LOCUS NG_008376 8953 bp DNA linear PRI 03-JUL-2014 DEFINITION Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), RefSeqGene on chromosome 22. ACCESSION NG_008376 VERSION NG_008376.3 GI:507834151 KEYWORDS RefSeq; RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 8953) AUTHORS Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM and Nebert DW. TITLE Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants JOURNAL Pharmacogenetics 14 (1), 1-18 (2004) PUBMED 15128046 REMARK Review article COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Sarah Sim, Johan den Dunnen. The reference sequence was derived from AY545216.1. This sequence is a reference standard in the RefSeqGene project. On May 30, 2013 this sequence version replaced gi:392583869. Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-8953 AY545216.1 1-8953 FEATURES Location/Qualifiers source 1..8953 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="22" /map="22q13.1" gene 4111..8493 /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /note="cytochrome P450, family 2, subfamily D, polypeptide 6" /db_xref="GeneID:1565" /db_xref="HGNC:HGNC:2625" /db_xref="MIM:124030" mRNA join(4111..4380,5083..5254,5807..5959,6048..6208, 6642..6818,7009..7150,7358..7545,8000..8141,8240..8493) /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /product="cytochrome P450, family 2, subfamily D, polypeptide 6, transcript variant 1" /transcript_id="NM_000106.5" /db_xref="GI:392513720" /db_xref="GeneID:1565" /db_xref="HGNC:HGNC:2625" /db_xref="MIM:124030" exon 4111..4380 /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /inference="alignment:Splign:1.39.8" /number=1 CDS join(4201..4380,5083..5254,5807..5959,6048..6208, 6642..6818,7009..7150,7358..7545,8000..8141,8240..8418) /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /EC_number="1.14.14.1" /note="isoform 1 is encoded by transcript variant 1; debrisoquine 4-hydroxylase; microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450 2D6; cytochrome P450-DB1" /codon_start=1 /product="cytochrome P450 2D6 isoform 1" /protein_id="NP_000097.3" /db_xref="GI:392513721" /db_xref="CCDS:CCDS46721.1" /db_xref="GeneID:1565" /db_xref="HGNC:HGNC:2625" /db_xref="MIM:124030" /translation="MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLG NLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRP PVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACL CAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESG FLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFL AEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQE IDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKG TTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLAR MELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR" exon 5083..5254 /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /inference="alignment:Splign:1.39.8" /number=2 exon 5807..5959 /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /inference="alignment:Splign:1.39.8" /number=3 exon 6048..6208 /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /inference="alignment:Splign:1.39.8" /number=4 exon 6642..6818 /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /inference="alignment:Splign:1.39.8" /number=5 exon 7009..7150 /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /inference="alignment:Splign:1.39.8" /number=6 exon 7358..7545 /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /inference="alignment:Splign:1.39.8" /number=7 exon 8000..8141 /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /inference="alignment:Splign:1.39.8" /number=8 exon 8240..8493 /gene="CYP2D6" /gene_synonym="CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1" /inference="alignment:Splign:1.39.8" /number=9 ORIGIN 1 attacagcct tctgagtcac tgacactaca ggtgtgagcc accatgtcca gcttgtagtg 61 gttttgaaca gctcttgccc cttcttggga atctaggtgc cctgcacgtg ggtaaggctg 121 tctgcagctg tgcccatatt caggaaggcc ggcaaggccc tgagccctca cacgtgactg 181 acctgaggtg ctgtgcagac agcaggtgac ggctaaggga aagttgagca ctgcctagcc 241 gagcactgaa gccacgcccg gcacacagag agagacccac tcggcaaaga cttcgcttcc 301 aggcacctaa ggaactctct gaccagtcat tagctgacca ctgccgtaac tgaagagcgg 361 cttcagtggc cacagctcgc agggaatgga gacattaatg cttagtcaga attagttcag 421 aaaagtcacc cagcaaagaa acagctccaa caggcaacaa caacaacaca tccttggcag 481 ggaagagaat ctgacttccg gagttgccac attatcgccc gtgaaatgtc caggttttaa 541 caaattatga gacatggaaa ggaaaccgaa aggacgaccc agacacggga aaagtcacca 601 atgggaccag cccgatgctg caattgctag acaaagacgt tcagtcagct catttaaata 661 tgttcaaaga cctaaaacat gctgcatctg aggctgcacc ggctggaacc tgctgatctc 721 ggaagctaag catggtcagg cctggctagt acttcaaagg gagaaaccac gtgtaggcct 781 ggtgcagtgg ctcacaccta taatcctagc actctgggaa gctgaggccc gtggattgct 841 tgagcccagg agtttgagag cagcttggga aatgtggtga gacccccatc tctacaaaaa 901 aatttaaaaa attagctggc tgcctatggt cccagcctct caggatgctg aggtaggagg 961 atcacttcag cccaggaagt tgaggctgca gtgagccatg actgcatcac tgcactccag 1021 cttgggcgac agagagaccc tctcccaaga aaaagaaaag aaccatgtca aaagaactaa 1081 cgaaagtgtg ggaacaatgt ctcaccaatt agagaatatc aataatggga tgaaccttat 1141 aaaaaggggc tgggcatggt ggctcatgcc tataatccca gcactttggg aggctgaggc 1201 gggcatatca tgaggtcaag agattgagac cagcctggcc aacatggtga aaccccgtct 1261 ctacttaaaa tacaaaaatt agccgggcgt ggtggcacgt gcctgtaatc ccagctactc 1321 gggaggctga ggcaggagaa tcgcttgaac ccgagaggca gagattgcag tgagccgaga 1381 ttgcaccact gcactacagc ctgggtgaca gagcgatact ccaaaaaaca aaacaaaaca 1441 aaaaacaaaa aaaaagttta aaaaggaacc aaataaaaat tctggagttg tagggtaaaa 1501 taaatgaaaa ttcatcccag gggcccaaga gcagattgga acaattggaa gaaagagcct 1561 gtgactatgg agagaggcca cctgaggtag taccctctga ggaacaggaa caagcatgaa 1621 gagcaatgca cagagatcca gagacctgga gacgccgtca agctttccga catacacgca 1681 atgggagtcc caggaaagaa gacagggaga aaggagtaaa ggaatagttg aagaattaat 1741 ggctgaaaaa cctcccaaat ctgatgaaaa atattaatct gtacatccaa aaagctcatc 1801 aaactccaag tagggtaaac tcaaagagat cttcagccat acgcatcatc ataatcactg 1861 tcaaaagaca gatttttctt tttttagaat tttaaatgta ccttttaatt tgctcctggg 1921 gcaaagagcc aggactggta ctagagcagt gtctgggatg agaagaattt aataaaatgg 1981 gattaggtcc aatggttggg ttaggggagg caacctgctc gggaggatca gcctcaacct 2041 atccatgcag cagggcctcc acctgtccct ctccgtagtc ccacacctgg aacccagagc 2101 catctgcctc ttcccagatc atggccgaca gcactccacc agactgcggc tggagcaggc 2161 acaggattca cttattgagg gctgtggcct ggcacagatc atagcctata cccagggaca 2221 gttgtgtcac ttctgccacc accacatccg ccttctgcag ccacatcaag taccactcat 2281 ggatgagccc gtcaccccca gcggacttat caaccccgcg tccagctcca cagccgccac 2341 gtgctcggtg agcactggct ccaagcatgg cagctgccat acaatccacc tgtagagggc 2401 ccggtcctcc tgtcctcagt ggatgatccc gtagaagtcc agagctcggc agctgccctc 2461 ccacaaaaga caggattttg aaagcagcaa gagagaagag acgtatcagg tagtcacagt 2521 ggctcaggcc tgtaatccca gcactttggg aggcccaggt gggaggatcg cttcacccca 2581 ggaattcaag accagcctgg acaacttgga agaacccggt ctctacaaaa aatacaaaat 2641 tagctgggat tgggtgcggt ggctcatgcc tataatccca gcactttggg agcctgaggt 2701 gggtggatca cctgaagtca ggagttcaag actagcctgg ccaacatggt gaaaccctat 2761 ctctactgaa aatacaaaaa gctagacgtg gtggcacaca cctgtaatcc cagctactta 2821 ggaggctgag gcaggagaat tgcttgaagc ctagaggtga aggttgtagt gagccgagat 2881 tgcatcattg cacaatggag gggagccacc agcctgggca acaagaggaa atctccgtct 2941 ccaaaaaaaa aaaaaaaaaa aaaagaatta ggctgggtgg tgcctgtagt cccagctact 3001 tgggaggcag ggggtccact tgatgtcgag actgcagtga gccatgatcc tgccactgca 3061 ctccggcctg ggcaacagag tgagaccctg tctaaagaaa aaaaaaataa agcaacatat 3121 cctgaacaaa ggatcctcca taacgttccc accagatttc taatcagaaa catggaggcc 3181 agaaagcagt ggaggaggac gaccctcagg cagcccggga ggatgttgtc acaggctggg 3241 gcaagggcct tccggctacc aactgggagc tctgggaaca gccctgttgc aaacaagaag 3301 ccatagcccg gccagagccc aggaatgtgg gctgggctgg gagcagcctc tggacaggag 3361 tggtcccatc caggaaacct ccggcatggc tgggaagtgg ggtacttggt gccgggtctg 3421 tatgtgtgtg tgactggtgt gtgtgagaga gaatgtgtgc cctaagtgtc agtgtgagtc 3481 tgtgtatgtg tgaatattgt ctttgtgtgg gtgattttct gcgtgtgtaa tcgtgtccct 3541 gcaagtgtga acaagtggac aagtgtctgg gagtggacaa gagatctgtg caccatcagg 3601 tgtgtgcata gcgtctgtgc atgtcaagag tgcaaggtga agtgaaggga ccaggcccat 3661 gatgccactc atcatcagga gctctaaggc cccaggtaag tgccagtgac agataagggt 3721 gctgaaggtc actctggagt gggcaggtgg gggtagggaa agggcaaggc catgttctgg 3781 aggaggggtt gtgactacat tagggtgtat gagcctagct gggaggtgga tggccgggtc 3841 cactgaaacc ctggttatcc cagaaggctt tgcaggcttc aggagcttgg agtggggaga 3901 gggggtgact tctccgacca ggcccctcca ccggcctacc ctgggtaagg gcctggagca 3961 ggaagcaggg gcaagaacct ctggagcagc ccatacccgc cctggcctga ctctgccact 4021 ggcagcacag tcaacacagc aggttcactc acagcagagg gcaaaggcca tcatcagctc 4081 cctttataag ggaagggtca cgcgctcggt gtgctgagag tgtcctgcct ggtcctctgt 4141 gcctggtggg gtgggggtgc caggtgtgtc cagaggagcc catttggtag tgaggcaggt 4201 atggggctag aagcactggt gcccctggcc gtgatagtgg ccatcttcct gctcctggtg 4261 gacctgatgc accggcgcca acgctgggct gcacgctacc caccaggccc cctgccactg 4321 cccgggctgg gcaacctgct gcatgtggac ttccagaaca caccatactg cttcgaccag 4381 gtgagggagg aggtcctgga gggcggcaga ggtgctgagg ctcccctacc agaagcaaac 4441 atggatggtg ggtgaaacca caggctggac cagaagccag gctgagaagg ggaagcaggt 4501 ttgggggacg tcctggagaa gggcatttat acatggcatg aaggactgga ttttccaaag 4561 gccaaggaag agtagggcaa gggcctggag gtggagctgg acttggcagt gggcatgcaa 4621 gcccattggg caacatatgt tatggagtac aaagtccctt ctgctgacac cagaaggaaa 4681 ggccttggga atggaagatg agttagtcct gagtgccgtt taaatcacga aatcgaggat 4741 gaagggggtg cagtgacccg gttcaaacct tttgcactgt gggtcctcgg gcctcactgc 4801 tcaccggcat ggaccatcat ctgggaatgg gatgctaact ggggcctctc ggcaattttg 4861 gtgactcttg caaggtcata cctgggtgac gcatccaaac tgagttcctc catcacagaa 4921 ggtgtgaccc ccacccccgc cccacgatca ggaggctggg tctcctcctt ccacctgctc 4981 actcctggta gccccggggg tcgtccaagg ttcaaatagg actaggacct gtagtctggg 5041 gtgatcctgg cttgacaaga ggccctgacc ctccctctgc agttgcggcg ccgcttcggg 5101 gacgtgttca gcctgcagct ggcctggacg ccggtggtcg tgctcaatgg gctggcggcc 5161 gtgcgcgagg cgctggtgac ccacggcgag gacaccgccg accgcccgcc tgtgcccatc 5221 acccagatcc tgggtttcgg gccgcgttcc caaggcaagc agcggtgggg acagagacag 5281 atttccgtgg gacccgggtg ggtgatgacc gtagtccgag ctgggcagag agggcgcggg 5341 gtcgtggaca tgaaacaggc cagcgagtgg ggacagcggg ccaagaaacc acctgcacta 5401 gggaggtgtg agcatgggga cgagggcggg gcttgtgacg agtgggcggg gccactgccg 5461 agacctggca ggagcccaat gggtgaggct ggcgcatttc ccagctggaa tccggtgtcg 5521 aagtgggggg cggggaccgc acctgtgctg taagctcagt gtgggtggcg cggggcccgc 5581 ggggtcttcc ctgagtgcaa aggcggtcag ggtgggcaga gacgaggtgg ggcaaagccc 5641 tgccccagcc aagggagcaa ggtggatgca caaagagtgg gccctgtgac cagctggaca 5701 gagccaggga ctgcgggaga ccagggggag catagggttg gagtgggtgg tggatggtgg 5761 ggctaatgcc ttcatggcca cgcgcacgtg cccgtcccac ccccaggggt gttcctggcg 5821 cgctatgggc ccgcgtggcg cgagcagagg cgcttctccg tgtccacctt gcgcaacttg 5881 ggcctgggca agaagtcgct ggagcagtgg gtgaccgagg aggccgcctg cctttgtgcc 5941 gccttcgcca accactccgg tgggtgatgg gcagaagggc acaaagcggg aactgggaag 6001 gcgggggacg gggaaggcga ccccttaccc gcatctccca cccccaggac gcccctttcg 6061 ccccaacggt ctcttggaca aagccgtgag caacgtgatc gcctccctca cctgcgggcg 6121 ccgcttcgag tacgacgacc ctcgcttcct caggctgctg gacctagctc aggagggact 6181 gaaggaggag tcgggctttc tgcgcgaggt gcggagcgag agaccgagga gtctctgcag 6241 ggcgagctcc cgagaggtgc cggggctgga ctggggcctc ggaagagcag gatttgcata 6301 gatgggtttg ggaaaggaca ttccaggaga ccccactgta agaagggcct ggaggaggag 6361 gggacatctc agacatggtc gtgggagagg tgtgcccggg tcagggggca ccaggagagg 6421 ccaaggactc tgtacctcct atccacgtca gagatttcga ttttaggttt ctcctctggg 6481 caaggagaga gggtggaggc tggcacttgg ggagggactt ggtgaggtca gtggtaagga 6541 caggcaggcc ctgggtctac ctggagatgg ctggggcctg agacttgtcc aggtgaacgc 6601 agagcacagg agggattgag accccgttct gtctggtgta ggtgctgaat gctgtccccg 6661 tcctcctgca tatcccagcg ctggctggca aggtcctacg cttccaaaag gctttcctga 6721 cccagctgga tgagctgcta actgagcaca ggatgacctg ggacccagcc cagccccccc 6781 gagacctgac tgaggccttc ctggcagaga tggagaaggt gagagtggct gccacggtgg 6841 ggggcaaggg tggtgggttg agcgtcccag gaggaatgag gggaggctgg gcaaaaggtt 6901 ggaccagtgc atcacccggc gagccgcatc tgggctgaca ggtgcagaat tggaggtcat 6961 ttgggggcta ccccgttctg tcccgagtat gctctcggcc ctgctcaggc caaggggaac 7021 cctgagagca gcttcaatga tgagaacctg cgcatagtgg tggctgacct gttctctgcc 7081 gggatggtga ccacctcgac cacgctggcc tggggcctcc tgctcatgat cctacatccg 7141 gatgtgcagc gtgagcccat ctgggaaaca gtgcaggggc cgagggagga agggtacagg 7201 cgggggccca tgaactttgc tgggacaccc ggggctccaa gcacaggctt gaccaggatc 7261 ctgtaagcct gacctcctcc aacataggag gcaagaagga gtgtcagggc cggaccccct 7321 gggtgctgac ccattgtggg gacgcatgtc tgtccaggcc gtgtccaaca ggagatcgac 7381 gacgtgatag ggcaggtgcg gcgaccagag atgggtgacc aggctcacat gccctacacc 7441 actgccgtga ttcatgaggt gcagcgcttt ggggacatcg tccccctggg tgtgacccat 7501 atgacatccc gtgacatcga agtacagggc ttccgcatcc ctaaggtagg cctggcgccc 7561 tcctcacccc agctcagcac cagcacctgg tgatagcccc agcatggcta ctgccaggtg 7621 ggcccactct aggaaccctg gccacctagt cctcaatgcc accacactga ctgtccccac 7681 ttgggtgggg ggtccagagt ataggcaggg ctggcctgtc catccagagc ccccgtctag 7741 tggggagaca aaccaggacc tgccagaatg ttggaggacc caacgcctgc agggagaggg 7801 ggcagtgtgg gtgcctctga gaggtgtgac tgcgccctgc tgtggggtcg gagagggtac 7861 tgtggagctt ctcgggcgca ggactagttg acagagtcca gctgtgtgcc aggcagtgtg 7921 tgtcccccgt gtgtttggtg gcaggggtcc cagcatccta gagtccagtc cccactctca 7981 ccctgcatct cctgcccagg gaacgacact catcaccaac ctgtcatcgg tgctgaagga 8041 tgaggccgtc tgggagaagc ccttccgctt ccaccccgaa cacttcctgg atgcccaggg 8101 ccactttgtg aagccggagg ccttcctgcc tttctcagca ggtgcctgtg gggagcccgg 8161 ctccctgtcc ccttccgtgg agtcttgcag gggtatcacc caggagccag gctcactgac 8221 gcccctcccc tccccacagg ccgccgtgca tgcctcgggg agcccctggc ccgcatggag 8281 ctcttcctct tcttcacctc cctgctgcag cacttcagct tctcggtgcc cactggacag 8341 ccccggccca gccaccatgg tgtctttgct ttcctggtga gcccatcccc ctatgagctt 8401 tgtgctgtgc cccgctagaa tggggtacct agtccccagc ctgctcccta gccagaggct 8461 ctaatgtaca ataaagcaat gtggtagttc caactcgggt cccctgctca cgccctcgtt 8521 gggatcatcc tcctcagggc aaccccaccc ctgcctcatt cctgcttacc ccaccgcctg 8581 gccgcatttg agacaggggt acgttgaggc tgagcagatg tcagttaccc ttgcccataa 8641 tcccatgtcc cccactgacc caactctgac tgcccagatt ggtgacaagg actacattgt 8701 cctggcatgt ggggaagggg ccagaatggg ctgactagag gtgtcagtca gccctggatg 8761 tggtggagag ggcaggactc agcctggagg cccatatttc aggcctaact cagcccaccc 8821 cacatcaggg acagcagtcc tgccagcacc atcacaacag tcacctccct tcatatatga 8881 caccccaaaa cggaagacaa atcatggcgt cagggagcta tatgccaggg ctacctacct 8941 cccagggctc agt //