Leiden Muscular Dystrophy pages^©

Antibodies against proteins of the Dystrophin Glycoprotein Complex

(last modified February 4, 2006)

Contents

• Introduction
• Dystrophin antibody links
• Antibody tables
  • DGC - proteins
    • alpha-/ß-dystroglycan
    • syntrophins
    • sarcoglycans
      • alpha-sarcoglycan
      • beta-sarcoglycan
      • gamma-sarcoglycan
      • delta-sarcoglycan
  • Associated proteins
  • caveolin-3
  • Dystrophin related proteins
    • Utrophin (UTRN)
    • DRP2
    • Dystrobrevin
  • others
    • FKRP
    • FCMD  (fukutin)
    • Titin (TTN)

Introduction

The antibodies listed below are a collection of those we have found in literature. Often, many details are lacking in these publications so we are not able to provide them. When you notice that we have missed antibodies, when you detect mistakes or when you can give additional information, please tell us immediately.

Dystrophin antibody links

• University Newcastle upon Tyne: Dr. Louise V.B. Anderson
• North East Wales Institute of Higher Education (NEWI): Prof. Glenn E. Morris

Antibody tables

alpha-/beta-Dystroglycan  (DAG1)

Legend:
Antibody: name of antibody. Epitope: epitope of the antibody (usually the sequence used to raise the antibody). Type: type of epitope used to raise the antibody fp = fusion protein, syn = synthetic peptide. M/P antibody is M = monoclonal, P = polyclonal. Raised in: animal in which the antibody was raised. IG-subtype: IG-subtype of the antibody. On coupe: signal on tissue sections: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). On Western: signal on Western blots: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). Cross react: observerd cross reactivity wit. Reference: publication providing details regarding the antibody. Supplier: supplier (if known).

alpha-Sarcoglycan  (SGCA)

Legend:
Antibody: name of antibody. Epitope: epitope of the antibody (usually the sequence used to raise the antibody). Type: type of epitope used to raise the antibody fp = fusion protein, syn = synthetic peptide. M/P antibody is M = monoclonal, P = polyclonal. Raised in: animal in which the antibody was raised. IG-subtype: IG-subtype of the antibody. On coupe: signal on tissue sections: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). On Western: signal on Western blots: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). Cross react: observerd cross reactivity wit. Reference: publication providing details regarding the antibody. Supplier: supplier (if known).

ß-Sarcoglycan  (SGCB)

Legend:
Antibody: name of antibody. Epitope: epitope of the antibody (usually the sequence used to raise the antibody). Type: type of epitope used to raise the antibody fp = fusion protein, syn = synthetic peptide. M/P antibody is M = monoclonal, P = polyclonal. Raised in: animal in which the antibody was raised. IG-subtype: IG-subtype of the antibody. On coupe: signal on tissue sections: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). On Western: signal on Western blots: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). Cross react: observerd cross reactivity wit. Reference: publication providing details regarding the antibody. Supplier: supplier (if known).

gamma-Sarcoglycan  (SGCG)

Legend:
Antibody: name of antibody. Epitope: epitope of the antibody (usually the sequence used to raise the antibody). Type: type of epitope used to raise the antibody fp = fusion protein, syn = synthetic peptide. M/P antibody is M = monoclonal, P = polyclonal. Raised in: animal in which the antibody was raised. IG-subtype: IG-subtype of the antibody. On coupe: signal on tissue sections: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). On Western: signal on Western blots: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). Cross react: observerd cross reactivity wit. Reference: publication providing details regarding the antibody. Supplier: supplier (if known).

delta-Sarcoglycan (SGCD)

Legend:
Antibody: name of antibody. Epitope: epitope of the antibody (usually the sequence used to raise the antibody). Type: type of epitope used to raise the antibody fp = fusion protein, syn = synthetic peptide. M/P antibody is M = monoclonal, P = polyclonal. Raised in: animal in which the antibody was raised. IG-subtype: IG-subtype of the antibody. On coupe: signal on tissue sections: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). On Western: signal on Western blots: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). Cross react: observerd cross reactivity wit. Reference: publication providing details regarding the antibody. Supplier: supplier (if known).

Dystrobrevin

Legend:
Antibody: name of antibody. Epitope: epitope of the antibody (usually the sequence used to raise the antibody). Type: type of epitope used to raise the antibody fp = fusion protein, syn = synthetic peptide. M/P antibody is M = monoclonal, P = polyclonal. Raised in: animal in which the antibody was raised. IG-subtype: IG-subtype of the antibody. On coupe: signal on tissue sections: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). On Western: signal on Western blots: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). Cross react: observerd cross reactivity wit. Reference: publication providing details regarding the antibody. Supplier: supplier (if known).

FKRP  (fukutin-related protein)

FCMD  (Fukuyama type congenital muscular dystrophy, fukutin)

Utrophin

Recently, Morris et al. published a paper entitled "An epitope structure for the C-terminal domain of dystrophin and utrophin", describing a detailed analysis of the MANCHO1-19 antibodies.

Legend:
Antibody: name of antibody. Epitope: epitope of the antibody (usually the sequence used to raise the antibody). Type: type of epitope used to raise the antibody fp = fusion protein, syn = synthetic peptide. M/P antibody is M = monoclonal, P = polyclonal. Raised in: animal in which the antibody was raised. IG-subtype: IG-subtype of the antibody. On coupe: signal on tissue sections: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). On Western: signal on Western blots: + = clear signal, - = no signal (ch=chicken, hu=human, mo=mouse, rat=rat, rb=rabbit). Cross react: observerd cross reactivity wit. Reference: publication providing details regarding the antibody. Supplier: supplier (if known).

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