LOCUS NG_008172 23881 bp DNA linear PRI 30-JAN-2011 DEFINITION Homo sapiens cholinergic receptor, nicotinic, alpha 1 (muscle) (CHRNA1), RefSeqGene on chromosome 2. ACCESSION NG_008172 VERSION NG_008172.1 GI:193788647 KEYWORDS RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018890.13. This sequence is a reference standard in the RefSeqGene project. Summary: The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-23881 AC018890.13 45803-69683 c FEATURES Location/Qualifiers source 1..23881 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="2" /map="2q24-q32" gene 5001..21881 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /note="cholinergic receptor, nicotinic, alpha 1 (muscle)" /db_xref="GeneID:1134" /db_xref="HGNC:1955" /db_xref="MIM:100690" mRNA join(5001..5121,9840..9985,10098..10142,11453..11527, 11798..11907,15059..15254,15733..15970,19304..19527, 20654..20893,21218..21881) /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /product="cholinergic receptor, nicotinic, alpha 1 (muscle)" /transcript_id="NM_001039523.2" /db_xref="GI:189571658" /db_xref="GeneID:1134" /db_xref="HGNC:1955" /db_xref="MIM:100690" exon 5001..5121 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=1 CDS join(5079..5121,9840..9985,10098..10142,11453..11527, 11798..11907,15059..15254,15733..15970,19304..19527, 20654..20893,21218..21349) /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /note="isoform a precursor is encoded by transcript variant 1; cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle); nicotinic cholinergic receptor alpha 1; acetylcholine receptor subunit alpha; nicotinic acetylcholine receptor alpha subunit" /codon_start=1 /product="acetylcholine receptor subunit alpha isoform a precursor" /protein_id="NP_001034612.1" /db_xref="GI:87567783" /db_xref="CCDS:CCDS33331.1" /db_xref="GeneID:1134" /db_xref="HGNC:1955" /db_xref="MIM:100690" exon 9840..9985 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=2 exon 10098..10142 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=3 exon 11453..11527 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=4 exon 11798..11907 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=5 exon 15059..15254 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=6 STS 15137..15868 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /standard_name="CHRNA1" /db_xref="UniSTS:510363" STS 15149..15871 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /standard_name="Chrna1" /db_xref="UniSTS:531496" exon 15733..15970 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=7 STS 17804..18086 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /standard_name="D2S1411" /db_xref="UniSTS:81579" exon 19304..19527 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=8 exon 20654..20893 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=9 exon 21218..21881 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /inference="alignment:Splign:1.39.8" /number=10 STS 21351..21576 /gene="CHRNA1" /gene_synonym="ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS" /standard_name="D2S2716" /db_xref="UniSTS:25321" ORIGIN 1 agagatgggg ttttaccatg ctggccaggc tggtcttgaa ctcctgacat caggtgatcc 61 acccaccttg gcctcccaaa gtgctgggat tacaggcgtg agccaccacg cccagcctcc 121 aacttaatgt tagttctctt ctcttttctg cccatactga ttcctttgac cttatcctgt 181 tgtggcttta aacaacatct actctagatt tcccaaacta ctgactcaaa aatccaactg 241 cctgctcaca tttctaatgg acacctccag ttgatcacac cccaggcaga acccttgaat 301 tttcccccct ttaaacctgc tcatccacgg tcttccttaa tccacttgtt ggcatttaaa 361 tccttcctta tgctcaagcc aaaaccctgc aaatcatctt aaatgcctcc ctttttcttg 421 cattctagat caaatccttc aggaaatccc attaaccctc acgtcaaaat acatttccca 481 aatctaacga cttcttacca ccttcactgc aaccactctg gtccaattca tcaccatcta 541 cctcagggat tactgcagta gtagctccta atttacaccc ccacagcctg gtgtccccaa 601 agcagccaga gtcgaccttt gacagcatat gtcagatggt gtcacccttc ggctcaaaat 661 gctgcagagg ctcctcatct cacagagaat gaaagtcgag gatgcgtgtt gcgtccccct 721 tccctgggct gctccctgac ctcatctcct agcagtttcc ccatctctcg ccctgctcca 781 gcctgccagc ttcctggcta tgcccgagat caccagtccc attcccctca gggactgcgt 841 tgctgctcac tctgcctgca atgctcctgc acagatatct gtctgcatct ccttcaaacg 901 ccacctcctc agtgaaaccc accctacctg ctgtgtttaa aattgcaatc cccttccagc 961 tgtcctggtc cccttttatc ctgctctgct ttttcttttt cctatagcaa tttttacctg 1021 atgacacatt aaacaattta cttattagtt ataacaattt acttatataa attatatata 1081 tcttatttat ataacatata agaaaaaata tataaaaata tatattttat ataaataaaa 1141 aatatacatc tttttacaat ttatatatta tatatgttta catgtataat ttattgtata 1201 tgtttacata tataatttat tgtatatgtt tacatatata atttattgta tatgtttgta 1261 tattatatat aatatataat gtttatatat tatgtatgtt tatatataat atatgtattt 1321 catatataaa tatataaata tatttatata tacatttata tatattttat ttataatata 1381 tgtatatgta tatataatat atgtttatat ataatatatg taaacatata atacatgtaa 1441 acatatatgt aaacatatac agtcaaacat atatgtatat atataatata taaccatata 1501 ttatataaca tatgatataa aaataaattg ttaaaaggat atatatctta tttatgtaat 1561 atataacata tgtaatatat ataaaaataa attgtaaaaa atatatattt ttttaatcat 1621 ccatctcctc caattagaat gcatttttcc tgagaaccag gaatctttgt ctgctgtgtt 1681 tattgatgta ttccaaatgc ctagaacact gcttggcaca tagcaaaacc cagtgaaaaa 1741 atttttagtg aatgaatgaa tggaatgcat ggaaacaggg tctgaacaga cacaaactaa 1801 aacatcaaaa taaatattct gggtagaagg atagcaggtc ttttcattca tctgttctct 1861 aatttctcta aaataaattc aaattacttg aataataaac ttttaaatga aaaaaacagt 1921 ttactcctga ggataatatt aatagtagtt ttagtaattt tttttagtct atggtttcaa 1981 ctgttcacct ttagaagaga tttttttgtt taaattgtgg gagatcacag tttgtttaaa 2041 ctgtggcaat aaagggggaa agcctccaat gatatcactg tgaagacccc atgccaggca 2101 gtgggagaaa ttctgtcttg agttgaggtc cccctgaccc tgtattgagt tgacttgaga 2161 ggtggcagat tggggagaag agacagagaa ggagaggaag ccaataaagg gagggttatt 2221 gagccatttc catcatgggc aacaggaact cactcccaca gacatagagt gtagggcacg 2281 cttgggggtt acccagtcca aggggagatg gggcggggat atttatcctc caacattggt 2341 tgaggcctgt ttctggaggc agtaacactt tagcatctca ggcttgtttc atgtgttccc 2401 atggccaaaa aaaaagaaaa aaaaatccct cggttacagg gttgcaggca ttggcagtaa 2461 gcagaaagcc agggtaggca cagagaaggt ctcaacagat tcctcgattc gacccgattc 2521 tgctctgtgg gtggaactcc cttgtccgtt gctgtttgag gttcctggct atgccccggg 2581 gaggttcttc cttgcccact ttccctcacg gccacaattg aaggagggga tggagaaagc 2641 accctttttg gaagactgtg cagatcttgg agcctgcttt ctggccgtgt gtgtttggga 2701 actcaaggac tgctttaagc cttgaacaac caaaactttt gtagcctggg ttaatgaact 2761 ctttggcaat ataattcctt caaatactga gtaagcttct gcaatatttg tttccatcat 2821 tcccatgtgc ctatatacac acatggtcac aattctttaa tctgattaat ttctttgcat 2881 cctaaccact atacctctct ccttcaactt aatagcagcc atcttgaagc catctgaaaa 2941 aaaaaataga tttggctgtg aagaaagcac ccttaaagtg atctttgctg tggtgatgaa 3001 actgcctgtt taaagagaag tcttaacggg ctttggttgc tcaaagcctt tattccatgt 3061 tttcacttac tcttttgaag ttcaaaacag aagactccac atttctggac tcattctatt 3121 tcttttcatt tctgctcttg aaccagcaca tttttgcctg agctcagctc ttccttgtac 3181 tgacttgcta aacaaagcca gaaagagcca tggtgcacta actttgggtt taccagcctc 3241 tattctggga gctacaggct cagtagacac attgttcacc aagtaattga ggacaacagt 3301 ttatgaaatg atttgatacc atataacatg ggtcttcata ttttcagcct ccagtatcaa 3361 ttttcttgcc ttctgctgca gtgctacata ttttagaatt tatttttaac ctcaggatac 3421 tagtgcaaag gattacatat tttattaatt acggaacact agctgctgta caaataaacc 3481 caaggatttt gatggctcag cacgatgcat gttttgtttt cattgaaata gtgctgggtg 3541 gtgagcaggt ggataggggg tccccctcca tgcagtcatt caaggattca gaatgtcaaa 3601 agcaacacca ccttcagaac atggtttcta aggttaactt tgggaccatg tccattctag 3661 ccggtcagaa gactagaagg gcggggctga gctctggtag gtttgtgagt ctgagaacat 3721 ttttccactc atgccactgg ccagaggtca gtcccatggc tccatttaga tggaaggggc 3781 tggtcagagg gtgggggttg tatttctgcc acggggctat tccatggaag ggagagaacc 3841 aaattttttt ttagcaaaca gttaactgat ctcccacagt ttaaacaaaa aatataaata 3901 gtatgagctt gcagctctct cctctaccct ccaagcccct tctctaatga tttgtttgga 3961 tccactggaa tgagaggatc tgtcaggatg ttgttgtggg cttgaggtga gaggaccttt 4021 ctcacctagt tccatgtggg aaggaggcct ggaaggaaca ggcagggtac ctttaagtaa 4081 ctgtctcctt ctgggaactc acctcacacc ctgcaaagaa gcacagctag ggtaacaata 4141 cttctcagac tgagaaatta ctaactgctg gtttttagga tgtttttcaa gcaagataat 4201 tgaaaagctg aaccactctg ctctttgctt ccctgagtga gagtaggcag agggacggat 4261 ggaaggaggc aggaacccgg aacgactgct gatgcggtgg gacacttttt cccaataatt 4321 actcttcgct tgaatcacag tgcataggac gtgggcaatt tgctccagct aatggttcgt 4381 gtgggatagg tattgcctga tacagaggca ggggttggaa cagccactct gggggccagt 4441 aaagccagtt ttatggaaga agctgtcttt gttaaaaacc aaacccaatc aacgtggggg 4501 cttcccagca gcagactcaa caccagctac acttttctga aatccaggca gtcagaaaag 4561 cccccggcac cctcagccta acactgaagc agaggaaatg aaactgaagc catgtttgca 4621 gaatgtggat ttttgtggtt taggacaaac agctgactat ctactcagac caaatgaccc 4681 taatcaagtc aacccacaga gatgaggttc tggtttacac aaaagagagg cagtttgctc 4741 accatttaaa ataattcctt ccttcctata catttttttt tcattaagat ctgactactg 4801 gtgcatttaa aatataatgc agttcatact cagcttgtca agggtaagca attgtgtaaa 4861 gtgaggcata tctgtaatgg tgtacagtcc cagtaactcc ctgggctcca gggctgaggg 4921 cagcccagct gtcgctccca caaacaggtg gtgtaaaaca atagctctag tgagccgact 4981 cgctttccaa accctccagc agacaagcac ccagccagag tgccagtgag aagcacaggc 5041 caccactctg ccctggtcca cacaagctcc ggtagcccat ggagccctgg cctctcctcc 5101 tgctctttag cctttgctca ggtaagtgct ggggtcaggg gtggggagag ggctctcctt 5161 tgaggctaaa gtgctggagg cccccaaatc aaagtcttgc ttctttgatg agaccacaga 5221 atggcagagc ctccccaacc aggggctgct ctgtcagttt cttcctgatg ttagcttgat 5281 tgagtttttg gataaagatt tttagtttgc cttatctaat taaaatagaa actgcctggt 5341 caaagacttc aagatagaca cgcatgtctc tccctccatc atgcctggca gccgactcat 5401 ccctctgaac actcggcacc atttgtagga cctggaccac ttgtggatca tggtagtgtc 5461 cgggggttca tatttaaaca actatggata cttagaacag tgccttataa tcacatacaa 5521 tggagttaac aagtcccttt actgctccag gagaattcta ataataaaga ggactgattg 5581 acagctacat gtgctggaga tagaaaccag ttaataatca taactaaact ctctccacag 5641 agacaaatat tttttaattt tttcaaaatt tctgaagtta aaaaaaattc catatgaata 5701 cattcctacc tacttttttt ttttaagatg ttactatata taggtttggg tttgaattga 5761 aactataaaa ccttgcacag catttgacct gcattctact ctggaatgtg tcctaacaca 5821 gcagctgaaa caccatcctg aatcccagac ttccgctaga gggaaacagg agatgtttgc 5881 tgattgcttc acataaaagt ttactggtga tatcatccca actgagaaac aaggtggctg 5941 acatcctgtg atttttcatt tccaatattg ctctgaaaaa cacaggcctt ctggtcaaga 6001 ggcaaaaagc tttattatta atttttttca atatcagagt tgagtgaaag agcctaaact 6061 cagataaatt atatcatgtg ggatttggac tctgtccagc caaagctggc ctgatgtgtg 6121 tgtgtgtgtg tgtgtgtgtg tgcgcgcgcg tgcacacaca tgcgtgcacg caaaaccaca 6181 gtcacaggaa aattcttaaa tgatatgctt taatgtaaac atccttaaga gatctcttag 6241 gattttggtt attgctaacc aaaaatgcat gattagctat taaagaagta tgtgatatgt 6301 atttaggtca aatctcgagt ttgctggcat tgatttccat gggtgtttta tagaaattta 6361 gagctagatc aggcagtcca acatcctcaa ttttttatta caaggaaact aaagctgacc 6421 tgcccaaggt cacttaattt atacattttg gaatgtggtc agttggagac ttggtttatt 6481 acatgcacag tcagaaaaca cagcctgaac tagccaaagg tagcaagaga tacagaatca 6541 ggttaagata ataatgatcc atgggactag taacagttca aaatttcttt tgcccagccc 6601 agggagctat ttcctacata caaatacaaa tggaaccagt gtggtacaaa aggaacactt 6661 tgaaactgtg gttgagtttc ccttcttaga atcagtcctt tgtagacaaa attgtcattt 6721 atatcaggga ctcttttcct gtgttagctt aacacagcgt gatctctgtt ctatttatac 6781 agcacttttc atttcaactt tttcttttct ttgcctctgg aatctcaagc acttcattgc 6841 cgtctttctt acggcatatc actttccaac ttgttcacag ttatttacgt aaatgacaaa 6901 tgtcaatctc catgagggta ggaagaagga ttcagttttg aatatctcga agctcccaaa 6961 acaatgcttt gcttacagta aatgctcaac aaatatttca tgaataaatt aatgttacca 7021 tcatctgaat aaagattaca aatataatct tgctaaaaag gggaatttga cattatttaa 7081 ttttttattt gcatatttgt ttatttacac cctacctttt tacaaaagta tttactgtga 7141 ttcgttgaat ccatgaagaa ctaatccaac tctccaggcc atatgggagt tgggaagaga 7201 atcatagagt tctgactttg agccctgtga gttttctatc actctaccct gtgctgggga 7261 ggaaaaaaga aaagaatacc agtgaaccaa tctaagaaat gaagccctcc ttccttagaa 7321 attccttatg gaaggaacag gcaccttgtt attggctagg gtgggaaagg aggaggtgac 7381 tgtctctgaa atgctgatta tgtctgcttc tgtcatcctc cccttcctct tagtgggcca 7441 tagggttggt ctgcatagtt ctcctgctac ataatgctga ccatctgctc tgccctctgc 7501 tttctaatat gttcttcctg tcaaactgga gtgaacagtc atttaaaaat aagcagccca 7561 aggcaaggcc aaagcaacag cttcaaattc aatggccaag gtgctcagta atccattcca 7621 gtctgcaact ccaccatggg atggatgagg cccaggatag aaaatgcata gaggacagaa 7681 ggattatcaa gtcccagggg ctcaatgggg tggttgcaaa aacggaatat tcaaacaaca 7741 tattcccttc aagagtcctc aaatgcaggt ggctttaggg aaatgtcatg tgaaatctct 7801 gcgtggttgg gcactgagtg cccttggaac attttgggtt cagaaaacgt gtgaaactag 7861 ccgggtgagg tggctcttgc ctgtaatccc agcactttgg gaggatgagg tgggtggatg 7921 gcttgagctc aggagtttga gaccagcctg aacaatgtgg caaaacccca tctgtacaaa 7981 aaatacaaaa attagctggg tgtggtggtg cgcacccagg taatttttgt attttttata 8041 gagatgtggt cccagctgct tggttggggg aggctaaggt gggaggattg cttgagcctg 8101 ggaggtcaag gctgcagtga gctgtaattg agctactgca ctgcagcctc agcaataacc 8161 tgcggaaagg ggagatctgg ttacgtgaat gaaggcaaat gtatcatgtg tctacttcct 8221 ctcccagctc tgaacacaca gtccccaacc cacggaaggc ttgaattaca aagatccttc 8281 ataagacact tgggatttgg aacacatttt ctcataggaa tagtggcact tgcagttctg 8341 agtttccagg acagctcaca acacactgtt agtaccaaga attagcccag aagctcagca 8401 caaaatgaca ggattccaat ctgagctttg cccttactgg tcacatgacc ttggacaagt 8461 ggtccaacct ccctgaatct caggtaagaa tgtctgccct cctgcttcat ctgtggctga 8521 tgaagattga aaaggggtgt agatagaaaa gggggccgtg ggttctgaga gtattagatg 8581 atattgctct ctatactgaa ggaaaatgta gtaaagattc cttggaatcg cttatgttcc 8641 aactaggagc cccaaaccca ggtcaacaaa gcacagtttt cactctattt taacaactta 8701 actgggacat ggacctgcca gcagtgatat tttaaaaaat cgtggtaaaa tacccatttc 8761 ataaaattta ccattttaac cactttaaag tatacaattc agtggcatta agtacattca 8821 catgttataa gaccatcacc actatctatt tccagaacgt tttcatcatc ccaaagggaa 8881 acatcaagca cattaaggag tcccacccga tccctctctc ccccccagtc cctggtaact 8941 cctgctctgc tttctgtctg tatagattta cctattctgg atgcttcatg tagatgaaat 9001 catacaatat ttgccccatt gtgtctggct tctttcactt agtaaaatgt ttccaagctc 9061 catccatgtt gtaccatgtg tcagtacatc attcctttat tcctttttca tgtctgaata 9121 atagttcatc gtaggggtat accataattt gtccatccat ttacctgttg atggacactt 9181 gagttgtttc caccctttgg ctatggtaaa taatgctgct cttcttttgg gtgtggacct 9241 aggagtggaa ttgctggatc gtatggtacc tgtgtttaac ttgttgagga actgccattt 9301 tacattccca ccagcaacat atgaggttcc agtttctctg caacctcccc aacccttgtt 9361 attttccact tgttagttat ggccactcta gtgggtttga accagcatca attttggctg 9421 ttcatggcat cttgagatct gatgcagcca gtccaagatt tcattacact gctctgaaac 9481 actgagattg gcttttttgt gggctttttt ttcgtgtgtg tgtgtgtgtg tgtgtgtgtg 9541 tgtacctggc aaacttgatt cagccaggct gtatgaagga atgtcacctg tccaaagtac 9601 aagcgttgtg attacctggc acaccccact gtcaccgggt aagggaccac accagcaact 9661 gtaattggaa aaacacaagg caataactgc tgcatttggg agcctttcaa caaggaggcc 9721 tgtgtgcctt ctgttagaag gaactgaggc ttatgcctca gttcctcagt tcctcatgtt 9781 catgtgtttg gagggtgggg agaagaatct gacagtgttg gtgtcatctg ctgtctcagc 9841 tggcctcgtc ctgggctccg aacatgagac ccgtctggtg gcaaagctat ttaaagacta 9901 cagcagcgtg gtgcggccag tggaagacca ccgccaggtc gtggaggtca ccgtgggcct 9961 gcagctgata cagctcatca atgtggtgag acaagagcac tgggggcctg cccacacacc 10021 cacacctctc acccctgggt ttcctcccct gggtcccctc tctcccccat aaaaatgatc 10081 cttatttttt tttccaggat gaagtaaatc agatcgtgac aaccaatgtg cgtctgaaac 10141 aggtaactta gccagataat tgcatgtgtg tcgttttcat tcacactgaa attaaacctg 10201 ggcccagagg aaatcaatat gggtaacagg gatatatacc aaaatgttga aagtagatat 10261 tttgagatgg tgaaagcatg gatcctgttt ggttttggtt ttgctttttt ttaaacttta 10321 gggctttttc tgtgtgtgtt agtttgctag ggctgccata actgtgtggc ttaaacaaca 10381 gaaatttatc atctcatagc tctggaagat agaagtccaa agtctaggta ttggtagggt 10441 tggttccttc tgagggctgt gaggaagaat ctgtcctagg actctctctt cagcttgtag 10501 atgactgtct ttatgttcag atggcgttct tcttgtgtat gtgatacata tacatatgat 10561 atatatgaat atatatgtat atttaaatac atatatatct ttaaattccc cctttttatg 10621 aagacaccag tcatattgaa tgacagtcta ttttaatgac ttcattttaa cataattacc 10681 tctgtaaaga acctatctcc aaattaggtc acgttctgaa atactgggag ttagcgcttc 10741 agcatgaatt ttagggggac acaattgaac ccatagcatt gtgctttcca gctttactgc 10801 aatgggcaca tacaggtgga gtactccttt cccaaaatgc ttgggaccag aagtgtttca 10861 gattttggtt tttattttga aatatttgca tatacttacc agttaaactt cccaaatctg 10921 aaaatctgaa attcaaaatt ctccagtgaa catttcctga gtgtcatgtt ggtgctcaaa 10981 aagttttgga ttttggagca ttttggattt cggagcattt tggatttcag atttgggatc 11041 ctcaacctgt attacttttc ttttgagaca gagtctcact ctgtcgccca ggctggagtg 11101 caatggcgcg atctcggctc actgcaacct ctgcctccca ggttcaagcg attctcctgc 11161 ctcagcctcc caagtagctg ggactacagg cgcctaccac cacgcccggc taatttttgt 11221 gtttttaata gagacgaggt ttcactatgt tagccaggct ggtctcgaac tcctgacctc 11281 aggtgatcca cccacctcag cctcccaaag tgctgggatt acaggcatga gccaccatgc 11341 ccagacttta cttttataat gtagaaaaat atatggtact ttttaaaaat gatgttgcct 11401 gcttgagaaa aacgttcaca ctaggtcttt ctccttttct gtgggtggac agggtgacat 11461 ggtagatctg ccacgcccca gctgcgtgac tttgggagtt cctttgtttt ctcatctgca 11521 gaatgaggtc agtaatcacc ctcccctcac gggattgttg tgaggactaa atgagttaat 11581 ataggtaagt tgtttgaaac agtgtgagca cgtcgtcagt gctatatatt tgctgttctt 11641 atttactgaa gtgaaagcta aattctgaat ccaacttttc ttatggaagc acaatttctg 11701 tcaatactga attcccatgc acatcagggc tcttgataac cttagatttt agaaagtgtt 11761 tttggctttt taattagctg tatgtctttg tttctagcaa tgggtggatt acaacctaaa 11821 atggaatcca gatgactatg gcggtgtgaa aaaaattcac attccttcag aaaagatctg 11881 gcgcccagac cttgttctct ataacaagtg agcaaactgc atgggtggcg gagggtgctc 11941 ctggggcagg tggaataaag tgccctaata gaagggctgc gcgctcggaa tgcttctcac 12001 cactgctaat gttaaatcac ccaggatggt ggctcacacc tgtaaactca gcactttggg 12061 aggccaaggt gggaggattg cttgaggcca ggagtttgag atcagcctgg gcaacatagc 12121 aagacaacat ctctacaaaa ttaaaaaaaa aaatcactct aaaccaagag ccaagttgac 12181 gggctagggg tgccatatgg tgtctcatga cttaaagaga agggattact gcggccaaat 12241 tgaatccagg ctgagggtgg gggacatttg atccctgaga gcccctgaag catgtgtggc 12301 aactttccaa ggcacccaaa cgtcctatcg ctgaattcct tgcaatctag tgtcttccct 12361 accaaatatt tctgagcctc ctagggttgt cactcatcac atcctgaaca ccttctcgac 12421 atccactgct gctgttggcc tgggatgcct tcactgccca tccactgggc cccacgacag 12481 actgcatgtt gtgaaattat aatattattc aagacgttct ggtctaatga cacgttcatt 12541 agcatacgcc cttcatttgt caggaaatgc tcgtttcaaa aagcatcctt cccaggcagg 12601 agcatgcaac accggccggg aggatttatg gtctgacatt atacaacatg tgtcgggggt 12661 ccacaagctg tgtgtcctag cagacttagg gaaggtgaca gggctagtgg atgaaaacga 12721 taccttttaa ggcgggcctt ttcaagcttt gattttctgc cacacgtcat ccaattatac 12781 ctggggttca agcttgagcc aaattatccg atcatttgtg taatcttttt ggacaaatgg 12841 gctgatgaag tatctttcag tttctcttcc agtaggaatc tgagaagagc aattaaaatc 12901 ctttggttct tttgccaaac tcactcagga tcaccctggt gaggagagaa cactgttttg 12961 ttgcttattg ggagagacta agacaaccct atgactctct gccctttggg gctgctttgg 13021 gtgggtccaa tgccacatag ttttccaggt aaagagccca cttcaggccc aaggaaaaat 13081 caatgggaag aaaacctctt gatttatgac atgagggacc aacatatgcc atgatgtccc 13141 tgaaatccca ctgagacaga cctcatcctg cccattcaac acttattcta acaccctgcc 13201 ctctgctaaa tcccttgaac agactgctgt ttacgggaag agtaagtagt ccactgaata 13261 aggccggcag aaatggctta ttttgttttt ttagaacctc ccatggtttc tgtcttttta 13321 aaaataataa atcattgcca acatttgaaa accaagaaac atcacattaa aatctatttt 13381 ttagcctctc tagaaaaatc caacatttaa acttccagat tttttttttt ttttttgaga 13441 caaggtctct gctccattgc tcaggctgga gtgttgtggt gtgatcatag ctcattgcaa 13501 ccttgaactc tggggcttga gcaatcctct gcctcaacct cccaggtagc tggtactact 13561 ggtgtgtacc accatgcctc gctaattttt aaagaaaatt tagtagagat gaggtctcgc 13621 tgttggccag gctggtctca aactcatgga ctcaagcgat cttcctgcct tagtcttcca 13681 aagtgctggg attacaggca tgagccactg tacctggcaa agtctggcaa tttttgattt 13741 aaaaaaatct acgtttcact gggcgcaatg ctcacgcctg taatcccagc actttgggag 13801 gctgaggcgg gcagatcaca aggtcaggag atcaagacca tcctggctaa catggtgaaa 13861 ccccgtctct actaaaaata caaaaaatta gctgggcgtg gtggtgggcg cctgtagtcc 13921 cagctactcg ggagctgagg caggagaatg gtgggaaccc aggagacaga gcttgcagtg 13981 agccgatatc acgccactgc actccagcct gggcaacaga gggagactcc atctcaaaaa 14041 aaaaaaagaa aaaaaatcta agtttccagc ttccgaggaa gaatccaaat ctggcaagat 14101 tgggccttca ttcccacatg ggcgcctcag gggacactgc aaggtggcac cttcctgaca 14161 ggagagaggg gcgctctgtt cagcagtgtc agcctgcact cattcctcac ctgcctggcc 14221 ctggagatat ctgagtttgt gagtccaccc caatgagttc taaatcgttc tttaaaaagt 14281 agtaggccag tcaggcacgg tggctcactc ctgtaatcct agcactttga gaggccaagg 14341 caggcggatc acttgaggtc aggaattcag ggccagcctg gtcaacatgg tgaaacctag 14401 tttctattaa aaatacaaaa attagctggg tgtttggtgg gtgcctgtaa tctcagctac 14461 ctgggaggct gaggcaggag aattgcttga gcccgggagg tggaggttgc tgtgagccaa 14521 gattgcacca ttgcactcca gcctgggtga caaagcgaga ttccatctca aaaaaaaaaa 14581 aaaaaaaaaa gagtagtagg ccccttccct aacctgcttg tcgcagtaat gagtcgctgg 14641 aggtgtttta tgtaaaattc ctgtgttttt tttccccaac atagtacatc agggaggtga 14701 tagatgaaga ttaacattac aaatacttgt gagggctgga aaaataatct gggatgcagt 14761 ggacccatgt tacctgttat ttctttaaaa ctgtgggttc ccacattctt tcccagatac 14821 tcagattcag ggtttactta gagggtgtgc agaactctgt atttttaaca agcaccccag 14881 tgattcttat tatcaaatat ggggaacatt gcaatagata aaaagtgacg ctgcccgaaa 14941 cagagcttct ataattagca cctgaataat taacagctgt ctcctgttaa cgtccccaag 15001 cagaatggaa ggctcatctg tcacttggag ccattttcct cttttatccc aattgtagtg 15061 cagatggtga ctttgctatt gtcaagttca ccaaagtgct cctgcagtac actggccaca 15121 tcacgtggac acctccagcc atctttaaaa gctactgtga gatcatcgtc acccactttc 15181 cctttgatga acagaactgc agcatgaagc tgggcacctg gacctacgac ggctctgtcg 15241 tggccatcaa cccggtaggt ggtggccaca tatgataagg gtggtttcag gaaaattgtg 15301 attcgggtct ccaacttttc cttggacaat cataggctct cagtaccagt tagaacttag 15361 gaatcatcta gtttgatggt tcaagttgat tgggaaggga gaactaaatg ggagcttaaa 15421 ttaatttgct acacccaggc tcagtctcaa gaattctgat gtaatgggcc tggggtggcg 15481 gtagggcatc aatatgtttt aaagctccca ggtgacttga atgtgtagcc aaaatggaga 15541 atgctactag tccaaacccc cttatgtcat aggaaaggca tctaagaccc caaagcagta 15601 gtgtcccaca gtccctcctg ggtgtgtgac ccacagagct ggaatctgtg gccttgtcac 15661 tgctgattac aaaacgctgc ccctcatcag ggtgacctgc ctgggatttc caaacctcac 15721 ttcctttctc aggaaagcga ccagccagac ctgagcaact tcatggagag cggggagtgg 15781 gtgatcaagg agtcccgggg ctggaagcac tccgtgacct attcctgctg ccccgacacc 15841 ccctacctgg acatcaccta ccacttcgtc atgcagcgcc tgcccctcta cttcatcgtc 15901 aacgtcatca tcccctgcct gctcttctcc ttcttaactg gcctggtatt ctacctgccc 15961 acagactcag gtgggtgtgg ttgccatgac tgctgctgct gacgctgatg ggtctcgtgc 16021 tgctattttg gggaagccag aaataatcat gtgctaacaa acaggcagat cgacccgaac 16081 catcatcatt aggagggtgc atttgctgag tgggcgtgcg cagtggtgag agtcactgtg 16141 agtggagctc acagctgggg cagacacccc gagcggcagg gagttgaaca tgaccctaga 16201 gatgcacagt gtagcttagg ctggttaaag tacattaacc accaatacct atttgctgaa 16261 taccaactgt gtgcccagaa gtgtactggg taaggcatgt gatcccagac acttctcatg 16321 ccacttccac gatgaagtca ctttctatgt actgactaat cctggtcttg cccctttacc 16381 cactgctcac cacttgaaaa tagattttgc atatcttttt ttccagatgg tggcatcttc 16441 acacacaaga ccctacttcc caagtggctg ttctttctca catatcagcc tagacaactt 16501 acttacctcc tactgagtaa tcctatctgt gacataattt tatcaaacaa taacaatcca 16561 ccagaaagga ggaaagggta cccatctgcc tgccagcaag tcactattca taaacaactt 16621 atggcagaca agtttgaaaa aaagaaagat gctacagaca gacctcaagc ttatgacagg 16681 tagcaatttt tatcaaaatg actttaaaaa aaaaaaaacc acaaaatctt aaatccaact 16741 tgccaactag gaaaaaagat tattcattta ctcattcagt gaatatttgt tgaacaaata 16801 tgatgtggta gatagaccgc agagaataag acagaaagtg cctcacccct cagagtgcat 16861 gttccagtga ctgcatttgg ggtttcattt ttgtttttgt tttgagaccg ggtctcactc 16921 tgttgcccag gctgcagtac agtggcatga tcacggctca ctgcagcctc aacctcctga 16981 gctcaagtga ccctttcacc tcagcctcct gagtagctgg gactacaggc atgtgccacc 17041 acactcggct aatttttgta ttttttgtag aaacggggtt gcaccatgtt gccgaggcca 17101 gtctcgaact cctgggctca aagatctgcc tacctcggcc tcccaaagtg ctgggattac 17161 aggtgtgagc cactgtgcct gccctgcact tgtttttaaa caaataatca caaacacaat 17221 tctttcaact ttctaatcaa atgaaacttt tttacattaa aaaaataaat aaatagagat 17281 ggagtcttgc tatgttgccc aggctagtct cagactcctg gcctcaagtg atccccctgc 17341 cttggcctcc cggggtgtta ggattacagg catgatccac cgcaccaggc cctcaaatga 17401 aactttttaa aataaaaaca ctgtcggggc attatgggaa ctaacaagag tctctataaa 17461 cgttaaatga tttgtgcttg aaaagtgctt aggggccaga tgcagtggct cacacctgta 17521 atcccagcac tttcggaggc caaggcggat ggatcacttg aggtcaggag tttgagacca 17581 gcctggccaa catggtgaaa ccccatctct attaaaaata caaaaaatta gccaggtgtg 17641 gtggcacgtg cctgtaatcc caattacttg ggaggctgag gcaggagaat cgcttgaacc 17701 ctggaggcgg aggttgcagt gagctgagat ggcaccactg aactccagcc tgggcaacag 17761 agtgagactc cctcacaaaa aaaaaaagaa gaaaaaaaga aagaaaagaa agaaagaaaa 17821 aagaaaagca cttagcacaa aaattatgct tgataaatgt tggctattat tattatcatt 17881 attattaatc aacaaatttt atataagtgg acaaatattt tgtatttgta attgtattct 17941 ttttcacttt gaaaggtttt cctacccacc aggtagaatt gacaatttct tgtttgtttc 18001 cactctttat cgtatacata catacatatt ctatatatat tctagcatcc ggaagcagcc 18061 agtaggggac agcttcatca ttgaaagcag ggtaacacaa gggtttccag cagcaccaac 18121 agcaaggcca gcccagggaa agtccctccc agagcttctc tgctgcacct aaggtggtca 18181 agcctcacaa aactacctca gtgccattcg gcccctgacc ttcctgctgc caagtttgcc 18241 cagccaaaac tctcctgaga tcaaagggcc tgcagaaaag aggtgggggc tggggaaatc 18301 cctgctccct tagtatgcaa aaaaaacaaa acaagaaata agtgagaaga caaacttcct 18361 cttatatgaa aatgagacag cgagtggtgt gaaaccactg tatcagaaga tcactcagga 18421 cgtcaaggag aactccttag ccttccggat tttgtccttt tcttgggttt tggtcttaca 18481 gcttgctccc tcaataacag aaagatatgt gtacttctgg gctgcccatt catctgctgg 18541 gtaagaaata ggccaggggt ggttccgttt tatgaggttt aatgcatcct gctgcagaag 18601 ggaaatgcca caccgagtcc agcttgtcca cccagaactc ctttcagttc cctgggttcc 18661 accaagaatc agaaatctgg agcatgagat gaaatattgt tccgttttct gcttggcagc 18721 ctctaatgga aatgcttgcc actggctgct gtcagaaaag ttaaggtatg gtggttacat 18781 aggaaattct gcagaaaaaa atgctttgag atttcccaga ataatgcttt gagaacatgt 18841 cagtcacatt cctcttaccc ttgggtttca gtggtgaatt agtttgcttg ggctgccaca 18901 caaaacacca taggctgtga ggcttagata acagaaatgt aatttctcac agttctggag 18961 actggaattc caagatcaag gtgccagtag agttggtttc ttgtgaggcc tctctcggtt 19021 tgtaatggcc atcttcttcc tgtgtcccat ggccttccgt ctatgcatct gtgtcctaat 19081 tcctctcctt ataaggacac tagtcatact tgattactca ctaccccata tcacctcgtt 19141 ttcatttaat tacctcctta aagtccctgt cttcaaatac agtcacattc ttaggtccca 19201 ggactcagga cttccacata taaatggtgg ggtgggagga acactgcagc ccaacccaga 19261 tgggtagttg tgggattttt tttttttttt ttggtctttt caggggagaa gatgactctg 19321 agcatctctg tcttactgtc tttgactgtg ttccttctgg tcatcgtgga gctgatcccc 19381 tccacgtcca gtgctgtgcc cttgattgga aaatacatgc tgttcaccat ggtgttcgtc 19441 attgcctcca tcatcatcac tgtcatcgtc atcaacacac accaccgctc acccagcacc 19501 catgtcatgc ccaactgggt gcggaaggtg agtggggagg cccctgcaga cttcacacgg 19561 aggcacatct acaggcctcc ccttcgagga gccagtgggt ttctagctaa tacttggggc 19621 tatttaggaa ctaagttctc tttgggcttt agggaatttt tggaaggaac tttctttggc 19681 ctctttttag gaataaataa ctcctgtagc cttcccagag agaaaagaaa aacagaatta 19741 acaaagctca ttccaaattc aagtttaaag aatctctttg atcagagaag atgaacaaac 19801 ggctgctttt tattgaaatg ccgtgaaatt ctcgcgattt cttttgtatg ttttccaatc 19861 tgtgaacaga ctggcttatt ttttgctggt gaaatcatct gttgagaata gaatgaatag 19921 aatgagggct agagatggga gggttcctga tgagagaggg tcaaaaagtg agttttagtg 19981 aaggactagg tctgaaatag ttacgttatt gaatttaaaa atttaacatt tcaaatatgt 20041 ctttctttga caaaacttta cagagacact gaagtccagg atcttttgtc cagaatgtaa 20101 aatatttgtc aggaattgac aaaagaagct actgctcaca atgtactctt ttaagaggag 20161 agtaagagtc cctgtttctg taaaggctga tagatgactg ctggcaatac ctgtactgca 20221 gtttcttcag gaacaggaaa cagaagaaaa caatctagct gttttgtggg atatatttga 20281 agtggagggg ccccttcttt aaccatttga tcctggtgac acattgctaa ggcattttcc 20341 atacctgtag gggatcctga cgcttttaag ctcattggtg gccccaggtc gatgactgca 20401 catgggctcc ctccagtggc gaacttctca cattacagaa tcatcactgt taaccatagt 20461 catttcacag gacccgggat acagagggat ctttgaaaaa atctagtata gttcttttgt 20521 tttaaggaca aggaggctga agcccagaaa aactgaatga cttaccccaa atcacattga 20581 taattcaaag acagagtttt atgcttgcct cctggacaat aattctcatg catggatttc 20641 ttttttatgt taggttttta tcgacactat cccaaatatc atgtttttct ccacaatgaa 20701 aagaccatcc agagaaaagc aagacaaaaa gatttttaca gaagacattg atatctctga 20761 catttctgga aagccagggc ctccacccat gggcttccac tctcccctga tcaaacaccc 20821 cgaggtgaaa agtgccatcg agggcatcaa gtacatcgca gagaccatga agtcagacca 20881 ggagtctaac aatgtaagct tcgtggcttg aaattcatgc ctctgggttt aaatggtcaa 20941 atgtatgagc acaggtggtg agtctgactt aacaagtagg tggcatacaa caggcagcta 21001 ctgacctaag atgaaccctg gtgaccgcct ctagaccacc ttagtaagtt atcactttgt 21061 aaataatcta ttcaaaaaat aaagacgatg ccagccaagg gatgggagga ctttgagatc 21121 tacaaattga agggcccata gttgatgcaa agcacaaacg ttgtgagtcc agaaaccacc 21181 ttagggagac tctgtctaac attttcctct ctcccaggcg gcggcagagt ggaagtacgt 21241 tgcaatggtg atggaccaca tactcctcgg agtcttcatg cttgtttgca tcatcggaac 21301 cctagccgtg tttgcaggtc gactcattga attaaatcag caaggatgag cagaaaatga 21361 gctgagctta gctctgccct ggaacctacc agagcagaga agggcaggag aggaagattt 21421 gtctacttgc tccactcgca cttatcaaac gtgttatatt ccatacttat tattgatgat 21481 aagatttacc tttatgtaag tttatggcct tgaagtgttt tcatattgct tctcccttta 21541 gttctgctgt ctccctgaag agtgaaccct ctttagtaaa tgaaactaat cactaaaaaa 21601 agtgttcatt tccagtgtct ggaagagttt ttgccaggat aaccgaggtt ttctgttgca 21661 ttgtcattgc tgttatattt atatatttac ttattttgtc taaccacgag accactaggg 21721 agttgctgat gttctaaatg aagtgtattc tttgcttaag agtcagtttt gtacctacta 21781 agaaaacccc atctaccagt cctaaagaga taaggcattt gatttggaga gagaggaagc 21841 agtagaaatg aaataaacta aaatgcaaac tgcatcaaaa atccatgggt ttttttgttt 21901 gtttgattgt tttttgagac agggtcttac tcttatcacc caggctagag tgcagtggcc 21961 cgatctcgtc tcactgcagc ctccacttgc cagactcagg tgattcttct acctcagcct 22021 cccggggtag ctgagactac aggtgcatgt caccacaccc aactaacttt tgtatttttt 22081 gcagagacag ggttttgcca cgttgcccag gctggtcttg aactcctggg ctcaagtgat 22141 ccacccatct tggcctcccg aagtgctggg attacagctg tgagccactg cccttgacaa 22201 aaaaaatcca tgttttaaag cagctttcta gacctgagaa gtcagagaag gtttaccagt 22261 ctcatatggc acctgggctt gataagggtc tgaaaggaaa caagtccaaa caatagggcc 22321 taggcactac ggaaattgtc ttgcctgtat gggtttactt catcatcatc cccttcataa 22381 aatcctagaa tgtccctatt ttacaaatga gaaaattaaa tttcagggaa atcctgtaat 22441 gtccctattt tccaaatgag aaaattgaat ttcagggagg ttaagttctt tgctcaaact 22501 agaagaactg ggatttgaat ccagactttg agattccaaa gcaactccag gctgggtcag 22561 ttcatctgtt cactggctct cccagccacc cctggctcca tctaggccat cctgtaactc 22621 tgctcagtgt tgtcaagaat ttcagtctta gcaaaaaacc atctttctgt cttcccaatt 22681 aaaatttgtg ccttccaccc accaccagcc cttattccaa tcatgtttga ggttcaagtc 22741 ctataaatga aaccagaaat gtattacgca tcatcaccat ttctaaaatt ctgaagaagt 22801 aagtagaaga gaaattgatt tcttttcaca ttgtaaactt taatccacag tatagtttgc 22861 ccaagaacta gaaactgtgc agctacgggc caggcttagt tgatggcctc caaatcacca 22921 taacccaact gtatttgtca gggttctcca gaaacacaca accaataaga tatgtgtgtg 22981 tatcacagtt tctagttgtt gggtaaacta tattatggat tacaatttac aagatgaaaa 23041 gaaataatat atatgagaaa tcataaatat atctatgagg ctgagaagtc ccacaacagg 23101 ttgtctgcaa gctgggattc cagtagcatg gctcagtcca aatctgaagg cttcagaacc 23161 aaaaaagccc atggtataat tctcagtcca aggctgaagg cccaagaacc cagagggaac 23221 atcagtctaa gtcctggagt ccaaaagcca gagagcctgg agttctgatg tccaagggca 23281 agaggaggag ggtgtcccat ctccaagaag agagatatga gtttgccttt cccctgcctt 23341 tttgtgttct atctgggccc ccagccaaat ggatggtgcc cacccacact gaggacagat 23401 ctcccccact cagtctgact gacacatcag actcctgtgg aaacaaatac acccagagat 23461 gatgttttac cagttctcta gctatgcctt aatcctgtca agtcaacacc taaaattaac 23521 catcacaaac ccaccccttg tcaacttggc acccataccc atctccttaa accatacttg 23581 gtctccaatt aaagacaata acaaggtaat agttcaccca gcgtgatgca gctatcctgc 23641 attcaaccaa aaatgcatta acccctgccc cagaaaggag gtcaagtcct tgactgatgt 23701 ttactcttcc catgagatcc cgtaatttaa atactatgat gtaaaattaa caatacgtca 23761 atacggatat aaagtcagta tcttatgtta cataagagag aggaatgaaa acaaagatat 23821 ttgcttaata tatgtatata tacatacaaa tgtattttta acaaatggga ggaaacactc 23881 a //