LOCUS       NG_009824              10124 bp    DNA     linear   PRI 05-MAR-2010
DEFINITION  Homo sapiens crystallin, alpha B (CRYAB) on chromosome 11.
ACCESSION   NG_009824
VERSION     NG_009824.1  GI:223972692
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000907.6.
            
            Summary: Crystallins are separated into two classes:
            taxon-specific, or enzyme, and ubiquitous. The latter class
            constitutes the major proteins of vertebrate eye lens and maintains
            the transparency and refractive index of the lens. Since lens
            central fiber cells lose their nuclei during development, these
            crystallins are made and then retained throughout life, making them
            extremely stable proteins. Mammalian lens crystallins are divided
            into alpha, beta, and gamma families; beta and gamma crystallins
            are also considered as a superfamily. Alpha and beta families are
            further divided into acidic and basic groups. Seven protein regions
            exist in crystallins: four homologous motifs, a connecting peptide,
            and N- and C-terminal extensions. Alpha crystallins are composed of
            two gene products: alpha-A and alpha-B, for acidic and basic,
            respectively. Alpha crystallins can be induced by heat shock and
            are members of the small heat shock protein (sHSP also known as the
            HSP20) family. They act as molecular chaperones although they do
            not renature proteins and release them in the fashion of a true
            chaperone; instead they hold them in large soluble aggregates.
            Post-translational modifications decrease the ability to chaperone.
            These heterogeneous aggregates consist of 30-40 subunits; the
            alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two
            additional functions of alpha crystallins are an autokinase
            activity and participation in the intracellular architecture.
            Alpha-A and alpha-B gene products are differentially expressed;
            alpha-A is preferentially restricted to the lens and alpha-B is
            expressed widely in many tissues and organs. Elevated expression of
            alpha-B crystallin occurs in many neurological diseases; a missense
            mutation cosegregated in a family with a desmin-related myopathy.
            [provided by RefSeq].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10124             AP000907.6         8243-18366          c
FEATURES             Location/Qualifiers
     source          1..10124
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3-q23.1"
     STS             2634..3274
                     /standard_name="HSPB2_2418"
                     /db_xref="UniSTS:280769"
     STS             2656..2780
                     /standard_name="WI-17363"
                     /db_xref="UniSTS:71950"
     STS             2738..2860
                     /standard_name="STS-S67070"
                     /db_xref="UniSTS:32091"
     STS             2779..3952
                     /db_xref="UniSTS:486646"
     STS             2808..3945
                     /db_xref="UniSTS:482396"
     STS             4032..5056
                     /standard_name="PMC123035P1"
                     /db_xref="UniSTS:270427"
     STS             4272..4712
                     /standard_name="GDB:197835"
                     /db_xref="UniSTS:155957"
     STS             4845..4949
                     /standard_name="D11S3407"
                     /db_xref="UniSTS:152648"
     gene            5001..8124
                     /gene="CRYAB"
                     /gene_synonym="CRYA2; CTPP2; HSPB5"
                     /note="crystallin, alpha B"
                     /db_xref="GeneID:1410"
                     /db_xref="HGNC:2389"
                     /db_xref="MIM:123590"
     mRNA            join(5001..5226,6301..6423,7783..8124)
                     /gene="CRYAB"
                     /gene_synonym="CRYA2; CTPP2; HSPB5"
                     /product="crystallin, alpha B"
                     /transcript_id="NM_001885.1"
                     /db_xref="GI:4503056"
                     /db_xref="GeneID:1410"
                     /db_xref="HGNC:2389"
                     /db_xref="MIM:123590"
     exon            5001..5226
                     /gene="CRYAB"
                     /gene_synonym="CRYA2; CTPP2; HSPB5"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(5026..5226,6301..6423,7783..7986)
                     /gene="CRYAB"
                     /gene_synonym="CRYA2; CTPP2; HSPB5"
                     /note="heat-shock 20 kD like-protein; alpha crystallin B
                     chain; alpha B crystallin; alpha(B)-crystallin; heat shock
                     protein beta-5; rosenthal fiber component; renal carcinoma
                     antigen NY-REN-27; alpha-crystallin B chain"
                     /codon_start=1
                     /product="alpha-crystallin B chain"
                     /protein_id="NP_001876.1"
                     /db_xref="GI:4503057"
                     /db_xref="CCDS:CCDS8351.1"
                     /db_xref="GeneID:1410"
                     /db_xref="HGNC:2389"
                     /db_xref="MIM:123590"
     STS             5801..6310
                     /gene="CRYAB"
                     /gene_synonym="CRYA2; CTPP2; HSPB5"
                     /standard_name="CRYA2"
                     /db_xref="UniSTS:43082"
     exon            6301..6423
                     /gene="CRYAB"
                     /gene_synonym="CRYA2; CTPP2; HSPB5"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            7783..8124
                     /gene="CRYAB"
                     /gene_synonym="CRYA2; CTPP2; HSPB5"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     STS             7845..7990
                     /gene="CRYAB"
                     /gene_synonym="CRYA2; CTPP2; HSPB5"
                     /standard_name="D11S2244E"
                     /db_xref="UniSTS:32037"
     STS             7872..8051
                     /gene="CRYAB"
                     /gene_synonym="CRYA2; CTPP2; HSPB5"
                     /standard_name="RH17897"
                     /db_xref="UniSTS:18881"
     STS             7985..8109
                     /gene="CRYAB"
                     /gene_synonym="CRYA2; CTPP2; HSPB5"
                     /standard_name="SHGC-31520"
                     /db_xref="UniSTS:12481"
ORIGIN      
        1 acctcatatg cctaaagcag cattaataga agcctgaagt gataaacaag gatattgatt
       61 attccactga agtctgtacc agtcaatcca tgactggaat aataatttta ggtctagatg
      121 ttgaatttca agttacgttg tcaaaaggca gtatgttcaa aataaagtta tctgggtaat
      181 atgtgatgtg gaaagtgctg tatgatatgg ttgaaagaac aaggcatggc tgggtgtggt
      241 ggctcacgcc tgtaacccca atgtgttggg aggccgaggt gggcagattg cttgaggcca
      301 gaagttcaag actagcctgg acaacatggc gaaacccagt ctctacaaaa aattagccag
      361 gtgttgtggc gcatgcctgt agcctcagtt actcaggagg ttgaggtggg aggattgctt
      421 gagcccagga ggaggaggtt gcagtgaggg gagatgacac cactgtacac ccagcctcgg
      481 tgacagagag agactttgtc ttaaaaaaaa aaaaaagaac taggcatgtt tagctgggaa
      541 agggaagcct caggaagaca ggatggttat ctttaaatat cagaaggatt ttcagtgaaa
      601 aaaccattgt gtttgttttc cagagaagtt actgaaatgc agattttgat tcaacaaaag
      661 gaggaattta taacggttaa gtcagttaag accaaaaaga aaatggaagg ccaggtacag
      721 aggctcacac ctgtaatccc agtactgtgg cagaccaagg atagaggatt gcttgagtcc
      781 aggagttcaa gaccagcctg gacaacaagg cgagacctca tctccagaaa aagtaaaaaa
      841 ttagccaggc gtggtggcac acacctgtag tcccagctac tcaggaggct gaggcaggag
      901 gattgcttga gcaagggagg ttgaggctgc agtgagccat gatcatgcca ctgcactcca
      961 tcctgagcaa cagaacaaga ccctgtctaa aaaagaaaag aaagaacatg gaaacgacta
     1021 ccgtgagaag ttctaagttg tctgttattc agaatgtccc cgaataagtt gattaataac
     1081 tttaaaagca tttgaatgga gaggggattt ggactaaatc agaagttttc aaatttctta
     1141 tagctaggaa accctttcct ttaaataaag ctcagttaca aaacatatca atgtgaagct
     1201 attttggttg aagtctaagt agaatccttt tcttattatt tttcttctca actagattct
     1261 ggaaagttga caataaaagc taatagtttt tataatttat atttacaatg tatatccccc
     1321 aaggtgtatt acatgaggtt tgataaatat ttactgaatg aatgaatgaa cagttaaata
     1381 tgtcaaatgt tatttctctg gggcatgctt tcatttttaa tagacagcaa tcttttaacc
     1441 aaaagtcgaa ttcctcaagt gagttctgtt atcctggagg tccacagatc cctaaggggg
     1501 gtatgtgaat gggtcttaag agttgtggga acctattcaa attgtattgc caaatttggg
     1561 agcatatgta tttttctggt aagagcagct atagcttttg tcagattttc agaagggtct
     1621 ataactccca aaagttaaga aacaaccact taatttaatt caattcaatt taattttttt
     1681 gaggcagggt ctcactctgt cacccaggct ggagtgcagt ggcgcaatct cagctcactg
     1741 cagcttcaac ctccctagct catcctccca cctcagcctc ccaagtagct gggactacag
     1801 gcatgcacca ccatgcctgg ctaattttta tttttttgta gagacaaggt tgcactctat
     1861 tgcccaggct ggtctcttac tcttgggctc aagtgatcct cctgcctcgg cctcccaaag
     1921 tactgggatt acaggtgtga gctgctgcac ccagccaaga aacaactgct ttaatggaag
     1981 aattgtaggt atctaccaca gcctaatgaa atatgtattt ggaggcagga aggtcttttg
     2041 gacacttccc ccaaatcatg tagctggatg ttctcttgat tgcagagaat aactgagggg
     2101 acagacctca ggctttcctg aatacaccgt acccccagag gatgggaagg taatggggtt
     2161 ccgtgataat tggagaggct ttgtgtctgt gccctgtgta tgcatactca ggctctcaaa
     2221 atcagtgacc atttaagtgg acagacctta gtacatgaaa acaaagtatt cactccagga
     2281 ctttaggcaa ctctcaccag ccaaaaacca ttttcccagc ccctacccaa aaagggccag
     2341 acagtctgga gacccttgtt tttgtgtctc taatcaccag ctcagacagt gccctctggg
     2401 ctgtttggat ggcatatccc ttttccctcc caggatcact ctctcttttg ttgcattgtg
     2461 agaaaattat ggctaggaat ttgatctgga gccagagtca gcttccgggt gtgatctcag
     2521 catccaagtg cgagctcagg gtcctatgac gttgggcaca tcaaactgag gagctttttg
     2581 tctagctggc tgtgacctcc tccctccctc cccatcccag cttcccggcc acagaatagg
     2641 gagcagtaca aacaaggccc tgagatttgg gtttattcag ctccacccaa aactaaacca
     2701 aggctatgac atgtcccatg ggaccaaacc atacattgtg gaccatgcac ctttcccttc
     2761 ccccaaggat gctgctacct ctggagtggt gggcagctgc ccatatcacc ttgggaggta
     2821 gagagggatt tgctgggtgc tgggtctgtg gcaatcaggg ctcaactatg gctgcctcct
     2881 cctcttcctc tggatcagga ggcgcaggga gcagggagat gtagacctca ttgacctctg
     2941 tgtccaaatg tcggccaccc cgaggtgctt ccaggtttaa gatgccatca tgggagagag
     3001 cagctcggac tcgccagggg tcgacatcag caggcaggac ataggtgcgg cagaactctc
     3061 gggacacgaa gccgtggcgg tccaggcgct gggggtgccg ggcagacacc tccagcaggt
     3121 tatccacagt cctcacagtc acctcgtctg gggtaaagtg gctcacatcc agaaatgcct
     3181 ggaacttgcc ctcactgagc ctaagctcgg aggcccctgc cctgctgccc tccccagctg
     3241 gggcggcccg aggccggaca tagtagccat ggtagagtgt gggggtcagg atctcttctg
     3301 gcaggaggcc taaagggcag agagaaggca agaggcagga tgagggagga tgaggctggc
     3361 acaggggcga aatgggaaat ctggagagga gggattggga agagcaagag gggagtcagg
     3421 aggagtaggg aacgggaggg aggccacact gtagctagga ggagaaggca gctcggaaga
     3481 ggggaaagag aacggaaagg taagggagga ggaggaggag aaggaggagg agggggagga
     3541 ggaggaggca ccaaacggcc tgggtggata gaagggggac aaggaggcac acccaggccg
     3601 gcaaagagca ggtatcagca ctgcaagcac caagtgtgtc ttgaggtcag caggaatggg
     3661 aaagatctct gcttggaggg gatgaggggt agtctggggt ggggggtggc tggtcccagg
     3721 agatcagtta agcccagagt ggggtggagg ccagcaacgt tgggaggtca gcccagaatt
     3781 tcagggggtg ggggtggggg gcaagggggt ggtgtctgtg ccataccttc tccgaagcgc
     3841 tgctcaccca ggcggctcgg gttggcaaat tcgtactcgg cggtggccgg gtgggcatgt
     3901 ggcactgagc ggcccgacat ggctgcagat gcagcagaag ccctggtccg aggtgcagcc
     3961 ccaacaggcg cagcgcgacc cctccagctg cccggagagc cagggctcga taggaggtgg
     4021 gggcggggtc gacaccaccc aaaatagtgc cgagcctctt ggggggggag gggctgggag
     4081 tgggggccct gagtgagagc aacgagggtg tgaccagcgc cgcccggacc cctagtcccc
     4141 tcccccgcac actcttcagc tgtcgcaggg ggcctgagag gacagctgag ggtcctggct
     4201 gggaacgagc tggggagggg gagctggtgg tgcctggggc atgaagaggc ctcgctgaga
     4261 ccctcacaaa cggtttgcac gtttccacac ctcattttct cctcttcggt ggcaggcact
     4321 gtgcacccaa ttcctaaagc actcctggat ttaatgttct gagagccaca tagaacgaaa
     4381 gatgcaagaa atctgtttgc tcttttttca gggggtgggg tctttctgcc cagatgtggg
     4441 atcctctcct aaacccaggt caacccaggg cacgaggcag atggctggtg ctgacatgtt
     4501 gaccatcact gctctcttcc aaggactcac aaagagttaa tgtccctggg gctcagccta
     4561 ggaagattcc agtccctgcc caggcccaag atagttgctg gcctgattcc cctggcattc
     4621 aggactggaa aggaggagga ggggcacact acgccggctc ccatcctccc cccaccccgc
     4681 gtgcctgctt gggattcctg actctgtacc agcttcagag aacaggggtg ggggtgggtg
     4741 ccattgggtg tggacagaaa gctagtgaaa caagaccatg acaagtcact ggccggctca
     4801 gacgtgtttg tgtctctctt ttcttagctc agtgagtact gggtatgtgt cacattgcca
     4861 aatcccggat cacaagtctc catgaactgc tggtgagcta ggataataaa acccctgaca
     4921 tcaccattcc agaagcttca caagactgca tatataaggg gctggctgta gctgcagctg
     4981 aaggagctga ccagccagct gacccctcac actcacctag ccaccatgga catcgccatc
     5041 caccacccct ggatccgccg ccccttcttt cctttccact cccccagccg cctctttgac
     5101 cagttcttcg gagagcacct gttggagtct gatcttttcc cgacgtctac ttccctgagt
     5161 cccttctacc ttcggccacc ctccttcctg cgggcaccca gctggtttga cactggactc
     5221 tcagaggtga gtctccccac agctaggacg ggagagtcct tactggaacc tcctggaaac
     5281 ttctccatcc attttccttt cctaccctgc ctaaaccatt ttaggcacat gtgtgtccaa
     5341 atgtgaagaa aaatgaggag gttgctagtg ccttcctccc ccatcacctg tttctatttg
     5401 atagtcctct gtatcccatt tattacattt tttcatgcac tgtcaagttt atcctccgtc
     5461 ccctaacttc tctacaggat acccctttct ggtttggttc atgacaatct gcagggaaag
     5521 agctgccttc aaactccttt gcttatctct tccaacacct tggactcttg accgatttta
     5581 ccatctcagg tttcagagcc aggagagagc cctgcctcat cctgagctgt tcatccccat
     5641 gggtattttc tgcctttcta ttccctcttc tatgattttc tgggtttctc agggctacga
     5701 cagggcgctg gcctgggtcc aatcaagccc tacgaggaaa caatataggg acgcccattt
     5761 gtcctaagag ggtggaagaa cagggtgaac aaataaggtt gacagagctg tcacagataa
     5821 cactctggtt taaaaatatt caagtgtgag taaacaggag ctgagtgggc aagggctttg
     5881 gaaggacaag caggaccagc agaacattcc agattgggtg ggtggaaaac tggcaaagag
     5941 acctgagcca gaagaagagg cctttgtctc acagacaaac cacaaagcca ggcattggag
     6001 tcagagaggc agcagatgcc aggcttgcac ccatccttgc gactggtccc ctgggtgatc
     6061 tgtcttcttc tctgtccctg taaataaagt ttgggtctga tcaccatgag ccttaggtat
     6121 cactgtggtg gctccctgaa gcagacagct atgtttattt aaaaaggaga ttttttaagc
     6181 agagaagaga aggatgaatt acccggacag aaagcagctc tgcagaataa gacagcacct
     6241 gtgtaatcag tatttttgcc ctctttctcc catcccattc ccttaccttg ctatttctag
     6301 atgcgcctgg agaaggacag gttctctgtc aacctggatg tgaagcactt ctccccagag
     6361 gaactcaaag ttaaggtgtt gggagatgtg attgaggtgc atggaaaaca tgaagagcgc
     6421 caggtatgta gcttgttttt ttgttttctg ctcattcatt cagtgcatac tgtaatagtc
     6481 caggtagtgc tatcagcttt ggaggctggc tacattccag tcccaagcca taacagtcgg
     6541 gatcaggggt tacaaatcaa tgtctagaag actaagttag gatagacata ttgctgttgt
     6601 tactattatg gccagagatg tggcctttga tttgatcgcc ttagatggga tgatgggatg
     6661 ctgatgcccc atttaagcca gtggttctga atctgggcca cattagaatc accaggggaa
     6721 ctttcaaaaa acctaatgct cgggcatact ccagaccaat tagcatatgt gctgccgaag
     6781 cgagcactac tccagaccaa ttaaatcagc atttttaagg gtgggaccca ggcatcagca
     6841 atttttaagg taattctaat ctacagtcaa ggttgagaac cactgattag gtatagggct
     6901 gtcagacacc tagttgcttt gcataattac attaactaca ggtaccctaa aagcacttga
     6961 gttgtgactt ctcttttagc tgtgcaagaa tccgtgtctc ttctttagcc catcttaatg
     7021 ctgaactact tggtttgtct aaatttcaga gctgtgctca gtctttaatc ccctacagcc
     7081 catgtggtaa tcagttaacg agagcctgtt tggctacatg cttgagagtc agcaggcata
     7141 cgggttaagg tcatctactc tttgggggag ttctgacaaa tggaacagct tgttatgact
     7201 ttataagagg gctttaaaat tgcttctcac catttaacga tagctcagaa cctgtgcgtc
     7261 aaccagtaca gtttgtcctc agtaatgtcc tcaggctgtt tcaattttgc ttatatgatt
     7321 taggtttggg tcatagtctc cttggatgga gtcatttttt ttttttttta atttcagcag
     7381 cagtcctatt gttctggaac cttctgggac attcctgaag agtcaggaca atttcagggc
     7441 ttcctcaggg actcagattc taaatgagat tccaaattct gtaggcccag ccaacattga
     7501 tctaaacctt tgggaaatac ccctaaacat atctatgcct cagggtttga aaaacaatga
     7561 agtgttggac tgtttcagac ttctcagatt ctcactggta ggagtgacta cctaggcaat
     7621 ttcatcttag ctgcaaccct gaaacgaagc tctatttatt tttcctatgt tgtcatggca
     7681 tttggtctca cctaagggga aatcaggatg cctgagttct gggcaggtga taatagttcc
     7741 tgttcttatc tctctgcctc tttcctcatt cttttgggtt aggatgaaca tggtttcatc
     7801 tccagggagt tccacaggaa ataccggatc ccagctgatg tagaccctct caccattact
     7861 tcatccctgt catctgatgg ggtcctcact gtgaatggac caaggaaaca ggtctctggc
     7921 cctgagcgca ccattcccat cacccgtgaa gagaagcctg ctgtcaccgc agcccccaag
     7981 aaatagatgc cctttcttga attgcatttt ttaaaacaag aaagtttccc caccagtgaa
     8041 tgaaagtctt gtgactagtg ctgaagctta ttaatgctaa gggcaggccc aaattatcaa
     8101 gctaataaaa tatcattcag caacagataa ctgtcttgtg tttgaatatt ccacacactt
     8161 ttaaataaat atacagatac cacagatcta tttatgattg cattatgatt tagagggctc
     8221 caaggatttt agagtcagaa tgactgactt caccatttac tactggtata aatgtaggca
     8281 agttgcttaa cctttctggt cttcaggttt tccatttata acatgggtta ctgagttgta
     8341 cagaggaatt ataggaagta aattaaggag aagaagcagg aaaagccgct ggcagagttc
     8401 aaggaatatt agttactctc tctctgccct ctttgatttt agctctcagt ttaaaggact
     8461 ggaacacatc tgaatgaact ctggataacg ctacataaaa ggccttactg catctctaaa
     8521 attaattaca tcaccaggga agacatggtg accctaatac tgtttgacat tttcctattg
     8581 ataagcattg ccttaagctg atttacaagg gcaataaaca ggacttgggt gattatcacc
     8641 taacaagctc tgaggtatag gctaaatcag tggcccccaa cctttttggc accagggact
     8701 ggttttgtgg aagacaattt ttccatggcc ccgggggagc aggagatggt ttcaggatga
     8761 ttcaagcatt agattctcat aaggagtaca taacctagat ctctcacatg tgcagttcac
     8821 aataggattc atgctcatat gaaaatctaa tgccaccact gatgtgacag gaggtggagt
     8881 tcagcttcac tcacctccta ctgtgcagcc tggttcctaa taggccacgg gccagtacca
     8941 gtccatggcc tgggggttgg ggacccctgg tctaaattat ctagcaaaca cctactaacc
     9001 taaggccagg gaatatccaa ttcaatgtcc taccacgtaa tagttaagtt ttagaattac
     9061 aactaatagc caatcaataa gtggttctat tatttagctt aaagacatac cactgtacag
     9121 aaaaatcctc cccaaaacaa aaaacaaccc tccatttcat ttctgtgggt ctggacaaaa
     9181 cttctgattc acttgataaa cagcactgct gtaggtgatc tggtataaat gtttattgac
     9241 aactcttatt ttttctttag caacttctag ctaatttctg atttcatgca aaatcagaag
     9301 tcagtcagtt tggggactga ccagcgtttt gaaatattct acgtgaaaca attgcctaaa
     9361 tttttttatg acatagaggg aaacaacaca cactggagcc tatcggagga tggaaggtga
     9421 gagaagggtg agaatcagga aaaataccta atggttacta ggcttaatac ctgagttatg
     9481 aaatagtctg tataacaaac ccctatgaca tgcatttacc tatgtaagaa aataaaggaa
     9541 aaaaaagatc acaatgagaa tcactgagcc cctattagaa tgactaaaat gaaaaattga
     9601 ctataccaac taaaacaaaa aatataaata aataaattta aaacttaata aaaaaattca
     9661 tgatgcaggg gtgtggagct aggacaatat aaattgcaaa tctataccgg ttcaaaaatg
     9721 ctttctctta aaaaacaact tcctaatagt ctgaaatact gtgatctagc cagaagttta
     9781 cagccaattt ttgtggctgt gtagcagaca ctgttggttg cctaaccaac agctatttac
     9841 caccttcagc cttgccaaca gtatcccaga ttggtttagg tatacaccat gttcttccta
     9901 gccatgtgct tcagagaagt gaactcaagc tccagccata ggaggtctat cttgattagt
     9961 ccaaatcaag cagggaaatt ctcttcttga ttttcaagat tattcttgaa agggctatga
    10021 ctcaattatg gcaaatgaga caggagggaa gtctgttgga gatgcttcta gaaaaagttt
    10081 ctaaactaag aaaagatttc agaaagattc agagagagag agag
//

