LOCUS NG_008029 12307 bp DNA linear PRI 10-NOV-2011 DEFINITION Homo sapiens cholinergic receptor, nicotinic, epsilon (CHRNE); and chromosome 17 open reading frame 107 (C17orf107), RefSeqGene on chromosome 17. ACCESSION NG_008029 VERSION NG_008029.2 GI:324120890 KEYWORDS RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC233723.2. This sequence is a reference standard in the RefSeqGene project. On Feb 26, 2011 this sequence version replaced gi:190358478. Summary: Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-12307 AC233723.2 27596-39902 FEATURES Location/Qualifiers source 1..12307 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="17" /map="17p13.2" gene 5002..10307 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /note="cholinergic receptor, nicotinic, epsilon" /db_xref="GeneID:1145" /db_xref="HGNC:1966" /db_xref="MIM:100725" mRNA join(5002..5058,5313..5455,5582..5626,5750..5859, 5989..6144,6451..6551,6886..7086,7169..7283,8494..8608, 8692..8878,8969..9075,9185..10307) /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /product="cholinergic receptor, nicotinic, epsilon" /transcript_id="NM_000080.3" /db_xref="GI:294862246" /db_xref="GeneID:1145" /db_xref="HGNC:1966" /db_xref="MIM:100725" exon 5002..5058 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=1 CDS join(5013..5058,5313..5455,5582..5626,5750..5859, 5989..6144,6451..6551,6886..7086,7169..7283,8494..8608, 8692..8878,8969..9075,9185..9340) /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /note="cholinergic receptor, nicotinic, epsilon polypeptide; acetylcholine receptor subunit epsilon; AchR epsilon subunit" /codon_start=1 /product="acetylcholine receptor subunit epsilon precursor" /protein_id="NP_000071.1" /db_xref="GI:4557463" /db_xref="CCDS:CCDS11058.1" /db_xref="GeneID:1145" /db_xref="HGNC:1966" /db_xref="MIM:100725" gene complement(5144..8423) /gene="C17orf107" /note="chromosome 17 open reading frame 107" /db_xref="GeneID:100130311" /db_xref="HGNC:37238" mRNA complement(join(5144..7839,7931..8140,8248..8423)) /gene="C17orf107" /product="chromosome 17 open reading frame 107" /transcript_id="NM_001145536.1" /db_xref="GI:224493722" /db_xref="GeneID:100130311" /db_xref="HGNC:37238" exon complement(5144..7839) /gene="C17orf107" /inference="alignment:Splign:1.39.8" /number=3 exon 5313..5455 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=2 exon 5582..5626 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=3 exon 5750..5859 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=4 exon 5989..6144 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=5 exon 6451..6551 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=6 STS 6464..6913 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /standard_name="CHRNE" /db_xref="UniSTS:510364" exon 6886..7086 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=7 exon 7169..7283 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=8 CDS complement(join(7543..7839,7931..8140,8248..8313)) /gene="C17orf107" /codon_start=1 /product="uncharacterized protein C17orf107" /protein_id="NP_001139008.1" /db_xref="GI:224493723" /db_xref="CCDS:CCDS45591.1" /db_xref="GeneID:100130311" /db_xref="HGNC:37238" exon complement(7931..8140) /gene="C17orf107" /inference="alignment:Splign:1.39.8" /number=2 exon complement(8248..8423) /gene="C17orf107" /inference="alignment:Splign:1.39.8" /number=1 exon 8494..8608 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=9 exon 8692..8878 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=10 exon 8969..9075 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=11 exon 9185..10307 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=12 STS 9416..9574 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /standard_name="SHGC-11989" /db_xref="UniSTS:28629" STS 9555..9838 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /standard_name="WI-19144" /db_xref="UniSTS:58046" gene complement(10015..>12307) /gene="MINK1" /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2; ZC3" /note="misshapen-like kinase 1" /db_xref="GeneID:50488" /db_xref="HGNC:17565" /db_xref="MIM:609426" mRNA complement(join(10015..10872,11263..11402,11488..11647, 11734..11883,11973..12073,12244..>12307)) /gene="MINK1" /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2; ZC3" /product="misshapen-like kinase 1, transcript variant 1" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_015716.4" /exception="annotated by transcript or proteomic data" /transcript_id="NM_015716.4" /db_xref="GI:259089410" /db_xref="GeneID:50488" /db_xref="HGNC:17565" /db_xref="MIM:609426" mRNA complement(join(10015..10872,11263..11402,11488..11647, 11734..11883,11973..12073,12244..>12307)) /gene="MINK1" /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2; ZC3" /product="misshapen-like kinase 1, transcript variant 2" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_170663.4" /exception="annotated by transcript or proteomic data" /transcript_id="NM_170663.4" /db_xref="GI:259089413" /db_xref="GeneID:50488" /db_xref="HGNC:17565" /db_xref="MIM:609426" mRNA complement(join(10015..10872,11263..11402,11488..11647, 11734..11883,11973..12073,12244..>12307)) /gene="MINK1" /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2; ZC3" /product="misshapen-like kinase 1, transcript variant 3" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_153827.4" /exception="annotated by transcript or proteomic data" /transcript_id="NM_153827.4" /db_xref="GI:259089412" /db_xref="GeneID:50488" /db_xref="HGNC:17565" /db_xref="MIM:609426" mRNA complement(join(10015..10872,11263..11402,11488..11647, 11734..11883,11973..12073,12244..>12307)) /gene="MINK1" /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2; ZC3" /product="misshapen-like kinase 1, transcript variant 4" /inference="similar to RNA sequence, mRNA (same species):RefSeq:NM_001024937.3" /exception="annotated by transcript or proteomic data" /transcript_id="NM_001024937.3" /db_xref="GI:259089411" /db_xref="GeneID:50488" /db_xref="HGNC:17565" /db_xref="MIM:609426" STS 10047..10272 /gene="CHRNE" /gene_synonym="ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS" /standard_name="RH76075" /db_xref="UniSTS:83674" CDS complement(join(10789..10872,11263..11402,11488..11647, 11734..11883,11973..12073,12244..>12307)) /gene="MINK1" /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2; ZC3" /EC_number="2.7.11.1" /inference="similar to AA sequence (same species):RefSeq:NP_056531.1" /exception="annotated by transcript or proteomic data" /note="isoform 1 is encoded by transcript variant 1; misshapen/NIK-related kinase; GCK family kinase MINK; serine/threonine protein kinase; MEKKK 6; MEK kinase kinase 6; MAPK/ERK kinase kinase kinase 6; mitogen-activated protein kinase kinase kinase kinase 6" /codon_start=1 /product="misshapen-like kinase 1 isoform 1" /protein_id="NP_056531.1" /db_xref="GI:7657335" /db_xref="GeneID:50488" /db_xref="HGNC:17565" /db_xref="MIM:609426" CDS complement(join(10789..10872,11263..11402,11488..11647, 11734..11883,11973..12073,12244..>12307)) /gene="MINK1" /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2; ZC3" /EC_number="2.7.11.1" /inference="similar to AA sequence (same species):RefSeq:NP_733763.1" /exception="annotated by transcript or proteomic data" /note="isoform 2 is encoded by transcript variant 2; misshapen/NIK-related kinase; GCK family kinase MINK; serine/threonine protein kinase; MEKKK 6; MEK kinase kinase 6; MAPK/ERK kinase kinase kinase 6; mitogen-activated protein kinase kinase kinase kinase 6" /codon_start=1 /product="misshapen-like kinase 1 isoform 2" /protein_id="NP_733763.1" /db_xref="GI:24850117" /db_xref="CCDS:CCDS45589.1" /db_xref="GeneID:50488" /db_xref="HGNC:17565" /db_xref="MIM:609426" CDS complement(join(10789..10872,11263..11402,11488..11647, 11734..11883,11973..12073,12244..>12307)) /gene="MINK1" /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2; ZC3" /EC_number="2.7.11.1" /inference="similar to AA sequence (same species):RefSeq:NP_722549.2" /exception="annotated by transcript or proteomic data" /note="isoform 3 is encoded by transcript variant 3; misshapen/NIK-related kinase; GCK family kinase MINK; serine/threonine protein kinase; MEKKK 6; MEK kinase kinase 6; MAPK/ERK kinase kinase kinase 6; mitogen-activated protein kinase kinase kinase kinase 6" /codon_start=1 /product="misshapen-like kinase 1 isoform 3" /protein_id="NP_722549.2" /db_xref="GI:27436917" /db_xref="CCDS:CCDS45588.1" /db_xref="GeneID:50488" /db_xref="HGNC:17565" /db_xref="MIM:609426" CDS complement(join(10789..10872,11263..11402,11488..11647, 11734..11883,11973..12073,12244..>12307)) /gene="MINK1" /gene_synonym="B55; hMINK; hMINKbeta; MAP4K6; MINK; YSK2; ZC3" /EC_number="2.7.11.1" /inference="similar to AA sequence (same species):RefSeq:NP_001020108.1" /exception="annotated by transcript or proteomic data" /note="isoform 4 is encoded by transcript variant 4; misshapen/NIK-related kinase; GCK family kinase MINK; serine/threonine protein kinase; MEKKK 6; MEK kinase kinase 6; MAPK/ERK kinase kinase kinase 6; mitogen-activated protein kinase kinase kinase kinase 6" /codon_start=1 /product="misshapen-like kinase 1 isoform 4" /protein_id="NP_001020108.1" /db_xref="GI:68161546" /db_xref="CCDS:CCDS45590.1" /db_xref="GeneID:50488" /db_xref="HGNC:17565" /db_xref="MIM:609426" ORIGIN 1 gcctcagcct cccgagtagc tgggattaca ggtgtaatcc cctggctaat tttttgtatc 61 tttagtagag acggggtttc accatgttga tcaggctggt cccaaactac tgacctcgtg 121 atccgcccgc ctcggcctcc caaagtgctg ggattactgg tgtgagccac cgtgcccgac 181 taagttttct atttttagta gagacagggt ttcaccatgt gggtcaggct ggtcttgaac 241 tcctgatctc aagtgatcca cctgccttgg ctgcccaaag tgctgggatt acaggcacga 301 gccacctcac ccagcccact attgcatttt ctatgttgtg gggtgtgtgt gtgatgtatt 361 gtttatacat gatgtagttg tggtgcttaa gttgaggatt tagcccatca tttggagaat 421 ggatggaaat cagacctgag tgaaactact tagagcaggg gacactggac tctgggctga 481 gagtgttttt tttttttttt tttttttttg agactgagtc ttgctctgtc accaggctgg 541 agtgcagtgg cgtgatcttg gctcactgca agctccgcct cccgggttca cgccattctc 601 ctgcctcagc ctcccgagta gctgggacta caggcgcccg ccaccatgcc cggctaattt 661 ttttttttta atttttagta gacacggggt ttcaccatgc tagccaggat ggtcttgatc 721 tcctgacctc gtgatccgcc cgcctcggcc tcccgaagtg cagggattac aggcgtgagc 781 ccccgcgccc ggcccggagt gttttcttga aggacccttg ccataatcac tttttttttt 841 aattccccca atcatttatc ctttaagtta ccaaccatgc aattacactc ttaagttttt 901 tttaacatgt acaatgaaat tattattgac tacagtcact ctgttgtgct atcaaatagt 961 aggtcttatt ctattttttt tgtacccatt aaccatcccc accatccacc tacctgccca 1021 ctacccttcc cagcctctgg taaccatcct tctactctct atgtccatga ggtcaattgt 1081 tttgattttt aactcccaca aataagtgag aacatgcaat gattgtcttt ctgtgcctgg 1141 cttatttcac ctaacataat gatctccagt tccattcatg ttgttgcaaa tgacaggatc 1201 tcatcctttt ttatgggtga atggtgctcc attgtgtata tgtaccacat ttgctttatc 1261 cattcatctg tgtttttctt ttttcttttt tttttaaaca gttttctctc ttgtttccca 1321 ggctaggatg cagtggcatg atcttggctc accattcatc tgttttttaa aattttattt 1381 atttatttac agatgaggtc tcactatatt gcccaggctg gtcttgaact cccaggctca 1441 agcaattctc ctacctcagc ctcccagtga tgaccaatga tgctgagcac gttttcttat 1501 acctgtttgg catttgtgtg tcttattttg agaagcgtct attcaaatct tctgccctct 1561 ttttgatcag attattagat tttttttctc ataatcactt tttgaagcaa gatttcaagt 1621 ttgaatcctg ctggggagga tagagtgaat ttatattaac tgtattaatt tatgtatatt 1681 tcatatattt gtatatattt cagctctagc agtgagaatg gcatcctggc aggccgtttt 1741 gggagctaaa catataggag aagtgggctg ggttgctaga gggtgaatta ccagacatgt 1801 ggtgtcaggg cctgccacac ccactatcca tcctaaacaa ggcagtctta ggccaacccc 1861 atgatccttc ttcagtgttg gcaccccaag ccctcagagc atcaggcagt agcaacggga 1921 acaaaagtgc tgcctctgca gagagaagcc aagaagttgg tctggggcta agaccatggt 1981 gaaatgatgc acaggtgacg agaaagcaga aactacacag tagaaagggg acatgcaaag 2041 tagggggaat gggcagtgct gacgaagtga gaggagcaga gagcggacag agcggcagag 2101 acagatcagg agacaggctc tggagctgcc ttggcctctg acactggtct agtaagttcc 2161 agtccatgtg caagactaca ggaaacctag gagaaacttc atttttttgt tttttgagat 2221 ggagtctcac tctgtcaccc gggctggagt gcagtggcac gatctcggct cactgcaacc 2281 tccgtctccc aggttcaagt gattctcctg cctcagcctc ccgagtagct gggattacag 2341 gtgccagcca ccacacccag ctaatttttg tgtttttagt agagatgggg tttcaccatg 2401 ttggccagac tggtctcgaa ctcttgacct caggtggtcc acctgccttg gcctcccaaa 2461 gtgctgggat tacaggtgtt gagccaccgc atccagccgg aaacttcatt tttttgagat 2521 agggtctcgc ttgtcaccca ggctggagtg tagtgtgatc gtagctcact gtgtccttga 2581 tctcttaggg tcaagcaatc ctcccgcctc agcctcctaa gtagctggga ctacaggcat 2641 gcaccatgat gcctggctaa tattttttgt tgttgtttat ttatttttgt agagatgggg 2701 ggtctcactg tgttgcccag gctggtcttg aactcctggg ctcaagtgat gctccagcct 2761 cagcctccca aatagttagg attacaggca tgagccactg tgcctggcca aaaccttgct 2821 tttctgacag atctgattca ccctagctac agattctata gcacctgttt atttttatgc 2881 ttctcatagt ctggcatcac tggctgttga taggtctctg tcattagatg ataactcctt 2941 gaggcttgtt ttatccatct caataaccgt agcactcggc cctgtaaggg ggaactttgt 3001 aggtgtccac tgatgtttga ataaatattt gcatttatca caattcttgt cccaagcctt 3061 gacgcggaag ctctggaata agcagcagca cagatttgag acttagtcca tgtaccagcc 3121 acatgcaaag aggtaagctg ggtcaaagag acccagaaag ggagtctgaa atggaaatcg 3181 tggggttgat aaggcagcag tggaaacaga ggctttacac aagtgtggga aatggactag 3241 gaggacactc tgttatttga tgtgtcctcg cttgtaacat ggaggtgatt atgacctacc 3301 tcataggtgg gggaaggaga cccaaaggtg atggacccga aagtgttttg tgaagggtaa 3361 aataaacaca ggtgtgcgag atcaatagag ttgattgata agtctcatgc attattgcca 3421 atctacttgt gtgaccctgg atcccgacct tagcatcccc tttcatgtat tcaggacagt 3481 gatcattgct ttgctggact gctgtgagga aatgagatgt aagcagaaaa tatgcttagg 3541 ccagcccctc ctacctcacg aggaacacct ggacagtttc ctaaaaatac agattcctgg 3601 caccctagtc ccgaaatcat aattctctgg gaatggagcc taggaatctg aatttaaaat 3661 aagcacccct ccaggtgatt agaatggttc aagaaggctt taaaaaacac tgaggccggg 3721 cgtggtggct cacacctgta atcctaaccc tttgggaagc tgaggcagga ggatcgcttt 3781 agcccaggag tttgagagcc gcagtgaact atggtggtgc cactgtactc ctgtctgggt 3841 gacagagtga gatcctgtcc ccccaccccc tgcaaaaaac aaaaaacaaa aaaagaaaca 3901 gaaaaacaaa aaacatcgag gctgggcgcg gtggctcacg cctataatcc cagcactttg 3961 ggaggcccag gtaggtggct cacgaggtca ggagatcgag accatcctgg ctaacatggt 4021 gaaaccccat ctctactaaa aaatacaaaa attagccggg catggtggca tgcgcctgta 4081 gtcccagcta ctccagaggt tgaggcagga gaatcgcttg aacccgggag gcggaggttg 4141 cagtgagccg agatcatgcc actgcactcc agtctgggcg ccagagcgag acttggtctc 4201 aaaaaaattt tttttaaaaa ggaacatcaa aaggatctat taaggtgtca tcaggtgtgt 4261 gtgtatgtgt gcacgtgtgt gtttaggaga gtaggatggg aagacggtac tatcatctgt 4321 gaccacaagg tggcagcagg gatagacaag gagaaacaag tctcccaccc agaggggctg 4381 ggcatgggca aacctggcga tcaggttgtg gaaggaggtg ggtcctttac atgatctcct 4441 ttgctagatg gaatctctgt accgcagggc taatcccctg tgaccacctg tctctttatc 4501 aggtctttat ggagactgtt ttttgccact ctgtcggcaa gaaaggcatt gtgagcttgg 4561 gtggtgatag tgtgtgttcc acatgggtga gaatgggagg caaggggtgt gtcacatccc 4621 cagatgtgtt catcagtcag ggtcacctac acagggcagc ttactcaaag gacaacagtg 4681 cctgctgaaa gcagtgtctc ccaccccctg ctactagaat tgtggttgca ggtgcctctc 4741 aggagacgcc cacatctgtg gctggggagt tggccaaata ccaggcaaag gacgctgggc 4801 tggggcgggg caggggcagg aaacacagga tggggcagct gcctctggaa gcagccaaaa 4861 tgtccccagc tgcagcaggg gtgagcagag gattaggtga cagtccccta acagcccgga 4921 actaacaccc tcctccccct cacacaggca ccctggcatg ccccctccaa gcctgccaga 4981 gctcagaata accctgagaa ccacgcagca ggatggcaag ggctccgctt ggggtcctgc 5041 tcctcttggg gcttctcggt acggacaggg gctagagggg caattggaca cacacagata 5101 ctgacatgaa gggactggga agacaaagac agagaccaag atggagactt agacacagta 5161 tttcgttccc aggcacagca taattggttt aggagacaga tactgatagt acacagcctc 5221 agaggcctgt gaggacccag gggaggcaga ggggagagag gtgctccagc ctcttcattg 5281 ccaatgaccc ttccttcttg accccatcgc aggcaggggt gtggggaaga acgaggaact 5341 gcgtctttat caccatctct tcaacaacta tgacccagga agccggccag tgcgggagcc 5401 tgaggatact gtcaccatca gcctcaaggt caccctgacg aatctcatct cactggtaag 5461 ctacccccac cctcatctta agccaaaaat cccacttctg gccccaaccg ctgagctctg 5521 tcctaaagct cacttctggc cctgaaatct cacttcaatc atccccatct cccatctgca 5581 gaatgaaaaa gaggagactc tcaccactag cgtctggatt ggaatcgtga gtcaaatctg 5641 gggaatggtg tgaggtcttg tccagggcac cccttttccc ccaaacccct cccaggcagc 5701 gccaggtggg agatgcaggg cacgcggcct tccatccccc accccttagg attggcagga 5761 ttaccgactc aactacagca aggacgactt tgggggtata gaaaccctgc gagtcccttc 5821 agaactcgtg tggctgccag agattgtgct ggaaaacaag tgagaaccgg gccagacgcc 5881 aggctggagg gaagccggcc tggggtgcgg gctggacttg gttggggaag ggggtactct 5941 gagagggtgc agacctgtgc aaaaagctcg gtttccccga gcccacagta ttgatggcca 6001 gttcggagtg gcctacgacg ccaacgtgct cgtctacgag ggcggctccg tgacgtggct 6061 gcctccggcc atctaccgca gcgtctgcgc agtggaggtc acctacttcc ccttcgattg 6121 gcagaactgt tcgcttattt tccggtggga agagctactc cgaggcccgg acgattattg 6181 ttgggggggg gccttatggg gcggggccaa ccgggaagca ccgccctcgg ggcggggctt 6241 cgcgctggag gcggagccag gcgtaggcac tgggtgggac gctccagcgc ggccggaggt 6301 acagatggga acagaggcgt gcgggctggg cttgggtgaa ggggtgggct tgggatcgcg 6361 gccccgctag atcccagctt ccagggctgg gcctgaggcc ggggcccagg tcagagcttc 6421 tggggtgggc tcccggccct ggctccgcag ctctcagacg tacaatgccg aagaggtgga 6481 gttcactttt gccgtagaca acgacggcaa gaccatcaac aagatcgaca tcgacacaga 6541 ggcctatact ggtgaagccc ctgcctgctc agaaaaaccc gcttctagac ggggtccaga 6601 gaggggactt ccacggtggg cttgccccgg accaacgaca ctggaggatg acttccacaa 6661 ctgggtttag cttacccctg tcctgaaatc attctcgatt gttactctag tcctgccttc 6721 tggctttcca taccctcaac gagaatgccc ttttctgtcc gtaattgccc ccatcctgac 6781 ggcccatgac cctggtgcag acagccgcag cctcctcttc agcccgctgt cagctcggcg 6841 ggcgccccgc tctgacagcc agctgaccgt gcccccgtcc cgcagagaac ggcgagtggg 6901 ccatcgactt ctgcccgggg gtgatccgcc gccaccacgg tggcgccacc gacggcccag 6961 gggagactga cgtcatctac tcgctcatca tccgccggaa gccgctcttc tacgtcatta 7021 acatcatcgt gccctgtgtg ctcatctcgg gcctggtgct gctcgcctac ttcctgccgg 7081 cgcagggtaa gcagtggccc cgaacctacc cccaaacccg ggctcgctcc cgggaggcgg 7141 ggcccgctct cactggctct ccctccagcc ggcggccaga aatgcacggt ctccatcaac 7201 gtcctgctcg cccagaccgt cttcttgttc ctcattgccc agaaaatccc agagacttct 7261 ctgagcgtgc cgctcctggg caggtgaagc cggagccccc gcgggggtgt ggccagtgtg 7321 aagggtgggg gcgtggccaa aacccagaga ccccgggaaa agctctggct gtctcgcccc 7381 gccctgggct ttattcggac gctgggtggg gctggtacgg ggatggagtc cctggtccgc 7441 cgtcctcctc actgctgctg gacgtcacct ggaggtctcc cgagtagctc tcttggggga 7501 cagtccggct cagtgcctcc ctagccccgc cgcctctggc ccctaactca ccccgtgtcc 7561 tgagctcacc ggttctccgg ggattccgag gcctagctgc tgttgcgact gtcgcaggaa 7621 tgaggcagac ccctgcagac cccgtccaca caggcatagc catgctccct ggactaggag 7681 ccgggcgctg gcgcccaccg cagccccagc ttgccgaacc ccctgccctg cggcttgggc 7741 tacccggctc agcgctgcac ccggatccct gccgtctggg gctgggcccg cgctgccgtc 7801 tagtcgccgc gcctcctgct gcagccacag ggctgagatc tgcattgggg gcacaggggt 7861 tagcggggag gcagaggtcc ttgttcccgc tacccgatcg ccgcgtatcc taagcccccc 7921 agtaccccac ctctaacaag gtggtgccga agctcacgag gctggctgtg gcttctctca 7981 acaccagccc cagggtgggc ttcggggcag gcagcatccc ctgcatcttc ggttcgggtg 8041 gctccaggga cttcagctct ctgaacctct gctccagata ttcatgggct gcggccacgg 8101 agagttccag ggaagacaga agcgggggct ggagggccac ctggagaagg agcagagcag 8161 tagagtagca gggcaggggt cacaggggcg aacaggagac ctacccagaa ggtctcgagg 8221 tgcagccctt ggcgggcgta gcctcacctc ggtggagctg tggaagtggt agatccacat 8281 cagggtgtcc agggagctgg gggtcccctt catggccgcc acaagtggta ggacaggaga 8341 agggctgggg gacgcgtctg tcgtcgtgta gggggcgcag ctggagggcg taaccagccc 8401 gtaccaggag aagccgtgtt tgtgaggtca gcgcgcggcg ccttcggtag ctgggaggag 8461 gaacggtgat gtcatgcctt ccgggctcct caggttcctt attttcgtca tggtggtcgc 8521 cacgctcatt gtcatgaatt gcgtcatcgt gctcaacgtg tcccagcgga cgcccaccac 8581 ccacgccatg tccccgcggc tgcgccacgt aagcgcggag ggggcggtgc agcccgggtc 8641 ggggtggggc ttcgtactaa cctcgtcccc taagccccgc ccctgcccca ggttctcctg 8701 gagctgctgc cgcgcctcct gggctccccg ccgccgcccg aggccccccg ggccgcctcg 8761 cccccaaggc gggcgtcgtc ggtgggctta ttgctccgcg cggaggagct gatactgaaa 8821 aagccacgga gcgagctcgt gtttgagggg cagaggcacc ggcaggggac ctggacgggt 8881 gagcacagtg gccctggccc ggggggccgc gcggggtgcc tgccaggggg gaggctccta 8941 aggcccaccc cggtgttttc cccgccagct gccttctgcc agagcctggg cgccgccgcc 9001 cccgaggtcc gctgctgtgt ggatgccgtg aacttcgtgg ccgagagcac gagagatcag 9061 gaggccaccg gcgaggtggg acaggagcca gaggcgggtg gagcgaggca gaggcccacc 9121 actgtctccc atgccgctgg ctcctgcagc tgcctcttta ctgactgtgc cgacccttcc 9181 ccaggaagtg tccgactggg tgcgcatggg gaatgccctt gacaacatct gcttctgggc 9241 cgctctggtg ctcttcagcg tgggctccag cctcatcttc ctcggggcct acttcaaccg 9301 agtgcctgat ctcccctacg cgccgtgtat ccagccttag ctcgcaccga cttcaatttc 9361 ccacccatct ccagtaggaa attgattttg aaaaagtagg ctgccgccac cacggcatta 9421 tgatcccttc cccctgctga tcaatctgca gtttgtgaac ttcacaagaa tggtgtgtgc 9481 ccgttccctg gcgtgtgtag gcctggccgc agtccagggg tcagcaggag gaaagggttc 9541 acataggctc tcaggtgcca gtcttccaga aagcaaggac tgcccttcat tcagccttgc 9601 tgacctccca gcctttctaa ggctcagccc cacgggactc tggtggctgc cagcttgtga 9661 gctatctatc tatattcatt tcatagccaa acaggagacc cctttgcagg acttgcacac 9721 agggaggctg tagccaggaa accctcttct tccctggtct ggctctgctg gagcgggtgg 9781 gaaccaaaca ccttcagtgc tggtggccct caggcccaca ggtttaaggc tgaggctgcc 9841 ctgacccttc cacagtcatt tcttctaggt tttcttggcc cagcactgcc catcccaccc 9901 catgaggctc actcattgca gatcccagcc caccctgccc ctttcttccc caccctggag 9961 gctctctctg cctagtctac agtactgaca gaaagcaagg acatgcggcc tgcatggtgg 10021 gagctggttg aattgtcttt attaacaaac aggatatcca aggccactac attgaggagg 10081 ggtggggggg gagggagaag ggttacttgc tgctcacact atatacagat gcaagcaagg 10141 ggcgtggaga gtgagggctc cctgctccct ccctccaccg gggaagggca tgggctagaa 10201 gaggagaggg gggtcgggaa tggggggaat gttttggctg gcggggtccc ccctccattc 10261 cctggagttt gggggaaggg gaatcattaa agtgctttca gaaaatgaag aaatggtccc 10321 tgcccctgga gtggctggtg accccccaaa aatctagggc ccagtgaccc cccccagggt 10381 ctggtacatt caagggggga gccggctccc ctgacgtgca aataaagggg tccagggccc 10441 tgcccagtca gcagcagtgg ggtaaggggt tcaagcccca agcactctcc tctcaaatgg 10501 agaaaagggg ggaggggcta ggcccactca attcctggga aggggaagct gtgtccctcc 10561 ccagaagctg gggacaggca cagttttggg aagaggacat gttggggaag aggatggtca 10621 cgtgatcacg aaagcatcag gggtcagagg tcacgttccc agcaggctcc agtgaaatca 10681 aaccagtaaa agcaaaagcc cagggagggg aaagaggggc ggcccgggaa gcctggctgc 10741 agggggagag ctgggtccag tgtgggacag ccccagccca gggccccgtc accagttcat 10801 gatgcagtta cggttcagag tcatgaagta aacttggctg ctgcccccag agcggactga 10861 ggcaaaaaac acctgggtgg ggcaggagaa gaagtcacca agggctgagg ttgggggggt 10921 gtctcaactg ggagagggaa agaagggaag aaggggtggc agaagagttg agggagacac 10981 agagactgca ggaggagact cacagtgccc ctcacccgga ggaaaggcag gctgggatgt 11041 taggggagag ggtgcaccac tcgccccctg ggggccagct gggaagtcct cggaatctga 11101 agggagcgca gggcagtggt agtggctgac tgccctctga gctcccagag gggcccgctt 11161 tcaggaagcc accaccacca tcctctcccc agaactctgc ccaggggcct agggtcatgg 11221 cagccgggac agcagggctt tcagagggaa ggagcctccc accttgtcat tccgctcaca 11281 caggaacttg agcctctgag ctcgtttgtg catgaagacc ccgtcgaggt ggcccgtctc 11341 cacagagcgg atctcaatgg ctttctcacc ccagcccatt atctggttgg agcagatgta 11401 ggctgtgggg aacaggtgag gggctgagca ggctgcaccc cggggccacc tcggggcatg 11461 tggctgggag ggcggcagct cactcaccca cagaagtagg catctccccc cactgcagca 11521 ccacatcctt aatgatgcgc ccgtacgtgt tgacgtagac accctcgtcc tcgtagcaca 11581 gcagcatctc catgccgtcg gtgttgggga ggaagatgat ggcatggggc gtgatctggc 11641 tctggatctg gggagaagga gggggactag agtctccgtg tctggtgccc agactgggcc 11701 atcccactcc cccagcagcc ccgccaagct cacgtgcaca gggatgtaga tgtcatagct 11761 gttccccgag tcgacatcca cagcatggaa gccagcactg gagccataga tgaccttgag 11821 ccgctgcccc tcctctactg tcaggtcgac cagcagaggg cggtggggga ggtcggcaaa 11881 ggactgcaga gaaccggagg agaggagggc tcaggggcac ggggagaggc gctgggactc 11941 cagatggtgt tagggaccga ggctgggatt accttgaagg ccatgaattt gtggtagggt 12001 ttgggggccc aggcatacac ctccacggag ctcttgaggg cgatgaccag gaacttaatc 12061 cgctcgtatt tcactggggg cgggagagaa gagggatgct gagacttccc ttcttgcgcc 12121 acgggcgcct ccccgtggtc tgtcactaca ctgccccacc caggccccaa gtccctggct 12181 cccagatcca tttctctctt catgaacaag tatgcgctgg ccactctgtt gggacatcct 12241 caccaacacg gtagtgcccg cagccctcca tgtcccccac ggtggtccag ccctgcttct 12301 tctccac //