LOCUS NG_008026 19527 bp DNA linear PRI 13-NOV-2010 DEFINITION Homo sapiens cholinergic receptor, nicotinic, beta 1 (muscle) (CHRNB1), RefSeqGene on chromosome 17. ACCESSION NG_008026 VERSION NG_008026.1 GI:190358473 KEYWORDS RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC113189.11. This sequence is a reference standard in the RefSeqGene project. Summary: The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-19527 AC113189.11 90170-109696 FEATURES Location/Qualifiers source 1..19527 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="17" /map="17p13.1" gene <1..4846 /gene="FGF11" /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269" /note="fibroblast growth factor 11" /db_xref="GeneID:2256" /db_xref="HGNC:3667" /db_xref="MIM:601514" mRNA join(<1385..1495,1690..1793,2508..2706,2990..4846) /gene="FGF11" /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269" /product="fibroblast growth factor 11" /transcript_id="NM_004112.2" /db_xref="GI:38683846" /db_xref="GeneID:2256" /db_xref="HGNC:3667" /db_xref="MIM:601514" CDS join(<1385..1495,1690..1793,2508..2706,2990..3060) /gene="FGF11" /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269" /exception="unclassified translation discrepancy" /note="fibroblast growth factor homologous factor 3; FHF-3; FGF-11" /codon_start=3 /product="fibroblast growth factor 11" /protein_id="NP_004103.1" /db_xref="GI:4758362" /db_xref="CCDS:CCDS11105.1" /db_xref="GeneID:2256" /db_xref="HGNC:3667" /db_xref="MIM:601514" STS 1921..2055 /gene="FGF11" /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269" /standard_name="D17S1968" /db_xref="UniSTS:11456" STS 2527..3022 /gene="FGF11" /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269" /standard_name="Fgf11" /db_xref="UniSTS:258257" STS 4059..4867 /standard_name="FGF11_2203" /db_xref="UniSTS:280669" STS 4610..4790 /gene="FGF11" /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269" /standard_name="STS-W57641" /db_xref="UniSTS:27106" STS 4638..4792 /gene="FGF11" /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269" /standard_name="RH78385" /db_xref="UniSTS:85126" STS 4705..4837 /gene="FGF11" /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269" /standard_name="G30483" /db_xref="UniSTS:67493" gene 5001..17527 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /note="cholinergic receptor, nicotinic, beta 1 (muscle)" /db_xref="GeneID:1140" /db_xref="HGNC:1961" /db_xref="MIM:100710" mRNA join(5001..5099,5184..5323,5983..6027,6747..6856, 6957..7065,7417..7564,8493..8702,14211..14434, 15198..15370,15708..15855,16497..17527) /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /product="cholinergic receptor, nicotinic, beta 1 (muscle)" /transcript_id="NM_000747.2" /db_xref="GI:41327725" /db_xref="GeneID:1140" /db_xref="HGNC:1961" /db_xref="MIM:100710" exon 5001..5099 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=1 CDS join(5042..5099,5184..5323,5983..6027,6747..6856, 6957..7065,7417..7564,8493..8702,14211..14434, 15198..15370,15708..15855,16497..16637) /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /note="cholinergic receptor, nicotinic, beta polypeptide 1 (muscle); acetylcholine receptor subunit beta" /codon_start=1 /product="acetylcholine receptor subunit beta precursor" /protein_id="NP_000738.2" /db_xref="GI:41327726" /db_xref="CCDS:CCDS11106.1" /db_xref="GeneID:1140" /db_xref="HGNC:1961" /db_xref="MIM:100710" exon 5184..5323 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=2 exon 5983..6027 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=3 STS 6152..6317 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /standard_name="AFM238WF2" /db_xref="UniSTS:2683" STS 6172..6337 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /standard_name="GDB:186817" /db_xref="UniSTS:155507" exon 6747..6856 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=4 exon 6957..7065 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=5 STS 7020..7456 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /standard_name="GDB:186812" /db_xref="UniSTS:155506" exon 7417..7564 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=6 exon 8493..8702 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=7 exon 14211..14434 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=8 exon 15198..15370 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=9 exon 15708..15855 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=10 exon 16497..17527 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /inference="alignment:Splign:1.39.8" /number=11 STS 16563..16709 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /standard_name="STS-X14830" /db_xref="UniSTS:77777" STS 17277..17453 /gene="CHRNB1" /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107; SCCMS" /standard_name="IB1796" /db_xref="UniSTS:57377" gene complement(19280..>19527) /gene="ZBTB4" /gene_synonym="KAISO-L1; KIAA1538; ZNF903" /note="zinc finger and BTB domain containing 4" /db_xref="GeneID:57659" /db_xref="HGNC:23847" /db_xref="MIM:612308" mRNA complement(19280..>19527) /gene="ZBTB4" /gene_synonym="KAISO-L1; KIAA1538; ZNF903" /product="zinc finger and BTB domain containing 4" /transcript_id="NM_020899.3" /db_xref="GI:192807283" /db_xref="GeneID:57659" /db_xref="HGNC:23847" /db_xref="MIM:612308" mRNA complement(19280..>19527) /gene="ZBTB4" /gene_synonym="KAISO-L1; KIAA1538; ZNF903" /product="zinc finger and BTB domain containing 4" /transcript_id="NM_001128833.1" /db_xref="GI:192807285" /db_xref="GeneID:57659" /db_xref="HGNC:23847" /db_xref="MIM:612308" ORIGIN 1 acacagcagt ccccaccccc atcgtcctcc gcctacgtgc cggttctcgc gattctttca 61 atctggagcg gaggggcccg ggggtttcca gatgcctggg tcaccccaag gatttctgca 121 gctccagccg cacgcccccc cccagccccc gcctgccccg gttctcccgc tcctccacgc 181 ctgggctcgg ttcctcctgg tcgagctctg ctggctccga gccaatctcc ccagctctcc 241 ctcgggtgtc cttgcagcta cctcgccagc cagccctcta tgcgccctcc tcctgtgacc 301 tgcgcttcaa gaacggagct gggcacccct cccataaccc ccgcgccact ccgaaatcgg 361 gtcccgtagg ctcaggggac cctacgctgg caggaactca gacacagttc acggctagag 421 atgggcgccg actcgggggt cgtaccacct acaagggggg acagggaagt cggcagagag 481 caagcgatgg gggaggagag ttgtgagagt tagaattggt ccccgtccat gtacgacagt 541 cagggagtcc ctctggccct gctcccgccc gctcccagct cccctaaggg tagccacctc 601 gcgccctcct ccccgcgcca ccggctgccc atagtggtac aatccgcagc ccaccctctg 661 agtaggaccg ggcccccacg tgactcagcc tgcctctcca tctcctcagc tcccaccccc 721 catatccttg gtaaggtccc ccttacccca ggcgagttac ctggccgaag gggagaggct 781 gagcctcagg gagaactggg cccccgggag ccagcggact gacagacaga cagacagaca 841 gacagatggg tcagtgtcag acaggccggc gctgggccaa ggcaaggctc tcgccaagct 901 agcggcagcc gcagcaggtg ctgagtcagc gtcaggccca gtcccacccc cactcctgag 961 ggagagcccc taccctgtgg tcaatttgct gctgccaaga tcccccacct tcgcaaacac 1021 gctgcccctt cagtacccct gctggtctcc ctctgtccct gccttttgat atatctctcc 1081 cctccctcct cccccactcc ttcccccttc tggttgagct gtagggtagg aattaagcca 1141 tttaaataaa tttcaataaa ttacactgaa agctcctggt tataggaaac agaagggacc 1201 cacaccagct ttcccaggag tgaaagagag gtgggagaga gcgtgcttgg aggataagag 1261 agctggggcc ctgggaccct cttccttcct ttcattctcc tttcttccct ctaatcctgc 1321 caagtgtagg aatgtttctg ggaacggaga tgtcattttc aaagatgaat gtctctctct 1381 ccagagcctc agctcaaagg catcgtcacc aaactgttct gccgccaggg tttctacctc 1441 caggcgaatc ccgacggaag catccagggc accccagagg ataccagctc cttcagtgag 1501 aggggaagct ggctgcaggg tgggaagggg gagaatgggg acaggagatg acaatcctat 1561 tccctcttca gcttctgttg ccattgatcc gtcttcctga cctctaaggg aaaaagtgga 1621 gctgggatga ggggagctca ggtgagggtc agaggcctgg gtattgatgc tccctctctc 1681 cacctgcagc ccacttcaac ctgatccctg tgggcctccg tgtggtcacc atccagagcg 1741 ccaagctggg tcactacatg gccatgaatg ctgagggact gctctacagt tcggtgagac 1801 aatgaggctg agtggccggg aaatactggg gactcccctt cctcaatttg tcccttgagg 1861 gaatgacaac cttcctcaac tacagacatt ttgcccggga ctcctccctc cagctttgct 1921 gatggcctgt catcgctgcc cattccagac cagctcctct agggtctctc cagtccccac 1981 tccttgcaca cccccaaaac agccccaggt tctttgaatg tccaactctt tctgcctttt 2041 agggccccta cttcttatcc cacctcctcc agattttgtc attactcact tccctagagt 2101 catccaggat aggggatagt gagagactgg gagtacagtg gagagaagga atcttattgc 2161 aagaccccta aaagtctagt tctttttttt ttttttaaat agtgacaggg tcttgctatg 2221 ttggccaggc tggtctggaa ctcctgacct caggtgatcc acccgcctcg gcctcccaaa 2281 gtgttgggat tataggcatg agccactgtg cttggcccag agcctagttc ttagccctca 2341 gccctcttcc ttgtcctccc tttgctccca ggtcctacat ggactcagaa gttgtcctcc 2401 ccctccccca aaaaggattt gtgctttcca tgagctcctt tctgcccagt gatgtgtctt 2461 tttatctctc tgtctttgtg cgcctttctg ggtctttgtc tccttagccg catttcacag 2521 ctgagtgtcg ctttaaggag tgtgtctttg agaattacta cgtcctgtac gcctctgctc 2581 tctaccgcca gcgtcgttct ggccgggcct ggtacctcgg cctggacaag gagggccagg 2641 tcatgaaggg aaaccgagtt aagaagacca aggcagctgc ccactttctg cccaagctcc 2701 tggagggtgg gtatagactc aagaaaatgt gggccacagg agagggtatt gaccttgata 2761 tggacattta ggggcagaca gctcaggcta caagtgataa gaggaccctt tgtgacagat 2821 caagccagga aggctttgcc ctttgggggt ttgggtgcgg tcctcctgtg gggttggggt 2881 tcttggaggg tgaatgtacg ggaagggagc ccttttggag cactggttct gcctgggtcc 2941 ctctgtgcct aactctcctt ccctgctcct ctctttctcc ccttcacagt ggccatgtac 3001 caggagcctt ctctccacag tgtccccgag gcctcccctt ccagtccccc tgccccctga 3061 aatgtagtcc ctggactgga ggttccctgc actcccagtg agccagccac caccacaacc 3121 tgtctcccag tcctgctctc acccctgctg ccacacacat gccctgagca gccaggtccc 3181 actaggtgct ctaccctgag ggagcctagg ggctgactgt gacttccgag gctgctgaga 3241 cccttagatc tttgggccta ggagggagtc agagaggggg atgtctgaag atggtcctgg 3301 ctgatcactt ctttctttcc acactcacac aacgccatgc cttttcctga gatggcgctg 3361 ggagttccca catggacagc cagggcataa acacttccca ccccggctca gccagttcct 3421 ggagtcctgt gccccttttc attgccactg agccatttct agattcactg gagctcagga 3481 ttcatgtgtc cttctttccc tactctacct tctaccttgg tctggacaca ttctggaaca 3541 ctggacaccc tcgccagggc cacttctgca ctagggctct gtgctggaac ccaggcatgc 3601 tgccagcctt ttctctggat ctgtcaggcc tctgtcattg actcagatgg acccctggtt 3661 tccaagtaga aagaggctag atttgggcct tgtctagctg ttggctttgg cctgaaccgg 3721 aaccagtctc agatgaccac gggtttaacc ttcttatccc agagacaccc aattctagag 3781 ctttatggag ccgtacttcc ccctgaatcc tagctctagg acatagatca tgactctcag 3841 cccttttacc caggatggag ctggggcctg tatagccata ttattgttct aagtaagttc 3901 tagccccacc ctcccgcctt cttgagtgat acctattacg gatgagttct ggaaaagacc 3961 cagctatgat tcataaaaac acttctggat gaatcaagaa ccatttcttg tttttcctag 4021 ataattctct aaaaatatga ttcttccata tagaatgcta agcttatttt tacatgcagt 4081 ttctagctcc ttcaacccag ctgaggtcgt gccagggaga cagagtctgg agaagggcag 4141 aggaattttg gaaggatccc tggctcatag tagggaagct gggatggggg aggggtcaaa 4201 attatggcat gactgaacct gcatctgtgt tgggtggaca tgaatactta gctacctcag 4261 caggaattcc ttccaggtcc cctttaaagc tgaggtcctt agagtaatat gtccttaata 4321 aaaaggacaa atggatacag ccttgaccct cccagtgagg agaccccaat tcagcaataa 4381 gtctcaccct tctcccctac aggtcaggcc aagaagggtg aaggcctctt gcactccaga 4441 cctcatacgc cccaacagct tctaattgga tagaacttgc tttaccttac agctcacaac 4501 ctcagctggg ttttaggtac ccaaaaaggg cctgtctaga ttttttcaga aaaacgtgga 4561 gtgctagggg cagcctggaa aagatgggga acctgctagt gaactaggag ggagacttcc 4621 atagcctcag acttggatag ggtaggctga gggggcccta agggagggac taaggctcca 4681 aggcaggtca cttttcctta ggctgttcta cttctggctt gttgcaagag gagtagatgc 4741 cccctcaccc acacaaaccc cactcagtct ccacccaact cctggcactg ctcccagggg 4801 atcgggtctc cactccagct ttctcaatta aagacgattt atacaactga agtgctgtct 4861 gtcatctgtc ggtggcgggc ttggcagttg ctcgaggcag gatcaagtcc cgggggcggg 4921 gcgggtgggc tggcggctgt cctccagcaa caggtgcaca ttcccgggct cctcgtcact 4981 tcccctgtgc tggcggtccc agcggctctc tgagcgaagt cactgagcga gccgccaggc 5041 tatgacccca ggggctctgc tgatgctgct gggggcgctg ggggcgccgc tcgccccagg 5101 taagtgtagg ccccgaaggg gcagtgacgg ggccagcggt cgtggccagg caccagggct 5161 gcacttattc tctcctcccc caggcgtccg cggctcggag gcggagggtc gactccggga 5221 gaaacttttc tctggctatg atagctccgt gcggccagcg cgggaggtgg gagaccgtgt 5281 cagggtcagc gttggtctca tcctggcgca actcatcagc ctggtgaggg cgcgcggggg 5341 gtggaggtca ggccagccga ccggccgggg gcgtggcttt aggcaaggcc ggaccaggga 5401 caggctgggg gcggggcctg ggacgagacc aggctgagat ggaccagcct ttggtgaaga 5461 ttggatcgaa atcagaccaa tggacaagct ctggccgtgg gtggtggacg ggcctggagt 5521 agaactgggt agggtgaagg acggacctgt gatcggacct taaagtgggg ctggggacga 5581 ggcaggggct gggggacgga cctcgacgta gggccacatg agtcctgagt gcccagggtg 5641 gggcggagct tggtgctcag gggtcaataa atggcagcgg gtggaggttc ggggctgggt 5701 ggattatgag ctgaaggcag ggccggggac agagctaggc ggagggctag gcaggggcgg 5761 gtctggtagg ttgataggct gggagtgtag acggcaggaa gaggtgtttc tgagatagag 5821 gcaggtctta aactaacgcc gcttctggga ggtggacttg gacccgagag gatggggctc 5881 agaaaaaggg ggcggcgttc ccaggagaga ggttggcccc ccgagccccc tcatttctct 5941 ccaccctact tcacctttac gccttaaatt tttcccttct agaacgagaa ggatgaagag 6001 atgagcacaa aggtgtactt agacctggta tggagacccc acggggtggg aaagggcttc 6061 cctctgcctt gacaatttcc ttgaatatcc agcccagtaa gaatattttt tacatcatga 6121 ctttagataa cacgtttata actgaagcaa aagctcgaag aaacaacact taactttact 6181 acaggagtta caccccatgc atttttaatt ccaattttgt gtgtgtgtgt gtgtgtgtgt 6241 ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgatg cggtctcact 6301 atgttgcaca ggctgttctt gaatgcgggg gctcgagcca tccaccagcc tcggggggaa 6361 cctccacaag tgctgagatt acagccgtga gccactgcac ctggcccatt ctaatttttg 6421 aaacactggt ttggggccgc taatttcatt ccccatccac taaaggattg cgaactgcag 6481 tttgaaaacc gttttagagg ctagctactg cagcctcctc atttttacag agtaaaatat 6541 tgaaacccgg tgcgggggag ggaaattagc tgatgtggat cccagcgagt gaaggcggag 6601 ccagagccag aaccacggcc ccttgaccca cagtttatgc ctgtcctgct ccccttcctt 6661 gcactccctt cctgggcttc ctttggaaat cccaagtccc tcccggcctc caacccgggg 6721 cagcccctca gcctctgctt cactaggagt ggactgacta caggctgagc tgggaccctg 6781 cggagcacga cggcatcgat tcgctccgca tcacggcgga atccgtgtgg ctccctgacg 6841 tggtgctact gaacaagtag gagaacttcc aaagcccggg aggtggcgcg gggcctcggg 6901 gggcgggggg cctccgggcg cggggcctga tccctgatga gatcccttct ctgcagcaat 6961 gatgggaatt ttgacgtggc tctggacatt agcgtcgtgg tgtcctccga cggctccgtg 7021 cgttggcaac ccccgggcat ctatcgcagc agctgcagca tccaggtttc cggcctccac 7081 attggaagct gaaggagctc ttacaaatcc tccctttcct tagacatcct gactccccgg 7141 cgactcccat ccttcatcct tcccccatta tctaatcccc atgaccctca cctcgtctac 7201 cctcctggtt ttccattgag tgttctgtac actttctttg acttctagtc ttactcagtg 7261 accgccctcc ccatccctcc cccattaatg gcttcccttc ataaccctcc aattcctcca 7321 tgatttccct tctctgtgcc ctccccaaag acctcccaaa ctccaccagc gctgactggt 7381 tctctggcag ctctagtgac tctctcctcc atccaggtca cctacttccc cttcgactgg 7441 cagaattgca ctatggtgtt cagctcctac agctacgaca gctcggaggt cagcctgcag 7501 acaggcctgg gtcctgacgg gcaagggcat caggaaatcc acattcatga agggactttc 7561 attggtgagt aggcatggct cctacatcca tgggctctat catttccagc ttctaacaga 7621 ctcataaata tactgtcagt gatgcccaat atagccctgt ggggtcagca ggatgggtat 7681 ggctatctac attttaaaag tatggaaatt gccgggggca gtggttcatg cctgcaatcc 7741 cagtactttg ggaagccgag gcgggcggat catttgaggt ctggagttcg tgaccagcct 7801 aacgtggtga aaccccgtct ctactaaaaa tgcaaaaaat tagccagtca tggtggcaga 7861 tgcctgtaat cccagctact tgggaggttg aggcaggaga atcgcttgaa cctgggaggt 7921 ggaggttgcg gtgagccgag atggcgccac tgcactccag cttcggtaac agagtgaaag 7981 ttcgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaagggc ctggcgcagt ggctcacgac 8041 ttaatctcag tattttggga ggtggaggcg ggcaaatcac ctgaggtcag gagttcgaga 8101 ccaccctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaaa ttagccaggt 8161 gtggtggtgg acacctgtaa tcccagctac ttgggaggct gaggcaggag aatcacttga 8221 acctgggagg cggaggttgc agtgagccga gatcacgcca ctgcactcca acctgggcaa 8281 caagagcaaa actctgtctc aaaataaata aataaaaata tggaaattga gacttgccca 8341 agtttattag agatgggcta ctcagcccag ttttcacagc tagtttcatc aagtcagccc 8401 tctcaggtct aggctgtggc agagcaagcc atacctggca ctaaccagga cagctctcac 8461 atctgtgttc ccctccttct gctcatcccc agagaatggc cagtgggaga ttatccacaa 8521 gccctctcgg ctaatccagc ctccaggcga tcctagggga gggagggaag gacagcgcca 8581 ggaagtcatc ttctacctca tcatccgccg caagcctctc ttctacctgg tcaacgtcat 8641 tgccccatgc atcctcatca ctcttctggc catcttcgtc ttctacctgc caccagatgc 8701 aggtaatggg ggaaggggct ccttactctt ttgtcattgg ctcagcttct tactctttat 8761 ccttaatcca ggcagggttt tcctgccaat ccaaagcatc atagattggg cttcagcaat 8821 cccgcccagg ctctgcctcc cgttgactgc cacctttcct ccgctcagtg aaactggaac 8881 tctttcctaa taggagtcct agcctctaat ccataaagcc tttactcctc tgaaccacaa 8941 acctccaggc ttagatagct ctcccattcc ctttcccaac attccctgcc cactttcaga 9001 ctcccactac tcctttaatt tttttttttt tttttgagat ggagtctcac tctgtcaccc 9061 agactggagt gcagtggtgc aatctcggct cactgcaagc tctgcctccc gggttcacgc 9121 cattctcctg cctcagcctc ccgagtagct gggactacag gtgcccgcca ccacgcccgg 9181 ctaatttttt gtatttttag tagagacgga gtttcaccgt gttagccaga atggtctcga 9241 tctcctgacc tcatgatctg cccgcctcgg cctcccaaag tgctgggatt acagtcgtga 9301 gccacagggc ccgacctttt tttttttttt tttttttttg agacagagtc ttgctctttt 9361 gcccaggctg gagtgcagtg gtgtgatcat ggcttgctac agcctcaaac tcttgggctc 9421 aaacaatcct cccacctcag cctcctgtgt aactgagacc acaagcaccc acaatcatgc 9481 ccagctgatt tttttgtatt tttggtagag aaagggtttc accatgttgc ccagcctggt 9541 ctgcaactcc tgaactcaag cgatctgttc gcctcagcct cccaacgtac tgggcttata 9601 ggcatgagcc accgcgctcg gcccccacta gtcctttaac ctcctatctc cctgggaaat 9661 atataatagt aatagccacc gggcgcggtg gctcacgcct gtaatcccag cactttggga 9721 ggccgaggtg ggtggatcac gaggtcagga gattgagacc atcctggcta acatggtgat 9781 actctatgtc tactaaaaac acaaaaaatt agccaggtgt ggtggcgggc gcctgtagtc 9841 ccagctactt gggaggctga ggcaggagaa tggcgtgaac ccgggaggcg gagcttgcag 9901 tgagccgaca ttgtgccact gaactccagc ctgggagaca gactctgtct caaaaaataa 9961 ataaataaat aaataaataa ataaataaat aaataatagt aatagtcaac atatctttag 10021 gaggcagcaa aataggataa cttttggcaa attccttaat cttttttttt ttttcgagac 10081 agagttttgc cccgttgccc aggctggaat gcagtggcat gatcttggct cactgcaacc 10141 tccacctcct gggttcaagc gattctcctg cttcagcctc ctgagtagct gggattacag 10201 gtgcccacca ccatgcctgc ctaatttttg tagttttagt agagatgggg tttcactatg 10261 ttggccaggc tggtctcgaa ctcctgacct cagtgatcca cctgcctcag cctcccaaag 10321 tgctaggatt ataggcatca gccaccacac ctggccaaat tccttaatcc ctatgtgtct 10381 cagtttcctg atctggaagt gggccaacca ttgtccctac cgcctagaat tattttgagg 10441 attgacagag ttaatagaac tatgcctggc acccagtaag ttctatgtaa gcactgggtt 10501 ttgggttgtt ttttgttttt cttttttgaa cacttgctat aaggtaattc atttaacatg 10561 gtacatgtac taattctaaa ctttacaaca atcctgtgag gtaagtaacg aattgtcatt 10621 ctcattttac agtggaggat aaagaggctg aaggagttta agtcatttgc ctgaaatcat 10681 tacacagtta gagaggggca gtgttgcaat tccaacctgg gtcagtggca gtctgattca 10741 gagacctgat atccttagct ctggtattca aaacatgctt tcctcctctc tgccatcaaa 10801 tcctttgtct aaagaaggaa agcaggctgg gcgtggtggc tcacacctgt aatcccagca 10861 ctttgggagg ctggggctgg tggatcacct gaggtcagga gtactcaaga aacagaaagg 10921 aggccagtag aactgaatga agtaagcaga ggggaaagca gtaggagatg aagtcaagga 10981 gctcatggga aggacctata gaccataacc agctgcgttt caaagggact ctagacccag 11041 gaaggcccag aaccactgat gctgagtaac acccttggcc ttctggtctg agttgctatg 11101 gccttgggca tgctagaaca ggcaagtgag tttcactggg gcatgtgttg ggtggatgtt 11161 tcaggttctt ttcttttctt ttcttttctt tttttttttt ttttttttga gacagagtct 11221 tgctctgtct cccaggctgg catgcagtgg cgcgatctcg gctcactgca acctccacct 11281 cccaggttca agcaattctc ctgcctcagc ctccctcccc ggtagccggg attacagaca 11341 tgagccacca tgcctgagta atttttctat ttttagtaga gatgggattt ctccatgttg 11401 gccaggctag tctcaaactc ctgacctaaa atgatccacc cgccttggcc tcccacagtg 11461 ctgggattac aggtgtaagc caccccgccc agcctgttat gttttttaac gttggtcttt 11521 cggccaccaa gagcccagga aggccacatg cacagctctg ccaggtgcag cccaggtgtc 11581 cagggctctc tggtccagga caccatggcc tggtgtgccc ttatctccag gcctgaagcc 11641 ccacctgtcc aacctggaga cagctatgca aggttctctt gccaggtgct gtttaatctt 11701 gggccctcca gggcctggag cagcttccag ggcccgtcct ccatgccccc acccaaggac 11761 gtcctcactc cagcaagctc agctacatgc tcagcagtca gggccactga ggccacagcc 11821 ccgccgccac ccacaccagg ctgtcctaga gggccacccc agccctggaa gccccctcaa 11881 cccctgcttt catgcaggag agggggagcc actggaaggt tctggaaaga ggaataatat 11941 gatctgattc tatttctttc tttccttttt cttttttttt ttttttttag atacagtccc 12001 tgtctgtcac ccaggctgga gtgcagtggc acgatcttgg ctcactgcaa cctccgcctc 12061 ccgggttcaa gcgattattc tgcctcagcc tcccgagtag ctgggattcc agtcacacac 12121 cacgatgccc agctaaattt tttgtaattt aagtagagat ggggtttcgc tatgttggcc 12181 aggctggtct cgaacttctg acctcaggtg atctgaccgc ctcagcctcc caaaatgcta 12241 ggattacagg catgagccac cgcacccagc ttgatttata ttttaacaaa atcagtctgg 12301 ctgctcggtt gagaacagtc agcatgggag aaaaggatgg agcaaagaga ccagttagga 12361 gggctttaca ataattcaga cctaaggtaa tgtgctttag agcaaggtgg tgatgtagga 12421 ggtgggactc gactccagac caaattgagg accagctaga acaggaacag ggcagatgca 12481 gctttccata agacatactc acgagtgtgc catgtcagtt taccattgcc atggaaacac 12541 ctgggagtta ccaccccttt ggcaatcacc tgatgacaca gaagttactg ccctttccct 12601 agaaatttct gcctaatccg ttgcttaatc tgcatgcaat taaacgtagg tataggccag 12661 gcgtggtggc tcacgcctgt aatcccagca ctttgggagg ctaaggtggg cagatccctt 12721 aaggtcagga gttcaagacc agcctggcca acatggtgaa accctgtctc tactaaaaat 12781 acaaaaagtt agccaagtgt ggtgccatgc acctgtaatc ccagctgctc gggaggctaa 12841 gacaggagaa ctgcttgaac ccaagaggca gaggttgcag tgagctgcaa tcacgccact 12901 aaactccagc ctgggtgaca gagtgagagt ctgtctaaaa ataaataaat acataagaga 12961 tagggaagac tatcagagga gtagctttgg tagtaagata atttagtttt ggacattttg 13021 ttttattttg tttctgcttt tgttttttga gatggagttt tgctcttgat gcccaggctg 13081 gagtgcaatg gcacgatctc gactcactgc aacctctgcc tcctgggttc gagtgattct 13141 cctgcctcag cctccctagt agctgggact acaggcaccc accaccatgc ccagctaatt 13201 ttttgtattt ttagtagaga tggggtttca ctatgttggc caggctggtc tcgaacccct 13261 gacctcaggt gattcgcctg cctcggcctc gcaaagtgct gggattacgg gtgtgagcca 13321 ctgtacccgg ctcagttttg gacatgttaa gcttgaaata tttattagac atccaactat 13381 ccaagagagg ttgagtaggc agatggatat atatctggca ttcaggggag aagtccaggg 13441 tggacataca aatgtaggaa tgatttacat gcagatggcc cttccaaaag cctgtctttt 13501 tttttttttt ttttttttta tgatggagtt ttgctctgtt gctcaggctg gaaggcagtg 13561 gtgccatcac agctcactgc agcctccatc ttccacactc aagcagtcct cccaactcag 13621 cctctcaaat agttgggacc acaagcatgc gccattgtgc ctggctaatt tttttttttt 13681 tctttttgta gaggttgggc aaagtggctc acgcctgtaa tcccaacagt ttgggaggcc 13741 aaggtgggtg gatcacttga gctcaggagt ttgagaccag cctgggtaac atggtgaaat 13801 cctgtctcta caaaaagtac aaaaattagc tgggcatggt ggcgtgcacc tgtagtccca 13861 gctactcagg aggccgaggt gggaagacca cttgagcctg ggaagtggag gtttcaatga 13921 gccattatca tgccactgca ctccagcctg ggtgacagag caagacccag cctcaaattt 13981 gtttttgtag aaaagaggtc tccctatgtt gctcaggctg gtctgaaact cctgggctca 14041 agcaatcctc ccaccttggc ctcccaaagt gccaggacta caggtgtgaa ccactgtgcc 14101 tggctgtaga aatctgtctt tgaatggcct ggaaacatgg tcactgatta tgccatagag 14161 ctttccttca ggcaagtcta atccttctct cttcccctct gccctccaag gagagaagat 14221 ggggctctca atctttgccc tgctgaccct tactgtgttc ctgctgctgc tggctgacaa 14281 agtacctgag acctcactat cagtacccat tattatcaag tacctcatgt ttaccatggt 14341 cctcgtcacc ttctcagtca tccttagtgt cgtggttctc aacctgcacc accgctcacc 14401 ccacacccac caaatgcccc tttgggtccg tcaggtaaga aagatctcct cctccaaccc 14461 caattttcct tttacagacc atagggagaa ctatagctat gtggcagagt gttgaagtgt 14521 ccaagcttgt tgagtgttga aatgttgcac agttaagcta gcccccatca ttatcatttc 14581 acagatccca tactctcttc atcaatactg cccatctcgg gtcccaggga aatattctta 14641 gggttaggta ctatcagatt ggaagccctc tctttccagt tgggatacct cccaacccac 14701 taaatagctt tttttttttt tttttttttt ttttgagatg gagttttgtt cttgtggcca 14761 ggctggagtg caatggcaca atctcagctc actgcaacct tcacctccca ggttccagcg 14821 attctcctgc ctgagcctcc caagtagctg ggattacagg cacccgccac cacgcccagc 14881 taatttttgt atttttagta gagagagggt ttcaccatgt tggccaggct ggtcttgaac 14941 tcctgacctc aggtgatcca cctgccttgg cttcccaaag tgctgcgatt acaggcgtga 15001 gccaccgcga caggcccaac ccactaaaga gctcttaggt ctgtgtggct gcatttcctt 15061 gtgtagctcg tttgtggaag aatatgcacg cacatactca cgcgcgggaa tgggcatgtg 15121 gagtggggtg gttggctgtt tcccttctgg tctgaaagca tgaaagcccc caccaatacg 15181 cctcttctac tctgcagatc ttcattcaca aacttccgct gtacctgcgt ctaaaaaggc 15241 ccaaacccga gagagacctg atgccggagc cccctcactg ttcttctcca ggaagtggct 15301 ggggtcgggg aacagatgaa tatttcatcc ggaagccgcc aagtgatttt ctcttcccca 15361 aacccaatag gtaggactac gcccgttacc cacataagag ggagagggag aactacagtt 15421 cccagaagag tgtgcggaag aagcggccca tgctctcgga agacgctgtg gttgagcatc 15481 atgggagttg tagtactcct gctgctcact ttgaggggag gtgggaacta aaacagaggc 15541 ggtggaagaa gttgcacaag gctagagaga tcactgctgg agggaaaagc atgatgggct 15601 ctcgggtttt gagaactggc aagttgttgg aggcagctgg agcggggcct gggtcgccgg 15661 cactggctgt ctttgcgttt gggcgtggcc agtcactcct cttccaggtt ccagcctgaa 15721 ctgtctgccc ctgatctgcg gcgatttatc gatggtccaa accgggctgt ggccctgctt 15781 ccggagctac gggaggtcgt ctcctctatc agctacatcg ctcgacagct gcaggaacag 15841 gaggaccacg atgcggtatg tccaacgggg gtggaacaag gccaggtcta ggcgaccttg 15901 gccccacccc caaattccgc accagcactc gctttcgttt tttttgtgtg gttttttttt 15961 ggcttttttt tttttttttt ttttttgaga cagagtctcg ctctgtcgcc caggctggag 16021 tgcagtggct cgatctcggc tcactgcaac ctccgcctac gggttcaagc gattgtcctg 16081 cctcagcctg ccgagtagct gggacgacag gggcgcgcca ccacgcctgg ctaatttttg 16141 tatttttagt agagacgtgg cttcaccatg ttggccaggc tggtctgaaa ctcctgacct 16201 caggtgatcc gctcgcttcg gcctcccaaa gtgctgggat tacaggcgtg agccaccgcg 16261 cccggcctcg ctttcgtttc tgattggacc tctccctcat ttggtcccac cccctgctta 16321 cctactggtt ctttatgccc atgcattgcc tgcagtctcg ctctcctgtt ggcgctgccg 16381 gctgttgcct caaaccagtg gtaggaggac tcaagcgggt agcgggcggg gaaatggggg 16441 ggtttccctg ggggtctggg cccagagctc aggaagtttc ctttgcctac ccacagctga 16501 aggaggactg gcagtttgtg gccatggtag tggaccgcct cttcctgtgg actttcatca 16561 tcttcaccag cgttgggacc ctagtcatct tcctggacgc cacgtaccac ttgccccctc 16621 cagacccctt tccttgaaga ctggagggtt gagacccagg ccccctgcca gttgaagtga 16681 gagtttggtg atactgtcaa gccctatcct tctctgcctc ttaactcctt cacgaggaat 16741 ctgggcctct tatttcgttt ctggggactg cattggactg agggctgggt aggcaggtgt 16801 cttggaccca cctgaaatgc agtatcatct gatttactct ttgggatctt gaagaagctc 16861 ttttgggtat caacacctag gtcgccagtg aaatagaaca cagaacagga actagattat 16921 aagccttatg aggtcaagaa atgtgacttg gccgggcgcg gtggctcacg cctgtaatcc 16981 cagcactttg ggaggccaag gcgggcggat cacctgaggt cgggagtttg agaccagccc 17041 gaccaacatg gagaaaccct gtctctacta aaaatacaaa attagccagg tgtggtggta 17101 catgcctgta atcccagcta ctagggaggc tgaggcagga gaatcactcg aacccgggag 17161 gcagaggttg cagtgagtca agatcacgcc attgcactcc agcctgggca acaagagcga 17221 aactccatct caaaaaaaaa aaagtgtctt gttcactgca gcatgcccag tgccacgcac 17281 aggtgctgac ctatagtaag tgcttaacat ttgttgaata ggggaaagaa atttccggaa 17341 gtaaatacag caattaataa tgtttataag ctgggcatgg tcgctcaggc cagtaatccc 17401 agtgacttag gaggctgagg tgggaggatt acttgaaacc cacagtttga gaccagcctg 17461 ggcaacatag tgagaccctg tctctaaaaa aataaaaata gaaataaagt agtgcttatt 17521 gtttgcatgt tgggtcttgt ggtcgttttc tttttacctt tctgtaattt attatgtttt 17581 gtaatgtgta ctatctctgg gattaaaaaa agttatttct acaagcatgc attggtaatg 17641 agaaaaaaca agcgttttga aggccttcat tcaagttcca accttggtgc tcacacaagc 17701 cactagcttg ctctgtactt gtttcgacat ctgtaaaatg aaactaatga tagcatatgc 17761 cctataggat tgtctgggga tcacaggaga tgggaaaaaa gcactatgcg atatgtatca 17821 gaggttgcaa cggtgtgttt tttgtttggc ctgcacagtt ttaaatttga actagttcac 17881 tacttttatt ttttattttt tttcaagaca gagtctcgct gtgttgccca ggctggagtg 17941 cagtggcggg acctcggctc accacaacct ctgcctcccg ggttcaagtg attctcctgg 18001 ctcagcctcc tgagtacctg ggactgcaga cccacaccac catgcccagc taatttttgt 18061 acttttagta gagatggggt ttcactatgt tggccaggct ggtctagaac tcctgacctc 18121 gtgatctgcc cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc catcacgcct 18181 ggctactagt tcactgcttt taaaatgtgg atatttcatg agaaatttgg cttcctggct 18241 tctcttgaaa ataatcttat ttaaaaaaaa actatagaga cagggtctca ctatgttgcc 18301 caggctggtc ttgaacttct gagctcaagt gatccacctg ccttggcctc ccaaaatgct 18361 gggattacag gtatgagcca tcacacccag cctcaaagat aattttaaaa actatagtag 18421 tccgggcgtg gtggtttatg cctgtaatcc cagcactttg ggaggctgaa gcaggcagat 18481 cacgaagtca ggagttcgaa accagcctga ccaacatgct gaaaccccgt ctctactaaa 18541 aatacaaaaa ttagctggat gtggtggcgt gcacctgtaa tcccagctac tcaggagcct 18601 gaggcaggag aatcgcttga acctgggagg tggaggttgc agcgagccaa gatcgtgcca 18661 ctgcactcca gcctgggcaa caagagcgaa actccatctc aaacaacaac aacaacaaaa 18721 aactatagta acaccaggcc tgattcccct gttggcaaca acttgtgtag agcttagtgg 18781 ctgccactct ggtcaagtta ttcataccat aattcctcaa agcccctgta aacctgaccc 18841 acgtcactta gtttacctgc ccatccctcc gtaacactag aaaagataca gggggcaacg 18901 aattgaagcc aatggggaag ccacaagtgg aaaaagaaag gttgtgtctc ttatggccat 18961 cacacatttt atgcctcagt tttctttcaa tttggaagga aggttagacc tggtttaagg 19021 cagggccatt ttggacatag agatctcgcg cccagcaggt tgtatgaact agactgttaa 19081 tatttctggc tggatgttgg gccaaagtca gcttgagcct acagtcaaca agccctcact 19141 caactactca actgctggaa gttgcgtcca aacagggagc attgggccac aactcacagg 19201 gatccttgtg ggacaaagtt agcatgttcc tttcccccag acccaccagc cacgcaaata 19261 attgcacctg gcatcccact gtggagcaca gttcatttgt cttgttggtt tattggccta 19321 cagagttgga cacacacaca aatgcggaga taaatattgg tcagtttctc taaatctggg 19381 tcctcactac gtatagagct agtctgtaga attctaaatt ttgcgtgctg cggcacagaa 19441 ccagtggcct tctcactctg ccaccacccg tcttcccagg gaacatgggg aaagagggca 19501 cgaactgaca agacttgatc attttca //