LOCUS       NG_029213              11042 bp    DNA     linear   PRI 01-FEB-2012
DEFINITION  Homo sapiens choline kinase beta (CHKB), RefSeqGene on chromosome
            22.
ACCESSION   NG_029213
VERSION     NG_029213.1  GI:338827772
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Johan den Dunnen. The reference sequence was
            derived from U62317.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Choline kinase (CK) and ethanolamine kinase (EK) catalyze
            the phosphorylation of choline/ethanolamine to
            phosphocholine/phosphoethanolamine. This is the first enzyme in the
            biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all
            animal cells. The highly purified CKs from mammalian sources and
            their recombinant gene products have been shown to have EK activity
            also, indicating that both activities reside on the same protein.
            The choline kinase-like protein encoded by CHKL belongs to the
            choline/ethanolamine kinase family; however, its exact function is
            not known. Read-through transcripts are expressed from this locus
            that include exons from the downstream CPT1B locus. [provided by
            RefSeq, Jun 2009].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11042             U62317.2           52455-63496
FEATURES             Location/Qualifiers
     source          1..11042
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            complement(4073..4974)
                     /gene="LOC100144603"
                     /note="uncharacterized transcript"
                     /db_xref="GeneID:100144603"
     misc_RNA        complement(join(4073..4402,4677..4974))
                     /gene="LOC100144603"
                     /product="uncharacterized transcript"
                     /transcript_id="NR_021492.1"
                     /db_xref="GI:178057352"
                     /db_xref="GeneID:100144603"
     gene            5001..>11042
                     /gene="CHKB-CPT1B"
                     /gene_synonym="CHKL-CPT1B"
                     /note="CHKB-CPT1B readthrough (non-protein coding)"
                     /db_xref="GeneID:386593"
                     /db_xref="HGNC:41998"
     gene            5001..9042
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /note="choline kinase beta"
                     /db_xref="GeneID:1120"
                     /db_xref="HGNC:1938"
                     /db_xref="MIM:612395"
     mRNA            join(5001..5442,5643..5751,6138..6251,6447..6580,
                     7340..7435,7584..7642,7729..7810,7918..8026,8170..8273,
                     8493..8574,8745..9042)
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /product="choline kinase beta"
                     /transcript_id="NM_005198.4"
                     /db_xref="GI:242246959"
                     /db_xref="GeneID:1120"
                     /db_xref="HGNC:1938"
                     /db_xref="MIM:612395"
     exon            5001..5442
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(5219..5442,5643..5751,6138..6251,6447..6580,
                     7340..7435,7584..7642,7729..7810,7918..8026,8170..8273,
                     8493..8574,8745..8819)
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /EC_number="2.7.1.32"
                     /EC_number="2.7.1.82"
                     /note="ethanolamine kinase beta; choline kinase-like
                     protein"
                     /codon_start=1
                     /product="choline/ethanolamine kinase"
                     /protein_id="NP_005189.2"
                     /db_xref="GI:6978649"
                     /db_xref="CCDS:CCDS14099.1"
                     /db_xref="GeneID:1120"
                     /db_xref="HGNC:1938"
                     /db_xref="MIM:612395"
     exon            5643..5751
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            6138..6251
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     exon            6447..6580
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     STS             6607..6877
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /standard_name="STS-T55238"
                     /db_xref="UniSTS:43089"
     exon            7340..7435
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     exon            7584..7642
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     exon            7729..7810
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=7
     exon            7918..8026
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=8
     exon            8170..8273
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=9
     exon            8493..8574
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=10
     exon            8745..9042
                     /gene="CHKB"
                     /gene_synonym="CHETK; CHKL; CK; CKB; CKEKB; EK; EKB;
                     MDCMC"
                     /inference="alignment:Splign:1.39.8"
                     /number=11
     gene            9333..>11042
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /note="carnitine palmitoyltransferase 1B (muscle)"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     mRNA            join(9333..9451,10066..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /product="carnitine palmitoyltransferase 1B (muscle),
                     transcript variant 2"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_152245.2"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_152245.2"
                     /db_xref="GI:223468668"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     mRNA            join(9333..9451,10066..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /product="carnitine palmitoyltransferase 1B (muscle),
                     transcript variant 5"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_001145134.1"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_001145134.1"
                     /db_xref="GI:223468669"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     mRNA            join(9333..9451,10066..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /product="carnitine palmitoyltransferase 1B (muscle),
                     transcript variant 6"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_001145135.1"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_001145135.1"
                     /db_xref="GI:223468671"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     mRNA            join(9333..9451,10066..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /product="carnitine palmitoyltransferase 1B (muscle),
                     transcript variant 7"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_001145136.1"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_001145136.1"
                     /db_xref="GI:223468673"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     mRNA            join(9535..9614,10066..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /product="carnitine palmitoyltransferase 1B (muscle),
                     transcript variant 1"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_004377.3"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_004377.3"
                     /db_xref="GI:311213909"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     mRNA            join(9535..9614,10066..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /product="carnitine palmitoyltransferase 1B (muscle),
                     transcript variant 3"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_152246.2"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_152246.2"
                     /db_xref="GI:311213910"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     mRNA            join(9923..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /product="carnitine palmitoyltransferase 1B (muscle),
                     transcript variant 8"
                     /inference="similar to RNA sequence, mRNA (same
                     species):RefSeq:NM_001145137.1"
                     /exception="annotated by transcript or proteomic data"
                     /transcript_id="NM_001145137.1"
                     /db_xref="GI:223468677"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     CDS             join(10085..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /EC_number="2.3.1.21"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_004368.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform a is encoded by transcript variant 1;
                     carnitine O-palmitoyltransferase I, mitochondrial muscle
                     isoform; carnitine O-palmitoyltransferase 1, muscle
                     isoform; carnitine palmitoyltransferase I-like protein"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, muscle
                     isoform isoform a"
                     /protein_id="NP_004368.1"
                     /db_xref="GI:4758050"
                     /db_xref="CCDS:CCDS14098.1"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     CDS             join(10085..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /EC_number="2.3.1.21"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_689451.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform a is encoded by transcript variant 2;
                     carnitine O-palmitoyltransferase I, mitochondrial muscle
                     isoform; carnitine O-palmitoyltransferase 1, muscle
                     isoform; carnitine palmitoyltransferase I-like protein"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, muscle
                     isoform isoform a"
                     /protein_id="NP_689451.1"
                     /db_xref="GI:23238254"
                     /db_xref="CCDS:CCDS14098.1"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     CDS             join(10085..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /EC_number="2.3.1.21"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_689452.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform a is encoded by transcript variant 3;
                     carnitine O-palmitoyltransferase I, mitochondrial muscle
                     isoform; carnitine O-palmitoyltransferase 1, muscle
                     isoform; carnitine palmitoyltransferase I-like protein"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, muscle
                     isoform isoform a"
                     /protein_id="NP_689452.1"
                     /db_xref="GI:23238256"
                     /db_xref="CCDS:CCDS14098.1"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     CDS             join(10085..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /EC_number="2.3.1.21"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_001138607.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform a is encoded by transcript variant 6;
                     carnitine O-palmitoyltransferase I, mitochondrial muscle
                     isoform; carnitine O-palmitoyltransferase 1, muscle
                     isoform; carnitine palmitoyltransferase I-like protein"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, muscle
                     isoform isoform a"
                     /protein_id="NP_001138607.1"
                     /db_xref="GI:223468672"
                     /db_xref="CCDS:CCDS14098.1"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     CDS             join(10085..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /EC_number="2.3.1.21"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_001138609.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform a is encoded by transcript variant 8;
                     carnitine O-palmitoyltransferase I, mitochondrial muscle
                     isoform; carnitine O-palmitoyltransferase 1, muscle
                     isoform; carnitine palmitoyltransferase I-like protein"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, muscle
                     isoform isoform a"
                     /protein_id="NP_001138609.1"
                     /db_xref="GI:223468678"
                     /db_xref="CCDS:CCDS14098.1"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     CDS             join(10085..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /EC_number="2.3.1.21"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_001138606.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform c is encoded by transcript variant 5;
                     carnitine O-palmitoyltransferase I, mitochondrial muscle
                     isoform; carnitine O-palmitoyltransferase 1, muscle
                     isoform; carnitine palmitoyltransferase I-like protein"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, muscle
                     isoform isoform c"
                     /protein_id="NP_001138606.1"
                     /db_xref="GI:223468670"
                     /db_xref="CCDS:CCDS46734.1"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
     CDS             join(10085..10225,10537..10676,10966..>11042)
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /EC_number="2.3.1.21"
                     /inference="similar to AA sequence (same
                     species):RefSeq:NP_001138608.1"
                     /exception="annotated by transcript or proteomic data"
                     /note="isoform d is encoded by transcript variant 7;
                     carnitine O-palmitoyltransferase I, mitochondrial muscle
                     isoform; carnitine O-palmitoyltransferase 1, muscle
                     isoform; carnitine palmitoyltransferase I-like protein"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, muscle
                     isoform isoform d"
                     /protein_id="NP_001138608.1"
                     /db_xref="GI:223468674"
                     /db_xref="CCDS:CCDS46735.1"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:2329"
                     /db_xref="MIM:601987"
ORIGIN      
        1 atctcggcac aggctcaggg ggccgccatg gtgtcagaga aggcctggag caggaagtgc
       61 aaagacacac agcagagatg cagctctgtg tccactgcag ttaaaggtgg gctgagggca
      121 tcagccaaga caccatctcc tgcccctctc agatctagtc agctacaata ttgagtctac
      181 tctgtcacga ttcttcaaag taaaggctag ttacaactcc tatgaaagcc ttaatacaag
      241 aggcttagca gaacaaatac aatccccact gccacagctt ctcccaagta acagatattc
      301 agcagccacc tcctccttgg cctcaccctc accagcattc cagcttgtct ccatggcttg
      361 cctggtgacg ctgcccagac cttcaccctg aggcatctga gcccttaggg gctatggctg
      421 ctgaaaagac cttttcattg tcattacttg gcatggaagc accaagacag acctagatga
      481 atcctctaag tgccagatca atgcctgctt gccccgttac gcagcagcca cgctacctcc
      541 tcaccgttta tcaggatcaa gtatcccctc ctttgtggcc tgctggtcca ccagtatgag
      601 gagctgagag taacctggtg gtctttgcag attcaggctc agcagaggta tccttcctgc
      661 aaccagcagg agtgccctcg tggaagcgtt cctacctggg aaacaggctc taatccagca
      721 gatcctaagg ctgtggagac agaatgtaca aattctacgt gtaagcactg ggaatgatgg
      781 tgagaagtag ctaatcccaa cccttgggtt cctggacctg tgtctttctg cttggatcca
      841 catgaagtat ctactggggg cagagcacca tatattagac tctgattcag tgtatatatc
      901 ccaactcctc aggatactgt cctagaacca ggacctcagc taagccctta agaagtcatc
      961 ccatctttcc agtagcctag ctgcttttac gtaacgcagg atattagaga agcagtggat
     1021 cccatggtca tccacacact accatacctc tttcgctata aaatggcttt cttggcctga
     1081 ggcgatgtga ttcgtgatcc catgttggta cacggagcat gcctgaagct cctggatagt
     1141 gatgctggcc tgggaccctg tggatacaga agacaaaccc ttatccagag caggtgtcaa
     1201 ctccagcaag gatgaagggc tgtcaccaac ttgccactaa gtaactagtt ggggtgctct
     1261 agggatggta tctcagcagg ggctcagcac tgatcgcttt cagcaggagt aatcatgaga
     1321 caagccttga gaaagaaggc ctgtgctggt ggacgctaac ctgtgctcct tctgcatgac
     1381 gccgccactc acagtccact gttcaagcac aggggtagcc aggggcacag ctgactgaca
     1441 tcccatccat cctgctgttc accaactcct ctgcagtatt aacacaaggc agagagatgc
     1501 acatattgtg tggccactcc tgtaggtcca tcttcccctc ttgctctttt caggtccctg
     1561 accagccagc aggacgtcac aacccagaag tccatatgcg tccctccctc aggccactac
     1621 tctgtccact gcctccatac aaagtggata tccacacgaa ctgctggaag ctcagcccca
     1681 tggaggattt cctattgtcg tcctttaggg tcaccttgaa tgggactgta gtgtacctat
     1741 ggttcatttt cagttcatat caacacatca aactgaccta tatacgaacc agaccagaat
     1801 gcttatctgc taagggagaa atatcagtgc aaagcagatg tggggccaca ctgccacctc
     1861 ttcctgtaaa taactgttac ccactagaca cgcttgggtc caagcccaag gcttcctttt
     1921 tcattgtacc atcaattgct actgagcctc tgacctactg acttggagga tctgacaaca
     1981 cctcgcttgg gcagaccctg tcgcatggtc gctgatgtcc caccagcagg tgctcggtct
     2041 ctacctgggt ctggtagtgt gcctgatact gctctcactt ggcgagtagt tctctgctgc
     2101 agaaggcatg gtcttgtcca agaactctag gacagtgtac tgcaactctt ccgttggagt
     2161 ttgccagaga tgccatatag ggtccttcct accccaaata agccccccgg taacccattg
     2221 gatctatgca gcagggaagc ccatctccca atccaaatct ttagcagagc cctctttttc
     2281 tctgggcccc actcaaagct ggcagttttc ccgttaccca ataaaggggt cagagaggta
     2341 tcctctagcg cggtgcatgc tgactccaaa acacagaggt gcctcaatgc tgtgcctctt
     2401 tcttccttgt aaggatgcag gatgcaataa cttgtccctg gcttgccctc aaacgctgca
     2461 cccctgagaa tgtcactgat atggcaggct ccagaacttc tgagggcttc tcgctcatcc
     2521 tctgacatgc acggccttct tcaccatgtc caactagtat gacatcatca atgttatatg
     2581 gaatatagat gataagctac ctaaggacta ttgtgacaga gaacaggaga gttcagacag
     2641 caagaagcaa gaccatttac agagctgtcc ttcccatata aatgtgaact gcttttaatc
     2701 ctctttacca ctggcaattg aaaagaatgt tcaccaagtc aataattgca ttatcaagag
     2761 ccagaggtgc atttatcggt tccagtaaag ataccacacc tagcacagct gtgtgatcgg
     2821 ggacacgact tggctaagtt tgtgcagggc atcatcattt acttgaatcc accaagattt
     2881 agcaggagcc attcaggtta attgaaggga tgaaacggta accactgctt tataagtctt
     2941 tgagggcgaa atacctctgc aattacacct ggaatgcagc attgtttctg acttactatc
     3001 ttggaaaggt ttcagtaggg tgaggagttt caaaggtttc tactttgcgc ttccttacat
     3061 atggtaccaa aggcctggga tcaatgtata cgctccgccc tctgctaggt aaaaacatcc
     3121 caagtatgca ttgagaccag agaagtaacc acaggactcg ggttgggaat tctgcttatc
     3181 atctgatttc cataagcctg caccctaatg agagggccat gatgcttcag ggctcctgga
     3241 aacagtgtca gctcagatcc tgtatcagcc cttcaaagac ctagacagtc ccttttccga
     3301 agtaaactag tttttttggt gtgtttgttg ttgctgttca gacagtcttg ctgtgttgct
     3361 caggctggag tgcagtggcg tgaacacagg tcactgcagc cttgacctcc tgggcttaag
     3421 tgattctctc acctcagcat ccagagtagc tggaaccaca ggcacctgcc accacgccca
     3481 gctaatcttt taatttttgt aaagacaggt tcttgctatg ttgcccaggc tggtctcaaa
     3541 ctcctgggct caaacgatcc tcctacttcg gcttcccaaa gtgcagggat taaaagcgtg
     3601 acccactgcc cccagccaga atcagttttc tttttttttt tttttttttt gagactgagt
     3661 ctgactctgt cgctcaggct ggagtgcagt ggctcgcggc aacaaggcct gggttcaagg
     3721 gattgtcacg cctcagcctc ccgtgtagct gggattacag gcacaagcca ccaaacccgg
     3781 ctaatttttg tatttttagt agcgacgggg tttcgctatg ttggccaggg tggtctcaaa
     3841 ctcctgacct caagtgatct gcccgcctcg gcctcccaaa atgctgggag tacaggcgtg
     3901 agccaccacg cccggaccag ttacttttta aagtggctct aggtcccttt agggaaggat
     3961 tggaggaata tttcttggta tatgctcaga tgctggtatt gtaagatcct tcctgagagg
     4021 aaccaagcct ccttgtcaat taatgggctc taggtctcaa aactgactca gatttaaaca
     4081 gaatgatcat gattttccac tgcagcaaaa gtgacattag ccttgtgatc accaattttt
     4141 gatttctttc tggttatcaa acaatactct agtcagatgc cccaaagaac accatggttc
     4201 gacagacatt gccacagatc tctgtgggtc cagcgttcct ggtcgccgct ctagcctggg
     4261 gcagaagcag aaatgcagga ggcacgcgtt taaatcagga cgccctcaat gggaggtgcg
     4321 caggccgagg agggggctgc ggcaagctgc gagtcttcac tttcttcggc tcttgggttt
     4381 gactctgtaa ttggttctag gcctggagga gacgaggagg atagggggag aggggaatga
     4441 atgaagacgc gcatctcaag cggggcagca aaagactcct cattcagagg tgcggctcta
     4501 ccggccaggg agtccccgtg tagactgggc atttatgcaa ctggagtcat cggaactgtc
     4561 ccaagggtca cattccttca gcaaatgttt actgcgtacc caccgggtgc ccgcatcccg
     4621 cactctgccc gcgctgtgcg gccctgccta gcgcgcgcgc ctcctccagg cctcacccac
     4681 gctcaggacg gacgcgcgct ggacggctct tccttgtcgg agcgccccag gggtcgggga
     4741 agagggcccg gcaagggagc cctcgcgccg gagctgcagc tgcagccgcc gccccgccgc
     4801 cccgccggct cccacggggc agagacgcag ctcctctccg gtcttcccgt acgctaccgc
     4861 gcccgggcag ttcctcgccc gcgcacgcgc cgctccgcca actgattggc ctccggcgcc
     4921 tcggattggc ccaggccgtc caacagcagc cccgcccaga gagagaccat tggtccttgc
     4981 ccataggggc ggggcccggc agagatctgc ggaattcggc cttcggaaag agcccccggg
     5041 ccggggcacg gagagagccg agcgccgcag ccgtgagccg aatagagccg gagagacccg
     5101 agtatgaccg gagaagccca ggccggccgg aagaggagcc gagcgcggcc ggaaggaacc
     5161 gagcccgtcc gaagggagcg gagcgcagcc tggcctgggg cccggtcgag cccgcgccat
     5221 ggcggccgag gcgacagctg tggccggaag cggggctgtt ggcggctgcc tggccaaaga
     5281 cggcttgcag cagtctaagt gcccggacac taccccaaaa cggcggcgcg cctcgtcgct
     5341 gtcgcgtgac gccgagcgcc gagcctacca atggtgccgg gagtacttgg gcggggcctg
     5401 gcgccgagtg cagcccgagg agctgagggt ttaccccgtg aggtgggagg tcaggggtca
     5461 gcctctccgg tgcgcggatc ggggtcaggg gtcagccgcg gggccctcag gatgctccat
     5521 gttttcgccc ccctcttgcg cccgcgcctg gggcggggcg gggccggcct ggccgggagg
     5581 gggccggggc cgcggcaggt agggccggcc gcgggctgag cgcgcctggt gtgggtctgc
     5641 agcggaggcc tcagcaacct gctcttccgc tgctcgctcc cggaccacct gcccagcgtt
     5701 ggcgaggagc cccgggaggt gcttctgcgg ctgtacggag ccatcttgca ggtgaggggg
     5761 gtgtgagcgc cgcagcacca gtggctttag ggcctgtcgc ttacgcgatg cgggtagtat
     5821 tgttcccgtt gcgcagttga ggacaccgag gttcacggtc tgagtaacac ctcattacac
     5881 cgaagcctgg gcctgtattc ccagagcttt gggaggctga ggcgagagga tcacttgagc
     5941 acaggagttc gagaccagcc tggacaacat agtgagaccc ccatctctaa ataaaaatag
     6001 accaacgcta aagcctgtgc tccagagcct ccaggcaatt ggatcagaag tcgcagctct
     6061 ggtgggagga aggcgagccc tcatgtgtgt ccctgtgcca ctttgccttg gcccctttgc
     6121 tgtccatcct ttttcagggc gtggactccc tggtgctaga aagcgtgatg ttcgccatac
     6181 ttgcggagcg gtcgctgggg ccccagctgt acggagtctt cccagagggc cggctggaac
     6241 agtacatccc agtacgggcc cagtcctacc ctctcctccc caaggcacct ccacccccta
     6301 accctacccc agtgcccaat gtctgcctcc acatccctca ccccaagtag ggaatttccc
     6361 ccaaaaccct gacttcccct cattgcccca gcccttccca ctcctgcccc agccccatca
     6421 ccaccctgat agcttcctgg gtgcagagtc ggccattgaa aactcaagag cttcgagagc
     6481 cagtgttgtc agcagccatt gccacgaaga tggcgcaatt tcatggcatg gagatgcctt
     6541 tcaccaagga gccccactgg ctgtttggga ccatggagcg gtgagtcagg agcctcctca
     6601 gggctcctgt actcctgagc tgaacctcca tgccagcgga tgtgtcgggg gctctatcca
     6661 gccctccact tgagtggatc tgatgtcatg ggctgtcaca gaacaggctt ttaaatgctt
     6721 gccagaggcc acatgcagtg cctcatgcct gtaatcccag aactttggga gccgaggtgg
     6781 gtgaggtggg aggatcactt gagcccagga ggcggaggtt gcagtgagct gagctcatgc
     6841 cattgcactt cagcctgggt gagagcaaga ctctgtctca aaacaccaaa caaaaaaaga
     6901 aaaaagaaat gattgccaag gccaggcacg gtggctcatg cctgtaatcc tagcacttcg
     6961 ggaggctgag gtgagcagat tgcctgagct caggagttca aaaccagcct ggacaacaca
     7021 gtgaaaccct gtctctatta aaatacaaaa aaattagcca ggcatggcag catgcacctg
     7081 tagtcccagc tactcgggag gctgaggcag gagaattgct tgaacccggg aggcagaggt
     7141 tgcagtgagc caagatcgcg ccactgcact ccagcctggg tgacagagca agactccatt
     7201 tcaaaagaaa aaaagaaatg attgccggac aagtcacaca gtgataggag caggggtgca
     7261 gtagtctggc ctgaggggta gataggcgag gggtgggaaa gaatagcaga gccagtgtat
     7321 cctattcttt gggcttcagg tacctaaaac agatccagga cctgccccca actggcctcc
     7381 ctgagatgaa cctgctggag atgtacagcc tgaaggatga gatgggcaac ctcaggtgag
     7441 ggcaggcagg acaaggctaa tggtaatggt gtccgccctt ccagtagttg ctgagggctg
     7501 gtgtcagggc ctggcctgtt agggtggctc tgatcctcct ctagtcactc ctgctcagga
     7561 cccatgctcc catacccctg taggaagtta ctagagtcta ccccatcgcc agtcgtcttc
     7621 tgccacaatg acatccagga aggtaggaga aggcatctga gtctcctaac ccaagatgga
     7681 agagccagag ggctctggag tgagcagaac ctcaccccat tcccccaggg aacatcttgc
     7741 tgctctcaga gccagaaaat gctgacagcc tcatgctggt ggacttcgag tacagcagtt
     7801 ataactatag gtgaggctgg aaagatggct tcccatagat ctgttcccat agggctcttg
     7861 aaaacaggcc agctgcccag ggcatttggg gactgaatgt ccaccttatt ctcccagggg
     7921 ctttgacatt gggaaccatt tttgtgagtg ggtttatgat tatactcacg aggaatggcc
     7981 tttctacaaa gcaaggccca cagactaccc cactcaagaa cagcaggtat gtgggccaga
     8041 ggctggggag caggacccat cctgtgagga aggagggagg tggagtctgg aaggaatggc
     8101 cggaaaggat gttacctggg aaatactcca cagtctcccc aattcctgac tcttggccat
     8161 tgatcgtagt tgcattttat tcgtcattac ctggcagagg caaagaaagg tgagaccctc
     8221 tcccaagagg agcagagaaa actggaagaa gatttgctgg tagaagtcag tcggtgagga
     8281 aggaggggca gggtggggta gggcagagca gaggaaagag ggattgggga agaggcagat
     8341 ttatcaagct gcagggaagg tggctgtgga gagtggagtt aggacagtgg gggagaagtt
     8401 aaaactgtag ggattggcca acctgggtga ggggatccaa gcagtgctag acatgctctt
     8461 gaatgcccct ccttttcctg ccctcccccc aggtatgctc tggcatccca tttcttctgg
     8521 ggtctgtggt ccatcctcca ggcatccatg tccaccatag aatttggtta cttggtaagt
     8581 gaccctgggg atgggaatgc tagctggggg gctggggagc agcagcagcc acactcttcc
     8641 aggaggcctg gggagtcccg ggtggctgtg ggcagcctga ggtggatgta gaatgctggt
     8701 cccacgtctt ctcaccactg tgtggggtgg gtttccttcc ctaggactat gcccagtctc
     8761 ggttccagtt ctacttccag cagaaggggc agctgaccag tgtccactcc tcatcctgac
     8821 tccaccctcc cactccttgg atttctcctg gagcctccag ggcaggacct tggagggagg
     8881 aacaacgagc agaaggccct ggcgactggg ctgagccccc aagtgaaact gaggttcagg
     8941 agaccggcct gttcctgagt ttgagtaggt ccccatggct ggcaggccag agccccgtgc
     9001 tgtgtatgta acacaataaa caagcttctt cttcccaccc tgtcctggcc ctgctgagca
     9061 gcagcagaaa gtaccaaacc gagcagtaca cacaaaggga ctcttcagtg ctctgggatt
     9121 gaaagtggtt agcgttcatg ctgccagttg gggtccccca tccctcccca gtcccctggc
     9181 tgcagcttag aataataaat actaggactt ggggaggagg agagtgatgg gggtatgaag
     9241 acgaccctga ggtggggatg ccgcccggag caccagcgat cccagaacag gcagcagctg
     9301 acacatcggt gaccttttcc ctacatttgg ctatttttag ctctaaagcc accatcctca
     9361 cgagactctg gggcccccca ggctcccaga cctttgagca accttcaccg cacagaaacc
     9421 cagccgcgcc ctgcaattcc caccgcggaa ggtgggtggg ttctggttct cgccccacgt
     9481 ttttccccga ccccgatttg ggagtaggtg tcaggttcct ggtgagggcg gggcgggggt
     9541 ggctaggcct gaaggacgtg gggacacggg ccagagtggc tggccccacg cacggacagg
     9601 agtgaacccg agctgtgagt aggggccggc acagggcggc ccgcgggggt ctgggccctc
     9661 agccctgcac aggggcgagg acggcgctgg ggcccgcgcg ctcgggtggg gaagggcggg
     9721 ctcccgaacc ctgcctctgt ccaggccggc tccacttcca ggggcgcctc tctcccctgc
     9781 ccgcgccctc gctgacgccc cccaactcca ggctgccctt cgccgtcctt ggggctcctg
     9841 gagctttcaa ggcccaaatc ccctgcacca cagtggctgt gcccacccgg aaggctggcg
     9901 cgaggatttg gcggcggttg gcctggcggg gggcgcgggc cgggggcagc cgctagtcgc
     9961 ggggtggggg gcgcgagggg tcgcggactg gctgggggcg tctcggcgcg gctggcggcg
    10021 gggccggcct aagcgcgccc gcgcacccat ctgcccccgt cctaggtgcc gaccaacccc
    10081 caggatggcg gaagctcacc aggccgtggc cttccagttc acggtgaccc cagacggggt
    10141 cgacttccgg ctcagtcggg aggccctgaa acacgtctac ctgtctggga tcaactcctg
    10201 gaagaaacgc ctgatccgca tcaaggtgcg cacaggtgct tctcccagag cgtaggcaga
    10261 ggccggctgt cagctgttaa gcgctttgtt agggtccctc actgcctcct tggctggcac
    10321 ttctgcccgg tacaggttgt ggaagtacag acaccagagg ggtgcacagg atgtggtcgg
    10381 acacagggag ctgtgggtgt ggcggaggaa ggagcacagc agggcatcag gagagaaagc
    10441 cttccaggcc aagaccagga gccagttccc aagacttcac aggcaggcta acctcccgcc
    10501 ttccggctcc ataagggcgc ctgtttctgc ccacagaatg gcatcctcag gggcgtgtac
    10561 cctggcagcc ccaccagctg gctggtcgtc atcatggcaa cagtgggttc ctccttctgc
    10621 aacgtggaca tctccttggg gctggtcagt tgcatccaga gatgcctccc tcaggggtaa
    10681 ggagtgaaac tggaagggca caggtgccac cagggagggc tgggcccagc tcccaaggct
    10741 gaggttcctg agctgggcag atacaggaca gcagccattg gcagtcacgg ggcagccctc
    10801 ccctatgaca accattgtct tagccctaca tccgctcatt tgatgcagtc agacatgagt
    10861 gtgcccaggg aggttcttcc ccttggtgtc tcccctgaga cagttcacag ccacccgagg
    10921 ctggcctcaa gaggaccccc tgcagccctt gcccctctcc aataggtgtg gcccctacca
    10981 gaccccgcag acccgggcac ttctcagcat ggccatcttc tccacgggcg tctgggtgac
    11041 gg
//

