(last modified March 2, 1999)
Submitted to GenBank
LOCUS Dp71 4623 bp mRNA PRI 20-JAN-1998
DEFINITION Human dystrophin cDNA isoform Dp71.
ACCESSION Dp71
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 255)
AUTHORS Rapaport,D., Lederfein,D., den Dunnen,J.T., Grootscholten,P.M., Van
Ommen,G.J., Fuchs,O., Nudel,U. and Yaffe,D.
TITLE Characterization and cell type distribution of a novel, major
transcript of the Duchenne muscular dystrophy gene
JOURNAL Differentiation 49 (3), 187-193 (1992)
MEDLINE 92316332
REFERENCE 2 (bases 1 to 98)
AUTHORS Hugnot,J.P., Gilgenkrantz,H., Vincent,N., Chafey,P., Morris,G.E.,
Monaco,A.P., Berwald-Netter,Y., Koulakoff,A., Kaplan,J.C., Kahn,A.
et,al.
TITLE Distal transcript of the dystrophin gene initiated from an
alternative first exon and encoding a 75-kDa protein widely
distributed in nonmuscle tissues
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7506-7510 (1992)
MEDLINE 92366490
REFERENCE 3 (bases 1 to 4623)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
FEATURES Location/Qualifiers
source 1..4623
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp21.2"
5'UTR <1..78
misc_feature 79..99
/note="Region: dystrophin Dp71/40 unique N-terminus"
CDS 79..1932
/codon_start=1
/product="dystrophin Dp71"
/translation="MREQLKGHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL
RRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVN
VPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGF
CDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMR
LEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSG
RVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLE
GDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSIS
PNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR
NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARM
QILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"
misc_feature <100..210
/note="Region: hinge region 4"
misc_feature <100..150
/note="Region: WW-domain"
misc_feature 112..1098
/note="dystroglycan binding site"
misc_feature 172..774
/note="Region: Cysteine-rich domain"
misc_feature 262..345
/note="Region: EF-hand 1"
misc_feature 406..492
/note="Region: EF-hand 2"
misc_feature 772..1929
/note="Region: Carboxy-terminal region"
misc_feature 793..936
/note="Region: ZZ-domain"
misc_feature 1204..1356
/note="alpha1-syntrophin binding site"
misc_feature 1357..1479
/note="beta1-syntrophin binding site"
misc_feature 1357..1479
/note="Region: beta1-syntrophin binding site"
misc_feature 1546..1653
/note="Region: (Leu)6-heptad repeat"
3'UTR 1933..4623
polyA_signal 4601..4606
polyA_site 4623
BASE COUNT 1399 a 948 c 920 g 1356 t
ORIGIN
1 actttcgggg agcccggcgg ctctgggaag ctcactcctc cactcgtacc cacactcgac
61 cgcggagccc ttgcagccat gagggaacag ctcaaaggcc acgagactca aacaacttgc
121 tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga
181 ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat
241 ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac
301 cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag
361 caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg
421 ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc
481 atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg
541 gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc
601 caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt
661 gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta
721 gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct
781 gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt
841 ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt
901 tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg
961 actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc
1021 aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag
1081 ggggacaaca tggaaactcc cgttactctg atcaacttct ggccagtaga ttctgcgcct
1141 gcctcgtccc ctcagctttc acacgatgat actcattcac gcattgaaca ttatgctagc
1201 aggctagcag aaatggaaaa cagcaatgga tcttatctaa atgatagcat ctctcctaat
1261 gagagcatag atgatgaaca tttgttaatc cagcattact gccaaagttt gaaccaggac
1321 tcccccctga gccagcctcg tagtcctgcc cagatcttga tttccttaga gagtgaggaa
1381 agaggggagc tagagagaat cctagcagat cttgaggaag aaaacaggaa tctgcaagca
1441 gaatatgacc gtctaaagca gcagcacgaa cataaaggcc tgtccccact gccgtcccct
1501 cctgaaatga tgcccacctc tccccagagt ccccgggatg ctgagctcat tgctgaggcc
1561 aagctactgc gtcaacacaa aggccgcctg gaagccagga tgcaaatcct ggaagaccac
1621 aataaacagc tggagtcaca gttacacagg ctaaggcagc tgctggagca accccaggca
1681 gaggccaaag tgaatggcac aacggtgtcc tctccttcta cctctctaca gaggtccgac
1741 agcagtcagc ctatgctgct ccgagtggtt ggcagtcaaa cttcggactc catgggtgag
1801 gaagatcttc tcagtcctcc ccaggacaca agcacagggt tagaggaggt gatggagcaa
1861 ctcaacaact ccttccctag ttcaagagga agaaataccc ctggaaagcc aatgagagag
1921 gacacaatgt aggaagtctt ttccacatgg cagatgattt gggcagagcg atggagtcct
1981 tagtatcagt catgacagat gaagaaggag cagaataaat gttttacaac tcctgattcc
2041 cgcatggttt ttataatatt catacaacaa agaggattag acagtaagag tttacaagaa
2101 ataaatctat atttttgtga agggtagtgg tattatactg tagatttcag tagtttctaa
2161 gtctgttatt gttttgttaa caatggcagg ttttacacgt ctatgcaatt gtacaaaaaa
2221 gttataagaa aactacatgt aaaatcttga tagctaaata acttgccatt tctttatatg
2281 gaacgcattt tgggttgttt aaaaatttat aacagttata aagaaagatt gtaaactaaa
2341 gtgtgcttta taaaaaaaag ttgtttataa aaacccctaa aaacaaaaca aacacacaca
2401 cacacacata cacacacaca cacaaaactt tgaggcagcg cattgttttg catccttttg
2461 gcgtgatatc catatgaaat tcatggcttt ttcttttttt gcatattaaa gataagactt
2521 cctctaccac cacaccaaat gactactaca cactgctcat ttgagaactg tcagctgagt
2581 ggggcaggct tgagttttca tttcatatat ctatatgtct ataagtatat aaatactata
2641 gttatataga taaagagata cgaatttcta tagactgact ttttccattt tttaaatgtt
2701 catgtcacat cctaatagaa agaaattact tctagtcagt catccaggct tacctgcttg
2761 gtctagaatg gatttttccc ggagccggaa gccaggagga aactacacca cactaaaaca
2821 ttgtctacag ctccagatgt ttctcatttt aaacaacttt ccactgacaa cgaaagtaaa
2881 gtaaagtatt ggattttttt aaagggaaca tgtgaatgaa tacacaggac ttattatatc
2941 agagtgagta atcggttggt tggttgattg attgattgat tgatacattc agcttcctgc
3001 tgctagcaat gccacgattt agatttaatg atgcttcagt ggaaatcaat cagaaggtat
3061 tctgaccttg tgaacatcag aaggtatttt ttaactccca agcagtagca ggacgatgat
3121 agggctggag ggctatggat tcccagccca tccctgtgaa ggagtaggcc actctttaag
3181 tgaaggattg gatgattgtt cataatacat aaagttctct gtaattacaa ctaaattatt
3241 atgccctctt ctcacagtca aaaggaactg ggtggtttgg tttttgttgc ttttttagat
3301 ttattgtccc atgtgggatg agtttttaaa tgccacaaga cataatttaa aataaataaa
3361 ctttgggaaa aggtgtaaga cagtagcccc atcacatttg tgatactgac aggtatcaac
3421 ccagaagccc atgaactgtg tttccatcct ttgcatttct ctgcgagtag ttccacacag
3481 gtttgtaagt aagtaagaaa gaaggcaaat tgattcaaat gttacaaaaa aacccttctt
3541 ggtggattag acaggttaaa tatataaaca aacaaacaaa aattgctcaa aaaagaggag
3601 aaaagctcaa gaggaaaagc taaggactgg taggaaaaag ctttactctt tcatgccatt
3661 ttatttcttt ttgattttta aatcattcat tcaatagata ccaccgtgtg acctataatt
3721 ttgcaaatct gttacctctg acatcaagtg taattagctt ttggagagtg ggctgacatc
3781 aagtgtaatt agcttttgga gagtgggttt tgtccattat taataattaa ttaattaaca
3841 tcaaacacgg cttctcatgc tatttctacc tcactttggt tttggggtgt tcctgataat
3901 tgtgcacacc tgagttcaca gcttcaccac ttgtccattg cgttattttc tttttccttt
3961 ataattcttt ctttttcctt cataattttc aaaagaaaac ccaaagctct aaggtaacaa
4021 attaccaaat tacatgaaga tttggttttt gtcttgcatt tttttccttt atgtgacgct
4081 ggaccttttc tttacccaag gatttttaaa actcagattt aaaacaaggg gttactttac
4141 atcctactaa gaagtttaag taagtaagtt tcattctaaa atcagaggta aatagagtgc
4201 ataaataatt ttgttttaat ctttttgttt ttcttttaga cacattagct ctggagtgag
4261 tctgtcataa tatttgaaca aaaattgaga gctttattgc tgcattttaa gcataattaa
4321 tttggacatt atttcgtgtt gtgttcttta taaccaccga gtattaaact gtaaatcata
4381 atgtaactga agcataaaca tcacatggca tgttttgtca ttgttttcag gtactgagtt
4441 cttacttgag tatcataata tattgtgttt taacaccaac actgtaacat ttacgaatta
4501 tttttttaaa cttcagtttt actgcatttt cacaacatat cagacttcac caaatatatg
4561 ccttactatt gtattatagt actgctttac tgtgtatctc aataaagcac gcagttatgt
4621 tac
LOCUS Dp71b 4591 bp mRNA PRI 20-JAN-1998
DEFINITION Human dystrophin cDNA isoform Dp71b.
ACCESSION Dp71b
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 255)
AUTHORS Rapaport,D., Lederfein,D., den Dunnen,J.T., Grootscholten,P.M., Van
Ommen,G.J., Fuchs,O., Nudel,U. and Yaffe,D.
TITLE Characterization and cell type distribution of a novel, major
transcript of the Duchenne muscular dystrophy gene
JOURNAL Differentiation 49 (3), 187-193 (1992)
MEDLINE 92316332
REFERENCE 2 (bases 1 to 98)
AUTHORS Hugnot,J.P., Gilgenkrantz,H., Vincent,N., Chafey,P., Morris,G.E.,
Monaco,A.P., Berwald-Netter,Y., Koulakoff,A., Kaplan,J.C., Kahn,A.
et,al.
TITLE Distal transcript of the dystrophin gene initiated from an
alternative first exon and encoding a 75-kDa protein widely
distributed in nonmuscle tissues
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7506-7510 (1992)
MEDLINE 92366490
REFERENCE 3 (bases 1 to 4591)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
FEATURES Location/Qualifiers
source 1..4591
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp21.2"
5'UTR <1..78
misc_feature 79..99
/note="Region: dystrophin Dp71/40 unique N-terminus"
CDS 79..1986
/note="alternatively spliced transcript; misses dystrophin
exon 78."
/codon_start=1
/product="dystrophin Dp71b"
/translation="MREQLKGHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL
RRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVN
VPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGF
CDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMR
LEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSG
RVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLE
GDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSIS
PNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR
NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARM
QILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAMESL
VSVMTDEEGAE"
misc_feature <100..210
/note="Region: hinge region 4"
misc_feature <100..150
/note="Region: WW-domain"
misc_feature 112..1098
/note="dystroglycan binding site"
misc_feature 172..774
/note="Region: Cysteine-rich domain"
misc_feature 262..345
/note="Region: EF-hand 1"
misc_feature 406..492
/note="Region: EF-hand 2"
misc_feature 772..1929
/note="Region: Carboxy-terminal region"
misc_feature 793..936
/note="Region: ZZ-domain"
misc_feature 1204..1356
/note="alpha1-syntrophin binding site"
misc_feature 1357..1479
/note="beta1-syntrophin binding site"
misc_feature 1357..1479
/note="Region: beta1-syntrophin binding site"
misc_feature 1546..1653
/note="Region: (Leu)6-heptad repeat"
3'UTR 1987..4591
polyA_signal 4569..4574
polyA_site 4591
BASE COUNT 1385 a 942 c 911 g 1353 t
ORIGIN
1 actttcgggg agcccggcgg ctctgggaag ctcactcctc cactcgtacc cacactcgac
61 cgcggagccc ttgcagccat gagggaacag ctcaaaggcc acgagactca aacaacttgc
121 tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga
181 ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat
241 ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac
301 cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag
361 caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg
421 ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc
481 atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg
541 gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc
601 caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt
661 gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta
721 gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct
781 gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt
841 ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt
901 tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg
961 actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc
1021 aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag
1081 ggggacaaca tggaaactcc cgttactctg atcaacttct ggccagtaga ttctgcgcct
1141 gcctcgtccc ctcagctttc acacgatgat actcattcac gcattgaaca ttatgctagc
1201 aggctagcag aaatggaaaa cagcaatgga tcttatctaa atgatagcat ctctcctaat
1261 gagagcatag atgatgaaca tttgttaatc cagcattact gccaaagttt gaaccaggac
1321 tcccccctga gccagcctcg tagtcctgcc cagatcttga tttccttaga gagtgaggaa
1381 agaggggagc tagagagaat cctagcagat cttgaggaag aaaacaggaa tctgcaagca
1441 gaatatgacc gtctaaagca gcagcacgaa cataaaggcc tgtccccact gccgtcccct
1501 cctgaaatga tgcccacctc tccccagagt ccccgggatg ctgagctcat tgctgaggcc
1561 aagctactgc gtcaacacaa aggccgcctg gaagccagga tgcaaatcct ggaagaccac
1621 aataaacagc tggagtcaca gttacacagg ctaaggcagc tgctggagca accccaggca
1681 gaggccaaag tgaatggcac aacggtgtcc tctccttcta cctctctaca gaggtccgac
1741 agcagtcagc ctatgctgct ccgagtggtt ggcagtcaaa cttcggactc catgggtgag
1801 gaagatcttc tcagtcctcc ccaggacaca agcacagggt tagaggaggt gatggagcaa
1861 ctcaacaact ccttccctag ttcaagagga cacaatgtag gaagtctttt ccacatggca
1921 gatgatttgg gcagagcgat ggagtcctta gtatcagtca tgacagatga agaaggagca
1981 gaataaatgt tttacaactc ctgattcccg catggttttt ataatattca tacaacaaag
2041 aggattagac agtaagagtt tacaagaaat aaatctatat ttttgtgaag ggtagtggta
2101 ttatactgta gatttcagta gtttctaagt ctgttattgt tttgttaaca atggcaggtt
2161 ttacacgtct atgcaattgt acaaaaaagt tataagaaaa ctacatgtaa aatcttgata
2221 gctaaataac ttgccatttc tttatatgga acgcattttg ggttgtttaa aaatttataa
2281 cagttataaa gaaagattgt aaactaaagt gtgctttata aaaaaaagtt gtttataaaa
2341 acccctaaaa acaaaacaaa cacacacaca cacacataca cacacacaca caaaactttg
2401 aggcagcgca ttgttttgca tccttttggc gtgatatcca tatgaaattc atggcttttt
2461 ctttttttgc atattaaaga taagacttcc tctaccacca caccaaatga ctactacaca
2521 ctgctcattt gagaactgtc agctgagtgg ggcaggcttg agttttcatt tcatatatct
2581 atatgtctat aagtatataa atactatagt tatatagata aagagatacg aatttctata
2641 gactgacttt ttccattttt taaatgttca tgtcacatcc taatagaaag aaattacttc
2701 tagtcagtca tccaggctta cctgcttggt ctagaatgga tttttcccgg agccggaagc
2761 caggaggaaa ctacaccaca ctaaaacatt gtctacagct ccagatgttt ctcattttaa
2821 acaactttcc actgacaacg aaagtaaagt aaagtattgg atttttttaa agggaacatg
2881 tgaatgaata cacaggactt attatatcag agtgagtaat cggttggttg gttgattgat
2941 tgattgattg atacattcag cttcctgctg ctagcaatgc cacgatttag atttaatgat
3001 gcttcagtgg aaatcaatca gaaggtattc tgaccttgtg aacatcagaa ggtatttttt
3061 aactcccaag cagtagcagg acgatgatag ggctggaggg ctatggattc ccagcccatc
3121 cctgtgaagg agtaggccac tctttaagtg aaggattgga tgattgttca taatacataa
3181 agttctctgt aattacaact aaattattat gccctcttct cacagtcaaa aggaactggg
3241 tggtttggtt tttgttgctt ttttagattt attgtcccat gtgggatgag tttttaaatg
3301 ccacaagaca taatttaaaa taaataaact ttgggaaaag gtgtaagaca gtagccccat
3361 cacatttgtg atactgacag gtatcaaccc agaagcccat gaactgtgtt tccatccttt
3421 gcatttctct gcgagtagtt ccacacaggt ttgtaagtaa gtaagaaaga aggcaaattg
3481 attcaaatgt tacaaaaaaa cccttcttgg tggattagac aggttaaata tataaacaaa
3541 caaacaaaaa ttgctcaaaa aagaggagaa aagctcaaga ggaaaagcta aggactggta
3601 ggaaaaagct ttactctttc atgccatttt atttcttttt gatttttaaa tcattcattc
3661 aatagatacc accgtgtgac ctataatttt gcaaatctgt tacctctgac atcaagtgta
3721 attagctttt ggagagtggg ctgacatcaa gtgtaattag cttttggaga gtgggttttg
3781 tccattatta ataattaatt aattaacatc aaacacggct tctcatgcta tttctacctc
3841 actttggttt tggggtgttc ctgataattg tgcacacctg agttcacagc ttcaccactt
3901 gtccattgcg ttattttctt tttcctttat aattctttct ttttccttca taattttcaa
3961 aagaaaaccc aaagctctaa ggtaacaaat taccaaatta catgaagatt tggtttttgt
4021 cttgcatttt tttcctttat gtgacgctgg accttttctt tacccaagga tttttaaaac
4081 tcagatttaa aacaaggggt tactttacat cctactaaga agtttaagta agtaagtttc
4141 attctaaaat cagaggtaaa tagagtgcat aaataatttt gttttaatct ttttgttttt
4201 cttttagaca cattagctct ggagtgagtc tgtcataata tttgaacaaa aattgagagc
4261 tttattgctg cattttaagc ataattaatt tggacattat ttcgtgttgt gttctttata
4321 accaccgagt attaaactgt aaatcataat gtaactgaag cataaacatc acatggcatg
4381 ttttgtcatt gttttcaggt actgagttct tacttgagta tcataatata ttgtgtttta
4441 acaccaacac tgtaacattt acgaattatt tttttaaact tcagttttac tgcattttca
4501 caacatatca gacttcacca aatatatgcc ttactattgt attatagtac tgctttactg
4561 tgtatctcaa taaagcacgc agttatgtta c
LOCUS Dp71a 4584 bp mRNA PRI 20-JAN-1998
DEFINITION Human dystrophin cDNA isoform Dp71a.
ACCESSION Dp71a
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 255)
AUTHORS Rapaport,D., Lederfein,D., den Dunnen,J.T., Grootscholten,P.M., Van
Ommen,G.J., Fuchs,O., Nudel,U. and Yaffe,D.
TITLE Characterization and cell type distribution of a novel, major
transcript of the Duchenne muscular dystrophy gene
JOURNAL Differentiation 49 (3), 187-193 (1992)
MEDLINE 92316332
REFERENCE 2 (bases 1 to 98)
AUTHORS Hugnot,J.P., Gilgenkrantz,H., Vincent,N., Chafey,P., Morris,G.E.,
Monaco,A.P., Berwald-Netter,Y., Koulakoff,A., Kaplan,J.C., Kahn,A.
et,al.
TITLE Distal transcript of the dystrophin gene initiated from an
alternative first exon and encoding a 75-kDa protein widely
distributed in nonmuscle tissues
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7506-7510 (1992)
MEDLINE 92366490
REFERENCE 3 (bases 1 to 4584)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
FEATURES Location/Qualifiers
source 1..4584
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp21.2"
/cell_type="amniotic fluid"
5'UTR <1..78
misc_feature 79..99
/note="Region: dystrophin Dp71/40 unique N-terminus"
CDS 79..1893
/note="alternatively spliced transcript; misses dystrophin
exon 71."
/codon_start=1
/product="dystrophin Dp71a"
/translation="MREQLKGHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL
RRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVN
VPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGF
CDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMR
LEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSG
RVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLE
GDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQ
HYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQH
EHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQ
LHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS
PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"
misc_feature <100..210
/note="Region: hinge region 4"
misc_feature <100..150
/note="Region: WW-domain"
misc_feature 112..1098
/note="dystroglycan binding site"
misc_feature 172..774
/note="Region: Cysteine-rich domain"
misc_feature 262..345
/note="Region: EF-hand 1"
misc_feature 406..492
/note="Region: EF-hand 2"
misc_feature 772..1890
/note="Region: Carboxy-terminal region"
misc_feature 793..936
/note="Region: ZZ-domain"
misc_feature 1165..1317
/note="alpha1-syntrophin binding site"
misc_feature 1318..1440
/note="beta1-syntrophin binding site"
misc_feature 1318..1440
/note="Region: beta1-syntrophin binding site"
misc_feature 1507..1614
/note="Region: (Leu)6-heptad repeat"
3'UTR 1894..4584
polyA_signal 4562..4567
polyA_site 4584
BASE COUNT 1392 a 936 c 913 g 1343 t
ORIGIN
1 actttcgggg agcccggcgg ctctgggaag ctcactcctc cactcgtacc cacactcgac
61 cgcggagccc ttgcagccat gagggaacag ctcaaaggcc acgagactca aacaacttgc
121 tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga
181 ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat
241 ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac
301 cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag
361 caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg
421 ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc
481 atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg
541 gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc
601 caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt
661 gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta
721 gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct
781 gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt
841 ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt
901 tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg
961 actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc
1021 aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag
1081 ggggacaaca tggaaacgcc tgcctcgtcc cctcagcttt cacacgatga tactcattca
1141 cgcattgaac attatgctag caggctagca gaaatggaaa acagcaatgg atcttatcta
1201 aatgatagca tctctcctaa tgagagcata gatgatgaac atttgttaat ccagcattac
1261 tgccaaagtt tgaaccagga ctcccccctg agccagcctc gtagtcctgc ccagatcttg
1321 atttccttag agagtgagga aagaggggag ctagagagaa tcctagcaga tcttgaggaa
1381 gaaaacagga atctgcaagc agaatatgac cgtctaaagc agcagcacga acataaaggc
1441 ctgtccccac tgccgtcccc tcctgaaatg atgcccacct ctccccagag tccccgggat
1501 gctgagctca ttgctgaggc caagctactg cgtcaacaca aaggccgcct ggaagccagg
1561 atgcaaatcc tggaagacca caataaacag ctggagtcac agttacacag gctaaggcag
1621 ctgctggagc aaccccaggc agaggccaaa gtgaatggca caacggtgtc ctctccttct
1681 acctctctac agaggtccga cagcagtcag cctatgctgc tccgagtggt tggcagtcaa
1741 acttcggact ccatgggtga ggaagatctt ctcagtcctc cccaggacac aagcacaggg
1801 ttagaggagg tgatggagca actcaacaac tccttcccta gttcaagagg aagaaatacc
1861 cctggaaagc caatgagaga ggacacaatg taggaagtct tttccacatg gcagatgatt
1921 tgggcagagc gatggagtcc ttagtatcag tcatgacaga tgaagaagga gcagaataaa
1981 tgttttacaa ctcctgattc ccgcatggtt tttataatat tcatacaaca aagaggatta
2041 gacagtaaga gtttacaaga aataaatcta tatttttgtg aagggtagtg gtattatact
2101 gtagatttca gtagtttcta agtctgttat tgttttgtta acaatggcag gttttacacg
2161 tctatgcaat tgtacaaaaa agttataaga aaactacatg taaaatcttg atagctaaat
2221 aacttgccat ttctttatat ggaacgcatt ttgggttgtt taaaaattta taacagttat
2281 aaagaaagat tgtaaactaa agtgtgcttt ataaaaaaaa gttgtttata aaaaccccta
2341 aaaacaaaac aaacacacac acacacacat acacacacac acacaaaact ttgaggcagc
2401 gcattgtttt gcatcctttt ggcgtgatat ccatatgaaa ttcatggctt tttctttttt
2461 tgcatattaa agataagact tcctctacca ccacaccaaa tgactactac acactgctca
2521 tttgagaact gtcagctgag tggggcaggc ttgagttttc atttcatata tctatatgtc
2581 tataagtata taaatactat agttatatag ataaagagat acgaatttct atagactgac
2641 tttttccatt ttttaaatgt tcatgtcaca tcctaataga aagaaattac ttctagtcag
2701 tcatccaggc ttacctgctt ggtctagaat ggatttttcc cggagccgga agccaggagg
2761 aaactacacc acactaaaac attgtctaca gctccagatg tttctcattt taaacaactt
2821 tccactgaca acgaaagtaa agtaaagtat tggatttttt taaagggaac atgtgaatga
2881 atacacagga cttattatat cagagtgagt aatcggttgg ttggttgatt gattgattga
2941 ttgatacatt cagcttcctg ctgctagcaa tgccacgatt tagatttaat gatgcttcag
3001 tggaaatcaa tcagaaggta ttctgacctt gtgaacatca gaaggtattt tttaactccc
3061 aagcagtagc aggacgatga tagggctgga gggctatgga ttcccagccc atccctgtga
3121 aggagtaggc cactctttaa gtgaaggatt ggatgattgt tcataataca taaagttctc
3181 tgtaattaca actaaattat tatgccctct tctcacagtc aaaaggaact gggtggtttg
3241 gtttttgttg cttttttaga tttattgtcc catgtgggat gagtttttaa atgccacaag
3301 acataattta aaataaataa actttgggaa aaggtgtaag acagtagccc catcacattt
3361 gtgatactga caggtatcaa cccagaagcc catgaactgt gtttccatcc tttgcatttc
3421 tctgcgagta gttccacaca ggtttgtaag taagtaagaa agaaggcaaa ttgattcaaa
3481 tgttacaaaa aaacccttct tggtggatta gacaggttaa atatataaac aaacaaacaa
3541 aaattgctca aaaaagagga gaaaagctca agaggaaaag ctaaggactg gtaggaaaaa
3601 gctttactct ttcatgccat tttatttctt tttgattttt aaatcattca ttcaatagat
3661 accaccgtgt gacctataat tttgcaaatc tgttacctct gacatcaagt gtaattagct
3721 tttggagagt gggctgacat caagtgtaat tagcttttgg agagtgggtt ttgtccatta
3781 ttaataatta attaattaac atcaaacacg gcttctcatg ctatttctac ctcactttgg
3841 ttttggggtg ttcctgataa ttgtgcacac ctgagttcac agcttcacca cttgtccatt
3901 gcgttatttt ctttttcctt tataattctt tctttttcct tcataatttt caaaagaaaa
3961 cccaaagctc taaggtaaca aattaccaaa ttacatgaag atttggtttt tgtcttgcat
4021 ttttttcctt tatgtgacgc tggacctttt ctttacccaa ggatttttaa aactcagatt
4081 taaaacaagg ggttacttta catcctacta agaagtttaa gtaagtaagt ttcattctaa
4141 aatcagaggt aaatagagtg cataaataat tttgttttaa tctttttgtt tttcttttag
4201 acacattagc tctggagtga gtctgtcata atatttgaac aaaaattgag agctttattg
4261 ctgcatttta agcataatta atttggacat tatttcgtgt tgtgttcttt ataaccaccg
4321 agtattaaac tgtaaatcat aatgtaactg aagcataaac atcacatggc atgttttgtc
4381 attgttttca ggtactgagt tcttacttga gtatcataat atattgtgtt ttaacaccaa
4441 cactgtaaca tttacgaatt atttttttaa acttcagttt tactgcattt tcacaacata
4501 tcagacttca ccaaatatat gccttactat tgtattatag tactgcttta ctgtgtatct
4561 caataaagca cgcagttatg ttac
LOCUS Dp71ab 4552 bp mRNA PRI 20-JAN-1998
DEFINITION Human dystrophin cDNA isoform Dp71ab.
ACCESSION Dp71ab
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 255)
AUTHORS Rapaport,D., Lederfein,D., den Dunnen,J.T., Grootscholten,P.M., Van
Ommen,G.J., Fuchs,O., Nudel,U. and Yaffe,D.
TITLE Characterization and cell type distribution of a novel, major
transcript of the Duchenne muscular dystrophy gene
JOURNAL Differentiation 49 (3), 187-193 (1992)
MEDLINE 92316332
REFERENCE 2 (bases 27 to 2136)
AUTHORS Lederfein,D., Levy,Z., Augier,N., Mornet,D., Morris,G., Fuchs,O.,
Yaffe,D. and Nudel,U.
TITLE A 71-kilodalton protein is a major product of the duchenne muscular
dystrophy gene in brian and other nonmuscle tissues
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89, 5346-5350 (1992)
MEDLINE 92302239
REFERENCE 3 (bases 1 to 98)
AUTHORS Hugnot,J.P., Gilgenkrantz,H., Vincent,N., Chafey,P., Morris,G.E.,
Monaco,A.P., Berwald-Netter,Y., Koulakoff,A., Kaplan,J.C., Kahn,A.
et,al.
TITLE Distal transcript of the dystrophin gene initiated from an
alternative first exon and encoding a 75-kDa protein widely
distributed in nonmuscle tissues
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7506-7510 (1992)
MEDLINE 92366490
REFERENCE 4 (bases 1 to 4552)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
FEATURES Location/Qualifiers
source 1..4552
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp21.2"
5'UTR <1..78
misc_feature 79..99
/note="Region: dystrophin Dp71/40 unique N-terminus"
CDS 79..1947
/note="alternatively spliced transcript; misses dystrophin
exons 71 and 78."
/codon_start=1
/product="dystrophin Dp71ab"
/translation="MREQLKGHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL
RRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVN
VPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGF
CDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMR
LEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSG
RVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLE
GDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQ
HYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQH
EHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQ
LHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS
PPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE"
misc_feature <100..210
/note="Region: hinge region 4"
misc_feature <100..150
/note="Region: WW-domain"
misc_feature 112..1098
/note="dystroglycan binding site"
misc_feature 172..774
/note="Region: Cysteine-rich domain"
misc_feature 262..345
/note="Region: EF-hand 1"
misc_feature 406..492
/note="Region: EF-hand 2"
misc_feature 772..1890
/note="Region: Carboxy-terminal region"
misc_feature 793..936
/note="Region: ZZ-domain"
misc_feature 1165..1317
/note="alpha1-syntrophin binding site"
misc_feature 1318..1440
/note="beta1-syntrophin binding site"
misc_feature 1318..1440
/note="Region: beta1-syntrophin binding site"
misc_feature 1507..1614
/note="Region: (Leu)6-heptad repeat"
3'UTR 1948..4552
polyA_signal 4530..4535
polyA_site 4552
BASE COUNT 1378 a 930 c 904 g 1340 t
ORIGIN
1 actttcgggg agcccggcgg ctctgggaag ctcactcctc cactcgtacc cacactcgac
61 cgcggagccc ttgcagccat gagggaacag ctcaaaggcc acgagactca aacaacttgc
121 tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga
181 ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat
241 ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac
301 cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag
361 caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg
421 ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc
481 atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg
541 gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc
601 caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt
661 gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta
721 gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct
781 gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt
841 ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt
901 tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg
961 actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc
1021 aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag
1081 ggggacaaca tggaaacgcc tgcctcgtcc cctcagcttt cacacgatga tactcattca
1141 cgcattgaac attatgctag caggctagca gaaatggaaa acagcaatgg atcttatcta
1201 aatgatagca tctctcctaa tgagagcata gatgatgaac atttgttaat ccagcattac
1261 tgccaaagtt tgaaccagga ctcccccctg agccagcctc gtagtcctgc ccagatcttg
1321 atttccttag agagtgagga aagaggggag ctagagagaa tcctagcaga tcttgaggaa
1381 gaaaacagga atctgcaagc agaatatgac cgtctaaagc agcagcacga acataaaggc
1441 ctgtccccac tgccgtcccc tcctgaaatg atgcccacct ctccccagag tccccgggat
1501 gctgagctca ttgctgaggc caagctactg cgtcaacaca aaggccgcct ggaagccagg
1561 atgcaaatcc tggaagacca caataaacag ctggagtcac agttacacag gctaaggcag
1621 ctgctggagc aaccccaggc agaggccaaa gtgaatggca caacggtgtc ctctccttct
1681 acctctctac agaggtccga cagcagtcag cctatgctgc tccgagtggt tggcagtcaa
1741 acttcggact ccatgggtga ggaagatctt ctcagtcctc cccaggacac aagcacaggg
1801 ttagaggagg tgatggagca actcaacaac tccttcccta gttcaagagg acacaatgta
1861 ggaagtcttt tccacatggc agatgatttg ggcagagcga tggagtcctt agtatcagtc
1921 atgacagatg aagaaggagc agaataaatg ttttacaact cctgattccc gcatggtttt
1981 tataatattc atacaacaaa gaggattaga cagtaagagt ttacaagaaa taaatctata
2041 tttttgtgaa gggtagtggt attatactgt agatttcagt agtttctaag tctgttattg
2101 ttttgttaac aatggcaggt tttacacgtc tatgcaattg tacaaaaaag ttataagaaa
2161 actacatgta aaatcttgat agctaaataa cttgccattt ctttatatgg aacgcatttt
2221 gggttgttta aaaatttata acagttataa agaaagattg taaactaaag tgtgctttat
2281 aaaaaaaagt tgtttataaa aacccctaaa aacaaaacaa acacacacac acacacatac
2341 acacacacac acaaaacttt gaggcagcgc attgttttgc atccttttgg cgtgatatcc
2401 atatgaaatt catggctttt tctttttttg catattaaag ataagacttc ctctaccacc
2461 acaccaaatg actactacac actgctcatt tgagaactgt cagctgagtg gggcaggctt
2521 gagttttcat ttcatatatc tatatgtcta taagtatata aatactatag ttatatagat
2581 aaagagatac gaatttctat agactgactt tttccatttt ttaaatgttc atgtcacatc
2641 ctaatagaaa gaaattactt ctagtcagtc atccaggctt acctgcttgg tctagaatgg
2701 atttttcccg gagccggaag ccaggaggaa actacaccac actaaaacat tgtctacagc
2761 tccagatgtt tctcatttta aacaactttc cactgacaac gaaagtaaag taaagtattg
2821 gattttttta aagggaacat gtgaatgaat acacaggact tattatatca gagtgagtaa
2881 tcggttggtt ggttgattga ttgattgatt gatacattca gcttcctgct gctagcaatg
2941 ccacgattta gatttaatga tgcttcagtg gaaatcaatc agaaggtatt ctgaccttgt
3001 gaacatcaga aggtattttt taactcccaa gcagtagcag gacgatgata gggctggagg
3061 gctatggatt cccagcccat ccctgtgaag gagtaggcca ctctttaagt gaaggattgg
3121 atgattgttc ataatacata aagttctctg taattacaac taaattatta tgccctcttc
3181 tcacagtcaa aaggaactgg gtggtttggt ttttgttgct tttttagatt tattgtccca
3241 tgtgggatga gtttttaaat gccacaagac ataatttaaa ataaataaac tttgggaaaa
3301 ggtgtaagac agtagcccca tcacatttgt gatactgaca ggtatcaacc cagaagccca
3361 tgaactgtgt ttccatcctt tgcatttctc tgcgagtagt tccacacagg tttgtaagta
3421 agtaagaaag aaggcaaatt gattcaaatg ttacaaaaaa acccttcttg gtggattaga
3481 caggttaaat atataaacaa acaaacaaaa attgctcaaa aaagaggaga aaagctcaag
3541 aggaaaagct aaggactggt aggaaaaagc tttactcttt catgccattt tatttctttt
3601 tgatttttaa atcattcatt caatagatac caccgtgtga cctataattt tgcaaatctg
3661 ttacctctga catcaagtgt aattagcttt tggagagtgg gctgacatca agtgtaatta
3721 gcttttggag agtgggtttt gtccattatt aataattaat taattaacat caaacacggc
3781 ttctcatgct atttctacct cactttggtt ttggggtgtt cctgataatt gtgcacacct
3841 gagttcacag cttcaccact tgtccattgc gttattttct ttttccttta taattctttc
3901 tttttccttc ataattttca aaagaaaacc caaagctcta aggtaacaaa ttaccaaatt
3961 acatgaagat ttggtttttg tcttgcattt ttttccttta tgtgacgctg gaccttttct
4021 ttacccaagg atttttaaaa ctcagattta aaacaagggg ttactttaca tcctactaag
4081 aagtttaagt aagtaagttt cattctaaaa tcagaggtaa atagagtgca taaataattt
4141 tgttttaatc tttttgtttt tcttttagac acattagctc tggagtgagt ctgtcataat
4201 atttgaacaa aaattgagag ctttattgct gcattttaag cataattaat ttggacatta
4261 tttcgtgttg tgttctttat aaccaccgag tattaaactg taaatcataa tgtaactgaa
4321 gcataaacat cacatggcat gttttgtcat tgttttcagg tactgagttc ttacttgagt
4381 atcataatat attgtgtttt aacaccaaca ctgtaacatt tacgaattat ttttttaaac
4441 ttcagtttta ctgcattttc acaacatatc agacttcacc aaatatatgc cttactattg
4501 tattatagta ctgctttact gtgtatctca ataaagcacg cagttatgtt ac
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