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Dystrophin isoform Dp427l (lymphocyte)

(last modified March 2, 1999)


Submitted to GenBank


LOCUS       Dp427l      13764 bp    mRNA            PRI       20-JAN-1998
DEFINITION  Human dystrophin cDNA isoform Dp427l (lymphocyte).
ACCESSION   Dp427l
KEYWORDS    .
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
            Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 46)
  AUTHORS   Nishio,H., Takeshima,Y., Narita,N., Yanagawa,H., Suzuki,Y.,
            Ishikawa,Y., Ishikawa,Y., Minami,R., Nakamura,H. and Matsuo,M.
  TITLE     Identification of a novel first exon in the human dystrophin gene
            and of a new promoter located more than 500 kb upstream of the
            nearest known promoter
  JOURNAL   J. Clin. Invest. 94, 1037-1042 (1994)
REFERENCE   2  (sites)
  AUTHORS   Muntoni,F., Melis,M.A., Ganau,A. and Dubowitz,V.
  TITLE     Transcription of the dystrophin gene in normal tissues and in
            skeletal muscle of a family with X-linked dilated cardiomyopathy
  JOURNAL   Am.J.Hum.Genet. 56, 151-157 (1995)
REFERENCE   3  (bases 1 to 13764)
  AUTHORS   den Dunnen,J.T.
  TITLE     Transcripts of the human dystrophin gene
  JOURNAL   Unpublished
  REMARK    More details regarding the nomenclature used, the annotations (e.g.
            proper references), RFLP's and mutations found in DMD, BMD and
            XLDCM patients, can be obtained from http://www.dmd.nl/
 
COMMENT     Constructed consensus sequence of D32048 and M18533.
FEATURES             Location/Qualifiers
     source          1..13764
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.2"
     5'UTR           <1..384
     misc_feature    47..108
                     /note="Nishio et al. state that bases 47-108 (dystrophin
                     exon 2) are not in the transcript, while Muntoni et al.
                     state they are"
                     /citation=[2]
                     /citation=[1]
     CDS             385..11073
                     /note="location of the translation initiation start is
                     unclear."
                     /codon_start=1
                     /product="dystrophin Dp427l"
                     /translation="MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGL
                     ALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDK
                     KSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLA
                     QGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNL
                     DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNI
                     LQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKL
                     KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV
                     VVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA
                     WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL
                     KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT
                     TREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF
                     AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS
                     EQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP
                     TAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV
                     FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRL
                     GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV
                     EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV
                     SDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK
                     GGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE
                     AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWH
                     ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILA
                     QTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQES
                     LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ
                     IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ
                     LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKV
                     TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKAT
                     QKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLL
                     EYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS
                     TRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQ
                     KLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKI
                     KQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR
                     DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQ
                     FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL
                     CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL
                     DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA
                     KYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK
                     QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKL
                     LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ
                     GEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA
                     VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAP
                     GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS
                     LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE
                     ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKL
                     ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM
                     ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
                     RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQR
                     RLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIG
                     GDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP
                     EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR
                     QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL
                     SPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISP
                     NKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLS
                     LSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL
                     NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDS
                     IQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLH
                     RVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMV
                     EYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINF
                     WPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQ
                     HYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQH
                     EHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQ
                     LHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS
                     PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"
     misc_feature    <385..735
                     /note="Region: Actin binding domain"
     misc_feature    772..9135
                     /note="Region: central rod domain"
                     772..9135
     misc_feature    772..996
                     /note="Region: hinge region 1"
     misc_feature    1024..1356
                     /note="Region: repeat region 1"
     misc_feature    1357..1683
                     /note="Region: repeat region 2"
     misc_feature    1684..2016
                     /note="Region: repeat region 3"
     misc_feature    2017..2166
                     /note="Region: hinge region 2"
     misc_feature    2167..2499
                     /note="Region: repeat region 4"
     misc_feature    2500..2817
                     /note="Region: repeat region 5"
     misc_feature    2818..3150
                     /note="Region: repeat region 6"
     misc_feature    3151..3477
                     /note="Region: repeat region 7"
     misc_feature    3478..3804
                     /note="Region: repeat region 8"
     misc_feature    3805..4116
                     /note="Region: repeat region 9"
     misc_feature    4021..4086
                     /note="Region: dystrophin Dp260-1 unique N-terminus"
     misc_feature    4117..4404
                     /note="Region: repeat region 10"
     misc_feature    4396..4719
                     /note="Region: repeat region 11"
     misc_feature    4720..5043
                     /note="Region: repeat region 12"
     misc_feature    5044..5349
                     /note="Region: repeat region 13"
     misc_feature    5350..5637
                     /note="Region: repeat region 14"
     misc_feature    5638..5934
                     /note="Region: repeat region 15"
     misc_feature    5989..6318
                     /note="Region: repeat region 16"
     misc_feature    6319..6639
                     /note="Region: repeat region 17"
     misc_feature    6640..6969
                     /note="Region: repeat region 18"
     misc_feature    6970..7284
                     /note="Region: repeat region 19"
     misc_feature    7285..7425
                     /note="Region: hinge region 3"
     misc_feature    7426..7746
                     /note="Region: repeat region 20"
     misc_feature    7747..8073
                     /note="Region: repeat region 21"
     misc_feature    8074..8421
                     /note="Region: repeat region 22"
     misc_feature    8422..8808
                     /note="Region: repeat region 23"
     misc_feature    8809..9135
                     /note="Region: repeat region 24"
     misc_feature    9055..9351
                     /note="Region: hinge region 4"
     misc_feature    9181..9291
                     /note="Region: WW-domain"
     misc_feature    9253..10239
                     /note="dystroglycan binding site"
     misc_feature    9313..9915
                     /note="Region: Cysteine-rich domain"
     misc_feature    9403..9486
                     /note="Region: EF-hand 1"
     misc_feature    9547..9633
                     /note="Region: EF-hand 2"
     misc_feature    9913..11070
                     /note="Region: Carboxy-terminal region"
     misc_feature    9934..10077
                     /note="Region: ZZ-domain"
     misc_feature    10345..10497
                     /note="alpha1-syntrophin binding site"
     misc_feature    10498..10620
                     /note="beta1-syntrophin binding site"
     misc_feature    10498..10620
                     /note="Region: beta1-syntrophin binding site"
     misc_feature    10687..10794
                     /note="Region: (Leu)6-heptad repeat"
     3'UTR           11074..13764
     polyA_signal    13742..13748
     polyA_site      13764
BASE COUNT     4550 a   2754 c   3076 g   3384 t
ORIGIN
        1 tcactgacac atagagtaac ttctagttct ccaagctcta ctcatgatga aagagaagat
       61 gttcaaaaga aaacattcac aaaatgggta aatgcacaat tttctaagtt tgggaagcag
      121 catattgaga acctcttcag tgacctacag gatgggaggc gcctcctaga cctcctcgaa
      181 ggcctgacag ggcaaaaact gccaaaagaa aaaggatcca caagagttca tgccctgaac
      241 aatgtcaaca aggcactgcg ggttttgcag aacaataatg ttgatttagt gaatattgga
      301 agtactgaca tcgtagatgg aaatcataaa ctgactcttg gtttgatttg gaatataatc
      361 ctccactggc aggtcaaaaa tgtaatgaaa aatatcatgg ctggattgca acaaaccaac
      421 agtgaaaaga ttctcctgag ctgggtccga caatcaactc gtaattatcc acaggttaat
      481 gtaatcaact tcaccaccag ctggtctgat ggcctggctt tgaatgctct catccatagt
      541 cataggccag acctatttga ctggaatagt gtggtttgcc agcagtcagc cacacaacga
      601 ctggaacatg cattcaacat cgccagatat caattaggca tagagaaact actcgatcct
      661 gaagatgttg ataccaccta tccagataag aagtccatct taatgtacat cacatcactc
      721 ttccaagttt tgcctcaaca agtgagcatt gaagccatcc aggaagtgga aatgttgcca
      781 aggccaccta aagtgactaa agaagaacat tttcagttac atcatcaaat gcactattct
      841 caacagatca cggtcagtct agcacaggga tatgagagaa cttcttcccc taagcctcga
      901 ttcaagagct atgcctacac acaggctgct tatgtcacca cctctgaccc tacacggagc
      961 ccatttcctt cacagcattt ggaagctcct gaagacaagt catttggcag ttcattgatg
     1021 gagagtgaag taaacctgga ccgttatcaa acagctttag aagaagtatt atcgtggctt
     1081 ctttctgctg aggacacatt gcaagcacaa ggagagattt ctaatgatgt ggaagtggtg
     1141 aaagaccagt ttcatactca tgaggggtac atgatggatt tgacagccca tcagggccgg
     1201 gttggtaata ttctacaatt gggaagtaag ctgattggaa caggaaaatt atcagaagat
     1261 gaagaaactg aagtacaaga gcagatgaat ctcctaaatt caagatggga atgcctcagg
     1321 gtagctagca tggaaaaaca aagcaattta catagagttt taatggatct ccagaatcag
     1381 aaactgaaag agttgaatga ctggctaaca aaaacagaag aaagaacaag gaaaatggag
     1441 gaagagcctc ttggacctga tcttgaagac ctaaaacgcc aagtacaaca acataaggtg
     1501 cttcaagaag atctagaaca agaacaagtc agggtcaatt ctctcactca catggtggtg
     1561 gtagttgatg aatctagtgg agatcacgca actgctgctt tggaagaaca acttaaggta
     1621 ttgggagatc gatgggcaaa catctgtaga tggacagaag accgctgggt tcttttacaa
     1681 gacatccttc tcaaatggca acgtcttact gaagaacagt gcctttttag tgcatggctt
     1741 tcagaaaaag aagatgcagt gaacaagatt cacacaactg gctttaaaga tcaaaatgaa
     1801 atgttatcaa gtcttcaaaa actggccgtt ttaaaagcgg atctagaaaa gaaaaagcaa
     1861 tccatgggca aactgtattc actcaaacaa gatcttcttt caacactgaa gaataagtca
     1921 gtgacccaga agacggaagc atggctggat aactttgccc ggtgttggga taatttagtc
     1981 caaaaacttg aaaagagtac agcacagatt tcacaggctg tcaccaccac tcagccatca
     2041 ctaacacaga caactgtaat ggaaacagta actacggtga ccacaaggga acagatcctg
     2101 gtaaagcatg ctcaagagga acttccacca ccacctcccc aaaagaagag gcagattact
     2161 gtggattctg aaattaggaa aaggttggat gttgatataa ctgaacttca cagctggatt
     2221 actcgctcag aagctgtgtt gcagagtcct gaatttgcaa tctttcggaa ggaaggcaac
     2281 ttctcagact taaaagaaaa agtcaatgcc atagagcgag aaaaagctga gaagttcaga
     2341 aaactgcaag atgccagcag atcagctcag gccctggtgg aacagatggt gaatgagggt
     2401 gttaatgcag atagcatcaa acaagcctca gaacaactga acagccggtg gatcgaattc
     2461 tgccagttgc taagtgagag acttaactgg ctggagtatc agaacaacat catcgctttc
     2521 tataatcagc tacaacaatt ggagcagatg acaactactg ctgaaaactg gttgaaaatc
     2581 caacccacca ccccatcaga gccaacagca attaaaagtc agttaaaaat ttgtaaggat
     2641 gaagtcaacc ggctatcagg tcttcaacct caaattgaac gattaaaaat tcaaagcata
     2701 gccctgaaag agaaaggaca aggacccatg ttcctggatg cagactttgt ggcctttaca
     2761 aatcatttta agcaagtctt ttctgatgtg caggccagag agaaagagct acagacaatt
     2821 tttgacactt tgccaccaat gcgctatcag gagaccatga gtgccatcag gacatgggtc
     2881 cagcagtcag aaaccaaact ctccatacct caacttagtg tcaccgacta tgaaatcatg
     2941 gagcagagac tcggggaatt gcaggcttta caaagttctc tgcaagagca acaaagtggc
     3001 ctatactatc tcagcaccac tgtgaaagag atgtcgaaga aagcgccctc tgaaattagc
     3061 cggaaatatc aatcagaatt tgaagaaatt gagggacgct ggaagaagct ctcctcccag
     3121 ctggttgagc attgtcaaaa gctagaggag caaatgaata aactccgaaa aattcagaat
     3181 cacatacaaa ccctgaagaa atggatggct gaagttgatg tttttctgaa ggaggaatgg
     3241 cctgcccttg gggattcaga aattctaaaa aagcagctga aacagtgcag acttttagtc
     3301 agtgatattc agacaattca gcccagtcta aacagtgtca atgaaggtgg gcagaagata
     3361 aagaatgaag cagagccaga gtttgcttcg agacttgaga cagaactcaa agaacttaac
     3421 actcagtggg atcacatgtg ccaacaggtc tatgccagaa aggaggcctt gaagggaggt
     3481 ttggagaaaa ctgtaagcct ccagaaagat ctatcagaga tgcacgaatg gatgacacaa
     3541 gctgaagaag agtatcttga gagagatttt gaatataaaa ctccagatga attacagaaa
     3601 gcagttgaag agatgaagag agctaaagaa gaggcccaac aaaaagaagc gaaagtgaaa
     3661 ctccttactg agtctgtaaa tagtgtcata gctcaagctc cacctgtagc acaagaggcc
     3721 ttaaaaaagg aacttgaaac tctaaccacc aactaccagt ggctctgcac taggctgaat
     3781 gggaaatgca agactttgga agaagtttgg gcatgttggc atgagttatt gtcatacttg
     3841 gagaaagcaa acaagtggct aaatgaagta gaatttaaac ttaaaaccac tgaaaacatt
     3901 cctggcggag ctgaggaaat ctctgaggtg ctagattcac ttgaaaattt gatgcgacat
     3961 tcagaggata acccaaatca gattcgcata ttggcacaga ccctaacaga tggcggagtc
     4021 atggatgagc taatcaatga ggaacttgag acatttaatt ctcgttggag ggaactacat
     4081 gaagaggctg taaggaggca aaagttgctt gaacagagca tccagtctgc ccaggagact
     4141 gaaaaatcct tacacttaat ccaggagtcc ctcacattca ttgacaagca gttggcagct
     4201 tatattgcag acaaggtgga cgcagctcaa atgcctcagg aagcccagaa aatccaatct
     4261 gatttgacaa gtcatgagat cagtttagaa gaaatgaaga aacataatca ggggaaggag
     4321 gctgcccaaa gagtcctgtc tcagattgat gttgcacaga aaaaattaca agatgtctcc
     4381 atgaagtttc gattattcca gaaaccagcc aattttgagc agcgtctaca agaaagtaag
     4441 atgattttag atgaagtgaa gatgcacttg cctgcattgg aaacaaagag tgtggaacag
     4501 gaagtagtac agtcacagct aaatcattgt gtgaacttgt ataaaagtct gagtgaagtg
     4561 aagtctgaag tggaaatggt gataaagact ggacgtcaga ttgtacagaa aaagcagacg
     4621 gaaaatccca aagaacttga tgaaagagta acagctttga aattgcatta taatgagctg
     4681 ggagcaaagg taacagaaag aaagcaacag ttggagaaat gcttgaaatt gtcccgtaag
     4741 atgcgaaagg aaatgaatgt cttgacagaa tggctggcag ctacagatat ggaattgaca
     4801 aagagatcag cagttgaagg aatgcctagt aatttggatt ctgaagttgc ctggggaaag
     4861 gctactcaaa aagagattga gaaacagaag gtgcacctga agagtatcac agaggtagga
     4921 gaggccttga aaacagtttt gggcaagaag gagacgttgg tggaagataa actcagtctt
     4981 ctgaatagta actggatagc tgtcacctcc cgagcagaag agtggttaaa tcttttgttg
     5041 gaataccaga aacacatgga aacttttgac cagaatgtgg accacatcac aaagtggatc
     5101 attcaggctg acacactttt ggatgaatca gagaaaaaga aaccccagca aaaagaagac
     5161 gtgcttaagc gtttaaaggc agaactgaat gacatacgcc caaaggtgga ctctacacgt
     5221 gaccaagcag caaacttgat ggcaaaccgc ggtgaccact gcaggaaatt agtagagccc
     5281 caaatctcag agctcaacca tcgatttgca gccatttcac acagaattaa gactggaaag
     5341 gcctccattc ctttgaagga attggagcag tttaactcag atatacaaaa attgcttgaa
     5401 ccactggagg ctgaaattca gcagggggtg aatctgaaag aggaagactt caataaagat
     5461 atgaatgaag acaatgaggg tactgtaaaa gaattgttgc aaagaggaga caacttacaa
     5521 caaagaatca cagatgagag aaagcgagag gaaataaaga taaaacagca gctgttacag
     5581 acaaaacata atgctctcaa ggatttgagg tctcaaagaa gaaaaaaggc tctagaaatt
     5641 tctcatcagt ggtatcagta caagaggcag gctgatgatc tcctgaaatg cttggatgac
     5701 attgaaaaaa aattagccag cctacctgag cccagagatg aaaggaaaat aaaggaaatt
     5761 gatcgggaat tgcagaagaa gaaagaggag ctgaatgcag tgcgtaggca agctgagggc
     5821 ttgtctgagg atggggccgc aatggcagtg gagccaactc agatccagct cagcaagcgc
     5881 tggcgggaaa ttgagagcaa atttgctcag tttcgaagac tcaactttgc acaaattcac
     5941 actgtccgtg aagaaacgat gatggtgatg actgaagaca tgcctttgga aatttcttat
     6001 gtgccttcta cttatttgac tgaaatcact catgtctcac aagccctatt agaagtggaa
     6061 caacttctca atgctcctga cctctgtgct aaggactttg aagatctctt taagcaagag
     6121 gagtctctga agaatataaa agatagtcta caacaaagct caggtcggat tgacattatt
     6181 catagcaaga agacagcagc attgcaaagt gcaacgcctg tggaaagggt gaagctacag
     6241 gaagctctct cccagcttga tttccaatgg gaaaaagtta acaaaatgta caaggaccga
     6301 caagggcgat ttgacagatc tgttgagaaa tggcggcgtt ttcattatga tataaagata
     6361 tttaatcagt ggctaacaga agctgaacag tttctcagaa agacacaaat tcctgagaat
     6421 tgggaacatg ctaaatacaa atggtatctt aaggaactcc aggatggcat tgggcagcgg
     6481 caaactgttg tcagaacatt gaatgcaact ggggaagaaa taattcagca atcctcaaaa
     6541 acagatgcca gtattctaca ggaaaaattg ggaagcctga atctgcggtg gcaggaggtc
     6601 tgcaaacagc tgtcagacag aaaaaagagg ctagaagaac aaaagaatat cttgtcagaa
     6661 tttcaaagag atttaaatga atttgtttta tggttggagg aagcagataa cattgctagt
     6721 atcccacttg aacctggaaa agagcagcaa ctaaaagaaa agcttgagca agtcaagtta
     6781 ctggtggaag agttgcccct gcgccaggga attctcaaac aattaaatga aactggagga
     6841 cccgtgcttg taagtgctcc cataagccca gaagagcaag ataaacttga aaataagctc
     6901 aagcagacaa atctccagtg gataaaggtt tccagagctt tacctgagaa acaaggagaa
     6961 attgaagctc aaataaaaga ccttgggcag cttgaaaaaa agcttgaaga ccttgaagag
     7021 cagttaaatc atctgctgct gtggttatct cctattagga atcagttgga aatttataac
     7081 caaccaaacc aagaaggacc atttgacgtt caggaaactg aaatagcagt tcaagctaaa
     7141 caaccggatg tggaagagat tttgtctaaa gggcagcatt tgtacaagga aaaaccagcc
     7201 actcagccag tgaagaggaa gttagaagat ctgagctctg agtggaaggc ggtaaaccgt
     7261 ttacttcaag agctgagggc aaagcagcct gacctagctc ctggactgac cactattgga
     7321 gcctctccta ctcagactgt tactctggtg acacaacctg tggttactaa ggaaactgcc
     7381 atctccaaac tagaaatgcc atcttccttg atgttggagg tacctgctct ggcagatttc
     7441 aaccgggctt ggacagaact taccgactgg ctttctctgc ttgatcaagt tataaaatca
     7501 cagagggtga tggtgggtga ccttgaggat atcaacgaga tgatcatcaa gcagaaggca
     7561 acaatgcagg atttggaaca gaggcgtccc cagttggaag aactcattac cgctgcccaa
     7621 aatttgaaaa acaagaccag caatcaagag gctagaacaa tcattacgga tcgaattgaa
     7681 agaattcaga atcagtggga tgaagtacaa gaacaccttc agaaccggag gcaacagttg
     7741 aatgaaatgt taaaggattc aacacaatgg ctggaagcta aggaagaagc tgagcaggtc
     7801 ttaggacagg ccagagccaa gcttgagtca tggaaggagg gtccctatac agtagatgca
     7861 atccaaaaga aaatcacaga aaccaagcag ttggccaaag acctccgcca gtggcagaca
     7921 aatgtagatg tggcaaatga cttggccctg aaacttctcc gggattattc tgcagatgat
     7981 accagaaaag tccacatgat aacagagaat atcaatgcct cttggagaag cattcataaa
     8041 agggtgagtg agcgagaggc tgctttggaa gaaactcata gattactgca acagttcccc
     8101 ctggacctgg aaaagtttct tgcctggctt acagaagctg aaacaactgc caatgtccta
     8161 caggatgcta cccgtaagga aaggctccta gaagactcca agggagtaaa agagctgatg
     8221 aaacaatggc aagacctcca aggtgaaatt gaagctcaca cagatgttta tcacaacctg
     8281 gatgaaaaca gccaaaaaat cctgagatcc ctggaaggtt ccgatgatgc agtcctgtta
     8341 caaagacgtt tggataacat gaacttcaag tggagtgaac ttcggaaaaa gtctctcaac
     8401 attaggtccc atttggaagc cagttctgac cagtggaagc gtctgcacct ttctctgcag
     8461 gaacttctgg tgtggctaca gctgaaagat gatgaattaa gccggcaggc acctattgga
     8521 ggcgactttc cagcagttca gaagcagaac gatgtacata gggccttcaa gagggaattg
     8581 aaaactaaag aacctgtaat catgagtact cttgagactg tacgaatatt tctgacagag
     8641 cagcctttgg aaggactaga gaaactctac caggagccca gagagctgcc tcctgaggag
     8701 agagcccaga atgtcactcg gcttctacga aagcaggctg aggaggtcaa tactgagtgg
     8761 gaaaaattga acctgcactc cgctgactgg cagagaaaaa tagatgagac ccttgaaaga
     8821 ctccaggaac ttcaagaggc cacggatgag ctggacctca agctgcgcca agctgaggtg
     8881 atcaagggat cctggcagcc cgtgggcgat ctcctcattg actctctcca agatcacctc
     8941 gagaaagtca aggcacttcg aggagaaatt gcgcctctga aagagaacgt gagccacgtc
     9001 aatgaccttg ctcgccagct taccactttg ggcattcagc tctcaccgta taacctcagc
     9061 actctggaag acctgaacac cagatggaag cttctgcagg tggccgtcga ggaccgagtc
     9121 aggcagctgc atgaagccca cagggacttt ggtccagcat ctcagcactt tctttccacg
     9181 tctgtccagg gtccctggga gagagccatc tcgccaaaca aagtgcccta ctatatcaac
     9241 cacgagactc aaacaacttg ctgggaccat cccaaaatga cagagctcta ccagtcttta
     9301 gctgacctga ataatgtcag attctcagct tataggactg ccatgaaact ccgaagactg
     9361 cagaaggccc tttgcttgga tctcttgagc ctgtcagctg catgtgatgc cttggaccag
     9421 cacaacctca agcaaaatga ccagcccatg gatatcctgc agattattaa ttgtttgacc
     9481 actatttatg accgcctgga gcaagagcac aacaatttgg tcaacgtccc tctctgcgtg
     9541 gatatgtgtc tgaactggct gctgaatgtt tatgatacgg gacgaacagg gaggatccgt
     9601 gtcctgtctt ttaaaactgg catcatttcc ctgtgtaaag cacatttgga agacaagtac
     9661 agataccttt tcaagcaagt ggcaagttca acaggatttt gtgaccagcg caggctgggc
     9721 ctccttctgc atgattctat ccaaattcca agacagttgg gtgaagttgc atcctttggg
     9781 ggcagtaaca ttgagccaag tgtccggagc tgcttccaat ttgctaataa taagccagag
     9841 atcgaagcgg ccctcttcct agactggatg agactggaac cccagtccat ggtgtggctg
     9901 cccgtcctgc acagagtggc tgctgcagaa actgccaagc atcaggccaa atgtaacatc
     9961 tgcaaagagt gtccaatcat tggattcagg tacaggagtc taaagcactt taattatgac
    10021 atctgccaaa gctgcttttt ttctggtcga gttgcaaaag gccataaaat gcactatccc
    10081 atggtggaat attgcactcc gactacatca ggagaagatg ttcgagactt tgccaaggta
    10141 ctaaaaaaca aatttcgaac caaaaggtat tttgcgaagc atccccgaat gggctacctg
    10201 ccagtgcaga ctgtcttaga gggggacaac atggaaactc ccgttactct gatcaacttc
    10261 tggccagtag attctgcgcc tgcctcgtcc cctcagcttt cacacgatga tactcattca
    10321 cgcattgaac attatgctag caggctagca gaaatggaaa acagcaatgg atcttatcta
    10381 aatgatagca tctctcctaa tgagagcata gatgatgaac atttgttaat ccagcattac
    10441 tgccaaagtt tgaaccagga ctcccccctg agccagcctc gtagtcctgc ccagatcttg
    10501 atttccttag agagtgagga aagaggggag ctagagagaa tcctagcaga tcttgaggaa
    10561 gaaaacagga atctgcaagc agaatatgac cgtctaaagc agcagcacga acataaaggc
    10621 ctgtccccac tgccgtcccc tcctgaaatg atgcccacct ctccccagag tccccgggat
    10681 gctgagctca ttgctgaggc caagctactg cgtcaacaca aaggccgcct ggaagccagg
    10741 atgcaaatcc tggaagacca caataaacag ctggagtcac agttacacag gctaaggcag
    10801 ctgctggagc aaccccaggc agaggccaaa gtgaatggca caacggtgtc ctctccttct
    10861 acctctctac agaggtccga cagcagtcag cctatgctgc tccgagtggt tggcagtcaa
    10921 acttcggact ccatgggtga ggaagatctt ctcagtcctc cccaggacac aagcacaggg
    10981 ttagaggagg tgatggagca actcaacaac tccttcccta gttcaagagg aagaaatacc
    11041 cctggaaagc caatgagaga ggacacaatg taggaagtct tttccacatg gcagatgatt
    11101 tgggcagagc gatggagtcc ttagtatcag tcatgacaga tgaagaagga gcagaataaa
    11161 tgttttacaa ctcctgattc ccgcatggtt tttataatat tcatacaaca aagaggatta
    11221 gacagtaaga gtttacaaga aataaatcta tatttttgtg aagggtagtg gtattatact
    11281 gtagatttca gtagtttcta agtctgttat tgttttgtta acaatggcag gttttacacg
    11341 tctatgcaat tgtacaaaaa agttataaga aaactacatg taaaatcttg atagctaaat
    11401 aacttgccat ttctttatat ggaacgcatt ttgggttgtt taaaaattta taacagttat
    11461 aaagaaagat tgtaaactaa agtgtgcttt ataaaaaaaa gttgtttata aaaaccccta
    11521 aaaacaaaac aaacacacac acacacacat acacacacac acacaaaact ttgaggcagc
    11581 gcattgtttt gcatcctttt ggcgtgatat ccatatgaaa ttcatggctt tttctttttt
    11641 tgcatattaa agataagact tcctctacca ccacaccaaa tgactactac acactgctca
    11701 tttgagaact gtcagctgag tggggcaggc ttgagttttc atttcatata tctatatgtc
    11761 tataagtata taaatactat agttatatag ataaagagat acgaatttct atagactgac
    11821 tttttccatt ttttaaatgt tcatgtcaca tcctaataga aagaaattac ttctagtcag
    11881 tcatccaggc ttacctgctt ggtctagaat ggatttttcc cggagccgga agccaggagg
    11941 aaactacacc acactaaaac attgtctaca gctccagatg tttctcattt taaacaactt
    12001 tccactgaca acgaaagtaa agtaaagtat tggatttttt taaagggaac atgtgaatga
    12061 atacacagga cttattatat cagagtgagt aatcggttgg ttggttgatt gattgattga
    12121 ttgatacatt cagcttcctg ctgctagcaa tgccacgatt tagatttaat gatgcttcag
    12181 tggaaatcaa tcagaaggta ttctgacctt gtgaacatca gaaggtattt tttaactccc
    12241 aagcagtagc aggacgatga tagggctgga gggctatgga ttcccagccc atccctgtga
    12301 aggagtaggc cactctttaa gtgaaggatt ggatgattgt tcataataca taaagttctc
    12361 tgtaattaca actaaattat tatgccctct tctcacagtc aaaaggaact gggtggtttg
    12421 gtttttgttg cttttttaga tttattgtcc catgtgggat gagtttttaa atgccacaag
    12481 acataattta aaataaataa actttgggaa aaggtgtaag acagtagccc catcacattt
    12541 gtgatactga caggtatcaa cccagaagcc catgaactgt gtttccatcc tttgcatttc
    12601 tctgcgagta gttccacaca ggtttgtaag taagtaagaa agaaggcaaa ttgattcaaa
    12661 tgttacaaaa aaacccttct tggtggatta gacaggttaa atatataaac aaacaaacaa
    12721 aaattgctca aaaaagagga gaaaagctca agaggaaaag ctaaggactg gtaggaaaaa
    12781 gctttactct ttcatgccat tttatttctt tttgattttt aaatcattca ttcaatagat
    12841 accaccgtgt gacctataat tttgcaaatc tgttacctct gacatcaagt gtaattagct
    12901 tttggagagt gggctgacat caagtgtaat tagcttttgg agagtgggtt ttgtccatta
    12961 ttaataatta attaattaac atcaaacacg gcttctcatg ctatttctac ctcactttgg
    13021 ttttggggtg ttcctgataa ttgtgcacac ctgagttcac agcttcacca cttgtccatt
    13081 gcgttatttt ctttttcctt tataattctt tctttttcct tcataatttt caaaagaaaa
    13141 cccaaagctc taaggtaaca aattaccaaa ttacatgaag atttggtttt tgtcttgcat
    13201 ttttttcctt tatgtgacgc tggacctttt ctttacccaa ggatttttaa aactcagatt
    13261 taaaacaagg ggttacttta catcctacta agaagtttaa gtaagtaagt ttcattctaa
    13321 aatcagaggt aaatagagtg cataaataat tttgttttaa tctttttgtt tttcttttag
    13381 acacattagc tctggagtga gtctgtcata atatttgaac aaaaattgag agctttattg
    13441 ctgcatttta agcataatta atttggacat tatttcgtgt tgtgttcttt ataaccaccg
    13501 agtattaaac tgtaaatcat aatgtaactg aagcataaac atcacatggc atgttttgtc
    13561 attgttttca ggtactgagt tcttacttga gtatcataat atattgtgtt ttaacaccaa
    13621 cactgtaaca tttacgaatt atttttttaa acttcagttt tactgcattt tcacaacata
    13681 tcagacttca ccaaatatat gccttactat tgtattatag tactgcttta ctgtgtatct
    13741 caataaagca cgcagttatg ttac


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