LOCUS       NG_012871               7630 bp    DNA     linear   PRI 05-MAR-2010
DEFINITION  Homo sapiens dolichyl-phosphate mannosyltransferase polypeptide 3
            (DPM3) on chromosome 1.
ACCESSION   NG_012871
VERSION     NG_012871.1  GI:257743455
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL607067.17 and AL691442.32.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor
            of mannosyl residues on the lumenal side of the endoplasmic
            reticulum (ER). Lack of Dol-P-Man results in defective surface
            expression of GPI-anchored proteins. Dol-P-Man is synthesized from
            GDP-mannose and dolichol-phosphate on the cytosolic side of the ER
            by the enzyme dolichyl-phosphate mannosyltransferase. The protein
            encoded by this gene is a subunit of dolichyl-phosphate
            mannosyltransferase and acts as a stabilizer subunit of the
            dolichyl-phosphate mannosyltransferase complex. [provided by
            RefSeq].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1697              AL607067.17        2001-3697           c
            1698-7630           AL691442.32        86163-92095         c
FEATURES             Location/Qualifiers
     source          1..7630
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            5001..5630
                     /gene="DPM3"
                     /gene_synonym="CDG1O; MGC125904; MGC125905; MGC34275"
                     /note="dolichyl-phosphate mannosyltransferase polypeptide
                     3"
                     /db_xref="GeneID:54344"
                     /db_xref="HGNC:3007"
                     /db_xref="MIM:605951"
     mRNA            join(5001..5030,5276..5630)
                     /gene="DPM3"
                     /gene_synonym="CDG1O; MGC125904; MGC125905; MGC34275"
                     /product="dolichyl-phosphate mannosyltransferase
                     polypeptide 3"
                     /transcript_id="NM_153741.1"
                     /db_xref="GI:24430134"
                     /db_xref="GeneID:54344"
                     /db_xref="HGNC:3007"
                     /db_xref="MIM:605951"
     exon            5001..5030
                     /gene="DPM3"
                     /gene_synonym="CDG1O; MGC125904; MGC125905; MGC34275"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     exon            5114..5630
                     /gene="DPM3"
                     /gene_synonym="CDG1O; MGC125904; MGC125905; MGC34275"
                     /inference="alignment:Splign:1.39.8"
                     /number=2a
     STS             5141..5617
                     /gene="DPM3"
                     /gene_synonym="CDG1O; MGC125904; MGC125905; MGC34275"
                     /db_xref="UniSTS:489903"
     exon            5276..5630
                     /gene="DPM3"
                     /gene_synonym="CDG1O; MGC125904; MGC125905; MGC34275"
                     /inference="alignment:Splign:1.39.8"
                     /number=2b
     CDS             5281..5559
                     /gene="DPM3"
                     /gene_synonym="CDG1O; MGC125904; MGC125905; MGC34275"
                     /EC_number="2.4.1.83"
                     /note="isoform 2 is encoded by transcript variant 2;
                     prostin 1; dolichol-phosphate mannose synthase subunit 3;
                     dolichyl-phosphate beta-D-mannosyltransferase subunit 3;
                     mannose-P-dolichol synthase subunit 3; prostin-1; MPD
                     synthase subunit 3; DPM synthase complex subunit 3;
                     dolichol-phosphate mannosyltransferase subunit 3"
                     /codon_start=1
                     /product="dolichol-phosphate mannosyltransferase subunit 3
                     isoform 2"
                     /protein_id="NP_714963.1"
                     /db_xref="GI:24430135"
                     /db_xref="CCDS:CCDS1095.1"
                     /db_xref="GeneID:54344"
                     /db_xref="HGNC:3007"
                     /db_xref="MIM:605951"
     STS             5467..5621
                     /gene="DPM3"
                     /gene_synonym="CDG1O; MGC125904; MGC125905; MGC34275"
                     /standard_name="A008V48"
                     /db_xref="UniSTS:1136"
     gene            complement(6663..>7630)
                     /gene="RAG1AP1"
                     /gene_synonym="RP11-540D14.5; SCP; slv"
                     /note="recombination activating gene 1 activating protein
                     1"
                     /db_xref="GeneID:55974"
                     /db_xref="HGNC:30657"
     mRNA            complement(join(6663..7341,7423..>7542))
                     /gene="RAG1AP1"
                     /gene_synonym="RP11-540D14.5; SCP; slv"
                     /product="recombination activating gene 1 activating
                     protein 1"
                     /transcript_id="NM_018845.3"
                     /db_xref="GI:170932468"
                     /db_xref="GeneID:55974"
                     /db_xref="HGNC:30657"
     mRNA            complement(join(6663..7341,7423..>7542))
                     /gene="RAG1AP1"
                     /gene_synonym="RP11-540D14.5; SCP; slv"
                     /product="recombination activating gene 1 activating
                     protein 1"
                     /transcript_id="NM_001122837.1"
                     /db_xref="GI:170932478"
                     /db_xref="GeneID:55974"
                     /db_xref="HGNC:30657"
     mRNA            complement(join(6663..7341,7423..>7542))
                     /gene="RAG1AP1"
                     /gene_synonym="RP11-540D14.5; SCP; slv"
                     /product="recombination activating gene 1 activating
                     protein 1"
                     /transcript_id="NM_001122839.1"
                     /db_xref="GI:170932484"
                     /db_xref="GeneID:55974"
                     /db_xref="HGNC:30657"
     CDS             complement(join(7240..7341,7423..>7542))
                     /gene="RAG1AP1"
                     /gene_synonym="RP11-540D14.5; SCP; slv"
                     /note="isoform a is encoded by transcript variant 1;
                     RZPDo834D038D; stromal cell protein; RAG1-activating
                     protein 1"
                     /codon_start=1
                     /product="RAG1-activating protein 1 isoform a"
                     /protein_id="NP_061333.2"
                     /db_xref="GI:170932469"
                     /db_xref="CCDS:CCDS1093.1"
                     /db_xref="GeneID:55974"
                     /db_xref="HGNC:30657"
     CDS             complement(join(7240..7341,7423..>7542))
                     /gene="RAG1AP1"
                     /gene_synonym="RP11-540D14.5; SCP; slv"
                     /note="isoform b is encoded by transcript variant 2;
                     RZPDo834D038D; stromal cell protein; RAG1-activating
                     protein 1"
                     /codon_start=1
                     /product="RAG1-activating protein 1 isoform b"
                     /protein_id="NP_001116309.1"
                     /db_xref="GI:170932479"
                     /db_xref="CCDS:CCDS44239.1"
                     /db_xref="GeneID:55974"
                     /db_xref="HGNC:30657"
     CDS             complement(join(7240..7341,7423..>7542))
                     /gene="RAG1AP1"
                     /gene_synonym="RP11-540D14.5; SCP; slv"
                     /note="isoform c is encoded by transcript variant 3;
                     RZPDo834D038D; stromal cell protein; RAG1-activating
                     protein 1"
                     /codon_start=1
                     /product="RAG1-activating protein 1 isoform c"
                     /protein_id="NP_001116311.1"
                     /db_xref="GI:170932485"
                     /db_xref="CCDS:CCDS44238.1"
                     /db_xref="GeneID:55974"
                     /db_xref="HGNC:30657"
ORIGIN      
        1 atggaatctc actctgttgc ccaggctgga gtccagtggc atgatctcgg ctcactgcaa
       61 cctccacctc ccgggttcaa gcaattctcc tgcctcagcc tcccgagtag ctgggattat
      121 aggcatctgc caccacccct ggctaatttt gtattttcag tggagacctg gttttaccat
      181 gttggccagg ctggtctcca actcctgacc tcaagtgatc cacacacctc ggcctcccaa
      241 agtgctggca ttacaggcgt gagccaccgc gcccggccag tagtacttat ttcgcatggt
      301 tgctgtgaag attgactgag ataatgcaca taaagcactc atcacagtgc ctgacacata
      361 ggaatcatag tgacatagag ctgacacata gtgaatgtca gctgttgtga tgaaccctaa
      421 ctgcccattc ctgtagcagc aacacagtag aatgaaagtg ctaagaatat agttttgggt
      481 ccaatgaaac agctttgctg tttactatct gcacaacctt gagctagtta cttacctttt
      541 gccctctctg tgtcatggtt tcctcattca tacatgggaa tagaaaagta cctacttcat
      601 tcggctgggt gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg
      661 aattgcctga ggtcaggagt ttgagaccag cctggccaga gtggtgaaac cccatctcta
      721 ttaaaaatac aaaaattagc tgagcatggt ggcaggtgcc tataatccca gctactcggg
      781 aaactgaggc aggagaatcg cttgaacccg ggaggcagag gttgcagcga gctgagattg
      841 taccactgca ctccagcctg ggcgacagag caaggctctg tctcaaaaaa aaaaacaaaa
      901 cccaaaaaac agaaatactt tataatttat tatctatcct tatatgtggt ggtgtaagcc
      961 cctaaaatgt tctggggagt ttcagggcca agtctactgt gtatgaataa aatggacttt
     1021 ctggatctgc atctgcaatg ctcgtgtcca gcccctgtaa gtataccaat atttgaaagt
     1081 cattgtgacc agtgagtcct tgattgagaa accagaaaga tttggtgtgg aaatggaaat
     1141 gtggctaggg ctttgaaggt cgtatagcag gtttaaaaac attttttttt ttttgagaca
     1201 gagtctcgct ctgtcaccca ggctggagtg cagtggcaca gtctcggctc actgcaacct
     1261 ccgcctcccg ggttcatgcc attctcctgc ctcagcctcc caagtagctg ggactacagg
     1321 cacccgccac cacgcccggc taattttttt tttttttttg tatttttagt ggagacgggg
     1381 tttcaccgtg ttagccagga tgatctcgat ctcctgacct cgtgatccac ccgtctccac
     1441 ctcccaaagt gctgggatta caggcgtgag ccaccgcacc cagcctaaaa aatgtttttc
     1501 gctaggagcg gtggctcacg cctgtaatcc cagcactttg ggaggccgag ggggcgaatc
     1561 acctgaggtc tggagtttga gaccagcccg gccaacaagg tgaaacccca actctactaa
     1621 aaatacaaaa attagccagg catggtggca ggtgcctgta atcccagcta ctcgggaggc
     1681 tgaggcagga gaattgcttg aacccgggag gcggaggttg cagtgagcca agaccgtgtc
     1741 atttcacccc aacctcggcg acaagagcaa aactccggct caaaaaaaaa aaaaaaaaaa
     1801 gtttgggctg agcgcggtgg ctcacgcctg taatcccagc actttgggag tccgaggtgg
     1861 gaggatcaca agctcaggag ttcgagacca gcctgaccaa catggtgaaa ccctgtcttt
     1921 aataaaaata caaagatttg ctgggtgtgg tggtgcgtgc ctgtagtccc agctacttgg
     1981 gatgttgagg caggctaatc gcttgaacat gggaggcaga ggttgcagtg agctgagatc
     2041 atgccactgt actctagcct gggccacaga acgagactct gtctcaaaaa aaaaaagaaa
     2101 agtttttatt tgttttaatt tttactttaa caaaggaatt tgtatagttt taaaagccaa
     2161 ctagttcaac aaatattttt cggggtggcg gggcattttc aagtgaaaac cgggaaacct
     2221 gctcaacaaa ttctgaaagc tgtaacttcg gtgggcgccg tggcttacga ctgcaatagc
     2281 agcactttgt gggggctgag atgaattgct tgagcccagg attttgagac cagcctgggc
     2341 aacataggga gaccccgtct acacacacac acacacacac acacacacac acacacacac
     2401 acacactaga tgggcgtggt ggtggtggcc cacttctgta gtccctgcta ctccagagtc
     2461 tgaggtggga ggatagcttg agtccaggag gtcgaggctg cagtaagcca tgtttgcacc
     2521 gctgctctcc accctgggca acagagcaag accttgtctg aaaaaaagaa aaagaataga
     2581 aaaaaaaaga gctgtaactc tacaaggctt ttaatgaaaa ataaccatcc cctgctcctc
     2641 ttctttaacc cttacatata caacctacat atacaactac gctccagttt ctaggctgct
     2701 tcttctggta cttatctgta catttcttca agcaacactc ccacctaggc ctcccaaagt
     2761 tctgggatca cagctccact gtccccagct ccaattttta gttaaatcaa tacttagtgt
     2821 ttacatcgtt acggctgtga aaattttctt cacagctgag ccatttgtgt ttgtgctaag
     2881 actgtgaatc tgtaaaaact gcttttgtta attaacatcc aggacatacg gctgagaaac
     2941 ttcattttct aaaatcatag tcacaaactt tgctatttga aatcagtcag tgcgaatgga
     3001 acatcctact cttgccagaa gttctgagcc acgtggatta ctttggcctc ccaaagtgtt
     3061 gggattacag gcacgagcca ctgtgcccag cctagatagt gggtttttgg acactatatt
     3121 ctatatttat cttgactttg taatttccaa gtggtccctc agcttggact tcttgatccc
     3181 ttcacttaaa gttatgctta cctcgaaccg atcaaaacac tgtttcattt aaattttagc
     3241 tagcctatag tatcagccac ttgggaggct gaggcaggag gatcacttga gcccagaagt
     3301 ttgagcttcg cctgggcaac ataccgagac ttcaactcta aataaataag taaataaatt
     3361 ttaaaatata aattttaaag tcaagccttt cccatatcct gttgtattag ttcattttca
     3421 cattactgat aaagacatac ccgaaactgc aaacaaaaag aggtttaatt ggacttacag
     3481 ttccacattg ctggggaggc ctcagaatca tggcgggaga caaaggcact tcttacatgg
     3541 cggtggcaag agaaaaatga ggaagaagca aaagcagaaa cccctgatga actcatcaga
     3601 tcttgtgaga cttattcact atcatgaaaa tagcacggga aagtctggcc cccgtgattc
     3661 aattacctcc ccttaggtcc ctcgcacgtg ggaattctgg gagatacaca tcaacttgaa
     3721 atttgggtgg ggacacagcc aaaccatatc atctgaatga ccatatttct tcctttttaa
     3781 tgagttgccc cacagttctt ctagtgtgtg atctctctgt tgtggcaagt taataaacct
     3841 aactgtcaaa ctacagatgt ggtctttata agacaggctt atcaattgtc tttcctttct
     3901 tatataactc tttgtttcct ctgaagttga taattgccta accttttctc ttactttgtt
     3961 ctctctctct ctttctctct atacataata aattcatccc caaaactgtt ctaaagaatt
     4021 atactctttc tttcaatgcc ttcaccactt caggtaattc ttctggtctt tcttttcttt
     4081 tctttttttt tgaaacccag actcctggag cccttcttcc tctggctcca agttatattg
     4141 gttgttgtcc ttgtaaaaat atgactacct ctgttctaac aataatctca agccttcatg
     4201 gttagttgtc aatgcaactg cttcactgac tcctgctttc cccctccacc tgaaaggggt
     4261 cgagtctctt gacatctctg tatctccaaa gtctatcatg gtaatcaaga aatgttctgg
     4321 ccgggcgctg tggctcatgc ctgtaatcct agcactttgg aaggctgagg tgggccagtc
     4381 acttgaggtc aggagtttga gaccagcctg gccaacatag tgaaatcccc gttctctgct
     4441 aaaaataaaa aaattagccc ggcgtggtgg cgcgcgcctg taatcccagc tgctcgggag
     4501 acagaggttg cagtgagctg agatcgagcc actgtactcc agcatgggca acagagcgag
     4561 actttgtctc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaggagttct gtcccgccta
     4621 ggcactatag agagaccctg tcaagaatgg aaagaaagaa atcttcgaat gaatgaacta
     4681 gtgaatgaag gaatggattt cagcgctgga gaattgagtt taaggggaat ggtattatat
     4741 tcccatcttg ttgcaacatt taaggatgtc ctcaagcccc acgccagcct ggagcgtagc
     4801 ccaaggtggg aaagcagcgc cgaggcctct ccagacccgg cctgctcccc gtttgcggag
     4861 cacagcccac tgtacccccg cctagattga ggcgctggcc aggagtacac caggcgccgc
     4921 catgtgaact acaactccca gaaggccgcg cggaagcgga acgtgaacca gggaggactt
     4981 ccggacgcca acatccgggc cgcgcgggga aggggagacg tggggtagag gtaagtgtag
     5041 gttgaaggct gaatggggag ggcgagagat ggggagtggg tctcaaatat agagggggta
     5101 gcaaggtgga aggggccctt ccaccttttg tgggcactca agttcggacc tctgggatcg
     5161 gcgattcccc tctggccagg gctggtttta atgctctccg tgggcgggct tcggttgagt
     5221 ttggtccgct tttcctttct gctcctcagg ggagcattgc ttccttctct cgcagtgacc
     5281 atgacgaaat tagcgcagtg gctttgggga ctagcgatcc tgggctccac ctgggtggcc
     5341 ctgaccacgg gagccttggg cctggagctg cccttgtcct gccaggaagt cctgtggcca
     5401 ctgcccgcct acttgctggt gtccgccggc tgctatgccc tgggcactgt gggctatcgt
     5461 gtggccactt ttcatgactg cgaggacgcc gcacgcgagc tgcagagcca gatacaggag
     5521 gcccgagccg acttagcccg cagggggctg cgcttctgac agcctaaccc cattcctgtg
     5581 cggacagccc ttcctcccat ttcccattaa agagccagtt tattttctaa cttcgtttag
     5641 tttgagtatg gaaaacgggt attggggatt ctatgtacta acggtcgaga agtgaatgtg
     5701 aaagaaccac cttcttgagg ccatctcagc ctttatcttt gcatcttgct ggtgttccca
     5761 tttttgctcc caaggaggca aagacccctt ctcaatattt ctcaggatgg aaatgacatt
     5821 tcactttcct ggtcctttca accctgtagg aagtacttct tttttttttt ttttgagacg
     5881 gagccttgct ctgtcgtcca ggctggagtg cagtggcgtg atctcggctc actgcaagct
     5941 ccgcctcccg ggttcacgcc attctcctgc ctcagcctcc tgagtagctg ggactacagg
     6001 cgcctgccac cacgcctggc taattttttg tatttttagt agagtcgggg tttcaccgtg
     6061 ttggccagga tggtctgatc tcctgacctc gtaatccgcc cgcctcggcc tcccaaagtg
     6121 ctgggattac aggtgtgagt caccgcgccc ggcgtactac ttcttttttt tttttttttt
     6181 gagacagggt ctcactctgt tgcccaggct ggagtgcagt ggtgcaatca tggctcactg
     6241 cagcctcacc ctcccaggct caaacagttc tcccacctca gcctccagag tagctgggac
     6301 tacaggcata tgccaccacg ccaccaggct aatgtttaat tttttgtagt gacagggtct
     6361 cgctgtgttg ctcaggctgt tctcaaactc ctgggctcaa gtgatcctcc tgcctgggcc
     6421 tcccaaagtg ctgtgattac agacataagc caccttaccc ggccagaagt actttcttga
     6481 agcctaagtt ccattcttca taacatccaa gttttgttat ttttaaggcc ttcctgggtc
     6541 tttccaacct tttggttctt tgagatacct tttctgagcc taccctacca acctgagaat
     6601 aactgtggat ctatccttca ccaaaccagg caggtttaga attatgagta gagaatgaac
     6661 catcgtgggc aggggtgggg aacactttat tttaaggcat attcatatca gcatataagg
     6721 catattcata tcacaatggc acgatctcag ctcactgcaa cctccacctc ctgggttcaa
     6781 gcaattctcc tgcctcagcc tcccaagtat ctgggattac aggcatgtgc catcatgcct
     6841 ggctaatttt gtatttttag tagagatggg gtttcaccat gttagtcagg ttggtcttga
     6901 actcctgacc tcaggcgatc cgcccacctt ggcctcccaa agtgctggga ttacaggcgt
     6961 gagccaccgc gcccggcctt ttaaggcata ttctaaagat tgcaccccaa cctccaaaat
     7021 taaaaaaaaa aatctctaaa aaataaaaag tgatttcatc tcctaggccc caatcaatca
     7081 tctaagtaaa gctttttctt tggtcctttt atcctcaaag tcatctcttg ttcccacaac
     7141 ccactgcacc tgggaagctg gacagcaggc ccagctgaaa caaggaggtc tctttggttc
     7201 aggttggcac taaggtgccc agtggtcaga tgagcagcct caggtttgca ggagccagta
     7261 gttcctgtct tgctcctggg ggtacttcca gaaaagccag aagcggataa agctggtgac
     7321 gattcctgga aagttggaca cctgaaatca caagaactgc tatgaggaga ggagccagtt
     7381 ttccatcttg cacccctgtc accccatccc agttgtgctt accatgatat agggatctct
     7441 gagtcgaaac ccatagaggc accaggaggc agaggtgaga agggtagcaa tggtgagtgg
     7501 gtaggagaga cattgggttg atttagtttg aatcacctta gcctgtggga aagaatggaa
     7561 gactctcttg gcccaagcac atcgtaaagc ttcacttgcc taagaatttc ctcaagaaaa
     7621 aggtcagaca
//

