LOCUS NG_008055 12238 bp DNA linear PRI 25-MAR-2012 DEFINITION Homo sapiens myelin protein zero (MPZ), RefSeqGene on chromosome 1. ACCESSION NG_008055 VERSION NG_008055.1 GI:190570180 KEYWORDS RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 12238) AUTHORS Luo,X., Sharma,D., Inouye,H., Lee,D., Avila,R.L., Salmona,M. and Kirschner,D.A. TITLE Cytoplasmic domain of human myelin protein zero likely folded as beta-structure in compact myelin JOURNAL Biophys. J. 92 (5), 1585-1597 (2007) PUBMED 17142269 REFERENCE 2 (bases 1 to 12238) AUTHORS Pham-Dinh,D., Fourbil,Y., Blanquet,F., Mattei,M.G., Roeckel,N., Latour,P., Chazot,G., Vandenberghe,A. and Dautigny,A. TITLE The major peripheral myelin protein zero gene: structure and localization in the cluster of Fc gamma receptor genes on human chromosome 1q21.3-q23 JOURNAL Hum. Mol. Genet. 2 (12), 2051-2054 (1993) PUBMED 7509228 REFERENCE 3 (bases 1 to 12238) AUTHORS Hayasaka,K., Himoro,M., Sato,W., Takada,G., Uyemura,K., Shimizu,N., Bird,T.D., Conneally,P.M. and Chance,P.F. TITLE Charcot-Marie-Tooth neuropathy type 1B is associated with mutations of the myelin P0 gene JOURNAL Nat. Genet. 5 (1), 31-34 (1993) PUBMED 7693129 REFERENCE 4 (bases 1 to 12238) AUTHORS Hayasaka,K., Himoro,M., Wang,Y., Takata,M., Minoshima,S., Shimizu,N., Miura,M., Uyemura,K. and Takada,G. TITLE Structure and chromosomal localization of the gene encoding the human myelin protein zero (MPZ) JOURNAL Genomics 17 (3), 755-758 (1993) PUBMED 7503936 REFERENCE 5 (bases 1 to 12238) AUTHORS Hayasaka,K., Nanao,K., Tahara,M., Sato,W., Takada,G., Miura,M. and Uyemura,K. TITLE Isolation and sequence determination of cDNA encoding the major structural protein of human peripheral myelin JOURNAL Biochem. Biophys. Res. Commun. 180 (2), 515-518 (1991) PUBMED 1719967 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Valerie Delague. The reference sequence was derived from AL592295.25. This sequence is a reference standard in the RefSeqGene project. Summary: This gene encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 and other polyneuropathies. [provided by RefSeq, Apr 2010]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-12238 AL592295.25 26403-38640 c FEATURES Location/Qualifiers source 1..12238 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="1" /map="1q23.3" gene complement(<1..597) /gene="SDHC" /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3" /note="succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa" /db_xref="GeneID:6391" /db_xref="HGNC:10682" /db_xref="MIM:602413" mRNA complement(<548..597) /gene="SDHC" /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3" /product="succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa, transcript variant 1" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_003001.3" /exception="annotated by transcript or proteomic data" /transcript_id="NM_003001.3" /db_xref="GI:78711818" /db_xref="GeneID:6391" /db_xref="HGNC:10682" /db_xref="MIM:602413" mRNA complement(<548..597) /gene="SDHC" /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3" /product="succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa, transcript variant 2" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_001035511.1" /exception="annotated by transcript or proteomic data" /transcript_id="NM_001035511.1" /db_xref="GI:78711819" /db_xref="GeneID:6391" /db_xref="HGNC:10682" /db_xref="MIM:602413" mRNA complement(<548..597) /gene="SDHC" /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3" /product="succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa, transcript variant 3" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_001035512.1" /exception="annotated by transcript or proteomic data" /transcript_id="NM_001035512.1" /db_xref="GI:78711821" /db_xref="GeneID:6391" /db_xref="HGNC:10682" /db_xref="MIM:602413" mRNA complement(<548..597) /gene="SDHC" /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3" /product="succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa, transcript variant 4" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_001035513.1" /exception="annotated by transcript or proteomic data" /transcript_id="NM_001035513.1" /db_xref="GI:78711823" /db_xref="GeneID:6391" /db_xref="HGNC:10682" /db_xref="MIM:602413" CDS complement(<548..567) /gene="SDHC" /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3" /inference="similar to AA sequence (same species):RefSeq:NP_002992.1" /exception="annotated by transcript or proteomic data" /note="isoform 1 precursor is encoded by transcript variant 1; succinate-ubiquinone oxidoreducatase cytochrome B large subunit; integral membrane protein CII-3; cytochrome B large subunit of complex II; succinate dehydrogenase cytochrome b560 subunit, mitochondrial; integral membrane protein CII-3b; QPs-1; succinate dehydrogenase complex subunit C; succinate-ubiquinone oxidoreductase cytochrome B large subunit" /codon_start=1 /product="succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 1 precursor" /protein_id="NP_002992.1" /db_xref="GI:4506863" /db_xref="CCDS:CCDS1230.1" /db_xref="GeneID:6391" /db_xref="HGNC:10682" /db_xref="MIM:602413" CDS complement(<548..567) /gene="SDHC" /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3" /inference="similar to AA sequence (same species):RefSeq:NP_001030588.1" /exception="annotated by transcript or proteomic data" /note="isoform 2 precursor is encoded by transcript variant 2; succinate-ubiquinone oxidoreducatase cytochrome B large subunit; integral membrane protein CII-3; cytochrome B large subunit of complex II; succinate dehydrogenase cytochrome b560 subunit, mitochondrial; integral membrane protein CII-3b; QPs-1; succinate dehydrogenase complex subunit C; succinate-ubiquinone oxidoreductase cytochrome B large subunit" /codon_start=1 /product="succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 2 precursor" /protein_id="NP_001030588.1" /db_xref="GI:78711820" /db_xref="CCDS:CCDS41431.1" /db_xref="GeneID:6391" /db_xref="HGNC:10682" /db_xref="MIM:602413" CDS complement(<548..567) /gene="SDHC" /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3" /inference="similar to AA sequence (same species):RefSeq:NP_001030589.1" /exception="annotated by transcript or proteomic data" /note="isoform 3 precursor is encoded by transcript variant 3; succinate-ubiquinone oxidoreducatase cytochrome B large subunit; integral membrane protein CII-3; cytochrome B large subunit of complex II; succinate dehydrogenase cytochrome b560 subunit, mitochondrial; integral membrane protein CII-3b; QPs-1; succinate dehydrogenase complex subunit C; succinate-ubiquinone oxidoreductase cytochrome B large subunit" /codon_start=1 /product="succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 3 precursor" /protein_id="NP_001030589.1" /db_xref="GI:78711822" /db_xref="CCDS:CCDS44263.1" /db_xref="GeneID:6391" /db_xref="HGNC:10682" /db_xref="MIM:602413" CDS complement(<548..567) /gene="SDHC" /gene_synonym="CYB560; CYBL; PGL3; QPS1; SDH3" /inference="similar to AA sequence (same species):RefSeq:NP_001030590.1" /exception="annotated by transcript or proteomic data" /note="isoform 4 precursor is encoded by transcript variant 4; succinate-ubiquinone oxidoreducatase cytochrome B large subunit; integral membrane protein CII-3; cytochrome B large subunit of complex II; succinate dehydrogenase cytochrome b560 subunit, mitochondrial; integral membrane protein CII-3b; QPs-1; succinate dehydrogenase complex subunit C; succinate-ubiquinone oxidoreductase cytochrome B large subunit" /codon_start=1 /product="succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 4 precursor" /protein_id="NP_001030590.1" /db_xref="GI:78711824" /db_xref="CCDS:CCDS41432.1" /db_xref="GeneID:6391" /db_xref="HGNC:10682" /db_xref="MIM:602413" STS 852..993 /standard_name="AL033654" /db_xref="UniSTS:93489" STS 4998..5170 /standard_name="GDB:567202" /db_xref="UniSTS:157711" gene 5001..10238 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /note="myelin protein zero" /db_xref="GeneID:4359" /db_xref="HGNC:7225" /db_xref="MIM:159440" mRNA join(5001..5134,7549..7715,8052..8265,8509..8644, 8805..8865,8996..10238) /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /product="myelin protein zero" /transcript_id="NM_000530.6" /db_xref="GI:295391070" /db_xref="GeneID:4359" /db_xref="HGNC:7225" /db_xref="MIM:159440" exon 5001..5134 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /inference="alignment:Splign:1.39.8" /number=1 CDS join(5068..5134,7549..7715,8052..8265,8509..8644, 8805..8865,8996..9097) /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /note="Charcot-Marie-Tooth neuropathy 1B; myelin protein P0; myelin peripheral protein" /codon_start=1 /product="myelin protein P0 precursor" /protein_id="NP_000521.2" /db_xref="GI:295391071" /db_xref="CCDS:CCDS1229.2" /db_xref="GeneID:4359" /db_xref="HGNC:7225" /db_xref="MIM:159440" STS 7488..7796 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /standard_name="GDB:567206" /db_xref="UniSTS:157712" exon 7549..7715 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /inference="alignment:Splign:1.39.8" /number=2 STS 7565..8077 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /standard_name="GDB:453314" /db_xref="UniSTS:157411" STS 7668..7841 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /standard_name="AL009353" /db_xref="UniSTS:81171" exon 8052..8265 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /inference="alignment:Splign:1.39.8" /number=3 STS 8057..9065 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /standard_name="GDB:453316" /db_xref="UniSTS:157412" STS 8412..8721 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /standard_name="GDB:567212" /db_xref="UniSTS:157713" exon 8509..8644 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /inference="alignment:Splign:1.39.8" /number=4 STS 8733..8979 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /standard_name="GDB:567216" /db_xref="UniSTS:157714" exon 8805..8865 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /inference="alignment:Splign:1.39.8" /number=5 STS 8959..9181 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /standard_name="GDB:567273" /db_xref="UniSTS:157716" exon 8996..10238 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /inference="alignment:Splign:1.39.8" /number=6 STS 9336..9584 /gene="MPZ" /gene_synonym="CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0" /standard_name="G15925" /db_xref="UniSTS:37164" STS 9405..10268 /standard_name="MPZ_930" /db_xref="UniSTS:462348" ORIGIN 1 agcagaggtc cgccctgggt gctaatgcta atcgccaccc cagtagggat ccaccctttg 61 ccagcagccc gctgggaacc cagacagcgc ccactcacgg tgggagcagc tagtgtctga 121 aggcattcga agcaaaggca aaatacacga agatctctct ctccgaagct aaatgtctaa 181 atacgctctc gaaatcgtag gacccatggg tggctgacct tgaagttatt ttctcagagc 241 tcggctctgg gtgcaggccc gagagcaatt tgcgttagaa gtactagagg aggtggggaa 301 aacagaaggg gcgagagccg agggcccctc gatacgaagt cagtgacccc gaagccctac 361 ggagcgcacc ggagcggctg ggggggacgg gaaaaggggt ctctaggatc cccgagcgct 421 tggcctccac acccatgggt cctttccctg cccaggcaca ggataaacag ttatcagcaa 481 aacgtgaggg gccagttcag atctccggag ggccgcaggc accaactccc agtcccactg 541 aagtcacctc agcaacagcg cagccatctt gggttccggt ctggacggaa gtgacgccag 601 gcggccccgc cacccgaggg cggaggcgcg ccggctgggg gtcggggttg ggggtgtcat 661 gtgacgagag tctctttaaa aggctctgga gcttctccgc tcagctctgc ctagctggtt 721 tgctggttgt tttctggttt tttagtctcc tcctccgcct cctgcagccg acttctaccg 781 gaatttgcca ggatttcggc agaaacgccg ctggctcaaa atctgcagtc tacgttccac 841 ctgcgtacat attcattttg tatcgcactc ccaaacagca aacggcggac ttgtttagat 901 tcttccttaa ggacttcgca gtctgttgcg ttccccctgc ctcccaggtc ggcctaaaaa 961 cgtggtggtt ggccggttga gaccccgaag agaaaagata ctttgggttc cctccctttc 1021 taatacgaag ctttaaccag acagatacat aaattgtgac ctaagttggg gagtgtgtag 1081 aggggcctcg agaagacctt gcggaccacc attcccgaaa acgaggagcc tcatctaacc 1141 acctcgatta gaccccacaa ttcctgggtt tgagctgcca catggaccag gcgcccacta 1201 gccgaggaca atgctccctt gttcgttgtt tcagcgctat gtgggtgaca cccacagcta 1261 gaagaacccg gagtgagggg aagaacacgc tttgatttat atatgtgtat atatatatat 1321 acagttttag ggaacccaag cacaggaatc aactgccgag cactcaagac tgaagaaaga 1381 agaagagcaa atgataaagg aagggaacag agcacaaaag ttcttgactc ttgtggggag 1441 tagggtggag aggagtaaaa gggacaggct agagcaactc ctatttctac aaaaaaaata 1501 ctcaattata ttaatattca gatcttatgt atatttagca tccctgcact tcaggattta 1561 aatagcacaa attcacttat ttctgcatca gatgaataat actactttgc atttctataa 1621 tgcttgacaa agcacattcg tacactttag gattgaaaga ggctctctaa tccaatctac 1681 tatctatgca gggatctcct ctgcaacacc cataacagct gatcttcaag actctacccc 1741 cccatattca atgatgggta cctcaaacaa caagttttat ttaatgaaca acttattcgt 1801 tagttattat atttaaatac agttttgtgc tatcgaaatt ccagtcattg acttggctct 1861 ctggagcttc acgttaacaa acccaaggaa tgcctttttc actcagatct tttttggttt 1921 ttctttttct ttttcttttt cttttatttt gagacgtagt ctcactctgt cgcccaggtt 1981 ggagtgcagt ggcgctatct cagctcactg cagcctctgc ctcccaggtt caagcgattc 2041 tcctgcctca gcctcccccc aagtagctgg gattacaggc ctgcaccacc atgcccggct 2101 aattttctgt atttttagta gagatggaat ttcaccatgt tggctaggct ggtctagaac 2161 tcctgacctc aagtgatcca ccggcctcgg cctcccaaag tcctgggatt ataggtgcga 2221 gctaccactc ccagcccact cagctcttta aatattaata atttcattta gcatgtagtt 2281 atggactttt tgtcagtccg tgaaaagttc tgtaggggat tcaaagatac agatgtttgt 2341 actgtcccca agaaggttat agccttagca ggatcaataa agacatgcaa caaagaaagt 2401 agcaacaacc cattgaagag ggtgttgata aaaggggtgg ttagataaag aggaaatgat 2461 tgcttacagt tgggaggtgg agttaggtgg aaattttgga ggggagagtt ttgggggttt 2521 tttttttttt gtactttgaa ttgctgtttt atagaaatgt tgactacaac atcctgtaaa 2581 catttgtcaa tgatgatggt tttgcctatg gacttcataa gcaatcccat atttagaatt 2641 ccacaaccca aatctaatac taatgaccat acccaccagg gctgtggtct aatgagatgc 2701 caggaaggta ccaggacact gtccttcacc tgggtgagcc tgcagtggtc tcatagcagg 2761 aataacaatg accaccccac ttacattaac ttctagaggt caggcacggt gactcacacc 2821 tgtaatccca gtacttaggg aagccaaggc agaaggatca cttgagtata ggagttcaag 2881 atcaacctga gcaacacagt gagatcctca tctctacaaa aaattgaaaa attagctggg 2941 tatggtggtg gctgcctgtg gctcagctaa tctggaggct gaagtgggag gatcgcttga 3001 gcctgggagg ttgaggctgc agtgagctat cattgcacca ctgcactaca gcctgggcca 3061 cagagcaaga ccttatctct gaaaaaaaaa aaaaaaaaat tttaaactag cccagcatgc 3121 tggcatgcgc ctgtagttcc cagctacttg gaaagctgag gtaggacaat tgcttgagcc 3181 tcagaggtca aggctgcagt gagccatgat catgccactg cattccagcc tgggcaacag 3241 agcgagactg cctcaacaaa caaaaaaacc tcagctctgg ttatgtagac atccccatgg 3301 ctaactccac cccaacacct tcaggttctc atgatgtacc aaattgaatt caccttcttt 3361 cacctgtcat ttaaggcctt tcacaaactg gtttcgactt tcctgtccag tctcatttct 3421 gactatgcca cttcaagttt ccccaaatca agtcaaagtg gatggcacaa gatcggccct 3481 gaatatatcc aacacttcag aaacctacat ctcatataca tacacacaca cacacacaca 3541 cacacacaca cacacacaca cacacacaca cacattctgt ctctccgtct cacctctttg 3601 tccttgcttt tgctgttcta tcttctggta accctcccta tctccctttc caaaatgaca 3661 gtcatccttc aaggctgatt catatctaac attgcctcct agacacaact attcttccct 3721 ctgaactatt tatttgtttg attatttatt tatttattta tttttgagac agagtttcat 3781 tctgtagccc agggtggaaa gcagtggcac aatcatagct cgctgcagcc ttgatttccc 3841 aggttcaagc gatcttcctg cctcagcctc ccaagtagct gggactacaa gcatgtgata 3901 acatgcccag ctgatttttt aaaaaatttt ggtagaggcg aggtcttgct atgttgccca 3961 gacaggtctc aaactcctaa actcaagcaa tcctcctgca taagcctacc aaagtgctga 4021 gattacaggt gtcagccact atgcctggca taaacttcat ttattaaagt ttattttgtc 4081 tttaatctct catataactt agtcttcctg atattgcagc tgtgtgtgcc cctcttttgt 4141 actcccagca ttttgttcat tactaaagga agtgtcatgg cttattatac ttgattgttg 4201 atgggtttgt cctctgatct tcccatctcc acctccccaa accaaatttt caactccttg 4261 ctggaaggac ttaattttta ttcctctctc tattacctgc attctcatac tttacatatt 4321 gctggcactt aatacaattt tgtagccttg aaataaattg aaatggactt aaacagcagc 4381 atgaagcact gaaggacttc ttgacaaacg gaaaggtcag gggcttcttg cctggaaata 4441 gtccagtgga gaaaaacttc tgtctgggaa gaatcgcaca ggatgaaggg aggtgcgggg 4501 aaaaaaactc ccataggact tggtcatctc aagaagtctg taatgcagcc cacattagag 4561 gagataacag gggatatcct attttcagag ttctctgggg gaaacctccc tctagttcct 4621 agggctgtga ggcagcctct ctcaggcaag gaggctgagg agaaatccct ttttatggcc 4681 tttaaattga ggttccatat ctatccctca gagaagtgtg tctgtgtccc tgtttttgtc 4741 cctctccctc accacccccc acaacattcc agcctggggc agggggaggc cagtggacac 4801 aaagccctct gtgtatgggg tggtatgtgt ccccccaccc ctccacccag actatacaat 4861 gccccttctg ctccctgcac tctgcccccc tccccaccac ctctcaactg cacatgccag 4921 gctgcaattg gttactggct gaggacagcc ccctcatgct ggggccctag gggattttaa 4981 gcaggttcca ggaacccccc gttcagttcc tggtccccca ctttctcaac cccacagatg 5041 ctccgggccc ctgcccctgc cccagctatg gctcctgggg ctccctcatc cagccccagc 5101 cctatcctgg ctgtgctgct cttctcttct ttgggtaagt ggagccactc tactctggga 5161 gtcttgggac tcaggtgtct ctcagcaatc cccacagcct ttgctgcact ccccactgca 5221 accaaagaaa gaacaagcag gagcaggaag gtgacattat attcagaaag aaaaaatatg 5281 cggctgggca tggtggctca tgcctgtaat cccagcactt tgggaggcca aggtgggata 5341 attatttgag ccccaggagt tggagaccag cctggacaac ataaccagac tccatctgta 5401 aaattcaaaa aaaaaaaaaa tatatatata tatatatgaa aagaaaaaaa tatgcattta 5461 gagggaggaa gtagaggttt tattttaaaa gaaagggtaa aagagagtgt agcaagcttc 5521 cctgagtggt ggccatggct ggacccaggt tggaaatagt agcatgcccc cagagccatg 5581 ctaacagcct ggtgggaagc agtgttagat tacataaaga aataggctca aacacctggg 5641 tttggttccc actcgtcccc tagcagtgca ggaggtgcct taaccttagt ttcccagaag 5701 gaaaaagaga gtgcgatcta agtaaggagc ccaggtttgt ggtctcagct cctcagattt 5761 tttgtctctc tatggctcct cacctgttgt gtgggtgaat ggagtgaggt tctatgagat 5821 tctgggatct tatccctcta aagctgtctt ccttcataag ctgaccagcc ctttccttgc 5881 cccctggcag atgttgggtg agtaagaggt caaagcagga ttattggaat ggccccttcc 5941 cttctctgaa ctgccctgaa tcctagtgca atgagtgagc cataggcaag tgggggtggt 6001 ggggaggaca tcaagggaaa gggggctggc cagaatgccc agggttctct gctgtcagct 6061 gcttgagccc tagactcttc tgggttgtac tgggctattt gggggtaccc tgagaaaatg 6121 ttaaagatag agagttggag aagggcatag tgagggaaat agggggaagg aatcttgatg 6181 tataaggaag agggagagtt gtgtctcaac acttgttcca ctcatagaac cattgagcac 6241 agctgagaag ggcaatggtt gatattgtaa caggaggaat agaagttaga gccagtgaat 6301 tatctccctt gttaaacaag ggggattccc aagaaggttc taaggtggaa gttccagaag 6361 gtaagtacat ggtattgcat gctgaggtga gagattcagg acagttgggg tgggagtagg 6421 ggtggcatga gccccccagc gttggtcaga caatggaact ttgtttggtt gccacctccc 6481 cctcctgtag aacaaaaagg tctacagttg cccctccctg gggccagccc acacacatag 6541 tctctctgga atgaccttcc ttgtgtgggt aagtcttggg gatggcactg ggccacagtg 6601 gccaagagga aggtgaggac agttgaacca tagagggctc acatgtaggg tcatctgagc 6661 tgtaggcttg gggtgttgct ctgcacccag ctgagagggg tatgaggccc ttcccttcct 6721 gactctccag tcaagagcaa gctgtatggc aaccagggat tcagcaatga ggacagttgt 6781 gccagggaag aagacttata ttttctagtt atcttcattt ttttctgcaa gaaatctgag 6841 tttgctgtat tgtgaaatcc aatgcagctg ttaaaataag attgatatct atgaatcaac 6901 agggaaagct cctccagata cgtaagttct taagcaaaaa gacactagaa tacaatgcaa 6961 tatgtatgtg gaaaaaaaaa ctccacaaaa ctatttgttg taagtatgtg tatatcttga 7021 gtttattgag tttatactga gtttgattca tattaaatgg ataacttgtt acatcttgga 7081 agggaataca ggaaaggaat ttgttgggct aagtgtcaaa ggagactttt gttttatttc 7141 tattgcttga atagtttata agaagagtac aatatgtatt acctgtataa tttataataa 7201 attttaaaaa tttagaacac tgcatctaaa ggatagctta aaagttagat actgacccaa 7261 aggagaagtg agacttaaag acagaaccca atctctggaa gtcctcaaga gaattctgtt 7321 actgctgatt tcatcttctc tacagacatg ctaaagagct tgacagacac agcatttatg 7381 ctcatctgtt cagttagtcc ccagagactt ggggctcaga atttgttgtt tcttttccaa 7441 attggcctct gacctgtgac tcagcacttg atttcctact gatctcactt cctctgtatc 7501 ccttactggg cccataggtg catctgattc cccactttgt gcttgcagtg ctgtccccgg 7561 cccaggccat cgtggtttac accgacaggg aggtccatgg tgctgtgggc tcccgggtga 7621 ccctgcactg ctccttctgg tccagtgagt gggtctcaga tgacatctcc ttcacctggc 7681 gctaccagcc cgaagggggc agagatgcca tttcggtgag tgcctggggg aatcctgggg 7741 ttggataaca gaaagtgctt caaagaacaa caaaaaagat aacttgggct aaggaggggg 7801 aaatcctttt tgagccataa ccccaacttt ggcaaggtaa atgacagtct ttgtcaccct 7861 gactacattg tcctcccttc tccagcacta ccctttccag cccaagatcc cttaccctga 7921 ggctggagcg aagctttttt tttttttttt ttttttttgc ttttttcttt ctgtaacaaa 7981 ttatggagct aagctttgac agctgtgttc tcattagggt cctctcacat gcttcccctc 8041 attcctcata gatcttccac tatgccaagg gacaacccta cattgacgag gtggggacct 8101 tcaaagagcg catccagtgg gtaggggacc ctcgctggaa ggatggctcc attgtcatac 8161 acaacctaga ctacagtgac aatggcacgt tcacttgtga cgtcaaaaac cctccagaca 8221 tagtgggcaa gacctctcag gtcacgctgt atgtctttga aaaaggtgtg agaagggatg 8281 gggacaaggg tatgggaagc agtttgggag gggatcaggg aggactgata ggttggggga 8341 agaggcaaaa agcccggcct aaggaccttt attcaggctc tgggagcgtg ggcagaaggc 8401 agttttagct gggagtccta catcctcaat gcagggcata cactcggact aggaaccaca 8461 gatacagggc cctgctcatt ctcccacttc ttttcccacc cctcctagtg ccaactaggt 8521 acggggtcgt tctgggagct gtgatcgggg gtgtcctcgg ggtggtgctg ttgctgctgc 8581 tgcttttcta cgtggttcgg tactgctggc tacgcaggca ggcggccctg cagaggaggc 8641 tcaggtaagg ggcggagcct agctcccctc cccctctccc cactatcccc catctgggcg 8701 gagactactc cagtgggtgg gagggccaag gggaagagga agctgtgtcc gcggtgcaag 8761 gggttccggc gaggccaaac gtacagcagt ctctcttctt gcagtgctat ggagaagggg 8821 aaattgcaca agccaggaaa ggacgcgtcg aagcgcgggc ggcaggttag cgggacttgg 8881 ggcctagaca agatgggaag gagaaccctg ggagccgccg ggcagcagtg aggggtggga 8941 tgggaacagt caagccccag tcgctcggtg actgatgtgt gcgcccctcc cccagacgcc 9001 agtgctgtat gcaatgctgg accacagcag aagcaccaaa gctgtcagtg agaagaaggc 9061 caaggggctg ggggagtctc gcaaggataa gaaatagcgg ttagcgggcc gggcggggga 9121 tcgggggtta ggggtggagt ccgccaaagg cccaaaggtg atggtcatcg agatggagct 9181 acgaaaggat gagcagagcc cggagctccg gcctgctgtc aagtccccca gcagaaccag 9241 cctcaaaaac gccctcaaga acatgatggg cctgaactcg gacaagtgat cgccaccccc 9301 ccaccccagg ccctgccaga gcagggggac ctaggctcct cttacccccg tctaggtgct 9361 ttccctcttt gctcccccgc cctgccctgc cctcacctcc ctttgagatg taagtttcat 9421 tccagaattc attccccagg caattgtatt ctcccccacc ttcacccctg gctttctggg 9481 agcccaggag ctaatcctac ccctcacctg ccccgggggc tgtgtgtttg gtgcctgtcc 9541 acctgagcac tgagaagaaa gggactttga taccctctgc ctcaagtcca ggccacctgg 9601 cattcccatc tcctgcatcc cccagcctgt ccccctggct gtttcctctc ccgtccctcc 9661 ctcccctcta ccaggtggcc cagctccata ctctgtcccc ccagctaata cccagagcac 9721 ccagatcaga ctctccttca gggtttattt aggttattat tttttatttt ttaatccatt 9781 ctttgtttgt ttacctgtgc tcatcctctg cccttacacc catgactgag gaccaatgac 9841 gtcatgtggc ttttgcaatt cacgcccccc ttaagtcctt aatgaagagc cagcccaagt 9901 agaggggccc ctgatcctca cacttcagta tagcattggt tccccctgac cactttggag 9961 cactgttctg ggactccagg tcttgaggag agagacagag agagagaatg gatcctcata 10021 ggtcagggag tgggggaggg ggcaaatgag ccttaagaaa tggtttttaa acaaccaaac 10081 aaaaagcagg aaaaacaaat gggaaatggg ggggcggggg ggaggaagag gctgcactgc 10141 agccacaggg gattcttagg atttttctac attctgtata tttcttctca aacctccaaa 10201 tgtccttaaa tgtttaataa acactgacat ttccagaagc tgctgccttg tctagaattt 10261 cctagtcctc ctgggaataa ttcctgcccc ttatcccatc cccaaccttc catacttggc 10321 ttcagttgtt tagtttgttt ttttggggtg ggcttatata gtatactaga aagaactctg 10381 aaatagcctc acaagacaca ttcatacctt cagcaaataa tcagtgagat tatactacgt 10441 tgtaaactct gccagtctct gcttttacat gagttaaaac gcagaatctg tcttcaccaa 10501 gatctgaatt ttaaaacatc ccagccactc tctagctgtg tgatccccag gacagttacc 10561 tgactttggt aagcttgttt atgtacttgt aaacaactga gataatgata tctgccctgc 10621 ttaattccta gggattttat aataatcaaa tgagatcctg tgtatggaaa actttgtaaa 10681 ctgtaagttg atatacaact aaatattaag gtgttcaata tttgtttcta gtgcttgcct 10741 aaggtagtac actttacaaa ttagcacaaa tcccattcac ctctctaaac aatcactgct 10801 ttgttttgtt ggtacatgat tttacttctg tttacctatt aataggtata ctattaatac 10861 ctcattagct agtttgttgg tatgttgatt taggtatacc attaatatcc tggtatcctg 10921 aactgattgt ggaaaaacat atacgtatca ttttcccctg gggattactg atggcacaaa 10981 aaaacccaaa gtgcccacaa gtaatttctt ccccttgtta agaagctaaa gatatgatta 11041 acaccagctt taccaaaacc cagagtgctt ccatttgttt gaggggtgtc ttcaatgtct 11101 tttaaaaaaa atcaatctgc cttcatttaa atataaaagc taatagagta tatatagcct 11161 tttgttgggg ggaagtggga gaggaaactt agtcacaacc cagtaataaa gttgggaata 11221 tcttaagccc aagattcctt attagttaag atgctaaact gtccattatt cattagatag 11281 ttgcagctgg gttccctgct taaacttccc agactgtcag gagagtcaaa tgaggttgga 11341 tgtggtggct catgcctgta atgccagcac tttgggaggc cgaggtgggc agatcacttc 11401 aggctaggag gttgaggcca gcctgaccaa catggctaaa cactgtctcc actaaaaata 11461 caaaaattag ccgagcatgg tggtgaacgc cttctaaccc tggctacttg ggcagctggg 11521 gcacgagaat tgcttgaacc gcggaggcgg aggttgcagt gagccgagat catgccgctg 11581 cactctagcc tgggcaacac agcgagacta tgtctcataa aaataaaaaa gaaagagaga 11641 gagagagagt caaatgaaat attatgctac ttatgagata gagtatagct caaagcttct 11701 catttaatta cacttttgtt ctaaaattta tcagccacct gcattttgct agctcagttt 11761 atccaattat tttaatattt cttattccat caagaatcct ggtaccctgg gacaacattt 11821 tgcaatctct tgcattaggc attttcacaa gcattgcaca cttaatgtgg gtttttccag 11881 gactgtgccc attttccaca atccccaaca aagtaagcca catcccccct ttctttcctc 11941 tgcagtaaag cattaaataa agtctagaat aatgattcag ataaagggaa atgacattgt 12001 tatatgggaa actttgaatc ccatctaatt attactttga aataaatcgt tcacaatcct 12061 cagtgcgttg ttaataatag caataatttt gcccaggcat gtgagcactt tgagaataat 12121 ttaaagcctt tttcagtgtt aaccataaaa agaaaaagat tataacccaa tttatgaata 12181 cgcagacaaa gagtctaaat aaaatatttg caaaagagaa ttccacaatg agttaata //