LOCUS       NG_008037              14638 bp    DNA     linear   PRI 04-MAR-2010
DEFINITION  Homo sapiens crystallin, beta A1 (CRYBA1) on chromosome 17.
ACCESSION   NG_008037
VERSION     NG_008037.1  GI:190358494
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005412.8.
            
            Summary: Crystallins are separated into two classes:
            taxon-specific, or enzyme, and ubiquitous. The latter class
            constitutes the major proteins of vertebrate eye lens and maintains
            the transparency and refractive index of the lens. Since lens
            central fiber cells lose their nuclei during development, these
            crystallins are made and then retained throughout life, making them
            extremely stable proteins. Mammalian lens crystallins are divided
            into alpha, beta, and gamma families; beta and gamma crystallins
            are also considered as a superfamily. Alpha and beta families are
            further divided into acidic and basic groups. Seven protein regions
            exist in crystallins: four homologous motifs, a connecting peptide,
            and N- and C-terminal extensions. Beta-crystallins, the most
            heterogeneous, differ by the presence of the C-terminal extension
            (present in the basic group, none in the acidic group).
            Beta-crystallins form aggregates of different sizes and are able to
            self-associate to form dimers or to form heterodimers with other
            beta-crystallins. This gene, a beta acidic group member, encodes
            two proteins (crystallin, beta A3 and crystallin, beta A1) from a
            single mRNA, the latter protein is 17 aa shorter than crystallin,
            beta A3 and is generated by use of an alternate translation
            initiation site. Deletion of exons 3 and 4 causes the autosomal
            dominant disease 'zonular cataract with sutural opacities'.
            [provided by RefSeq].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14638             AC005412.8         87479-102116        c
FEATURES             Location/Qualifiers
     source          1..14638
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     STS             1090..1245
                     /standard_name="D17S1157"
                     /db_xref="UniSTS:33612"
     gene            5001..12638
                     /gene="CRYBA1"
                     /gene_synonym="CRYB1"
                     /note="crystallin, beta A1"
                     /db_xref="GeneID:1411"
                     /db_xref="HGNC:2394"
                     /db_xref="MIM:123610"
     mRNA            join(5001..5038,7286..7350,8326..8444,10208..10349,
                     11784..11926,12346..12638)
                     /gene="CRYBA1"
                     /gene_synonym="CRYB1"
                     /product="crystallin, beta A1"
                     /transcript_id="NM_005208.4"
                     /db_xref="GI:169790959"
                     /db_xref="GeneID:1411"
                     /db_xref="HGNC:2394"
                     /db_xref="MIM:123610"
     exon            5001..5038
                     /gene="CRYBA1"
                     /gene_synonym="CRYB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(5008..5038,7286..7350,8326..8444,10208..10349,
                     11784..11926,12346..12493)
                     /gene="CRYBA1"
                     /gene_synonym="CRYB1"
                     /note="eye lens structural protein; crystallin, beta A3;
                     beta-crystallin A3"
                     /codon_start=1
                     /product="beta-crystallin A3"
                     /protein_id="NP_005199.2"
                     /db_xref="GI:12056461"
                     /db_xref="CCDS:CCDS11249.1"
                     /db_xref="GeneID:1411"
                     /db_xref="HGNC:2394"
                     /db_xref="MIM:123610"
     exon            7286..7350
                     /gene="CRYBA1"
                     /gene_synonym="CRYB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     STS             8003..8240
                     /gene="CRYBA1"
                     /gene_synonym="CRYB1"
                     /standard_name="GDB:180957"
                     /db_xref="UniSTS:155144"
     exon            8326..8444
                     /gene="CRYBA1"
                     /gene_synonym="CRYB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     exon            10208..10349
                     /gene="CRYBA1"
                     /gene_synonym="CRYB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     exon            11784..11926
                     /gene="CRYBA1"
                     /gene_synonym="CRYB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     exon            12346..12638
                     /gene="CRYBA1"
                     /gene_synonym="CRYB1"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     STS             12492..12741
                     /standard_name="RH79897"
                     /db_xref="UniSTS:85206"
     STS             14028..14235
                     /standard_name="RH80000"
                     /db_xref="UniSTS:86326"
     STS             14224..14371
                     /standard_name="RH98857"
                     /db_xref="UniSTS:90504"
ORIGIN      
        1 gccctctaga aaactagact gacagaatac gctgctaaaa tttaataaag aaaaatatcg
       61 gaaaacaaga aaaatggagt gaattttcca aattcaaagg aaacattttt tatctgaatt
      121 ttttttctaa aatctgtgct acttgctccc acttgtctct atgagaattt agcaaaagat
      181 ggtatctgac ttggcacagt cagtaatgca attaccatgt ggtgatgagt tctgagtacc
      241 tagcattgct ctaaatccct ttatttccct tcatctgata gcagtggtta aggtagatat
      301 tatcacccta ttttgtgcca ggaagaaaga agatgggctt tgcagtcaga tagacatata
      361 ctgaagtccc tgctaggttc cctggcccag aacttccctg gcctctcaga acctcagtta
      421 gctcatctgt aaaatgggta ttattatcta cttcacggca ttgtggtaag gattacaaag
      481 acactgtctg gttttgcagt caatgctcag taagctgtag ttattattaa taaggatgaa
      541 caggagagac ccatactcag cctgggagaa gggattccaa gctggttgct cccttcatta
      601 ccactccttg agtggctctg ctttaacttt cctggaatga gatggggctg ggggctgccg
      661 caagggaagc agcagtgcca gacaatgtca gagggggaat ccgccagaac tctgttaaaa
      721 actatattga gttgacattt ggaaggcttg gtggtcagta ctggagagct gagaatcctc
      781 aatctttcag gacttaaggt gattgagaaa agtggattga ggccagatga ggacttatga
      841 ctccaggaat gtatgatgga tatttgtaaa ttgttctcac aataaccctg attcccaccc
      901 gaccaccact atagttctgt gcatgtgtgt ttgggctttt caatcaaaca taaaagcctc
      961 gcttctctgc aaaaattaaa aattagctaa gttgatctcc atgtactagc aattcagtag
     1021 gatgtaaagc ccccatatta cgatgctgag ggtgtgtgaa gcccaagcag gccagttgtg
     1081 gctggggtga gaaggccaaa ctcagctggg tgctcctagc aataaggact atgccaccag
     1141 aatcacaaaa cccagtcatt cattcattca ttcattcatt cattcggaat atacttattg
     1201 agctagaagg tatgcttaga gccgaagacg taacaatgac ccaggcaggc tgcagtggct
     1261 cacacttgta atcccagcac tttgagaagc tgaggccagt gaatcccttg agtccaggag
     1321 ttcgagacct gcctgggcaa catggcaaaa ctctgtctct acaaacaaat acaaaaatta
     1381 gctgggcatg atggcgcaca cttaccatct cagctacctg agaggctgag ttgggaggat
     1441 cgcttgagcc cggaaggtgg aggttgcagt gagccatgat cgtgccactg cactccagcc
     1501 tgggcaacag aatgagaccc tgtcttaata aaaaaaaaaa agagaaagaa acaaccaaaa
     1561 aaaaaaaaaa cctcagtgaa ctagacagat gaggctcctg cccttataga gcatggaggc
     1621 tagtggaaga attagatagg taaacaatgt tttatttttt aaaatcactt agtcttaata
     1681 gaaaatatgt tcccaatgtt caaaatttaa agattacaga aaaatatact atgaaaagtc
     1741 ttgtcctgta tctgaggccc aagtgcctca gtttccccca acatttggaa accagtactt
     1801 ctagttccta aagcaatttc tgcagcatga tcaatgtgat cttgtgtaat tggaaaagca
     1861 caggatgaca tgaggacaca ctgtgagggc ctaagccagc ctaagagtgg atgattgaaa
     1921 aaatgactaa atgagtgttt cccaaagacc ctaattctga agaaaggaag gaggaagaga
     1981 agggaaagga aagaagaatc accaaccata gacagctagt gctttaagcc cttgcacagc
     2041 caccaggtgg ccagagcatg ctatgatacc aaaagcaact ctgtcccctg ccagacatcc
     2101 gtccagacat cacgagttaa tcaaggcatc agaaacatcc ttggggcgat gtgccatgct
     2161 tagcatcaga tttatatgtc taacagcaag tttgtccaac cggcagcctg caggtggtat
     2221 gtggcccagg acagttttga atgcatccca acacaaatta ataaactttc ttaaaacatt
     2281 atgagatttg ttttgtaatt tttttttagc tcatcagtta tcattagtgt tagtatattt
     2341 tatgtgtggg ccaagataat tattcttcta atgtgcccca gggaagccaa aacattggaa
     2401 acccctggtc tggaacgttc tacccaaatc tgcaaatact cgaatacata ccagacctca
     2461 ccccctgatt tttggttctg aagaaaaggg gccactgatg aaacttgagt cggggactgg
     2521 agagattgca gaggaattga gagaactttc tttttctctc caagctgcta tgaaattttc
     2581 ttttttcttt tttttttttt ttctgagatg gagtctcgct ctgtccccca ggctggagtg
     2641 cagtggtaca atctcggctc actgcaagct ccgcctcccg ggttcacgcc attctcctgc
     2701 ctcagcctcc caagtagctg ggactacagg cgccgcccgc caccacgccc ggctaatttt
     2761 ttgtattttt agtagagatg gggtttcacc gtgttagcca ggatggtttc gatctcctga
     2821 ccttgtgatc cgcccgcctc agcctcctaa agtgctggga ttacaggcgt gagccaccgt
     2881 gcccagcgaa attttcaata gtatctttca ttggaaagag agtagggtaa ggagtcataa
     2941 gcctacaatg tatcaggcag atattctatt tttgaggttg agagagtctg agtgacttgc
     3001 ttcaaatctc ccagccagga aactgggatt tgaacccaca tctgcctggc tcaaagcctt
     3061 ccacatccat tgcagcctct tgcttctcac aatatctgtg atgcttgcag aacacatctt
     3121 ccccttcagg gcccctgcgg aggcccacga ttcccctacc ttaccttcat caagtgtcct
     3181 gaagtttctg ggagaagtca ttttacactt taaggtacta tacgcatagt aacttgggcc
     3241 tgtgagattt ccaaagacct aaaacaattc agtaaaacgt caaaattggc cgggcacagt
     3301 ggctcacgcc tgtaatctca gcactttggg aggccgaggc aggcagatca cttgaggtca
     3361 ggagttcaag accagcctgg ccaacatggt gaaaccctat ctctactaaa aatacaaaaa
     3421 aattagccgg gcatggtggc aggtgtctgt aatcccagct actcaggaga ctgaggcagg
     3481 agaatcacct gaacctgggg ggcagaggtt gcagtgaggc aagatcgcac cactgcactc
     3541 cagcctaagc aacagagcga cactctgtct caaaaagaaa aaaaaaattg gttttgaagg
     3601 tgtgggtggc aggaattctc gcccctggcc tgggtgagct agaggggaga agcaaggaca
     3661 tctaggtccc tatcaccgct tgcctagaca acttcacagg aaggcccccg ggaatctgag
     3721 atggagcagg tgaacccttt acatctagat ggtgagtcca aaggaggtat tcagaaggtt
     3781 gccttcttcc ccttcctact gctgcccaac gatgacccgc aggctgaaag agccctttcc
     3841 tcctggaact gatgtgggac ctggcctgtt tgggagcaga atggtgaaag gaattaacat
     3901 ggaagacaaa gggacaggca gccaagatca tttgaggagg aaaaattgct tcatttctag
     3961 gctccttccc cttttgaaac agataagtta catccattat atgctcagtg tttatattca
     4021 gaactgcagt tctagccagg ggggtctctt tcctctcctg gaattttttg ggccatttat
     4081 gcattactcc tgagggaggg ccagtgcagg gcagtgactt tggtgttggt tagaactgga
     4141 ttcgagtctt ggctctgcca ttataaatac tgtgacctta ggcaagtcac ctgattgttc
     4201 tcttagtttc ttaatctgga aaatggaggt gaaaatagca ctgttgtggt ggctgtgaaa
     4261 aagtatttct ttcttttgtt gtggaaaagt atttaattca aactttttaa gtaaagcatt
     4321 tagcacatgt ctaatatata ggaattattc aataaatggt ttaattcttt tttaaaaaac
     4381 ccaaaagtta tagctccaaa atttttaaag aaaattgcaa aattaaaagg aatatttaat
     4441 aaaatagcta cagagagaca catgtctgct agtcaactat aattgaagtc aacccttaca
     4501 tagttatata taaatacagc ataataaaga ttcccaagaa tacaatgaac cattttttct
     4561 catattgagt tcagaattac aataattctt tcacattttt aaacaacaag aaatgcacat
     4621 ctgtatggaa gtgaggtgca ttttgatgtg tttgatatga catggggtct cccagggtct
     4681 taaggtctta ggaagatccc aaggtggtgt gaggaacctg gagaaggaca agagacaagt
     4741 actcatggca gagacttctg tcctcacccc ctagctgctc tgagagatta agaaagccaa
     4801 ggcctgcagc agccagccat gcccacaaca gaggggcctc tctggatttc tgtatccctg
     4861 gtttaaacaa aggccccagc aagctgagcc accaaagctc tggggatcat gaggaacaaa
     4921 ggcagaggga gagcagagtg ctgacagggc cagaggccag aggccgcagg gctataaaga
     4981 ggagggccac agagcaagtg gtaccagatg gagacccagg ctgagcagca ggagctgggt
     5041 gagtaaggcc ctcagggtgc ccttgccctt cctctccttg ccctgcagag acatgcccag
     5101 gagagggccc agttctcctg cctagtgtgt agagccttct agggtggctg gagaagagtg
     5161 gggaactctg gcggaagaca gccttctctt gtcaccccaa gaggagtcac ttatatagca
     5221 ataaccactg ccctagcaac taaggctggg ggatgggcat gggcccccaa gaaacgagca
     5281 gggagaaggt atgggagcag gacctgggaa atgttgctta ttcagagatt cagaatggaa
     5341 aaatatatta cagagttgac atgcatcatt cctgggccca ataccagcca ggaggagggc
     5401 catgaatatc tgtcctaaga aacctaatac acacctgcct gtcttccttc ttcccttcct
     5461 cccccacttt tccttcctct ttcttgctct gtccttcctt ttttaaaact cgtcctacca
     5521 tcttcactgt ctacctaacc tctttgagcc tcagtatcct catctgtaaa atggggataa
     5581 tgataattct taattcatag tctgtatgtg aagattaaat gcatgaatgc atgtaaagca
     5641 tttaaaacag ggccggacat gtagatagcc atttttgagt gtaagtatta taactctttt
     5701 cttcttcact ttccttcaat aagtcttttt caatgtcccc ctgatccctc atctccacat
     5761 gtgctcagca cgatgctata ccaatcccct agaagaccga ggccttgcca ttgaggtgct
     5821 caccaggaca tccaaccaga acacagattg gtactgtgat gagtgctata aatcaagaaa
     5881 gcaagcaagt ggctgtgggc tggagaaggc aggaaagcct ctgagaaggc aaggtcaagg
     5941 ctgggtagga tctaggagat agaaaagcag aaaggaatgg ccaggcgccg tggctcatgc
     6001 ctgtaatcgc agcactttgg gaggccaagg cgggcagatc acctgaggtc gggagttcaa
     6061 gaccagcctg accaacaggg agaaaccccg tctctactaa aaatacaaaa ttagccgggc
     6121 gtggtggcac atgcctgtaa tcccagctac tagggaggct gagacaggag aatcgcttga
     6181 acctgggagg cggaggttgc ggtgagccga gattgcgcca ttgcactcca gcctgggcaa
     6241 caagagtgaa actctatctc aaaaaaaaaa aaagaaaaag aaaagcagaa agaggccaga
     6301 taaggatgag accgtgaagg gttacgaggg agtctggggc ttgggatcct ggcatggctg
     6361 gctgtttggc cagtcacatg aggggtctgg cctaggtggt tgccaaagag tttatattgc
     6421 agacagaggt aatgctgtca cctgaaagca agtgagagga cagggtctca gtgctttacc
     6481 tgcattattg tttctgatcc ttgttttttt tctttttttt ttttttgaga tggagtctca
     6541 ctctgttgcc caagctggag tgcagtggca cgatctcagc tcactgcaac ctctgcctcc
     6601 cgggttcaag cgattctcct gcctcagcct cccgagtagc tgggactaca ggcgtgtgcc
     6661 atcatacccg gctaattttt gtatttttag tagagacggg gtttcaccac gttggccagg
     6721 ctggtctcaa actcccgacc tcaggtgatc cgcccgcttt ggcctcccaa agtgctggga
     6781 ttacaggcgt gaaccaccgt gcccggccta ttatttctga tccttacaat aactgcatgt
     6841 cgaagcttta ccaatggaaa aactgaggct caggctgggc gcggtggatc acttgaggtc
     6901 aggagtttgg gaccagcctg gccaacatgg tgaaaccccc atctctacta aaaatacaaa
     6961 aactagctgg acatagtggt gcatgcctgt agtcccagct acatgggagg ctgaggcgga
     7021 aggatcactt gagcccagga ggcagaggtt gcagtgaagt gagattgtgc cactgcactc
     7081 cagcctggat gacagagaaa gaccctgtct caaaatagca acaacaacaa caacaaaccc
     7141 cgaggcacag ctagtgagca gcagagccag aatttcaacc aaagtctgtc ttgcagactt
     7201 caagtctcct ttacctttca aggcattccc tcacctcccc ctcctcccaa gaggccacat
     7261 cattcgtgtg tgctctgtct tccagaaacc cttccaacca ccaagatggc tcagaccaac
     7321 cctacgccgg ggtccctggg gccatggaag gtaagcccac ccccatcaca tccaacaggg
     7381 caggggtgac atgctgcaca gagcaggccc caggcctgtg ctcgtccata aggcagtgac
     7441 tgaccagaaa aaccccagtt tgtaggggaa aggtccacac aagctccagt gctgtcgaag
     7501 gaaggatctc tcaggatgtc ccactggaca aaggaaggat gactgtggat gccattgatg
     7561 ggtgggagat gatacctagt ttcctaactc ctctctcctc cccactaaag tcatcttaaa
     7621 atacagcagc ccagcaacag ttatgtccat ggagaaaatg agggcccata aagatattta
     7681 ctactagatc ccaaataaat tacaggactc agcctcccat cctgaggttg gctttaacca
     7741 ttggccgaag tggctgatcc tcaggcctct cactggcctc tctccaacac tccccactct
     7801 cctcattggg tcaactctga ggccagctca cagctttgcg agtggtcctc tggccaggtc
     7861 cacgagccag gttttagttc aatgtacaaa aagggttgac cataactctc ctttacactc
     7921 taggtttcta tagggggtat ggctggagaa gctaagaatc tataaggagc tcctgggact
     7981 cccagaatcc tggcctctgg gccatgctta tgaaggaact gtggtggaat gggagcccat
     8041 aagtccttgg cctgtccatt ggtctagata ttatccctgg cagaccattt ctatcataaa
     8101 ccaatcctcc ctccacctca tccctactct gggcaaatga acaccaacca gtggcattaa
     8161 ttcaaacccc ttcctgccct gtctacactg gaagagacct catcaggcat cccaggctac
     8221 agctggtaac agaaagcaca gagtcagact gaagttaagc tgttgacctg gacctctgtt
     8281 tttcctgatg ttctagctct cttgcgccat tcaatctcat ttcagataac catctatgat
     8341 caggagaact ttcagggcaa gaggatggag ttcaccagct cctgtccaaa tgtctctgag
     8401 cgcagttttg ataatgtccg gtccctgaag gtggaaagtg gcgcgtgagt atggacttcc
     8461 gcagaaccgc agccccttat ttcaggtccc ttcagacagg ggaccataga gtggggatag
     8521 gggaagaagg atgttcccct aggctctagt catttctcgg agacaggcct cgaaagaaat
     8581 cactacatgc ataatttagt aagccaaagc tagaaggaag gaacatgagg ttcttagtgg
     8641 cttggtacta gatttcaggg gctggataaa gaaatacata caatggggtg ggacagtggc
     8701 agtaatcaaa attttgcttc tggagctcac aggctgctac ctagggtgcc ctcagaacag
     8761 ccacaagacc cttgagtttt tcttgcctgc agaaaattgg tagagaagaa agtgtcaagt
     8821 ggctgcctct tcatggctaa ctctcctcct gcatatccca gagcagacac tgttagctaa
     8881 tttctttatg aaaaaaaaaa ccttaacccc acgactccag agacatatta gctcctgatt
     8941 catctttcag gcagtttctt gttgatggtt aatcttggtg agggagaccc tctcattttt
     9001 gtcctctgac tcttggcaga gtagttgagg cctttatcat tagcctgaaa atacctaagg
     9061 aaaagactca cccttgacta ggcagaattg gccttgcatg tggataggct tccacaagtt
     9121 gcttgccacc aaaattaagc tcttcagtcc tttaaaagat gtaacacttt aaggtgtcat
     9181 cactaactga gacccagttg tgaaaaactg agctgagtgt ttcaagtttt aagtacaggt
     9241 atggggcact aggagaaaga actcgcaagt cacaggaaga aaaaagacta gtaatccatc
     9301 agttgcttgt tcatccctgt gctttcttaa gaagaagcca acaggtttgg cttgagccaa
     9361 agcaatagtc caggggtgtc taatcttttt ggcttcccta ggccacactg aaagaattgt
     9421 cttgggccac atataaaata ccataacgat agctgatgac ctaacaacaa caaaaacaac
     9481 tcataatgtt ttgaggaagt ttacaaattt gtgttgggct gcgttcaaag ctgtcctgag
     9541 ctgcatgcag cccttgggca acaggttgga caagcttgca acagtcacta gatcctgaaa
     9601 caggtagaga ataggtgatt tggagaaaaa gaaaaaaaaa tttttttttt ttttgaggca
     9661 aggtgtcact ctgttgccca ggctggagtg cagtggcaca atcatggctc actgcagcct
     9721 ccacctccaa ggctcaaccc tcagccccct gaatagctgg gactgccagt agtgggtcac
     9781 cacgcctggc taatttttga gttttgtaga cggggtttcg ccatgtttcc caggctggtc
     9841 tccaactcat gggctcaagc gatctgcttg ccttggcctc ctgaagcgtt ggaactacag
     9901 gcgtgagaca ccacacccag ccaggaaata taattttaga ttggctttgc taatacactt
     9961 cactcagacc agtgaagtag atagaccttt tcagtgataa cccccaaaca aatattacat
    10021 tcactaacct gcttagtata cctgtcaact cattcctcaa ctcttgtgac aaattacttt
    10081 gtacagctct actgggattg gcttgatatt ttaccccact attgacttat ctaaaacgaa
    10141 agatgccttc tccccaaggc catataggct ttgaacacca tgaacaaaca ctacatgtct
    10201 ttggcagctg gattggttat gagcatacca gcttctgtgg gcaacagttt atcctggaga
    10261 gaggagaata ccctcgctgg gatgcctgga gtgggagtaa tgcctaccac attgagcgtc
    10321 tcatgtcctt ccgccccatc tgttcagctg tgagtctctg aaatttccac ttccgtgcat
    10381 atgagggatg ggacaagagg gtgtggacag actgacgttc atgctattta tcatcagtta
    10441 tgctgaatgt ggcaggaaaa aagacaaaag taaaaaaaga gaaaacatca ctttcttctc
    10501 taagcctgct atttgatttt tctccaccag gtggtacttc ccttaagcta aaactaaggg
    10561 tcttacaagt ggcaataagt ggatactcaa gagcccagta aacttgtgaa acactagtaa
    10621 atgagtgaaa gtgcttaccc tgcagcaaaa agtaaatcct tggccagtta aatttcaatc
    10681 tgtgtaacat ttttactgca gaaacaggaa aatgctgaag taacctttca gtaagtggga
    10741 atgactgacg aaataggcaa gtcttccagt atcgatctac actgattgat aataatcttc
    10801 ttgttctgaa cacttaagta ttactcaata atgcatcagg ctgggatgtt tctggtcttt
    10861 ggaaacagtt caagcagaaa gcagaatgac cttaaggggt gtgttgaaaa tgatccctgt
    10921 attaggagtt aggttgggct agaacctttc caaatattca gtctatgtga gagtttctcg
    10981 tgattttggt taataatctc atcttggttc aaagtcttgc caaaattcaa ctggtggaga
    11041 agttaaccta aatagttcta atccaaataa atagttgcct gtctggaaat tatttcaatc
    11101 tcacttttaa aaacatttca tttgcccacc ctaaggtata actgacatac agtaaaatgc
    11161 acagacccta agtgaatatt ctcatgagtt tttgaaaaat atatagatcc atgtaaccaa
    11221 caccctaacc atataaagaa cattccatca tagttccctg gtgtcccttt ccactcaatt
    11281 gctcccctac cactttctat taccaaacag ttttgtccat ttttgaagtt catacaggtt
    11341 agtctctgtc tttttaatgc ttgtgtagta ttcatgtccc ctactggaca tacaggttat
    11401 atccaacaac acacatacac acgcaagcgc acacatacat atttgggctt actttttgta
    11461 ataatctgtg agatcttttt tcacattagt gaatattaat cccttggttg gctgcatttt
    11521 gttagtactt tttctcactg tcaaatcctc ttcattgttc caaaatagta tatcagttat
    11581 ttgtacattc aaaatgttat ggtatttaaa ttggaataaa caaaattatg ggtaactttt
    11641 ttctcacaaa tctgttgcct taatcttttt aaattatcat gtgcttcctt gtataatcca
    11701 aaagtgtttc aattttgaaa aacatgaaga atgatagcca tagcactagt actaaacatt
    11761 ttaaaacaat ttctgaatta cagaatcata aggagtctaa gatgaccatc tttgagaagg
    11821 aaaactttat tggacgccag tgggagatct ctgacgacta cccctccttg caagccatgg
    11881 gctggttcaa caacgaagtc ggctccatga agatacaaag tggggcgtaa gtacaaaaac
    11941 agggttggaa tatacttcaa agtaactcct gaggttgcat caatagttat gttttaatca
    12001 gatttcatac gtatcggtat agatgtcaca ttctagttct acataatttt gaatctcaat
    12061 ttctttatac caactaccac tttaggttgc agatttatct cccccagaca tgcctctatg
    12121 gaagaattta cgttgactac ttatacctgt tttgatgatt aaggctaatt aactagctat
    12181 agccatatta tgcttacaaa tagtgcctga cacatttagg atggctattt tttctaagcc
    12241 taaaagcatc tcataccatt gtgttgagta aagaggctca ggttttgggg tattaaccag
    12301 attcctaatt agttttaata atgaaatgta ctttgaattt cctagctggg tttgctacca
    12361 atatcctgga tatcgtgggt atcagtatat cttggaatgt gaccatcatg gaggagacta
    12421 taaacattgg agagagtggg gctctcatgc ccagacttcg cagatccaat cgattcgccg
    12481 aatccaacag tagctgatta aaagctccaa gtacgataat tcctcaagca tgagaccttg
    12541 ctaagcactc tagaataagt tttatgttct gctcacagac attgctttca aatgttagct
    12601 gctgaaatcc acaataaacg tcatttaaaa aaaaaaaact ttgtagactg aattaactac
    12661 catgcttcac ataaatcaca cctaagtgga tgagaatttt tttttttttt ttagttattt
    12721 tgctcttgtt gctcaggctg gagtgtaatg gcgctatctt ggttcaccac aaccttcgcc
    12781 tcccgggttc aagtgattct ctgcctcagc ctcccgagta gctgggatta caggcatgca
    12841 ccaccacacc tggctaattt tgtattttta gtagagacgg ggtttctcca tgttggtcag
    12901 gctggtctcg aactcccgac cttaggtgat ctgcccgcct cggcctcccg aagtgcggga
    12961 ttaccggcgt gagccaccac gcccggcctg tggatgagaa tttttgttgt tgttgagaca
    13021 gggtctcact gtcacccagg ctgaagtgca gtggtgcgat ctggcttact gcagcgtcat
    13081 tctcctgggc tcaagtgatc ctgcctcagc ctcctgagta gttgggacta caggtgcctg
    13141 ccactatgcc tggctaattt ttgtactttt tgtagagatg aggtctcact atgttgccca
    13201 ggctggtctc gaattcttgg gctcaagtga tccacccact gtggcttccc aaagtgctgg
    13261 gattacaggt gttgagccac tgcgcctgtc tggatgagaa ttttttaagt caagcttcca
    13321 taaaactcca cattctcttt tgtgtccttg caagtcactc accaggccaa ggacaattat
    13381 tccttatctc aaagaacaat aaagcatatg acctaaatgt tatcaatctc tatagcgact
    13441 gacacttttg gtaaatgttt ttatgtcctt tcctcccgtc tcctgctctt tctaataatg
    13501 ttgaagttgg cattgatttt cctttcacct tgtgacaaat cagtactaaa gaaacaggaa
    13561 gtttctccag tgtgtactgc cacatatttc aacataaagt tatgaataaa tccagaatct
    13621 tggcaactta acattctagt tgctcaactg cttagctcaa ttttgattta tttcaattgg
    13681 aagggcataa ggcttaatgt cctgcaaaaa ggcaggatag ctctggattt ttcaataagc
    13741 aagctaattc taagcactgt aaaaacctgt atgattaaaa aattttttta aaatcatagg
    13801 accatagtat actgaagact taaattcttc acatatttga ccctttggaa aaaaatcatt
    13861 atcaatgtca caaacttagt tttcggtttg tttttctttt tactttttat cagctgaatt
    13921 taagattagt cagtaaagac tttttaaaaa attaaagcac acaaaagata acaaacacct
    13981 cagaaacttt aaaatttttt attcaacaat gtacacttat tgtctctcaa tttgatctac
    14041 aaatttctca agtttttttt ctgataaaat aagtaaatct gggtatggtt gtagagtgtt
    14101 tgtaatttat atttttaaaa cactgaacat gatgaagaca tcaataaagg aagatcatca
    14161 cgtaaatgac acttcctcag aatccatgac atcagaaaca gctatagcaa atacctaagc
    14221 atttagcaaa agggaaaatt tctggtgact gttcttatat gtagaaaaga cctatatttt
    14281 tgactgggca aaacaaacat tgaaactttt ttttgagcgg ggggaacatc ctttaacata
    14341 actgtactcc acttattatc cattccccca gattaagagg taactcagct ccttagtgcc
    14401 tctgcacgag acagagaaat tacttcactc ctccagtagg ttctaagact gaacataagt
    14461 gaactactga cagatgcgga agaggaacca tagccatcta aaatgatgct tgctacactc
    14521 ctgcatttct gccttttaag gccatgcaat taatatgggt caccttttaa gtcttaactg
    14581 gataacttag tttttaactg ccactatcaa tgaagataca tatagaaggg ttttgctg
//

