LOCUS       NG_008029              12307 bp    DNA     linear   PRI 10-NOV-2011
DEFINITION  Homo sapiens cholinergic receptor, nicotinic, epsilon (CHRNE); and
            chromosome 17 open reading frame 107 (C17orf107), RefSeqGene on
            chromosome 17.
ACCESSION   NG_008029
VERSION     NG_008029.2  GI:324120890
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC233723.2.
            This sequence is a reference standard in the RefSeqGene project.
            On Feb 26, 2011 this sequence version replaced gi:190358478.
            
            Summary: Acetylcholine receptors at mature mammalian neuromuscular
            junctions are pentameric protein complexes composed of four
            subunits in the ratio of two alpha subunits to one beta, one
            epsilon, and one delta subunit. The acetylcholine receptor changes
            subunit composition shortly after birth when the epsilon subunit
            replaces the gamma subunit seen in embryonic receptors. Mutations
            in the epsilon subunit are associated with congenital myasthenic
            syndrome. [provided by RefSeq, Sep 2009].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12307             AC233723.2         27596-39902
FEATURES             Location/Qualifiers
     source          1..12307
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            5002..10307
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /note="cholinergic receptor, nicotinic, epsilon"
                     /db_xref="GeneID:1145"
                     /db_xref="HGNC:1966"
                     /db_xref="MIM:100725"
     mRNA            join(5002..5058,5313..5455,5582..5626,5750..5859,
                     5989..6144,6451..6551,6886..7086,7169..7283,8494..8608,
                     8692..8878,8969..9075,9185..10307)
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /product="cholinergic receptor, nicotinic, epsilon"
                     /transcript_id="NM_000080.3"
                     /db_xref="GI:294862246"
                     /db_xref="GeneID:1145"
                     /db_xref="HGNC:1966"
                     /db_xref="MIM:100725"
     exon            5002..5058
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(5013..5058,5313..5455,5582..5626,5750..5859,
                     5989..6144,6451..6551,6886..7086,7169..7283,8494..8608,
                     8692..8878,8969..9075,9185..9340)
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /note="cholinergic receptor, nicotinic, epsilon
                     polypeptide; acetylcholine receptor subunit epsilon; AchR
                     epsilon subunit"
                     /codon_start=1
                     /product="acetylcholine receptor subunit epsilon
                     precursor"
                     /protein_id="NP_000071.1"
                     /db_xref="GI:4557463"
                     /db_xref="CCDS:CCDS11058.1"
                     /db_xref="GeneID:1145"
                     /db_xref="HGNC:1966"
                     /db_xref="MIM:100725"
     gene            complement(5144..8423)
                     /gene="C17orf107"
                     /note="chromosome 17 open reading frame 107"
                     /db_xref="GeneID:100130311"
                     /db_xref="HGNC:37238"
     mRNA            complement(join(5144..7839,7931..8140,8248..8423))
                     /gene="C17orf107"
                     /product="chromosome 17 open reading frame 107"
                     /transcript_id="NM_001145536.1"
                     /db_xref="GI:224493722"
                     /db_xref="GeneID:100130311"
                     /db_xref="HGNC:37238"
     exon            complement(5144..7839)
                     /gene="C17orf107"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     exon            5313..5455
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            5582..5626
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     exon            5750..5859
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     exon            5989..6144
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     exon            6451..6551
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     STS             6464..6913
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /standard_name="CHRNE"
                     /db_xref="UniSTS:510364"
     exon            6886..7086
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=7
     exon            7169..7283
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=8
     CDS             complement(join(7543..7839,7931..8140,8248..8313))
                     /gene="C17orf107"
                     /codon_start=1
                     /product="uncharacterized protein C17orf107"
                     /protein_id="NP_001139008.1"
                     /db_xref="GI:224493723"
                     /db_xref="CCDS:CCDS45591.1"
                     /db_xref="GeneID:100130311"
                     /db_xref="HGNC:37238"
     exon            complement(7931..8140)
                     /gene="C17orf107"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            complement(8248..8423)
                     /gene="C17orf107"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     exon            8494..8608
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=9
     exon            8692..8878
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=10
     exon            8969..9075
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=11
     exon            9185..10307
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=12
     STS             9416..9574
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /standard_name="SHGC-11989"
                     /db_xref="UniSTS:28629"
     STS             9555..9838
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /standard_name="WI-19144"
                     /db_xref="UniSTS:58046"
     gene            complement(10015..>12307)
                     /gene="MINK1"
                     /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2;
                     ZC3"
                     /note="misshapen-like kinase 1"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:17565"
                     /db_xref="MIM:609426"
     mRNA            complement(join(10015..10872,11263..11402,11488..11647,
                     11734..11883,11973..12073,12244..>12307))
                     /gene="MINK1"
                     /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2;
                     ZC3"
                     /product="misshapen-like kinase 1, transcript variant 1"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_015716.4"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_015716.4"
                     /db_xref="GI:259089410"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:17565"
                     /db_xref="MIM:609426"
     mRNA            complement(join(10015..10872,11263..11402,11488..11647,
                     11734..11883,11973..12073,12244..>12307))
                     /gene="MINK1"
                     /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2;
                     ZC3"
                     /product="misshapen-like kinase 1, transcript variant 2"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_170663.4"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_170663.4"
                     /db_xref="GI:259089413"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:17565"
                     /db_xref="MIM:609426"
     mRNA            complement(join(10015..10872,11263..11402,11488..11647,
                     11734..11883,11973..12073,12244..>12307))
                     /gene="MINK1"
                     /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2;
                     ZC3"
                     /product="misshapen-like kinase 1, transcript variant 3"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_153827.4"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_153827.4"
                     /db_xref="GI:259089412"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:17565"
                     /db_xref="MIM:609426"
     mRNA            complement(join(10015..10872,11263..11402,11488..11647,
                     11734..11883,11973..12073,12244..>12307))
                     /gene="MINK1"
                     /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2;
                     ZC3"
                     /product="misshapen-like kinase 1, transcript variant 4"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_001024937.3"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_001024937.3"
                     /db_xref="GI:259089411"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:17565"
                     /db_xref="MIM:609426"
     STS             10047..10272
                     /gene="CHRNE"
                     /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS"
                     /standard_name="RH76075"
                     /db_xref="UniSTS:83674"
     CDS             complement(join(10789..10872,11263..11402,11488..11647,
                     11734..11883,11973..12073,12244..>12307))
                     /gene="MINK1"
                     /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2;
                     ZC3"
                     /EC_number="2.7.11.1"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_056531.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 1 is encoded by transcript variant 1;
                     misshapen/NIK-related kinase; GCK family kinase MINK;
                     serine/threonine protein kinase; MEKKK 6; MEK kinase
                     kinase 6; MAPK/ERK kinase kinase kinase 6;
                     mitogen-activated protein kinase kinase kinase kinase 6"
                     /codon_start=1
                     /product="misshapen-like kinase 1 isoform 1"
                     /protein_id="NP_056531.1"
                     /db_xref="GI:7657335"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:17565"
                     /db_xref="MIM:609426"
     CDS             complement(join(10789..10872,11263..11402,11488..11647,
                     11734..11883,11973..12073,12244..>12307))
                     /gene="MINK1"
                     /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2;
                     ZC3"
                     /EC_number="2.7.11.1"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_733763.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 2 is encoded by transcript variant 2;
                     misshapen/NIK-related kinase; GCK family kinase MINK;
                     serine/threonine protein kinase; MEKKK 6; MEK kinase
                     kinase 6; MAPK/ERK kinase kinase kinase 6;
                     mitogen-activated protein kinase kinase kinase kinase 6"
                     /codon_start=1
                     /product="misshapen-like kinase 1 isoform 2"
                     /protein_id="NP_733763.1"
                     /db_xref="GI:24850117"
                     /db_xref="CCDS:CCDS45589.1"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:17565"
                     /db_xref="MIM:609426"
     CDS             complement(join(10789..10872,11263..11402,11488..11647,
                     11734..11883,11973..12073,12244..>12307))
                     /gene="MINK1"
                     /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2;
                     ZC3"
                     /EC_number="2.7.11.1"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_722549.2"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 3 is encoded by transcript variant 3;
                     misshapen/NIK-related kinase; GCK family kinase MINK;
                     serine/threonine protein kinase; MEKKK 6; MEK kinase
                     kinase 6; MAPK/ERK kinase kinase kinase 6;
                     mitogen-activated protein kinase kinase kinase kinase 6"
                     /codon_start=1
                     /product="misshapen-like kinase 1 isoform 3"
                     /protein_id="NP_722549.2"
                     /db_xref="GI:27436917"
                     /db_xref="CCDS:CCDS45588.1"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:17565"
                     /db_xref="MIM:609426"
     CDS             complement(join(10789..10872,11263..11402,11488..11647,
                     11734..11883,11973..12073,12244..>12307))
                     /gene="MINK1"
                     /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2;
                     ZC3"
                     /EC_number="2.7.11.1"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_001020108.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform 4 is encoded by transcript variant 4;
                     misshapen/NIK-related kinase; GCK family kinase MINK;
                     serine/threonine protein kinase; MEKKK 6; MEK kinase
                     kinase 6; MAPK/ERK kinase kinase kinase 6;
                     mitogen-activated protein kinase kinase kinase kinase 6"
                     /codon_start=1
                     /product="misshapen-like kinase 1 isoform 4"
                     /protein_id="NP_001020108.1"
                     /db_xref="GI:68161546"
                     /db_xref="CCDS:CCDS45590.1"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:17565"
                     /db_xref="MIM:609426"
ORIGIN      
        1 gcctcagcct cccgagtagc tgggattaca ggtgtaatcc cctggctaat tttttgtatc
       61 tttagtagag acggggtttc accatgttga tcaggctggt cccaaactac tgacctcgtg
      121 atccgcccgc ctcggcctcc caaagtgctg ggattactgg tgtgagccac cgtgcccgac
      181 taagttttct atttttagta gagacagggt ttcaccatgt gggtcaggct ggtcttgaac
      241 tcctgatctc aagtgatcca cctgccttgg ctgcccaaag tgctgggatt acaggcacga
      301 gccacctcac ccagcccact attgcatttt ctatgttgtg gggtgtgtgt gtgatgtatt
      361 gtttatacat gatgtagttg tggtgcttaa gttgaggatt tagcccatca tttggagaat
      421 ggatggaaat cagacctgag tgaaactact tagagcaggg gacactggac tctgggctga
      481 gagtgttttt tttttttttt tttttttttg agactgagtc ttgctctgtc accaggctgg
      541 agtgcagtgg cgtgatcttg gctcactgca agctccgcct cccgggttca cgccattctc
      601 ctgcctcagc ctcccgagta gctgggacta caggcgcccg ccaccatgcc cggctaattt
      661 ttttttttta atttttagta gacacggggt ttcaccatgc tagccaggat ggtcttgatc
      721 tcctgacctc gtgatccgcc cgcctcggcc tcccgaagtg cagggattac aggcgtgagc
      781 ccccgcgccc ggcccggagt gttttcttga aggacccttg ccataatcac tttttttttt
      841 aattccccca atcatttatc ctttaagtta ccaaccatgc aattacactc ttaagttttt
      901 tttaacatgt acaatgaaat tattattgac tacagtcact ctgttgtgct atcaaatagt
      961 aggtcttatt ctattttttt tgtacccatt aaccatcccc accatccacc tacctgccca
     1021 ctacccttcc cagcctctgg taaccatcct tctactctct atgtccatga ggtcaattgt
     1081 tttgattttt aactcccaca aataagtgag aacatgcaat gattgtcttt ctgtgcctgg
     1141 cttatttcac ctaacataat gatctccagt tccattcatg ttgttgcaaa tgacaggatc
     1201 tcatcctttt ttatgggtga atggtgctcc attgtgtata tgtaccacat ttgctttatc
     1261 cattcatctg tgtttttctt ttttcttttt tttttaaaca gttttctctc ttgtttccca
     1321 ggctaggatg cagtggcatg atcttggctc accattcatc tgttttttaa aattttattt
     1381 atttatttac agatgaggtc tcactatatt gcccaggctg gtcttgaact cccaggctca
     1441 agcaattctc ctacctcagc ctcccagtga tgaccaatga tgctgagcac gttttcttat
     1501 acctgtttgg catttgtgtg tcttattttg agaagcgtct attcaaatct tctgccctct
     1561 ttttgatcag attattagat tttttttctc ataatcactt tttgaagcaa gatttcaagt
     1621 ttgaatcctg ctggggagga tagagtgaat ttatattaac tgtattaatt tatgtatatt
     1681 tcatatattt gtatatattt cagctctagc agtgagaatg gcatcctggc aggccgtttt
     1741 gggagctaaa catataggag aagtgggctg ggttgctaga gggtgaatta ccagacatgt
     1801 ggtgtcaggg cctgccacac ccactatcca tcctaaacaa ggcagtctta ggccaacccc
     1861 atgatccttc ttcagtgttg gcaccccaag ccctcagagc atcaggcagt agcaacggga
     1921 acaaaagtgc tgcctctgca gagagaagcc aagaagttgg tctggggcta agaccatggt
     1981 gaaatgatgc acaggtgacg agaaagcaga aactacacag tagaaagggg acatgcaaag
     2041 tagggggaat gggcagtgct gacgaagtga gaggagcaga gagcggacag agcggcagag
     2101 acagatcagg agacaggctc tggagctgcc ttggcctctg acactggtct agtaagttcc
     2161 agtccatgtg caagactaca ggaaacctag gagaaacttc atttttttgt tttttgagat
     2221 ggagtctcac tctgtcaccc gggctggagt gcagtggcac gatctcggct cactgcaacc
     2281 tccgtctccc aggttcaagt gattctcctg cctcagcctc ccgagtagct gggattacag
     2341 gtgccagcca ccacacccag ctaatttttg tgtttttagt agagatgggg tttcaccatg
     2401 ttggccagac tggtctcgaa ctcttgacct caggtggtcc acctgccttg gcctcccaaa
     2461 gtgctgggat tacaggtgtt gagccaccgc atccagccgg aaacttcatt tttttgagat
     2521 agggtctcgc ttgtcaccca ggctggagtg tagtgtgatc gtagctcact gtgtccttga
     2581 tctcttaggg tcaagcaatc ctcccgcctc agcctcctaa gtagctggga ctacaggcat
     2641 gcaccatgat gcctggctaa tattttttgt tgttgtttat ttatttttgt agagatgggg
     2701 ggtctcactg tgttgcccag gctggtcttg aactcctggg ctcaagtgat gctccagcct
     2761 cagcctccca aatagttagg attacaggca tgagccactg tgcctggcca aaaccttgct
     2821 tttctgacag atctgattca ccctagctac agattctata gcacctgttt atttttatgc
     2881 ttctcatagt ctggcatcac tggctgttga taggtctctg tcattagatg ataactcctt
     2941 gaggcttgtt ttatccatct caataaccgt agcactcggc cctgtaaggg ggaactttgt
     3001 aggtgtccac tgatgtttga ataaatattt gcatttatca caattcttgt cccaagcctt
     3061 gacgcggaag ctctggaata agcagcagca cagatttgag acttagtcca tgtaccagcc
     3121 acatgcaaag aggtaagctg ggtcaaagag acccagaaag ggagtctgaa atggaaatcg
     3181 tggggttgat aaggcagcag tggaaacaga ggctttacac aagtgtggga aatggactag
     3241 gaggacactc tgttatttga tgtgtcctcg cttgtaacat ggaggtgatt atgacctacc
     3301 tcataggtgg gggaaggaga cccaaaggtg atggacccga aagtgttttg tgaagggtaa
     3361 aataaacaca ggtgtgcgag atcaatagag ttgattgata agtctcatgc attattgcca
     3421 atctacttgt gtgaccctgg atcccgacct tagcatcccc tttcatgtat tcaggacagt
     3481 gatcattgct ttgctggact gctgtgagga aatgagatgt aagcagaaaa tatgcttagg
     3541 ccagcccctc ctacctcacg aggaacacct ggacagtttc ctaaaaatac agattcctgg
     3601 caccctagtc ccgaaatcat aattctctgg gaatggagcc taggaatctg aatttaaaat
     3661 aagcacccct ccaggtgatt agaatggttc aagaaggctt taaaaaacac tgaggccggg
     3721 cgtggtggct cacacctgta atcctaaccc tttgggaagc tgaggcagga ggatcgcttt
     3781 agcccaggag tttgagagcc gcagtgaact atggtggtgc cactgtactc ctgtctgggt
     3841 gacagagtga gatcctgtcc ccccaccccc tgcaaaaaac aaaaaacaaa aaaagaaaca
     3901 gaaaaacaaa aaacatcgag gctgggcgcg gtggctcacg cctataatcc cagcactttg
     3961 ggaggcccag gtaggtggct cacgaggtca ggagatcgag accatcctgg ctaacatggt
     4021 gaaaccccat ctctactaaa aaatacaaaa attagccggg catggtggca tgcgcctgta
     4081 gtcccagcta ctccagaggt tgaggcagga gaatcgcttg aacccgggag gcggaggttg
     4141 cagtgagccg agatcatgcc actgcactcc agtctgggcg ccagagcgag acttggtctc
     4201 aaaaaaattt tttttaaaaa ggaacatcaa aaggatctat taaggtgtca tcaggtgtgt
     4261 gtgtatgtgt gcacgtgtgt gtttaggaga gtaggatggg aagacggtac tatcatctgt
     4321 gaccacaagg tggcagcagg gatagacaag gagaaacaag tctcccaccc agaggggctg
     4381 ggcatgggca aacctggcga tcaggttgtg gaaggaggtg ggtcctttac atgatctcct
     4441 ttgctagatg gaatctctgt accgcagggc taatcccctg tgaccacctg tctctttatc
     4501 aggtctttat ggagactgtt ttttgccact ctgtcggcaa gaaaggcatt gtgagcttgg
     4561 gtggtgatag tgtgtgttcc acatgggtga gaatgggagg caaggggtgt gtcacatccc
     4621 cagatgtgtt catcagtcag ggtcacctac acagggcagc ttactcaaag gacaacagtg
     4681 cctgctgaaa gcagtgtctc ccaccccctg ctactagaat tgtggttgca ggtgcctctc
     4741 aggagacgcc cacatctgtg gctggggagt tggccaaata ccaggcaaag gacgctgggc
     4801 tggggcgggg caggggcagg aaacacagga tggggcagct gcctctggaa gcagccaaaa
     4861 tgtccccagc tgcagcaggg gtgagcagag gattaggtga cagtccccta acagcccgga
     4921 actaacaccc tcctccccct cacacaggca ccctggcatg ccccctccaa gcctgccaga
     4981 gctcagaata accctgagaa ccacgcagca ggatggcaag ggctccgctt ggggtcctgc
     5041 tcctcttggg gcttctcggt acggacaggg gctagagggg caattggaca cacacagata
     5101 ctgacatgaa gggactggga agacaaagac agagaccaag atggagactt agacacagta
     5161 tttcgttccc aggcacagca taattggttt aggagacaga tactgatagt acacagcctc
     5221 agaggcctgt gaggacccag gggaggcaga ggggagagag gtgctccagc ctcttcattg
     5281 ccaatgaccc ttccttcttg accccatcgc aggcaggggt gtggggaaga acgaggaact
     5341 gcgtctttat caccatctct tcaacaacta tgacccagga agccggccag tgcgggagcc
     5401 tgaggatact gtcaccatca gcctcaaggt caccctgacg aatctcatct cactggtaag
     5461 ctacccccac cctcatctta agccaaaaat cccacttctg gccccaaccg ctgagctctg
     5521 tcctaaagct cacttctggc cctgaaatct cacttcaatc atccccatct cccatctgca
     5581 gaatgaaaaa gaggagactc tcaccactag cgtctggatt ggaatcgtga gtcaaatctg
     5641 gggaatggtg tgaggtcttg tccagggcac cccttttccc ccaaacccct cccaggcagc
     5701 gccaggtggg agatgcaggg cacgcggcct tccatccccc accccttagg attggcagga
     5761 ttaccgactc aactacagca aggacgactt tgggggtata gaaaccctgc gagtcccttc
     5821 agaactcgtg tggctgccag agattgtgct ggaaaacaag tgagaaccgg gccagacgcc
     5881 aggctggagg gaagccggcc tggggtgcgg gctggacttg gttggggaag ggggtactct
     5941 gagagggtgc agacctgtgc aaaaagctcg gtttccccga gcccacagta ttgatggcca
     6001 gttcggagtg gcctacgacg ccaacgtgct cgtctacgag ggcggctccg tgacgtggct
     6061 gcctccggcc atctaccgca gcgtctgcgc agtggaggtc acctacttcc ccttcgattg
     6121 gcagaactgt tcgcttattt tccggtggga agagctactc cgaggcccgg acgattattg
     6181 ttgggggggg gccttatggg gcggggccaa ccgggaagca ccgccctcgg ggcggggctt
     6241 cgcgctggag gcggagccag gcgtaggcac tgggtgggac gctccagcgc ggccggaggt
     6301 acagatggga acagaggcgt gcgggctggg cttgggtgaa ggggtgggct tgggatcgcg
     6361 gccccgctag atcccagctt ccagggctgg gcctgaggcc ggggcccagg tcagagcttc
     6421 tggggtgggc tcccggccct ggctccgcag ctctcagacg tacaatgccg aagaggtgga
     6481 gttcactttt gccgtagaca acgacggcaa gaccatcaac aagatcgaca tcgacacaga
     6541 ggcctatact ggtgaagccc ctgcctgctc agaaaaaccc gcttctagac ggggtccaga
     6601 gaggggactt ccacggtggg cttgccccgg accaacgaca ctggaggatg acttccacaa
     6661 ctgggtttag cttacccctg tcctgaaatc attctcgatt gttactctag tcctgccttc
     6721 tggctttcca taccctcaac gagaatgccc ttttctgtcc gtaattgccc ccatcctgac
     6781 ggcccatgac cctggtgcag acagccgcag cctcctcttc agcccgctgt cagctcggcg
     6841 ggcgccccgc tctgacagcc agctgaccgt gcccccgtcc cgcagagaac ggcgagtggg
     6901 ccatcgactt ctgcccgggg gtgatccgcc gccaccacgg tggcgccacc gacggcccag
     6961 gggagactga cgtcatctac tcgctcatca tccgccggaa gccgctcttc tacgtcatta
     7021 acatcatcgt gccctgtgtg ctcatctcgg gcctggtgct gctcgcctac ttcctgccgg
     7081 cgcagggtaa gcagtggccc cgaacctacc cccaaacccg ggctcgctcc cgggaggcgg
     7141 ggcccgctct cactggctct ccctccagcc ggcggccaga aatgcacggt ctccatcaac
     7201 gtcctgctcg cccagaccgt cttcttgttc ctcattgccc agaaaatccc agagacttct
     7261 ctgagcgtgc cgctcctggg caggtgaagc cggagccccc gcgggggtgt ggccagtgtg
     7321 aagggtgggg gcgtggccaa aacccagaga ccccgggaaa agctctggct gtctcgcccc
     7381 gccctgggct ttattcggac gctgggtggg gctggtacgg ggatggagtc cctggtccgc
     7441 cgtcctcctc actgctgctg gacgtcacct ggaggtctcc cgagtagctc tcttggggga
     7501 cagtccggct cagtgcctcc ctagccccgc cgcctctggc ccctaactca ccccgtgtcc
     7561 tgagctcacc ggttctccgg ggattccgag gcctagctgc tgttgcgact gtcgcaggaa
     7621 tgaggcagac ccctgcagac cccgtccaca caggcatagc catgctccct ggactaggag
     7681 ccgggcgctg gcgcccaccg cagccccagc ttgccgaacc ccctgccctg cggcttgggc
     7741 tacccggctc agcgctgcac ccggatccct gccgtctggg gctgggcccg cgctgccgtc
     7801 tagtcgccgc gcctcctgct gcagccacag ggctgagatc tgcattgggg gcacaggggt
     7861 tagcggggag gcagaggtcc ttgttcccgc tacccgatcg ccgcgtatcc taagcccccc
     7921 agtaccccac ctctaacaag gtggtgccga agctcacgag gctggctgtg gcttctctca
     7981 acaccagccc cagggtgggc ttcggggcag gcagcatccc ctgcatcttc ggttcgggtg
     8041 gctccaggga cttcagctct ctgaacctct gctccagata ttcatgggct gcggccacgg
     8101 agagttccag ggaagacaga agcgggggct ggagggccac ctggagaagg agcagagcag
     8161 tagagtagca gggcaggggt cacaggggcg aacaggagac ctacccagaa ggtctcgagg
     8221 tgcagccctt ggcgggcgta gcctcacctc ggtggagctg tggaagtggt agatccacat
     8281 cagggtgtcc agggagctgg gggtcccctt catggccgcc acaagtggta ggacaggaga
     8341 agggctgggg gacgcgtctg tcgtcgtgta gggggcgcag ctggagggcg taaccagccc
     8401 gtaccaggag aagccgtgtt tgtgaggtca gcgcgcggcg ccttcggtag ctgggaggag
     8461 gaacggtgat gtcatgcctt ccgggctcct caggttcctt attttcgtca tggtggtcgc
     8521 cacgctcatt gtcatgaatt gcgtcatcgt gctcaacgtg tcccagcgga cgcccaccac
     8581 ccacgccatg tccccgcggc tgcgccacgt aagcgcggag ggggcggtgc agcccgggtc
     8641 ggggtggggc ttcgtactaa cctcgtcccc taagccccgc ccctgcccca ggttctcctg
     8701 gagctgctgc cgcgcctcct gggctccccg ccgccgcccg aggccccccg ggccgcctcg
     8761 cccccaaggc gggcgtcgtc ggtgggctta ttgctccgcg cggaggagct gatactgaaa
     8821 aagccacgga gcgagctcgt gtttgagggg cagaggcacc ggcaggggac ctggacgggt
     8881 gagcacagtg gccctggccc ggggggccgc gcggggtgcc tgccaggggg gaggctccta
     8941 aggcccaccc cggtgttttc cccgccagct gccttctgcc agagcctggg cgccgccgcc
     9001 cccgaggtcc gctgctgtgt ggatgccgtg aacttcgtgg ccgagagcac gagagatcag
     9061 gaggccaccg gcgaggtggg acaggagcca gaggcgggtg gagcgaggca gaggcccacc
     9121 actgtctccc atgccgctgg ctcctgcagc tgcctcttta ctgactgtgc cgacccttcc
     9181 ccaggaagtg tccgactggg tgcgcatggg gaatgccctt gacaacatct gcttctgggc
     9241 cgctctggtg ctcttcagcg tgggctccag cctcatcttc ctcggggcct acttcaaccg
     9301 agtgcctgat ctcccctacg cgccgtgtat ccagccttag ctcgcaccga cttcaatttc
     9361 ccacccatct ccagtaggaa attgattttg aaaaagtagg ctgccgccac cacggcatta
     9421 tgatcccttc cccctgctga tcaatctgca gtttgtgaac ttcacaagaa tggtgtgtgc
     9481 ccgttccctg gcgtgtgtag gcctggccgc agtccagggg tcagcaggag gaaagggttc
     9541 acataggctc tcaggtgcca gtcttccaga aagcaaggac tgcccttcat tcagccttgc
     9601 tgacctccca gcctttctaa ggctcagccc cacgggactc tggtggctgc cagcttgtga
     9661 gctatctatc tatattcatt tcatagccaa acaggagacc cctttgcagg acttgcacac
     9721 agggaggctg tagccaggaa accctcttct tccctggtct ggctctgctg gagcgggtgg
     9781 gaaccaaaca ccttcagtgc tggtggccct caggcccaca ggtttaaggc tgaggctgcc
     9841 ctgacccttc cacagtcatt tcttctaggt tttcttggcc cagcactgcc catcccaccc
     9901 catgaggctc actcattgca gatcccagcc caccctgccc ctttcttccc caccctggag
     9961 gctctctctg cctagtctac agtactgaca gaaagcaagg acatgcggcc tgcatggtgg
    10021 gagctggttg aattgtcttt attaacaaac aggatatcca aggccactac attgaggagg
    10081 ggtggggggg gagggagaag ggttacttgc tgctcacact atatacagat gcaagcaagg
    10141 ggcgtggaga gtgagggctc cctgctccct ccctccaccg gggaagggca tgggctagaa
    10201 gaggagaggg gggtcgggaa tggggggaat gttttggctg gcggggtccc ccctccattc
    10261 cctggagttt gggggaaggg gaatcattaa agtgctttca gaaaatgaag aaatggtccc
    10321 tgcccctgga gtggctggtg accccccaaa aatctagggc ccagtgaccc cccccagggt
    10381 ctggtacatt caagggggga gccggctccc ctgacgtgca aataaagggg tccagggccc
    10441 tgcccagtca gcagcagtgg ggtaaggggt tcaagcccca agcactctcc tctcaaatgg
    10501 agaaaagggg ggaggggcta ggcccactca attcctggga aggggaagct gtgtccctcc
    10561 ccagaagctg gggacaggca cagttttggg aagaggacat gttggggaag aggatggtca
    10621 cgtgatcacg aaagcatcag gggtcagagg tcacgttccc agcaggctcc agtgaaatca
    10681 aaccagtaaa agcaaaagcc cagggagggg aaagaggggc ggcccgggaa gcctggctgc
    10741 agggggagag ctgggtccag tgtgggacag ccccagccca gggccccgtc accagttcat
    10801 gatgcagtta cggttcagag tcatgaagta aacttggctg ctgcccccag agcggactga
    10861 ggcaaaaaac acctgggtgg ggcaggagaa gaagtcacca agggctgagg ttgggggggt
    10921 gtctcaactg ggagagggaa agaagggaag aaggggtggc agaagagttg agggagacac
    10981 agagactgca ggaggagact cacagtgccc ctcacccgga ggaaaggcag gctgggatgt
    11041 taggggagag ggtgcaccac tcgccccctg ggggccagct gggaagtcct cggaatctga
    11101 agggagcgca gggcagtggt agtggctgac tgccctctga gctcccagag gggcccgctt
    11161 tcaggaagcc accaccacca tcctctcccc agaactctgc ccaggggcct agggtcatgg
    11221 cagccgggac agcagggctt tcagagggaa ggagcctccc accttgtcat tccgctcaca
    11281 caggaacttg agcctctgag ctcgtttgtg catgaagacc ccgtcgaggt ggcccgtctc
    11341 cacagagcgg atctcaatgg ctttctcacc ccagcccatt atctggttgg agcagatgta
    11401 ggctgtgggg aacaggtgag gggctgagca ggctgcaccc cggggccacc tcggggcatg
    11461 tggctgggag ggcggcagct cactcaccca cagaagtagg catctccccc cactgcagca
    11521 ccacatcctt aatgatgcgc ccgtacgtgt tgacgtagac accctcgtcc tcgtagcaca
    11581 gcagcatctc catgccgtcg gtgttgggga ggaagatgat ggcatggggc gtgatctggc
    11641 tctggatctg gggagaagga gggggactag agtctccgtg tctggtgccc agactgggcc
    11701 atcccactcc cccagcagcc ccgccaagct cacgtgcaca gggatgtaga tgtcatagct
    11761 gttccccgag tcgacatcca cagcatggaa gccagcactg gagccataga tgaccttgag
    11821 ccgctgcccc tcctctactg tcaggtcgac cagcagaggg cggtggggga ggtcggcaaa
    11881 ggactgcaga gaaccggagg agaggagggc tcaggggcac ggggagaggc gctgggactc
    11941 cagatggtgt tagggaccga ggctgggatt accttgaagg ccatgaattt gtggtagggt
    12001 ttgggggccc aggcatacac ctccacggag ctcttgaggg cgatgaccag gaacttaatc
    12061 cgctcgtatt tcactggggg cgggagagaa gagggatgct gagacttccc ttcttgcgcc
    12121 acgggcgcct ccccgtggtc tgtcactaca ctgccccacc caggccccaa gtccctggct
    12181 cccagatcca tttctctctt catgaacaag tatgcgctgg ccactctgtt gggacatcct
    12241 caccaacacg gtagtgcccg cagccctcca tgtcccccac ggtggtccag ccctgcttct
    12301 tctccac
//

