LOCUS NG_008043 15363 bp DNA linear PRI 01-MAR-2010 DEFINITION Homo sapiens desmin (DES) on chromosome 2. ACCESSION NG_008043 VERSION NG_008043.1 GI:190358508 KEYWORDS RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Johan den Dunnen. The reference sequence was derived from AC053503.7. This sequence is a reference standard in the RefSeqGene project. Summary: This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-15363 AC053503.7 71181-86543 FEATURES Location/Qualifiers source 1..15363 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="2" /map="2q35" STS 70..328 /standard_name="REN52731" /db_xref="UniSTS:377531" STS 300..550 /standard_name="REN52732" /db_xref="UniSTS:377532" STS 390..619 /standard_name="REN52733" /db_xref="UniSTS:377533" STS 596..847 /standard_name="REN52734" /db_xref="UniSTS:377534" STS 839..1086 /standard_name="REN52735" /db_xref="UniSTS:377535" STS 1068..1311 /standard_name="REN52736" /db_xref="UniSTS:377536" STS 1293..1520 /standard_name="REN52737" /db_xref="UniSTS:377537" STS 1416..1657 /standard_name="REN52738" /db_xref="UniSTS:377538" STS 1627..1873 /standard_name="REN52739" /db_xref="UniSTS:377539" STS 1813..2073 /standard_name="REN52740" /db_xref="UniSTS:377540" STS 1905..2181 /standard_name="ECD20657" /db_xref="UniSTS:301656" STS 1962..3001 /standard_name="stSG632972" /db_xref="UniSTS:460340" STS 2026..2284 /standard_name="REN52741" /db_xref="UniSTS:377541" STS 2260..2516 /standard_name="REN52742" /db_xref="UniSTS:377542" STS 2489..2739 /standard_name="REN52743" /db_xref="UniSTS:377543" STS 2672..2854 /standard_name="ECD23636" /db_xref="UniSTS:304620" STS 2716..2981 /standard_name="REN52744" /db_xref="UniSTS:377544" STS 2973..3226 /standard_name="REN52745" /db_xref="UniSTS:377545" STS 2991..3360 /standard_name="ECD18191" /db_xref="UniSTS:299202" STS 3091..4332 /standard_name="stSG632973" /db_xref="UniSTS:460341" STS 3208..3452 /standard_name="REN52746" /db_xref="UniSTS:377546" STS 3433..3687 /standard_name="REN52747" /db_xref="UniSTS:377547" STS 3648..3872 /standard_name="REN52748" /db_xref="UniSTS:377548" STS 3686..4324 /standard_name="ECD09041" /db_xref="UniSTS:290087" STS 3839..4094 /standard_name="REN52749" /db_xref="UniSTS:377549" STS 4071..4337 /standard_name="REN52750" /db_xref="UniSTS:377550" STS 4312..4568 /standard_name="REN52751" /db_xref="UniSTS:377551" STS 4357..4990 /standard_name="ECD09257" /db_xref="UniSTS:290301" STS 4488..4753 /standard_name="REN52752" /db_xref="UniSTS:377552" STS 4730..4984 /standard_name="REN52753" /db_xref="UniSTS:377553" STS 4960..5229 /standard_name="REN52754" /db_xref="UniSTS:377554" gene 5001..13363 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /note="desmin" /db_xref="GeneID:1674" /db_xref="HGNC:2770" /db_xref="MIM:125660" mRNA join(5001..5664,6719..6779,6875..6970,7119..7280, 7452..7577,7964..8184,10401..10444,12287..12369, 12573..13363) /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /product="desmin" /transcript_id="NM_001927.3" /db_xref="GI:55749931" /db_xref="GeneID:1674" /db_xref="HGNC:2770" /db_xref="MIM:125660" exon 5001..5664 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /inference="alignment:Splign:1.39.8" /number=1 CDS join(5087..5664,6719..6779,6875..6970,7119..7280, 7452..7577,7964..8184,10401..10444,12287..12369, 12573..12614) /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /note="intermediate filament protein" /codon_start=1 /product="desmin" /protein_id="NP_001918.3" /db_xref="GI:55749932" /db_xref="CCDS:CCDS33383.1" /db_xref="GeneID:1674" /db_xref="HGNC:2770" /db_xref="MIM:125660" STS 5087..5467 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="PMC209322P1" /db_xref="UniSTS:271986" STS 5209..5469 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52755" /db_xref="UniSTS:377555" STS 5210..5701 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="ECD14535" /db_xref="UniSTS:295555" STS 5453..5701 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52756" /db_xref="UniSTS:377556" STS 5676..5920 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52757" /db_xref="UniSTS:377557" STS 5741..6343 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="ECD10420" /db_xref="UniSTS:291459" STS 5793..7199 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="stSG632975" /db_xref="UniSTS:460342" STS 5895..6119 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52758" /db_xref="UniSTS:377558" STS 6092..6336 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52759" /db_xref="UniSTS:377559" STS 6318..6591 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52760" /db_xref="UniSTS:377560" STS 6528..7028 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="ECD14130" /db_xref="UniSTS:295155" STS 6588..6862 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52761" /db_xref="UniSTS:377561" exon 6719..6779 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /inference="alignment:Splign:1.39.8" /number=2 STS 6843..7074 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52762" /db_xref="UniSTS:377562" exon 6875..6970 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /inference="alignment:Splign:1.39.8" /number=3 STS 7058..7283 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52763" /db_xref="UniSTS:377563" STS 7091..7587 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="ECD14307" /db_xref="UniSTS:295328" exon 7119..7280 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /inference="alignment:Splign:1.39.8" /number=4 STS 7139..7533 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="G67372" /db_xref="UniSTS:186401" STS 7180..8663 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="stSG632976" /db_xref="UniSTS:460343" STS 7259..7526 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52764" /db_xref="UniSTS:377564" exon 7452..7577 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /inference="alignment:Splign:1.39.8" /number=5 STS 7521..7770 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52765" /db_xref="UniSTS:377565" STS 7758..8010 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52766" /db_xref="UniSTS:377566" STS 7773..8292 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="ECD13367" /db_xref="UniSTS:294397" exon 7964..8184 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /inference="alignment:Splign:1.39.8" /number=6 STS 7991..8242 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52767" /db_xref="UniSTS:377567" STS 8058..8292 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52768" /db_xref="UniSTS:377568" STS 8266..8509 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52769" /db_xref="UniSTS:377569" STS 8488..8738 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52770" /db_xref="UniSTS:377570" STS 8599..8742 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="ECD24315" /db_xref="UniSTS:305299" STS 8721..8989 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52771" /db_xref="UniSTS:377571" STS 8778..9964 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="stSG632977" /db_xref="UniSTS:460344" STS 8783..8988 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="GDB:181243" /db_xref="UniSTS:155211" STS 8861..9089 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52772" /db_xref="UniSTS:377572" STS 9377..9607 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52773" /db_xref="UniSTS:377573" STS 9529..10029 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="ECD14131" /db_xref="UniSTS:295156" STS 9580..9828 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52774" /db_xref="UniSTS:377574" STS 9808..10069 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52775" /db_xref="UniSTS:377575" STS 9945..11091 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="stSG632978" /db_xref="UniSTS:460345" STS 10351..10821 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="ECD15416" /db_xref="UniSTS:296433" STS 10352..10576 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52776" /db_xref="UniSTS:377576" exon 10401..10444 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /inference="alignment:Splign:1.39.8" /number=7 STS 10555..10806 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52777" /db_xref="UniSTS:377577" STS 10800..11048 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52778" /db_xref="UniSTS:377578" STS 10880..11349 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="ECD15445" /db_xref="UniSTS:296462" STS 11023..11272 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52779" /db_xref="UniSTS:377579" STS 11072..12315 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="stSG632979" /db_xref="UniSTS:460346" STS 11249..11496 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52780" /db_xref="UniSTS:377580" STS 11289..11525 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52781" /db_xref="UniSTS:377581" STS 11775..11999 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52782" /db_xref="UniSTS:377582" STS 11867..12785 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="ECD00257" /db_xref="UniSTS:281371" STS 11972..12238 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52783" /db_xref="UniSTS:377583" STS 12218..12463 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52784" /db_xref="UniSTS:377584" exon 12287..12369 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /inference="alignment:Splign:1.39.8" /number=8 STS 12296..13397 /standard_name="stSG632980" /db_xref="UniSTS:460347" STS 12449..12699 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52785" /db_xref="UniSTS:377585" exon 12573..13363 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /inference="alignment:Splign:1.39.8" /number=9 STS 12669..12939 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52786" /db_xref="UniSTS:377586" STS 12842..13726 /standard_name="ECD00920" /db_xref="UniSTS:282029" STS 12924..13163 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="REN52787" /db_xref="UniSTS:377587" STS 13028..13237 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="STS-W67447" /db_xref="UniSTS:68922" STS 13078..13182 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="RH67933" /db_xref="UniSTS:25991" STS 13099..13210 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="D2S1596E" /db_xref="UniSTS:150680" STS 13131..13340 /gene="DES" /gene_synonym="CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793" /standard_name="G15847" /db_xref="UniSTS:26731" STS 13149..13394 /standard_name="REN52788" /db_xref="UniSTS:377588" STS 13372..13600 /standard_name="REN52789" /db_xref="UniSTS:377589" STS 13378..14873 /standard_name="stSG632981" /db_xref="UniSTS:460348" STS 13516..13754 /standard_name="REN52790" /db_xref="UniSTS:377590" STS 13734..13984 /standard_name="REN52791" /db_xref="UniSTS:377591" STS 13959..14183 /standard_name="REN52792" /db_xref="UniSTS:377592" STS 14101..14350 /standard_name="REN52793" /db_xref="UniSTS:377593" STS 14191..14437 /standard_name="REN52794" /db_xref="UniSTS:377594" STS 14414..14651 /standard_name="REN52795" /db_xref="UniSTS:377595" STS 14619..14852 /standard_name="REN52796" /db_xref="UniSTS:377596" STS 14829..15099 /standard_name="REN52797" /db_xref="UniSTS:377597" STS 15072..15321 /standard_name="REN52798" /db_xref="UniSTS:377598" ORIGIN 1 caaagctgga ctcttacctt ataccataca tagaaattaa ctcaaaatgg ataaaacagc 61 caggcccaca ttggctcatg cctgtaattt tggcactttg ggagaccgag gtggaaggat 121 cgcttgatcc caggagtttg aggttgcagt gagctatgat ggcaccactg taatccagcc 181 tgggtaacag agcaagaccc tgtttcaaca acaacaacaa caacaaacag acatgatacc 241 taaacataag agctaaaata taaaattctt agaagaaaac aaagaggaaa atcttcatga 301 cattggattt ggcgatgatt tattgaatat gacaccaaaa gcataggcaa taaaataaaa 361 aatagataaa taggacttga tcacaattac aaacttttgt tcatcaaagg acattatcaa 421 cagagtgaaa aggcaaacca cagaatggga gaaaatattt gcaaatcata tatctgataa 481 gggattaata tccagagtat ataaagaact cctgcaactc aacaacaaaa aatccccaaa 541 caacccaatt caaaaatggg caaaggattt gaagacattt tgccaaagaa gatatacaga 601 ttaccagtaa gcgcatgaaa agatgctcaa catcactgat cattagggaa acgcaaatca 661 aaaccacaat gagcagccag gtgtggtggc ttgcttccat aatcccagca ctttaggaga 721 ctgaggcagg aagatcgctt gagaccagga gtttaagtcc tcagtgaggt atgatcatgc 781 cattgcactc cagcctgggc aacagagtga gaccctatct ttaaaaaatg aaataaggct 841 gggtgtggag gcttacaact ataatcccag cactgtgaga ggctgaggtg gaaacatcac 901 ttgaccccag gaatttgaga ccagcctggg caacataggt ttggagacct catctctatg 961 gaaaagtaaa aaaactagcc aggtatggtg gcttgcacct gtagtcctag gtacttggga 1021 ggctgaggca ggaggatcac ttcagtccag gaatttgagg ctgcagtgag tgatgatcgt 1081 gccattgcac tccagcctgc gtgacagagg ccctgtctct aaaaaacaaa acaaaacaaa 1141 caaaccacaa tgaggtacca cctcacatcc attaggaagg ctactattaa tattataaaa 1201 caaataaaca aatagaaaat agcaagtgtt agccaggatg tggagaaatt ggaacccatg 1261 ttcactgctg gtagcaatgt aaaacagtgc agctgctgcg gaaaacagca tggcagttcc 1321 tcaaaaattt agacatagca ttaccatata acatagcagt tccacttctg agtatctaca 1381 gaaaagaact gaacataagt atttgaacag atatttgtac accaaagttc atagcgacat 1441 tattcacaat aaccaaaagt tggaaacaac ccaaatattc atcaacagat aaacaaagtg 1501 tggtgtatac atacaatgga atattattta gccttaaaaa gaaaggaaat tctgacccat 1561 gtcacaacat ggatgaacct tgaagacgtt atgctaaggg aagtaagcca gtcacaaaag 1621 gacaaatatg gtatgattcc acttgcatga agtacctaga gtcaaattcg tagaaacgga 1681 aagtagaatg atgtttacca ggggctggga ggaggggaag gtggagggtt atttttaata 1741 catatggagt ttcagcttgg gacaatgaaa aagttctgca gatggatggt ggggatagtt 1801 gtacaacaat gtgaatgtac ttgacgccac tgaactgtat acttaaaaaa tggctcaaat 1861 ggtgaatttt attttatgta tattttatca caatgtaaaa gtgactcagc tgtcaatgta 1921 ctaaaatgga accatctcta agctgtatgt cattgaaaaa agattgattc agaagtgggg 1981 gctccacata agaaaatgtg gttgtgtgta catgaagtat ctctgaaagg aaccgataac 2041 aaccaaaacc tggttgtctc tgaagcagtg tttggggtgg ctgggtgtca aagtgggaag 2101 gagacttact tttcatttta tgcctttttg cacatcttga attttgtacc atatacacta 2161 cccatccaaa taaattgtcg gtatttttag tgtgtcccat cctgagtggt cctctcggga 2221 ggctgaactc tccctccagc ggtgctgccc agctcacagc atgttttgga gtgctcctct 2281 ttcacctgcc ttccaagcct cggggtgttg atttgcagcc ctccatggta gcaaatcctc 2341 aggggtggaa ctgaattttg aaaacagtcc caagtggttc ggggccaagt ctggtggttg 2401 ttgattttga ctagagaata gatggcatga tttatttgtc ttctgcctct tttcaccaag 2461 gaactgagga cttgggctgg tccaaaggcc aatttcctta tgtggtctgg agatcattca 2521 cagagaagag ctccagaaat gttgtcccag tagcatcata gaaataggtg tagagtcccc 2581 ttcaggaaga ttaatctggt tctttgggct gtaagtgatc aaagcaatac caagtgcctt 2641 aaattaaaaa aaaaaaaaaa aaaaaaaacg gaaagtttgt tggcccaagg ccaggaagga 2701 cagtgtggga gctcaactca caaagttgag ggaagcactg caggaaccaa ggggctggcc 2761 tgctcctcct ctccagcctc ctctgcttct tacatattga cctctctttc ttcctactcc 2821 cccagggggc aggaaacatg gcttccacag gttccagttg aagaatccca gttccgtcta 2881 taaattccag ggaaggtctc tgattggccc tgctcattcc caggcccatt ccttgaccca 2941 gtcactgaag tcagggagat gcagtaataa gactggctgg aatcagggtc tttaggggtg 3001 gagggatggg gaggaggcac agcatgtcat caaaataagg aaattgcaaa agaaagcttg 3061 caggctactt tgaatgacaa tgagaaagac ggtgctgcct gagtgtgtta aggatccaca 3121 tggtctccaa aatcctccag gagcatacag tctagtctgg gagatgagac acaaaaataa 3181 ccagaacaca acagcttgca ctgactcgag ggctggataa gaatatctgg aactccccca 3241 tctatttcag aagcttgtct cttggatgaa aattagacac ttaatgggaa agggctttga 3301 aaagagtgca gtaacaaagc cccctttaca atttacccgg cacattcaca cccatcctga 3361 ggccaaagcc acaggctgtg aggtctcact gtctcagctt cctgagctat aaaatgggaa 3421 tgatgctagt gtctacctcc tagggttgga gaattggggg tcatgggtgt gaagtgctca 3481 gcagcttggc ccacactagg tggtcagtac atgtaaggta ttattgttgc tacatacatt 3541 agtagggcct gggcctcttt aaacctttat agggtagcat ggcaaggcta accatcctca 3601 ctttatatct gacaagctgg ggctcagaga ggacgtgcct gagctggggc tcagacaagg 3661 acacacctac tagtaacccc tccagctggt gatggcaggt ctagggtagg accagtgact 3721 ggctcctaat cgagcactct attttcaggg tttgcattcc aaaagggtca ggtccaagag 3781 ggacctggag tgccaagtgg aggtgtagag gcacggccag tacccatgga gaatggtgga 3841 tgtccttagg ggttagcaag tgccgtgtgc taaggagggg gctttggagg ttgggcaggc 3901 cctctgtggg gctccatttt tgtgggggtg ggggctggag cattataggg ggtgggaagt 3961 gattggggct gtcaccctag ccttccttat ctgacgccca cccatgcctc ctcaggtacc 4021 ccctgccccc cacagctcct ctcctgtgcc ttgtttccca gccatgcgtt ctcctctata 4081 aatacccgct ctggtatttg gggttggcag ctgttgctgc cagggagatg gttgggttga 4141 catgcggctc ctgacaaaac acaaacccct ggtgtgtgtg ggcgtgggtg gtgtgagtag 4201 ggggatgaat cagggagggg gcgggggacc cagggggcag gagccacaca aagtctgtgc 4261 gggggtggga gcgcacatag caattggaaa ctgaaagctt atcagaccct ttctggaaat 4321 cagcccactg tttataaact tgaggcccca ccctcgacag taccggggag gaagagggcc 4381 tgcactagtc cagagggaaa ctgaggctca gggctagctc gcccatagac atacatggca 4441 ggcaggcttt ggccaggatc cctccgcctg ccaggcgtct ccctgccctc ccttcctgcc 4501 tagagacccc caccctcaag cctggctggt ctttgcctga gacccaaacc tcttcgactt 4561 caagagaata tttaggaaca aggtggttta gggcctttcc tgggaacagg ccttgaccct 4621 ttaagaaatg acccaaagtc tctccttgac caaaaagggg accctcaaac taaagggaag 4681 cctctcttct gctgtctccc ctgaccccac tcccccccac cccaggacga ggagataacc 4741 agggctgaaa gaggcccgcc tgggggctgc agacatgctt gctgcctgcc ctggcgaagg 4801 attggcaggc ttgcccgtca caggaccccc gctggctgac tcaggggcgc aggcctcttg 4861 cgggggagct ggcctccccg cccccacggc cacgggccgc cctttcctgg caggacagcg 4921 ggatcttgca gctgtcaggg gaggggaggc gggggctgat gtcaggaggg atacaaatag 4981 tgccgacggc tgggggccct gtctcccctc gccgcatcca ctctccggcc ggccgcctgc 5041 ccgccgcctc ctccgtgcgc ccgccagcct cgcccgcgcc gtcaccatga gccaggccta 5101 ctcgtccagc cagcgcgtgt cctcctaccg ccgcaccttc ggcggggccc cgggcttccc 5161 actcggctcc ccgctgagtt cgcccgtgtt cccgcgggcg ggtttcggct ctaagggctc 5221 ctccagctcg gtgacgtccc gcgtgtacca ggtgtcgcgc acgtcgggcg gggccggggg 5281 cctggggtcg ctgcgggcca gccggctggg gaccacccgc acgccctcct cctacggcgc 5341 aggcgagctg ctggacttct cactggccga cgcggtgaac caggagtttc tgaccacgcg 5401 caccaacgag aaggtggagc tgcaggagct caatgaccgc ttcgccaact acatcgagaa 5461 ggtgcgcttc ctggagcagc agaacgcggc gctcgccgcc gaagtgaacc ggctcaaggg 5521 ccgcgagccg acgcgagtgg ccgagctcta cgaggaggag ctgcgggagc tgcggcgcca 5581 ggtggaggtg ctcactaacc agcgcgcgcg cgtcgacgtc gagcgcgaca acctgctcga 5641 cgacctgcag cggctcaagg ccaagtgagg gcccggcacc ccagactcct ctttctgcgg 5701 gcagggcaca ggaggctagg cctggggtct ggggtcccgc tgtcagcacc tgccttctcc 5761 cggggcccgg gaccctctcc tgccccatgt ggagaaaggg tcctccacct gtgtgtttca 5821 aggggccgtg acctccaggt ctctccccct gcgatcccat cttgcacagg agttttcttg 5881 gggacataga tcagggggtg gatatgggag aatttagggg acccggtgcc ctgtggacag 5941 ccccgttaaa aagcatttta agatgctggg gcgatattta tggggtcagg tagttgatgg 6001 gcagaggaag ggctgcagga ggcccagagg gcagtgtagc cagagggaga agggaggctg 6061 ataggagaca gggaaagcag ggcaagggcc cagagtccaa gcaacagctc tcagctcagc 6121 tgtgatgagg ccctggggga ggtgggggga ggggggagct tggccctggg gccttgccga 6181 gactgtgtct ttttacaagg tgaatggaca ggctggagaa aaagggagta ggtgggggtc 6241 acagctctca gagagcttgg gaggacctga ctgtagactt caccaggctc caagaacgaa 6301 aagggcagca agtgtagcat atttgttggt cccacttctg acaggccaag tgagcacagt 6361 caccctcctg ccaccaaagt cataaatatt aattgagcag ctatattggc caggctggag 6421 ctgggaacca gaaacacaga ggtggataaa atagacacag tttctaaccc cagggaggtc 6481 acacagtctg gtggggacat agacttcaag ggtgtggctc ctgggcagag attgggccac 6541 ttcctgtgcc ctccctgggt gggtggggcc tctccactcc ctgtctctcc tgcctctacc 6601 cagcagccag gccctcccgc tctgtcctgg acccaccccc tggtcagccc ccggccagtc 6661 gtttccactg ccagctttat cacccgcaac tgtctgtctt tctgtctgtc ccacccaggc 6721 tgcaggagga gattcagttg aaggaagaag cagagaacaa tttggctgcc ttccgagcgg 6781 tgagtgccct tcttttcccc ttgcatggcc tctggccttg ctctgcccca cctgggtggc 6841 ggtgaccatg tccttctcgc ttggcctctc ccaggacgtg gatgcagcta ctctagctcg 6901 cattgacctg gagcgcagaa ttgaatctct caacgaggag atcgcgttcc ttaagaaagt 6961 gcatgaagag gtataccttg gcccctcttc ctggggtcac tgggccatgg ggaaagcagc 7021 cggaaagtgg ggttggggtg aggctctggc tgggaatagg ggtgtgaggg tgctgtgtgg 7081 gccctgagag gggactgaag cccagtcatg ccctacagga gatccgtgag ttgcaggctc 7141 agcttcagga acagcaggtc caggtggaga tggacatgtc taagccagac ctcactgccg 7201 ccctcaggga catccgggct cagtatgaga ccatcgcggc taagaacatt tctgaagctg 7261 aggagtggta caagtcgaag gtgggtggcc tcgcccgggg actggcatct ccgtccccct 7321 gaatcccagc ttggatgtgc tgcctgtggt accatccatg ggaggagagc ccagaggctt 7381 catgctccct tgctcatccc tacccgtgcc ctgcatcctt ctcatttttg ggcccctttc 7441 tctgccctta ggtgtcagac ctgacccagg cagccaacaa gaacaacgac gccctgcgcc 7501 aggccaagca ggagatgatg gaataccgac accagatcca gtcctacacc tgcgagattg 7561 acgccctgaa gggcactgtg agtccctgcc cacctggcca ggccctgccc cttcctgtct 7621 gcagttcaca ccctcacttt gtgaccttgg gcccatcata gatcctctct gggccttcat 7681 ctacttaaat ctacaatagg ggtaaaacca gacaagtgga ttccagttgg atgctaagga 7741 atcaggggtt cctgggcatc tacctatgtg gggactgtga ggctgaatgc aatgttcctt 7801 tgtatctatt ttattctgag tgttcacata tagacttaat ttgagttcag ggttcaacat 7861 ggcctggacc tgaccatctg gagttgcctg ccagccccaa agctttcttt gggctgctag 7921 tgtcctcttc ccttccttga cctgggttcc ccctctcctg cagaacgatt ccctgatgag 7981 gcagatgcgg gaattggagg accgatttgc cagtgaggcc agtggctacc aggacaacat 8041 tgcgcgcctg gaggaggaaa tccggcacct caaggatgag atggcccgcc atctgcgcga 8101 gtaccaggac ctgctcaacg tgaagatggc cctggatgtg gagattgcca cctaccggaa 8161 gctgctggag ggagaggaga gccggtgagg ggccaggcag gagcccgagt gggaggtgcg 8221 gggtgctggg tggtccattt ctgtccccag gaggctcgag attactgatt acctcaacaa 8281 gacctggaaa caattttttt tttttttgag atggagtttc gctcttgtcg cccagtctgg 8341 agtgcaatgg caccatcttg gctcactgca acctccgcct cctgggttca agcaattctc 8401 ctgcctcagc ttcccgagca gctgggatta caggcgccta ccaccacgcc tggctaattt 8461 ttgtattttt agtagagacg gggtttcact atgttgggca gctggtctcg aactcctgac 8521 ctcaggtgat ctgcctacct cagcctccca aagtactggg attacaggcg tgagccaccg 8581 cacccggcgt ggaaacaatt ttatacaaga ggccactgct ctattaattg cagagaatta 8641 accaaggcca cctgggtaaa aagcaattta attaacagca tttataaaaa gagaaatata 8701 agtattccct tatccacctt cagaattaag aaccagcagc aaaaaaaacc atattcagca 8761 accaataata aaatattact gccagtcaag ggagagatga aagcagaatg gggagtgatg 8821 aggagggaaa cggagggagc agatagaggc aaatagagag agggagggag agaagccttg 8881 cacagggata ggctaagaga aggtaaagag atgcatacag aaggcatgag tttgcacaca 8941 catgcacaca tgtcagcata tgcacatgtt cggaggaaaa gacacagacg tcatgctcag 9001 agcaacccac ctctagacac agaaaacaac atacaactgg aaagggacac cagggaacct 9061 tgtgggataa cagaaatgtt ctatatcttt tttttttttt ttttttgaga cagagtcttg 9121 ctctgtcacc caggctggag tgcagtggtg tgatctcagc tcactgcaac ctctgcctcc 9181 caggctcaag cggttctcct gtctcagcct ccctagtagc tgggattaca ggcgtgtgcc 9241 aacacactca gctgattttt tgtattttta gtagagatga ggtttcacca tgttggtcag 9301 gctggactct aactcctgac ctcaagtaat tcgcctgcct cagcctccca aagtgctggg 9361 attataggca tgagccactg tgcctggcct agaaatgttc tatatcttga tttggactgg 9421 tagttacaca gacgtggaca ttgatcaaaa ctcattgaat tgtacattaa agatctgtgc 9481 atttcactgt atgtaaattt aacctcaatt taaaacagat cagttactcc aaaaactggt 9541 accccttgat actcataaaa ataatatctg aaatttttaa aaaggagcag acatgtttag 9601 atacaggtac aaacataaag agaaacttca gattttgtaa aatcacgtct acatatgatg 9661 gcctttgaag gtagctaaag gcatgttgca ttttcccagc attaggccta aatagtaagc 9721 tctcagaact ggcctggctg gagggtgggc atgagcaatg gatatcaccc acagctgcta 9781 ctagtaccaa cttcagtgcc aggagcaaga aggaaatcct ggtgctctgg agggcgcggt 9841 ggggttgcac atcctagtgt cgtgccagca gttcacagtt gaaataatga tccttccaga 9901 agagactatt cctgggacag ctctagctgg ccttcgaccc cattccttga gcagtatggg 9961 tggtgggagt gctggggtcc gtgggactgg gacagctgag gatggtgttt agaaaggacc 10021 agggtgagcc ttgatgggcg gtctcaggga aagatgggag ggttcttttt tttttttttt 10081 tgagacaggg tcttgttctg tcccccaggc tggagtgcag tggtgcaatc tccgctcact 10141 gcaagctcca cctcctgggt tcgcaccatt ctcctgcctc accctcctga gtatctggaa 10201 ctacaggtgc ccgccaccat gcccggctaa ttttttgtat ttttagtaga gacggggttt 10261 cactgtgtta gccaggatgg tctcgatctc ctgacctggt gatccgcccg cctcggcctt 10321 tcaaagtgct gggattacag ctgggcccgg ccgatgggag ggttcttaac tcttaggagg 10381 ttttgtctct tcccttttag gatcaatctc cccatccaga cctactctgc cctcaacttc 10441 cgaggtgagt gtctgctggc aggcggaggc tggagttgca ggggccagga gtccagcatg 10501 ggcactgccc aaggccagcc aggagggagg atgggaccct ggggctaggg acagacctgg 10561 agtctgggga agaaaaaggg gaccactgcg ggtaggtggg ggagtttagg tagaggtgga 10621 tgaggcaact tatgacagag agagcttttt atgtgattat attgtattgt atttaccatg 10681 tcccctgcac cttcttggag tattgggcct caggaagcag cctctgttct gaatcccaaa 10741 ctctgaaagc aggagtgtcc ttggggacct ggcttcagga gcatctcata ccacctgccc 10801 tctaagacac ccacagccca ttgtctgttt ggcacattgc caagccccac cttggctgct 10861 tgtcgaacac ctccagtttg ctggagcaag atgttggatg cacgtttgga aaaaaatgcc 10921 aaatcttagc aaagccaaac aatgaaaaga acgagctctt agggcactct gccattttga 10981 cattagtaat acgcagatcg ggtggctttc caaccccaga gagcagagaa acacacgata 11041 atgatgcatt aggaaagcaa gtcggagtcc ttggcagctt ctcctttcct agatcaaacc 11101 ttttctatct tcgatgtaca tttccatcag gaaaaaaaac acgctgcgct ccagcgagtc 11161 acaacattca tcacaggctg gttgctagct aaggaaattc gtaagcacca aactcataat 11221 accaaggacc tccatttgac ctttcctaca caactcagag cctctctttt cagttagttg 11281 tttatacaga caccaagtat gagtcttgca tttaaaactt catagtacaa aaaactccac 11341 ccacattgca cagtgctttt ccaaatcaat agctttgtgg ccatgataag gttggtacca 11401 cttcactccg tgtcctcagt gaggaaactg aggcacagaa tggcaagtga ctgagcatca 11461 gcacaatgag tcagtgcctt attcctgctc tgtctcactt taagacatca agttgctcat 11521 ctgaattttt tttttctttt gaaacggagt ctcgctctgt cgcccaggct ggagtgcagt 11581 ggtgcaatct cggctcaccg caacctccgc ctcccaggtt caagcaattc tcctgcctca 11641 gcctcctgag tagctgggat tacaggcatg tgccaccacg cccccctaat ttttgtattt 11701 ttagtagaga cggggtttca ccatgttggt cagggtggtc tggaactcct ggcctcatga 11761 tccacctgcc tcggtctccc aaactactgg gattacagat gtgagccacc gcacctggcc 11821 ctgaaatctt aaagggagat aggtactgta aggtcctcta aagagtgtct tgagactggg 11881 ctttggggtt ctatcttgaa gaaggggagt cccaggagac aaatgtgtgc agggctctcc 11941 tggggcctgg gggtggagag gaactaggag ggatggggaa tgtcagtgct gtgcagcctg 12001 ggcctcaggt gtcccctacc ctcctgcacc atcctgcaca tggagcaaat ctgttggctc 12061 ctgagaccat ctaaactatg ggacaggcgc tggggactgc agaaccacct gctgggtgct 12121 gggctgaagg aaaggtgtta aagtcttgaa gaagtaacaa gcctgtcttg aggggggttg 12181 gggtctgcta gggctctgcc caatgtggcc ccagatggac tcccagcccc tggtatagcc 12241 cagcctggac ttggtcaggc tgagtgtgcg atggaccctg ttacagaaac cagccctgag 12301 caaaggggtt ctgaggtcca taccaagaag acggtgatga tcaagaccat cgagacacgg 12361 gatggggagg taagtggtct gtctgggctc cttacccttg gtgggggcta tggatgtgtc 12421 tggggggact gtcttccacc cagctgtgct ggtctaggtc cctggctagt ggggcaagag 12481 agatcctgcg gccctggggt ggggatggct cagggctgag gctccattct ctggctagca 12541 catggttgga ctgggcttct cttcctcccc aggtcgtcag tgaggccaca cagcagcagc 12601 atgaagtgct ctaaagacag agaccctctg ccaccagaga ccgtcctcac ccctgtcctc 12661 actgctccct gaagccagcc ttcttccatc ccaggacacc acacccagcc tcagtcctcc 12721 cctcacagcc tctgacccct cctcactggc catccctcgt ggtccccaac agcgacatag 12781 cccatccctg cctggtcaca gggcatgccc cggccacctc tgcggacccc agctgtgagc 12841 cttggctgtt ggcagtgagt gagcctggct cttgtgctgg atggagccca ggcgggagcg 12901 gtggccctgt ccctcccacc tctgtgacct caggcactag cctttggctc tggagacagc 12961 cccagagcag ggtgttggga tactgcaggg ccaggactga gccccgcaga cctccccagc 13021 ccctagccca ggagagagaa agccaggcag gtagccaggg ggactagccc ctgtggagac 13081 tggggggctt gaaattgtcc ccgtggtctc ttactttcct ttccccagcc cagggtggac 13141 ttagaaagca ggggctacaa gagggaatcc ccgaaggtgc tggaggtggg agcaggagat 13201 tgagaaggag agaaagtggg tgagatgctg gagaagagag gagaggagag aggcagagag 13261 cggtctcagg ctggtgggag gggcgcccac ctccccacgc cctcccctcc cctgctgcag 13321 gggctctgga gagaaacaat aaagagattc acacacaagc caagctggcc cctgttgtct 13381 tgactgccag gtctcctgtg gggcccctgg ggccctgtga tacaacctgt caccctgaga 13441 tggactatac tgaccttcta cccagccaga ctttccccag ggcctcgcgc ccacttctgt 13501 tcccagagcc acctggcctt gatgtctgta tgcagtgtat ggggcaggga gggctggaca 13561 gggcttttgt tggggaacca caaatacctc tcgttaggcc ccagttccag gactgcaccc 13621 cttgtgctct ctactacacc ttcaggtcag ccaggctggg ggacaccacc tgctattcct 13681 tttgaaggat gtagctgctc cccactgact ggctctgaag tagggctccc ccagtccctt 13741 cttcaaagat gccaacagcc cctttttttt ctctctctct ttttttcttt ttgagatgga 13801 gtcttgctgt gtcacccagg ctggagtgca gcagtgtgat cacggcttac tgcagcctgg 13861 acttcctgag ctcaagcgat cctcccacct cagcctccca agtagctggg accacaggtt 13921 cacaccacca tgcctggcta gctttttatt ttttgtagag acaaggtctt tctgtgttgc 13981 tgaggctggt cttgaatttc tgggctcaat tgctcctcct gctacctcag cctcccaaag 14041 tgttgggatt acagatgtga gccaatggcc tctttctatt aactccttcc aatactattt 14101 ttatacacag gagccaattc aggaaaaata atgtttggaa aaatggaaag atctgttctg 14161 tgcttcgata agaaggttca atactctgaa gagaagtcaa ttcattttcc attcatctat 14221 aatttcaatg ccatgcaatc tcaattaaaa taccaaataa aaattttaag agaattggag 14281 aagatgggag gggagtgtaa gacgtatgaa aaaaattagg aggctgggca cagtgactcc 14341 acctgtaatc ccagcacttt tggaggctga ggtgggagga tctcttgagc ccaggagttt 14401 gagaccagct tgggcaatgt aacgagaccc tgactctaca aaaaataaaa aattagcctg 14461 gcatggtggt atgagcctgt agttccagct acttgggagg ctgtggtggg aggatagctt 14521 gagcccagga ggtcgaggct tcagtgagct gagattgtac cactaactcc agcctgggtg 14581 acagagtgag actctgtctc aaaaaaagaa aaaggaaaaa aattaggaaa tcatagaaag 14641 aacatcaaaa tatattagaa ggctatgata attaacagat ttgttaatga agaggaaata 14701 tacaaatatt aatgaacaaa atagtgtgtt tagaacaaga ctcacataca ggagacatac 14761 acatgttaaa ggaggcattt tgaatttgtg gggaaaactt aatgattcag tatagggttt 14821 ggagcacttt gatagctaag aggtggggta gggggcagag tgaaggctgt ctctctttta 14881 ctccttctaa aaatattcca gtggatcaaa gatgtaggaa acgatggatc catgtaggcc 14941 tcagccttca agtttctcct ctgagatttc agggattatc ctttaaagga gtcaggaaga 15001 gggtagagat cacaaagata ataagctcag acagtttgta tgttaaataa acctcaggag 15061 gttttagtct taaggtcctt aatctgacct tccaaactga cttttccaga aacttccaaa 15121 agcctctctg gtgtctcttt cttcccctcc tttaatgtgg ccctggctca caagtcaccc 15181 ctctctctaa gaagtcccct tctctgtttt attcttcagc tttgccccag gaggacctgg 15241 ggtgtagccc catgtcccct ccctctgcca ctggtgactc atggtcattt cattcccctc 15301 agtcctcaaa tagggtgaac cctacaggcc ccagaactac cccagtcaac ctgtagagaa 15361 act //