Triadin (TRDN) - coding DNA reference sequence

(used for mutation description)

(last modified May 24, 2012)


This file was created to facilitate the description of sequence variants in the TRDN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_030438.1, covering TRDN transcript NM_006073.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           ctctagagtgccaaaaaa       c.-301

 .         .         .         .         .         .                g.5078
 gaaaaaaaaaagtgctgaagagtcctagggagatgaggctatttttgtttgaagctgata       c.-241

 .         .         .         .         .         .                g.5138
 cttctagctgagccacaagtgctgcttggaaagggcttaggttgtttccagggggagaac       c.-181

 .         .         .         .         .         .                g.5198
 tctgcagaggagaggcaaagttcaacaggacaacaaagaagcagcagaaacagccaggaa       c.-121

 .         .         .         .         .         .                g.5258
 aacgaagagcccccaggttttgacacagaaccctccaccagagttctcaaatccccaaat       c.-61

 .         .         .         .         .         .                g.5318
 actctgcaaagtgcaacttgacgggaacttttcaactgacttttacttttgacgaccacc       c.-1

          .         .   | 02     .         .         .         .    g.70999
 ATGACTGAGATCACTGCTGAAG | GAAATGCATCTACAACCACAACTGTGATAGACAGCAAA    c.60
 M  T  E  I  T  A  E  G |   N  A  S  T  T  T  T  V  I  D  S  K      p.20

          .         .         .         .         .         .       g.71059
 AATGGATCTGTGCCCAAATCCCCCGGAAAAGTGCTGAAGAGGACAGTCACAGAAGACATA       c.120
 N  G  S  V  P  K  S  P  G  K  V  L  K  R  T  V  T  E  D  I         p.40

          .         .         .         .         .         .       g.71119
 GTGACGACGTTCAGCTCCCCTGCAGCCTGGCTTCTGGTCATTGCCCTGATAATCACGTGG       c.180
 V  T  T  F  S  S  P  A  A  W  L  L  V  I  A  L  I  I  T  W         p.60

          .         .         .         .         .   | 03     .    g.93489
 TCAGCTGTTGCCATCGTTATGTTTGATTTAGTGGATTACAAAAACTTTTCAG | CAAGCTCT    c.240
 S  A  V  A  I  V  M  F  D  L  V  D  Y  K  N  F  S  A |   S  S      p.80

          .         .         .         .         .         .       g.93549
 ATTGCCAAGATTGGCTCAGATCCTTTAAAACTGGTACGTGATGCTATGGAGGAAACCACG       c.300
 I  A  K  I  G  S  D  P  L  K  L  V  R  D  A  M  E  E  T  T         p.100

          .         .         .         .         .         .       g.93609
 GACTGGATCTATGGCTTCTTTTCTTTGTTATCTGACATCATCTCATCTGAAGATGAAGAA       c.360
 D  W  I  Y  G  F  F  S  L  L  S  D  I  I  S  S  E  D  E  E         p.120

          .         .         .  | 04      .         .         .    g.94750
 GATGATGATGGTGACGAAGATACTGATAAAG | GAGAAATAGATGAGCCTCCCTTGAGAAAA    c.420
 D  D  D  G  D  E  D  T  D  K  G |   E  I  D  E  P  P  L  R  K      p.140

      | 05   .         .         .         .         .         .    g.111584
 AAAG | AAATACACAAAGATAAGACTGAAAAACAAGAGAAACCTGAAAGGAAAATACAAACT    c.480
 K  E |   I  H  K  D  K  T  E  K  Q  E  K  P  E  R  K  I  Q  T      p.160

      | 06   .         .         .         .         .         .    g.125943
 AAAG | TTACACACAAAGAAAAAGAAAAAGGAAAAGAAAAAGTAAGAGAAAAAGAAAAACCT    c.540
 K  V |   T  H  K  E  K  E  K  G  K  E  K  V  R  E  K  E  K  P      p.180

          . | 07       .         .         .         .         .    g.129781
 GAAAAGAAAG | CAACTCACAAGGAAAAAATTGAGAAAAAAGAAAAACCAGAAACAAAGACA    c.600
 E  K  K  A |   T  H  K  E  K  I  E  K  K  E  K  P  E  T  K  T      p.200

          . | 08       .         .         .         .         .    g.138242
 CTGGCGAAAG | AACAGAAGAAAGCTAAGACTGCAGAAAAGAGTGAAGAAAAGACTAAAAAG    c.660
 L  A  K  E |   Q  K  K  A  K  T  A  E  K  S  E  E  K  T  K  K      p.220

          .         .         .         .         .         .       g.138302
 GAAGTGAAAGGTGGAAAACAGGAGAAAGTGAAGCAAACAGCTGCAAAAGTAAAAGAAGTA       c.720
 E  V  K  G  G  K  Q  E  K  V  K  Q  T  A  A  K  V  K  E  V         p.240

          .         .         .         .         .         .       g.138362
 CAGAAAACACCATCAAAACCCAAAGAAAAGGAGGACAAAGAGAAAGCAGCTGTGTCAAAG       c.780
 Q  K  T  P  S  K  P  K  E  K  E  D  K  E  K  A  A  V  S  K         p.260

          .    | 09    .         .         .         .         .    g.144888
 CATGAACAGAAAG | ATCAGTATGCATTCTGTCGATATATGATTGACATATTTGTCCATGGG    c.840
 H  E  Q  K  D |   Q  Y  A  F  C  R  Y  M  I  D  I  F  V  H  G      p.280

          .    | 10    .         .         .         .         .    g.177157
 GATTTAAAACCAG | GACAAAGCCCAGCCATTCCACCTCCCTTACCGACAGAACAAGCTTCC    c.900
 D  L  K  P  G |   Q  S  P  A  I  P  P  P  L  P  T  E  Q  A  S      p.300

          .         .         .  | 11      .         .         .    g.203119
 AGACCCACTCCGGCATCACCTGCCCTTGAAG | AAAAAGAAGGGGAAAAGAAGAAGGCTGAG    c.960
 R  P  T  P  A  S  P  A  L  E  E |   K  E  G  E  K  K  K  A  E      p.320

          .         .         .  | 12      .         .         .    g.204000
 AAGAAAGTTACTTCTGAAACAAAAAAGAAAG | AAAAAGAAGATATCAAAAAGAAAAGTGAG    c.1020
 K  K  V  T  S  E  T  K  K  K  E |   K  E  D  I  K  K  K  S  E      p.340

          .         .         .  | 13      .         .         .    g.248445
 AAGGAAACTGCCATTGATGTGGAAAAAAAAG | AGCCGGGAAAAGCTTCTGAAACCAAACAA    c.1080
 K  E  T  A  I  D  V  E  K  K  E |   P  G  K  A  S  E  T  K  Q      p.360

          .         .      | 14  .         .         .      | 15  . g.259951
 GGGACTGTAAAAATTGCAGCACAAG | CAGCAGCTAAGAAGGATGAAAAGAAGGAAG | ATTCC c.1140
 G  T  V  K  I  A  A  Q  A |   A  A  K  K  D  E  K  K  E  D |   S   p.380

          .         .      | 16  .         .       | 17 .         . g.264209
 AAGAAAACAAAAAAACCTGCAGAAG | TAGAACAACCCAAGGGAAAAA | AACAGGAAAAGAAA c.1200
 K  K  T  K  K  P  A  E  V |   E  Q  P  K  G  K  K |   Q  E  K  K   p.400

          .          | 18        .         .       | 19 .         . g.266476
 GAAAAACATGTGGAACCAG | CAAAGTCACCAAAGAAAGAACACTCAG | TTCCAAGTGACAAA c.1260
 E  K  H  V  E  P  A |   K  S  P  K  K  E  H  S  V |   P  S  D  K   p.420

          .    | 20    .         .         .         .         .    g.275958
 CAAGTAAAAGCAA | AAACTGAACGAGCCAAAGAGGAGATTGGTGCGGTTTCAATTAAAAAA    c.1320
 Q  V  K  A  K |   T  E  R  A  K  E  E  I  G  A  V  S  I  K  K      p.440

   | 21      .         .         .         .          | 22        . g.304435
 G | CTGTACCTGGAAAGAAGGAAGAGAAAACAACCAAGACAGTGGAGCAAG | AAATTAGAAAA c.1380
 A |   V  P  G  K  K  E  E  K  T  T  K  T  V  E  Q  E |   I  R  K   p.460

          .         .         .         . | 23       .         .    g.310184
 GAAAAATCTGGGAAGACTTCTTCAATTCTGAAAGATAAAG | AACCTATTAAAGGGAAAGAA    c.1440
 E  K  S  G  K  T  S  S  I  L  K  D  K  E |   P  I  K  G  K  E      p.480

          .         .         .  | 24      .         .         .    g.325627
 GAGAAAGTTCCAGCTTCCCTAAAGGAAAAAG | AACCTGAAACTAAAAAAGATGAAAAGATG    c.1500
 E  K  V  P  A  S  L  K  E  K  E |   P  E  T  K  K  D  E  K  M      p.500

          . | 25       .         .        | 26.         .         . g.363769
 TCCAAAGCAG | GCAAAGAAGTCAAGCCTAAACCTCCAC | AACTACAAGGAAAAAAGGAAGAG c.1560
 S  K  A  G |   K  E  V  K  P  K  P  P  Q |   L  Q  G  K  K  E  E   p.520

         | 27.         .         .        | 28.         .         . g.368753
 AAGCCAG | AGCCCCAAATTAAAAAAGAAGCAAAACCAG | CTATATCTGAAAAAGTGCAAATA c.1620
 K  P  E |   P  Q  I  K  K  E  A  K  P  A |   I  S  E  K  V  Q  I   p.540

      | 29   .         .         .         .         .   | 30     . g.370915
 CACA | AACAAGACATAGTGAAACCAGAAAAGACTGTTTCTCATGGTAAACCAG | AAGAAAAA c.1680
 H  K |   Q  D  I  V  K  P  E  K  T  V  S  H  G  K  P  E |   E  K   p.560

          .         .         .         . | 31       .         | 32 g.374344
 GTTCTCAAGCAGGTAAAAGCTGTCACAATAGAAAAAACAG | CCAAGCCCAAACCAACAA | AA c.1740
 V  L  K  Q  V  K  A  V  T  I  E  K  T  A |   K  P  K  P  T  K |    p.580

          .         .         .         .    | 33    .         .    g.376772
 AAAGCTGAACATCGAGAAAGAGAACCTCCATCTATAAAAACAG | ACAAACCAAAACCAACT    c.1800
 K  A  E  H  R  E  R  E  P  P  S  I  K  T  D |   K  P  K  P  T      p.600

      | 34   .         .         .  | 35      .         .         . g.382460
 CCAA | AAGGAACATCAGAAGTCACAGAATCAG | GAAAGAAGAAAACTGAAATATCTGAAAAA c.1860
 P  K |   G  T  S  E  V  T  E  S  G |   K  K  K  T  E  I  S  E  K   p.620

          . | 36       .         .         .       | 37 .         . g.386982
 GAAAGTAAAG | AAAAAGCAGACATGAAGCATCTTAGAGAAGAAAAAG | TCTCAACAAGAAAA c.1920
 E  S  K  E |   K  A  D  M  K  H  L  R  E  E  K  V |   S  T  R  K   p.640

          .         .         .  | 38      .         .      | 39  . g.417967
 GAAAGTCTTCAATTACACAATGTGACAAAAG | CAGAAAAACCTGCAAGAGTATCAA | AAGAT c.1980
 E  S  L  Q  L  H  N  V  T  K  A |   E  K  P  A  R  V  S  K |   D   p.660

          .         .         .     | 40   .         .         .    g.420597
 GTTGAAGATGTACCAGCTTCAAAGAAAGCTAAAG | AAGGAACTGAAGATGTGTCTCCCACA    c.2040
 V  E  D  V  P  A  S  K  K  A  K  E |   G  T  E  D  V  S  P  T      p.680

          . | 41       .         .         .         .         .    g.423403
 AAGCAGAAAA | GTCCCATCAGTTTCTTCCAGTGTGTCTACTTGGATGGGTACAATGGCTAT    c.2100
 K  Q  K  S |   P  I  S  F  F  Q  C  V  Y  L  D  G  Y  N  G  Y      p.700

          .         .         .         .         .         .       g.423463
 GGATTTCAGTTTCCTTTCACTCCTGCAGACCGCCCTGGAGAGAGCTCTGGTCAAGCAAAT       c.2160
 G  F  Q  F  P  F  T  P  A  D  R  P  G  E  S  S  G  Q  A  N         p.720

          .         .         .                                     g.423493
 TCTCCAGGACAGAAGCAACAAGGACAGTAA                                     c.2190
 S  P  G  Q  K  Q  Q  G  Q  X                                       p.729

          .         .         .         .         .         .       g.423553
 acacacatgtatgacccttacaagtgctttaagattttaaaaatgtgatgttttgtccac       c.*60

          .         .         .         .         .         .       g.423613
 agtagttcaggcaattaagaatatgcaacccagagaatttctgtgaaaacattttgctct       c.*120

          .         .         .         .         .         .       g.423673
 ttggcctggtgtggacggaaagggtggccaaatggattgagtgatgagcagacatgttta       c.*180

          .         .         .         .         .         .       g.423733
 agggtctaagtctcaagaatctgttatgtgtgtttgctgcggtgggagggggtgcttgta       c.*240

          .         .         .         .         .         .       g.423793
 tttatcttatttccagtcactataaggttgtacacaaactaatttaaagtttacttaata       c.*300

          .         .         .         .         .         .       g.423853
 atggtatctttaaaataattgacacaattgcaaaatgaattcctggcttcagttagctat       c.*360

          .         .         .         .         .         .       g.423913
 tatttttttaatgacaacatagactgtgctctaagtttaaaagatggggaagcttatata       c.*420

          .         .         .         .         .         .       g.423973
 aaagtgacccttttgcatcatatgggtatctaaacttaatttacccaataagttgatgct       c.*480

          .         .         .         .         .         .       g.424033
 taatgattttattttatttttgtctatttctattttagttgtggctttgctctaagaatg       c.*540

          .         .         .         .         .         .       g.424093
 ggtaatagttgtactacagactgctataaatttcttgtgatactcttttagagctcaaaa       c.*600

          .         .         .         .         .         .       g.424153
 tatctctgagctttagacatggtaaggtggagagtaaatgcttgataaatctttaagata       c.*660

          .         .         .         .         .         .       g.424213
 tgtcttgaatgataattaggacattcagtccagtggaaatacaccattcaattagtcagg       c.*720

          .         .         .         .         .         .       g.424273
 tctggtgaatcgtttgtttaaaatattagcaaatgagatgtggaattctgaaatttctcc       c.*780

          .         .         .         .         .         .       g.424333
 agactgtgtcttaataaaaatgtcacctgggtgaaattttagatcaatcactaaatttgg       c.*840

          .         .         .         .         .         .       g.424393
 gtgacaaatataaaaatattttcatttcactttaatacattctttctgtgaagtaaaatg       c.*900

          .         .         .         .         .         .       g.424453
 tttttctttctcataatggcaaaatatgaatgccatcaaagtttaaggaattcattttag       c.*960

          .         .         .         .         .         .       g.424513
 ccttaaatgccttcgtgagatgtcttacttgtattttaggtaactggtcatcagtgccaa       c.*1020

          .         .         .         .         .         .       g.424573
 tgacatggataacaatttttaatctactcgacagtgcatccctgggaatgactgttatgt       c.*1080

          .         .         .         .         .         .       g.424633
 ttttgtcatattcctggtaatataaatactcgtgttctttactacattgtttttatcaac       c.*1140

          .         .         .         .         .         .       g.424693
 tctaaaagtcatgcctctgtgacctttatcatgtttacaattgcaactgaacttatgaca       c.*1200

          .         .         .         .         .         .       g.424753
 aattaactcaggaaataaattgagttatcctttctagcattgtaattaccatcagcaagg       c.*1260

          .         .         .         .         .         .       g.424813
 cctgagatagccagagccaatactagccaagtgatttattttcaaggattgccactaact       c.*1320

          .         .         .         .         .         .       g.424873
 acggttctttaggaccaagatataaaacagtcactaaaaatcattaggctaggtatcagt       c.*1380

          .         .         .         .         .         .       g.424933
 aatacattcattactaataatgcatttttggagacttttgtgaaagaagttggtctctgc       c.*1440

          .         .         .         .         .         .       g.424993
 caaaagctggtggaccacattcacaccacgaaagccagtgtcacatgaaccagattaatg       c.*1500

          .         .         .         .         .         .       g.425053
 actctctttatggggtatgtgggacatcctggaagtgtataatttcaggaatgaccagac       c.*1560

          .         .         .         .         .         .       g.425113
 aataccatcttgcaaagccccttcaggtgacaatctaaacttgtgggtaggagagtgcat       c.*1620

          .         .         .         .         .         .       g.425173
 aaagtttattgctcaactgctcctccagcctgctgaatttactgagtaaagaaatagcaa       c.*1680

          .         .         .         .         .         .       g.425233
 atatgatagatgttttagatttcatagaacagaatggtttgtccattaattctttcattc       c.*1740

          .         .         .         .         .         .       g.425293
 aatgactgtttattgaatacctactcttttagggcgctgtgttaggtgctgtattgtaca       c.*1800

          .         .         .         .         .         .       g.425353
 agaaaaatataataaattagattcccagcgctattctgacatagtgaatgaccttgaaaa       c.*1860

          .         .         .         .         .         .       g.425413
 atttactaaacatactatgtttgtttctccatgagtaaaatagggatatagggacaaaca       c.*1920

          .         .         .         .         .         .       g.425473
 gtctaatatctcatagaaataccatggagacaaataaaatattttaatataaatatgata       c.*1980

          .         .         .         .         .         .       g.425533
 ttaaagtaaatttctgaagtaatacttttgggtatggcactagtttttcctctgactatt       c.*2040

          .         .         .         .         .         .       g.425593
 ttactgtttctttcactctcaatataaaaactatttgataagataaaacgatatatttta       c.*2100

          .         .         .         .         .         .       g.425653
 ttgtaattagaatttagacaaatcagctataatgtaaaaatgttaataataattacgttt       c.*2160

          .         .         .         .         .         .       g.425713
 tatctgattaaagttacaatgatcatagcactttaaaaatattatctgaactgtcatttg       c.*2220

          .         .         .         .                           g.425755
 tttatatattaccgtctaataaaatagttatagatcttccaa                         c.*2262

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Triadin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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