LOCUS NG_033731 9499 bp DNA linear PRI 23-JUL-2013 DEFINITION Homo sapiens GDP-mannose pyrophosphorylase B (GMPPB), RefSeqGene on chromosome 3. ACCESSION NG_033731 VERSION NG_033731.1 GI:526120199 KEYWORDS RefSeq; RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC099668.2. This sequence is a reference standard in the RefSeqGene project. Summary: This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-6368 AC099668.2 7299-13666 6369-6369 "G" 1-1 6370-9499 AC099668.2 13668-16797 FEATURES Location/Qualifiers source 1..9499 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="3" /map="3p21.31" gene <1..4680 /gene="IP6K1" /gene_synonym="IHPK1; PiUS" /note="inositol hexakisphosphate kinase 1" /db_xref="GeneID:9807" /db_xref="HGNC:18360" /db_xref="MIM:606991" mRNA join(<697..872,1320..4680) /gene="IP6K1" /gene_synonym="IHPK1; PiUS" /product="inositol hexakisphosphate kinase 1, transcript variant 1" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_153273.3" /exception="annotated by transcript or proteomic data" /transcript_id="NM_153273.3" /db_xref="GI:58530860" /db_xref="GeneID:9807" /db_xref="HGNC:18360" /db_xref="MIM:606991" mRNA join(<697..872,1320..4680) /gene="IP6K1" /gene_synonym="IHPK1; PiUS" /product="inositol hexakisphosphate kinase 1, transcript variant 2" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_001006115.2" /exception="annotated by transcript or proteomic data" /transcript_id="NM_001006115.2" /db_xref="GI:58530861" /db_xref="GeneID:9807" /db_xref="HGNC:18360" /db_xref="MIM:606991" mRNA join(<697..872,1320..4680) /gene="IP6K1" /gene_synonym="IHPK1; PiUS" /product="inositol hexakisphosphate kinase 1, transcript variant 3" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_001242829.1" /exception="annotated by transcript or proteomic data" /transcript_id="NM_001242829.1" /db_xref="GI:338827647" /db_xref="GeneID:9807" /db_xref="HGNC:18360" /db_xref="MIM:606991" CDS join(<697..872,1320..1853) /gene="IP6K1" /gene_synonym="IHPK1; PiUS" /EC_number="2.7.4.21" /inference="similar to AA sequence (same species):RefSeq:NP_695005.1" /exception="annotated by transcript or proteomic data" /note="isoform 1 is encoded by transcript variant 1; inositol hexaphosphate kinase 1; Pi uptake stimulator; insP6 kinase 1; ATP:1D-myo-inositol-hexakisphosphate phosphotransferase" /codon_start=3 /product="inositol hexakisphosphate kinase 1 isoform 1" /protein_id="NP_695005.1" /db_xref="GI:23510335" /db_xref="CCDS:CCDS33760.1" /db_xref="GeneID:9807" /db_xref="HGNC:18360" /db_xref="MIM:606991" /translation="MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDD HTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETV EQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHS EVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFK YPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCR NKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSS LLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPK VDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ" CDS join(<697..872,1320..1853) /gene="IP6K1" /gene_synonym="IHPK1; PiUS" /EC_number="2.7.4.21" /inference="similar to AA sequence (same species):RefSeq:NP_001229758.1" /exception="annotated by transcript or proteomic data" /note="isoform 1 is encoded by transcript variant 3; inositol hexaphosphate kinase 1; Pi uptake stimulator; insP6 kinase 1; ATP:1D-myo-inositol-hexakisphosphate phosphotransferase" /codon_start=3 /product="inositol hexakisphosphate kinase 1 isoform 1" /protein_id="NP_001229758.1" /db_xref="GI:338827648" /db_xref="CCDS:CCDS33760.1" /db_xref="GeneID:9807" /db_xref="HGNC:18360" /db_xref="MIM:606991" /translation="MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDD HTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETV EQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHS EVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFK YPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCR NKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSS LLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPK VDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ" CDS join(<697..872,1320..1853) /gene="IP6K1" /gene_synonym="IHPK1; PiUS" /EC_number="2.7.4.21" /inference="similar to AA sequence (same species):RefSeq:NP_001006115.1" /exception="annotated by transcript or proteomic data" /note="isoform 2 is encoded by transcript variant 2; inositol hexaphosphate kinase 1; Pi uptake stimulator; insP6 kinase 1; ATP:1D-myo-inositol-hexakisphosphate phosphotransferase" /codon_start=3 /product="inositol hexakisphosphate kinase 1 isoform 2" /protein_id="NP_001006115.1" /db_xref="GI:55769518" /db_xref="CCDS:CCDS43092.1" /db_xref="GeneID:9807" /db_xref="HGNC:18360" /db_xref="MIM:606991" /translation="MLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLL LENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQ LDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQ ASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSP EAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ " gene 5001..7499 /gene="GMPPB" /note="GDP-mannose pyrophosphorylase B" /db_xref="GeneID:29925" /db_xref="HGNC:22932" /db_xref="MIM:615320" mRNA join(5001..5377,5503..5583,5673..5721,5861..6003, 6221..6379,6465..6543,6617..6744,6828..7499) /gene="GMPPB" /product="GDP-mannose pyrophosphorylase B, transcript variant 1" /transcript_id="NM_013334.3" /db_xref="GI:523567527" /db_xref="GeneID:29925" /db_xref="HGNC:22932" /db_xref="MIM:615320" exon 5001..5377 /gene="GMPPB" /inference="alignment:Splign:1.39.8" /number=1 CDS join(5249..5377,5503..5583,5673..5721,5861..6003, 6221..6379,6465..6543,6617..6744,6828..7223) /gene="GMPPB" /EC_number="2.7.7.13" /inference="similar to AA sequence (same species):RefSeq:NP_037466.2" /exception="annotated by transcript or proteomic data" /note="isoform 1 is encoded by transcript variant 1; mannose-1-phosphate guanyltransferase beta; GTP-mannose-1-phosphate guanylyltransferase beta" /codon_start=1 /product="mannose-1-phosphate guanyltransferase beta isoform 1" /protein_id="NP_037466.2" /db_xref="GI:11761619" /db_xref="CCDS:CCDS2802.1" /db_xref="GeneID:29925" /db_xref="HGNC:22932" /db_xref="MIM:615320" /translation="MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAA GVDHVILAVSYMSQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETAD PFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFV EKPQVFVSNKINAGMYILSPAVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMD IGQPKDFLTGMCLFLQSLRQKQPERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGP GVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVSLWAGLGGERGGECAC LPDKAYPLLEVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM" exon 5503..5583 /gene="GMPPB" /inference="alignment:Splign:1.39.8" /number=2 exon 5673..5721 /gene="GMPPB" /inference="alignment:Splign:1.39.8" /number=3 exon 5861..6003 /gene="GMPPB" /inference="alignment:Splign:1.39.8" /number=4 exon 6221..6379 /gene="GMPPB" /inference="alignment:Splign:1.39.8" /number=5 misc_difference 6369 /gene="GMPPB" /note="This sequence differs from the reference genome assembly (NCBI Build 37) at this position. A was replaced by G to represent the standard allele identified by alignment of public cDNAs." /replace="a" exon 6465..6543 /gene="GMPPB" /inference="alignment:Splign:1.39.8" /number=6 exon 6617..6744 /gene="GMPPB" /inference="alignment:Splign:1.39.8" /number=7 exon 6828..7499 /gene="GMPPB" /inference="alignment:Splign:1.39.8" /number=8 gene complement(7446..>9499) /gene="RNF123" /gene_synonym="FP1477; KPC1" /note="ring finger protein 123" /db_xref="GeneID:63891" /db_xref="HGNC:21148" /db_xref="MIM:614472" mRNA complement(join(7446..7790,7870..7955,8081..8175, 8322..>8464)) /gene="RNF123" /gene_synonym="FP1477; KPC1" /product="ring finger protein 123" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_022064.3" /exception="annotated by transcript or proteomic data" /transcript_id="NM_022064.3" /db_xref="GI:375298724" /db_xref="GeneID:63891" /db_xref="HGNC:21148" /db_xref="MIM:614472" CDS complement(join(7670..7790,7870..7955,8081..8175, 8322..>8464)) /gene="RNF123" /gene_synonym="FP1477; KPC1" /inference="similar to AA sequence (same species):RefSeq:NP_071347.2" /exception="annotated by transcript or proteomic data" /note="kip1 ubiquitination-promoting complex protein 1" /codon_start=2 /product="E3 ubiquitin-protein ligase RNF123" /protein_id="NP_071347.2" /db_xref="GI:37588869" /db_xref="CCDS:CCDS33758.1" /db_xref="GeneID:63891" /db_xref="HGNC:21148" /db_xref="MIM:614472" /translation="MASKGAGMSFSRKSYRLTSDAEKSRVTGIVQEKLLNDYLNRIFS SSEHAPPAATSRKPLNFQNLPEHLDQLLQVDNEEEESQGQVEGRLGPSTVVLDHTGGF EGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQ EEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSL GTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYRPLQDPPSADLVRAQ RLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHFAPLLRKVYLV EAVLMSFLLGIVEKGTPTQAQSVVHQVLDLLWLFMEDYEVQDCLKQLMMSLLRLYRFS PIVPDLGLQIHYLRLTIAILRHEKSRKFLLSNVLFDVLRSVVFFYIKSPLRVEEAGLQ ELIPTTWWPHCSSREGKESTEMKEETAEERLRRRAYERGCQRLRKRIEVVEELQVQIL KLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNMPMLCPPEYMVCFLHRLISALR YYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKA NIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALAVGGPLPLPRPGWLSSPTLGRAN RFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDIEGSHWNEGLLLGRPPEEPEQ PLTENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRK DILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDRTG SLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADARIV GTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVR LWRGCGFGYRYTRLPHLLKTKLEDANLPSLQKPCPSTLLQQHMADLLQQGPDVAPSFL NSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMT ITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHY PILVAVTGILVQLLVRGPASEREQATSVLLADPCFQLRSICYLLGQPEPPAPGTALPA PDRKRFSLQSYADYISADELAQVEQMLAHLTSASAQAAAASLPTSEEDLCPICYAHPI SAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVEDWEKGANTSTTSSAA" gene 9170..>9499 /gene="AMIGO3" /gene_synonym="AMIGO-3" /note="adhesion molecule with Ig-like domain 3" /db_xref="GeneID:386724" /db_xref="HGNC:24075" mRNA 9170..>9499 /gene="AMIGO3" /gene_synonym="AMIGO-3" /product="adhesion molecule with Ig-like domain 3" /transcript_id="NM_198722.2" /db_xref="GI:224809459" /db_xref="GeneID:386724" /db_xref="HGNC:24075" ORIGIN 1 ctaaaaaaaa aaaaaaaatt aggcatgcct gtagtcctag ttgttccaga ggctgagggt 61 gagaggatct cttttcattt tgggaagatg aaaaagttct agctgggcgt ggtggctcac 121 acctgtaatc ccagcacttt gggaggctga ggcaggcgaa tcacaaggtc aggagttcga 181 gaccagcctg gccaacatgg tgaatccctg tctctactaa aaatacaaaa aatgagccgg 241 gtgtagtggc gggcacctgt aatctcagct actcaggcag ccgaggcagg agaatagctt 301 gaacctggga tgcagaggtt gcagttagcc gagatcactc cagggcactc cagcctgggt 361 aacagagcga gactccgttt caaaaaaaaa gaaaagttct agagatagat ggttgtgagt 421 agagatagat ggttgtgatg gttatacaac aaagtaaatg tacttcatgc cactgaattg 481 tacacttaaa aatggctgaa gtaaatttta tgtatatttt accacagttt ttattggtta 541 agtaataagc cagtggtgtg aaacccatat ttgagagttt gagacaagta catactgcat 601 taggtaaaag ccccctttta tagaaaaact gggttgtgct ttcctggctg gggctgatgg 661 tgagtgtggt tgtcattctc cttgaccgtg gcccagagtt cctcctgctt gagaacgtgg 721 tgcaccactt caagtacccc tgcgtgttgg acctgaagat gggcacgcgg cagcatggcg 781 atgacgcgtc agctgagaag gcagcccggc agatgcggaa atgcgagcag agcacatcag 841 ccacgctggg cgtcagggtc tgcggcatgc aggtgagtta cctctgctca gagcctaggt 901 gctgccactt gcatgatttg ggttgtgctc atacctgcct gccatctatg ccaagtgtgt 961 cctcctgagc ccctctgtcc ttacctgttg actttgatat gggcctcagg tgcaggacca 1021 ctgtgagagt ctgctgcctc gacattggga caaataagac tcttgcctgt caacaagatg 1081 ttccgatgtt ggaggagggc tccaaagctg ggggcaggga acccataggc ctggtattgc 1141 tttctcttgg ttctgcaatg ggaaaaccca gggtgaatgt ggcctgcctg gttccactta 1201 gataggtgag cagaaaagct caggttggtc aaagtccctt ccagacagtg tttgcccagg 1261 gcactgtgag ctcttcagac ttccctggca ctcaccctgt ctgcctcctg gggtttcagg 1321 tgtaccagct ggacacaggg cattacctct gcaggaacaa gtactatggc cgtgggctct 1381 ccattgaagg cttccgcaat gccctctatc aatatctgca caatggcctg gacctgcgac 1441 gtgacctgtt tgagcctatc ctgagcaaac tgcggggcct gaaagctgtg ctggagcggc 1501 aggcctctta ccgcttctac tccagttccc tgcttgtcat ctatgatggc aaggagtgcc 1561 gggctgagtc ctgcctggac cgccggtctg agatgcgtct caagcacctg gacatggtgc 1621 tccctgaggt ggcgtcatcc tgtggcccca gcaccagccc cagcaacacc agccccgagg 1681 cgggtccctc ctctcagccc aaggtggatg tccgcatgat tgactttgca cacagcacat 1741 tcaagggctt ccgggatgac cccaccgtgc atgatgggcc agacagaggc tacgtgtttg 1801 gcctggagaa cctcatcagc atcatggaac agatgcggga cgagaaccag taggccctgt 1861 tctgggcccc cagaacccct tcctctccac tgcaggcagg gaccattgtt ctgaacttgc 1921 cgtgaggaca cacagacttg cttttaaagg gttatatttc tctttggtgt aaactaaaag 1981 aaatgttttt agctgtagcc tggaatccat atatataaag tgaaggaggg cagaccacac 2041 gccctctcag ccaggctcct cagctttgtg gctctgactg gtgtgtccag gctgccttag 2101 gaaggaagag gtgcccctgg tgggcttggc agcagggaca gggtgccctt ggacattggt 2161 ttctcttgtc tagatctttg agatctgtgg ctgcagggcc ctgctgattg taaggtaaag 2221 ccctgggctg gtgcagggcc cctccacgcc cactcttccc ttgttcccca gaagtagagg 2281 gctctgggtg cccatttctt gggggctttc cagtcttatg ctgtgggtgt cagctagctc 2341 tttaataggt gccctcaggg caccacaggg ctgactgcac aaagctggac ccatccttcg 2401 gtctgacctt agcatggggc tagattaatg aagctgggct gaggccaact tatggcagag 2461 ggcggcgcct gggttcccca ggcacctgtt ggcacgtgac aggttggcac ctgtcctatt 2521 cctgaaacag cctctctcac caagttccct tgcctaagaa ggccactccc tcccacccca 2581 ctgaagtggg ggatagtcgg tgtcctagca ggcctcaggg cctctggtgg ctctggccca 2641 gacagtattt gcagttcttg tgctatgggt gggagtcttc ttcctcaagt ttcggcagct 2701 gtgctgctgc tggatgggct gctcctccca gggctcaagg gctgtggtcc gctcagggtc 2761 tcatttcccc aggccaagtt caaggcagca gccctttgtg aggcgctctt ggccctgggc 2821 ctggagggag aactttaagc ttttttgctc acagggacgt ggtatgggcc ctgggtgcag 2881 gtgcccacat tctgctaatg agagctttgt ctgatcagtc ctgggtccat cagtttgtcc 2941 atgtgtccgg ctgccagccc gtcccttggg atccttcccc tggggtgtag ccttgttcat 3001 tagtatatac tcattccttc atgctttcct cagcagaaca cttccacttc tgaggtgagc 3061 ttttgcccca tgcccttcct ccacaggtgt tgccttttta taaagacctg atagcagaat 3121 aaattggtgt ttccctgttg acccagcacc atttctgtgg gcctagaata tggccctcaa 3181 cccttagagt ggggcagtga gggcttgagg agtgaccctt cctttctcat ggttttagtc 3241 attttggctg ccagccctta atggcacaga tctgctgctt ctaacagatg gccaggaggt 3301 gacaccgatt tcagccattg ccaaggttag caccctctcc tttgagccta gggccacact 3361 gttcattgtc actttaggca agtgcctgtt tggctttaaa ggtaagcctg ccagctgtga 3421 gaagccttgg taactgatgg actcatttcc tggtccttaa agatgcagcc tcttaagggc 3481 tccttgatgg atgccatctc tcctagcccc cagccctggt gccactggtg ggcaggttcc 3541 cattctttgg ggctgggagg gacagcttgc ctgtttctgg tcacaaatta cagtcttctc 3601 tcctgtacca ttctgtggct tcagccatgg gggcagtagc ccttcattag tgtagatagt 3661 cattccctgg tagggtggag ggtaagacat agggtctgga actgtttggg accttttggg 3721 gatgtcctgt gcctcccaga ttcctcgatt ctgggaggag aggctgccgc attctgctgc 3781 tcctcacagc gagcaaagct gcacccactt acattcagta ttttcctggc actacaaaga 3841 gtgggaaggc ctgggatttg ctgctgctcc cttagagcag ggcccctctt ttcagcactt 3901 tggacacctg gagacccagc cctgttattt aatggtagtg ggcaagtgtg tgtgcatact 3961 gtctgccact gctttctccc tgccccatgc cagagagccc tgtccctgcc aggcccagcc 4021 ttcttagccc caacttggga acaaagtgca acatgggatc atgggttggg gtgctcaggt 4081 gagccctctc tatagtgctt ccctgggcca agctgacacc agcccctgag ggtggggtgg 4141 gacgggtggt gcttaaaaga ggaaggggac cagtgtagca acttgccagg gaccccaccc 4201 ctccctctct gggcctgtgc agtgagcatg gggattccca tcaaggggcc tggcacctgt 4261 gctagttacg tagccgctgc tcacgcgctc actcctgacc acatgcacgt tccctagatg 4321 cagactgctt tgaactttaa agctgtacaa tttggttatg tttgtgctga cttaaaatat 4381 attttaatga ggaaaaaata atggagaacc ctgggaagga cctggttctt ttgcttctcg 4441 gggaactgta agccctcgcg ttctgggaat cgctctctgc tgctctttcc tggaagctaa 4501 gcctgtctcc accgcccgag gcctgcgccg gtggctcccg ccgcagttgc gtttgctttg 4561 gaccttgcgt gcgggggagg gggtgctcgg tccgagcccg ctcctttctg tacacctagc 4621 gctgcccgcc ccgcttgtgt ctgaggtcgt gtatgtcaaa aataaagccg ctagaaacgg 4681 aggcgagtct gtctttgtga aaatcccgtg gcccgggagc cttccctggt caccctcggg 4741 gcgaggccgg ggccgtgggg cggggccggc ggctgctgga ccgcggcgaa gcagggaaca 4801 aggcctcgcc cttggcgcca gttccgcctt tggatccgcc aatggccagc tgacccgcgg 4861 gtcccggccc gggtctccat ggcagcccgg cgtactcggg cgctcattgg ctacgtctgt 4921 cgcagcgctg cgctccaacg ttccgacgcc ggcggccgtg ccacgtacgc ggcagccgat 4981 tggcccgcgg tggtcgcgtc actgcccgcg ccgggtccgg cctgagttcg gggccagcag 5041 ccgtctaccc ggtgtcgcgt tctgtgttgt ggcggccctg gatccggcgt cagggcgacc 5101 gggcggacga ggtggagcca gagtctgtca ggcgggttgg tgaagggcgc ggggccgggc 5161 acggcgttgg gagtgcgcgg cagggaccgg ccaggcgggc tgcaggcacc tcagagcccg 5221 ggacaccccc tcaacgtccg caggcgcgat gaaggcactg atcttagtgg ggggctatgg 5281 gacgcggcta cggccgctga cgctgagcac cccgaagcca ctggtggact tctgcaataa 5341 gcccatcttg ctgcaccaag tggaggcgct agccgcggta agaccctggg tcgggatcag 5401 agtcgcgttc ggatctggcg ggactaggga tggccagcga ctaggggtca ggggctcccg 5461 taccttctga ctgagcccgc ccgtcggcct gcgttctgac aggcaggcgt ggaccacgtg 5521 atcctggccg tgagctacat gtcgcaggtg ctggagaagg aaatgaaggc acaggagcag 5581 agggtgaggc acagactctt ggcccttatt ctcggtcccc gcccaacttc ccatcctggt 5641 agaacctgac tgggggggcc tcttccttcc agctgggaat ccgaatctcc atgtcccatg 5701 aagaggagcc tttggggaca ggtcagtaga ggcagaaagg tcccttgggg gagggtttaa 5761 ggccaggaaa agggtaagac ccagcctgga gtgggcctgc tgagcctgaa tccagggact 5821 cagacctcca gcaaggtggt gacctgtccc cttcccccag ctgggcccct ggcgctggcc 5881 cgtgacctac tctctgagac tgcagaccct ttcttcgtcc tcaacagtga cgtgatctgc 5941 gatttcccct tccaagccat ggtgcagttc caccggcacc atggccagga gggctccatc 6001 ctggtaaggc gccaggtctt ctctctcttg acactttcac cctccatgcc cagcctccca 6061 tgccccctag ccttcatctg ccttcggatg ttatggatac agagctgtgc agtatgtatc 6121 tttaagcact tggggcagag tctcttgaga tctggaacgg catgtgtatc aaggcttagg 6181 aacactggac taggtccgag gtccccttcc ttgcattcag gtgaccaagg tggaggaacc 6241 ctccaagtac ggtgtggtgg tgtgtgaggc tgacacaggc cgcattcacc ggttcgtgga 6301 gaagccacag gtgtttgtgt ccaataagat caacgcaggc atgtacatcc tgagccctgc 6361 agtgctgcgg cgcatccagg tgtgtaggag acagctgttg gtgggctggg gtggggcagg 6421 ccatcaccgc catgaccctg ctcacaagct gcccactccc acagctgcag cctacgtcca 6481 ttgagaagga ggtcttcccc attatggcca aggaggggca gctatatgcc atggagttac 6541 agggtgaggc agggaggcca cagggtgggg gtggtctgtg gctgggctga ggcccctgat 6601 gcatccctcc ctacaggctt ctggatggac attgggcagc ccaaggactt cctcactggc 6661 atgtgcctct tcctgcagtc actgaggcag aagcagcctg agcggctgtg ctcaggccct 6721 ggcattgtgg gcaacgtgct ggtggtgagg cccttgccca gcccatcatt aaccccctca 6781 gtcttgggag acaagtggcc cacttgtatt tttcccaccg ctctcaggac ccaagtgccc 6841 gcatcggcca gaactgcagc attggcccca atgtgagcct gggacctggc gtggtggtcg 6901 aagatggtgt gtgtatccgg cggtgcacgg tgctgcggga tgcccggatc cgttcccatt 6961 cctggcttga gtcctgcatt gtgggctggc gctgccgcgt gggtcagtgg gtaagcctgt 7021 gggctgggct gggtggggag aggggcgggg agtgtgcctg cctccctgac aaggcctatc 7081 ctctcctgga ggtacgcatg gagaacgtga cagtgctggg tgaggacgtc atagttaatg 7141 atgagctcta cctcaacgga gccagcgtgc tgccccacaa gtctattggc gagtcagtgc 7201 cagagcctcg tatcatcatg tgaggggatg cagtggggct ggccgagccc cggttttccc 7261 atcagcaagg ggagtgctgg cctgacacat cagaagaccc tggacttgtc attatttgtc 7321 tggggggcac tgggtgaagc tgaagctgtt ggacacctgc cttctcatgt ggacatcatc 7381 tggcaggatc cctgctgggc acaccccaca aaccccactc cctcaagaag ggccagggcc 7441 agggctgtat ggaataataa tttaatgctc actgtggccc tgactgaaag tcaagctcag 7501 gcacaattag ggccatggct gggctcccac caatgaggat acaggcaggc aaggaggttg 7561 gatgtggtgg tgtgggatac aggagaaggg caaagggagc tcataaatag ggcccagcct 7621 ggctctgggt tcaaaggtgg aggttccagg atggcacagg ctgtgagggc taggcagctg 7681 aggaggtagt actcgtattg gctcccttct cccagtcctc tacagacacg atggtggttt 7741 tgcagaagaa gcagtccttg ttgttcatca ggtgctggtt gatacaggct ctacaacagg 7801 ggaggggatg aggactgccc tgcatgtacc tactgctctc cccaccacca agctgtgggg 7861 cccacttact tgcaggactt gtggccacag ggctggaaca cagcagagat ggggtgggca 7921 tagcagatgg ggcagaggtc ctcctcactg gtgggctgca gggaggagag tgaagggtgg 7981 gctggagttg gatgcctggc tatgtggatg tccgttgtgc ctgtgtagga gtgcacacat 8041 attcaagtgg catggacctg tgcaccgtgt tcccactcac cagggaggca gctgctgcct 8101 gggcagatgc agaggtcagg tgcgccagca tctgttccac ttgggccagc tcatcggcac 8161 tgatataatc cgcatctggg gagtggtagg tagtgtcaag tcagaggtag ctgaggatgt 8221 gatgcctctt gaatattccc agcctaggac tttgctgttc ttaaggctcc tgacccgacc 8281 cagccccaga tttccctgac ctgccccacc agcccactca cagctctgca gggagaagcg 8341 cttccggtca ggggctggca gagcagtgcc aggtgctggg ggctctggct gtcccaggag 8401 atagcatatt gagcgtagct ggaagcaggg atctgccagg agcactgatg tggcttgctc 8461 tctcctaggt aggggagggt gcaagggcag tcagaaggct tggggcctgg ctaaaagtct 8521 ctcttgggat tgccaatgag gagtgccatg gctcgtacat gatcaccccc cctgcatcct 8581 ttccgtctcc ctgcttccca aaccccaagt cctgtattct agtaaggtgc cacacagcct 8641 gttttttttt tttttttctt gagacgagtc tcgctctgtt gcccaggctg gagtgcgatg 8701 gcacgatctc ggctcactgc aacctccacc tcccgggttc aagtgattct cctgctttag 8761 cctcccgagt agctggaatt gcagacgccc accaccacgc ccggctaatt gttgtatttt 8821 tagtagagac agggtttcac caggttggcc aggctggtct cgaattcctg acctcaggtg 8881 atccacctgc cttggcttcc caaagtgctg ggattacagg cgtgagccac cgcgcccggc 8941 ctggggtacc actttaagaa ggctcaggcg aaccacctta agatagtgag agtctgcctg 9001 ccccataata ttatcagtcc ttcaaagtca cttcaaataa acactaacag cagcttggag 9061 acattcttcc agactccccc ttttactccc cgaggaaaaa cgagcggcgg agagctgcca 9121 gccaaaggct gacggggact ttggggttgg ccttgctccc catctggcgg tcatgcgggg 9181 ccattgggca caaagggatg tagccgcccc gcctcctcaa acgggaacca ataggagccc 9241 gggccccgcc cctgggggga gtatttagga gccgatcagg aactcgcttg gagagggcta 9301 gcgaagccga agggagcgcg gctaagagtg ccgcaccgcc tcacaacctg ggaaccggag 9361 agtaggggcc gtcggctggc aagaacccgc cgtgcctcct cggcaagggc catccggtgc 9421 cacccatgtc gcactagagc agaagagggt gagtcctgga actgcaacct gcacagagct 9481 gctctgtact gtccctggt //