LOCUS       NG_008026              19527 bp    DNA     linear   PRI 13-NOV-2010
DEFINITION  Homo sapiens cholinergic receptor, nicotinic, beta 1 (muscle)
            (CHRNB1), RefSeqGene on chromosome 17.
ACCESSION   NG_008026
VERSION     NG_008026.1  GI:190358473
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113189.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The muscle acetylcholine receptor is composed of five
            subunits: two alpha subunits and one beta, one gamma, and one delta
            subunit. This gene encodes the beta subunit of the acetylcholine
            receptor. The acetylcholine receptor changes conformation upon
            acetylcholine binding leading to the opening of an ion-conducting
            channel across the plasma membrane. Mutations in this gene are
            associated with slow-channel congenital myasthenic syndrome.
            [provided by RefSeq].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19527             AC113189.11        90170-109696
FEATURES             Location/Qualifiers
     source          1..19527
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            <1..4846
                     /gene="FGF11"
                     /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269"
                     /note="fibroblast growth factor 11"
                     /db_xref="GeneID:2256"
                     /db_xref="HGNC:3667"
                     /db_xref="MIM:601514"
     mRNA            join(<1385..1495,1690..1793,2508..2706,2990..4846)
                     /gene="FGF11"
                     /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269"
                     /product="fibroblast growth factor 11"
                     /transcript_id="NM_004112.2"
                     /db_xref="GI:38683846"
                     /db_xref="GeneID:2256"
                     /db_xref="HGNC:3667"
                     /db_xref="MIM:601514"
     CDS             join(<1385..1495,1690..1793,2508..2706,2990..3060)
                     /gene="FGF11"
                     /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269"
                     /exception="unclassified translation discrepancy"
                     /note="fibroblast growth factor homologous factor 3;
                     FHF-3; FGF-11"
                     /codon_start=3
                     /product="fibroblast growth factor 11"
                     /protein_id="NP_004103.1"
                     /db_xref="GI:4758362"
                     /db_xref="CCDS:CCDS11105.1"
                     /db_xref="GeneID:2256"
                     /db_xref="HGNC:3667"
                     /db_xref="MIM:601514"
     STS             1921..2055
                     /gene="FGF11"
                     /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269"
                     /standard_name="D17S1968"
                     /db_xref="UniSTS:11456"
     STS             2527..3022
                     /gene="FGF11"
                     /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269"
                     /standard_name="Fgf11"
                     /db_xref="UniSTS:258257"
     STS             4059..4867
                     /standard_name="FGF11_2203"
                     /db_xref="UniSTS:280669"
     STS             4610..4790
                     /gene="FGF11"
                     /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269"
                     /standard_name="STS-W57641"
                     /db_xref="UniSTS:27106"
     STS             4638..4792
                     /gene="FGF11"
                     /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269"
                     /standard_name="RH78385"
                     /db_xref="UniSTS:85126"
     STS             4705..4837
                     /gene="FGF11"
                     /gene_synonym="FHF3; FLJ16061; MGC102953; MGC45269"
                     /standard_name="G30483"
                     /db_xref="UniSTS:67493"
     gene            5001..17527
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /note="cholinergic receptor, nicotinic, beta 1 (muscle)"
                     /db_xref="GeneID:1140"
                     /db_xref="HGNC:1961"
                     /db_xref="MIM:100710"
     mRNA            join(5001..5099,5184..5323,5983..6027,6747..6856,
                     6957..7065,7417..7564,8493..8702,14211..14434,
                     15198..15370,15708..15855,16497..17527)
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /product="cholinergic receptor, nicotinic, beta 1
                     (muscle)"
                     /transcript_id="NM_000747.2"
                     /db_xref="GI:41327725"
                     /db_xref="GeneID:1140"
                     /db_xref="HGNC:1961"
                     /db_xref="MIM:100710"
     exon            5001..5099
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(5042..5099,5184..5323,5983..6027,6747..6856,
                     6957..7065,7417..7564,8493..8702,14211..14434,
                     15198..15370,15708..15855,16497..16637)
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /note="cholinergic receptor, nicotinic, beta polypeptide 1
                     (muscle); acetylcholine receptor subunit beta"
                     /codon_start=1
                     /product="acetylcholine receptor subunit beta precursor"
                     /protein_id="NP_000738.2"
                     /db_xref="GI:41327726"
                     /db_xref="CCDS:CCDS11106.1"
                     /db_xref="GeneID:1140"
                     /db_xref="HGNC:1961"
                     /db_xref="MIM:100710"
     exon            5184..5323
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            5983..6027
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     STS             6152..6317
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /standard_name="AFM238WF2"
                     /db_xref="UniSTS:2683"
     STS             6172..6337
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /standard_name="GDB:186817"
                     /db_xref="UniSTS:155507"
     exon            6747..6856
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     exon            6957..7065
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     STS             7020..7456
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /standard_name="GDB:186812"
                     /db_xref="UniSTS:155506"
     exon            7417..7564
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     exon            8493..8702
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=7
     exon            14211..14434
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=8
     exon            15198..15370
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=9
     exon            15708..15855
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=10
     exon            16497..17527
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /inference="alignment:Splign:1.39.8"
                     /number=11
     STS             16563..16709
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /standard_name="STS-X14830"
                     /db_xref="UniSTS:77777"
     STS             17277..17453
                     /gene="CHRNB1"
                     /gene_synonym="ACHRB; CHRNB; CMS1D; CMS2A; FLJ57107;
                     SCCMS"
                     /standard_name="IB1796"
                     /db_xref="UniSTS:57377"
     gene            complement(19280..>19527)
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; KIAA1538; ZNF903"
                     /note="zinc finger and BTB domain containing 4"
                     /db_xref="GeneID:57659"
                     /db_xref="HGNC:23847"
                     /db_xref="MIM:612308"
     mRNA            complement(19280..>19527)
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; KIAA1538; ZNF903"
                     /product="zinc finger and BTB domain containing 4"
                     /transcript_id="NM_020899.3"
                     /db_xref="GI:192807283"
                     /db_xref="GeneID:57659"
                     /db_xref="HGNC:23847"
                     /db_xref="MIM:612308"
     mRNA            complement(19280..>19527)
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; KIAA1538; ZNF903"
                     /product="zinc finger and BTB domain containing 4"
                     /transcript_id="NM_001128833.1"
                     /db_xref="GI:192807285"
                     /db_xref="GeneID:57659"
                     /db_xref="HGNC:23847"
                     /db_xref="MIM:612308"
ORIGIN      
        1 acacagcagt ccccaccccc atcgtcctcc gcctacgtgc cggttctcgc gattctttca
       61 atctggagcg gaggggcccg ggggtttcca gatgcctggg tcaccccaag gatttctgca
      121 gctccagccg cacgcccccc cccagccccc gcctgccccg gttctcccgc tcctccacgc
      181 ctgggctcgg ttcctcctgg tcgagctctg ctggctccga gccaatctcc ccagctctcc
      241 ctcgggtgtc cttgcagcta cctcgccagc cagccctcta tgcgccctcc tcctgtgacc
      301 tgcgcttcaa gaacggagct gggcacccct cccataaccc ccgcgccact ccgaaatcgg
      361 gtcccgtagg ctcaggggac cctacgctgg caggaactca gacacagttc acggctagag
      421 atgggcgccg actcgggggt cgtaccacct acaagggggg acagggaagt cggcagagag
      481 caagcgatgg gggaggagag ttgtgagagt tagaattggt ccccgtccat gtacgacagt
      541 cagggagtcc ctctggccct gctcccgccc gctcccagct cccctaaggg tagccacctc
      601 gcgccctcct ccccgcgcca ccggctgccc atagtggtac aatccgcagc ccaccctctg
      661 agtaggaccg ggcccccacg tgactcagcc tgcctctcca tctcctcagc tcccaccccc
      721 catatccttg gtaaggtccc ccttacccca ggcgagttac ctggccgaag gggagaggct
      781 gagcctcagg gagaactggg cccccgggag ccagcggact gacagacaga cagacagaca
      841 gacagatggg tcagtgtcag acaggccggc gctgggccaa ggcaaggctc tcgccaagct
      901 agcggcagcc gcagcaggtg ctgagtcagc gtcaggccca gtcccacccc cactcctgag
      961 ggagagcccc taccctgtgg tcaatttgct gctgccaaga tcccccacct tcgcaaacac
     1021 gctgcccctt cagtacccct gctggtctcc ctctgtccct gccttttgat atatctctcc
     1081 cctccctcct cccccactcc ttcccccttc tggttgagct gtagggtagg aattaagcca
     1141 tttaaataaa tttcaataaa ttacactgaa agctcctggt tataggaaac agaagggacc
     1201 cacaccagct ttcccaggag tgaaagagag gtgggagaga gcgtgcttgg aggataagag
     1261 agctggggcc ctgggaccct cttccttcct ttcattctcc tttcttccct ctaatcctgc
     1321 caagtgtagg aatgtttctg ggaacggaga tgtcattttc aaagatgaat gtctctctct
     1381 ccagagcctc agctcaaagg catcgtcacc aaactgttct gccgccaggg tttctacctc
     1441 caggcgaatc ccgacggaag catccagggc accccagagg ataccagctc cttcagtgag
     1501 aggggaagct ggctgcaggg tgggaagggg gagaatgggg acaggagatg acaatcctat
     1561 tccctcttca gcttctgttg ccattgatcc gtcttcctga cctctaaggg aaaaagtgga
     1621 gctgggatga ggggagctca ggtgagggtc agaggcctgg gtattgatgc tccctctctc
     1681 cacctgcagc ccacttcaac ctgatccctg tgggcctccg tgtggtcacc atccagagcg
     1741 ccaagctggg tcactacatg gccatgaatg ctgagggact gctctacagt tcggtgagac
     1801 aatgaggctg agtggccggg aaatactggg gactcccctt cctcaatttg tcccttgagg
     1861 gaatgacaac cttcctcaac tacagacatt ttgcccggga ctcctccctc cagctttgct
     1921 gatggcctgt catcgctgcc cattccagac cagctcctct agggtctctc cagtccccac
     1981 tccttgcaca cccccaaaac agccccaggt tctttgaatg tccaactctt tctgcctttt
     2041 agggccccta cttcttatcc cacctcctcc agattttgtc attactcact tccctagagt
     2101 catccaggat aggggatagt gagagactgg gagtacagtg gagagaagga atcttattgc
     2161 aagaccccta aaagtctagt tctttttttt ttttttaaat agtgacaggg tcttgctatg
     2221 ttggccaggc tggtctggaa ctcctgacct caggtgatcc acccgcctcg gcctcccaaa
     2281 gtgttgggat tataggcatg agccactgtg cttggcccag agcctagttc ttagccctca
     2341 gccctcttcc ttgtcctccc tttgctccca ggtcctacat ggactcagaa gttgtcctcc
     2401 ccctccccca aaaaggattt gtgctttcca tgagctcctt tctgcccagt gatgtgtctt
     2461 tttatctctc tgtctttgtg cgcctttctg ggtctttgtc tccttagccg catttcacag
     2521 ctgagtgtcg ctttaaggag tgtgtctttg agaattacta cgtcctgtac gcctctgctc
     2581 tctaccgcca gcgtcgttct ggccgggcct ggtacctcgg cctggacaag gagggccagg
     2641 tcatgaaggg aaaccgagtt aagaagacca aggcagctgc ccactttctg cccaagctcc
     2701 tggagggtgg gtatagactc aagaaaatgt gggccacagg agagggtatt gaccttgata
     2761 tggacattta ggggcagaca gctcaggcta caagtgataa gaggaccctt tgtgacagat
     2821 caagccagga aggctttgcc ctttgggggt ttgggtgcgg tcctcctgtg gggttggggt
     2881 tcttggaggg tgaatgtacg ggaagggagc ccttttggag cactggttct gcctgggtcc
     2941 ctctgtgcct aactctcctt ccctgctcct ctctttctcc ccttcacagt ggccatgtac
     3001 caggagcctt ctctccacag tgtccccgag gcctcccctt ccagtccccc tgccccctga
     3061 aatgtagtcc ctggactgga ggttccctgc actcccagtg agccagccac caccacaacc
     3121 tgtctcccag tcctgctctc acccctgctg ccacacacat gccctgagca gccaggtccc
     3181 actaggtgct ctaccctgag ggagcctagg ggctgactgt gacttccgag gctgctgaga
     3241 cccttagatc tttgggccta ggagggagtc agagaggggg atgtctgaag atggtcctgg
     3301 ctgatcactt ctttctttcc acactcacac aacgccatgc cttttcctga gatggcgctg
     3361 ggagttccca catggacagc cagggcataa acacttccca ccccggctca gccagttcct
     3421 ggagtcctgt gccccttttc attgccactg agccatttct agattcactg gagctcagga
     3481 ttcatgtgtc cttctttccc tactctacct tctaccttgg tctggacaca ttctggaaca
     3541 ctggacaccc tcgccagggc cacttctgca ctagggctct gtgctggaac ccaggcatgc
     3601 tgccagcctt ttctctggat ctgtcaggcc tctgtcattg actcagatgg acccctggtt
     3661 tccaagtaga aagaggctag atttgggcct tgtctagctg ttggctttgg cctgaaccgg
     3721 aaccagtctc agatgaccac gggtttaacc ttcttatccc agagacaccc aattctagag
     3781 ctttatggag ccgtacttcc ccctgaatcc tagctctagg acatagatca tgactctcag
     3841 cccttttacc caggatggag ctggggcctg tatagccata ttattgttct aagtaagttc
     3901 tagccccacc ctcccgcctt cttgagtgat acctattacg gatgagttct ggaaaagacc
     3961 cagctatgat tcataaaaac acttctggat gaatcaagaa ccatttcttg tttttcctag
     4021 ataattctct aaaaatatga ttcttccata tagaatgcta agcttatttt tacatgcagt
     4081 ttctagctcc ttcaacccag ctgaggtcgt gccagggaga cagagtctgg agaagggcag
     4141 aggaattttg gaaggatccc tggctcatag tagggaagct gggatggggg aggggtcaaa
     4201 attatggcat gactgaacct gcatctgtgt tgggtggaca tgaatactta gctacctcag
     4261 caggaattcc ttccaggtcc cctttaaagc tgaggtcctt agagtaatat gtccttaata
     4321 aaaaggacaa atggatacag ccttgaccct cccagtgagg agaccccaat tcagcaataa
     4381 gtctcaccct tctcccctac aggtcaggcc aagaagggtg aaggcctctt gcactccaga
     4441 cctcatacgc cccaacagct tctaattgga tagaacttgc tttaccttac agctcacaac
     4501 ctcagctggg ttttaggtac ccaaaaaggg cctgtctaga ttttttcaga aaaacgtgga
     4561 gtgctagggg cagcctggaa aagatgggga acctgctagt gaactaggag ggagacttcc
     4621 atagcctcag acttggatag ggtaggctga gggggcccta agggagggac taaggctcca
     4681 aggcaggtca cttttcctta ggctgttcta cttctggctt gttgcaagag gagtagatgc
     4741 cccctcaccc acacaaaccc cactcagtct ccacccaact cctggcactg ctcccagggg
     4801 atcgggtctc cactccagct ttctcaatta aagacgattt atacaactga agtgctgtct
     4861 gtcatctgtc ggtggcgggc ttggcagttg ctcgaggcag gatcaagtcc cgggggcggg
     4921 gcgggtgggc tggcggctgt cctccagcaa caggtgcaca ttcccgggct cctcgtcact
     4981 tcccctgtgc tggcggtccc agcggctctc tgagcgaagt cactgagcga gccgccaggc
     5041 tatgacccca ggggctctgc tgatgctgct gggggcgctg ggggcgccgc tcgccccagg
     5101 taagtgtagg ccccgaaggg gcagtgacgg ggccagcggt cgtggccagg caccagggct
     5161 gcacttattc tctcctcccc caggcgtccg cggctcggag gcggagggtc gactccggga
     5221 gaaacttttc tctggctatg atagctccgt gcggccagcg cgggaggtgg gagaccgtgt
     5281 cagggtcagc gttggtctca tcctggcgca actcatcagc ctggtgaggg cgcgcggggg
     5341 gtggaggtca ggccagccga ccggccgggg gcgtggcttt aggcaaggcc ggaccaggga
     5401 caggctgggg gcggggcctg ggacgagacc aggctgagat ggaccagcct ttggtgaaga
     5461 ttggatcgaa atcagaccaa tggacaagct ctggccgtgg gtggtggacg ggcctggagt
     5521 agaactgggt agggtgaagg acggacctgt gatcggacct taaagtgggg ctggggacga
     5581 ggcaggggct gggggacgga cctcgacgta gggccacatg agtcctgagt gcccagggtg
     5641 gggcggagct tggtgctcag gggtcaataa atggcagcgg gtggaggttc ggggctgggt
     5701 ggattatgag ctgaaggcag ggccggggac agagctaggc ggagggctag gcaggggcgg
     5761 gtctggtagg ttgataggct gggagtgtag acggcaggaa gaggtgtttc tgagatagag
     5821 gcaggtctta aactaacgcc gcttctggga ggtggacttg gacccgagag gatggggctc
     5881 agaaaaaggg ggcggcgttc ccaggagaga ggttggcccc ccgagccccc tcatttctct
     5941 ccaccctact tcacctttac gccttaaatt tttcccttct agaacgagaa ggatgaagag
     6001 atgagcacaa aggtgtactt agacctggta tggagacccc acggggtggg aaagggcttc
     6061 cctctgcctt gacaatttcc ttgaatatcc agcccagtaa gaatattttt tacatcatga
     6121 ctttagataa cacgtttata actgaagcaa aagctcgaag aaacaacact taactttact
     6181 acaggagtta caccccatgc atttttaatt ccaattttgt gtgtgtgtgt gtgtgtgtgt
     6241 ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgatg cggtctcact
     6301 atgttgcaca ggctgttctt gaatgcgggg gctcgagcca tccaccagcc tcggggggaa
     6361 cctccacaag tgctgagatt acagccgtga gccactgcac ctggcccatt ctaatttttg
     6421 aaacactggt ttggggccgc taatttcatt ccccatccac taaaggattg cgaactgcag
     6481 tttgaaaacc gttttagagg ctagctactg cagcctcctc atttttacag agtaaaatat
     6541 tgaaacccgg tgcgggggag ggaaattagc tgatgtggat cccagcgagt gaaggcggag
     6601 ccagagccag aaccacggcc ccttgaccca cagtttatgc ctgtcctgct ccccttcctt
     6661 gcactccctt cctgggcttc ctttggaaat cccaagtccc tcccggcctc caacccgggg
     6721 cagcccctca gcctctgctt cactaggagt ggactgacta caggctgagc tgggaccctg
     6781 cggagcacga cggcatcgat tcgctccgca tcacggcgga atccgtgtgg ctccctgacg
     6841 tggtgctact gaacaagtag gagaacttcc aaagcccggg aggtggcgcg gggcctcggg
     6901 gggcgggggg cctccgggcg cggggcctga tccctgatga gatcccttct ctgcagcaat
     6961 gatgggaatt ttgacgtggc tctggacatt agcgtcgtgg tgtcctccga cggctccgtg
     7021 cgttggcaac ccccgggcat ctatcgcagc agctgcagca tccaggtttc cggcctccac
     7081 attggaagct gaaggagctc ttacaaatcc tccctttcct tagacatcct gactccccgg
     7141 cgactcccat ccttcatcct tcccccatta tctaatcccc atgaccctca cctcgtctac
     7201 cctcctggtt ttccattgag tgttctgtac actttctttg acttctagtc ttactcagtg
     7261 accgccctcc ccatccctcc cccattaatg gcttcccttc ataaccctcc aattcctcca
     7321 tgatttccct tctctgtgcc ctccccaaag acctcccaaa ctccaccagc gctgactggt
     7381 tctctggcag ctctagtgac tctctcctcc atccaggtca cctacttccc cttcgactgg
     7441 cagaattgca ctatggtgtt cagctcctac agctacgaca gctcggaggt cagcctgcag
     7501 acaggcctgg gtcctgacgg gcaagggcat caggaaatcc acattcatga agggactttc
     7561 attggtgagt aggcatggct cctacatcca tgggctctat catttccagc ttctaacaga
     7621 ctcataaata tactgtcagt gatgcccaat atagccctgt ggggtcagca ggatgggtat
     7681 ggctatctac attttaaaag tatggaaatt gccgggggca gtggttcatg cctgcaatcc
     7741 cagtactttg ggaagccgag gcgggcggat catttgaggt ctggagttcg tgaccagcct
     7801 aacgtggtga aaccccgtct ctactaaaaa tgcaaaaaat tagccagtca tggtggcaga
     7861 tgcctgtaat cccagctact tgggaggttg aggcaggaga atcgcttgaa cctgggaggt
     7921 ggaggttgcg gtgagccgag atggcgccac tgcactccag cttcggtaac agagtgaaag
     7981 ttcgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaagggc ctggcgcagt ggctcacgac
     8041 ttaatctcag tattttggga ggtggaggcg ggcaaatcac ctgaggtcag gagttcgaga
     8101 ccaccctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaaa ttagccaggt
     8161 gtggtggtgg acacctgtaa tcccagctac ttgggaggct gaggcaggag aatcacttga
     8221 acctgggagg cggaggttgc agtgagccga gatcacgcca ctgcactcca acctgggcaa
     8281 caagagcaaa actctgtctc aaaataaata aataaaaata tggaaattga gacttgccca
     8341 agtttattag agatgggcta ctcagcccag ttttcacagc tagtttcatc aagtcagccc
     8401 tctcaggtct aggctgtggc agagcaagcc atacctggca ctaaccagga cagctctcac
     8461 atctgtgttc ccctccttct gctcatcccc agagaatggc cagtgggaga ttatccacaa
     8521 gccctctcgg ctaatccagc ctccaggcga tcctagggga gggagggaag gacagcgcca
     8581 ggaagtcatc ttctacctca tcatccgccg caagcctctc ttctacctgg tcaacgtcat
     8641 tgccccatgc atcctcatca ctcttctggc catcttcgtc ttctacctgc caccagatgc
     8701 aggtaatggg ggaaggggct ccttactctt ttgtcattgg ctcagcttct tactctttat
     8761 ccttaatcca ggcagggttt tcctgccaat ccaaagcatc atagattggg cttcagcaat
     8821 cccgcccagg ctctgcctcc cgttgactgc cacctttcct ccgctcagtg aaactggaac
     8881 tctttcctaa taggagtcct agcctctaat ccataaagcc tttactcctc tgaaccacaa
     8941 acctccaggc ttagatagct ctcccattcc ctttcccaac attccctgcc cactttcaga
     9001 ctcccactac tcctttaatt tttttttttt tttttgagat ggagtctcac tctgtcaccc
     9061 agactggagt gcagtggtgc aatctcggct cactgcaagc tctgcctccc gggttcacgc
     9121 cattctcctg cctcagcctc ccgagtagct gggactacag gtgcccgcca ccacgcccgg
     9181 ctaatttttt gtatttttag tagagacgga gtttcaccgt gttagccaga atggtctcga
     9241 tctcctgacc tcatgatctg cccgcctcgg cctcccaaag tgctgggatt acagtcgtga
     9301 gccacagggc ccgacctttt tttttttttt tttttttttg agacagagtc ttgctctttt
     9361 gcccaggctg gagtgcagtg gtgtgatcat ggcttgctac agcctcaaac tcttgggctc
     9421 aaacaatcct cccacctcag cctcctgtgt aactgagacc acaagcaccc acaatcatgc
     9481 ccagctgatt tttttgtatt tttggtagag aaagggtttc accatgttgc ccagcctggt
     9541 ctgcaactcc tgaactcaag cgatctgttc gcctcagcct cccaacgtac tgggcttata
     9601 ggcatgagcc accgcgctcg gcccccacta gtcctttaac ctcctatctc cctgggaaat
     9661 atataatagt aatagccacc gggcgcggtg gctcacgcct gtaatcccag cactttggga
     9721 ggccgaggtg ggtggatcac gaggtcagga gattgagacc atcctggcta acatggtgat
     9781 actctatgtc tactaaaaac acaaaaaatt agccaggtgt ggtggcgggc gcctgtagtc
     9841 ccagctactt gggaggctga ggcaggagaa tggcgtgaac ccgggaggcg gagcttgcag
     9901 tgagccgaca ttgtgccact gaactccagc ctgggagaca gactctgtct caaaaaataa
     9961 ataaataaat aaataaataa ataaataaat aaataatagt aatagtcaac atatctttag
    10021 gaggcagcaa aataggataa cttttggcaa attccttaat cttttttttt ttttcgagac
    10081 agagttttgc cccgttgccc aggctggaat gcagtggcat gatcttggct cactgcaacc
    10141 tccacctcct gggttcaagc gattctcctg cttcagcctc ctgagtagct gggattacag
    10201 gtgcccacca ccatgcctgc ctaatttttg tagttttagt agagatgggg tttcactatg
    10261 ttggccaggc tggtctcgaa ctcctgacct cagtgatcca cctgcctcag cctcccaaag
    10321 tgctaggatt ataggcatca gccaccacac ctggccaaat tccttaatcc ctatgtgtct
    10381 cagtttcctg atctggaagt gggccaacca ttgtccctac cgcctagaat tattttgagg
    10441 attgacagag ttaatagaac tatgcctggc acccagtaag ttctatgtaa gcactgggtt
    10501 ttgggttgtt ttttgttttt cttttttgaa cacttgctat aaggtaattc atttaacatg
    10561 gtacatgtac taattctaaa ctttacaaca atcctgtgag gtaagtaacg aattgtcatt
    10621 ctcattttac agtggaggat aaagaggctg aaggagttta agtcatttgc ctgaaatcat
    10681 tacacagtta gagaggggca gtgttgcaat tccaacctgg gtcagtggca gtctgattca
    10741 gagacctgat atccttagct ctggtattca aaacatgctt tcctcctctc tgccatcaaa
    10801 tcctttgtct aaagaaggaa agcaggctgg gcgtggtggc tcacacctgt aatcccagca
    10861 ctttgggagg ctggggctgg tggatcacct gaggtcagga gtactcaaga aacagaaagg
    10921 aggccagtag aactgaatga agtaagcaga ggggaaagca gtaggagatg aagtcaagga
    10981 gctcatggga aggacctata gaccataacc agctgcgttt caaagggact ctagacccag
    11041 gaaggcccag aaccactgat gctgagtaac acccttggcc ttctggtctg agttgctatg
    11101 gccttgggca tgctagaaca ggcaagtgag tttcactggg gcatgtgttg ggtggatgtt
    11161 tcaggttctt ttcttttctt ttcttttctt tttttttttt ttttttttga gacagagtct
    11221 tgctctgtct cccaggctgg catgcagtgg cgcgatctcg gctcactgca acctccacct
    11281 cccaggttca agcaattctc ctgcctcagc ctccctcccc ggtagccggg attacagaca
    11341 tgagccacca tgcctgagta atttttctat ttttagtaga gatgggattt ctccatgttg
    11401 gccaggctag tctcaaactc ctgacctaaa atgatccacc cgccttggcc tcccacagtg
    11461 ctgggattac aggtgtaagc caccccgccc agcctgttat gttttttaac gttggtcttt
    11521 cggccaccaa gagcccagga aggccacatg cacagctctg ccaggtgcag cccaggtgtc
    11581 cagggctctc tggtccagga caccatggcc tggtgtgccc ttatctccag gcctgaagcc
    11641 ccacctgtcc aacctggaga cagctatgca aggttctctt gccaggtgct gtttaatctt
    11701 gggccctcca gggcctggag cagcttccag ggcccgtcct ccatgccccc acccaaggac
    11761 gtcctcactc cagcaagctc agctacatgc tcagcagtca gggccactga ggccacagcc
    11821 ccgccgccac ccacaccagg ctgtcctaga gggccacccc agccctggaa gccccctcaa
    11881 cccctgcttt catgcaggag agggggagcc actggaaggt tctggaaaga ggaataatat
    11941 gatctgattc tatttctttc tttccttttt cttttttttt ttttttttag atacagtccc
    12001 tgtctgtcac ccaggctgga gtgcagtggc acgatcttgg ctcactgcaa cctccgcctc
    12061 ccgggttcaa gcgattattc tgcctcagcc tcccgagtag ctgggattcc agtcacacac
    12121 cacgatgccc agctaaattt tttgtaattt aagtagagat ggggtttcgc tatgttggcc
    12181 aggctggtct cgaacttctg acctcaggtg atctgaccgc ctcagcctcc caaaatgcta
    12241 ggattacagg catgagccac cgcacccagc ttgatttata ttttaacaaa atcagtctgg
    12301 ctgctcggtt gagaacagtc agcatgggag aaaaggatgg agcaaagaga ccagttagga
    12361 gggctttaca ataattcaga cctaaggtaa tgtgctttag agcaaggtgg tgatgtagga
    12421 ggtgggactc gactccagac caaattgagg accagctaga acaggaacag ggcagatgca
    12481 gctttccata agacatactc acgagtgtgc catgtcagtt taccattgcc atggaaacac
    12541 ctgggagtta ccaccccttt ggcaatcacc tgatgacaca gaagttactg ccctttccct
    12601 agaaatttct gcctaatccg ttgcttaatc tgcatgcaat taaacgtagg tataggccag
    12661 gcgtggtggc tcacgcctgt aatcccagca ctttgggagg ctaaggtggg cagatccctt
    12721 aaggtcagga gttcaagacc agcctggcca acatggtgaa accctgtctc tactaaaaat
    12781 acaaaaagtt agccaagtgt ggtgccatgc acctgtaatc ccagctgctc gggaggctaa
    12841 gacaggagaa ctgcttgaac ccaagaggca gaggttgcag tgagctgcaa tcacgccact
    12901 aaactccagc ctgggtgaca gagtgagagt ctgtctaaaa ataaataaat acataagaga
    12961 tagggaagac tatcagagga gtagctttgg tagtaagata atttagtttt ggacattttg
    13021 ttttattttg tttctgcttt tgttttttga gatggagttt tgctcttgat gcccaggctg
    13081 gagtgcaatg gcacgatctc gactcactgc aacctctgcc tcctgggttc gagtgattct
    13141 cctgcctcag cctccctagt agctgggact acaggcaccc accaccatgc ccagctaatt
    13201 ttttgtattt ttagtagaga tggggtttca ctatgttggc caggctggtc tcgaacccct
    13261 gacctcaggt gattcgcctg cctcggcctc gcaaagtgct gggattacgg gtgtgagcca
    13321 ctgtacccgg ctcagttttg gacatgttaa gcttgaaata tttattagac atccaactat
    13381 ccaagagagg ttgagtaggc agatggatat atatctggca ttcaggggag aagtccaggg
    13441 tggacataca aatgtaggaa tgatttacat gcagatggcc cttccaaaag cctgtctttt
    13501 tttttttttt ttttttttta tgatggagtt ttgctctgtt gctcaggctg gaaggcagtg
    13561 gtgccatcac agctcactgc agcctccatc ttccacactc aagcagtcct cccaactcag
    13621 cctctcaaat agttgggacc acaagcatgc gccattgtgc ctggctaatt tttttttttt
    13681 tctttttgta gaggttgggc aaagtggctc acgcctgtaa tcccaacagt ttgggaggcc
    13741 aaggtgggtg gatcacttga gctcaggagt ttgagaccag cctgggtaac atggtgaaat
    13801 cctgtctcta caaaaagtac aaaaattagc tgggcatggt ggcgtgcacc tgtagtccca
    13861 gctactcagg aggccgaggt gggaagacca cttgagcctg ggaagtggag gtttcaatga
    13921 gccattatca tgccactgca ctccagcctg ggtgacagag caagacccag cctcaaattt
    13981 gtttttgtag aaaagaggtc tccctatgtt gctcaggctg gtctgaaact cctgggctca
    14041 agcaatcctc ccaccttggc ctcccaaagt gccaggacta caggtgtgaa ccactgtgcc
    14101 tggctgtaga aatctgtctt tgaatggcct ggaaacatgg tcactgatta tgccatagag
    14161 ctttccttca ggcaagtcta atccttctct cttcccctct gccctccaag gagagaagat
    14221 ggggctctca atctttgccc tgctgaccct tactgtgttc ctgctgctgc tggctgacaa
    14281 agtacctgag acctcactat cagtacccat tattatcaag tacctcatgt ttaccatggt
    14341 cctcgtcacc ttctcagtca tccttagtgt cgtggttctc aacctgcacc accgctcacc
    14401 ccacacccac caaatgcccc tttgggtccg tcaggtaaga aagatctcct cctccaaccc
    14461 caattttcct tttacagacc atagggagaa ctatagctat gtggcagagt gttgaagtgt
    14521 ccaagcttgt tgagtgttga aatgttgcac agttaagcta gcccccatca ttatcatttc
    14581 acagatccca tactctcttc atcaatactg cccatctcgg gtcccaggga aatattctta
    14641 gggttaggta ctatcagatt ggaagccctc tctttccagt tgggatacct cccaacccac
    14701 taaatagctt tttttttttt tttttttttt ttttgagatg gagttttgtt cttgtggcca
    14761 ggctggagtg caatggcaca atctcagctc actgcaacct tcacctccca ggttccagcg
    14821 attctcctgc ctgagcctcc caagtagctg ggattacagg cacccgccac cacgcccagc
    14881 taatttttgt atttttagta gagagagggt ttcaccatgt tggccaggct ggtcttgaac
    14941 tcctgacctc aggtgatcca cctgccttgg cttcccaaag tgctgcgatt acaggcgtga
    15001 gccaccgcga caggcccaac ccactaaaga gctcttaggt ctgtgtggct gcatttcctt
    15061 gtgtagctcg tttgtggaag aatatgcacg cacatactca cgcgcgggaa tgggcatgtg
    15121 gagtggggtg gttggctgtt tcccttctgg tctgaaagca tgaaagcccc caccaatacg
    15181 cctcttctac tctgcagatc ttcattcaca aacttccgct gtacctgcgt ctaaaaaggc
    15241 ccaaacccga gagagacctg atgccggagc cccctcactg ttcttctcca ggaagtggct
    15301 ggggtcgggg aacagatgaa tatttcatcc ggaagccgcc aagtgatttt ctcttcccca
    15361 aacccaatag gtaggactac gcccgttacc cacataagag ggagagggag aactacagtt
    15421 cccagaagag tgtgcggaag aagcggccca tgctctcgga agacgctgtg gttgagcatc
    15481 atgggagttg tagtactcct gctgctcact ttgaggggag gtgggaacta aaacagaggc
    15541 ggtggaagaa gttgcacaag gctagagaga tcactgctgg agggaaaagc atgatgggct
    15601 ctcgggtttt gagaactggc aagttgttgg aggcagctgg agcggggcct gggtcgccgg
    15661 cactggctgt ctttgcgttt gggcgtggcc agtcactcct cttccaggtt ccagcctgaa
    15721 ctgtctgccc ctgatctgcg gcgatttatc gatggtccaa accgggctgt ggccctgctt
    15781 ccggagctac gggaggtcgt ctcctctatc agctacatcg ctcgacagct gcaggaacag
    15841 gaggaccacg atgcggtatg tccaacgggg gtggaacaag gccaggtcta ggcgaccttg
    15901 gccccacccc caaattccgc accagcactc gctttcgttt tttttgtgtg gttttttttt
    15961 ggcttttttt tttttttttt ttttttgaga cagagtctcg ctctgtcgcc caggctggag
    16021 tgcagtggct cgatctcggc tcactgcaac ctccgcctac gggttcaagc gattgtcctg
    16081 cctcagcctg ccgagtagct gggacgacag gggcgcgcca ccacgcctgg ctaatttttg
    16141 tatttttagt agagacgtgg cttcaccatg ttggccaggc tggtctgaaa ctcctgacct
    16201 caggtgatcc gctcgcttcg gcctcccaaa gtgctgggat tacaggcgtg agccaccgcg
    16261 cccggcctcg ctttcgtttc tgattggacc tctccctcat ttggtcccac cccctgctta
    16321 cctactggtt ctttatgccc atgcattgcc tgcagtctcg ctctcctgtt ggcgctgccg
    16381 gctgttgcct caaaccagtg gtaggaggac tcaagcgggt agcgggcggg gaaatggggg
    16441 ggtttccctg ggggtctggg cccagagctc aggaagtttc ctttgcctac ccacagctga
    16501 aggaggactg gcagtttgtg gccatggtag tggaccgcct cttcctgtgg actttcatca
    16561 tcttcaccag cgttgggacc ctagtcatct tcctggacgc cacgtaccac ttgccccctc
    16621 cagacccctt tccttgaaga ctggagggtt gagacccagg ccccctgcca gttgaagtga
    16681 gagtttggtg atactgtcaa gccctatcct tctctgcctc ttaactcctt cacgaggaat
    16741 ctgggcctct tatttcgttt ctggggactg cattggactg agggctgggt aggcaggtgt
    16801 cttggaccca cctgaaatgc agtatcatct gatttactct ttgggatctt gaagaagctc
    16861 ttttgggtat caacacctag gtcgccagtg aaatagaaca cagaacagga actagattat
    16921 aagccttatg aggtcaagaa atgtgacttg gccgggcgcg gtggctcacg cctgtaatcc
    16981 cagcactttg ggaggccaag gcgggcggat cacctgaggt cgggagtttg agaccagccc
    17041 gaccaacatg gagaaaccct gtctctacta aaaatacaaa attagccagg tgtggtggta
    17101 catgcctgta atcccagcta ctagggaggc tgaggcagga gaatcactcg aacccgggag
    17161 gcagaggttg cagtgagtca agatcacgcc attgcactcc agcctgggca acaagagcga
    17221 aactccatct caaaaaaaaa aaagtgtctt gttcactgca gcatgcccag tgccacgcac
    17281 aggtgctgac ctatagtaag tgcttaacat ttgttgaata ggggaaagaa atttccggaa
    17341 gtaaatacag caattaataa tgtttataag ctgggcatgg tcgctcaggc cagtaatccc
    17401 agtgacttag gaggctgagg tgggaggatt acttgaaacc cacagtttga gaccagcctg
    17461 ggcaacatag tgagaccctg tctctaaaaa aataaaaata gaaataaagt agtgcttatt
    17521 gtttgcatgt tgggtcttgt ggtcgttttc tttttacctt tctgtaattt attatgtttt
    17581 gtaatgtgta ctatctctgg gattaaaaaa agttatttct acaagcatgc attggtaatg
    17641 agaaaaaaca agcgttttga aggccttcat tcaagttcca accttggtgc tcacacaagc
    17701 cactagcttg ctctgtactt gtttcgacat ctgtaaaatg aaactaatga tagcatatgc
    17761 cctataggat tgtctgggga tcacaggaga tgggaaaaaa gcactatgcg atatgtatca
    17821 gaggttgcaa cggtgtgttt tttgtttggc ctgcacagtt ttaaatttga actagttcac
    17881 tacttttatt ttttattttt tttcaagaca gagtctcgct gtgttgccca ggctggagtg
    17941 cagtggcggg acctcggctc accacaacct ctgcctcccg ggttcaagtg attctcctgg
    18001 ctcagcctcc tgagtacctg ggactgcaga cccacaccac catgcccagc taatttttgt
    18061 acttttagta gagatggggt ttcactatgt tggccaggct ggtctagaac tcctgacctc
    18121 gtgatctgcc cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc catcacgcct
    18181 ggctactagt tcactgcttt taaaatgtgg atatttcatg agaaatttgg cttcctggct
    18241 tctcttgaaa ataatcttat ttaaaaaaaa actatagaga cagggtctca ctatgttgcc
    18301 caggctggtc ttgaacttct gagctcaagt gatccacctg ccttggcctc ccaaaatgct
    18361 gggattacag gtatgagcca tcacacccag cctcaaagat aattttaaaa actatagtag
    18421 tccgggcgtg gtggtttatg cctgtaatcc cagcactttg ggaggctgaa gcaggcagat
    18481 cacgaagtca ggagttcgaa accagcctga ccaacatgct gaaaccccgt ctctactaaa
    18541 aatacaaaaa ttagctggat gtggtggcgt gcacctgtaa tcccagctac tcaggagcct
    18601 gaggcaggag aatcgcttga acctgggagg tggaggttgc agcgagccaa gatcgtgcca
    18661 ctgcactcca gcctgggcaa caagagcgaa actccatctc aaacaacaac aacaacaaaa
    18721 aactatagta acaccaggcc tgattcccct gttggcaaca acttgtgtag agcttagtgg
    18781 ctgccactct ggtcaagtta ttcataccat aattcctcaa agcccctgta aacctgaccc
    18841 acgtcactta gtttacctgc ccatccctcc gtaacactag aaaagataca gggggcaacg
    18901 aattgaagcc aatggggaag ccacaagtgg aaaaagaaag gttgtgtctc ttatggccat
    18961 cacacatttt atgcctcagt tttctttcaa tttggaagga aggttagacc tggtttaagg
    19021 cagggccatt ttggacatag agatctcgcg cccagcaggt tgtatgaact agactgttaa
    19081 tatttctggc tggatgttgg gccaaagtca gcttgagcct acagtcaaca agccctcact
    19141 caactactca actgctggaa gttgcgtcca aacagggagc attgggccac aactcacagg
    19201 gatccttgtg ggacaaagtt agcatgttcc tttcccccag acccaccagc cacgcaaata
    19261 attgcacctg gcatcccact gtggagcaca gttcatttgt cttgttggtt tattggccta
    19321 cagagttgga cacacacaca aatgcggaga taaatattgg tcagtttctc taaatctggg
    19381 tcctcactac gtatagagct agtctgtaga attctaaatt ttgcgtgctg cggcacagaa
    19441 ccagtggcct tctcactctg ccaccacccg tcttcccagg gaacatgggg aaagagggca
    19501 cgaactgaca agacttgatc attttca
//

