LOCUS       NG_008985              35583 bp    DNA     linear   PRI 24-JUL-2012
DEFINITION  Homo sapiens N-acylsphingosine amidohydrolase (acid ceramidase) 1
            (ASAH1), RefSeqGene on chromosome 8.
ACCESSION   NG_008985
VERSION     NG_008985.1  GI:212549766
KEYWORDS    RefSeqGene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124242.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a heterodimeric protein consisting of a
            nonglycosylated alpha subunit and a glycosylated beta subunit that
            is cleaved to the mature enzyme posttranslationally. The encoded
            protein catalyzes the synthesis and degradation of ceramide into
            sphingosine and fatty acid. Mutations in this gene have been
            associated with a lysosomal storage disorder known as Farber
            disease. Multiple transcript variants encoding several distinct
            isoforms have been identified for this gene. [provided by RefSeq,
            Jul 2008].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35583             AC124242.6         177199-212781
FEATURES             Location/Qualifiers
     source          1..35583
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            <1..1607
                     /gene="LOC100133073"
                     /note="family with sequence similarity 175, member A
                     pseudogene"
                     /pseudo
                     /db_xref="GeneID:100133073"
     STS             1805..1899
                     /standard_name="G30051"
                     /db_xref="UniSTS:50999"
     gene            complement(2898..3126)
                     /gene="MRPS18CP3"
                     /note="mitochondrial ribosomal protein S18C pseudogene 3"
                     /pseudo
                     /db_xref="GeneID:359764"
                     /db_xref="HGNC:29744"
     gene            5001..33583
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /note="N-acylsphingosine amidohydrolase (acid ceramidase)
                     1"
                     /db_xref="GeneID:427"
                     /db_xref="HGNC:735"
                     /db_xref="MIM:613468"
     mRNA            join(5001..5323,14412..14458,18609..18699,20121..20207,
                     22701..22779,25468..25542,26769..26814,27576..27720,
                     28259..28313,28541..28622,30296..30427,30535..30658,
                     31108..31164,32376..33583)
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /product="N-acylsphingosine amidohydrolase (acid
                     ceramidase) 1, transcript variant 2"
                     /transcript_id="NM_004315.4"
                     /db_xref="GI:189011545"
                     /db_xref="GeneID:427"
                     /db_xref="HGNC:735"
                     /db_xref="MIM:613468"
     exon            5001..5323
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=1
     CDS             join(5198..5323,14412..14458,18609..18699,20121..20207,
                     22701..22779,25468..25542,26769..26814,27576..27720,
                     28259..28313,28541..28622,30296..30427,30535..30658,
                     31108..31164,32376..32465)
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /EC_number="3.5.1.23"
                     /note="isoform b is encoded by transcript variant 2;
                     acylsphingosine deacylase; putative 32 kDa heart protein;
                     acid CDase"
                     /codon_start=1
                     /product="acid ceramidase isoform b"
                     /protein_id="NP_004306.3"
                     /db_xref="GI:189011546"
                     /db_xref="CCDS:CCDS6005.1"
                     /db_xref="GeneID:427"
                     /db_xref="HGNC:735"
                     /db_xref="MIM:613468"
     exon            5629..6018
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=2
     exon            14412..14458
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=3
     exon            16723..16743
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=4
     exon            18609..18699
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=5
     exon            20121..20207
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=6
     exon            22701..22779
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=7
     STS             22964..23201
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /standard_name="RH11700"
                     /db_xref="UniSTS:18148"
     exon            25468..25542
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=8
     STS             26108..26241
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /standard_name="RH94375"
                     /db_xref="UniSTS:87547"
     exon            26769..26814
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=9
     exon            27576..27720
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=10
     STS             28240..28577
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /standard_name="SHGC-170029"
                     /db_xref="UniSTS:184819"
     exon            28259..28313
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=11
     exon            28541..28622
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=12
     exon            30296..30427
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=13
     exon            30535..30658
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=14
     STS             30545..31157
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /standard_name="D8S1341E"
                     /db_xref="UniSTS:151161"
     exon            31108..31164
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=15
     exon            32376..33583
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /inference="alignment:Splign:1.39.8"
                     /number=16
     STS             32455..32586
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /standard_name="D8S2080"
                     /db_xref="UniSTS:43566"
     STS             33297..33547
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /standard_name="D8S1586"
                     /db_xref="UniSTS:37707"
     STS             33320..33451
                     /gene="ASAH1"
                     /gene_synonym="AC; ACDase; ASAH; PHP; PHP32; SMAPME"
                     /standard_name="D8S2114"
                     /db_xref="UniSTS:27209"
ORIGIN      
        1 aggaaaattg cttgaatccg ggaggcagag gttgcagtga gccaagatcg ggccacctca
       61 ctccaacttg ggtgacagag ctagactcca tctcaaaaaa aaaaaaaaaa gaatagcatt
      121 actgattccc aaatagatga tgctgaagtt gtttatacaa ttgacattca gaaatatatt
      181 ccatgctatc agttttttag tttttataat tcttcaggtg aagtaaataa gcaggcactg
      241 aggaaaatat tatcaaattc acaaaaaatg tggtaggttg ttacaaattc catcgtcatt
      301 cagatcagat catgacattt agagagaggc tgcttcacaa aaacttgcag gagcattttt
      361 caaaccaaga cctggttttt ctgctatgaa caccaagtat aataacagaa agccgctcta
      421 ctcatcgact ggaacatgcc ttatataaac ctcgaaaagg actttttcac agggtacctt
      481 cagtggttgc caatctgggc atgtctgaac aactaggtta taaaactgta tcaggttcct
      541 gtatgtccac tggttttagc cgagcagtac aaacacacag ctctaaattt tttgaagaag
      601 atggatcctt aaaggaggta cataagataa atgaaatgta tgcttcattg taagagaaat
      661 taaagagtat atgcaaaaaa gtggaagaca gtgaacaagc agtagataaa ctagtaaagg
      721 atgtaaacag attaaaacga gaaattgaaa aaaggagatg agcccagatt ccagcagaac
      781 gagagaagag catccaaaaa agaccctcag gagaacattt ttctttgtca aacattatgg
      841 accttttttc cagattctga attcttcatg catgtgttat gtctttaaaa aaacagacat
      901 gtttctaaag gtagctctaa caaccaccac catctcgatg tagtagacaa tctgacctta
      961 atggtagaaa acactgacat tcctgaagct agtccagcta gtacaccaca aatggttaag
     1021 cataaaacct tagacttagc tgacagatgg cagttcaaga gatgacggcg gacggatcac
     1081 gaggtcagga gatcgagacc atcctggcta acacagtgaa accccatctc taatacaaaa
     1141 aaattggctg ggcgcggtgg ctcacgacta taatcccagc actttgggag gccaaggtgg
     1201 gcggatcagg aggtcaggag acagagacca tcctggctaa catggtgaaa ccctgtctct
     1261 attaaaatac aaaaaattag cccggcgtgg tggcaggtgc ctgtagtccc agctgcttgg
     1321 gaggctgagg caggagaatg gtgtgaaccc agaaggcgga gcttgcagtg agctgagatc
     1381 ctgccactgc actccagcct gggctacaga ggaatacttc gactcaggag aaaaaaaaaa
     1441 aaaaaaaaga gtgttcacgg ctgttagaca cacaagacaa accatctaaa acagatactg
     1501 atagtagtaa ccaataaaaa agcatccaaa atgagcagcc cagaaacaga tgaagagatt
     1561 gaaaagatga aggttttggt gaatattcac ggtcacctac attttgatcc ttttaacctt
     1621 aaaaggagat ttttttaatt tggctgatgg gtaaagtcaa acatttccat tgtttttact
     1681 aggttgagct acttgcagta atacaggtaa gttcatttgt ttttactata ttcacctctt
     1741 tgcagtaatc cacagataag tcttagtgca tttattttac aaagtacttt ttcaaacatc
     1801 agatcctttt atttccaaac cttttttcgc ctttcaataa gttgttgagg gaaaggctta
     1861 cacacattct ttagaattgg aaaagtgagg ccaggcacag tggctcacag ctgtaatccc
     1921 agcacttagg gaagacaagg caggaatgat tgaggccagg agttagagac cagcctgggc
     1981 aacacagtga gacccatctc tattaaaaaa aaaaaaaaag tattagaaaa gctagaatag
     2041 ccttattttc acaatgtgga aagaaattta tatgaaattt atctgagtca ttaaaattat
     2101 ccttaggtga taatttttta gaagtacatt acagctagtg ttgccagata aaatgctgga
     2161 tctcacgcag tacctttgca aaacatgatc taaaatttaa atttgtccta catttgtact
     2221 tgctaaatct ggcagcctta attattacac aactataacg caacacaaac aataatctct
     2281 cccctagttt agagtccttt gcacgaaatt tagcaaatcc ttaattttga gtacagtaca
     2341 agcctggtaa tccagtgtgt ttgggatagg ctggtggaac tcagaactga tacatatata
     2401 catacatgtc tatcacattc actgtctatt aggtgtaaat catcttttta tgtaaaagac
     2461 actactggtt tgaggataga gttgtctagg aatgttttgt cctgctgtga cagcatcact
     2521 atgcatccca gtgtaacatt cctacaaagg gaagatctct taaccaggca tacttacatt
     2581 tgctagttag aaaaccattc tgagcagttt taactccatt cagttgaatg gtgtactaca
     2641 ttgtatgagc tatttgtgga ccagatataa atgactatca cccagaacca ctttcattca
     2701 acatatgtaa aatgtgatga gtgttaacat tttaaataag cgatctgctt aatgaacact
     2761 gattggtatg aaggggaagt gtcattcttt acctcactcc tgaaacactt ttctatccaa
     2821 aggttggttt gagtcagtat tggcgtcata caaccactta ctataaaata agtttactgg
     2881 tggtaatgtg atggaattta ttccggatat ctgatgttat aaactttagg gtccctgaaa
     2941 tatgcaggat ccttgtatgt aactggcata aaccctgtaa agagataatt aaagttcttg
     3001 acaaagcata atgagcaaaa tttcagctag ctcaatacag ttgttgaggt gctctttctt
     3061 acccattgtt tgagctctct taattgcttt tgtgatttgt ttcttcccac aaagacctgt
     3121 aaaataaaaa gcttccttat tcataaaaaa gtcaatattt aaagttaaaa aaatgtttat
     3181 ttctcaaact gaaacattat ttctctatct cttgaccttt tagtacacgt ttttgtatat
     3241 tcggttttac taaatcaagt caaacctgtt ccaggtaatg tgatgttata catgataggt
     3301 ttcatttagg gtggggtggc taagttgcaa cccttttaaa tcaaggctcc acctcaggaa
     3361 cctaggaatg ttaggtagga gatgaggaag tccacagctt gccaagaact tcagctattc
     3421 cataaacaat ctgattacat atcccgactc ttgcacacga aacaggttat ccaagtctta
     3481 aacttgatgc ttttgtgcag tatgaaccac cctttccgtg gacataatca tgcatttgca
     3541 catttaaata ccattttcta tgaacagatc agtatgccaa aaaccactgc aaagtctcct
     3601 acacacacct tgccttgact ttctgtacat ttctagtatt aaagaatggt gtaggcaaaa
     3661 taaagatata tgtgtaagaa aaaaaagaca tgcatgaaat ggtttaattt tagggaacta
     3721 gatttatatt ttatctgaaa agagtattaa taatatataa tagacctttg aaagttagac
     3781 gcatagttct gcgaaagtgg tgcctaagaa tagtatgtca attgacaaat tttttccata
     3841 aagaatctga ttttgctaga ctacctaatc accaattaac atcctccagt agggaaaaaa
     3901 atatgcttgg tgacatgttt aaatcgctct caagagtact gaagatgaat gatcttccaa
     3961 tcaagtagct atttgattta gtaataacaa ctaaaagatg ggaatcctct tcttcgcaca
     4021 ctcattttaa gctccaaggt aattccatag attcaacatt taacacgtat attcaatatt
     4081 acacattttt tttccggagt gaaatggctc tgaatgcctt acagaatttg ccctgctctc
     4141 cttaactaaa tactttgtct attaatactt ctttcttctt ttccccttgt tctttctgtg
     4201 ccagacccac acacgtctgc tgtaattgaa catgccaggc acattctcca tttaaagcct
     4261 tttaacagct gctgtctctg cctagaatac tcttacttgg gcacacacaa aactagcttc
     4321 ctggtctccc tcaactgtct gctcaaactt cacctcctta atcatgtcta tctgtccctc
     4381 ttatttaaaa ttgtaactct accacttctg atctccacac ttgatgcccc tggcctccct
     4441 tttcctccac tgcatttgtc actaacatcc cgtataattt tcttaggtat tatgtttatt
     4501 gcccatttct caccgagaac atacgcctca gggtggaaga agtttgtctt tttgttgttg
     4561 ttcactgctt atccccagtg tcaggagaca tgcttggcac attgtaggtc cgcagtaaat
     4621 attttttgaa ttaataaaga atatttctac catctgctag cttactgttc atgcaggagc
     4681 tcaaatgtgc tttaagcatg tgatatgttt caaaagtcaa acttcatcct tagggagaac
     4741 actgtcatct tctcctcctt taaaaaaaaa aaataggaaa aaaagcaaaa caaaacatca
     4801 ccttctcatt tccccacctc caacaaaaag agtgttgagt tttctaaaga aataatacaa
     4861 atggataaaa ctgcaatttg ttgtcctttc tctcacatgc aaaaagaaaa gaaaaaatac
     4921 tgccgagatt tcggcagcgt gctgagcttc atcaaagcat taaaacaatg ctgcttgaga
     4981 cgtcagaggc tcatccagga agtgcaaccc agagggcagg atttcctgct ggactttgaa
     5041 atccaacccg gtcacctacc cgcgcgactg tgtccacgga tggcacgaaa gccaagcgag
     5101 tccccctgcc gagctactcg cgtccgcctc ctcccaagct gagctctgct ccgcccacct
     5161 gagtccttcg ccagttagga ggaaacacag ccgcttaatg aactgctgca tcgggctggg
     5221 agagaaagct cgcgggtccc accgggcctc ctacccaagt ctcagcgcgc ttttcaccga
     5281 ggcctcaatt ctgggatttg gcagctttgc tgtgaaagcc caagtgggta accaacagct
     5341 tggaggaccc gagtggattc gattctctct cactcctcgg ccactcaact gctccttgtc
     5401 cctgactccg cggtggggat gaataactca actcatttcg ggccgctttt ctcagagggc
     5461 aaagatgggt cagggtggga tgttacatta gtgttgagac tctttggatc cgtttcgtgg
     5521 gtaccgagga cgcctgggta cgcgggacag gctgcacccg cctgctagag gcgccccatc
     5581 gaggcgccac gggtgaagct cccggcccca cctacggggc ggggctccgg ctcggtccga
     5641 ctattgcccg cggtggggga gggggatgga tcacgccacg cgccaaaggc gatcgcgact
     5701 ctccttctgc aggtagcctg gaaggctctc tctctttctc tacgccaccc ttttcgtggc
     5761 actgaaaagc cccgtcctct cctcccagtc ccgcctcctc cgagcgttcc ccctactgcc
     5821 tggaatggtg cggtcccagg tcgcgggtca cgcggcggag ggggcgtggc ctgcccccgg
     5881 cccagccggc tcttctttgc ctctgctgga gtccggggag tggcgttggc tgctagagcg
     5941 atgccgggcc ggagttgcgt cgccttagtc ctcctggctg ccgccgtcag ctgtgccgtc
     6001 gcgcagcacg cgccgccggt gagtgagctt gagccgaggc gcagagaggg gcgtgcaggt
     6061 gcgggcgcgg atggaggcgc aggtgtggcg gcgcgagcgg gtacaaggaa cacctcgtgc
     6121 tgggcagctt ctttacgggg gtctgtggtt tcgtgcacag gggtgtgggt gcagagcggg
     6181 ctggcgaacc ccgtcctcgg tagattcggt gctacctgca actagaactc ctttaaagga
     6241 aatcctagtc tctgcaggat acctgggtgt gattcgcaca ttcttagatt tgagtgagtg
     6301 tacttgaata accagttcca ggcccttgca ttttgaagtg tttaaataaa atgttccggt
     6361 ggacctgtgt gcattactca atcaaggaca gactgcctga tggtcaggtg ctttctcccg
     6421 aagaagttca ggagttcagc ccaggatact gcagggccgt gggaaacgct gagtggtccc
     6481 aagcttgggc ggtgcgagca gcccagagca ggccccaaag ggccccctgt ggccttttgc
     6541 acccaagtca tgggatcgcc tgtcccgtgg ctctttccca cgagcaagtc acagggctac
     6601 ggacttccta actgcaagag acagtgaggg acgagcgtga ctctttcatt ttacagaaga
     6661 ggaagtagac ctagagtgag aaaatattta gccagaggtt acactgttgt ttactgaaca
     6721 tgcgtaacgt ccgagcctct tgacgcccag tactctttca taattcattt ctttataaag
     6781 caatcagact gcgtttgtct ttgccaacag aatcggataa gtaggaacct ggcgcatctg
     6841 gcctgaggct agatggtgat ggtcttgaat agtttaggta ggttattgaa agtggaagca
     6901 agatgtgcat tgtcttcttt tatacctgta aggagaaatt ctttaaaatc atggtgggat
     6961 atgatttagc cattaaaatt gatataatgt tcagcagata aaagtagaat ccagaatagt
     7021 atatacagtt tttcctgtaa taggaaaata cacagaacat gtatgtggac acgattaaag
     7081 gccttaaaat aaaattgctc cattgtgggt agggaattaa tttgcttgac ggtagttggt
     7141 tttatgggaa ttgggagaga ctttgatact ttgatactgt cagggccctt cattgaaaga
     7201 ccaccaggaa cacaccataa gctgaacaaa ttgggtttag tgttctttga ggcaaaggag
     7261 accacacacc atgagcgacg gacggtaggt tatagaaaaa aacccattac agaatttgaa
     7321 cttcggttgc atgatttggg gtaagactga ggaaccgggc tttgctgtag atagaatgct
     7381 gttagaaggt ggggcaattc tgactgagta aagaaggaac agccattctg tttagcacga
     7441 gaaggggatg tttggtgttt tgtgcgttgc aggtgccctt gtttttgtct gttcttagag
     7501 aaaatcttca agtggcattg ctttgtcttg gtgtgtcatg tctcagaata atcttatccg
     7561 acgtaggtat ctgtgggatt gttgatgtcc aggaggaaaa cagagcttac ctggctgtga
     7621 gtgtcagatc ggcttgtaat aatattgaga gatagctgtg ggactcagag cagtttcagg
     7681 tgttggaggc tgttttttct tctttctcaa tagctttatt tattctagca aaagtatttt
     7741 gatagctatt ttcagaagaa gaattaacaa cctctcaatg gatataatag ttcttatcta
     7801 gaacagcgat tatcaaagtc tagtctggcc actggtgtca ctttgggaag ctgttttcac
     7861 aggttttcaa tgaaactgga aaaataagaa tgcaaaacta aaattattaa tttagaatgt
     7921 taatctttac tctgattgta tggacttcaa gttttcattg ttgcaaacgt gttcttaaaa
     7981 ataacggcag aggtagatgt tatgtgcatg gaatttgttt tgttttaaca tctccatttg
     8041 gcagaataaa aatttggacc ctcctgtgcc aaggcctcat taattttttt ttactggcct
     8101 ggaaaatcct gggatccatg cactgaagga cctttagaac cttacagaag tttagtgact
     8161 tcattctctg agaagaataa gcagtttttc aactggagtc attatatgat aaactatagc
     8221 ctcatggtaa caaaagatat ttcaaaagta ctttcaataa atatgaataa tgagaagcag
     8281 ctttaaattg gaaacaagtc atttgattta gaacatctgt aaggattttt tgtgtgtttg
     8341 tttttgaggc ttttcacaat attcctatgt gaaggtcctc ctgagttatt cttcattatt
     8401 gaatttttta ggagtctatt aagagatgat ggtgaagaca gtggcacaag aaatgtctgg
     8461 agagatagcg ccagatgaca tcatccaggg ttctgtagac tcttattaag gattcagaaa
     8521 tttatcctaa aaaatgggag gatctggaac cagccaatgg gaggccatta gatggtttta
     8581 gacaagataa cattttcact ttaaaaagat gagtctggat tggaggtcag caagggtaga
     8641 tatgaggaga ctagtccaga aaagaaaaca gggtgcgttg aaggatggtg gcgccagggg
     8701 tgagggagag aagtagatgt tctagaaaaa aatcaggagg gcgaatgagc tgaaggaatc
     8761 gttgggtgag gatgagggag tgaggtgtca gcgtgacctg cacattgctg aagtgcttcg
     8821 ctgggcgaat ggtggcatcc gttccaggaa acatggggag gggaaagctt gggggctaaa
     8881 gaatgaggat cgttttcatt tggggtgtat gttaaatttc aggtggcaga gaggcatcca
     8941 gcaggccact cggactggca ctcagaagag agacactgag agtcactggc ataatgatat
     9001 tatatttgaa gcccttggag cagatgaact tacctagaaa taggatagag aaagagaaga
     9061 aaagagaact aggcaaaggc taagtaactt gcacatgtat gtgtcaagaa gaggagaaat
     9121 tgccaaagtt aaaacaggac aggccgggcg cggtggctca tgcctgtaat cccagcactt
     9181 tgggaggcca aggtgggcag atcacgtgag gtcaggagtt tgagactagc ctggccaaca
     9241 tggagaaacc ctgtctctac taaaaataca aaaattagct gggcatagtg gctcacgcct
     9301 gtagtcccag ctactcagga ggctgaggcg ggagaattgc ttgaacctgg gagggagagg
     9361 ttgcagtgag ccaagatcct gccattgcac tccagcctgg acaatgagcg aaacttcgtc
     9421 acagaaaaca aaaacaaaaa aataggagag taagtggaac aggaagctca gggaagagac
     9481 tgggacaggt taactatgtt gaatattatt gagatgtcag tggtattatg atgttgggca
     9541 actggaggtc attggtcacc tcgactggag cagtgttggg ggcagaaaac agcttgcggt
     9601 aggctaagtg tgattggcag gaaaggaact agaggggaga gatggctgct ctgcgtaata
     9661 aatctgaccc acttcataag atgtgcgaag atgaaacgta atggcttagt aattaattgc
     9721 caaagtaaac ttgtaaactc atttttatgc atcagcttct catactagtt aacagcgtat
     9781 gtcaacattg ttgacattag ctattgaatc agctttagca atgattttca cgcagttgcc
     9841 agaaatctca tagaccccat ctggcctagg aatttattgc acttcatctg cttttcccta
     9901 cttctcccaa agagggaaca cacaggtgta atccattcac ttattcaaca aatactgctt
     9961 gcctactatg tgccagactc ctaaacgctg ggaatgcgtc agccaatgag atagatgagg
    10021 tccttcctct catggagggt ttattcacat tcctttgacc taaatatcag tagcttaata
    10081 ggatgccatc ccatcaaagc ccagaagaca agtgaaaaca ttttcaagct catgtgaatt
    10141 cttgtacacg taggaaacat gcctctttgt attcagtgtt tctgctgagt tgtacataag
    10201 aggacattat aggaaaaact tgtctgcaaa atagttgttg atgaattcaa gaattgaatg
    10261 aatgaaaaat tgtctggcta gagttgtttg gcttctggtg ggtatgaaaa ctgacatgag
    10321 gtatgtaatt ttagattatc cttcattgtc tctttctgag tatttcaata agacaagcac
    10381 acaagggctt tctggacttt taaaattcac tattagaagc atacattatt tcattgaggg
    10441 tctcctaatt ctttcgggct caaatatttt aaggagctgt acaagttatg ccatttttta
    10501 agggtatggc gctttcattg agaccttaat gttctcttta tatttttgtg ttttttttag
    10561 aatgttgtgt tcagtagctc tgtaattaat ttctcttaat gaatggggag gacattcaaa
    10621 gaggcttaag tttctatcaa ataaccagaa aaattagaga attttctgac ccaaacagtc
    10681 ttttaaaagc actttccaga gagttttttg tttttttttt ttttctgaga tggagtcttg
    10741 ctctgtctcc caggctggag tgcagtcaca ctatctcgtc tcactgcaac ttccacctcc
    10801 cggcttcagg caattctcct acctcagcct tccgagtacc taggattaca ggcacatgcc
    10861 acccagctaa tttttgcatt gttagtagta acggggattt cgccatgttg gccaggctgg
    10921 tcttgaagtc ctgacctcag gtgatccacc cacctcagcc tcccaaggtg ctggaattac
    10981 aggcatgagc caccatgcct ggcccagaga gtttcaaatg cattgaaata tcagattttt
    11041 accacttatc ttcactctta ggagaccact gaggggcagg gagaaaggta gggaagggca
    11101 gggagagaga gagaaagaga ggtactgtgg ggagagggtt agagagaatt gattctaagt
    11161 tggattttgt ttcctgtgat agggtgtaca tagtatacca tccagaccac ataatctctc
    11221 ttcttatcat ctgtttctaa tctttaccta tcatctattt aagtttttac ctgccttaat
    11281 agagttgtct gttattaaac tgtttataaa cttggggata gtaaggaact ttaaataaca
    11341 ttaagtaagt tcattataat tctgttttag ggctactcgt gggttttgaa gctgtgtctc
    11401 cctgtagaat tcttttttga gggggaggaa gtagctcttt tttccaccct acccctaaaa
    11461 ctaacctttt tgcataaacg acttaggcgt tcatgccatg tgagcccctg aaatactgta
    11521 gtctcatagc tgccaacttt cttattttct gtcacactta tcctatttcc ttgcagccag
    11581 gttctatgcc aatttcacgt ttgtttattg ctaccaagag tcgttatcaa cctcagactc
    11641 actccacatg tattgttgct agcttgctct ttagttctta cctctggggc aggtcacatt
    11701 ctctcctaat actagacaga gcattttcaa ctttgctcac agttgtctag taagaaatgt
    11761 gcctgtaatt tgatgtttat tttggctttg gaacccaggg cgtgcaaatg tcattattag
    11821 gaagggatag gagtcattac gtttcactta atttgccgag ttgattctag tgatcaccag
    11881 aagccctgaa ctacgcgcag attattctgt taggaattaa attgaggcat tggttttatt
    11941 atctctgtgg gaagctgttt gatagaacag ggaaagccat tgactctgat tctgtcacca
    12001 gctgtgtaac tttctacaag tcactaatgg agcagggtct taagtccaca acatgatcat
    12061 aaaattaagc acttgggtta agtacccatc acagtattcc caactcatag gaaaacaatg
    12121 gtcagataaa caagaaaatg taaagcggag tatctcctca cagcagaact tatttacaaa
    12181 ttttacaaag taaaattaag ttgcaacccc tataagtctc taagtagctc atttattagc
    12241 aaaataagga aagccattta ccaatggtgg attacctaaa ttgtattcga ttgtagtagc
    12301 agaagtattg tgtccaggga aaatgaaatt attttacatg tcattgagaa cccttgtcct
    12361 ggactttggg aagaacatca atatcaatta aagaacaaag catgtgattt ttgagtgatt
    12421 tttcttgact gtcaacatac cgataactga tcagttgttg atatttatta gatgatcatt
    12481 gccaagtttg aagtgactga agagttagcc tctgaatcat ctgtataaaa caactacagg
    12541 cgaggatgtt ttcgaagaag ctgagaaaat aatgattgag tataacctgg aatggaatct
    12601 gctaagatct ataaaaattg acagtagtaa aaatatttgt gagtagaaaa aggcggagtt
    12661 gagcaaattc acaaaacttg tgaacatgcg aggtgtttaa agctcatggt tatttattat
    12721 agtattcctt ttcagatatt ttgtggaaaa tattggaatc tcacatgtgt tattgaaccg
    12781 gcaatataaa ccatgagctt catttgctct tgtggatata accgtcatca tttctgtgaa
    12841 ttatcagaaa tagaggccgg atatcctgat gtctcttgtg acagagccat tagatagctt
    12901 gctagctgta aagttttgca gtctttgagt tcacagttga gactgaagtt tttctaaacg
    12961 agctgccccc agccactatt actgaacacg aatggctttg gaaattagct tttgctacag
    13021 acttgatatt gtttcttaat gaattcaacg caaaattacc agacaaagcc agacatatgt
    13081 gagaaactta cagtgtggta aggcaaattt gacagctaat gtttgaatca caggtaatgt
    13141 caacctactt tatatattcc ccatgttatc aaaagttaaa acaaggtgct agacctccat
    13201 tcttacacag ctgtccagca gatacatttt ctgtgctcaa gctacagttc caggagtttt
    13261 ctgagctcaa gctacagttc caggagtttt ctgagctcaa gctacagttc caagagtttt
    13321 ctgagctcaa gctacagttc caagagtttt cttacctact ctactttatc ttattttgga
    13381 tttgtacttt tttaaaacaa ttattttact ttcacagaac tggttctcca gaggaaagga
    13441 gataaagaca cttgatatgt tgaatgagta acaaaagaat cataaatctg tgtggacttt
    13501 ttttgataag tttaggagaa ggttccattt tgccactaag cttggacaac ttcccctaaa
    13561 agagtctgtt cattccttgt ctcaggcagt gacgtcagtg ttgggggccg tcctcacctc
    13621 aaggagcgca gagtctggta ttgacaagga acgcaaacag atgattataa agcagtgtca
    13681 taaacatgtt gatgagagtg tgcacaaatg ctgtgggagg aaaggagggt atgaatattt
    13741 tcatatggaa gatagatgaa gacttcacaa gaaagaaaat gcttgaactg aatcttggaa
    13801 gttagaacca gcagttcacc aggtggggaa aaggcattct agcaagaggg aatagcacag
    13861 acacaggcat ggaagggtga gagatgatag gaagtgcctg cgtatggcta taaatactaa
    13921 ggggagtgtc aggagatgag gctgggatgg taagttacca tggaaagatg atgaagggcc
    13981 ctgtgctgtg tgccctgaaa atctggtttg ggaggcaaat cccaggacag gttgcaacac
    14041 acatggctgg taagtgcaga taatacatcc tatcaggtca tttactttta gtgctaagtc
    14101 agcctctcta acataaatat tttccatcta ctttgttaca tttgttcgtt actcaatata
    14161 tttgaaatat tagagccaaa ttataacacc tagcactttt acaaattgaa ttgaaactga
    14221 aaatccactt aatggtttag gattttagaa gttttcttgg aaagaaaaga cttattttaa
    14281 gaggcattga aacgtataaa agagcaatat cagacttgat gttgtcttca cagattaact
    14341 acttttgaaa ttgcttattc cgttggcaag catttgttat tttctgaaac ttaattttct
    14401 ttgcttttca gtggacagag gactgcagaa aatcaaccta tcctccttca ggaccaacgt
    14461 gagtaaacat cagatgatca aaactccctt tgacctttgt gaagtttttt ctgtatgtaa
    14521 taattgctca taaacgaacg atagtgaata aaatcttaag tcatgtttcc cattccgaga
    14581 cagaggtttg tttctcagat ttgtttatta tgcatttggc tgagatcttg gacaaatatg
    14641 aaaatatctt ccgattcaaa tgcccgtcgc tagactatca aaatcatcgg aaagaaaagg
    14701 attttcagcc agacgcggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg
    14761 ggtaaatcat aaggtcagga gatcgagacc atgctggcta acagtgaaac cccgtctcta
    14821 ctaaaaatac aaaaaattag ccaggcgtgg tggcgggcgc ctgtagtccc agctactctg
    14881 gaggctgagg caggagaatg gcgtgaaccc gggaggcgga gcttgcagtg agccgagatc
    14941 gcaccactgc actccagtct gggcgacaga gtgagactct gtctcaaaaa aaaaaaggaa
    15001 aggattttca ttctccactc aattctcctg tctaccatga agggtttttc tcatctttga
    15061 caaatgtaag ggctgtattt gaaatgacct gtgattctct atggtgcctg gatataaacc
    15121 accaaattat attgtaacaa aaaagcatag gccctcatat gtgaaacgtt ctcaaaataa
    15181 accttggcac aacaaagctg tcgaggacaa aacaggattg gaacacctaa gaggaggacc
    15241 aatgtcatga ttcagtgtgt ttaacattaa tatttttagt ctagattttg gtctttccaa
    15301 atcctcagtg tttaaatggg cctgtgagaa agccataata acagctcaca gacccctcag
    15361 agtgtacaga acagagaaaa gaaggaacag gtataggggg tggtgatctt tttctcctac
    15421 actgcccttt cgctgaaagt agcctgctgt ttgtaggggg aaacagtaca actctatcta
    15481 gtgatatcaa gatgacattt tcagttcgtg caacattcca aattacttac gttgtactgt
    15541 tgttgtctaa acgatgtatt ttaaatagcc tctgtcccag atagcgtgaa actgtaataa
    15601 actaagttct tttgacttac tcgcctttat gtagaaagag gccagtattt ggcaggaagc
    15661 aatttagagg taaccagttt ggatgttgtt tggggccagt gttcattcca gctctttctt
    15721 caatggcctg ctgtctgaaa gtcttccttt ctgtcatcac tggcatcatt ctggccttca
    15781 gtgacatgtc tgccttactg attgattatg tctctctgtt ggtctcactg ccccaattca
    15841 ttgaacattt aatgaggtgc cttccatgtt tgaggccgtt tctactccct tttaggtgca
    15901 ctttacatgt gtctataaat tgaatgccct gcaaaccata aacctttcct gattaggcat
    15961 tttactgact cttattgcca tgtgcatgtg agtgtgtgtc tacctatgtg catacatacc
    16021 tacatgtata catacatatg tactccaaaa cacatacacg tgtatacatg gacataactt
    16081 gtatgtttct ttccttgcct tcattttttc gctagctttc tttttatctc actagcctgc
    16141 tttcctacac aaaaagcctc ggctttgctc ttatccttct cttctctcaa ctctatcaat
    16201 ggatcttgag atttaggaga taactgtggt atttatgtac ctttgaatga caaacagacg
    16261 ttctgttcct ttgagatcat ccttttcaat taagtgcgta gatttgggca gcatccatgg
    16321 gcagatatga gggaagaaaa agataacctg tttggccagc atgactagtc aaatcaatgc
    16381 tgaagataaa ggaactgata gccagatcac ccctgagtcc atctgagtcc cattcagcat
    16441 ttctttccca ctgctcacgg gatgcctagc acttgctctc ttatttgtat atgtgtgtgt
    16501 tgtgtcactt ggactagttt ccatgccacc taggtagcca tgtgggttca ggtgatgttg
    16561 ctgatattat gaatggcatg gacattgcaa acactaagtc tcaaaaatga tgaaatgata
    16621 tttcttgttt gcagtgaagt aggaaaataa attgtgatga ctactgttga ttgaatacca
    16681 atgctgctaa gtgttttttt tatttttgca tttttcatat agtgtcttcc ctgctgttat
    16741 aaggtggata ctcttttatt cttatgggga aatggaggcg cacaagttaa atactgaaat
    16801 gttttagaaa actgtttaac gagaggtaaa atgtgcaatt atggctaagc tttagtcatt
    16861 aaaataattt ggtttattag attaaccagt tctctcaaat tctaattagt gcaggtttga
    16921 tggtagagag gtttgtgggg tctcatcatc cccacttcat tgtaatccct tcattgtccg
    16981 ttgtgttgtg ttcatcccct ctcatcgcgt ctctgagatc catgaaccta cccaggactc
    17041 taggctgaaa aagaatcagg aatttatggc gggtatagag gcatgatttg ggattggttg
    17101 gatgttatga ggtgaggagc agctgattgg agttcatagg gatgagatgc atatctccaa
    17161 caggccactg agttatcttt gctactagac atagaaatct aaatgcacag ttgaagggag
    17221 aggggagact agtaatacct gcccataata tggggaacaa taattactta ctgaattgtg
    17281 ggacaaaatt ttacatgtga aattatggtc tgtcagaaat ggaattaatt tgttgtgatg
    17341 aaaagttttt ttctagaata taagtattgt agcatttcat gtagatatca gctcctaaga
    17401 aaatggggaa cttgaaaatg ctttgagaag aacaaaattc gttcactatg attttgttta
    17461 aatgtacatt tccaaaatcg aatatacttt tctgtctaaa tcacaacctg aatgtctgct
    17521 agttaacagt ttcataaaac ctcatacata taccagggcc ccaagttaca cagcattatt
    17581 tagagaacca agtaattatt tatgatagtg gaaatataaa tagaaccaca gttcatgact
    17641 taggtaataa cccatcccca gctatggaca taagtctaga taacatttct atttaggaga
    17701 ctggtatcat tgtggcacat accagagtca ccctgccagt ctcaggagca gatcagtgga
    17761 acagatgatg gttattttta ggcataggtt tatactgata aaccactaac tggcacaccc
    17821 ttaaaagcta tttcagttta gtaaccaggg ccagaaaata atgttcctat agcaacaaaa
    17881 atagttgtag aattcatcca ccagaaatat ggcccagctt cactgataag tgactggatg
    17941 ttgctatatc ctcagaaatt gctgcacgta agttaaagag taggaagttg gaggatatga
    18001 cagaatacag cttgggcttg gactttgtcc aggaaaatga gaagagaaga ggtatatagt
    18061 agggaagatt aggatggctg acagaatcat gaaggttctt gaagctgatc gtgggaagat
    18121 aatacatgtt gccatctggg gcttaaaagg tgatcttcct gaaggcaaca ctggagacat
    18181 tggtttggca atagtgttac actctctgag agagaattct gaaactggaa accaattgga
    18241 gaattgtcta gagcccagac taaatctttg cagatattta ggagaaaaaa aaaatggcag
    18301 gtatttcccg tcagtgataa tcaggttaga gctcttaagc catagttgat tttttcatag
    18361 aaaaccaatt cacatgaacc ttccctacta gatcattcta ttccaggatt tctgtgaccg
    18421 cttatgattg tgttctcaac ctagaagcac taggtagaga atgaactttc tttccaaatt
    18481 ttggtttggg taaccaaatt ctacactgct gttaagactt tgcctctcat atattcttat
    18541 agatgtatct aactgaccct cacaaaaaac cctttcatca tttcaagatg atacacctct
    18601 cattacaggt acagaggtgc agttccatgg tacaccataa atcttgactt accaccctac
    18661 aaaagatggc atgaattgat gcttgacaag gcaccagtgg tatgctatga tgcttaaatc
    18721 ttttatttct ttatttttat tttttatttt atttctttat ttttatttat tgattgattt
    18781 tttttttgtt ttgagacaga gtctcactct gtcacccagg ctggaatgca gtggcacgat
    18841 ctcagctcgc cgcaacctcc gcctcctggg ttctagcaat ttccctgcct cagcttcccg
    18901 agtagctgga attacaggca cctgccacca tgccggctaa tttttgtatt tttagtagag
    18961 acaagatttt gccatgttgt ccaagctgat ctcaaactcc tgacctcgag tgatcctccc
    19021 acctcagcct cccaaagtgc tgggattata ggcatgagcc gccatgcccg gccatatttc
    19081 ttattttatt tatttatttt ccccccaagg accgtggaga ttctatatta aatcttttat
    19141 ttctaacttt attaaatatt attgtatttt taaaagaaca cttcatgaaa ttacccacag
    19201 aatagtttaa aattgtgctt ttgatacctt tctgccctat acgttaagtg acagcagagg
    19261 aaaagaggtc attcctctgt agcctttgtt cttttttgta aactttacct ttgtttcttt
    19321 ccctttatgt catctccctt catgtaaata attaagaatc aaattcactt taaagataaa
    19381 attagactta ctgtattaat gtattaatcg aggccaggca cggtggctca tgcctgtaat
    19441 caatcccagt actttgggag gctgaggcag gcggatcacc tgagatcaga agttcaagac
    19501 cagcctggcc aacatggtga aaccctgtct ctattaaaaa tacaaaaatt aggccaggcg
    19561 cggtggctca tgcctgtaat cccagcactt tgggaggccg aggcgggtgg atcacgaggt
    19621 caggagttcg agaccagcct ggccaagatg gtgaaacccc gtctctacta aaaatacaaa
    19681 aattagccag gcatggtggt gcatgcctgt agtcccagct acttgggagg ctgaggcaag
    19741 agaatcgctt gaacccggga ggcagaggtt gcggtgagca gagatcgtgc cattgcactc
    19801 cggcctgggc gacaagagca aaactccgtc ttaaaaaaaa aaatacaaaa attagctggg
    19861 aatggtgatg cacacttgta atctcagcta cttgggaggc tgaggcagga gaatcgcttg
    19921 aacctgggag gcagagattg cagtgagccg agatggtgct actgcactcc agcctgggtg
    19981 acagagcgag atgctgtttt aaaaaatata tatataaatt gtcaaatagc actctctttt
    20041 agctacatat gggtaagcca aaaggtaatc ttgacagcat ttcattatgt cttttagtaa
    20101 gcattttatt tatttttcag ctaaaggtta tagtgaattc tctgaagaat atgataaata
    20161 cattcgtgcc aagtggaaaa attatgcagg tggtggatga aaaattggta agagatatta
    20221 tttctcacaa taaatgttaa gcacatagaa aatgcgctgt tatttattta aaggcataat
    20281 tcagcaacct cttcgcaggg acttgggcaa atctgcatga atctagctca ctgtcagaac
    20341 ttcagaggga cttaaatttg gggaattggt aatattaggg ttacagcata gcaaattatg
    20401 gtttcgtaaa aggggatggg actacattac gacattgggc aaataaccat atttcatctg
    20461 ggagtgtggt atttccttcc ctttatgtag tgagttcact attgaagact tggttttttt
    20521 tcttaagtgt ctcagggaca tccagagatt ttttttttgt agatatgagc aaatgacata
    20581 ctcagcctgg ccccttattc tgtagagttc ctcagtagct ctgaccctga aactcatttg
    20641 ggctgagtgt ttctgtgcaa tcaccaaacc atttcatttt catcctcatc atgcaggaag
    20701 actccatttc tcagccccgt ttttgttgac gcagaaccaa tgaaacacct agggcctggc
    20761 ccctagaact gttaaaggga tcctcattgc tcttgatggc agattttggg cattaatgac
    20821 atttggggtt gggcagcttt tttttttttt ttttttttga gacctcatct cactctgtag
    20881 cccaggctgg agtgcactgg catgatcata gctcacagct gccttgatct cccaggctca
    20941 agggatcctt ctgcctcagc ctcctgagta gctgggacta cagtcacgtg ccgccacacc
    21001 cagctacttt tctgaatttt tagtagagac ggaggcttgc tgtgtcaccc aggctggtct
    21061 cccaactcct gggctcaggc gatcttcccg cctcaacctc ccaaagtgtt ctcccaaagt
    21121 gttgggatcg taggtgtgaa ccgccatgcc cggcctgggt tggatatttc tttgtcgtgg
    21181 gcttgtctac attccaggat gcccggcctg gggtgggtgt ctcttttttg tggggctgtc
    21241 atgtgcattg caggatgttt agcagctcag gatgcccggc ctggggtggg tgtctctttt
    21301 ttgtggggct gtcatgtgca ttgcaggatg tttagcagtg tccctggccc ttacccactg
    21361 gatgctggta acaccccctc agttgtgaca accaaaaatg tccttagatg ttaccaaatc
    21421 tcccgtggtc gagaatcatt gccctagcgg ctgagtgctg tggccacatc ctccctatga
    21481 cacttgtacc tgccaagcac caaacccatt atccctcacg tgcatgctct cggagctttt
    21541 gtttcaggct atcctttatg ttcatactta ccggacttcc tcaaaacaaa aaaatgctgg
    21601 caggagcaaa agaggatgag gcccccacgt tccccgtatg ccttaatctc ccctctactc
    21661 tgaatgttat cagggagggc aacattgcag agagtttttg tgccacgcct tggaatcgga
    21721 caatactggg ttttaaggct ggatcagtca catactagcc ttgtgtccta gggaaagttt
    21781 cttaacctat gaaacctcag ttttctcatc agggagaata ataattacta atatatattt
    21841 catatggtgg ttgtaagggt taaatgacat actgtgtata aagcatagtg cttggatgta
    21901 ataagtgttt aataaatacc cattacgtca catttgtttg ttaaatggct ggaacattcc
    21961 acttggggaa tgctttgagt tcctagggag aaaaaaaata tgtttaggtg acattacatg
    22021 taattaccaa gttggttaaa aaagtgagat tcgtgaattt taagcagatt atctcagcaa
    22081 aaggccgtga acttaagttg tgatctggat gttagtagtt gccattgaga ataaatatat
    22141 gatgtccacc actgaatttg ctcaatgtct ctggtttgct aaaagaatgc agttacttca
    22201 tcttagctga agatcagcca ttaaccatga cacagggcta tggatagaat agtgcaggtt
    22261 tatctctgtg agtgtgggaa ggaaatggta agaacggtat atgccagtgg ctagagggtg
    22321 aattcgtgca gagagataag gagtgcttgt tatgatgttt ttgtggtgtg ggtcaggtta
    22381 ggtcatccaa gtggaattac tctcgttcct gccttctctg gagaatgatg gaaaaataag
    22441 gcaggaaaaa caatctgaga atctggtctc tgtatagggg cccaatattc agtattacat
    22501 agaatctttt tataactaca tgatgtaaaa atgctttaaa aaataattcc tatcacttat
    22561 tatgatagca gtatctagaa aaaattatat gtccaagaac tagatttcaa agcatgcttt
    22621 tattatattt gtttatatta tattatatat tttttattgt tattatgtta aatgctttta
    22681 ttaatatatt tgttttccag cctggcctac ttggcaactt tcctggccct tttgaagagg
    22741 aaatgaaggg tattgccgct gttactgata tacctttagg taaagttcac ttagaagctt
    22801 taaaaaaaaa agtaattaaa ttcttttaca agtttccatt gaggtgtgat atacatacag
    22861 cacaggtgct gtatgtctta gatatacagc acaggtgcac aggtcttaga tatacagctc
    22921 agtgaagctt cagaaatgca tgcatgcatg tagccatgac tcagatcaag atacggaaga
    22981 gcccagcact ccacgatgct ccatcatgcc cctttgcaga aaatactgcc tcctccagta
    23041 aacactattc tgatgtcact atagattagt tttgcctctt cgtgaacttt gtataaatag
    23101 aactgaacaa tatgaactgt cctgtgtgat ttcttgtatt tcattatggg tggtgtgcta
    23161 ttgtatcaac agggtatttg ggtggttttc agatttgtga tattaacaat aaaggaatta
    23221 taaatattgt agtacatttt gggggtgtct gggtactcat tttctggata tatacctagg
    23281 aagtgaactg ttgtgttata gagtaattgt gtgtttagcc ttatagattc tgccaaacag
    23341 ttttccaaag tgattccagc agttgacaat cagcagagta tgagagtttc agttttctcc
    23401 tcttgataat tctcctctcg atagtgtcag tctttttttt tccttttttt ttgttagtgt
    23461 caatctttat ttgagccttt ttgttgagtg tcgcagtatc gcattttagt ttcaatttgc
    23521 atttccttga tgattaatga gattgaacag tttattgact tttttttttt ttttttggtt
    23581 ttctttgttt cttttggaga agggcttgtg aaggtctttt gcccttttaa aaattagatt
    23641 gaaggaattt tttacatact ttgaatataa gccctttgtc agatatatgg attctgaata
    23701 tctgctccca gtctatgacc ttcattttta ttctcttact tttgtctttt gatgaacaga
    23761 aatttttaat tttagtgaag tctaatatct cagtcttctc ttttatgagt agtgcctttt
    23821 gtatccattt aaggaatctt ggcctacccc aaagtcatat atatatgctt atatattttc
    23881 ttctagatgt ttaatgttta ctttttacat ttaggcctat catctatttt gaattatttt
    23941 tgtatatgct atgacttatg ggtcaagctt caggtttttc tcatgtggta tatccagtta
    24001 gttaaacagc atcaattcaa aaggctatcc tttcctcagc aaattgcagt ggtgtctttg
    24061 atataaatat acaatacata tatatataca cacacacaca cacacacaca cacacaatgt
    24121 gtatctgtat atacaatcag gtgattgtat atatgttgtt ttgtttgggg aattaagttt
    24181 catttacata tttgtctttt tgtcttccct tatatcaata ctatttcacc tcagttacta
    24241 aagctttata gtaagtcttc aaattaggtg gtataattct tccaactttg tttttctcaa
    24301 tatttattta agttactgat ttctctgagc agtatctttt attttcaggg agaagacctc
    24361 acatgccatt cgttaaaatt attcttagat attgatggtt tgggaagcta tttttaaaat
    24421 ttcaatttaa gctttatggc atgtaacgaa aaatattttc cccacgaccc caaaagtttt
    24481 atctttaagc tagcaaagca gtagtgtcat tattttaaat agccaacagt accttcattt
    24541 tatgagatga ttgagaattt gtgaaaatca gtagtattta tcaacaaaag tggctagttt
    24601 tgtgtgctgc ttctttaaaa aactcattta aaagatagca tactggaaat atgtacttgc
    24661 tgcctttatg gaaagcaagt ctaattcctt tattatgtaa agaactctag caactcaata
    24721 ccaaatagaa ataccttatg gattaagaag aataacatga tgtataagtg gtgtaaattt
    24781 atataattat tataaattat tataaatgta taataaaata actagaattt caccaaatta
    24841 gaaatttaat ggaaataaaa tacacattgg atttgggtga aaaaaacatg ttgagcttaa
    24901 catgttaatg ttaaatggga cagaaataca atgtgctgcc tacttttgaa ttaaatgcta
    24961 aatagcagta ttatacattt tgggaaaata ttcaaaaaat aaaataccct agaatggagt
    25021 ttcttggcag ctctgtacta attttaatag ttcttgaatc tcctttttca ccttagaaat
    25081 tttagtcaca ctttaaaaat ctgggcaaaa tatatgtcca gcaaacagcc aagagccaga
    25141 tgtattaaat gatcatattt acgctcccaa aagaaaattc aaaatgaagc atgttgataa
    25201 acattttgga tgtgatgttg gagaacaatt gcaacctgcc cagatgttca gctcgcccga
    25261 aggctgcctc cttggtgact tgtttcatct tgagtctaga gagtccaggc tggggaagaa
    25321 aaccacctcc agccggccgt tccagcacag ccccactggc caaagcacac actcacacaa
    25381 tgaaaacact gaaacttttt cttaaaacaa atttttctcc cattgtcatg gttctgtata
    25441 ttaacacaaa attttctttt ctcataggag agattatttc attcaatatt ttttatgaat
    25501 tatttaccat ttgtacttca atagtagcag aagacaaaaa aggtaattgt gcgctgaggg
    25561 agggtgggca gcatgaagca ctacataaag aaaaatcttc taaatgaaat tagaacttct
    25621 gaaatttggg cttgctatgt aaattctgtg tatgttgcat acagcttttt atttcttggt
    25681 aaaattttgt gattgtactg aaaattttcc ttattttcag actactgtac tgcctattaa
    25741 agttgatttc agacatgcaa aaaacctgga agaaatgttg cagggctaga aacattcttc
    25801 tcttcctcat agtttacttc tacccatcta catgctttga tggaagtgct cgcaggaggt
    25861 gcttccttat cttcgtgtat gtcatgacat ctgtcctttt cttgaggccc agaacacaca
    25921 ttctcccatc ctttcccagc caggcaaccc aatggatacc agcctcactt tcccatattt
    25981 ttcctgactg gttcccagag tacaaagcac aggacaactt cgctaactca ccctgatctt
    26041 tgacctatac tctgggtata aatctgcctg taccttaccc ttgagatgtc ctgctctagg
    26101 ggatgatgcc tgaagggaaa catttgatga atcacagtaa ttgaggctcc gatttctgtg
    26161 tcctggtaga accatgtgat agtgaaccaa aacatgacca ttgattcctt ttcccatatt
    26221 ctgatcttac ctggaaaccc gtgctctcag attttgtggg gttatctggc agatagacgg
    26281 tgacaacagt cccatctggt gaaggcttag gatattagga tgtttcttac ttcttattgt
    26341 ttgaagaaac agttgtgaat aaaaattaat caaaattaga ggccaggcac agtggcttac
    26401 acctgtaatg ccagcacttt gcgaggccga ggcgggcgaa tcatctgagg ttgggagttt
    26461 gacaccagac tggccaacat ggtaaaaccc cttctctact aaaagaaaaa tacaaaaaaa
    26521 aaaaaaaagt agccaggtgc ggtcgcacat gtctgtaatc ccaactacgt ggaaggctga
    26581 ggcacaagaa ttgcttgaac ctgggaggca gaggtcgcag tgagctgaga tcgcaccact
    26641 gcactccagt ctggccaaca gaacgagact ctgtctcaaa aataaattaa ttaatcaaaa
    26701 ttaattgtcc agctttgatt tagaatctta actgctatta cacgtctctt ctgtctacct
    26761 tcaaataggt catctaatac atgggagaaa catggatttt ggagtatttc ttgggtaagt
    26821 aaagaacaaa gggtcaggca tggtggttca cgcctgtaat cccagctttt tgggaggctg
    26881 acacgggtgg atcacgaggt caggagttca agaccagcct ggccaagatg gtgaaacccc
    26941 gtctctacta aaaacataaa aattagccag gcatggtggt gggcatctgt aatcccggct
    27001 acttgggagc ctgaggcaga gacttttttg aacctgcgag gcggaggttg cagtgagccg
    27061 agatcgcgcc actgcactgc agcttgggat acagagccag actccatctc aaaaaaaaaa
    27121 aaaaaaaaaa gaacacagaa ctgttttggt ctgtaggaag agtaggttgt gttatattga
    27181 tgataagtaa gtcccaagtc acacccaaaa tgtgatcata agtgaagata aatggattgc
    27241 ttgagtgctg agacaagagg gacatgctct tctattttat gtgtccatct tgacctttct
    27301 gaaaaaataa gaatattgta attagcattc tatgtttgaa tctgaggctc actatttata
    27361 agctgtgtga tattgagaga gttacctgac ttctctgaac ctcaatttta tcatttggaa
    27421 aacagaataa atataccata ttgtaaaggt cttgttagga ttgatcgtgg tgactcggta
    27481 aataaagctc ctagtgtaat gcctggccct catcatcatg ttgatcatta ctatcactgt
    27541 gtttctgaaa tgtcactgaa acatgtcttt tataggtgga acataaataa tgatacctgg
    27601 gtcataactg agcaactaaa acctttaaca gtgaatttgg atttccaaag aaacaacaaa
    27661 actgtcttca aggcttcaag ctttgctggc tatgtgggca tgttaacagg attcaaacca
    27721 gtaaggagtc tgttgttaca taattataca ggtagccttc tgtcctgtta ccgttatgta
    27781 aaagttgaaa tctaagaata tgaggaccta aagggaatat gaagccccat ttcaccccct
    27841 tgtacttctt gtcacttcat aggtatgaga tctcgtggta gagaagagta gaaaggaaac
    27901 ggaggtttct gagcctcttc tgggataaag agcatgtggc tgggtgtcaa gggctgggag
    27961 tcacaatctg atttctagtc ctgggtcttc cgctcactta ggcaagtcag gcgttcattc
    28021 tctgcccttc agtttcctgt ccaaaaagcg ttgccagtga taccccacct acttatctca
    28081 catactagaa tcaaaaatgc tttgaacttt ttaaaaagcc ttttatggtt ttgatttatt
    28141 tttgccttcc ccattaccca agctaggcct ttatatccca ctctgaagta cagtgagcga
    28201 cagggcctta aagcgcatgg ttgatgtttc tgacttcgtt gctttgtctt tttctcaggg
    28261 actgttcagt cttacactga atgaacgttt cagtataaat ggtggttatc tgggtaagta
    28321 gagcattctc aagtgaaatg ggaatctcag agctttttta tgaggaaggc tggactgtgc
    28381 cttctggtta caaagtccaa cctcttccgg ttcccgactg gttacaaagt ctaacctctt
    28441 ctggttcctg actggttata tagtccagcc tcttccgggt cctgactggt tacatagtgt
    28501 cacctcttcc ggttcctgac attgtgttca tctcttccag gtattctaga atggattctg
    28561 ggaaagaaag atgtcatgtg gatagggttc ctcactagaa cagttctgga aaatagcaca
    28621 aggtaaagtg tttcgttgct ttactattaa atatttattt taaattactc atattaaaaa
    28681 ataaaaatat ttgtcaagct ccagcttaat cctttgagga actattgcag aatttcttag
    28741 gtgaacctct gacactcatg tggaattact catgttttct tcgtgcagac tgtgtgtttt
    28801 atagcaaata aatgaattac ttaaaaagca ctagggatac tgacattatg aaaggcacct
    28861 atgaatattt ttggtgtaca gaaaaaaaat gacccacaca caaaagaaca gtcatacagt
    28921 aaaatcttca tttaaatggt agtacagacc aggcacagtg gcttatgcct gtaatcctca
    28981 cgctttgggt ggctgagata gacagatgac ttgcacccag gggtttgaga ccagtctgag
    29041 caacatggcg aaaccccgtc tctataaaaa atacaaaaat tagccaggca tggtgacacg
    29101 tgcctgcctg tagtcccagc tactcaggag gctgaggtgg gaggatcacc tgagcccaag
    29161 gaggtcgaga ctgcagtgag ctgggatcag tccactgcac ttcaccctga gtgatagagt
    29221 gagactctgt cttaaaaaaa caaaataaat aaatacaaaa tgtactacat attaacctgt
    29281 aagttatatc ttgccttggt atagaaatct tacaatagca aaactgcctt tccttcattc
    29341 agccagcact gcgtccaaat aaatgggcat caatcctatt tttaatactt cccagggaat
    29401 aagatttaat gttagtagtg ttctttgata acccacttca atttttaata gtcctaattt
    29461 tcaagaaggt ttactttctg ttctctaagt cctacatact gtaatattat ttccctttgt
    29521 tctgttgttg agtgaaaggc atggacagta agggtggaag atgatctctt gaggccactt
    29581 tgtttctcct tcagattaga ggggcttcct aagattcccg cttcccatct cagtgttcac
    29641 catacagggt cagggattgc ttttcccaga ggcattgctc accatccttt tttagaaaac
    29701 acattgtggc tggccatggt ggctcatgcc tgtaatccca gtactttggg aggcgaaggc
    29761 aagagtatcg cttgtgccaa ggagttcgag accagcctgg gcaacagagt gagagcccat
    29821 ctctaaaaat agaaataaat aaataacaca ttccttagat acttgttttt ctttagtttc
    29881 tacagagcta aacatttccg ttctaagtca tctaaaaatg tttcccacca tcatcctcag
    29941 caaactaaca caggaacaga aaaccgaaca ctgcatgttc tcactcataa gtgagagctg
    30001 aacaaagaga acacgtgaac acagggaggg gaacatcacg caccagggcc tgtcaggggg
    30061 tggggtgaaa ggggagggag agcattagga caaataccta atgcatgtag ggcttgaaac
    30121 ttagatgatg ggttgatggg tgcagcaaac caccatggca cgtgtgtacc tatgtaacaa
    30181 acctgcacgt tcagcacatg tgtcccagaa cttaaagtaa aatttaaaaa taaatgaagt
    30241 tatttactaa aattaaaaaa aagtttcatt tttcttttta aatgtttcta tatagttatg
    30301 aagaagccaa gaatttattg accaagacca agatattggc cccagcctac tttatcctgg
    30361 gaggcaacca gtctggggaa ggttgtgtga ttacacgaga cagaaaggaa tcattggatg
    30421 tatatgagta agtaggtttg ttaaagcaaa agaagtagaa acaaaagcat acactgatat
    30481 actttgagtt ttaaggcatg tagcctaaga gggaatctct ccttttgtat ctagactcga
    30541 tgctaagcag ggtagatggt atgtggtaca aacaaattat gaccgttgga aacatccctt
    30601 cttccttgat gatcgcagaa cgcctgcaaa gatgtgtctg aaccgcacca gccaagaggt
    30661 acctttgcag ggtcatctat agaaagaaac tgttgccatt aaagattccc ttggttctgg
    30721 catttttctt tggccttcaa gtaatttata aacgtcctat ttttcatagt atctctagcc
    30781 actctccact gatttttttg tttcgttttc ttaacttaaa gagcaaaatt gtgctgtact
    30841 ttccttttct ggttctaatg ctggatacca ctctgaagtt gaataacaaa caggcaagaa
    30901 tttaaaaaag gggaaggaga gagaggaaag taatccatta aaactgttac ctgtgtttct
    30961 aacagtgact cccacagaaa ctccactgcg gggatggagg ggaggttgat taaagaatgt
    31021 cttggtttct ggtggcccat gtgtgtagat aaggctgttg gcttctgtat ttaacttact
    31081 gaacaaaact attttcttgt gttttagaat atctcatttg aaaccatgta tgatgtcctg
    31141 tcaacaaaac ctgtcctcaa caaggtattt taaatgttat atgtatattt gccttttagg
    31201 gaaagaattt ggccctatgt tttatctttc tctgttatct ttgatcagtt tgagcacaaa
    31261 aggtgtgttc agcttaggac tgatttttta ttaaaaaatg tttttgtgtg gctaaaactg
    31321 tattttggaa tacaagaaag aaattgatca ctgaggcttg ataggtcaga atattgttta
    31381 tagctttatt tacatagcat ttgaattaag gctagcattt tactcttatt ggtatctatt
    31441 aaaaatctca cactatataa ctaacaccta aatgtcaaca aaacaaagtc tgcagtccat
    31501 tttcagacag agctctgtgt cttggtgggt tcgggtttcc cttaaacttt actacatctg
    31561 tttatctttt ccctacactg tagttttaaa aaaatgcaaa aagtttccta tcatcccacc
    31621 actcgctaac aatcattccc tgaacgttct gaatatgccc ccctaatttt cccatttgtt
    31681 ccttcttttc ttggtccttc tccacagctc tccctaaagt aaacatgccg cctttaccct
    31741 gccaggacaa atccctccgg cctttagcat ccaggtcacc ctggctctca caggaagcct
    31801 gccttcagtt cacgggccct gccatacttg cgttttgcct ataccatctt tgagcaagtc
    31861 acaatctcgt gacttgtgtt tgggtgtgtg ccttgtgatc tgggtgcctg cagtttcccc
    31921 cactgtattg gaaatgcttt aaggataggg atagccaaag ctccacggtt tttactccat
    31981 aggacaccgg caggtctccc aggactgcca gctgtgcgtc aaggagggtt aaggcagtct
    32041 taaagcattg ggggtggagc aatgtgctgt caggaataag ctcctataag gagctggaga
    32101 ttctttcctg agcctgttta tattcattac ctgaaacagt gatcctgttg aagttgtttg
    32161 ctttagttat ttggtgagac tttagctaat tttatatgat tatactatat taatataaat
    32221 atatacatta tataacatgc tttgcatata ttaagttata ttatttaata ttaaataact
    32281 tctaaagcaa attctacaag tatagaaatg ctaatatata tcagaacatc tctgaattga
    32341 aaacgtcctt aaagtaaaaa taacttttct ttcagctgac cgtatacaca accttgatag
    32401 atgttaccaa aggtcaattc gaaacttacc tgcgggactg ccctgaccct tgtataggtt
    32461 ggtgagcaca cgtctggcct acagaatgcg gcctctgaga catgaagaca ccatctccat
    32521 gtgaccgaac actgcagctg tctgaccttc caaagactaa gactcgcggc aggttctctt
    32581 tgagtcaata gcttgtcttc gtccatctgt tgacaaatga cagatctttt ttttttcccc
    32641 ctatcagttg atttttctta tttacagata acttctttag gggaagtaaa acagtcatct
    32701 agaattcact gagttttgtt tcactttgac atttggggat ctggtgggca gtcgaaccat
    32761 ggtgaactcc acctccgtgg aataaatgga gattcagcgt gggtgttgaa tccagcacgt
    32821 ctgtgtgagt aacgggacag taaacactcc acattcttca gtttttcact tctacctaca
    32881 tatttgtatg tttttctgta taacagcctt ttccttctgg ttctaactgc tgttaaaatt
    32941 aatatatcat tatctttgct gttattgaca gcgatataat tttattacat atgattagag
    33001 ggatgagaca gacattcacc tgtatatttc ttttaatggg cacaaaatgg gcccttgcct
    33061 ctaaatagca ctttttgggg ttcaagaagt aatcagtatg caaagcaatc ttttatacaa
    33121 taattgaagt gttccctttt tcataattac tctacttccc agtaacccta aggaagttgc
    33181 taacttaaaa aactgcatcc cacgttctgt taatttagta aataaacaag tcaaagactt
    33241 gtggaaaata ggaagtgaac ccatatttta aattctcata agtagcattc atgtaataaa
    33301 caggttttta gtttgttctt cagattgata gggagtttta aagaaatttt agtagttact
    33361 aaaattatgt tactgtattt ttcagaaatc aaactgctta tgaaaagtac taatagaact
    33421 tgttaacctt tctaaccttc acgattaact gtgaaatgta cgtcatttgt gcaagaccgt
    33481 ttgtccactt cattttgtat aatcacagtt gtgttcctga cactcaataa acagtcactg
    33541 gaaagagtgc cagtcagcag tcatgcacgc tgattgggtg tgtacatctg tgttggtttg
    33601 gaggaggggg gttattatca agaaatacaa gctgaacatc gtatctgaat taaataacaa
    33661 gggttatgta agtgggttat taaatatgac taaacggtca caatcttact cttacatgac
    33721 tgataccacc tcttaaccag atactatcaa cccaatttgc aggtgtttaa aggcagtttt
    33781 tcccccagat aggtggtgct tccacaaaac tttagtgatt ccaagattac tttagtgaaa
    33841 cgaggaatta taagaggatt tacattaaaa taggatttaa ttaatgaaaa aaaaacttta
    33901 ctcagatttt ctacctctta cataaatgaa gtcaggtcaa cttgatgtat ttttttgtta
    33961 atgtaataac ctttgatatg cctgatagta aagaggtgag atgctaattg tttcagaccg
    34021 atttctccgg agtaaatcaa agtttacaag aaataacagg tattaagatt ttaggaagta
    34081 attgtttagt ggtaaagcag ttttaaaata ggatatacag gatgagcctg tttatataac
    34141 actttatata tgtacttatg cataactaga tacacatcta gaatatcaaa agatgactgg
    34201 gaggatatta accaaaatgc tgactgtagt tcctactgga taatggcaag tgctatttta
    34261 attttgagag gacaaaactt agtagccatt ggacattaat gagactctat ttttagaaat
    34321 actataaaaa aataaggtcc aggttggatc caaaccatgg gctccatcta atttccctgc
    34381 caagttttcg ggagtttgat tgtgaatgga aggctgaatc ctacctgtat tccttcacac
    34441 atcgagctcc tcagtcactc atcttaatta gagctcttgc ttatccattt atgtaccagg
    34501 ccttgtgatt gataaggtgc ttgacctaga ttacctcctc agcaaacccc ggtatcactt
    34561 gtaatcacac ttgccagcca tggaagtaac ttgctgaaag ttgcattaac agaagggctt
    34621 agagccaggg ttttagccag gtctgtccaa ctcctgcgct cttatgacac ccgaattctt
    34681 gactttacaa gtaggattga gaaacagctc tgtcctatga gacccacact tctgctgcca
    34741 tggaccaggc caccctgctg agcctggaca ccactgtgtc actgccttct acttgttctg
    34801 tgtcaattat taatgttccc atagggatca gaaacccttt ggtgttagga gctgacaggt
    34861 cacctgtttt tgactaccct gagtctgaat cgtgctcagc ttgtggggaa tgcgttaaga
    34921 gctcctcagt ctttctgtgg ctgtgaccca ggagtacgtg aaaaatatga atagttcaga
    34981 aatttataaa aagtcactat aaaacctcac acagtcatta ttgaagttag tctcacaaag
    35041 tgaagcatag tttttgttta ttggtgacaa tttacaaaat acttgccagc ttagcctcac
    35101 atatgacaga tgtgaccagc aggctccaga ccacaccgag ctgcatgctg gccccgtcta
    35161 caagcctggg gaagtgtggc tgggctcctc aaccttcaca acttggggag gttgctcagc
    35221 tcacatgaaa atcagtcctc tctttttccc tagggcactc tgtccctctt atgttgataa
    35281 agtgggtttc ccagccaggt ggcacagggg atgctagact ggtgtgcgtt gggcaattct
    35341 ctgtggcagt tctggacatc ttcaaggatg cttgtctagg cagaggacag atttgtttcc
    35401 tgactacggt aataaagatc atcatctacc tgtagggcaa aggttggatg agttgattgg
    35461 agaagcagcc catcttataa ctcgaggggt ttcctgagct tggggttcct cagctgtgat
    35521 acagatgata catcataaat tgggttgtca cacatcacct ccttggggga cttggggtgg
    35581 ggg
//

