca gtggaaggtt ggcagaagga
     5161 ggctgttcaa ggctgttttt gccttcacta tggcaaaaat cattttgagg cacctcatag
     5221 agattccagt gcgttaccag gaagagtttg aagctcgagg tctagaagac tgcaggctgg
     5281 atcatgcttt atatgcactg cctgggccaa ccatcgtgga cctgaggaaa accagggcag
     5341 cgcagtctcc tccagtggac tcagcggcag agacgccacc ccgagaaggc aaatcccact
     5401 ttcagatcct gctggacgtg gtccagttcc tccctgaaga catcatcatt cagaccttcg
     5461 aaggctggct gctgataaaa gcacaacacg gaaccagaat ggatgagcac ggttttatct
     5521 caagaagctt cacccgacag tacaaactac cagatggtgt ggaaatcaaa gatttgtctg
     5581 cagtcctctg tcatgatgga attttggtgg tggaagtaaa ggatccagtt gggactaagt
     5641 gacatcgtat cggttcctgt tcagatgaca tggggaagat gatggttcag ccactggtac
     5701 tacgagaatg tttgtattac ccacatttga aatgatttgc tatgattttt atgaagatta
     5761 aaaatatata cacagttcct ggtatgttga ggttgtcttt attattctta ctcagaaagg
     5821 aaaatttgta aatatgtttg tgtggctcaa actgatacta ttcttacaac tgaaacattg
     5881 aaaatacaga aggctgtatt tggatattag agaggactcc gaattgtttc ttattattcc
     5941 aacaatgcca gctgcatttg taatcactga tggcaaaaga gctataccca tttaaggaat
     6001 tcctatccat tttatgaaaa tcttttattt tgccaaaaag agttgtgatt cccttcactc
     6061 gataagcttt tctttttaat gtattttaat taaaatgagg ttttataaat atggagtgca
     6121 aaaattaaaa tacagtattt ggaaattggg tctgatatct atttatgatt tagtatagtt
     6181 gttactgcct taaaggtcaa tgggaatttt cagatataaa tcttattttt aaaaagttca
     6241 aatatgtacc tcattcatct ttttaaagat atactgaatc ctatctgaag tgttttgact
     6301 ttttaaagat agtataagtt ctatggacac gtacaaaatg ttcatgagat atgtatttac
     6361 atatcctctt gtaaattaat atgaagctta aggacaccac ttttaaaagt ttgattgctg
     6421 aattcagtga gttttaatct gtgcttttta gatgctccat aaacttagat ggcaaaatgt
     6481 aacacatctg ctatctctgc ataatcctta gctttaaata gcctggcagc caatggaagt
     6541 tcaacacctg agcttacact gcgtgtctga gtttacacag cacatctgat gattggtgct
     6601 tattatattc tcccaaacta ctgccttggc tcaaggtgga gacattggta gaggttaagg
     6661 actagtgcct tcaacagctg ctctgggaca ttccaaaggt ttgctatctc attctgtata
     6721 cattaagtat ttcttcagag gcagtggctg cctgcctttt accccgcact gaatgtgagc
     6781 tgacaagcag cccaaggaca gtgctaagaa tagacatgga atgcagggtg tggaaaacac
     6841 cagggcaaat gcagattgct gacagtatcc cagtactccc ccacgttgtt ttactgtagc
     6901 tcaagttaaa atgtaaaaga catgaagcaa tagaaaaacg aatcaaacag ttctaaaagt
     6961 tattttgaaa acaaatgtaa tctgagaaga atgtttactg tctaattaaa ttgaaaagat
     7021 tttgcagtta tatgcatatc tgaggtttat gcctatacat ggaggtttgt gtgtccaact
     7081 cagatatgaa aaattttgtt tgaccaagtg aatatcacag atcagcttgg ctgcataaca
     7141 aagttaatag cagtcgttga gattccagat ctactaatat gatcagaact gggataccat
     7201 ttgtctggat tatcattctt tcccagtgat tggcagaata gtgtgaaaag aaactaatgt
     7261 ggtgagaaac aaaaaaaccc tctctttcgg ccttgatctt actctagatg agatcctcct
     7321 cccgggaaaa ttcaggaggt gaaattccta ccatgaggag ccactgatag aaaatattct
     7381 ctttaaaaat aaaattaaag taaacacatg tctaatgagc tcttgttttt acaagataaa
     7441 ttttaaagtc ttatagataa gatatagata agttttaaag ataaatttta aagtcttata
     7501 gccatttttt tgatttggga aatataccaa acactataaa taataaaaat catctatggt
     7561 tcttctgcta ccatgaggca gctattttaa atatcttgtt caacaacagg actacataaa
     7621 tacatgtatc acttttcaca aaattaggat tatatctgta tggagtttga tatcctgatt
     7681 gtactggcta ctgtctgttg ccctccccac tcccaccaag tcaaaccatt ctctgccctt
     7741 ctcagcccca ctctgagccc aagcaggctg accctgatgg gcca
//

