LOCUS       NG_033731               9499 bp    DNA     linear   PRI 23-JUL-2013
DEFINITION  Homo sapiens GDP-mannose pyrophosphorylase B (GMPPB), RefSeqGene on
            chromosome 3.
ACCESSION   NG_033731
VERSION     NG_033731.1  GI:526120199
KEYWORDS    RefSeq; RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099668.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene is thought to encode a GDP-mannose
            pyrophosphorylase. The encoded protein catalyzes the conversion of
            mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in
            the production of N-linked oligosaccharides. Alternatively spliced
            transcript variants encoding distinct isoforms have been described.
            [provided by RefSeq, Jan 2009].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6368              AC099668.2         7299-13666
            6369-6369           "G"                1-1
            6370-9499           AC099668.2         13668-16797
FEATURES             Location/Qualifiers
     source          1..9499
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            <1..4680
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /note="inositol hexakisphosphate kinase 1"
                     /db_xref="GeneID:9807"
                     /db_xref="HGNC:18360"
                     /db_xref="MIM:606991"
     mRNA            join(<697..872,1320..4680)
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /product="inositol hexakisphosphate kinase 1, transcript
                     variant 1"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_153273.3"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_153273.3"
                     /db_xref="GI:58530860"
                     /db_xref="GeneID:9807"
                     /db_xref="HGNC:18360"
                     /db_xref="MIM:606991"
     mRNA            join(<697..872,1320..4680)
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /product="inositol hexakisphosphate kinase 1, transcript
                     variant 2"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_001006115.2"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_001006115.2"
                     /db_xref="GI:58530861"
                     /db_xref="GeneID:9807"
                     /db_xref="HGNC:18360"
                     /db_xref="MIM:606991"
     mRNA            join(<697..872,1320..4680)
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /product="inositol hexakisphosphate kinase 1, transcript
                     variant 3"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_001242829.1"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_001242829.1"
                     /db_xref="GI:338827647"
                     /db_xref="GeneID:9807"
                     /db_xref="HGNC:18360"
                     /db_xref="MIM:606991"
     CDS             join(<697..872,1320..1853)
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /EC_number="2.7.4.21"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_695005.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inositol hexaphosphate kinase 1; Pi uptake stimulator;
                     insP6 kinase 1; ATP:1D-myo-inositol-hexakisphosphate
                     phosphotransferase"
                     /codon_start=3
                     /product="inositol hexakisphosphate kinase 1 isoform 1"
                     /protein_id="NP_695005.1"
                     /db_xref="GI:23510335"
                     /db_xref="CCDS:CCDS33760.1"
                     /db_xref="GeneID:9807"
                     /db_xref="HGNC:18360"
                     /db_xref="MIM:606991"
                     /translation="MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDD
                     HTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETV
                     EQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHS
                     EVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFK
                     YPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCR
                     NKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSS
                     LLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPK
                     VDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ"
     CDS             join(<697..872,1320..1853)
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /EC_number="2.7.4.21"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_001229758.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 1 is encoded by transcript variant 3;
                     inositol hexaphosphate kinase 1; Pi uptake stimulator;
                     insP6 kinase 1; ATP:1D-myo-inositol-hexakisphosphate
                     phosphotransferase"
                     /codon_start=3
                     /product="inositol hexakisphosphate kinase 1 isoform 1"
                     /protein_id="NP_001229758.1"
                     /db_xref="GI:338827648"
                     /db_xref="CCDS:CCDS33760.1"
                     /db_xref="GeneID:9807"
                     /db_xref="HGNC:18360"
                     /db_xref="MIM:606991"
                     /translation="MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDD
                     HTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETV
                     EQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHS
                     EVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFK
                     YPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCR
                     NKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSS
                     LLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPK
                     VDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ"
     CDS             join(<697..872,1320..1853)
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /EC_number="2.7.4.21"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_001006115.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 2 is encoded by transcript variant 2;
                     inositol hexaphosphate kinase 1; Pi uptake stimulator;
                     insP6 kinase 1; ATP:1D-myo-inositol-hexakisphosphate
                     phosphotransferase"
                     /codon_start=3
                     /product="inositol hexakisphosphate kinase 1 isoform 2"
                     /protein_id="NP_001006115.1"
                     /db_xref="GI:55769518"
                     /db_xref="CCDS:CCDS43092.1"
                     /db_xref="GeneID:9807"
                     /db_xref="HGNC:18360"
                     /db_xref="MIM:606991"
                     /translation="MLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLL
                     LENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQ
                     LDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQ
                     ASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSP
                     EAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ
                     "
     gene            5001..7499
                     /gene="GMPPB"
                     /note="GDP-mannose pyrophosphorylase B"
                     /db_xref="GeneID:29925"
                     /db_xref="HGNC:22932"
                     /db_xref="MIM:615320"
     mRNA            join(5001..5377,5503..5583,5673..5721,5861..6003,
                     6221..6379,6465..6543,6617..6744,6828..7499)
                     /gene="GMPPB"
                     /product="GDP-mannose pyrophosphorylase B, transcript
                     variant 1"
                     /transcript_id="NM_013334.3"
                     /db_xref="GI:523567527"
                     /db_xref="GeneID:29925"
                     /db_xref="HGNC:22932"
                     /db_xref="MIM:615320"
     exon            5001..5377
                     /gene="GMPPB"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(5249..5377,5503..5583,5673..5721,5861..6003,
                     6221..6379,6465..6543,6617..6744,6828..7223)
                     /gene="GMPPB"
                     /EC_number="2.7.7.13"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_037466.2"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mannose-1-phosphate guanyltransferase beta;
                     GTP-mannose-1-phosphate guanylyltransferase beta"
                     /codon_start=1
                     /product="mannose-1-phosphate guanyltransferase beta
                     isoform 1"
                     /protein_id="NP_037466.2"
                     /db_xref="GI:11761619"
                     /db_xref="CCDS:CCDS2802.1"
                     /db_xref="GeneID:29925"
                     /db_xref="HGNC:22932"
                     /db_xref="MIM:615320"
                     /translation="MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAA
                     GVDHVILAVSYMSQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETAD
                     PFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFV
                     EKPQVFVSNKINAGMYILSPAVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMD
                     IGQPKDFLTGMCLFLQSLRQKQPERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGP
                     GVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVSLWAGLGGERGGECAC
                     LPDKAYPLLEVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM"
     exon            5503..5583
                     /gene="GMPPB"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            5673..5721
                     /gene="GMPPB"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     exon            5861..6003
                     /gene="GMPPB"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     exon            6221..6379
                     /gene="GMPPB"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     misc_difference 6369
                     /gene="GMPPB"
                     /note="This sequence differs from the reference genome
                     assembly (NCBI Build 37) at this position. A was replaced
                     by G to represent the standard allele identified by
                     alignment of public cDNAs."
                     /replace="a"
     exon            6465..6543
                     /gene="GMPPB"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     exon            6617..6744
                     /gene="GMPPB"
                     /inference="alignment:Splign:1.39.8"
                     /number=7
     exon            6828..7499
                     /gene="GMPPB"
                     /inference="alignment:Splign:1.39.8"
                     /number=8
     gene            complement(7446..>9499)
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /note="ring finger protein 123"
                     /db_xref="GeneID:63891"
                     /db_xref="HGNC:21148"
                     /db_xref="MIM:614472"
     mRNA            complement(join(7446..7790,7870..7955,8081..8175,
                     8322..>8464))
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /product="ring finger protein 123"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_022064.3"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_022064.3"
                     /db_xref="GI:375298724"
                     /db_xref="GeneID:63891"
                     /db_xref="HGNC:21148"
                     /db_xref="MIM:614472"
     CDS             complement(join(7670..7790,7870..7955,8081..8175,
                     8322..>8464))
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_071347.2"
                     /exception="annotated by transcript or proteomic data"
                     /note="kip1 ubiquitination-promoting complex protein 1"
                     /codon_start=2
                     /product="E3 ubiquitin-protein ligase RNF123"
                     /protein_id="NP_071347.2"
                     /db_xref="GI:37588869"
                     /db_xref="CCDS:CCDS33758.1"
                     /db_xref="GeneID:63891"
                     /db_xref="HGNC:21148"
                     /db_xref="MIM:614472"
                     /translation="MASKGAGMSFSRKSYRLTSDAEKSRVTGIVQEKLLNDYLNRIFS
                     SSEHAPPAATSRKPLNFQNLPEHLDQLLQVDNEEEESQGQVEGRLGPSTVVLDHTGGF
                     EGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQ
                     EEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSL
                     GTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYRPLQDPPSADLVRAQ
                     RLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHFAPLLRKVYLV
                     EAVLMSFLLGIVEKGTPTQAQSVVHQVLDLLWLFMEDYEVQDCLKQLMMSLLRLYRFS
                     PIVPDLGLQIHYLRLTIAILRHEKSRKFLLSNVLFDVLRSVVFFYIKSPLRVEEAGLQ
                     ELIPTTWWPHCSSREGKESTEMKEETAEERLRRRAYERGCQRLRKRIEVVEELQVQIL
                     KLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNMPMLCPPEYMVCFLHRLISALR
                     YYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKA
                     NIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALAVGGPLPLPRPGWLSSPTLGRAN
                     RFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDIEGSHWNEGLLLGRPPEEPEQ
                     PLTENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRK
                     DILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDRTG
                     SLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADARIV
                     GTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVR
                     LWRGCGFGYRYTRLPHLLKTKLEDANLPSLQKPCPSTLLQQHMADLLQQGPDVAPSFL
                     NSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMT
                     ITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHY
                     PILVAVTGILVQLLVRGPASEREQATSVLLADPCFQLRSICYLLGQPEPPAPGTALPA
                     PDRKRFSLQSYADYISADELAQVEQMLAHLTSASAQAAAASLPTSEEDLCPICYAHPI
                     SAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVEDWEKGANTSTTSSAA"
     gene            9170..>9499
                     /gene="AMIGO3"
                     /gene_synonym="AMIGO-3"
                     /note="adhesion molecule with Ig-like domain 3"
                     /db_xref="GeneID:386724"
                     /db_xref="HGNC:24075"
     mRNA            9170..>9499
                     /gene="AMIGO3"
                     /gene_synonym="AMIGO-3"
                     /product="adhesion molecule with Ig-like domain 3"
                     /transcript_id="NM_198722.2"
                     /db_xref="GI:224809459"
                     /db_xref="GeneID:386724"
                     /db_xref="HGNC:24075"
ORIGIN      
        1 ctaaaaaaaa aaaaaaaatt aggcatgcct gtagtcctag ttgttccaga ggctgagggt
       61 gagaggatct cttttcattt tgggaagatg aaaaagttct agctgggcgt ggtggctcac
      121 acctgtaatc ccagcacttt gggaggctga ggcaggcgaa tcacaaggtc aggagttcga
      181 gaccagcctg gccaacatgg tgaatccctg tctctactaa aaatacaaaa aatgagccgg
      241 gtgtagtggc gggcacctgt aatctcagct actcaggcag ccgaggcagg agaatagctt
      301 gaacctggga tgcagaggtt gcagttagcc gagatcactc cagggcactc cagcctgggt
      361 aacagagcga gactccgttt caaaaaaaaa gaaaagttct agagatagat ggttgtgagt
      421 agagatagat ggttgtgatg gttatacaac aaagtaaatg tacttcatgc cactgaattg
      481 tacacttaaa aatggctgaa gtaaatttta tgtatatttt accacagttt ttattggtta
      541 agtaataagc cagtggtgtg aaacccatat ttgagagttt gagacaagta catactgcat
      601 taggtaaaag ccccctttta tagaaaaact gggttgtgct ttcctggctg gggctgatgg
      661 tgagtgtggt tgtcattctc cttgaccgtg gcccagagtt cctcctgctt gagaacgtgg
      721 tgcaccactt caagtacccc tgcgtgttgg acctgaagat gggcacgcgg cagcatggcg
      781 atgacgcgtc agctgagaag gcagcccggc agatgcggaa atgcgagcag agcacatcag
      841 ccacgctggg cgtcagggtc tgcggcatgc aggtgagtta cctctgctca gagcctaggt
      901 gctgccactt gcatgatttg ggttgtgctc atacctgcct gccatctatg ccaagtgtgt
      961 cctcctgagc ccctctgtcc ttacctgttg actttgatat gggcctcagg tgcaggacca
     1021 ctgtgagagt ctgctgcctc gacattggga caaataagac tcttgcctgt caacaagatg
     1081 ttccgatgtt ggaggagggc tccaaagctg ggggcaggga acccataggc ctggtattgc
     1141 tttctcttgg ttctgcaatg ggaaaaccca gggtgaatgt ggcctgcctg gttccactta
     1201 gataggtgag cagaaaagct caggttggtc aaagtccctt ccagacagtg tttgcccagg
     1261 gcactgtgag ctcttcagac ttccctggca ctcaccctgt ctgcctcctg gggtttcagg
     1321 tgtaccagct ggacacaggg cattacctct gcaggaacaa gtactatggc cgtgggctct
     1381 ccattgaagg cttccgcaat gccctctatc aatatctgca caatggcctg gacctgcgac
     1441 gtgacctgtt tgagcctatc ctgagcaaac tgcggggcct gaaagctgtg ctggagcggc
     1501 aggcctctta ccgcttctac tccagttccc tgcttgtcat ctatgatggc aaggagtgcc
     1561 gggctgagtc ctgcctggac cgccggtctg agatgcgtct caagcacctg gacatggtgc
     1621 tccctgaggt ggcgtcatcc tgtggcccca gcaccagccc cagcaacacc agccccgagg
     1681 cgggtccctc ctctcagccc aaggtggatg tccgcatgat tgactttgca cacagcacat
     1741 tcaagggctt ccgggatgac cccaccgtgc atgatgggcc agacagaggc tacgtgtttg
     1801 gcctggagaa cctcatcagc atcatggaac agatgcggga cgagaaccag taggccctgt
     1861 tctgggcccc cagaacccct tcctctccac tgcaggcagg gaccattgtt ctgaacttgc
     1921 cgtgaggaca cacagacttg cttttaaagg gttatatttc tctttggtgt aaactaaaag
     1981 aaatgttttt agctgtagcc tggaatccat atatataaag tgaaggaggg cagaccacac
     2041 gccctctcag ccaggctcct cagctttgtg gctctgactg gtgtgtccag gctgccttag
     2101 gaaggaagag gtgcccctgg tgggcttggc agcagggaca gggtgccctt ggacattggt
     2161 ttctcttgtc tagatctttg agatctgtgg ctgcagggcc ctgctgattg taaggtaaag
     2221 ccctgggctg gtgcagggcc cctccacgcc cactcttccc ttgttcccca gaagtagagg
     2281 gctctgggtg cccatttctt gggggctttc cagtcttatg ctgtgggtgt cagctagctc
     2341 tttaataggt gccctcaggg caccacaggg ctgactgcac aaagctggac ccatccttcg
     2401 gtctgacctt agcatggggc tagattaatg aagctgggct gaggccaact tatggcagag
     2461 ggcggcgcct gggttcccca ggcacctgtt ggcacgtgac aggttggcac ctgtcctatt
     2521 cctgaaacag cctctctcac caagttccct tgcctaagaa ggccactccc tcccacccca
     2581 ctgaagtggg ggatagtcgg tgtcctagca ggcctcaggg cctctggtgg ctctggccca
     2641 gacagtattt gcagttcttg tgctatgggt gggagtcttc ttcctcaagt ttcggcagct
     2701 gtgctgctgc tggatgggct gctcctccca gggctcaagg gctgtggtcc gctcagggtc
     2761 tcatttcccc aggccaagtt caaggcagca gccctttgtg aggcgctctt ggccctgggc
     2821 ctggagggag aactttaagc ttttttgctc acagggacgt ggtatgggcc ctgggtgcag
     2881 gtgcccacat tctgctaatg agagctttgt ctgatcagtc ctgggtccat cagtttgtcc
     2941 atgtgtccgg ctgccagccc gtcccttggg atccttcccc tggggtgtag ccttgttcat
     3001 tagtatatac tcattccttc atgctttcct cagcagaaca cttccacttc tgaggtgagc
     3061 ttttgcccca tgcccttcct ccacaggtgt tgccttttta taaagacctg atagcagaat
     3121 aaattggtgt ttccctgttg acccagcacc atttctgtgg gcctagaata tggccctcaa
     3181 cccttagagt ggggcagtga gggcttgagg agtgaccctt cctttctcat ggttttagtc
     3241 attttggctg ccagccctta atggcacaga tctgctgctt ctaacagatg gccaggaggt
     3301 gacaccgatt tcagccattg ccaaggttag caccctctcc tttgagccta gggccacact
     3361 gttcattgtc actttaggca agtgcctgtt tggctttaaa ggtaagcctg ccagctgtga
     3421 gaagccttgg taactgatgg actcatttcc tggtccttaa agatgcagcc tcttaagggc
     3481 tccttgatgg atgccatctc tcctagcccc cagccctggt gccactggtg ggcaggttcc
     3541 cattctttgg ggctgggagg gacagcttgc ctgtttctgg tcacaaatta cagtcttctc
     3601 tcctgtacca ttctgtggct tcagccatgg gggcagtagc ccttcattag tgtagatagt
     3661 cattccctgg tagggtggag ggtaagacat agggtctgga actgtttggg accttttggg
     3721 gatgtcctgt gcctcccaga ttcctcgatt ctgggaggag aggctgccgc attctgctgc
     3781 tcctcacagc gagcaaagct gcacccactt acattcagta ttttcctggc actacaaaga
     3841 gtgggaaggc ctgggatttg ctgctgctcc cttagagcag ggcccctctt ttcagcactt
     3901 tggacacctg gagacccagc cctgttattt aatggtagtg ggcaagtgtg tgtgcatact
     3961 gtctgccact gctttctccc tgccccatgc cagagagccc tgtccctgcc aggcccagcc
     4021 ttcttagccc caacttggga acaaagtgca acatgggatc atgggttggg gtgctcaggt
     4081 gagccctctc tatagtgctt ccctgggcca agctgacacc agcccctgag ggtggggtgg
     4141 gacgggtggt gcttaaaaga ggaaggggac cagtgtagca acttgccagg gaccccaccc
     4201 ctccctctct gggcctgtgc agtgagcatg gggattccca tcaaggggcc tggcacctgt
     4261 gctagttacg tagccgctgc tcacgcgctc actcctgacc acatgcacgt tccctagatg
     4321 cagactgctt tgaactttaa agctgtacaa tttggttatg tttgtgctga cttaaaatat
     4381 attttaatga ggaaaaaata atggagaacc ctgggaagga cctggttctt ttgcttctcg
     4441 gggaactgta agccctcgcg ttctgggaat cgctctctgc tgctctttcc tggaagctaa
     4501 gcctgtctcc accgcccgag gcctgcgccg gtggctcccg ccgcagttgc gtttgctttg
     4561 gaccttgcgt gcgggggagg gggtgctcgg tccgagcccg ctcctttctg tacacctagc
     4621 gctgcccgcc ccgcttgtgt ctgaggtcgt gtatgtcaaa aataaagccg ctagaaacgg
     4681 aggcgagtct gtctttgtga aaatcccgtg gcccgggagc cttccctggt caccctcggg
     4741 gcgaggccgg ggccgtgggg cggggccggc ggctgctgga ccgcggcgaa gcagggaaca
     4801 aggcctcgcc cttggcgcca gttccgcctt tggatccgcc aatggccagc tgacccgcgg
     4861 gtcccggccc gggtctccat ggcagcccgg cgtactcggg cgctcattgg ctacgtctgt
     4921 cgcagcgctg cgctccaacg ttccgacgcc ggcggccgtg ccacgtacgc ggcagccgat
     4981 tggcccgcgg tggtcgcgtc actgcccgcg ccgggtccgg cctgagttcg gggccagcag
     5041 ccgtctaccc ggtgtcgcgt tctgtgttgt ggcggccctg gatccggcgt cagggcgacc
     5101 gggcggacga ggtggagcca gagtctgtca ggcgggttgg tgaagggcgc ggggccgggc
     5161 acggcgttgg gagtgcgcgg cagggaccgg ccaggcgggc tgcaggcacc tcagagcccg
     5221 ggacaccccc tcaacgtccg caggcgcgat gaaggcactg atcttagtgg ggggctatgg
     5281 gacgcggcta cggccgctga cgctgagcac cccgaagcca ctggtggact tctgcaataa
     5341 gcccatcttg ctgcaccaag tggaggcgct agccgcggta agaccctggg tcgggatcag
     5401 agtcgcgttc ggatctggcg ggactaggga tggccagcga ctaggggtca ggggctcccg
     5461 taccttctga ctgagcccgc ccgtcggcct gcgttctgac aggcaggcgt ggaccacgtg
     5521 atcctggccg tgagctacat gtcgcaggtg ctggagaagg aaatgaaggc acaggagcag
     5581 agggtgaggc acagactctt ggcccttatt ctcggtcccc gcccaacttc ccatcctggt
     5641 agaacctgac tgggggggcc tcttccttcc agctgggaat ccgaatctcc atgtcccatg
     5701 aagaggagcc tttggggaca ggtcagtaga ggcagaaagg tcccttgggg gagggtttaa
     5761 ggccaggaaa agggtaagac ccagcctgga gtgggcctgc tgagcctgaa tccagggact
     5821 cagacctcca gcaaggtggt gacctgtccc cttcccccag ctgggcccct ggcgctggcc
     5881 cgtgacctac tctctgagac tgcagaccct ttcttcgtcc tcaacagtga cgtgatctgc
     5941 gatttcccct tccaagccat ggtgcagttc caccggcacc atggccagga gggctccatc
     6001 ctggtaaggc gccaggtctt ctctctcttg acactttcac cctccatgcc cagcctccca
     6061 tgccccctag ccttcatctg ccttcggatg ttatggatac agagctgtgc agtatgtatc
     6121 tttaagcact tggggcagag tctcttgaga tctggaacgg catgtgtatc aaggcttagg
     6181 aacactggac taggtccgag gtccccttcc ttgcattcag gtgaccaagg tggaggaacc
     6241 ctccaagtac ggtgtggtgg tgtgtgaggc tgacacaggc cgcattcacc ggttcgtgga
     6301 gaagccacag gtgtttgtgt ccaataagat caacgcaggc atgtacatcc tgagccctgc
     6361 agtgctgcgg cgcatccagg tgtgtaggag acagctgttg gtgggctggg gtggggcagg
     6421 ccatcaccgc catgaccctg ctcacaagct gcccactccc acagctgcag cctacgtcca
     6481 ttgagaagga ggtcttcccc attatggcca aggaggggca gctatatgcc atggagttac
     6541 agggtgaggc agggaggcca cagggtgggg gtggtctgtg gctgggctga ggcccctgat
     6601 gcatccctcc ctacaggctt ctggatggac attgggcagc ccaaggactt cctcactggc
     6661 atgtgcctct tcctgcagtc actgaggcag aagcagcctg agcggctgtg ctcaggccct
     6721 ggcattgtgg gcaacgtgct ggtggtgagg cccttgccca gcccatcatt aaccccctca
     6781 gtcttgggag acaagtggcc cacttgtatt tttcccaccg ctctcaggac ccaagtgccc
     6841 gcatcggcca gaactgcagc attggcccca atgtgagcct gggacctggc gtggtggtcg
     6901 aagatggtgt gtgtatccgg cggtgcacgg tgctgcggga tgcccggatc cgttcccatt
     6961 cctggcttga gtcctgcatt gtgggctggc gctgccgcgt gggtcagtgg gtaagcctgt
     7021 gggctgggct gggtggggag aggggcgggg agtgtgcctg cctccctgac aaggcctatc
     7081 ctctcctgga ggtacgcatg gagaacgtga cagtgctggg tgaggacgtc atagttaatg
     7141 atgagctcta cctcaacgga gccagcgtgc tgccccacaa gtctattggc gagtcagtgc
     7201 cagagcctcg tatcatcatg tgaggggatg cagtggggct ggccgagccc cggttttccc
     7261 atcagcaagg ggagtgctgg cctgacacat cagaagaccc tggacttgtc attatttgtc
     7321 tggggggcac tgggtgaagc tgaagctgtt ggacacctgc cttctcatgt ggacatcatc
     7381 tggcaggatc cctgctgggc acaccccaca aaccccactc cctcaagaag ggccagggcc
     7441 agggctgtat ggaataataa tttaatgctc actgtggccc tgactgaaag tcaagctcag
     7501 gcacaattag ggccatggct gggctcccac caatgaggat acaggcaggc aaggaggttg
     7561 gatgtggtgg tgtgggatac aggagaaggg caaagggagc tcataaatag ggcccagcct
     7621 ggctctgggt tcaaaggtgg aggttccagg atggcacagg ctgtgagggc taggcagctg
     7681 aggaggtagt actcgtattg gctcccttct cccagtcctc tacagacacg atggtggttt
     7741 tgcagaagaa gcagtccttg ttgttcatca ggtgctggtt gatacaggct ctacaacagg
     7801 ggaggggatg aggactgccc tgcatgtacc tactgctctc cccaccacca agctgtgggg
     7861 cccacttact tgcaggactt gtggccacag ggctggaaca cagcagagat ggggtgggca
     7921 tagcagatgg ggcagaggtc ctcctcactg gtgggctgca gggaggagag tgaagggtgg
     7981 gctggagttg gatgcctggc tatgtggatg tccgttgtgc ctgtgtagga gtgcacacat
     8041 attcaagtgg catggacctg tgcaccgtgt tcccactcac cagggaggca gctgctgcct
     8101 gggcagatgc agaggtcagg tgcgccagca tctgttccac ttgggccagc tcatcggcac
     8161 tgatataatc cgcatctggg gagtggtagg tagtgtcaag tcagaggtag ctgaggatgt
     8221 gatgcctctt gaatattccc agcctaggac tttgctgttc ttaaggctcc tgacccgacc
     8281 cagccccaga tttccctgac ctgccccacc agcccactca cagctctgca gggagaagcg
     8341 cttccggtca ggggctggca gagcagtgcc aggtgctggg ggctctggct gtcccaggag
     8401 atagcatatt gagcgtagct ggaagcaggg atctgccagg agcactgatg tggcttgctc
     8461 tctcctaggt aggggagggt gcaagggcag tcagaaggct tggggcctgg ctaaaagtct
     8521 ctcttgggat tgccaatgag gagtgccatg gctcgtacat gatcaccccc cctgcatcct
     8581 ttccgtctcc ctgcttccca aaccccaagt cctgtattct agtaaggtgc cacacagcct
     8641 gttttttttt tttttttctt gagacgagtc tcgctctgtt gcccaggctg gagtgcgatg
     8701 gcacgatctc ggctcactgc aacctccacc tcccgggttc aagtgattct cctgctttag
     8761 cctcccgagt agctggaatt gcagacgccc accaccacgc ccggctaatt gttgtatttt
     8821 tagtagagac agggtttcac caggttggcc aggctggtct cgaattcctg acctcaggtg
     8881 atccacctgc cttggcttcc caaagtgctg ggattacagg cgtgagccac cgcgcccggc
     8941 ctggggtacc actttaagaa ggctcaggcg aaccacctta agatagtgag agtctgcctg
     9001 ccccataata ttatcagtcc ttcaaagtca cttcaaataa acactaacag cagcttggag
     9061 acattcttcc agactccccc ttttactccc cgaggaaaaa cgagcggcgg agagctgcca
     9121 gccaaaggct gacggggact ttggggttgg ccttgctccc catctggcgg tcatgcgggg
     9181 ccattgggca caaagggatg tagccgcccc gcctcctcaa acgggaacca ataggagccc
     9241 gggccccgcc cctgggggga gtatttagga gccgatcagg aactcgcttg gagagggcta
     9301 gcgaagccga agggagcgcg gctaagagtg ccgcaccgcc tcacaacctg ggaaccggag
     9361 agtaggggcc gtcggctggc aagaacccgc cgtgcctcct cggcaagggc catccggtgc
     9421 cacccatgtc gcactagagc agaagagggt gagtcctgga actgcaacct gcacagagct
     9481 gctctgtact gtccctggt
//

