chaperonin containing TCP1, subunit 5 (epsilon) (CCT5) - coding DNA reference sequence

(used for mutation description)

(last modified November 3, 2012)


This file was created to facilitate the description of sequence variants in the CCT5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012160.1, covering CCT5 transcript NM_012073.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          gattccagaagatactgtctggcgtgaaattagtctcagtagaaacataag       c.-121

 .         .         .         .         .         .                g.5111
 tcccgcgcgtcttgtgctgcgcgtgcgcaagcttttgggccctcccgagaaagggaagtg       c.-61

 .         .         .         .         .         .                g.5171
 cattctcgcttccgtagcggtctccgccggttggggggaagtaattccggttgttgcacc       c.-1

          .         .         .         .         .         .       g.5231
 ATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAG       c.60
 M  A  S  M  G  T  L  A  F  D  E  Y  G  R  P  F  L  I  I  K         p.20

          .         .         .         .      | 02  .         .    g.8990
 GATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAG | TCTCATATAATGGCA    c.120
 D  Q  D  R  K  S  R  L  M  G  L  E  A  L  K   | S  H  I  M  A      p.40

          .         .         .         .       | 03 .         .    g.9518
 GCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATG | GGCTTGATAAGATG    c.180
 A  K  A  V  A  N  T  M  R  T  S  L  G  P  N  G |   L  D  K  M      p.60

          .         .         .         .         .         .       g.9578
 ATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATG       c.240
 M  V  D  K  D  G  D  V  T  V  T  N  D  G  A  T  I  L  S  M         p.80

          .         .         .         .         .         .       g.9638
 ATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGAT       c.300
 M  D  V  D  H  Q  I  A  K  L  M  V  E  L  S  K  S  Q  D  D         p.100

          .         .         .  | 04      .         .         .    g.10814
 GAAATTGGAGATGGAACCACAGGAGTGGTTG | TCCTGGCTGGTGCCTTGTTAGAAGAAGCG    c.360
 E  I  G  D  G  T  T  G  V  V  V |   L  A  G  A  L  L  E  E  A      p.120

          .         .         .         .         .         .       g.10874
 GAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCT       c.420
 E  Q  L  L  D  R  G  I  H  P  I  R  I  A  D  G  Y  E  Q  A         p.140

          .         .         .         .         .         .       g.10934
 GCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAG       c.480
 A  R  V  A  I  E  H  L  D  K  I  S  D  S  V  L  V  D  I  K         p.160

          .         .         .         .         . | 05       .    g.12951
 GACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGT | GGTCAACAGT    c.540
 D  T  E  P  L  I  Q  T  A  K  T  T  L  G  S  K  V  |  V  N  S      p.180

          .         .         .         .         .         .       g.13011
 TGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAG       c.600
 C  H  R  Q  M  A  E  I  A  V  N  A  V  L  T  V  A  D  M  E         p.200

          .         .         .         .         .         .       g.13071
 CGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAG       c.660
 R  R  D  V  D  F  E  L  I  K  V  E  G  K  V  G  G  R  L  E         p.220

          .         .         .         .         .         .       g.13131
 GACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCA       c.720
 D  T  K  L  I  K  G  V  I  V  D  K  D  F  S  H  P  Q  M  P         p.240

     | 06    .         .         .         .         .         .    g.13273
 AAA | AAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCA    c.780
 K   | K  V  E  D  A  K  I  A  I  L  T  C  P  F  E  P  P  K  P      p.260

          .         .         .         .         .         .       g.13333
 AAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATAC       c.840
 K  T  K  H  K  L  D  V  T  S  V  E  D  Y  K  A  L  Q  K  Y         p.280

          .         .         .    | 07    .         .         .    g.15649
 GAAAAGGAGAAATTTGAAGAGATGATTCAACAA | ATTAAAGAGACTGGTGCTAACCTAGCA    c.900
 E  K  E  K  F  E  E  M  I  Q  Q   | I  K  E  T  G  A  N  L  A      p.300

          .         .         .         .         .         .       g.15709
 ATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCT       c.960
 I  C  Q  W  G  F  D  D  E  A  N  H  L  L  L  Q  N  N  L  P         p.320

          .         .         .    | 08    .         .         .    g.16417
 GCGGTTCGCTGGGTAGGAGGACCTGAAATTGAG | CTGATTGCCATCGCAACAGGAGGGCGG    c.1020
 A  V  R  W  V  G  G  P  E  I  E   | L  I  A  I  A  T  G  G  R      p.340

          .         .         .         .         .         .       g.16477
 ATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAG       c.1080
 I  V  P  R  F  S  E  L  T  A  E  K  L  G  F  A  G  L  V  Q         p.360

          .         .         .         .         .         .       g.16537
 GAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCC       c.1140
 E  I  S  F  G  T  T  K  D  K  M  L  V  I  E  Q  C  K  N  S         p.380

          .         .         .          | 09        .         .    g.17332
 AGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATG | ATCATTGAGGAGGCGAAACGA    c.1200
 R  A  V  T  I  F  I  R  G  G  N  K  M   | I  I  E  E  A  K  R      p.400

          .         .         .         .         .         .       g.17392
 TCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTAT       c.1260
 S  L  H  D  A  L  C  V  I  R  N  L  I  R  D  N  R  V  V  Y         p.420

          .         .         .         .         .        | 10.    g.17967
 GGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAG | TGC    c.1320
 G  G  G  A  A  E  I  S  C  A  L  A  V  S  Q  E  A  D  K   | C      p.440

          .         .         .         .         .         .       g.18027
 CCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATG       c.1380
 P  T  L  E  Q  Y  A  M  R  A  F  A  D  A  L  E  V  I  P  M         p.460

          .         .         .         .         .         .       g.18087
 GCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGA       c.1440
 A  L  S  E  N  S  G  M  N  P  I  Q  T  M  T  E  V  R  A  R         p.480

          .         .         .         .         .         | 11    g.19488
 CAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATG | AT    c.1500
 Q  V  K  E  M  N  P  A  L  G  I  D  C  L  H  K  G  T  N  D |       p.500

          .         .         .         .         .         .       g.19548
 ATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCA       c.1560
 M  K  Q  Q  H  V  I  E  T  L  I  G  K  K  Q  Q  I  S  L  A         p.520

          .         .         .         .         .         .       g.19608
 ACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAA       c.1620
 T  Q  M  V  R  M  I  L  K  I  D  D  I  R  K  P  G  E  S  E         p.540

                                                                    g.19614
 GAATGA                                                             c.1626
 E  X                                                               p.541

          .         .         .         .         .         .       g.19674
 agacattgagaaaactatgtagcaagatccacttctgtgattaagtaaatggatgtctcg       c.*60

          .         .         .         .         .         .       g.19734
 tgatgcatctacagttatttattgttacatccttttccagacactgtagatgctataata       c.*120

          .         .         .         .         .         .       g.19794
 aaaatagctgtttggtaaccatagtttcacttgttcaaagctgtgtaatcgtgggggtac       c.*180

          .         .         .         .         .         .       g.19854
 catctcaactgcttttgtattcattgtattaaaagaatctgtttaaacaacctttatctt       c.*240

          .         .         .         .         .         .       g.19914
 ctcttcgggtttaagaaacgtttattgtaacagtaattaaatgctgccttaattgaaggg       c.*300

          .         .         .         .         .         .       g.19974
 gtttgggtggatttttttttctcaaaataagctgtagggactattttaacagcttaaaca       c.*360

          .         .         .         .         .         .       g.20034
 ggagctctcaagatgcactttcatattgagaggaatatgggcttgatcctcttcctatct       c.*420

          .         .         .         .         .         .       g.20094
 aaatgggtgggccatttgattgtagagggtccaccacagaattatgggatgccttaagtg       c.*480

          .         .         .         .         .         .       g.20154
 ctgttactaggttgctcacagcctaacctggcgtgttgtttagggctgatggagacccat       c.*540

          .         .         .         .         .         .       g.20214
 gtgagcctttgctttcctctggccccggccccaccctgaacacagctcatacacagaatc       c.*600

          .         .         .         .         .         .       g.20274
 aggaccagcatgtgcagagctggccaccagcacaggcttagggcagttcagaacccactt       c.*660

          .         .         .         .         .         .       g.20334
 gtttccctatcagagggacacagtgaagtggaggttaaagtaaattacaggaaataaggg       c.*720

          .         .         .         .         .         .       g.20394
 agaaatcttgcagttaccatgttcagatagagtgactgaaattaattgtacttactaaag       c.*780

          .         .         .         .         .         .       g.20454
 tattaactagctaacagtgatgggccaagacgctccgagaactctaccgggattgtctgt       c.*840

          .         .         .         .         .         .       g.20514
 tctgacaacccagtgaggcagatacactttcttactgctcacatcttacaggtgagtact       c.*900

          .         .         .         .         .         .       g.20574
 cataattggccagcatctcaccaccagcaagtagtagggccaggtcaatcccaggcagtc       c.*960

          .         .         .         .         .         .       g.20634
 tgaccccagagtggcccagctcatcccctactctgttatttgcttgttaatgattctcta       c.*1020

          .         .         .         .         .         .       g.20694
 gattttctaaaataatgtttcttagcattgtgatgataaagctcatgatgaactttatca       c.*1080

          .         .         .         .         .         .       g.20754
 ctagttatgccaccttaactagtcagatttcctagaattaggaaatggtgactcttgtct       c.*1140

          .         .         .         .         .         .       g.20814
 aaatttggttaagtgatgaatttgggttaccgtctcatgtgaacctggagattcaccagt       c.*1200

          .         .         .         .         .         .       g.20874
 cttaacttttgggtcattgtgttttctctacattcatgcattggatgttttgctaaataa       c.*1260

          .         .         .         .         .         .       g.20934
 ctcctgtggatttaggaatgtgtgctaatagcaatcttcctaattttcatgtttatatgg       c.*1320

          .         .         .         .         .         .       g.20994
 aactatgcagttgagtattgaaagctttaaactgagtttatttacaaggactgagtctag       c.*1380

          .         .         .         .         .         .       g.21054
 cctacagagaacatacagcagccttctttggaccacagtcttatccgaggggtctgtggt       c.*1440

          .         .         .         .         .         .       g.21114
 tgtatcagaagagccactaaaccaatccccctttccaaaattgaacctcacagacgttcc       c.*1500

          .         .         .         .         .         .       g.21174
 tgttttttgtgattgagaaactggtcaatgaacaggaagacttagagatgtttcacaagc       c.*1560

          .         .         .         .                           g.21220
 ctttgatttttgtttcatttatttgtaataaacctcttccacgtga                     c.*1606

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Chaperonin containing TCP1, subunit 5 (epsilon) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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